Microfluidic systems have been configured in various ways to move fluids through small channels. One configuration for channels where capillary forces dominate involves establishing a pressure differential between a point where the fluid is and a point where the fluid is to be moved. Other fluid pumps that address this problem of fluid flow utilize electrical, electrokinetic, or thermal forces to move fluids through microchannels. In instances where electrical driving forces are used, fluids may be moved through electrocapillary or electrowetting. In instances where electrokinetic forces are used, fluids may be moved through electrophoresis or electroosmosis. In addition, driving forces such as dielectrophoresis, electrohydrodynamic pumping, or magneto-hydrodynamic pumping are implemented by configuring electrodes and selecting and placing fluids within the microchannel in an appropriate manner.
For example, U.S. Pat. No. 5,632,876 utilizes electroosmosis and electrohydrodynamic principles, where wire electrodes are inserted into the walls of the channels at pre-selected intervals. As another example of fluid flow techniques, U.S. Pat. No. 6,949,176 uses capacitance forces to move fluid through a microchannel. In addition, the Knudsen pump, as described in U.S. Pat. No. 6,533,554 utilizes thermal transpiration for effecting gas flow.
However, there is a need for a fluid pump capable of efficient pumping of fluids, including gasses and liquids, which can have applications in small systems where capillary forces are not sufficient to create flow and Knudsen pumps are not workable.
Embodiments of the present invention provide efficient micro-pumping for small devices. In an embodiment a pipeline can be formed, asymmetrically coated with electrode patches. A small plasma can be generated in the vicinity of an exposed (powered) electrode to induce an electrohydrodynamic (EHD) body force, which can push a gas/liquid in particular direction. The electrodes can be arranged in the pipeline as electrode pairs. One embodiment can incorporate electrode pairs on the same surface and maintained at a potential bias using steady, pulsed direct, or alternating current. Another embodiment can incorporate electrode pairs separated by an insulative material where one electrode of the pair is powered with dc or ac operating at a radio frequency with respect to the other.
Pumping can be accomplished for electrically non-conductive fluids and for electrically conductive fluids. Embodiments used for pumping electrically non-conductive fluids can incorporate electrodes coated with a material having insulating properties, such as a dielectric, or can incorporate exposed electrodes. Embodiments used for pumping electrically conductive fluids can incorporate electrodes coated with a material having insulating properties, such as a dielectric material.
The arrangement of the electrodes in the pipeline can create, for example, straight or swirl pumping effects, or other desired pumping affects, by positioning the electrode pairs so as to provide forces in a manner to produce the desired pumping effect.
Micro-pumps in accordance with the invention can be used for pumping a variety of fluids, such as blood. The use of the subject micro-pumps can reduce, or substantially eliminate, shear forces on the surface of the micro-pump, resulting in a smooth flow. The reduction of shear for an embodiment of the subject micro-pump for pumping blood can reduce, or substantially eliminate breakage of blood particles during pumping due to shear forces with respect to the surface of the micro-pump in contact with the blood particles.
Embodiments of the present invention can provide efficient pumping of fluids, including liquids and gases, in small systems and devices. Pumping can be accomplished using electromagnetic principles including electrohydrodynamic (EHD) forces.
An EHD force can be used to pump fluid in a small conduit without any mechanical components. A micropump according to various embodiments of the present invention can be very useful for biomedical and chemical applications. For example, in one embodiment, the micropump can be used in place of conventional mechanical heart pumps, which have been found to create shear breakage of blood corpuscles. In another embodiment, the micropump can be used in patients with heart blockage. In addition, embodiments of the present invention can be used in aerospace and other applications. For example, embodiments incorporating surface electrical discharge at atmospheric pressure can be used for boundary layer flow actuation. The actuators of the micropump according to some embodiments of the present invention can operate using (pulsed) dc and ac power supply and can apply large electrohydrodynamic (EHD) forces in a relatively precise and self-limiting manner. Further embodiments can have rapid switch-on/off capabilities. Specific embodiments can operate without any moving parts. Embodiments of the invention have application in small systems where capillary forces are not sufficient to create flow and/or in situations where Knudsen pumps are not workable.
A variety of flow conduits and/or pipeline cross-sections can be implemented. Examples of cross-sections include, but are not limited to, circular, square, rectangular, polygonal, hexagonal, or parallel plates or curves.
The plates in the stack of plates in
In an embodiment, the powered electrodes can be exposed along the inner perimeter of the pipeline. In another embodiment, the powered electrodes can have a coating separating the powered electrode from the fluid. Various embodiments can be applied to any fluids that can be ionized, such as air, gases, and liquids. For electrically non-conductive fluids, the electrode of the electrode pair near the surface can be exposed to the fluid, but a cover can be positioned over the electrode if desired. For electrically conductive fluids, a cover, such as dielectric coating, can be placed over the electrode near the surface. This cover can improve safety.
In operation, a small plasma can be generated in the vicinity of the exposed (powered) electrode to induce an amount of electrohydrodynamic (EHD) body force to push gas/liquid in a certain direction. A magnetic field can also be used to induce additional magnetohydrodynamic (MHD) effect through Lorentz force. In a specific embodiment, the magnetic field can be oriented such that the current flow of the gas and/or liquid crossed with the direction of the magnetic field creates a force away from the surface of the pipeline, so as to pinch the gas and/or liquid along. The net result can be very efficient pumping of fluid from point A to point B in a system.
The electrode pairs can be powered and formed in various configurations.
In operation, electric forces can be generated between the electrodes. As the applied voltage becomes sufficiently large for a given interelectrode distance d and pressure p, the dielectric surface adjacent to the electrode can produce a surface discharge weakly ionizing the surrounding gas. In a specific embodiment, 1-20 kV peak-to-peak applied voltage with 2-50 kHz rf can be suitable for these actuators operating at atmospheric pressure. The plasma at this pressure is highly collisional, and can cause an efficient energy exchange between charged and neutral species. In this discharge, microfilaments of nanosecond duration with many current pulses in a half cycle can maintain the optical glow. Due to a combination of electrodynamic and collisional processes, charge separated particles induce the gas particles to move.
Specifics of the geometry of an embodiment example are given in the table below.
where w1 is width of the powered electrode, w2 is the width of the grounded electrode, d is the distance between the powered electrode and the grounded electrode, g is the actuator gap, h is the distance the powered electrode and the grounded electrode are kept apart by an insulator layer, b is the bore diameter, and P is the inner perimeter of the flow passage. It should be noted that the values stated in the above table can be adjusted as needed.
All patents, patent applications, provisional applications, and publications referred to or cited herein are incorporated by reference in their entirety, including all figures and tables, to the extent they are not inconsistent with the explicit teachings of this specification.
It should be understood that the examples and embodiments described herein are for illustrative purposes only and that various modifications or changes in light thereof will be suggested to persons skilled in the art and are to be included within the spirit and purview of this application.
The present application is the U.S. National Stage Application of International Patent Application No. PCT/US2008/071262, filed on Jul. 25, 2008, which claims the benefit of U.S. Provisional Application Ser. No. 60/951,839, filed Jul. 25, 2007, both of which are hereby incorporated by reference herein in their entirety, including any figures, tables, or drawings.
| Filing Document | Filing Date | Country | Kind | 371c Date |
|---|---|---|---|---|
| PCT/US2008/071262 | 7/25/2008 | WO | 00 | 1/14/2010 |
| Publishing Document | Publishing Date | Country | Kind |
|---|---|---|---|
| WO2009/015371 | 1/29/2009 | WO | A |
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