Embodiments of the invention relate to methods and apparatus for lossless, or low loss, coupling for many channel RF coil arrays. Specific embodiments pertain to methods and apparatus for magnetic resonance imaging (MRI).
The current trend in Magnetic Resonance Imaging (MRI) is to employ an ever greater number of radio frequency (RF) coils. Presently, the standard clinical MRI systems have 32 channels available for RF coil acquisition. With the advent of 32 channel clinical MR systems, and research systems with higher channel counts, many RF coil products and prototypes have been constructed to take advantage of the receiver hardware infrastructure. It has become clear that, in many cases, the signal-to-noise ratio (SNR) suffers if the coil element count is very high and the unit coils are small (Boskamp, E. B. et al., Proc. ISMRM, 2007, p. 1048, and Wiggins, G. C. et al. Proc. ISMRM, 2005, p. 671). This is particularly noticeable in volumetric arrays when compared with volume coils near the center of the array volume. The causes of these losses in SNR have been postulated to include unnecessary conductor losses, non-invertible noise coupling, shielding effects of many channels, and cable current losses (Wiggins, G. C. et al., Proc. ISMRM, 2007, p. 243). It would be advantageous to eliminate any or all of these effects.
Non-invertible noise coupling is a significant effect in SNR loss in many channel RF coil arrays. (Reykowski, Arne, et al., Rigid Signal-to-Noise Analysis of Coupled MRI Coils Connected to Noisy Preamplifiers and the Effect of Coil Decoupling on Combined SNR, Proc. ISMRM, 2000.) The state-of-the-art method for decoupling coil arrays utilizes a preamplifier that is severely power mismatched to the coil element (Roemer, et al.). This approach reduces the effect of mutual inductance by reducing the current in each coil element. This reduction is a result of a large impedance, which is usually primarily resistive, inserted into the coil loop as a result of attaching the preamplifier. While this method does not severely damage the SNR of a given coil, as the noise figures of the preamplifiers are typically less than 1 dB, it does lower the combined SNR (Signal to Noise Ratio) of an array of coil elements due to some preamplifier noise coupling from one element to another by means of shared impedances. For the coil element incorporating the preamplifier, the noise from the preamplifier is low with respect to the coil signal. However, for a second coil element that is coupled to the first the noise from the first coil's preamplifier can be dominant with respect to the noise energy coupled from the first coil to the second The same impedance that lowers the current and, thus, the inductive decoupling, becomes the dominant source of noise current that will circulate in the coil element. The method of utilizing a preamplifier that is power mismatched to the coil has been extremely successful in allowing effective multi-channel arrays. As the mismatch increases and the effective resistance in the loop increases, the coupling monotonically decreases. However, with increasing mismatch the relative percentage of noise from the preamplifier coupled to other elements in the array increases. The noise coupled from a first coil element to a second coil element is very different from the noise that emerges from the preamplifier on the first coil element. This fact makes complete removal of the effect of noise coupling impossible.
In this way, the use of a preamplifier that is power mismatched to the coil represents a limitation for many channel coil arrays. In a modern 32 element coil, a given element may have a small but measurable coupling effect with 20 or more other elements. Each of the coupled noise contributions from the preamplifiers are uncorrelated, since the noise sources associated with each preamplifier are uncorrelated from one preamplifier to another. Therefore, each loss in SNR adds approximately linearly with coupled noise power. The result is that mutual impedances that are adequate for a 4, or even 8 channel array, may not be sufficient for 32 or more small coil elements.
As discussed above, with multi-element systems, each coil element typically has a corresponding preamplifier. The preamplifier receives the signal from the coil and outputs a signal for processing by a receiver. In this way, the signal outputted to the receiver includes noise due to the resistance of the coil. This is because resistance generates thermal noise. Inductive coupling with nearby coils can increase the total noise output to the receiver from the preamplifier associated with the coil. Current approaches to reduce SNR losses can fail when coupling is strong and/or many coil elements are coupled. It appears that array coils with 32 or more elements are at a point where the effects of noise coupling from the preamplifiers via the coil element mutual impedance becomes significant.
Roemer et al. (Mag. Res. Med. 16, 192-225, 1990) demonstrated a basic inductive decoupling strategy. In addition also Roemer et al. described methods for simultaneously acquiring and subsequently combining NMR signals from a multitude of overlapping and closely positioned RF coil elements. For the NMR phased array taught by Roemer et al., adjacent coils are overlapped in order to minimize mutual inductance and each coil is connected to a highly impedance mismatched preamplifier producing a high impedance in the coil element to reduce the effect of mutual inductance between the coil elements that are not overlapped. Roemer et al. taught that the greater the impedance mismatch between coil and preamplifier and therefore the greater the impedance presented to the coil element, the greater the reduction of the effects of mutual impedances between the coil elements.
Since the introduction of this inductive decoupling technique by Roemer et al. efforts have been made to further increase the impedance mismatch between the preamplifier and the coil element. The typical preamplifiers used in current MRI systems have an mismatch ratio of approximately 50. Where the mismatch ratio is defined as the input impedance of the preamplifier divided by the impedance which is presented to the preamplifier by the coil element. This means that a coil element with an impedance of 2 ohms real can see approximately 100 ohms from the preamplifier. This dramatically increases the effective loop impedance from 4 ohms, for the powermatch preamplifier case which includes 2 ohms from the coil element and 2 ohms from the power matched amplifier, to 102 ohms using the impedance mismatched preamplifier. This results in a drop in voltage, induced in a second coil element through mutual inductance by a factor of approximately 25 for a constant voltage source in the first coil element. This is very effective for moderate inductive coupling between a relatively small number of coupled loops where the primary source of the coupled noise can be depicted as voltage sources in the loops. However, if the coupling is quite strong and/or the number of elements coupled is high, there is at least one aspect of the technique that can be problematic. The noise voltage that is transferred from this loop with effective impedance of 102 ohms originates mostly from the 100 ohms presented to the coil element by the preamplifier and not from the coil or sample. In the input referred noise model for preamplifiers, by Rothe and Dahlke (Rothe, H., Dahlke, W., Theory of Noisy Fourpoles, Proceedings of the Ire, June 1956, pp. 811-818.), the noise from the preamplifier can be modeled as a noise voltage source and a noise current source. While the noise coupling due to the preamplifier noise voltage source can be reduced by means of preamplifier decoupling, the coupling due to the preamplifier noise current source actually will increase with improved preamplifier decoupling. This effect can also be explained using a wave model that Penfield derived from the Rothe and Dahlke model. In this model by Penfield, there are two uncorrelated noise waves on the input side of the preamplifier. One noise wave is propagating towards the source (in our case the coil) where it is totally absorbed for the case of noise matching. The other wave is propagating towards the preamplifier where it is partially reflected due to the preamplifier input impedance. In case of noise matching only the wave propagating towards the preamplifier will add to the noise at the preamplifier output. Since preamplifier decoupling requires a high reflection coefficient between coil and preamplifier most of the noise wave propagating towards the preamplifier will be reflected at the preamplifier input and therefore also coupled to other coil elements. This form of noise coupling is also described in (Papoulis, A., Wave Representation of Amplifier Noise, Ire Transactions on Circuit Theory, pp. 84-86.) and (Duensing “Maximizing signal to noise ratio in the presence of coil coupling” J. Magn. Res. 111:230-235, 1996”). The result of this problem is that substantial coupling between many coils can result in unrecoverable losses in Signal-to-Noise ratio (SNR).
The coupling of noise and signal between two coils with low input impedance preamplifiers attached is very small. Suppose that both coils in
Without the second coil element present, the total impedance of the primary loop as viewed at terminal A is given by R1. With the second coil present and connected to a preamplifier of input impedance Rin(2) the impedance ZA as viewed from the terminals of the primary coil element is then given by
The second term is due to the mutual impedance between the two coil elements. If either the mutual impedance is made zero or the input impedance of the preamplifier is made very large, this second term approaches zero and the resultant impedance Rcoil(1) that of a single isolated coil at resonance.
The NMR signal transferred between two coils can be determined by the pen circuit voltage VA as viewed at terminal A, resulting in the following:
Accordingly, if the mutual inductance is very low or the preamplifier input impedance is very high, the open circuit voltage VA approaches the voltage received by the isolated primary coil element.
It therefore seems that increasing the input impedance of the preamplifier in the secondary coil element reduces the effect of mutual inductance on the signal output of the primary coil in the same way as reducing the mutual inductance does. However, the model of
Once again, if the mutual coupling k approaches 0 the open circuit voltage VA approaches that received by the isolated primary coil element. However, if the mutual inductance cannot be removed and, instead, preamplifier decoupling in (Rin(2)→∞) is employed to decrease the effects of mutual coupling than the open circuit voltage VA will be
V
A
=V
coil
(1)+(jω0Lcoilk)·in(2)
This means that there will be noise coupled from preamplifier 2 to preamplifier 1 as long as there is a significant mutual inductance ωLcoilk. This noise coupled from one coil element to another reduces the total combined SNR achievable with array coils when compared to the case where there is no mutual impedance between the coil elements present (see also Reykowski, Wang, “Rigid Signal-to-Noise Analysis of Coupled MRI Coils Connected to Noisy Preamplifiers and the Effect of Coil Decoupling on Combined SNR”, Proceedings of ISMRM 2000).
Still assuming that Rin(2)→∞ the voltage VB as viewed at terminal B is
V
B
=V
coil
(2)
+v
n
(2)
+R
coil
(2)
·i
n
(2)
=S
coil
(2)+(Ncoil(2)+vn(2)+Rcoil(2)·in(2))
where Scoil(2) is the MRI signal induced into coil element 2 and Ncoil(2) is the random thermal noise voltage due to losses in the sample and the coil. Since the preamplifiers typically add very little noise, most of the noise in VB will be due to sample and coil:
For a preamplifier with a noise figure of 0.5 dB, only 5% of the RMS noise at the output is due to the preamplifier, 95% is due to coil and sample losses. This also means that the noise (jω0Lcoilk)·in(2) coupled from coil element 2 to coil element 1 is highly uncorrelated from the noise (Ncoil(2)+vn(2)+Rcoil(2)·in(2)) that is measurable at the output of preamplifier 2. This means that the mechanism due to which noise emanating from a preamplifier attached to a second coil element and coupling into a first coil element is not invertible by post processing all output signals from all coil elements.
Accordingly, there is a need for a method and apparatus to reduce noise coupling between coils in many channel RF coil arrays.
Embodiments of the invention relate to methods and apparatus for lossless, or low loss, coupling for many channel RF coil arrays. Non-invertible noise can be converted to invertible noise. Specific embodiments pertain to methods and apparatus for magnetic resonance imaging (MRI) with many channel RF coil arrays. Specific embodiments pertain to methods and apparatus for matching one or more preamplifiers to associated coils in an MRI array and tuning the MRI coil array. Embodiments of the invention can incorporate matching of the coil to the impedance of the preamplifier.
Embodiments of the invention are advantageous for use with large channel counts. In a specific embodiment, the subject technique is applied to an array having at least 32 coils. In another specific embodiment, the subject technique is applied to an array having at least 64 coils. Another advantage of the subject invention is its use for unusual coil configurations.
Embodiments of the invention relate to a method of matching a plurality of coupled RF coils associated with a particular reconstruction algorithm. In an embodiment of the invention, inductive coupling can be permitted to occur between channels. The coupling, in moderate amounts, is not detrimental as long as it is measurable. In this embodiment, the noise in the channels can be made linearly related to the noise transferred between the channels. If linearity, preferably strict linearity, occurs, then inversion can be accomplished. Accurate measurement of the coupling signals permits algebraic inversion.
In another embodiment, referring to
The primary reason why the preamplifier decoupling method was developed by Roemer is that the coupling between coils can result in multiple modes (N coils produce N modes), generally at different frequencies. Using the preamplifier decoupling method by Roemer (i.e., providing a high impedance to the input terminals of each coil) reduces the effects of mode coupling between the coil elements.
Without preamplifier decoupling two coupled identical coils can have two associated modes at different frequencies. In an embodiment, the frequencies of the coils can be adjusted to bring one of the modes to the Larmor frequency. In this embodiment, bringing one of the modes to the Larmor frequency permits a good match and noise figure with the preamplifiers. This results in both channels being received by the system having nearly identical characteristics, i.e., both preamplifiers receive signal from the shared coupled mode in the same way that the two preamplifiers in
Z
opt
(1)
+Z
opt
(2)
=Z
Mode
Where Zopt(1) and Zopt(2) are the optimum noise match impedances for the two preamplifiers and ZMode is the mode impedance seen by one of the two preamplifiers if the other preamplifier is replaced with a short circuit.
In one embodiment, if the splitting between modes is not extremely large compared to the Q factors of the coils, then the behavior of the two ports at one of the resonant modes will not be exactly the same. For example, the two coupled coils referred to can have a mode that is associated with co-rotating current and a mode associated with counter-rotating current. In this embodiment, if the coil is tuned such that the Larmor frequency is at the co-rotating mode, for example, one would expect the outputs of both coils would be identical whether loop 1 was excited or loop 2 was excited. However, because the other mode is not infinitely far away and the Q's are not infinite, the output of loop 1, when loop 1 is driven, will generally be at least slightly higher than the output of loop 2. In addition, the phase will not be exactly the same. This small difference can be important with respect to the embodiment of the invention. If all of the possible modes are represented in the outputs of all of the coils, then it would generally be possible to reconstruct all of the modes from the outputs. To the extent that the noise coupling and signal coupling are identical, the inversion based on noise whitening also creates signal distributions associated with the resistive eigen-modes of the array. Standard (noise covariance) optimal reconstruction, as described in Roemer et al and Pruessmann et al (MRM 1999 SENSE: Sensitivity Encoding for Fast MRI), can be performed on the outputs of the coupled coils to produce the final image.
Referring to
The process of using preamplifier decoupling (i.e., Rin(2)→∞) can be lossy. When the mutual impedance between coil elements is strong, the noise transferred between coil elements is associated with the noise emanating from the front end of the preamplifiers and not the thermal noise from losses in the coil elements and sample. This is due to the fact that the current produced in a coil element from thermal noise due to losses in coil and sample will be significantly reduced through the use of preamplifier decoupling methods. However, the part of the noise current in a coil element that is due to the preamplifier front end is not a function of the total impedance of the combination of coil and preamplifier but rather a function of the magnitude of reflection coefficient between coil and preamplifier (see ref. Penfield). This fact prevents linear inversion and correction of the noise coupled between coil elements. However, when using the opposite strategy (i.e., Rin(2)→0), which we may term “preamplifier super-coupling”, the noise coupled between the two preamplifiers will be mainly due to losses in the coil elements and the sample. Moreover, the noise at the output of a preamplifier will be dominated by a component that is a linear function of the noise current on the attached coil element.
The assumption is that the SNR of the primary mode received with two preamplifiers can be recovered to an extent that is similar to receiving the same mode with a single preamplifier. At this point the question is whether additional signal received from the other mode(s) allows to increase the SNR even further or whether these mode(s) are too far off in frequency and, thus, too weak to be adequately sampled. For the specific case demonstrated, the loop mode was at 56.4 MHz, 7.5 MHz away and the loss compared to the standard decoupled case was severe, such that only about 50% of the SNR of that mode was obtained.
Specific embodiments involve a method and apparatus for converting non-invertible noise to invertible noise. Converting non-invertible noise to invertible noise can eliminate an impediment to the improvement of many channel arrays. Embodiments of the subject method for converting non-invertible noise to invertible noise to address non-invertible noise coupling can be used in situations where coupling is permissible but measurable. Accurate measurement of the coupling signals can permit algebraic inversion of the noise. Such algebraic inversion can be accomplished via, for example, optimal reconstruction, utilizing noise correlation measurements.
Consider the two coil system of
where S(1) and S(2) represent the signals for coil element 1 and coil element 2, respectively. N(1) and N(2) represent noise that originates within the first and second coil/sample systems, respectively. The noise N(1) originates from, for example, interaction of coil element 1 with the sample, from electronics within coil element 1, and from the coil element 1 conductor. The noise Nf1=vn(1)+Zcoil(1)in(1) is additional noise, which can be associated with the preamplifier and subsequent receive chain of channel 1.
The factors A and B are a function of the impedances in the network and only affect respective gains but not the resulting SNR's and noise correlations:
In the presence of coupling the two channels of data can be represented as:
where k12 represents the effective voltage coupling from coil element 1 to coil element 2, and k21 represents the effective voltage coupling from coil element 2 to coil element 1 Equation (7) represents the output from coil element 1 and equation (8) represents the output from coil element 2, when coil elements 1 and 2 are coupled through a shared impedance ZM. Note that with knowledge of k12 and k21 one can eliminate part of the coupled components during post processing by making use of an inversion of the voltage coupling matrix K:
Note also that preamplifier decoupling (Zin(i)→∞) will make the voltage coupling coefficients vanish. But neither post processing techniques nor preamplifier decoupling will remove the terms in equations (7) and (8) that are due to noise current coupling:
Nf3=ZMin(1) Nf4=ZMin(2)
The ability of using high input impedance preamplifiers to reduce the effects of mutual impedance is inevitably tied to the fact that the output of the coil element is not deteriorated by the inserted high preamplifier input impedance, but the remaining circulating noise current that causes residual coupling to other coil elements is dominated by noise emanating from the preamplifier.
If one could obtain a measurement of Nf3 and Nf4, then it would be possible to invert the coupling.
The following approach is designed to obtain some knowledge of Nf3 and Nf4 with the objective to reduce the effect of noise coupling between coil elements. In this approach two preamplifiers can be attached to each coil element. The output signals of these preamplifiers can be combined into two modes. The first mode can contain a signal with an SNR equivalent to what would be expected from a single noise matched preamplifier attached to the coil. The second mode can contain noise information that can allow for the reduction of the effect of noise coupled between the elements. This combination can either be done in hardware, software, or by using an optimal reconstruction algorithm (Roemer et al).
Preamplifier 1 has input impedance Zin(1) and optimum noise match impedance Zopt(1), preamplifier 2 has input impedance Zin(2) and optimum noise match impedance Zopt(2). It can be shown that the SNR obtainable from a weighted combination (=first mode) of the output signals from both preamplifiers is the same as the SNR obtained from a single noise matched preamplifier with otherwise identical noise parameters as long as Zopt(1)+Zopt(2)=Zcoil.
If preamplifier 1 has a very high input impedance (=preamplifier decoupling) and preamplifier 2 has a very low impedance (=preamplifier super coupling) than the noise current on the coil will be mainly due to the noise current source in(1) of preamplifier 1. It can now be shown that with appropriate weighted combination of the preamplifier outputs a second mode can be created that is proportional to in(1)-in(2). Knowledge of this second mode should therefore permit the reduction of the effect of noise coupling to other coil elements.
Both i(1) and in(2) are inverse proportional to the magnitude of the respective optimum noise match impedances Zopt(1) and Zopt(2).
It therefore follows that for
|Zopt(1)|<<|Zopt(2)|in(1)|2>>in(2)|2
Under these circumstances the second mode would be very similar to the noise current on the coil element.
The input referred noise model was introduced by Rothe and Dahlke (Proceedings of the IRE 1956 page 811) in 1956. This model consists of a noiseless preamplifier along with a series voltage source and a shunt current source on the input. This is shown in
We can consider the coil shown in
In this way, in specific embodiments, the form of the coupling is determined rather than the magnitude of the coupling. The signal plus noise coming out of the coil can be measured, for example via a second preamplifier, instead of further reducing the coupling coefficients. In this way, the noise out of the first preamplifier is measured by the second preamplifier. Accordingly, embodiments of the invention can reduce the need to lower the coupling to the lowest levels. Processing can be accomplished via hardware and/or software.
To test the ability of this second preamplifier to allow near lossless inversion of coupled signal and noise, two coils, were coupled to one another as shown in
In various embodiments, other devices can be used in place of preamplifier 2. In a specific embodiment, an amplifier can be put in the loop so as to be physically attached. In another embodiment, a pick up loop that is not physically attached to the loop, but picks up signal and noise by coupling, can be used. In another embodiment, a small probe coil can be positioned near the loop and the probe coil can have a preamplifier.
Embodiments of the invention relate to a method and apparatus for imaging using multiple coils, incorporating a measurement of coil current. This measurement of coil current can be valuable in reducing SNR losses due to residual coupling to other coils. Embodiments can be applied to coil configurations where there are many coils with weak coupling. Further embodiments can optimize the impedance of preamplifier 2 and can reduce the loss due to preamplifier 2.
All patents, patent applications, provisional applications, and publications referred to or cited herein are incorporated by reference in their entirety, including all figures and tables, to the extent they are not inconsistent with the explicit teachings of this specification.
It should be understood that the examples and embodiments described herein are for illustrative purposes only and that various modifications or changes in light thereof will be suggested to persons skilled in the art and are to be included within the spirit and purview of this application.
The present application claims the benefit of U.S. Provisional Application Ser. No. 61/005,657, filed Dec. 6, 2007, which is hereby incorporated by reference herein in its entirety, including any figures, tables, or drawings.
Number | Date | Country | |
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61005657 | Dec 2007 | US |