Claims
- 1. A method of treating a patient at risk of loss of cardiac function by cardiac ischemia, comprising(a) imaging the patient's heart, or a portion thereof, to identify (i) an underperfused region of cardiac muscle, (ii) a source of oxygenated blood that is proximate a boundary of the underperfused region, and (iii) a target area that includes said underperfused region boundary and a tissue expanse lying between said oxygenated blood supply and said boundary; and (b) at each of a plurality of sites throughout the target area, applying a tool effective to produce an annulus of injury about a core of healthy cells in the myocardial layer of the heart.
- 2. The method of claim 1, wherein the diameter of core of healthy tissue in the myocardial layer has a dimension of between about 1-4 mm.
- 3. The method of claim 1, wherein step (b) is carried out with a cutting tool that has a distal tissue-piercing end, and an annular cutting edge, by cutting through the epicardial or endocardial region of heart, to a depth of 1-4 mm into the underlying myocardium.
- 4. The method of claim 1, wherein step (b) is carried out with a cutting tool that has a distal tissue-piercing end, and a plurality of retractable cutting elements arrayed about said end, where the cutting elements can be retracted for insertion of the cutting tool into said target site, and deployed once in the target site.
- 5. The method of claim 1, wherein step (b) is carried out with a macerating tool that has (i) a distal tissue-piercing conical end piece defining a plurality of fluid-dispensing openings, and (ii) a fluid-injection conduit communicating with the end piece, wherein fluid supplied to the conduit under pressure, when the tool is positioned in the myocardium of the heart, is effective to produce tissue maceration in the vicinity of the end-piece openings.
Parent Case Info
This application claims priority of U.S. Provisional Patent Application Ser. No. 60/163,704 filed on Nov. 5, 1999, herein incorporated in its entirety by reference.
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