Medical simulation system, computer system and computer program product

Abstract

A medical simulation system has a replacing section for replacing at least a part of a plurality of biological function state values represented by the biological model and a simulating section for generating post-replacement simulated biological response on the basis of the biological model which reflects the replaced value.

Description

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 is a system construction view of a medical simulation system;

FIG. 2 is a block diagram showing a hardware construction of a server;

FIG. 3 is a block diagram showing overall construction of a biological model;

FIG. 4 is a block diagram showing a construction of pancreas model of the biological model;

FIG. 5 is a block diagram showing a construction of a hepatic model of the biological model;

FIG. 6 is a block diagram showing a construction of insulin kinetics model of the biological model;

FIG. 7 is a block diagram showing a construction of a peripheral tissue model of the biological model;

FIG. 8 is a flow chart showing system overall processing;

FIG. 9 is a schematic view showing an example of a displayed image of measured OGTT time-series data;

FIG. 10 is a flow chart showing parameter set acquisition processing of the biological model;

FIG. 11 is a view showing a template database;

FIG. 12( a) is a graph showing template data of blood glucose level;

FIG. 12( b) is a graph showing template data of insulin concentration;

FIG. 13 is a schematic view showing an example of a displayed image of input OGTT data and pre-replacement simulated biological response;

FIG. 14 is a schematic view showing an example of a displayed image of a pre-replacement parameter set;

FIG. 15 is a schematic view showing an example of a displayed image of biological response before and after replacement in the case where BETA replacement is carried out;

FIG. 16 is a schematic view showing an example of a displayed image of biological response before and after replacement in the case where Kp replacement is carried out;

FIG. 17 is a schematic view showing an example of a circle graph of a cause occupation ratio;

FIG. 18 is a schematic view showing another example of a displayed image of measured OGTT time-series data;

FIG. 19 is a schematic view showing another example of a displayed image of input OGTT data and pre-replacement simulated biological response;

FIG. 20 is a schematic view showing another example of a displayed image of the pre-replacement parameter set;

FIG. 21 is a schematic view showing another example of a displayed image of biological response before and after replacement in the case where BETA replacement is carried out;

FIG. 22 is a schematic view showing another example of a displayed image of biological response before and after replacement in the case where Kp replacement is carried out;

FIG. 23 is a schematic view showing another example of a circle graph of a cause occupation ratio;

FIG. 24 is a block diagram showing structure of a liver model of a biological model in accordance with a second embodiment;

FIG. 25 is a block diagram showing structure of a peripheral tissue model of a biological model in accordance with the second embodiment;

FIG. 26 is a flow chart showing processing procedure of simulated glucose clamp in accordance with the second embodiment;

FIG. 27 is a flow chart showing parameter set generation processing procedure;

FIG. 28( a) is a graph showing measured OGTT time-series data of blood glucose level;

FIG. 28( b) is a graph showing measured OGTT time-series data of blood insulin concentration;

FIG. 29 is a configuration view of the template database;

FIG. 30( a) is a graph showing template data of the blood glucose level;

FIG. 30( b) is a graph showing template data of the insulin concentration;

FIG. 31( a) is a graph showing error summation of blood glucose level of time-series data to a template T1;

FIG. 31( b) is a graph showing error summation of insulin concentration of time-series data to the template T1;

FIG. 32 is a graph showing simulated glucose clamp processing results (change in blood glucose level) for each GIR;

FIG. 33 is a graph showing simulated glucose clamp processing results (change in blood glucose level) in a GIR estimated value;

FIG. 34 is a graph showing simulated glucose clamp processing results (change in insulin) in a GIR estimated value;

FIG. 35 is an explanation view of glucose clamp;

FIG. 36( a) is a graph showing OGTT simulation results of change in blood glucose level of a test subject A;

FIG. 36( b) is a graph showing OGTT simulation results of change in insulin value of the test subject A;

FIG. 37( a) is a graph showing simulated glucose clamp results of change in blood glucose level of the test subject A;

FIG. 37( b) is a graph showing simulated glucose clamp results of change in insulin value of the test subject A;

FIG. 38( a) is a graph showing OGTT simulation results of change in blood glucose level of a test subject B;

FIG. 38( b) is a graph showing OGTT simulation results of change in insulin value of the test subject B;

FIG. 39( a) is a graph showing simulated glucose clamp results of change in blood glucose level of the test subject B;

FIG. 39( b) is a graph showing simulated glucose clamp results of change in insulin value of the test subject B;

FIG. 40( a) is a graph showing OGTT simulation results of change in blood glucose level of a test subject C;

FIG. 40( b) is a graph showing OGTT simulation results of change in insulin value of the test subject C;

FIG. 41( a) is a graph showing simulated glucose clamp results of change in blood glucose level of the test subject C;

FIG. 41( b) is a graph showing simulated glucose clamp results of change in insulin value of the test subject C.

Claims

1. A medical simulation system comprising: biological response input means for receiving input of biological response information representing biological response;biological model generating means for generating a biological model which simulates biological functions by generating a plurality of biological function state values for generating simulated response which simulates the biological response;replacing means for replacing at least a part of a plurality of the biological function state values shown by the biological model; andsimulating means for generating post-replacement simulated biological response on the basis of the biological model which reflects the replaced value.

2. The medical simulation system according to claim 1, further comprising: display means for displaying the post-replacement simulated biological response.

3. The medical simulation system according to claim 1, wherein the replacing means is configured to replace the biological function state values to be replaced with values which a normal living body ought to have.

4. The medical simulation system according to claim 1, further comprising: biological function state value display means for displaying a plurality of the biological function state values.

5. The medical simulation system according to claim 1, further comprising: selecting means for selecting a value to be replaced from a plurality of the biological function state values.

6. The medical simulation system according to claim 2, wherein the display means is configured to display pre-replacement biological response and the post-replacement simulated biological response, wherein the pre-replacement biological response corresponds to the biological function state values which is not replaced.

7. The medical simulation system according to claim 6, wherein the display means is configured to display input biological response or simulated biological response as the pre-replacement biological response, wherein the input biological response is received by the biological response input means and the simulated biological response is generated by the biological model which corresponds to the biological function state values being not replaced.

8. The medical simulation system according to claim 2, wherein the display means is configured to display biological response by a graph showing time course of the biological response.

9. The medical simulation system according to claim 1, wherein the biological model is formed of a mathematical model including a plurality of parameters about biological functions, and the biological function state values are the parameters or values prepared by using the parameters.

10. The medical simulation system according to claim 1, further comprising: judgment support information preparing means for generating judgment support information on the basis of the post-replacement simulated biological response, the judgment support information being used for supporting judgment of therapeutic effects.

11. The medical simulation system according to claim 10, wherein the judgment support information preparing means is configured to generate the judgment support information on the basis of a plurality of the post-replacement simulated biological responses generated by the simulating means using a plurality of the biological models with different ways of replacing the biological function state values.

12. The medical simulation system according to claim 10, further comprising: judgment support information display means for displaying the judgment support information.

13. The medical simulation system according to claim 12, wherein the judgment support information display means is configured to display a graph showing therapeutic effects.

14. A computer program product comprising: a computer readable medium, andsoftware instructions, on the computer readable medium, for enabling the computer to perform predetermined operations comprising:receiving input of biological response information representing biological response;generating a biological model which simulates biological functions by generating a plurality of biological function state values for generating simulated response which simulates the biological response;replacing at least a part of a plurality of the biological function state values shown by the biological model; andgenerating post-replacement simulated biological response on the basis of the biological model which reflects the replaced value.

15. A computer system adapted to perform a simulated test of a living body comprising: a processor, anda memory, under control of the processor, including software instructions adapted to enable the computer system to perform operations comprising:receiving input of results of a first test to a living body;generating a biological model for performing a second test which is different from the first test on the basis of the input results of the first test; andperforming computer simulation of the second test using the biological model.

16. The computer system according to claim 15, wherein the generating step generates a biological model capable of generating the simulated test results which simulate the input first test results.

17. The computer system according to claim 16, wherein the memory further includes software instructions adapted to enable the computer system further to: apply correction for performing the second test to the biological model capable of generating the simulated test results which simulate the input first test results.

18. The computer system according to claim 15, wherein the biological model is configured to generate simulated response which simulates biological response in an actual second test when simulated input corresponding to input given to the living body in the actual second test is given, andthe performing step gives the simulated input to the generated biological model and performs the computer simulation of the second test.

19. The computer system according to claim 15, wherein the first test and the second test are tests on a common disease which are different from each other.

20. The computer system according to claim 19, wherein the disease is diabetes.

21. The computer system according to claim 20, wherein the first test is an oral glucose tolerance test (OGTT).

22. The computer system according to claim 20, wherein the second test is glucose clamp.

23. The computer system according to claim 15, wherein the biological model is configured to output change in blood glucose level of the living body when an insulin infusion rate and a glucose infusion rate input thereto, andthe performing step finds a glucose infusion rate at which the blood glucose level substantially becomes a target value when a predetermined insulin infusion rate is input to the biological model.

24. The computer system according to claim 23, wherein the memory further includes software instructions adapted to enable the computer system further to: determine insulin resistance from the glucose infusion rate obtained by the performing step.

25. A computer program product for enabling a computer to perform a simulated test of a living body comprising: a computer readable medium, andsoftware instructions, on the computer readable medium, for enabling the computer to perform predetermined operations comprising:receiving input of results of a first test to a living body;generating a biological model for performing a second test which is different from the first test on the basis of the input results of the first test; andperforming computer simulation of the second test using the biological model.