The present invention relates to a method and an apparatus for manufacturing a three-dimensional article with porosity.
Additive manufacturing is a method for forming three-dimensional articles through successive fusion of chosen parts of powder layers applied to a worktable.
Such an apparatus may comprise a work table on which the three-dimensional article is to be formed, a powder dispenser, arranged to lay down a thin layer of powder on the work table for the formation of a powder bed, an energy beam source for delivering energy to the powder whereby fusion of the powder takes place, elements for control of the energy given off by the energy beam source over the powder bed for the formation of a cross section of the three-dimensional article through fusion of parts of the powder bed, and a controlling computer, in which information is stored concerning consecutive cross sections of the three-dimensional article. A three-dimensional article is formed through consecutive fusions of consecutively formed cross sections of powder layers, successively laid down by the powder dispenser.
Three-dimensional network structures may be used in body implant articles such as bone replacements. In recent years artificial bone implants may have a solid core with a surface layer having a network structure. The network structure improves the bone/tissue in-growth capability and thereby strengthens the connection between the human bone and the artificial bone implant. The material used in the network structures may for instance be Titanium, which is a well proven material to be compatible with the human body tissue. Titanium is a relatively light and strong material. An implant may efficiently aggregate to the human body if the network structure is as human like as possible.
One way of enhancing the effectiveness of an orthopedic implant may be to randomize the porous structure of an implant so it better simulates trabecular structures in which it is implanted. One way of doing so is disclosed in WO 2011/060311 relating to a controlled randomized porous structures and methods for making the same. In the document it is disclosed a method for randomizing the network structure in order to meet the above mentioned needs. WO 2011/060311 discloses a method for seamlessly joining randomized units with improved porosity without sacrificing the strength of the final implant article.
One problem with the solution is that the manufacturing process is relatively CPU and memory consuming. Another problem with the solution is that there is some degree of periodicity in the porosity of the final article which may cause mechanical strength limitations.
Having this background, an object of the invention is to provide a method for an additive manufacturing process for manufacturing three dimensional articles with improved randomized porosity while minimizing the CPU and memory usage. The above mentioned object is achieved by the features in the claims provided herein.
In one aspect of the invention, it is provided a computer program product comprising at least one non-transitory computer-readable storage medium having computer-readable program code portions embodied therein, the computer-readable program code portions comprising one or more executable portions configured for: creating a model of a non-porous three-dimensional article comprising a predetermined number of layers with a predetermined thickness; and creating a model of a porous structure, said creating step comprising the steps of: defining a completely randomized three-dimensional space comprising a randomized arrangement of nodes, said randomized arrangement of nodes defined by the steps of: a. identifying a predetermined number of said nodes initially arranged randomly in the three-dimensional space of predetermined size; b. determining a maximum number of neighbor nodes to a specific node; c. skipping a number x of closest neighbors to said specific node where x is a random integer number being ≥0; d. connecting each of said maximum neighbor nodes, with the exception of the skipped nodes, to said specific node with a strut; and e. repeating steps a-d for each node in the three-dimensional space, wherein said randomized arrangement of nodes lacks periodicity, such that due to the lacking periodicity, a mechanical strength of a porous structure created therefrom is equal in all directions; slicing said completely randomized three-dimensional space into a predetermined number of layers with a predetermined thickness; applying one layer of said model of the non-porous three-dimensional article on one layer of said randomized three-dimensional space resulting in a model of a porous layer of said porous three-dimensional article; and repeating said applying step for all layers of said model of the non-porous three-dimensional article. The one or more executable portions are further configured for manufacturing the porous three-dimensional article by selectively exposing fusible material to an energy source, so that a layer of fused material corresponds to the model of the porous layer of said porous three-dimensional article.
In another exemplary aspect of the invention it is provided a method for manufacturing a porous three-dimensional article. The method comprising the steps of creating a model of a non-porous three-dimensional article comprising a predetermined number of two-dimensional layers with a predetermined thickness, creating a model of a porous structure comprising the steps of: defining a three-dimensional space comprising a randomized pattern of nodes, wherein the nodes are connected together in a predetermined manner with struts, slicing the three-dimensional space into a predetermined number of two-dimensional layers with a predetermined thickness, applying one two-dimensional layer of the model of non-porous three-dimensional article on one two-dimensional layer of the porous structure resulting in a porous two-dimensional layer of the article, repeating the applying step for all non-porous two-dimensional layers of the article, manufacturing the porous three-dimensional article by exposing fusible material to an energy source, so that a layer of fused material is corresponding to a porous two-dimensional layer of the article.
An advantage of the present invention is that a final porous three-dimensional article can be manufactured which has a porous structure which is randomized in every direction, i.e., the porosity lacks periodicity meaning that the mechanical strength of the porosity is equal in all directions.
In another example embodiment the randomized pattern is defined by moving a predetermined number of nodes in a regular pattern of tetrahedrons, cubes or dodecahedrons a randomized distance, which distance is less than a predetermined value and in a randomized direction.
In an example embodiment the predetermined number of nodes is all nodes.
In still another example embodiment the randomized pattern is defined by the steps of: a. providing a predetermined number of nodes randomly in a 3-dimensional space of predetermined size, b. determining a maximum number of neighbor nodes to a specific node, c. skipping a number x of closest neighbors to the specific node where x is a random integer number being d. connecting each of the maximum neighbor nodes to the specific node with a strut, repeating step a-d for each node in the 3-D space.
In yet another example embodiment the randomized pattern is defined by the steps of: a. providing randomly a predetermined number of nodes in the three-dimensional space, b. providing the nodes in a Delauney-triangulation giving a predetermined number of Delauney-tetrahedrons, c. providing a Voronoi diagram for each Delauny-tetrahedron connecting a centre of a circumsphere of the Delauny-tetrahedron with the centers of circumspheres for all neighbors of the Delauny-tetrahedron.
An advantage with these embodiments is that the randomized patterns are relatively quickly to produce with a relatively small amount of computer power.
In another example embodiment of the present invention the manufacturing step comprising the steps of: a. providing a layer of powder material on a build platform, b. adapting the thickness of the powder material layer to the thickness of the predetermined thickness of the two-dimensional layer of the article.
An advantage with this embodiment is that the model and manufacturing process are connected to each other resulting in a more precisely manufactured three-dimensional articles. In an example embodiment there may not be an exact correspondence between the thickness of the model layer and the thickness of the powder layer. There might be a scaling factor between the model layer and powder layer depending inter alia on the dimension of the powder particles and/or the type of powder used.
In another aspect of the present invention it is provided an apparatus for manufacturing a three-dimensional article with porosity comprising: means for creating a model of a non-porous three-dimensional article comprising a predetermined number of two-dimensional layers with a predetermined thickness, means for creating a model of a porous structure comprising the steps of: defining a three-dimensional space comprising a randomized pattern of nodes, wherein the nodes are connected together in a predetermined manner with struts, slicing the three-dimensional space into a predetermined number of two-dimensional layers with a predetermined thickness, applying one two-dimensional layer of the model of non-porous three-dimensional article on one two-dimensional layer of the porous structure resulting in a porous two-dimensional layer of the article, repeating the applying step for all non-porous two-dimensional layers of the article, means for manufacturing the porous three-dimensional article by exposing fusible material to an energy source, so that a layer of fused material is corresponding to a porous two-dimensional layer of the article.
An advantage of the present inventive apparatus is that a final porous three-dimensional article can be manufactured which has a porous structure which is randomized in every direction, i.e., the porosity lacks periodicity meaning that the mechanical strength of the porosity is equal in all directions.
Further advantages and advantageous features of the invention are disclosed in the following description and in the claims provided herein.
Having thus described the invention in general terms, reference will now be made to the accompanying drawings, which are not necessarily drawn to scale, and wherein:
Various embodiments of the present invention will now be described more fully hereinafter with reference to the accompanying drawings, in which some, but not all embodiments of the invention are shown. Indeed, embodiments of the invention may be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will satisfy applicable legal requirements. Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly known and understood by one of ordinary skill in the art to which the invention relates. The term “or” is used herein in both the alternative and conjunctive sense, unless otherwise indicated. Like numbers refer to like elements throughout.
Still further, to facilitate the understanding of this invention, a number of terms are defined below. Terms defined herein have meanings as commonly understood by a person of ordinary skill in the areas relevant to the present invention. Terms such as “a”, “an” and “the” are not intended to refer to only a singular entity, but include the general class of which a specific example may be used for illustration. The terminology herein is used to describe specific embodiments of the invention, but their usage does not delimit the invention, except as outlined in the claims.
The term “three-dimensional structures” and the like as used herein refer generally to intended or actually fabricated three-dimensional configurations (e.g. of structural material or materials) that are intended to be used for a particular purpose. Such structures, etc. may, for example, be designed with the aid of a three-dimensional CAD system.
The term “electron beam” as used herein in various embodiments refers to any charged particle beam. The source of a charged particle beam can include an electron gun, a linear accelerator and so on.
The apparatus 21 comprising an electron beam gun 6; deflection coils 7; two powder hoppers 4, 14; a build platform 2; a build tank 10; a powder distributor 28; a powder bed 5; and a vacuum chamber 20.
The vacuum chamber 20 is capable of maintaining a vacuum environment by means of a vacuum system, which system may comprise a turbomolecular pump, a scroll pump, an ion pump and one or more valves which are well known to a skilled person in the art and therefore need no further explanation in this context. The vacuum system is controlled by a control unit 8.
The electron beam gun 6 is generating an electron beam which is used for melting or fusing together powder material provided on the build platform 2. At least a portion of the electron beam gun 6 may be provided in the vacuum chamber 20. The control unit 8 may be used for controlling and managing the electron beam emitted from the electron beam gun 6. At least one focusing coil (not shown), at least one deflection coil 7 and an electron beam power supply (not shown) may be electrically connected to the control unit 8. In an example embodiment of the invention the electron beam gun 6 generates a focusable electron beam with an accelerating voltage of about 15-60 kV and with a beam power in the range of 3-10 Kw. The pressure in the vacuum chamber may be 10−3 mBar or lower when building the three-dimensional article by fusing the powder layer by layer with the energy beam.
The powder hoppers 4, 14 comprise the powder material to be provided on the build platform 2 in the build tank 10. The powder material may for instance be pure metals or metal alloys such as titanium, titanium alloys, aluminum, aluminum alloys, stainless steel, Co—Cr—W alloy, etc.
The powder distributor 28 is arranged to lay down a thin layer of the powder material on the build platform 2. During a work cycle the build platform 2 will be lowered successively in relation to the ray gun after each added layer of powder material. In order to make this movement possible, the build platform 2 is in one embodiment of the invention arranged movably in vertical direction, i.e., in the direction indicated by arrow P. This means that the build platform 2starts in an initial position, in which a first powder material layer of necessary thickness has been laid down. Means for lowering the build platform 2 may for instance be through a servo engine equipped with a gear, adjusting screws etc.
An energy beam may be directed over the build platform 2 causing the first powder layer to fuse in selected locations to form a first cross section of the three-dimensional article. The energy beam may be an electron beam or a particle beam. The beam is directed over the build platform 2 from instructions given by the control unit 8. In the control unit 8 instructions for how to control the beam gun for each layer of the three-dimensional article is stored.
After a first layer is finished, i.e., the fusion of powder material for making a first layer of the three-dimensional article, a second powder layer is provided on the build platform 2. The second powder layer is preferably distributed according to the same manner as the previous layer. However, there might be alternative methods in the same additive manufacturing machine for distributing powder onto the work table. For instance, a first layer may be provided by means of a first powder distributor 28, a second layer may be provided by another powder distributor. The design of the powder distributor is automatically changed according to instructions from the control unit 8. A powder distributor 28 in the form of a single rake system, i.e., where one rake is catching powder fallen down from both a left powder hopper 4 and a right powder hopper 14, the rake as such can change design.
After having distributed the second powder layer on the build platform 2, the energy beam is directed over the work table causing the second powder layer to fuse in selected locations to form a second cross section of the three-dimensional article. Fused portions in the second layer may be bonded to fused portions of the first layer. The fused portions in the first and second layer may be melted together by melting not only the powder in the uppermost layer but also remelting at least a fraction of a thickness of a layer directly below the uppermost layer.
In the case where an electron beam is used, it is necessary to consider the charge distribution that is created in the powder as the electrons hit the powder bed 5. The invention is, at least partly, based on the realization that the charge distribution density depends on the following parameters: beam current, electron velocity (which is given by the accelerating voltage), beam scanning velocity, powder material and electrical conductivity of the powder, i.e. mainly the electrical conductivity between the powder grains. The latter is in turn a function of several parameters, such as temperature, degree of sintering and powder grain size/size distribution.
Thus, for a given powder, i.e. a powder of a certain material with a certain grain size distribution, and a given accelerating voltage, it is possible, by varying the beam current (and thus the beam power) and the beam scanning velocity, to affect the charge distribution.
By varying these parameters in a controlled way, the electrical conductivity of the powder can gradually be increased by increasing the temperature of the powder. A powder that has a high temperature obtains a considerably higher conductivity which results in a lower density of the charge distribution since the charges quickly can diffuse over a large region. This effect is enhanced if the powder is allowed to be slightly sintered during the pre-heating process. When the conductivity has become sufficiently high, the powder can be fused together, i.e. melted or fully sintered, with predetermined values of the beam current and beam scanning velocity.
In a first embodiment of a method for manufacturing a porous three-dimensional article, a model is created of a non-porous three-dimensional article comprising a predetermined number of two-dimensional layers with a predetermined thickness. This non-porous model may for instance be made in a computer aided design (CAD) tool. The two-dimensional layers in the three-dimensional article may be made by slicing the three-dimensional article by a slicing tool, for instance Magics or Infinity Slicer. The non-porous three dimensional article has an outer boundary which is the same as an outer boundary of the porous final three-dimensional article, i.e., the only difference between the porous article to be manufactured and the non-porous three dimensional article lies in the porosity. It is relatively easy to make a three-dimensional design of an article which is solid in a CAD program. However, it is more difficult to make the same three-dimensional article with a randomized porosity in the same CAD program.
In a next step a model is created of a porous structure. The modelling comprising a first step of defining a three-dimensional space comprising a randomized pattern of nodes, wherein the nodes are connected together in a predetermined manner with struts.
In a first example embodiment the three-dimensional space is defined by providing a regular three-dimensional pattern of nodes. The regular pattern of nodes may for instance be made of tetrahedrons, cubes or dodecahedrons, where the nodes are provided in corners and connected together in a predetermined way by struts to form regular three-dimensional structures. A distance between two nodes in the regular pattern of nodes is predetermined and can be chosen arbitrarily by an operator.
The network structure in
Each and every node 330 is thereafter moved a randomized distance, which distance is less than a predetermined value and in a randomized direction. This will destroy the regularity of the original structure. In
In a second example embodiment the three-dimensional space is defined by firstly providing a predetermined number of nodes randomly in a 3-dimensional space of a predetermined size.
Secondly a maximum number of neighbor nodes to a specific node is determined. This maximum number may be any positive integer between 1-∞.
Thirdly a number x of closest neighbors to the specific node is skipped. X may be a random positive integer number being ≥0. Being skipped should here be interpreted as ignoring those x nodes which is/are closest to a given node.
Fourthly, each of the maximum neighbor nodes, except those nodes that might have been skipped, are connected to the specific node with a strut. Step a-d is repeated for each node in the 3-dimensional space.
In a third example embodiment the three-dimensional space is defined by firstly providing a predetermined number of nodes randomly in a 3-dimensional space of a predetermined size.
Secondly the nodes are provided in a Delauney-triangulation giving a predetermined number of Delauney-tetrahedrons. In an example embodiment the tetrahedrons are provided with smallest angles connecting the nodes, i.e., the first derivative of two struts connected together via a node is continuous.
Thirdly a Voronoi diagram is provided by for each Delauny-tetrahedron connecting the centre of the circumsphere of the Delanuney-tetrahedron with the centres of the circumspheres for all the neighbors of the Delauney-tetrahedron. The method of constructing a randomized network according to this principle is well known in the art and could be studied in for instance “Randomized incremental construction of Delaunay and Voronoi diagrams” by Leonidas J. Guibas, Donald E. Knuth and Micha Sharir.
In a second step the three-dimensional space is sliced into a predetermined number of two-dimensional layers with a predetermined thickness. The two dimensional layers could be sliced at an arbitrarily plane in the three-dimensional space. The number of two-dimensional planes building up the three-dimensional space is depending on the thickness of the two dimensional planes, the smaller the thickness of the planes the larger the number of planes it takes to build the complete three-dimensional space.
In a third step one two-dimensional layer of the model of non-porous three-dimensional article is applied on one two-dimensional layer of the porous structure resulting in a porous two-dimensional layer of the article. An example embodiment of this is illustrated in
The meaning of applying one two-dimensional layer of the model of non-porous three-dimensional article on one two-dimensional layer of the porous structure resulting in a porous two-dimensional layer of the article is to use a Boolean operation resulting in deletion of the porous structure outside the model of the non porous two-dimensional layer 620 and a creation of a porous structure inside the model of the non porous two-dimensional layer 620, i.e., the two-dimensional layer of the model of non-porous three-dimensional article has become a porous two-dimensional layer of the three-dimensional article denoted by 630in
In a fourth step the applying step is repeated for all two-dimensional layers of the article in order to create a complete porous 3-dimensional model of the article to be manufactured.
The porous three-dimensional article is manufactured by exposing fusible material to an energy source, so that a layer of fused material is corresponding to a porous two-dimensional layer of the article.
In another example embodiment a layer of powder material is provided on a build platform 2. The thickness of the powder material layer is adapted to the thickness of the predetermined thickness of the two-dimensional layer of the article. When deciding upon the thickness of the two-dimensional layers in the model, the thickness is corresponding to the thickness of the actual powder layer out of which the final three-dimensional article is to be made of.
The powder material may be made of metal for instance titanium, titanium alloys, Co—Cr alloys, nickel based superalloys, aluminium, aluminium alloys, etc.
The energy source may be an electron beam source, a laser source or a particle beam source.
A first derivative of at least one connection between two struts may be continuous. This is illustrated in a 2-dimensional case in
In an example embodiment of the present invention an approximated Voronoi diagram may be used instead of the above mentioned Voronoi diagram.
In an example embodiment of the present invention a randomized pattern of point may be generated inside a volume of the porous three-dimensional object to be manufactured. This may be useful if the outer shape of the manufactured three-dimensional article need not to be identical with the model of the porous three-dimensional article. Since the randomized pattern is generated inside the volume of the three-dimensional object, it is highly likely that the outer surface in the actual manufactured article is lying inside the model of the porous three-dimensional article. The reason for this is that the very few of the randomized pattern of points may be provided exactly on the boarder of the three-dimensional article.
In an example embodiment the struts which may connect the points may be a volume element, an area element or a linear element. An area element may be flat and the linear element may be a one dimensional line.
In the fusion process such lines or points are melted as lines or points or as a 2-dimensional figure around the point or line, e.g., like small circles or ovals.
In an example embodiment a linear element may be inclined with an angle α with respect to a slicing surface, where 15°≤α≤165°. In an example embodiment a linear element may be inclined with an angle a with respect to a slicing surface, where 10°≤α≤170°. If a line which may connect two points lying in two different and adjacent layers is horizontal or almost horizontal, such a line may not connect the two points in the two layers after the slicing procedure and/or the manufacturing procedure.
In still another example embodiment a maximum and minimum value of the angle a may be dependent on the thickness of the slicing layer.
In an example embodiment of the present invention it is provided a method for manufacturing a porous three-dimensional article comprising the steps of: creating a model of a non-porous three-dimensional article comprising a predetermined number of two-dimensional layers with a predetermined thickness, creating a model of a porous structure comprising the steps of: defining a three-dimensional space, larger or equal to the non-porous three-dimensional space, comprising a randomized pattern of nodes, wherein the nodes are connected together in a predetermined manner with struts. Slicing the three-dimensional space into a predetermined number of two-dimensional layers with a predetermined thickness, and if necessary applying one two-dimensional layer of the model of non-porous three-dimensional article on one two-dimensional layer of the porous structure resulting in a porous two-dimensional layer of the article. Repeating the applying step for all non-porous two-dimensional layers of the article, manufacturing the porous three-dimensional article by exposing fusible material to an energy source, so that a layer of fused material is corresponding to a porous two-dimensional layer of the article.
In still another example embodiment of the present invention the struts may either be described by volume, area or line elements or by any combination of these elements.
In still another example embodiment of the present invention the porous two-dimensional layers of the article may be described by either the 2D polygon data created from slicing the volume elements or of 2D line data created from slicing the area elements or of 2D point data created from slicing line elements or by any combination of these three sets of data.
In yet another example embodiment of the present invention the 2D line data and 2D point data in the porous two-dimensional layers of the article may be expanded to a predetermined 2D polygon data located at a predetermined position relative to the 2D line data or to the 2D point data.
The invention is not limited to the above-described embodiments and many modifications are possible within the scope of the following claims. Such modifications may, for example, involve using a different source of ray gun than the exemplified electron beam such as laser beam. Other materials than metallic powder may be used such as powder of polymers or powder of ceramics.
The invention is not limited to the above-described embodiments and many modifications are possible within the scope of the following claims.
This application is a continuation application of and claims priority to and the benefit of U.S. Nonprovisional application Ser. No. 14/350,767, filed Dec. 18, 2012, which application is a national stage application, filed under 35 U.S.C. § 371, of International Application No. PCT/EP2012/076025, filed Dec. 18, 2012, which application further claims priority to U.S. Provisional Application No. 61/580,775, filed Dec. 28, 2011, the contents of all of which as are hereby incorporated by reference in their entirety.
Number | Name | Date | Kind |
---|---|---|---|
2264968 | De Forest | Dec 1941 | A |
2323715 | Kuehni | Jul 1943 | A |
3634644 | Ogden et al. | Jan 1972 | A |
3838496 | Kelly | Oct 1974 | A |
3882477 | Mueller | May 1975 | A |
3906229 | Demeester et al. | Sep 1975 | A |
3908124 | Rose | Sep 1975 | A |
4314134 | Schumacher et al. | Feb 1982 | A |
4348576 | Anderl et al. | Sep 1982 | A |
4352565 | Rowe et al. | Oct 1982 | A |
4401719 | Kobayashi et al. | Aug 1983 | A |
4541055 | Wolfe et al. | Sep 1985 | A |
4651002 | Anno | Mar 1987 | A |
4818562 | Arcella et al. | Apr 1989 | A |
4863538 | Deckard | Sep 1989 | A |
4888490 | Bass et al. | Dec 1989 | A |
4927992 | Whitlow et al. | May 1990 | A |
4958431 | Clark et al. | Sep 1990 | A |
4988844 | Dietrich et al. | Jan 1991 | A |
5118192 | Chen et al. | Jun 1992 | A |
5135695 | Marcus | Aug 1992 | A |
5167989 | Dudek et al. | Dec 1992 | A |
5182170 | Marcus et al. | Jan 1993 | A |
5204055 | Sachs et al. | Apr 1993 | A |
5247560 | Hosokawa et al. | Sep 1993 | A |
5393482 | Benda et al. | Feb 1995 | A |
5483036 | Giedt et al. | Jan 1996 | A |
5508489 | Benda et al. | Apr 1996 | A |
5511103 | Hasegawa | Apr 1996 | A |
5595670 | Mombo-Caristan | Jan 1997 | A |
5647931 | Retallick et al. | Jul 1997 | A |
5753274 | Wilkening et al. | May 1998 | A |
5837960 | Lewis et al. | Nov 1998 | A |
5876550 | Feygin et al. | Mar 1999 | A |
5904890 | Lohner et al. | May 1999 | A |
5932290 | Lombardi et al. | Aug 1999 | A |
6046426 | Jeantette et al. | Apr 2000 | A |
6162378 | Bedal et al. | Dec 2000 | A |
6204469 | Fields et al. | Mar 2001 | B1 |
6419203 | Dang | Jul 2002 | B1 |
6537052 | Adler | Mar 2003 | B1 |
6554600 | Hofmann et al. | Apr 2003 | B1 |
6583379 | Meiners et al. | Jun 2003 | B1 |
6676892 | Das et al. | Jan 2004 | B2 |
6724001 | Pinckney et al. | Apr 2004 | B1 |
6746506 | Liu et al. | Jun 2004 | B2 |
6751516 | Richardson | Jun 2004 | B1 |
6764636 | Allanic et al. | Jul 2004 | B1 |
6811744 | Keicher et al. | Nov 2004 | B2 |
6815636 | Chung et al. | Nov 2004 | B2 |
6824714 | Türck et al. | Nov 2004 | B1 |
7003864 | Dirscherl | Feb 2006 | B2 |
7020539 | Kovacevic et al. | Mar 2006 | B1 |
7165498 | Mackrill et al. | Jan 2007 | B2 |
7204684 | Ederer et al. | Apr 2007 | B2 |
7291002 | Russell et al. | Nov 2007 | B2 |
7452500 | Uckelmann | Nov 2008 | B2 |
7454262 | Larsson et al. | Nov 2008 | B2 |
7537722 | Andersson et al. | May 2009 | B2 |
7540738 | Larsson et al. | Jun 2009 | B2 |
7569174 | Ruatta et al. | Aug 2009 | B2 |
7635825 | Larsson | Dec 2009 | B2 |
7686605 | Perret et al. | Mar 2010 | B2 |
7696501 | Jones | Apr 2010 | B2 |
7713454 | Larsson | May 2010 | B2 |
7754135 | Abe et al. | Jul 2010 | B2 |
7799253 | Höchsmann et al. | Sep 2010 | B2 |
7871551 | Wallgren et al. | Jan 2011 | B2 |
8021138 | Green | Sep 2011 | B2 |
8083513 | Montero-Escuder et al. | Dec 2011 | B2 |
8137739 | Philippi et al. | Mar 2012 | B2 |
8187521 | Larsson et al. | May 2012 | B2 |
8308466 | Ackelid et al. | Nov 2012 | B2 |
8992816 | Jonasson et al. | Mar 2015 | B2 |
9073265 | Snis | Jul 2015 | B2 |
9079248 | Ackelid | Jul 2015 | B2 |
9126167 | Ljungblad | Sep 2015 | B2 |
9254535 | Buller et al. | Feb 2016 | B2 |
9310188 | Snis | Apr 2016 | B2 |
9505172 | Ljungblad | Nov 2016 | B2 |
9550207 | Ackelid | Jan 2017 | B2 |
9802253 | Jonasson | Oct 2017 | B2 |
9950367 | Backlund et al. | Apr 2018 | B2 |
10071422 | Buller et al. | Sep 2018 | B2 |
20020104973 | Kerekes | Aug 2002 | A1 |
20020152002 | Lindemann et al. | Oct 2002 | A1 |
20020195747 | Hull et al. | Dec 2002 | A1 |
20030043360 | Farnworth | Mar 2003 | A1 |
20030133822 | Harryson | Jul 2003 | A1 |
20030205851 | Laschutza et al. | Nov 2003 | A1 |
20040012124 | Li et al. | Jan 2004 | A1 |
20040026807 | Andersson et al. | Feb 2004 | A1 |
20040084814 | Boyd et al. | May 2004 | A1 |
20040104499 | Keller | Jun 2004 | A1 |
20040148048 | Farnworth | Jul 2004 | A1 |
20040173496 | Srinivasan | Sep 2004 | A1 |
20040173946 | Pfeifer et al. | Sep 2004 | A1 |
20040204765 | Fenning et al. | Oct 2004 | A1 |
20040217095 | Herzog | Nov 2004 | A1 |
20050173380 | Carbone | Aug 2005 | A1 |
20050186538 | Uckelmann | Aug 2005 | A1 |
20050282300 | Yun et al. | Dec 2005 | A1 |
20060108712 | Mattes | May 2006 | A1 |
20060138325 | Choi | Jun 2006 | A1 |
20060145381 | Larsson | Jul 2006 | A1 |
20060147332 | Jones et al. | Jul 2006 | A1 |
20060157892 | Larsson | Jul 2006 | A1 |
20060180957 | Hopkinson et al. | Aug 2006 | A1 |
20060284088 | Fukunaga et al. | Dec 2006 | A1 |
20070074659 | Wahlstrom | Apr 2007 | A1 |
20070175875 | Uckelmann et al. | Aug 2007 | A1 |
20070179655 | Farnworth | Aug 2007 | A1 |
20070182289 | Kigawa et al. | Aug 2007 | A1 |
20070298182 | Perret et al. | Dec 2007 | A1 |
20080236738 | Lo et al. | Oct 2008 | A1 |
20090017219 | Paasche et al. | Jan 2009 | A1 |
20090152771 | Philippi et al. | Jun 2009 | A1 |
20090206056 | Xu et al. | Aug 2009 | A1 |
20100007062 | Larsson et al. | Jan 2010 | A1 |
20100260410 | Taminger et al. | Oct 2010 | A1 |
20100305743 | Larsson | Dec 2010 | A1 |
20100310404 | Ackelid | Dec 2010 | A1 |
20100316856 | Currie et al. | Dec 2010 | A1 |
20110061591 | Stecker | Mar 2011 | A1 |
20110114839 | Stecker et al. | May 2011 | A1 |
20110133367 | Weidinger et al. | Jun 2011 | A1 |
20110240607 | Stecker et al. | Oct 2011 | A1 |
20110241575 | Caiafa et al. | Oct 2011 | A1 |
20110293770 | Ackelid et al. | Dec 2011 | A1 |
20110293771 | Oberhofer et al. | Dec 2011 | A1 |
20110309554 | Liska et al. | Dec 2011 | A1 |
20110316178 | Uckelmann | Dec 2011 | A1 |
20120100031 | Ljungblad | Apr 2012 | A1 |
20120164322 | Teulet et al. | Jun 2012 | A1 |
20120183701 | Pilz et al. | Jul 2012 | A1 |
20120193530 | Parker et al. | Aug 2012 | A1 |
20120211155 | Wehning et al. | Aug 2012 | A1 |
20120223059 | Ackelid | Sep 2012 | A1 |
20120225210 | Fruth | Sep 2012 | A1 |
20120237745 | Dierkes et al. | Sep 2012 | A1 |
20120266815 | Brunermer | Oct 2012 | A1 |
20130055568 | Dusel et al. | Mar 2013 | A1 |
20130162134 | Mattausch et al. | Jun 2013 | A1 |
20130186514 | Zhuang et al. | Jul 2013 | A1 |
20130216959 | Tanaka et al. | Aug 2013 | A1 |
20130233846 | Jakimov et al. | Sep 2013 | A1 |
20130264750 | Hofacker et al. | Oct 2013 | A1 |
20130270750 | Green | Oct 2013 | A1 |
20130278920 | Loewgren | Oct 2013 | A1 |
20130300286 | Ljungblad et al. | Nov 2013 | A1 |
20130343947 | Satzger et al. | Dec 2013 | A1 |
20140175708 | Echigo et al. | Jun 2014 | A1 |
20140271964 | Roberts, IV et al. | Sep 2014 | A1 |
20140301884 | Hellestam et al. | Oct 2014 | A1 |
20140308153 | Ljungblad | Oct 2014 | A1 |
20140314609 | Ljungblad et al. | Oct 2014 | A1 |
20140314964 | Ackelid | Oct 2014 | A1 |
20140348691 | Ljungblad et al. | Nov 2014 | A1 |
20140363327 | Holcomb | Dec 2014 | A1 |
20140367367 | Wood et al. | Dec 2014 | A1 |
20150004045 | Ljungblad | Jan 2015 | A1 |
20150050463 | Nakano et al. | Feb 2015 | A1 |
20150071809 | Nordkvist et al. | Mar 2015 | A1 |
20150086409 | Hellestam | Mar 2015 | A1 |
20150088295 | Hellestam | Mar 2015 | A1 |
20150130118 | Cheng et al. | May 2015 | A1 |
20150139849 | Pialot, Jr. et al. | May 2015 | A1 |
20150151490 | Jonasson et al. | Jun 2015 | A1 |
20150165524 | Ljungblad et al. | Jun 2015 | A1 |
20150165525 | Jonasson | Jun 2015 | A1 |
20150174658 | Ljungblad | Jun 2015 | A1 |
20150174695 | Elfstroem et al. | Jun 2015 | A1 |
20150251249 | Fager | Sep 2015 | A1 |
20150273622 | Manabe | Oct 2015 | A1 |
20150283610 | Ljungblad et al. | Oct 2015 | A1 |
20150283613 | Backlund et al. | Oct 2015 | A1 |
20150290710 | Ackelid | Oct 2015 | A1 |
20150306819 | Ljungblad | Oct 2015 | A1 |
20160052056 | Fager | Feb 2016 | A1 |
20160052079 | Ackelid | Feb 2016 | A1 |
20160054115 | Snis | Feb 2016 | A1 |
20160054121 | Snis | Feb 2016 | A1 |
20160054347 | Snis | Feb 2016 | A1 |
20160059314 | Ljungblad et al. | Mar 2016 | A1 |
20160129501 | Loewgren et al. | May 2016 | A1 |
20160167160 | Hellestam | Jun 2016 | A1 |
20160167303 | Petelet | Jun 2016 | A1 |
20160202042 | Snis | Jul 2016 | A1 |
20160202043 | Snis | Jul 2016 | A1 |
20160211116 | Lock | Jul 2016 | A1 |
20160236279 | Ashton et al. | Aug 2016 | A1 |
20160279735 | Hellestam | Sep 2016 | A1 |
20160282848 | Hellestam | Sep 2016 | A1 |
20160303687 | Ljungblad | Oct 2016 | A1 |
20160307731 | Lock | Oct 2016 | A1 |
20160311021 | Elfstroem et al. | Oct 2016 | A1 |
20170080494 | Ackelid | Mar 2017 | A1 |
20170087661 | Backlund et al. | Mar 2017 | A1 |
20170106443 | Karlsson | Apr 2017 | A1 |
20170106570 | Karlsson | Apr 2017 | A1 |
20170136541 | Fager | May 2017 | A1 |
20170136542 | Nordkvist et al. | May 2017 | A1 |
20170173691 | Jonasson | Jun 2017 | A1 |
20170189964 | Backlund et al. | Jul 2017 | A1 |
20170227417 | Snis | Aug 2017 | A1 |
20170227418 | Snis | Aug 2017 | A1 |
20170246684 | Hellestam | Aug 2017 | A1 |
20170246685 | Hellestam | Aug 2017 | A1 |
20170259338 | Ackelid | Sep 2017 | A1 |
20170282248 | Ljungblad et al. | Oct 2017 | A1 |
20170294288 | Lock | Oct 2017 | A1 |
20170341141 | Ackelid | Nov 2017 | A1 |
20170341142 | Ackelid | Nov 2017 | A1 |
20170348791 | Ekberg | Dec 2017 | A1 |
20170348792 | Fager | Dec 2017 | A1 |
20180009033 | Fager | Jan 2018 | A1 |
20180154444 | Jonasson | Jun 2018 | A1 |
Number | Date | Country |
---|---|---|
2860188 | Jun 2006 | CA |
101607311 | Dec 2009 | CN |
101635210 | Jan 2010 | CN |
201693176 | Jan 2011 | CN |
101607311 | Sep 2011 | CN |
203509463 | Apr 2014 | CN |
19952998 | May 2001 | DE |
20305843 | Jul 2003 | DE |
10235434 | Feb 2004 | DE |
102005014483 | Oct 2006 | DE |
202008005417 | Aug 2008 | DE |
102007018601 | Oct 2008 | DE |
102007029052 | Jan 2009 | DE |
102008012064 | Sep 2009 | DE |
102010041284 | Mar 2012 | DE |
102011105045 | Jun 2012 | DE |
102013210242 | Dec 2014 | DE |
0289116 | Nov 1988 | EP |
0322257 | Jun 1989 | EP |
0688262 | Dec 1995 | EP |
1358994 | Nov 2003 | EP |
1418013 | May 2004 | EP |
1466718 | Oct 2004 | EP |
1486318 | Dec 2004 | EP |
1669143 | Jun 2006 | EP |
1683593 | Jul 2006 | EP |
1721725 | Nov 2006 | EP |
1752240 | Feb 2007 | EP |
1952932 | Aug 2008 | EP |
2011631 | Jan 2009 | EP |
2119530 | Nov 2009 | EP |
2281677 | Feb 2011 | EP |
2289652 | Mar 2011 | EP |
2292357 | Mar 2011 | EP |
2832474 | Feb 2015 | EP |
2980380 | Mar 2013 | FR |
H05-171423 | Jul 1993 | JP |
2003241394 | Aug 2003 | JP |
2003245981 | Sep 2003 | JP |
2009006509 | Jan 2009 | JP |
524467 | Aug 2004 | SE |
WO 199308928 | May 1993 | WO |
WO 1996012607 | May 1996 | WO |
WO 199737523 | Oct 1997 | WO |
WO 2001081031 | Nov 2001 | WO |
WO 200185386 | Nov 2001 | WO |
WO 2002008653 | Jan 2002 | WO |
WO 2004007124 | Jan 2004 | WO |
WO 2004043680 | May 2004 | WO |
WO 2004054743 | Jul 2004 | WO |
WO 2004056511 | Jul 2004 | WO |
WO 2004106041 | Dec 2004 | WO |
WO 2004108398 | Dec 2004 | WO |
WO 2006091097 | Aug 2006 | WO |
WO 2006121374 | Nov 2006 | WO |
WO 2007112808 | Oct 2007 | WO |
WO 2007147221 | Dec 2007 | WO |
WO 2008013483 | Jan 2008 | WO |
WO 2008057844 | May 2008 | WO |
WO 2008074287 | Jun 2008 | WO |
WO 2008125497 | Oct 2008 | WO |
WO 2008147306 | Dec 2008 | WO |
WO 2009000360 | Dec 2008 | WO |
WO 2009072935 | Jun 2009 | WO |
WO 2009084991 | Jul 2009 | WO |
WO 2010095987 | Aug 2010 | WO |
WO 2010125371 | Nov 2010 | WO |
WO 2011008143 | Jan 2011 | WO |
WO 2011011818 | Feb 2011 | WO |
WO 2011030017 | Mar 2011 | WO |
WO 2011060312 | May 2011 | WO |
WO 2012102655 | Aug 2012 | WO |
WO 2013092997 | Jun 2013 | WO |
WO 2013098050 | Jul 2013 | WO |
WO 2013098135 | Jul 2013 | WO |
WO 2013159811 | Oct 2013 | WO |
WO 2013167194 | Nov 2013 | WO |
WO 2013178825 | Dec 2013 | WO |
WO 2014071968 | May 2014 | WO |
WO 2014092651 | Jun 2014 | WO |
WO 2014095200 | Jun 2014 | WO |
WO 2014095208 | Jun 2014 | WO |
WO 2014195068 | Dec 2014 | WO |
WO 2015032590 | Mar 2015 | WO |
WO 2015091813 | Jun 2015 | WO |
WO 2015120168 | Aug 2015 | WO |
WO 2015142492 | Sep 2015 | WO |
Entry |
---|
United States Patent and Trademark Office, Notice of Allowability for U.S. Appl. No. 14/350,767, dated Dec. 18, 2018, 3 pages, U.S.A. |
Cheah, Chi-Mun, et al., “Automatic Algorithm for Generating Complex Polyhedral Scaffold Structure for Tissue Engineering”, Tissue Engineering, 2004, pp. 595-610, vol. 10, No. 3/4, XP002691483. |
European Search Report dated Feb. 16, 2012, for corresponding Application No. EP07852089.7. |
Gibson, D.W., et al., “Additive Manufacturing Technologies: Rapid Prototyping to Direct Digital Manufacturing”, 2010, pp. 126-129, Springer, New York. |
Guibas, Leonidas J., et al., “Randomized Incremental Construction of Delaunay and Voronoi Diagrams”, Algorithmica, Jun. 1992, pp. 381-413, vol. 7, Issue 1-6, Springer-Verlag, New York. |
International Preliminary Examining Authority (IPEA), Second Written Opinion for International Application No. PCT/EP2012/076025, dated Dec. 4, 2013, 4 pages European Patent Office, Germany. |
International Preliminary Examining Authority, International Preliminary Report on Patentability for International Application No. PCT/EP2012/074383, including Applicant's Sep. 6, 2013 Reply to ISA's Feb. 27, 2013 Written Opinion, dated Jan. 20, 2014, 16 pages, European Patent Office, The Netherlands. |
International Preliminary Examining Authority, International Preliminary Report on Patentability for International Application No. PCT/EP2012/076025, including Applicant's Sep. 10, 2013 Response to the ISA's May 17, 2013 Written Opinion and Applicant's Jan. 14, 2014 Response to the IPEA's Second Written Opinion, dated Apr. 4, 2014, 15 pages, European Patent Office, Germany. |
International Preliminary Report on Patentability, dated Nov. 27, 2009, of corresponding international application No. PCT/SE2007/001084. |
International Search Report dated Apr. 9, 2010 for Application No. PCT/SE2009/050901. |
International Search Report dated Sep. 17, 2008 for Application No. PCT/SE2008/000007. |
International Search Report dated Sep. 2, 2008 of corresponding international application No. PCT/SE2007/001084. |
International Searching Authority (ISA), International Search Report and Written Opinion for International Application No. PCT/EP2012/076025, dated May 17, 2013, 11 pages, European Patent Office, The Netherlands. |
International Searching Authority, International Search Report and Written Opinion for International Application No. PCT/EP2012/074383, dated Feb. 27, 2013, 10 pages, European Patent Office, The Netherlands. |
International Searching Authority, International Search Report for International Application No. PCT/EP2012/058733, Mar. 5, 2013, 4 pages, European Patent Office, The Netherlands. |
International Searching Authority, International Search Report for International Application No. PCT/SE2011/050093, dated Oct. 20, 2011, 5 pages, The Swedish Patent and Registration Office, Sweden. |
Klassen, Alexander, et al., “Modelling of Electron Beam Absorption in Complex Geometries”, Journal of Physics D: Applied Physics, Jan. 15, 2014, 12 pages, vol. 47, No. 6, Institute of Physics Publishing Ltd., Great Britain. |
Motojima, Seiji, et al., “Chemical Vapor Growth of LaB6 Whiskers and Crystals Having a Sharp Tip”, Journal of Crystal Growth, vol. 44, No. 1, Aug. 1, 1978 (Aug. 1, 1978), pp. 106-109. |
Office Action dated Feb. 14, 2012 for U.S. Appl. No. 12/745,081. |
Office Action dated Nov. 8, 2011, U.S. Appl. No. 12/745,081. |
United States Patent and Trademark Office, Final Office Action for U.S. Appl. No. 12/745,081, dated Jun. 21, 2012, 6 pages, USA. |
United States Patent and Trademark Office, Notice of Allowance and Fee(s) Due for U.S. Appl. No. 13/144,451, dated Sep. 25, 2012, 16 pages, USA. |
United States Patent and Trademark Office, Office Action for U.S. Appl. No. 12/810,602, dated Sep. 11, 2014, 7 pages, USA. |
United States Patent and Trademark Office, Office Action for U.S. Appl. No. 12/810,602, dated Sep. 10, 2012, 13 pages, USA. |
United States Patent and Trademark Office, Office Action for U.S. Appl. No. 12/810,602, dated Dec. 20, 2012, 8 pages, USA. |
United States Patent and Trademark Office, Office Action for U.S. Appl. No. 14/350,767, dated Nov. 24, 2014, USA. |
United States Patent and Trademark Office, Office Action for U.S. Appl. No. 14/350,767, dated Feb. 23, 2015, USA. |
United States Patent and Trademark Office, Office Action for U.S. Appl. No. 14/350,767, dated May 5, 2016, USA. |
United States Patent and Trademark Office, Office Action for U.S. Appl. No. 14/350,767, dated Sep. 2, 2016, USA. |
United States Patent and Trademark Office, Office Action for U.S. Appl. No. 14/350,767, dated Sep. 7, 2017, USA. |
United States Patent and Trademark Office, Office Action for U.S. Appl. No. 14/350,767, dated Jan. 12, 2018, USA. |
United States Patent and Trademark Office, Office Action for U.S. Appl. No. 14/350,767, dated Aug. 27, 2018, USA. |
United States Patent and Trademark Office, Notice of Allowance for U.S. Appl. No. 14/350,767, dated Oct. 17, 2018, USA. |
United States Patent and Trademark Office, Corrected Notice of Allowability for U.S. Appl. No. 14/350,767, dated Dec. 18, 2018, USA. |
Weigel, TH. , et al., “Design and Preparation of Polymeric Scaffolds for Tissue Engineering,” Expert Rev. Med. Devices, 2006, pp. 835-851, vol. 3, No. 6, XP002691485. |
Yang, et al., “The Design of Scaffolds for Use in Tissue Engineering, Part II, Rapid Prototyping Techniques”, Tissue Engineering, 2002, pp. 1-11, vol. 8, No. 1, XP002691484. |
Number | Date | Country | |
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20190060996 A1 | Feb 2019 | US |
Number | Date | Country | |
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61580775 | Dec 2011 | US |
Number | Date | Country | |
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Parent | 14350767 | US | |
Child | 16166805 | US |