Claims
- 1. A compound of the formula
- Ar--CO--X--Z
- the stereoisomers and pharmaceutically acceptable salts thereof, wherein Ar represents a radical of the formula: ##STR27## wherein in Group D, one of R.sub.6 or R.sub.7 is C.sub.1-6 alkyl and the other is C.sub.1-6 alkyl, phenyl or phenyl C.sub.1-4 alkyl optionally substituted in either phenyl ring by one or two of C.sub.1-6 alkyl, C.sub.1-6 alkoxy, or halogen, or R.sub.6 and R.sub.7 together are C.sub.2-6 polymethylene or C.sub.2-5 polymethylene interrupted by an --O--linkage, R.sub.2 and R.sub.3 are independently H or halogen;
- wherein in Group E, R.sub.4 is H or C.sub.1-6 alkoxy, R.sub.5 is H or C.sub.1-6 alkoxy, R.sub.2 is H, halogen, CF.sub.3, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, C.sub.1-6 -alkylthio, C.sub.1-6 alkylsulfonyl, C.sub.1-6 alkylsulfinyl, C.sub.1-7 acyl, cyano, C.sub.1-6 alkoxycarbony, C.sub.1-7 acylamino, hydroxy, nitro, amino, aminocarbonyl, or aminosulfonyl, optionally N-substituted by one or two groups selected from C.sub.1-6 alkyl, C.sub.3-8 cycloalkyl, C.sub.3-8 cycloalkyl and C.sub.1-4 alkyl or disubstituted by C.sub.4 or C.sub.5 polymethylene; phenyl or phenyl C.sub.1-4 alkyl group optionally substituted in the phenyl ring by one or two of halogen, C.sub.1-6 alkoxy or C.sub.1-6 alkyl groups, R.sub.2 and R.sub.3 are independently H or halogen;
- X is NH or O; and
- Z represents a radical of the formula ##STR28## wherein q is 1 or 2.
- 2. A compound according to claim 1 wherein Ar is group D.
- 3. A compound according to claim 1 wherein Ar is group E.
- 4. A pharmaceutical composition for the treatment of anxiety, psychoses, depression, gastrointestinal motility disturbances or conditions responsive to 5-HT.sub.3 antagonist effect comprising a therapeutically effective amount of a compound as defined in claim 1 and a pharmaceutically acceptable carrier or diluent.
- 5. A pharmaceutical composition according to claim 4 wherein Ar is group D.
- 6. A pharmaceutical composition according to claim 4 wherein Ar is Group E.
Parent Case Info
This is a division of application Ser. No. 07/666,278, filed Mar. 7, 1991, U.S. Pat. No. 5,137,893.
US Referenced Citations (8)
Foreign Referenced Citations (12)
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Date |
Country |
6712187 |
Jul 1987 |
AUX |
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Non-Patent Literature Citations (1)
Entry |
Fludzinski et al., J. Med. Chem., Inazoles as Indole Bioesters, 30 No. 9, 1535-7, Apr. 19, 1987. |
Divisions (1)
|
Number |
Date |
Country |
Parent |
666278 |
Mar 1991 |
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