Claims
- 1. A methanediphosphonate derivative represented by the formula (I): ##STR44## where, X represents H, a straight chain or branched chain alkyl group having 1 to 8 carbon atoms that is either unsubstituted or substituted, an aryl group, or an acyl group,
- Y represents a halogen atom, nitrile group, nitro group, alkyl group, alkoxy group, trifluoromethyl group, hydroxyl group, acyloxy group, acylamino group, acyl group, alkenyl group, aryl group, cycloalkyl group, COOH group, COO alkyl group, ##STR45## (wherein Z.sup.1 and Z.sup.2 represent, independently of each other, hydrogen atoms or alkyl groups, or Z.sup.1 and Z.sup.2 may form a composed of carbon atoms or a ring composed of carbon atoms containing hetero atoms or ##STR46## (wherein Z.sup.1 and Z.sup.2 represent the same groups as indicated above, and Z.sup.3 represents oxygen or sulfur),
- m represents an integer of 1 to 5, n represents an integer of 0 to 4 (provided that m+n is 5 or less), the m number of XS and the n number of Y may be either identical or different, respectively,
- . . represents a double bond or a single bond,
- A is --(CH.sub.2)a--(D)b--(CH.sub.2)c-- (D is sulfur, oxygen, NH, alkyl-substituted N or CH.sub.2, a and c are integers of 0 to 10, and b is 0 or 1), or --(CH.dbd.CH)d--CH.dbd. (d is an integer of 0 to 2, and B does not exist in the case when A represents --(CH.dbd.CH)d--CH.dbd.,
- B represents a hydrogen atom, an alkyl group, amino group, monoalkylamino group, dialkylamino group, acylamino group, hydroxyl group, an alkoxy group, trialkylsiloxy group or acyloxy group, and
- R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are identical or different, and are hydrogen atoms, straight or branched chain alkyl groups having 1 to 7 carbon atoms or pharmaceutically acceptable cations.
- 2. A methanediphosphonate derivative according to claim 1, wherein A in the formula (I) is --(CH.sub.2)a--(D)b--(CH.sub.2)c--.
- 3. A methanediphosphonate derivative according to claim 1 or 2 wherein A in the formula (I) is --(CH.sub.2)a--S--(CH.sub.2)c--.
- 4. A methanediphosphonate derivative according to claim 1 or 2 wherein A in the formula (I) is ##STR47## (wherein R.sup.5 represents a hydrogen atom or alkyl group).
- 5. A methanediphosphonate derivative according to claim 1 or 2, wherein A in the formula (I) is --(CH.sub.2)a--(CH.sub.2)b--(CH.sub.2)c--.
- 6. A methanediphosphonate derivative according to claim 1, wherein A in the formula (I) is --(CH.dbd.CH)d--CH.dbd..
- 7. A methanediphosphonate derivative according to claim 1, wherein X in the formula (I) is a hydrogen atom, or a straight chain or branched chain alkyl group having 1 to 8 carbon atoms.
- 8. (Amended) A methanediphosphonate derivative according to claim 1, wherein X in the formula (I) is a straight chain or branched chain alkyl group having 1 to 8 carbon atoms and is a substituted group(s).
- 9. A methanediphosphonate derivative according to claim 1, wherein X in the formula (I) is an aryl group.
- 10. A methanediphosphonate derivative according to claim 1, wherein a substituent on said straight chain or branched chain alkyl group is selected from the group consisting of methyl, ethyl, propyl, isopropyl, butyl, isobutyl, t-butyl, pentyl, hexyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclopentylrnethyl, cyclohexylmethyl, 2-aminoethyl, 2-N-methylaminoethyl, 2-N,N-dimethylaminoethyl, 2-hydroxyethyl, 2-alkoxyethyl, 2-trialkylsiloxyethyl, 2-aminopropyl, 2-N-methylaminopropyl, 2-N,N-dimethylaminopropyl, 3-aminopropyl, 3-N-methylaminopropyl, 3-N,N-dimethylaminopropyl, 2-hydroxypropyl, 2-alkoxypropyl and 2-trialkylsiloxyproopyl.
- 11. A methanediphosphonate derivative according to claim 1 wherein the atom other than carbon atom is selected from the group consisting of nitrogen, oxygen or silicon.
Priority Claims (2)
Number |
Date |
Country |
Kind |
3-22615 |
Sep 1991 |
JPX |
|
4-179802 |
Jul 1992 |
JPX |
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Parent Case Info
This application is a continuation of application Ser. No. 08/050,084, filed Apr. 28, 1993, now abandoned, which is a continuation of PCT/JP92/01140, filed Jul. 9, 1992, published as WO92/14297, Aug. 20, 1992.
US Referenced Citations (11)
Foreign Referenced Citations (6)
Number |
Date |
Country |
0243173A2 |
Oct 1987 |
EPX |
0407344A3 |
Jan 1991 |
EPX |
0416689A3 |
Mar 1991 |
EPX |
0440809A1 |
Aug 1991 |
EPX |
3044328 |
Feb 1991 |
JPX |
3106893 |
May 1991 |
JPX |
Continuations (1)
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Number |
Date |
Country |
Parent |
50084 |
Apr 1993 |
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