Medicament carriers in the form of film having active substance incorporated therein

BACKGROUND OF THE INVENTION
This invention relates to pharmaceutical compositions in unit dosage form comprising a pharmaceutically active medicament compound and a flexible, water-soluble film carrier therefor adapted for enteral or topical administration.
Belgian Pat. No. 637,363 describes paper films coated with pharmaceutically active medicinal compounds suitable for oral administration. The films comprise water-insoluble cellulose fibers and a water-soluble binding agent, preferably sodium carboxymethyl cellulose. In the Examples thereof, the pharmaceutically active compound is applied to the paper film by dripping a solution thereof onto the film, depositing the solid active compound on the surface thereof or by drawing the film through a solution of the active medicament. Using the film drawing machines prescribed in this patent, non-uniform layers of film are formed which shrink upon drying. In the alternative techniques described, the discontinuous process of separately making the film and applying the active medicament thereon has inherent disadvantages which prevent high accuracy in the dosages applied. This is of particular importance with the small doses of medicaments often employed in current pharmacy. Inaccuracies inherently arise not only in applying the active medicament, but also in the manufacture and pre-treatment of the carrier and in variations encountered during subsequent storage of the impregnated carrier material. As a non-uniform material is used as the carrier, the subsequent take-up of active medicament is also inherently non-uniform. Moreover, active medicaments bound only on the surface of the films can readily be removed therefrom during subsequent handling, e.g., in packaging. Furthermore, the carboxymethyl cellulose binding agent becomes detached in the stomach, liberating carboxymethyl cellulose from the carrier which entraps some of the active medicament and liberates it only very slowly, if at all.
OBJECTS OF THE INVENTION
Accordingly, it is a principal object of the present invention to provide improved medicament carriers in the form of a film having a pharmaceutically active compound uniformly incorporated therein.
Another object of the present invention is to provide such carriers which exhibit improved stability during subsequent handling.
A further object of the present invention is to provide such films having multiple pharmaceutical compositions uniformly incorporated therein, whereby incompatible substances can be stored on adjacent areas of the film without adversely interacting with each other.
An additional object of the present invention is to provide a method for the preparation of pharmaceutical compositions in unit dosage form employing a film or sheet carrier, which are adapted for enteral or topical administration.
Upon further study of the specification and appended claims, further objects and advantages of this invention will become apparent to those skilled in the art.
SUMMARY OF THE INVENTION
Briefly, the above and other objects are attained in one aspect of the present invention by providing a process for the manufacture of a pharmaceutical composition in unit dosage form adapted for enteral or topical administration and comprising a safe and effective amount of a pharmaceutically active medicament compound and a flexible, water-soluble film carrier therefor. In accordance with the present invention, the medicament is dissolved or uniformly suspended in a film-forming composition to form a homogeneous solution or dispersion which is then drawn with a film-drawing machine into a sheet, dried and then cut into any desired number and size of unit dosage forms.

DETAILED DISCUSSION
It has now been found that carrier films having a constant thickness and a uniformly homogeneous distribution of active medicament compounds can be obtained by preparing films having the active medicament incorporated therein and using film-forming compounds which are soluble in water and/or polar, water-miscible organic solvents.
In principle, all pharmaceutically active medicaments used in human and veterinary medicine can be employed in accordance with the principles of the present invention. The dosages of active medicament employed are those conventionally used in the art for the particular medicament selected. For internal use, unit dosage forms adapted for oral administration are preferred. For external use, unit dosage forms adapted for either enteral or topical administration can be employed, e.g., for topical administration on the skin and in body cavities such as the nose, ears, rectum, vagina, etc.
Suitable pharmaceutically active medicament compounds which can be employed in accordance with the present invention include but are not limited to hormones, e.g., cyproterone acetate, progesterone, estradiol, testosterone, insulin, triiodthyronin, cortisone, etc.;
prostaglandins, e.g., prostaglandin E.sub.1, prostaglandin E.sub.2, prostaglandin A.sub.1 and prostaglandin F.sub.2.alpha. ;
vitamins, e.g., vitamin A, vitamin D.sub.2, vitamin D.sub.3, vitamin E, vitamin K.sub.1, vitamin K.sub.2 and derivatives of vitamin B.sub.1, e.g., thiamine tetrahydrofurfuryl disulfide or thiamine propyldisulfide;
antibiotics, e.g., erythromycin and tetracycline;
contraceptives, e.g., chlormadinone, chlormadinone acetate, megestrol acetate, d-norgestrel, medroxyprogesterone acetate, norethisterone, norethisterone acetate, etc.;
and spermicides, e.g., p-diisobutylphenoxypolyethoxyethanol.
The drugs are employed in at least the pharmaceutically active amounts known in the art.
Of these, especially preferred medicinally active substances are the gestagens, estrogens and mixtures thereof, tranquilizers, anti-diabetics, sulfonamides, antibiotics, trichomonal agents, anti-inflammatory agents such as corticoids, etc.
Suitable films having a constant thickness and a uniform distribution of the medicinally active ingredients therein can be obtained by preparing films having the active medicament incorporated therein using film-forming polymers which are soluble in water or polar organic solvents, preferably film-forming polymers which are soluble both in water and in polar water-miscible organic solvents. Suitable such film-forming polymers are known in the art and include but are not limited to poly-N-vinyl-pyrrolidone, copolymers of vinyl-pyrrolidone and vinyl acetate, methyl-cellulose, ethyl-cellulose, etc.; preferably non-ionic, water-soluble, hydroxyalkyl ethers of cellulose and especially hydroxypropyl-cellulose, hydroxyethyl-cellulose and methylhydroxypropyl-cellulose.
As the films are formed by drawing in accordance with the present invention rather than by casting or by other known film-forming techniques, a release agent or parting compound is included in the composition to be drawn. Suitable release agents are likewise known in the art and include but are not limited to polyoxyethylene-polyoxypropylene copolymers, especially Pluronic F 68, polyoxyl stearates, alkyl- or alkanoyl-substituted polyaddition products of ethylene oxides, e.g., Cremophor EL, silicones and silicone parting emulsions, glycerine, propylene glycol, metal soaps, etc.
Suitable pharmaceutically acceptable fillers can also be employed if desired; such fillers are likewise known in the art and include but are not limited to cellulose; sugars, e.g., lactose, dextrose, cane sugar, etc.; starches; polyhydric alcohols, e.g., mannitol; inorganic fillers such as calcium carbonate, calcium phosphate, talc, etc.; and dyestuffs, either in soluble form or as pigments. The fillers are optional, and may be partially or wholly replaced by one or more pharmaceutically active substances. When using soluble fillers or pharmaceutically active substances, a transparent, smooth film is formed, while the use of insoluble fillers or active medicaments results in the formation of a white or colored, paper-like film.
The medicaments may be present in the carrier material either in a dissolved or uniformly suspended state. The proportion of pharmaceutically active ingredients in the film may be from a pharmaceutically effective trace amount up to about 60% by weight without deleteriously affecting the physical properties thereof. The drawn film surfaces can be cut or perforated to form simple single unit dosages which contain the customary active medicaments which have previously been used in the form of tablets, dragees, salves, suppositories, etc. Thus, the quantity of active medicament per single unit dose may be as high as desired depending on the mode of use, typically from about one microgram to 0.5 grams, but the lower and upper dosages may easily be reduced or increased. Of course, it is also possible to simultaneously form placebo carriers which otherwise correspond in composition to the unit dosage form of the present invention but are free of the medicament ingredient therein.
In preparing the unit dosage forms of the present invention, the medicament and a release agent (which may be omitted if the medicament employed itself has parting compound properties) are first dissolved or suspended in water and/or one or more polar organic solvents, preferably an admixture of water and a polar organic solvent which is miscible therewith or two organic solvents. The only criticality with respect to the choice of organic solvent is that it be relatively volatile so that only physiologically tolerable residues thereof are removed during the drawing step. Suitable such solvents are known in the art and include but are not limited to ethanol, isopropanol, acetone, methylene chloride, mixtures thereof, etc. Preferably, water, ethanol or mixtures thereof or mixtures of ethanol and methylene chloride are employed.
Into the solution or suspension of medicament and suspension medium is introduced about 6-20% by weight of the film-forming polymer, up to 30% by weight of a suitable filler, and preferably about 0.01-2% by weight of a release agent. The resultant admixture is rendered homogeneous by stirring or other suitable techniques, and the homogeneous solution or suspension is then drawn out on a film-drawing machine into a tissue-like sheet and dried. The film obtained upon drying the sheet is then divided into unit dosage sections. The layer thickness of the wet sheet is generally about 0.1-2 mm, while the layer thickness of the dry film is about 0.05-1 mm, preferably 0.07-0.3 mm.
The process of making the unit dosage forms of the present invention into a film in a single operation can be conducted continuously, and has the advantage that the medicament is homogeneously and uniformly distributed throughout the medicament carrier. By merely varying the concentration of the active medicament in the carrier, the thickness of the film and the area of the film employed per unit dosage, the amount of medicament per unit dose can be varied in an elegantly simple fashion.
A particular advantage of the present invention lies in the ability with which films can be prepared from a single sheet in which different pharmaceutically active medicaments and/or varying concentrations of active ingredients are incorporated side by side across the width of a drawn web. By using a doctor having two or more compartments during the drawing operation, different solutions or suspensions can be simultaneously drawn out into a coherent sheet without mixing the different ingredients. The width and thickness of the sheet can be adjusted separately for each compartment, providing a further measure of flexibility in the process of the present invention. If desired, the zones or strips having different active substances or different concentrations thereof can be visually identified by the use of different dyestuffs in each compartment. Upon drawing the wet sheet, a film is obtained which, by being suitably divided such as by simple perforation, can provide unit dosages containing different medicaments and/or different concentrations thereof, as well as placebos containing no medicament. Such films containing different medicaments and/or different concentrations thereof are widely used in modern pharmacology for making multi-phase preparations, such as contraceptive preparations. By providing a spatial separation of different medicaments which are storage-incompatible with each other on a single film unit, the shelf stability of each individual ingredient is greatly enhanced. Other applications will be readily apparent to those skilled in the art to which the invention pertains; for example, films for intravaginal application can simply be rolled about an ordinary commercial tampon for administration.
Without further elaboration, it is believed that one skilled in the art can, using the preceding description, utilize the present invention to its fullest extent. The following preferred specific embodiments are, therefore, to be construed as merely illustrative and not limitative of the remainder of the disclosure in any way whatsoever. In the following Examples, the temperatures are set forth uncorrected in degrees Celsius; unless otherwise indicated, all parts and percentages are by weight.
Pharmaceutical grade reagents as defined in the current DAB (Deutsches Arzneibuch) Pharmacopoeia were employed in the following Examples. With the exception of Examples 5 and 16, the preparations described by way of example are preponderantly suitable for oral administration.
EXAMPLE 1
Preparation for 1000 units
0.25 gram of d-norgestrel,
0.05 gram of ethinyl-estradiol and
0.84 gram of polyoxyethylene-polyoxypropylene copolymer are dissolved in
95.00 grams of ethyl alcohol with stirring, and into the resultant solution is homogeneously introduced a powdered mixture of
16.93 grams of hydroxypropyl-cellulose and
16.93 grams of cellulose
The resultant suspension is drawn on a suitable film drawing apparatus to a sheet having a thickness of 500 .mu.m, and is then dried.
The composition of one unit:
______________________________________ 0.25 mg. of d-norgestrel 0.05 mg. of ethinyl-estradiol 0.84 mg. of polyoxyethylene-polyoxypropylene copolymer16.93 mg. of hydroxypropyl-cellulose16.93 mg. of cellulose35.00 mg.______________________________________
One unit corresponds to an area of about 3 cm.sup.2.
Appearance of the film: white, paper-like.
The dry film has a thickness of about 170 .mu.m.
EXAMPLE 2
A preparation for 1000 units
1.10 grams of Cremophor EL.RTM. are dissolved in
152.00 grams of water. In this solution are homogeneously suspended.
0.25 gram of micronized d-norgestrel and
0.05 gram of micronized ethinyl-estradiol. Into the suspension are introduced
22.10 grams of hydroxypropyl-cellulose and
16.50 grams of cellulose.
The suspension so obtained is drawn on a suitable film drawing apparatus to a sheet having a thickness of 500 .mu.m, and is then dried.
The composition for one unit:
______________________________________ 0.25 mg. of d-norgestrei 0.05 mg. of ethinyl-estradiol 1.10 mg. of Cremophor EL.RTM.22.10 mg. of hydroxypropyl-cellulose16.50 mg. of cellulose40.00 mg.______________________________________
One unit corresponds to an area of about 3 cm.sup.2.
Appearance of the film: white, paper-like.
The dry film has a thickness of about 170 .mu.m.
EXAMPLE 3
A preparation for 1000 units
0.03 gram of d-norgestrel and
0.84 gram of polyoxyl-40-stearate are dissolved, while stirring, in
95.00 grams of ethyl alcohol. Into this solution is introduced a powdered mixture of
16.93 grams of hydroxypropyl-cellulose and
17.20 grams of cellulose.
The suspension so obtained is drawn by a suitable film drawing apparatus onto a sheet having a thickness of 500 .mu.m, and is then dried.
The composition of one unit:
______________________________________ 0.03 mg. of d-norgestrel 0.84 mg. of polyoxyl-40-stearate16.93 mg. of hydroxypropyl-cellulose17.20 mg. of cellulose35.00 mg.______________________________________
One unit corresponds to an area of about 3 cm.sup.2.
Appearance of the film: white, paper-like.
The dry film has a thickness of about 170 .mu.m.
EXAMPLE 4
A preparation for 1000 units
1.10 grams of polyoxyethylene-polyoxypropylene copolymer are dissolved in
152.00 grams of demineralized water. In this solution is suspended
0.03 gram of micronized d-norgestrel to form a homogeneous suspension. Into the suspension are introduced
22.10 grams of hydroxypropyl-cellulose and
16.77 grams of cellulose.
The suspension so obtained is drawn on a suitable film drawing apparatus to a sheet having a thickness of 500 .mu.m, and is then dried.
The composition for one unit:
______________________________________ 0.03 mg. of d-norgestrel1.10 mg. of polyoxyethylene-polyoxypropylene copolymer22.10 mg. of hydroxypropyl-cellulose16.77 mg. of cellulose40.00 mg.______________________________________
One unit corresponds to an area of about 3 cm.sup.2.
Appearance of the film: white, paper-like.
The dry film has a thickness of about 170 .mu.m.
EXAMPLE 5
A preparation for 1000 units
0.025 gram of fluocortolone trimethylacetate and
0.183 gram of glycerine are dissolved in
30.000 grams of ethyl alcohol. Into this solution are introduced
7.292 grams of hydroxypropyl-cellulose.
The solution so obtained is drawn on a suitable film drawing apparatus to a sheet having a thickness of 500 .mu.m, and is then dried.
The composition of one unit:
______________________________________0.025 mg. of fluocortolone trimethylacetate0.183 mg. of glycerine7.292 mg. of hydroxypropyl-cellulose7.500 mg.______________________________________
One unit corresponds to an area of about 1 cm.sup.2.
Appearance of the film: transparent.
The dry film has a thickness of about 70 .mu.m.
The film is suitable for topical use.
EXAMPLE 6
A preparation for 1000 units
10.00 grams of 7-chloro-2-methylamino-5-phenyl-3H-1,4-benzo-diazepine-4-oxide and
0.84 gram of polyoxyethylene-polyoxypropylene copolymer are dissolved in
95.00 grams of ethyl alcohol. Into this solution is introduced a powdered mixture of
16.93 grams of hydroxypropyl-cellulose and
7.23 grams of cellulose.
The suspension so obtained is drawn on a suitable film drawing apparatus to a sheet having a thickness of 500 .mu.m, and is then dried.
The composition of one unit:
______________________________________10.00 mg. of 7-chloro-2-methylamino-5-phenyl-3H-1,4- benzo-diazepine-4-oxide0.84 mg. of polyoxyethylene-polyoxypropylene copolymer16.93 mg. of hydroxypropyl-cellulose 7.23 mg. of cellulose -35.00 mg.______________________________________
One unit corresponds to an area of about 3 cm.sup.2.
Appearance of the film: yellow, paper-like.
The dry film has a thickness of about 170 .mu.m.
EXAMPLE 7
A preparation for 1000 units
1.00 gram of norethisterone acetate,
0.03 gram of ethinyl-estradiol and
0.84 gram of polyoxyethylene-polyoxypropylene copolymer are dissolved in
95.00 grams of ethyl alcohol. Into this solution is introduced a powdered mixture of
16.93 grams of hydroxypropyl-cellulose and
16.20 grams of cellulose.
The suspension so obtained is drawn on a suitable film drawing apparatus to a sheet having a thickness of 500 .mu.m, and is then dried.
The composition for one unit:
______________________________________1.00 gm. of norethisterone acetate0.03 mg. of ethinyl-estradiol0.84 mg. of polyoxyethylene-polyoxypropylene copolymer16.93 mg. of hydroxypropyl-cellulose16.20 mg. of cellulose35.00 mg.______________________________________
One unit corresponds to an area of about 3 cm.sup.2.
Appearance of the film: white, paper-like.
The dry film has a thickness of about 170 .mu.m.
EXAMPLE 8
A preparation for 1000 units
1.00 gram of noresthisterone acetate,
0.03 gram of ethinyl-estradiol and
0.84 gram of propylene glycol are dissolved in a mixture of
101.60 grams of methylene chloride and
26.40 grams of ethyl alcohol. Into this solution is introduced a powdered mixture of
8.47 grams of hydroxypropyl-cellulose,
8.47 grams of hydroxyethyl-cellulose and
16.19 grams of cellulose.
The suspension so obtained is drawn on a suitable film drawing apparatus to a sheet having a thickness of 500 .mu.m, and is then dried.
The composition for one unit:
______________________________________1.00 mg. of noresthisterone acetate0.03 mg. of ethinyl-estradiol0.84 mg. of propylene glycol8.47 mg. of hydroxypropyl-cellulose8,47 mg. of hydroxyethyl-cellulose16.19 mg. of cellulose35.00 mg.______________________________________
One unit corresponds to an area of about 3 cm.sup.2.
Appearance of the film: white, paper-like.
The dry film has a thickness of about 170 .mu.m.
EXAMPLE 9
A preparation for 1000 units
1.00 gram of noresthisterone acetate,
0.03 gram of ethinyl-estradiol and
0.84 gram of polyoxyethylene-polyoxypropylene copolymer are dissolved in
101.60 grams of methylene chloride and
25.40 grams of ethyl alcohol. Into this solution is introduced a powdered mixture of
16.93 grams of hydroxyethyl-cellulose and
16.20 grams of starch.
The suspension so obtained is drawn on a suitable film drawing apparatus to a sheet having a thickness of 500 .mu.m, and is then dried.
The composition for one unit:
______________________________________1.00 mg. of norethisterone acetate0.03 mg. of ethinyl-estradiol0.84 mg. of polyoxyethylene-polyoxypropylene copolymer16.93 mg. of hydroxyethyl-cellulose and16.20 mg. of starch35.00 mg.______________________________________
One unit corresponds to an area of about 3 cm.sup.2.
Appearance of the film: white, paper-like.
The dry film has a thickness of about 170 .mu.m.
EXAMPLE 10
A preparation for 1000 units
1.00 gram of norethisterone acetate,
0.03 gram of ethinyl-estradiol and
0.84 gram of polyoxyl-40-stearate are dissolved in
95.00 grams of ethyl alcohol. Into this solution is introduced a powdered mixture of
16.93 grams of hydroxypropyl-cellulose,
8.10 grams of lactose and
8.10 grams of maize starch.
The suspension so obtained is drawn on a suitable film drawing apparatus to a sheet having a thickness of 500 .mu.m, and is then dried.
The composition for one unit:
______________________________________1.00 mg. of noresthisterone acetate0.03 mg. of ethinyl-estradiol0.84 mg. of polyoxyl-40-stearate16.93 mg. of hydroxypropyl-cellulose8.10 mg. of lactose8.10 mg. of maize starch35.00 mg.______________________________________
One unit corresponds to an area of about 3 cm.sup.2.
Appearance of the film: white, paper-like.
The dry film has a thickness of about 170 .mu.m.
EXAMPLE 11
A preparation for 1000 units
1.00 gram of norethisterone (17.alpha.-ethinyl-19-nor-testosterone
0.03 gram of ethinyl-estradiol and
0.22 gram of polyoxyethylene-polyoxypropylene copolymer are dissolved in a mixture of
84.75 grams of ethyl alcohol and
4.00 grams of water. Into this solution is introduced a powdered mixture of
6.00 grams of hydroxypropyl-cellulose and
16.00 grams of cellulose.
The suspension so obtained is drawn on a suitable film drawing apparatus to a sheet having a thickness of 600 .mu.m, and then dried.
The composition for one unit:
______________________________________1.00 mg. of norethisterone (17.alpha.-ethinyl-19- nor-testosterone)0.03 mg. of ethinyl-estradiol0.22 mg. of polyoxyethylene-polyoxypropylene copolymer16.00 mg. of hydroxypropyl-cellulose16.00 mg. of cellulose33.25 mg.______________________________________
One unit corresponds to an area of about 3 cm.sup.2.
Appearance of the film: white, paper-like.
The dry film has a thickness of approximately 230 .mu.m.
EXAMPLE 12
A preparation for 1000 units
4.0 grams of glisoxepide* in micronized form are suspended in
0.9 gram of polyoxyl-40-stearate dissolved in
152.0 grams of water to form a homogeneous suspension. Into the suspension are introduced
15.0 grams of hydroxyethyl-cellulose and
15.1 grams of calcium carbonate.
*Glisoxepide is 4-{4-[.beta.-(5-methyl-isoxazol-3-carboxamido)ethyl]-benzolsulfonyl}-1,1-hexamethylene-semicarbazide.
The suspension so obtained is drawn on a suitable film drawing apparatus to a sheet having a thickness of 500 .mu.m and dried.
The composition for one unit:
______________________________________4.00 mg. of glisoxepide*0.90 mg. of polyoxyl-40-stearate15.00 mg. of hydroxyethyl-cellulose15.10 mg. of calcium carbonate35.00 mg.______________________________________
One unit corresponds to an area of about 3 cm.sup.2.
Appearance of the film: white, paper-like.
The dry film has a thickness of about 170 .mu.m.
EXAMPLE 13
A preparation for 1000 units
0.030 gram of d-norgestrel is dissolved in
40.000 grams of methylene chloride and
55.000 grams of ethanol. Into this solution are introduced
0.840 gram of silicone oil
6.930 grams of methyl-cellulose and
10.000 grams of poly-N-vinyl-pyrrolidone and
17.200 grams of starch to form a homogeneous suspension.
The suspension so obtained is drawn on a suitable film drawing apparatus to a sheet having a thickness of 500 .mu.m and dried.
The composition of one unit:
______________________________________0.030 mg. of d-norgestrel0.840 mg. of silicone oil6.930 mg. of methyl-cellulose10.000 mg. of poly-N-vinyl-pyrrolidone17.200 mg. of starch35.000 mg.______________________________________
One unit corresponds to an area of about 3 cm.sup.2.
Appearance of the film: white, paper-like.
The dry film has a thickness of about 170 .mu.m.
EXAMPLE 14
A preparation for 1000 units
0.84 gram of polyoxyethylene-polyoxypropylene copolymer is dissolved in
95.00 grams of ethyl alcohol while stirring, and into this solution is introduced a powdered mixture of
17.08 grams of hydroxypropyl-cellulose and
17.08 grams of cellulose.
The suspension so obtained is drawn on a suitable film drawing apparatus to a sheet having a thickness of 500 .mu.m, and then dried.
The composition for one unit:
______________________________________0.84 mg. of polyoxyethylene-polyoxypropylene copolymer17.08 mg. of hydroxypropyl-cellulose17.08 mg. of cellulose35.00 mg.______________________________________
EXAMPLE 15
A preparation for 1000 units
0.04 gram of saccharin,
0.04 gram of cream essence and
0.40 gram of polyoxyethylene-polyoxypropylene copolymer are dissolved in a mixture of
79.00 grams of ethyl alcohol and
4.00 grams of water. Into this solution are introduced
30.00 grams of iron(II) fumarate,
15.00 grams of hydroxypropyl-cellulose,
5.52 grams of cocoa and
4.00 grams of cellulose to form a homogeneous mixture. The suspension so obtained is drawn on a suitable film drawing apparatus to a sheet having a thickness of 0.5 mm, and then dried.
The composition for one unit:
______________________________________30.00 mg. of iron(II) fumarate15.00 mg. of hydroxypropyl-cellulose4.00 mg. of cellulose0.40 mg. of polyoxyethylene-polyoxypropylene copolymer5.52 mg. of cocoa0.04 mg. of saccharin0.04 mg. of cream essence55.00 mg. Weight per unit______________________________________
One unit corresponds to an area of about 3 cm.sup.2.
Appearance of the film: pale red-brown.
EXAMPLE 16
Films for intravaginal application: The film is prepared in accordance with Example 11.
The composition of one unit:
______________________________________100.0 mg. of 5-morpholinomethyl-3-(5-nitro-1-methyl-2- imidazolyl)-methyleneamino-2-oxazolidinone.HCl8.4 mg. of Cremophor EL.RTM.169.2 mg. of methylhydroxypropyl-cellulose72.4 mg. of cellulose350.0 mg. Weight of one unit.______________________________________
One unit corresponds to an area of about 8 .times. 4 cm.
Appearance of the film: pale yellow.
The film (1 unit) is either rolled around an ordinary commercial tampon or is itself rolled to form a narrow tube.
EXAMPLE 17
This Example demonstrates the simplicity of a two-phase preparation in accordance with the present invention.
______________________________________Part A: 21 units containing active substance.Part B: 7 units without active substance (placebo). Preparation for 3000 units, Part A. 0.75 gram of d-norgestrel, 0.15 gram of ethinyl-estradiol and 0.54 gram of polyoxyethylene-polyoxypropylene copolymer are dissolved in a mixture of 237.00 grams of ethyl alcohol and 12.00 grams of water. Into this solution are introduced 44.28 grams of hydroxypropyl-cellulose and 44.28 grams of cellulose to form a homogeneous suspension. Preparation for 1000 units, Part B. 0.18 gram of polyoxyethylene-polyoxypropylene copolymer is dissolved in a mixture of 79.00 grams of ethyl alcohol and 4.00 grams of water. Into this solution are introduced 14.91 grams of hydroxypropyl-cellulose and 14.91 grams of cellulose to form a homogeneous suspension______________________________________
The suspensions so obtained are drawn on a suitable film drawing apparatus having a two compartment doctor (widths of the compartments: #1 = 54 mm; #2 = 18 mm) to form a sheet of 0.5 mm and then dried. By appropriate division into units measuring 18 .times. 18 mm, e.g., by perforation, the film can be divided over its width into three units containing active substance and one placebo unit free of active substance. There may be produced in the web of film any desired number of sections having a ratio of three units containing active substance to one placebo unit containing no active substance.
The composition of each unit:
______________________________________Part A (containing active substance). Part B (placebo).______________________________________0.25 mg. of d-norgestrel --0.05 mg. of ethinyl-estradiol --14.76 mg. of hydroxypropyl-cellulose 14.91 mg.14.76 mg. of cellulose 14.91 mg.0.18 mg. of polyoxyethylene-polyoxy- 0.18 mg.30.00 mg. propylene copolymer 30.00 mg. Area per unit: about 3 cm.sup.2. Appearance: white.______________________________________
EXAMPLE 18
This Example demonstrates the ease of making a three-phase preparation containing two active substance phases and a placebo in accordance with the present invention.
______________________________________Part A: 11 units containing 0.05 mg. of d-norgestrel 0.05 mg. of ethinyl-estradiol.Part B: 10 units containing 0.125 mg. of d-norgestrel 0.050 mg. of ethinyl-estradiol.Part C: 7 placebo units without active substance. Preparation for 1100 units, Part A. 0.055 gram of d-norgestrel, 0.055 gram of ethinyl-estradiol and 0.198 gram of polyoxyethylene-polyoxypropylene copolymer are dissolved in mixture of 86.900 grams of ethyl alcohol and 4.400 grams of water. Into this solution are introduced 16.346 grams of hydroxypropyl-cellulose and 16.346 grams of cellulose to form a homogeneous suspension. Preparation for 1000 units, Part B. 0.125 gram of d-norgestrel, 0.050 gram of ethinyl-estradiol and 0.180 gram of polyoxyethylene-polyoxypropylene copolymer are dissolved in a mixture of 79.000 grams of ethyl alcohol and 4.000 grams of water. Into this solution are introduced 14.823 grams of hydroxypropyl-cellulose and 14.823 grams of cellulose to form a homogeneous suspension. Preparation for 700 units, Part C. 0.189 gram of polyoxyethylene-polyoxypropylene copolymer is dissolved in a mixture of 82.950 grams of ethyl alcohol and 4.200 grams of water. Into this solution are introduced 15.656 grams of hydroxypropyl-cellulose and 15.655 grams of cellulose to form a homogeneous suspension.______________________________________
The suspensions so obtained are drawn on a suitable film drawing apparatus having a three compartment doctor (width per compartment 18 mm) into a sheet and dried. By appropriate division, e.g., by perforation, there can be distributed over the width of the film three units of 18 .times. 18 mm for Part A, of 18 .times. 19.8 mm for Part B and of 18 .times. 28 mm for Part C, each having different contents of active substance. There can be separated from the film web preparations having 11 units of Part A, 10 units of Part B and 7 units of Part C.
The composition per unit:
______________________________________Part A Part B Part C Ingredients______________________________________ 0.050 mg. 0.125 mg. -- d-norgestrel 0.050 mg. 0.050 mg. -- ethinyl-estradiol polyoxyethylene- 0.180 mg. 0.180 mg. 0.270 mg. polyoxypropylene copolymer14.860 mg. 14.823 mg. 22.366 mg. hydroxypropyl-cellulose14.860 mg. 14.822 mg. 22.364 mg. cellulose30.000 mg. 30.000 mg. 45.000 mg. weight per unitabout about about3 cm.sup.2 3.5 cm.sup.2 5 cm.sup.2 area per unitwhite white white appearance______________________________________
EXAMPLE 19
The various phases need not contain the same pharmaceutically active ingredients, as is shown by the following three-phase preparation.
______________________________________Part A: 11 units containing 0.05 mg. of d-norgestrel 0.05 mg. of ethinyl-estradiolPart B: 10 units containing 0.125 mg. of d-norgestrel 0.050 mg. of ethinyl-estradiolPart C: 7 units containing 50.00 mg. of iron(II) fumarate. Preparation for 1100 units, Part A. 0.066 gram of food color yellow No. 2 (tartrazine; E 102) is dissolved in 4.400 grams of water, and then introduced into 86.900 grams of ethyl alcohol. In this solution are dissolved 0.055 gram of d-norgestrel, 0.055 gram of ethinyl-estradiol and 0.198 gram of polyoxyethylene-polyoxypropylene copolymer. Into this solution are introduced 16.313 grams of hydroxypropyl-cellulose and 16.313 gram of cellulose to form a homogeneous suspension. Preparation for 1000 units, part B. 0.065 gram of food color orange No. 2 (sunset Yellow; E 110) is dissolved in 4.000 grams of water, and then introduced into 79.000 grams of ethyl alcohol. In this solution are dissolved 0.125 gram of d-norgestrel, 0.050 gram of ethinyl-estradiol and 0.180 gram of polyoxyethylene-polyoxypropylene copolymer. Into this solution are introduced 14.790 grams of hydroxypropyl-cellulose and 14.790 grams of cellulose to form a homogeneous suspension. Preparation for 700 units, Part C. 0.042 gram of saccharin, 0.042 gram of cream essence and 0.406 gram of polyoxyethylene-polyoxypropylene copolymer are dissolved in a mixture of 55.300 grams of ethyl alcohol and 2.800 grams of water. Into this solution are introduced 35.000 grams of iron(II) fumarate, 17.500 grams of hydroxypropyl-cellulose, 5.950 grams of cocoa and 4.060 gram of cellulose to form a homogeneous suspension.______________________________________
The suspensions so prepared are drawn on a suitable film drawing apparatus having a three compartment doctor (width per compartment 18 mm) into a sheet and dried. By appropriate division, e.g., by perforation, there can be distributed over the width of the film three units of 18 .times. 18 mm for Part A, of 18 .times. 19.8 mm for Part B and of 18 .times. 28 mm for Part C, each having different contents of active substance. There can be separated from the film web preparations having 11 units of Part A, 10 units of Part B and 7 units of Part C.
The composition per unit:
______________________________________Part A Part B Part C Ingredients______________________________________ 0.050 mg. 0.125 mg. -- d-norgestrol 0.050 mg. 0.050 mg. -- ethinyl-estradiol-- -- 50.000 mg. iron(II) fumarate polyoxethylene- 0.180 mg. 0.180 mg. 0.580 mg. polyoxypropylene copolymer 0.060 mg. -- -- food color Yellow No. 2-- 0.065 mg. -- food color Orange No. 214.830 mg. 14.790 mg. 25.000 mg. hydroxypropyl-cellulose14.830 mg. 5.800 mg. cellulose-- -- 8.500 mg. cocoa-- -- 0.060 mg. saccharin-- -- 0.060 mg. cream essence30.000 mg. 30.000 mg. 90.000 mg. weight per unitabout about about3 cm.sup.2 3.5 cm.sup.2 5 cm.sup.2 area per unityellow orange brown appearance______________________________________
EXAMPLE 20
Preparation for 1000 units
0.15 gram of d-norgestrel,
0.03 gram of ethinyl-estradiol and
0.84 gram of polyoxyethylene-polyoxypropylene copolymer are dissolved in
95.00 grams of ethyl alcohol while stirring and a powdered mixture of
16.99 grams of hydroxypropyl-cellulose and
16.99 grams of cellulose is introduced into this solution.
The suspension obtained is drawn out on a suitable film drawing apparatus to a very thin film having a thickness of 500 .mu.m, and is then dried.
The composition of one unit:
______________________________________0.15 mg. of d-norgestrel0.03 mg. of ethinyl-estradiol0.84 mg. of polyoxyethylene-polyoxypropylene copolymer16.99 mg. of hydroxypropyl-cellulose16.99 mg. of cellulose35.00 mg.______________________________________
One unit corresponds to an area of approximately 3 cm.sup.2.
Appearance of the film: white, paper-like.
The dry film has a thickness of approximately 170 .mu.m.
The preceding examples can be repeated with similar success by substituting the generically or specifically described reactants and/or operating conditions of this invention for those used in the preceding examples.
From the foregoing description, one skilled in the art can easily ascertain the essential characteristics of this invention, and without departing from the spirit and scope thereof, can make various changes and modifications of the invention to adapt it to various usages and conditions.

Number	Date	Country	Kind
2432925	Jul 1974	DEX
2449865	Oct 1974	DEX

Number	Name	Date
982370	Kurt	Jan 1911
1920118	Walsh et al.	Jul 1933
2371075	Spertus	Mar 1945
2562373	Arnold	Jul 1951
2789935	Drummond et al.	Apr 1957
3449469	Gavne	Jun 1969
3517094	Forrest	Jun 1970
3535409	Rohde	Oct 1970
3565737	Lefevre et al.	Feb 1971
3626940	Zaffaroni	Dec 1971
3715420	Kiyono et al.	Feb 1973
3767737	Lundstrom	Oct 1973
3775239	Snow	Nov 1973
3845201	Haddad et al.	Oct 1974
3847585	Chisholm	Nov 1974
3868445	Ryde et al.	Feb 1975
3875300	Homm et al.	Apr 1975
3880991	Yolles	Apr 1975
3892665	Stigdmann et al.	Jul 1975
3988098	Kato et al.	Oct 1976
3991149	Hurwitt	Nov 1976

Number	Date	Country
637363	Sep 1962	BEX
1243454	Aug 1971	GBX

Medicament carriers in the form of film having active substance incorporated therein

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