Method and apparatus for penetrating tissue

Description

BACKGROUND OF THE INVENTION

Lancing devices are known in the medical health-care products industry for piercing the skin to produce blood for analysis. Typically, a drop of blood for this type of analysis is obtained by making a small incision in the fingertip, creating a small wound, which generates a small blood droplet on the surface of the skin.

Early methods of lancing included piercing or slicing the skin with a needle or razor. Current methods utilize lancing devices that contain a multitude of spring, cam and mass actuators to drive the lancet. These include cantilever springs, diaphragms, coil springs, as well as gravity plumbs used to drive the lancet. The device may be held against the skin and mechanically triggered to ballistically launch the lancet. Unfortunately, the pain associated with each lancing event using known technology discourages patients from testing. In addition to vibratory stimulation of the skin as the driver impacts the end of a launcher stop, known spring based devices have the possibility of harmonically oscillating against the patient tissue, causing multiple strikes due to recoil. This recoil and multiple strikes of the lancet against the patient is one major impediment to patient compliance with a structured glucose monitoring regime.

Another impediment to patient compliance is the lack of spontaneous blood flow generated by known lancing technology. In addition to the pain as discussed above, a patient may need more than one lancing event to obtain a blood sample since spontaneous blood generation is unreliable using known lancing technology. Thus the pain is multiplied by the number of tries it takes to successfully generate spontaneous blood flow. Different skin thickness may yield different results in terms of pain perception, blood yield and success rate of obtaining blood between different users of the lancing device. Known devices poorly account for these skin thickness variations.

A still further impediment to improved compliance with glucose monitoring are the many steps and hassle associated with each lancing event. Many diabetic patients that are insulin dependent may need to self-test for blood glucose levels five to six times daily. The large number of steps required in traditional methods of glucose testing, ranging from lancing, to milking of blood, applying blood to the test strip, and getting the measurements from the test strip, discourages many diabetic patients from testing their blood glucose levels as often as recommended. Older patients and those with deteriorating motor skills encounter difficulty loading lancets into launcher devices, transferring blood onto a test strip, or inserting thin test strips into slots on glucose measurement meters. Additionally, the wound channel left on the patient by known systems may also be of a size that discourages those who are active with their hands or who are worried about healing of those wound channels from testing their glucose levels.

SUMMARY OF THE INVENTION

Accordingly, an object of the present invention is to provide improved tissue penetrating systems, and their methods of use.

Another object of the present invention is to provide tissue penetrating systems, and their methods of use, that provide reduced pain when penetrating a target tissue.

Yet another object of the present invention is to provide tissue penetrating systems, and their methods of use, that provide controlled depth of penetration.

Still a further object of the present invention is to provide tissue penetrating systems, and their methods of use, that provide controlled velocities into and out of target tissue.

A further object of the present invention is to provide tissue penetrating systems, and their methods of use, that provide stimulation to a target tissue.

Another object of the present invention is to provide tissue penetrating systems, and their methods of use, that apply a pressure to a target tissue.

Yet another object of the present invention is to provide tissue penetrating systems, and their methods of use, with penetrating members that remain in sterile environments prior to launch.

Still another object of the present invention is to provide tissue penetrating systems, and their methods of use, with penetrating members that remain in sterile environments prior to launch, and the penetrating members are not used to breach the sterile environment.

A further object of the present invention is to provide improved tissue penetrating systems, and their methods of use, that have user interfaces.

Another object of the present invention is to provide improved tissue penetrating systems, and their methods of use, that have human interfaces.

Yet another object of the present invention is to provide tissue penetrating systems, and their methods of use, that have low volume sample chambers.

Still another object of the present invention is to provide tissue penetrating systems, and their methods of use, that have sample chambers with volumes that do not exceed 1 μL.

Another object of the present invention is to provide tissue penetrating systems, and their methods of use, that have multiple penetrating members housed in a cartridge.

These and other objects of the present invention are achieved in a body fluid sampling system for use on a tissue site that includes a drive force generator and a penetrating member operatively coupled to the force generator. The force generator moves the member along a path out of a housing with a penetrating member exit, into the tissue site, stops in the tissue site, and withdraws out of the tissue site. The drive force generator is configured to be controlled to follow a predetermined velocity trajectory into the tissue and out of the tissue. A tissue stabilizing member is associated with the device and at least partially surrounds an impact location of the penetrating member on the tissue site.

In another embodiment of the present invention, a body fluid sampling system for use on a tissue site includes a housing and an electrically powered drive force generator. A penetrating member is operatively coupled to the force generator. The force generator moves the member along a path out of the housing with a penetrating member exit, into the tissue site, stops in the tissue site, and withdraws out of the tissue site. A skin stabilizing member is associated with the housing and positioned to at least partially surround an impact location of the penetrating member on the tissue site.

In another embodiment of the present invention, a body fluid sampling system for use on a tissue site includes a drive force generator and a penetrating member operatively coupled to the force generator. The force generator moves the member along a path out of a housing with a penetrating member exit, into the tissue site, stops in the tissue site, and withdraws out of the tissue site. A position sensor is used to determine a position of the penetrating member during actuation. A skin stabilizing member is associated with the housing and positioned to at least partially surround an impact location of the penetrating member on the tissue site.

In another embodiment of the present invention, a body fluid sampling system for use on a tissue site includes a drive force generator and a penetrating member operatively coupled to the force generator. The force generator moves the member along a path out of a housing with a penetrating member exit, into the tissue site, stops in the tissue site, and withdraws out of the tissue site. The penetrating member is an elongate member without a molded attachment. A coupler, on the force generator, is configured to engage at least a portion of the elongate portion of the penetrating member and drive the member along a path into a tissue site and withdrawn from a tissue site. A skin stabilizing member is associated with the housing and positioned to at least partially surround an impact location of the penetrating member on the tissue site

In another embodiment of the present invention, a body fluid sampling system for use on a tissue site includes a voice coil drive force generator and a plurality of modules, each containing a penetrating member. Each of the modules is coupled together to define a flexible array. A transport device moves each of the modules into a launch position to operatively couple the penetrating member to the force generator. A skin stabilizing member is associated with the housing and positioned to at least partially surround an impact location of the penetrating member on the tissue site.

In another embodiment of the present invention, a body fluid sampling system for use on a tissue site includes a drive force generator. A penetrating member is provided that has an elongate portion without a molded attachment and is operatively coupled to the force generator. A sterility enclosure covers at least a tip of the penetrating member. The sterility enclosure is removed from the penetrating member prior to actuation of the member and positioned so that the penetrating member will not contact the enclosure during actuation. A skin stabilizing member is associated with the housing and positioned to at least partially surround an impact location of the penetrating member on the tissue site.

In another embodiment of the present invention, a body fluid sampling system for use on a tissue site includes a drive force generator. A penetrating member has an elongate portion without a molded attachment and is operatively coupled to the force generator. A sterility enclosure creates a sterile environment around at least a tip of the penetrating member. The penetrating member breaches the sterile environment during actuation. A skin stabilizing member is associated with the housing and positioned to at least partially surround an impact location of the penetrating member on the tissue site.

In another embodiment of the present invention, a body fluid sampling system for use on a tissue site includes a drive force generator. A penetrating member is operatively coupled to the force generator. The force generator moves the member along a path out of a housing with a penetrating member exit, into the tissue site, stops in the tissue site, and withdraws out of the tissue site. An analyte detection member is positioned to receive fluid from a wound created by the penetrating member. The detection member is configured to determine a concentration of an analyte in the fluid using a sample of less than 1 μL of the fluid. A skin stabilizing member is associated with the housing and positioned to at least partially surround an impact location of the penetrating member on the tissue site.

In another embodiment of the present invention, a body fluid sampling system for use on a tissue site includes an electrically powered drive force generator. A penetrating member is operatively coupled to the force generator. The force generator moves the member along a path out of a housing with a penetrating member exit, into the tissue site, stops in the tissue site, and withdraws out of the tissue site. A vacuum source is associated with the device for creating a lower atmosphere environment to draw fluid from a wound created by the penetrating member.

In another embodiment of the present invention, a body fluid sampling system for use on a tissue site includes an electrically powered drive force generator. A penetrating member is operatively coupled to the force generator. The force generator moves the member along a path out of a housing with a penetrating member exit, into the tissue site, stops in the tissue site, and withdraws out of the tissue site. A movable capillary tube is advancable between a first position and a second position.

A further understanding of the nature and advantages of the invention will become apparent by reference to the remaining portions of the specification and drawings.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 illustrates an embodiment of a controllable force driver in the form of a cylindrical electric penetrating member driver using a coiled solenoid-type configuration.

FIG. 2A illustrates a displacement over time profile of a penetrating member driven by a harmonic spring/mass system.

FIG. 2B illustrates the velocity over time profile of a penetrating member driver by a harmonic spring/mass system.

FIG. 2C illustrates a displacement over time profile of an embodiment of a controllable force driver.

FIG. 2D illustrates a velocity over time profile of an embodiment of a controllable force driver.

FIG. 3 is a diagrammatic view illustrating a controlled feed-back loop.

FIG. 4 is a perspective view of a tissue penetration device having features of the invention.

FIG. 5 is an elevation view in partial longitudinal section of the tissue penetration device of FIG. 4.

FIGS. 6A-6C show a flowchart illustrating a penetrating member control method.

FIG. 7 is a diagrammatic view of a patient's finger and a penetrating member tip moving toward the skin of the finger.

FIG. 8 is a diagrammatic view of a patient's finger and the penetrating member tip making contact with the skin of a patient's finger.

FIG. 9 is a diagrammatic view of the penetrating member tip depressing the skin of a patient's finger.

FIG. 10 is a diagrammatic view of the penetrating member tip further depressing the skin of a patient's finger.

FIG. 11 is a diagrammatic view of the penetrating member tip penetrating the skin of a patient's finger.

FIG. 12 is a diagrammatic view of the penetrating member tip penetrating the skin of a patient's finger to a desired depth.

FIG. 13 is a diagrammatic view of the penetrating member tip withdrawing from the skin of a patient's finger.

FIGS. 14-18 illustrate a method of tissue penetration that may measure elastic recoil of the skin.

FIG. 19 is a perspective view in partial section of a tissue penetration sampling device with a cartridge of sampling modules.

FIG. 20 is a perspective view of a sampling module cartridge with the sampling modules arranged in a ring configuration.

FIG. 21 illustrate an embodiment of a cartridge for use in sampling having a sampling cartridge body and a penetrating member cartridge body.

FIG. 22A shows a device for use on a tissue site having a plurality of penetrating members.

FIG. 22B shows rear view of a device for use on a tissue site having a plurality of penetrating members.

FIG. 22C shows a schematic of a device for use on a tissue site with a feedback loop and optionally a damper.

FIG. 23A shows an embodiment of a device with a user interface.

FIG. 23B shows an outer view of a device with a user interface.

FIG. 24 is a cut away view of a system for sampling body fluid.

FIG. 25 is an exploded view of a cartridge for use with a system for sampling body fluid.

FIG. 26 is an exploded view of a cartridge having multiple penetrating members for use with a system for sampling body fluid.

FIGS. 27-28 show cartridges for use with a system for sampling body fluid.

FIG. 29 shows a cutaway view of another embodiment of a system for sampling body fluid.

FIG. 30 shows the density associated with a cartridge according to the present invention.

FIG. 31 shows a cutaway view of another embodiment of a system for sampling body fluid.

FIG. 32 is a cut away view of a cartridge according to the present invention.

FIGS. 33-34 show views of a body sampling system using multiple cartridges.

FIG. 35 shows an embodiment of the present invention with a tissue stabilizing member.

FIG. 36 shows a cartridge according to the present invention with a tissue stabilizing member.

FIG. 37 shows a system according to the present invention with a moveable cartridge.

DESCRIPTION OF THE SPECIFIC EMBODIMENTS

The present invention provides a solution for body fluid sampling. Specifically, some embodiments of the present invention provides a penetrating member device for consistently creating a wound with spontaneous body fluid flow from a patient. The invention may be a multiple penetrating member device with an optional high density design. It may use penetrating members of smaller size than known penetrating members. The device may be used for multiple lancing events without having to remove a disposable from the device or for the user to handle sharps. The invention may provide improved sensing capabilities. At least some of these and other objectives described herein will be met by embodiments of the present invention.

It is to be understood that both the foregoing general description and the following detailed description are exemplary and explanatory only and are not restrictive of the invention, as claimed. It should be noted that, as used in the specification and the appended claims, the singular forms “a”, “an” and “the” include plural referents unless the context clearly dictates otherwise. Thus, for example, reference to “a material” may include mixtures of materials, reference to “a chamber” may include multiple chambers, and the like. References cited herein are hereby incorporated by reference in their entirety, except to the extent that they conflict with teachings explicitly set forth in this specification.

In this specification and in the claims which follow, reference will be made to a number of terms which shall be defined to have the following meanings:

“Optional” or “optionally” means that the subsequently described circumstance may or may not occur, so that the description includes instances where the circumstance occurs and instances where it does not. For example, if a device optionally contains a feature for analyzing a blood sample, this means that the analysis feature may or may not be present, and, thus, the description includes structures wherein a device possesses the analysis feature and structures wherein the analysis feature is not present.

“Analyte detecting member” refers to any use, singly or in combination, of chemical test reagents and methods, electrical test circuits and methods, physical test components and methods, optical test components and methods, and biological test reagents and methods to yield information about a blood sample. Such methods are well known in the art and may be based on teachings of, e.g. Tietz Textbook of Clinical Chemistry, 3d Ed., Sec. V, pp. 776-78 (Burtis & Ashwood, Eds., W.B. Saunders Company, Philadelphia, 1999); U.S. Pat. No. 5,997,817 to Chrismore et al. (Dec. 7, 1999); U.S. Pat. No. 5,059,394 to Phillips et al. (Oct. 22, 1991); U.S. Pat. No. 5,001,054 to Wagner et al. (Mar. 19, 1991); and U.S. Pat. No. 4,392,933 to Nakamura et al. (Jul. 12, 1983), the teachings of which are hereby incorporated by reference, as well as others. Analyte detecting member may include tests in the sample test chamber that test electrochemical properties of the blood, or they may include optical means for sensing optical properties of the blood (e.g. oxygen saturation level), or they may include biochemical reagents (e.g. antibodies) to sense properties (e.g. presence of antigens) of the blood. The analyte detecting member may comprise biosensing or reagent material that will react with an analyte in blood (e.g. glucose) or other body fluid so that an appropriate signal correlating with the presence of the analyte is generated and can be read by the reader apparatus. By way of example and not limitation, analyte detecting member may “associated with”, “mounted within”, or “coupled to” a chamber or other structure when the analyte detecting member participates in the function of providing an appropriate signal about the blood sample to the reader device. Analyte detecting member may also include nanowire analyte detecting members as described herein. Analyte detecting member may use potentiometric, coulometric, or other method useful for detection of analyte levels.

The present invention may be used with a variety of different penetrating member drivers. It is contemplated that these penetrating member drivers may be spring based, solenoid based, magnetic driver based, nanomuscle based, or based on any other mechanism useful in moving a penetrating member along a path into tissue. It should be noted that the present invention is not limited by the type of driver used with the penetrating member feed mechanism. One suitable penetrating member driver for use with the present invention is shown in FIG. 1. This is an embodiment of a solenoid type electromagnetic driver that is capable of driving an iron core or slug mounted to the penetrating member assembly using a direct current (DC) power supply. The electromagnetic driver includes a driver coil pack that is divided into three separate coils along the path of the penetrating member, two end coils and a middle coil. Direct current is alternated to the coils to advance and retract the penetrating member. Although the driver coil pack is shown with three coils, any suitable number of coils may be used, for example, 4, 5, 6, 7 or more coils may be used.

Referring to the embodiment of FIG. 1, the stationary iron housing 10 may contain the driver coil pack with a first coil 12 flanked by iron spacers 14 which concentrate the magnetic flux at the inner diameter creating magnetic poles. The inner insulating housing 16 isolates the penetrating member 18 and iron core 20 from the coils and provides a smooth, low friction guide surface. The penetrating member guide 22 further centers the penetrating member 18 and iron core 20. The penetrating member 18 is protracted and retracted by alternating the current between the first coil 12, the middle coil, and the third coil to attract the iron core 20. Reversing the coil sequence and attracting the core and penetrating member back into the housing retracts the penetrating member. The penetrating member guide 22 also serves as a stop for the iron core 20 mounted to the penetrating member 18.

As discussed above, tissue penetration devices which employ spring or cam driving methods have a symmetrical or nearly symmetrical actuation displacement and velocity profiles on the advancement and retraction of the penetrating member as shown in FIGS. 2 and 3. In most of the available lancet devices, once the launch is initiated, the stored energy determines the velocity profile until the energy is dissipated. Controlling impact, retraction velocity, and dwell time of the penetrating member within the tissue can be useful in order to achieve a high success rate while accommodating variations in skin properties and minimize pain. Advantages can be achieved by taking into account of the fact that tissue dwell time is related to the amount of skin deformation as the penetrating member tries to puncture the surface of the skin and variance in skin deformation from patient to patient based on skin hydration.

In this embodiment, the ability to control velocity and depth of penetration may be achieved by use of a controllable force driver where feedback is an integral part of driver control. Such drivers can control either metal or polymeric penetrating members or any other type of tissue penetration element. The dynamic control of such a driver is illustrated in FIG. 2C which illustrates an embodiment of a controlled displacement profile and FIG. 2D which illustrates an embodiment of a the controlled velocity profile. These are compared to FIGS. 2A and 2B, which illustrate embodiments of displacement and velocity profiles, respectively, of a harmonic spring/mass powered driver. Reduced pain can be achieved by using impact velocities of greater than about 2 m/s entry of a tissue penetrating element, such as a lancet, into tissue. Other suitable embodiments of the penetrating member driver are described in commonly assigned, copending U.S. patent application Ser. No. 10/127,395, filed Apr. 19, 2002 and previously incorporated herein.

FIG. 3 illustrates the operation of a feedback loop using a processor 60. The processor 60 stores profiles 62 in non-volatile memory. A user inputs information 64 about the desired circumstances or parameters for a lancing event. The processor 60 selects a velocity vs. position profile 62 from a set of alternative driver profiles that have been preprogrammed in the processor 60 based on typical or desired tissue penetration device performance determined through testing at the factory or as programmed in by the operator. The processor 60 may customize by either scaling or modifying the profile based on additional user input information 64. Once the processor has chosen and customized the profile, the processor 60 is ready to modulate the power from the power supply 66 to the penetrating member driver 68 through an amplifier 70. The processor 60 may measure the location of the penetrating member 72 using a position sensing mechanism 74 through an analog to digital converter 76 linear encoder or other such transducer. Examples of position sensing mechanisms have been described in the embodiments above and may be found in the specification for commonly assigned, copending U.S. patent application Ser. No. 10/127,395, filed Apr. 19, 2002 and previously incorporated herein. The processor 60 calculates the movement of the penetrating member by comparing the actual profile of the penetrating member to the predetermined velocity vs. position profile. The processor 60 modulates the power to the penetrating member driver 68 through a signal generator 78, which may control the amplifier 70 so that the actual velocity profile of the penetrating member matches and does not exceed the predetermined velocity vs. position profile by more than a preset error limit. The error limit is the accuracy in the control of the penetrating member.

After the lancing event, the processor 60 can allow the user to rank the results of the lancing event. The processor 60 stores these results and constructs a database 80 for the individual user. Using the database 79, the processor 60 calculates the profile traits such as degree of painlessness, success rate, and blood volume for various profiles 62 depending on user input information 64 to optimize the profile to the individual user for subsequent lancing cycles. These profile traits depend on the characteristic phases of penetrating member advancement and retraction. The processor 60 uses these calculations to optimize profiles 62 for each user. In addition to user input information 64, an internal clock allows storage in the database 79 of information such as the time of day to generate a time stamp for the lancing event and the time between lancing events to anticipate the user's diurnal needs. The database stores information and statistics for each user and each profile that particular user uses.

In addition to varying the profiles, the processor 60 can be used to calculate the appropriate penetrating member diameter and geometry suitable to realize the blood volume required by the user. For example, if the user requires about 1-5 microliter volume of blood, the processor 60 may select a 200 micron diameter penetrating member to achieve these results. For each class of lancet, both diameter and lancet tip geometry, is stored in the processor 60 to correspond with upper and lower limits of attainable blood volume based on the predetermined displacement and velocity profiles.

The lancing device is capable of prompting the user for information at the beginning and the end of the lancing event to more adequately suit the user. The goal is to either change to a different profile or modify an existing profile. Once the profile is set, the force driving the penetrating member is varied during advancement and retraction to follow the profile. The method of lancing using the lancing device comprises selecting a profile, lancing according to the selected profile, determining lancing profile traits for each characteristic phase of the lancing cycle, and optimizing profile traits for subsequent lancing events.

FIG. 4 illustrates an embodiment of a tissue penetration device, more specifically, a lancing device 80 that includes a controllable driver 179 coupled to a tissue penetration element. The lancing device 80 has a proximal end 81 and a distal end 82. At the distal end 82 is the tissue penetration element in the form of a penetrating member 83, which is coupled to an elongate coupler shaft 84 by a drive coupler 85. The elongate coupler shaft 84 has a proximal end 86 and a distal end 87. A driver coil pack 88 is disposed about the elongate coupler shaft 84 proximal of the penetrating member 83. A position sensor 91 is disposed about a proximal portion 92 of the elongate coupler shaft 84 and an electrical conductor 94 electrically couples a processor 93 to the position sensor 91. The elongate coupler shaft 84 driven by the driver coil pack 88 controlled by the position sensor 91 and processor 93 form the controllable driver, specifically, a controllable electromagnetic driver.

Referring to FIG. 5, the lancing device 80 can be seen in more detail, in partial longitudinal section. The penetrating member 83 has a proximal end 95 and a distal end 96 with a sharpened point at the distal end 96 of the penetrating member 83 and a drive head 98 disposed at the proximal end 95 of the penetrating member 83. A penetrating member shaft 201 is disposed between the drive head 98 and the sharpened point 97. The penetrating member shaft 201 may be comprised of stainless steel, or any other suitable material or alloy and have a transverse dimension of about 0.1 to about 0.4 mm. The penetrating member shaft may have a length of about 3 mm to about 50 mm, specifically, about 15 mm to about 20 mm. The drive head 98 of the penetrating member 83 is an enlarged portion having a transverse dimension greater than a transverse dimension of the penetrating member shaft 201 distal of the drive head 98. This configuration allows the drive head 98 to be mechanically captured by the drive coupler 85. The drive head 98 may have a transverse dimension of about 0.5 to about 2 mm.

A magnetic member 102 is secured to the elongate coupler shaft 84 proximal of the drive coupler 85 on a distal portion 203 of the elongate coupler shaft 84. The magnetic member 102 is a substantially cylindrical piece of magnetic material having an axial lumen 204 extending the length of the magnetic member 102. The magnetic member 102 has an outer transverse dimension that allows the magnetic member 102 to slide easily within an axial lumen 105 of a low friction, possibly lubricious, polymer guide tube 105′ disposed within the driver coil pack 88. The magnetic member 102 may have an outer transverse dimension of about 1.0 to about 5.0 mm, specifically, about 2.3 to about 2.5 mm. The magnetic member 102 may have a length of about 3.0 to about 5.0 mm, specifically, about 4.7 to about 4.9 mm. The magnetic member 102 can be made from a variety of magnetic materials including ferrous metals such as ferrous steel, iron, ferrite, or the like. The magnetic member 102 may be secured to the distal portion 203 of the elongate coupler shaft 84 by a variety of methods including adhesive or epoxy bonding, welding, crimping or any other suitable method.

Proximal of the magnetic member 102, an optical encoder flag 206 is secured to the elongate coupler shaft 84. The optical encoder flag 206 is configured to move within a slot 107 in the position sensor 91. The slot 107 of the position sensor 91 is formed between a first body portion 108 and a second body portion 109 of the position sensor 91. The slot 107 may have separation width of about 1.5 to about 2.0 mm. The optical encoder flag 206 can have a length of about 14 to about 18 mm, a width of about 3 to about 5 mm and a thickness of about 0.04 to about 0.06 mm.

The optical encoder flag 206 interacts with various optical beams generated by LEDs disposed on or in the position sensor body portions 108 and 109 in a predetermined manner. The interaction of the optical beams generated by the LEDs of the position sensor 91 generates a signal that indicates the longitudinal position of the optical flag 206 relative to the position sensor 91 with a substantially high degree of resolution. The resolution of the position sensor 91 may be about 200 to about 400 cycles per inch, specifically, about 350 to about 370 cycles per inch. The position sensor 91 may have a speed response time (position/time resolution) of 0 to about 120,000 Hz, where one dark and light stripe of the flag constitutes one Hertz, or cycle per second. The position of the optical encoder flag 206 relative to the magnetic member 102, driver coil pack 88 and position sensor 91 is such that the optical encoder 91 can provide precise positional information about the penetrating member 83 over the entire length of the penetrating member's power stroke.

An optical encoder that is suitable for the position sensor 91 is a linear optical incremental encoder, model HEDS 9200, manufactured by Agilent Technologies. The model HEDS 9200 may have a length of about 20 to about 30 mm, a width of about 8 to about 12 mm, and a height of about 9 to about 11 mm. Although the position sensor 91 illustrated is a linear optical incremental encoder, other suitable position sensor embodiments could be used, provided they posses the requisite positional resolution and time response. The HEDS 9200 is a two channel device where the channels are 90 degrees out of phase with each other. This results in a resolution of four times the basic cycle of the flag. These quadrature outputs make it possible for the processor to determine the direction of penetrating member travel. Other suitable position sensors include capacitive encoders, analog reflective sensors, such as the reflective position sensor discussed above, and the like.

A coupler shaft guide 111 is disposed towards the proximal end 81 of the lancing device 80. The guide 111 has a guide lumen 112 disposed in the guide 111 to slidingly accept the proximal portion 92 of the elongate coupler shaft 84. The guide 111 keeps the elongate coupler shaft 84 centered horizontally and vertically in the slot 102 of the optical encoder 91.

The driver coil pack 88, position sensor 91 and coupler shaft guide 111 are all secured to a base 113. The base 113 is longitudinally coextensive with the driver coil pack 88, position sensor 91 and coupler shaft guide 111. The base 113 can take the form of a rectangular piece of metal or polymer, or may be a more elaborate housing with recesses, which are configured to accept the various components of the lancing device 80.

As discussed above, the magnetic member 102 is configured to slide within an axial lumen 105 of the driver coil pack 88. The driver coil pack 88 includes a most distal first coil 114, a second coil 115, which is axially disposed between the first coil 114 and a third coil 116, and a proximal-most fourth coil 117. Each of the first coil 114, second coil 115, third coil 116 and fourth coil 117 has an axial lumen. The axial lumens of the first through fourth coils are configured to be coaxial with the axial lumens of the other coils and together form the axial lumen 105 of the driver coil pack 88 as a whole. Axially adjacent each of the coils 114-117 is a magnetic disk or washer 118 that augments completion of the magnetic circuit of the coils 114-117 during a lancing cycle of the device 80. The magnetic washers 118 of the embodiment of FIG. 5 are made of ferrous steel but could be made of any other suitable magnetic material, such as iron or ferrite. The outer shell 89 of the driver coil pack 88 is also made of iron or steel to complete the magnetic path around the coils and between the washers 118. The magnetic washers 118 have an outer diameter commensurate with an outer diameter of the driver coil pack 88 of about 4.0 to about 8.0 mm. The magnetic washers 118 have an axial thickness of about 0.05, to about 0.4 mm, specifically, about 0.15 to about 0.25 mm.

Wrapping or winding an elongate electrical conductor 121 about an axial lumen until a sufficient number of windings have been achieved forms the coils 114-117. The elongate electrical conductor 121 is generally an insulated solid copper wire with a small outer transverse dimension of about 0.06 mm to about 0.88 mm, specifically, about 0.3 mm to about 0.5 mm. In one embodiment, 32 gauge copper wire is used for the coils 114-117. The number of windings for each of the coils 114-117 of the driver pack 88 may vary with the size of the coil, but for some embodiments each coil 114-117 may have about 30 to about 80 turns, specifically, about 50 to about 60 turns. Each coil 114-117 can have an axial length of about 1.0 to about 3.0 mm, specifically, about 1.8 to about 2.0 mm. Each coil 114-117 can have an outer transverse dimension or diameter of about 4.0, to about 2.0 mm, specifically, about 9.0 to about 12.0 mm. The axial lumen 105 can have a transverse dimension of about 1.0 to about 3.0 mm.

It may be advantageous in some driver coil 88 embodiments to replace one or more of the coils with permanent magnets, which produce a magnetic field similar to that of the coils when the coils are activated. In particular, it may be desirable in some embodiments to replace the second coil 115, the third coil 116 or both with permanent magnets. In addition, it may be advantageous to position a permanent magnet at or near the proximal end of the coil driver pack in order to provide fixed magnet zeroing function for the magnetic member (Adams magnetic Products 23A0002 flexible magnet material (800) 747-7543).

A permanent bar magnet 119 is disposed on the proximal end of the driver coil pack 88. As shown in FIG. 5, the bar magnet 119 is arranged so as to have one end disposed adjacent the travel path of the magnetic member 102 and has a polarity configured so as to attract the magnetic member 102 in a centered position with respect to the bar magnet 119. Note that the polymer guide tube 105′ can be configured to extend proximally to insulate the inward radial surface of the bar magnet 119 from an outer surface of the magnetic member 102. This arrangement allows the magnetic member 119 and thus the elongate coupler shaft 84 to be attracted to and held in a zero point or rest position without the consumption of electrical energy from the power supply 125.

Having a fixed zero or start point for the elongate coupler shaft 84 and penetrating member 83 may be useful to properly controlling the depth of penetration of the penetrating member 83 as well as other lancing parameters. This can be because some methods of depth penetration control for a controllable driver measure the acceleration and displacement of the elongate coupler shaft 84 and penetrating member 83 from a known start position. If the distance of the penetrating member tip 96 from the target tissue is known, acceleration and displacement of the penetrating member is known and the start position of the penetrating member is know, the time and position of tissue contact and depth of penetration can be determined by the processor 93.

Any number of configurations for a magnetic bar 119 can be used for the purposes discussed above. In particular, a second permanent bar magnet (not shown) could be added to the proximal end of the driver coil pack 88 with the magnetic fields of the two bar magnets configured to complement each other. In addition, a disc magnet 119′ could be used as illustrated in FIG. 23(a). The disc magnet is shown disposed at the proximal end of the driver coiled pack 88 with a polymer non-magnetic disc disposed between the proximal-most coil 117 and disc magnet and positions disc magnet away from the proximal end of the proximal-most coil 117. The polymer non-magnetic disc spacer is used so that the magnetic member 102 can be centered in a zero or start position slightly proximal of the proximal-most coil 117 of the driver coil pack 88. This allows the magnetic member to be attracted by the proximal-most coil 117 at the initiation of the lancing cycle instead of being passive in the forward drive portion of the lancing cycle.

An inner lumen of the polymer non-magnetic disc can be configured to allow the magnetic member 102 to pass axially there through while an inner lumen of the disc magnet can be configured to allow the elongate coupler shaft 84 to pass through but not large enough for the magnetic member 102 to pass through. This results in the magnetic member 102 being attracted to the disc magnet and coming to rest with the proximal surface of the magnetic member 102 against a distal surface of the disc magnet 119′. This arrangement provides for a positive and repeatable stop for the magnetic member, and hence the penetrating member.

Typically, when the electrical current in the coils 114-117 of the driver coil pack 88 is off, a magnetic member 102 made of soft iron is attracted to the bar magnet 119 or the disc magnet. The magnetic field of the driver coil pack 88 and the bar magnet 119 or the disc magnet, or any other suitable magnet, can be configured such that when the electrical current in the coils 114-117 is turned on, the leakage magnetic field from the coils 114-117 has the same polarity as the bar magnet 119 or the disc magnet. This results in a magnetic force that repels the magnetic member 102 from the bar magnet 119 or disc magnet and attracts the magnetic member 102 to the activated coils 114-117. For this configuration, the bar magnet 119 or the disc magnet thus act to facilitate acceleration of the magnetic member 102 as opposed to working against the acceleration.

Electrical conductors 122 couple the driver coil pack 88 with the processor 93 which can be configured or programmed to control the current flow in the coils 114-117 of the driver coil pack 88 based on position feedback from the position sensor 91, which is coupled to the processor 93 by electrical conductors 94. A power source 125 is electrically coupled to the processor 93 and provides electrical power to operate the processor 93 and power the coil driver pack 88. The power source 125 may be one or more batteries that provide direct current power to the 93 processor.

Referring to FIGS. 29A-29C, a flow diagram is shown that describes the operations performed by the processor 93 in controlling the penetrating member 83 of the lancing device 80 discussed above during an operating cycle. FIGS. 30-36 illustrate the interaction of the penetrating member 83 and skin 133 of the patient's finger 134 during an operation cycle of the penetrating member device 83. The processor 93 operates under control of programming steps that are stored in an associated memory. When the programming steps are executed, the processor 93 performs operations as described herein. Thus, the programming steps implement the functionality of the operations described with respect to the flow diagram of FIG. 29. The processor 93 can receive the programming steps from a program product stored in recordable media, including a direct access program product storage device such as a hard drive or flash ROM, a removable program product storage device such as a floppy disk, or in any other manner known to those of skill in the art. The processor 93 can also download the programming steps through a network connection or serial connection.

In the first operation, represented by the flow diagram box numbered 245 in FIG. 6A, the processor 93 initializes values that it stores in memory relating to control of the penetrating member, such as variables that it uses to keep track of the controllable driver 179 during movement. For example, the processor may set a clock value to zero and a penetrating member position value to zero or to some other initial value. The processor 93 may also cause power to be removed from the coil pack 88 for a period of time, such as for about 10 ms, to allow any residual flux to dissipate from the coils.

In the initialization operation, the processor 93 also causes the penetrating member to assume an initial stationary position. When in the initial stationary position, the penetrating member 83 is typically fully retracted such that the magnetic member 102 is positioned substantially adjacent the fourth coil 117 of the driver coil pack 88, shown in FIG. 5 above. The processor 93 can move the penetrating member 83 to the initial stationary position by pulsing an electrical current to the fourth coil 117 to thereby attract the magnetic member 102 on the penetrating member 83 to the fourth coil 117. Alternatively, the magnetic member can be positioned in the initial stationary position by virtue of a permanent magnet, such as bar magnet 119, disc magnet 119′ or any other suitable magnet as discussed above with regard to the tissue penetration device illustrated in FIGS. 20 and 21.

In the next operation, represented by the flow diagram box numbered 247, the processor 93 energizes one or more of the coils in the coil pack 88. This should cause the penetrating member 83 to begin to move (i.e., achieve a non-zero speed) toward the skin target 133. The processor 93 then determines whether or not the penetrating member is indeed moving. The processor 93 can determine whether the penetrating member 83 is moving by monitoring the position of the penetrating member 83 to determine whether the position changes over time. The processor 93 can monitor the position of the penetrating member 83 by keeping track of the position of the optical encoder flag 106 secured to the elongate coupler shaft 84 wherein the encoder 91 produces a signal coupled to the processor 93 that indicates the spatial position of the penetrating member 83.

If the processor 93 determines (via timeout without motion events) that the penetrating member 83 is not moving, then the process proceeds to where the processor deems that an error condition is present. This means that some error in the system is causing the penetrating member 83 not to move. The error may be mechanical, electrical, or software related. For example, the penetrating member 83 may be stuck in the stationary position because something is impeding its movement.

If the processor 93 determines that the penetrating member 83 is indeed moving (a “Yes” result from the decision box numbered 249), then the process proceeds to the operation represented by the flow diagram box numbered 257. In this operation, the processor 93 causes the penetrating member 83 to continue to accelerate and launch toward the skin target 133, as indicated by the arrow 135 in FIG. 7. The processor 93 can achieve acceleration of the penetrating member 83 by sending an electrical current to an appropriate coil 114-117 such that the coil 114-117 exerts an attractive magnetic launching force on the magnetic member 102 and causes the magnetic member 102 and the penetrating member 83 coupled thereto to move in a desired direction. For example, the processor 93 can cause an electrical current to be sent to the third coil 116 so that the third coil 116 attracts the magnetic member 102 and causes the magnetic member 102 to move from a position adjacent the fourth coil 117 toward the third coil 116. The processor preferably determines which coil 114-117 should be used to attract the magnetic member 102 based on the position of the magnetic member 102 relative to the coils 114-117. In this manner, the processor 93 provides a controlled force to the penetrating member that controls the movement of the penetrating member.

During this operation, the processor 93 periodically or continually monitors the position and/or velocity of the penetrating member 83. In keeping track of the velocity and position of the penetrating member 83 as the penetrating member 83 moves towards the patient's skin 133 or other tissue, the processor 93 also monitors and adjusts the electrical current to the coils 114-117. In some embodiments, the processor 93 applies current to an appropriate coil 114-117 such that the penetrating member 83 continues to move according to a desired direction and acceleration. In the instant case, the processor 93 applies current to the appropriate coil 114-117 that will cause the penetrating member 83 to continue to move in the direction of the patient's skin 133 or other tissue to be penetrated.

The processor 93 may successively transition the current between coils 114-117 so that as the magnetic member 102 moves past a particular coil 114-117, the processor 93 then shuts off current to that coil 114-117 and then applies current to another coil 114-117 that will attract the magnetic member 102 and cause the magnetic member 102 to continue to move in the desired direction. In transitioning current between the coils 114-117, the processor 93 can take into account various factors, including the speed of the penetrating member 83, the position of the penetrating member 83 relative to the coils 114-117, the number of coils 114-117, and the level of current to be applied to the coils 114-117 to achieve a desired speed or acceleration.

In the next operation, the processor 93 determines whether the cutting or distal end tip 96 of the penetrating member 83 has contacted the patient's skin 133, as shown in FIG. 8 and as represented by the decision box numbered 165 in FIG. 6B. The processor 93 may determine whether the penetrating member 83 has made contact with the target tissue 133 by a variety of methods, including some that rely on parameters which are measured prior to initiation of a lancing cycle and other methods that are adaptable to use during a lancing cycle without any predetermined parameters.

In one embodiment, the processor 93 determines that the skin has been contacted when the end tip 96 of the penetrating member 83 has moved a predetermined distance with respect to its initial position. If the distance from the tip 261 of the penetrating member 83 to the target tissue 133 is known prior to initiation of penetrating member 83 movement, the initial position of the penetrating member 83 is fixed and known, and the movement and position of the penetrating member 83 can be accurately measured during a lancing cycle, then the position and time of penetrating member contact can be determined.

This method requires an accurate measurement of the distance between the penetrating member tip 96 and the patient's skin 133 when the penetrating member 83 is in the zero time or initial position. This can be accomplished in a number of ways. One way is to control all of the mechanical parameters that influence the distance from the penetrating member tip 96 to the patient's tissue or a surface of the lancing device 80 that will contact the patient's skin 133. This could include the start position of the magnetic member 102, magnetic path tolerance, magnetic member 102 dimensions, driver coil pack 88 location within the lancing device 80 as a whole, length of the elongate coupling shaft 84, placement of the magnetic member 102 on the elongate coupling shaft 84, length of the penetrating member 83 etc.

If all these parameters, as well as others can be suitably controlled in manufacturing with a tolerance stack-up that is acceptable, then the distance from the penetrating member tip 96 to the target tissue 133 can be determined at the time of manufacture of the lancing device 80. The distance could then be programmed into the memory of the processor 93. If an adjustable feature is added to the lancing device 80, such as an adjustable length elongate coupling shaft 84, this can accommodate variations in all of the parameters noted above, except length of the penetrating member 83. An electronic alternative to this mechanical approach would be to calibrate a stored memory contact point into the memory of the processor 93 during manufacture based on the mechanical parameters described above.

In another embodiment, moving the penetrating member tip 96 to the target tissue 133 very slowly and gently touching the skin 133 prior to actuation can accomplish the distance from the penetrating member tip 96 to the tissue 133. The position sensor can accurately measure the distance from the initialization point to the point of contact, where the resistance to advancement of the penetrating member 83 stops the penetrating member movement. The penetrating member 83 is then retracted to the initialization point having measured the distance to the target tissue 133 without creating any discomfort to the user.

In another embodiment, the processor 93 may use software to determine whether the penetrating member 83 has made contact with the patient's skin 133 by measuring for a sudden reduction in velocity of the penetrating member 83 due to friction or resistance imposed on the penetrating member 83 by the patient's skin 133. The optical encoder 91 measures displacement of the penetrating member 83. The position output data provides input to the interrupt input of the processor 93. The processor 93 also has a timer capable of measuring the time between interrupts. The distance between interrupts is known for the optical encoder 91, so the velocity of the penetrating member 83 can be calculated by dividing the distance between interrupts by the time between the interrupts.

This method requires that velocity losses to the penetrating member 83 and elongate coupler 84 assembly due to friction are known to an acceptable level so that these velocity losses and resulting deceleration can be accounted for when establishing a deceleration threshold above which contact between penetrating member tip 96 and target tissue 133 will be presumed. This same concept can be implemented in many ways. For example, rather than monitoring the velocity of the penetrating member 83, if the processor 93 is controlling the penetrating member driver in order to maintain a fixed velocity, the power to the driver 88 could be monitored. If an amount of power above a predetermined threshold is required in order to maintain a constant velocity, then contact between the tip of the penetrating member 96 and the skin 133 could be presumed.

In yet another embodiment, the processor 93 determines skin 133 contact by the penetrating member 83 by detection of an acoustic signal produced by the tip 96 of the penetrating member 83 as it strikes the patients skin 133. Detection of the acoustic signal can be measured by an acoustic detector 136 placed in contact with the patient's skin 133 adjacent a penetrating member penetration site 137, as shown in FIG. 8. Suitable acoustic detectors 136 include piezo electric transducers, microphones and the like. The acoustic detector 136 transmits an electrical signal generated by the acoustic signal to the processor 93 via electrical conductors 138. In another embodiment, contact of the penetrating member 83 with the patient's skin 133 can be determined by measurement of electrical continuity in a circuit that includes the penetrating member 83, the patient's finger 134 and an electrical contact pad 240 that is disposed on the patient's skin 133 adjacent the contact site 137 of the penetrating member 83, as shown in FIG. 8. In this embodiment, as soon as the penetrating member 83 contacts the patient's skin 133, the circuit 139 is completed and current flows through the circuit 139. Completion of the circuit 139 can then be detected by the processor 93 to confirm skin 133 contact by the penetrating member 83.

If the penetrating member 83 has not contacted the target skin 133, then the process proceeds to a timeout operation in FIG. 6B. In the timeout operation, the processor 93 waits a predetermined time period. If the timeout period has not yet elapsed, then the processor continues to monitor whether the penetrating member has contacted the target skin 133. The processor 93 preferably continues to monitor the position and speed of the penetrating member 83, as well as the electrical current to the appropriate coil 114-117 to maintain the desired penetrating member 83 movement.

If the timeout period elapses without the penetrating member 83 contacting the skin, then it is deemed that the penetrating member 83 will not contact the skin and the process proceeds to a withdraw phase, where the penetrating member is withdrawn away from the skin 133, as discussed more fully below. The penetrating member 83 may not have contacted the target skin 133 for a variety of reasons, such as if the patient removed the skin 133 from the lancing device or if something obstructed the penetrating member 83 prior to it contacting the skin.

The processor 93 may also proceed to the withdraw phase prior to skin contact for other reasons. For example, at some point after initiation of movement of the penetrating member 83, the processor 93 may determine that the forward acceleration of the penetrating member 83 towards the patient's skin 133 should be stopped or that current to all coils 114-117 should be shut down. This can occur, for example, if it is determined that the penetrating member 83 has achieved sufficient forward velocity, but has not yet contacted the skin 133. In one embodiment, the average penetration velocity of the penetrating member 83 from the point of contact with the skin to the point of maximum penetration may be about 2.0 to about 10.0 m/s, specifically, about 3.8 to about 4.2 m/s. In another embodiment, the average penetration velocity of the penetrating member may be from about 2 to about 8 meters per second, specifically, about 2 to about 4 m/s.

The processor 93 can also proceed to the withdraw phase if it is determined that the penetrating member 83 has fully extended to the end of the power stroke of the operation cycle of lancing procedure. In other words, the process may proceed to withdraw phase when an axial center 141 of the magnetic member 102 has moved distal of an axial center 142 of the first coil 114 as show in FIG. 5. In this situation, any continued power to any of the coils 114-117 of the driver coil pack 88 serves to decelerate the magnetic member 102 and thus the penetrating member 83. In this regard, the processor 93 considers the length of the penetrating member 83 (which can be stored in memory) the position of the penetrating member 83 relative to the magnetic member 102, as well as the distance that the penetrating member 83 has traveled.

With reference again to the decision box 165 in FIG. 6B, if the processor 93 determines that the penetrating member 83 has contacted the skin 133 (a “Yes” outcome from the decision box 165), then the processor 93 can adjust the speed of the penetrating member 83 or the power delivered to the penetrating member 83 for skin penetration to overcome any frictional forces on the penetrating member 83 in order to maintain a desired penetration velocity of the penetrating member. As the velocity of the penetrating member 83 is maintained after contact with the skin 133, the distal tip 96 of the penetrating member 83 will first begin to depress or tent the contacted skin 137 and the skin 133 adjacent the penetrating member 83 to form a tented portion 243 as shown in FIG. 9 and further shown in FIG. 10. As the penetrating member 83 continues to move in a distal direction or be driven in a distal direction against the patient's skin 133, the penetrating member 83 will eventually begin to penetrate the skin 133, as shown in FIG. 11. Once penetration of the skin 133 begins, the static force at the distal tip 96 of the penetrating member 83 from the skin 133 will become a dynamic cutting force, which is generally less than the static tip force. As a result in the reduction of force on the distal tip 96 of the penetrating member 83 upon initiation of cutting, the tented portion 243 of the skin 133 adjacent the distal tip 96 of the penetrating member 83 which had been depressed as shown in FIGS. 32 and 24 will spring back as shown in FIG. 11.

In the next operation, represented by the decision box numbered 171 in FIG. 6B, the processor 93 determines whether the distal end 96 of the penetrating member 83 has reached a brake depth. The brake depth is the skin penetration depth for which the processor 93 determines that deceleration of the penetrating member 83 is to be initiated in order to achieve a desired final penetration depth 144 of the penetrating member 83 as show in FIG. 12. The brake depth may be pre-determined and programmed into the processor's memory, or the processor 93 may dynamically determine the brake depth during the actuation. The amount of penetration of the penetrating member 83 in the skin 133 of the patient may be measured during the operation cycle of the penetrating member device 80. In addition, as discussed above, the penetration depth suitable for successfully obtaining a useable sample can depend on the amount of tenting of the skin 133 during the lancing cycle. The amount of tenting of the patient's skin 133 can in turn depend on the tissue characteristics of the patient such as elasticity, hydration etc. A method for determining these characteristics is discussed below with regard to skin 133 tenting measurements during the lancing cycle and illustrated in FIGS. 37-41.

Penetration measurement can be carried out by a variety of methods that are not dependent on measurement of tenting of the patient's skin. In one embodiment, the penetration depth of the penetrating member 83 in the patient's skin 133 is measured by monitoring the amount of capacitance between the penetrating member 83 and the patients skin 133. In this embodiment, a circuit includes the penetrating member 83, the patient's finger 134, the processor 93 and electrical conductors connecting these elements. As the penetrating member 83 penetrates the patient's skin 133, the greater the amount of penetration, the greater the surface contact area between the penetrating member 83 and the patient's skin 133. As the contact area increases, so does the capacitance between the skin 133 and the penetrating member 83. The increased capacitance can be easily measured by the processor 93 using methods known in the art and penetration depth can then be correlated to the amount of capacitance. The same method can be used by measuring the electrical resistance between the penetrating member 83 and the patient's skin.

If the brake depth has not yet been reached, then a “No” results from the decision box 171 and the process proceeds to the timeout operation represented by the flow diagram box numbered 173. In the timeout operation, the processor 93 waits a predetermined time period. If the timeout period has not yet elapsed (a “No” outcome from the decision box 173), then the processor continues to monitor whether the brake depth has been reached. If the timeout period elapses without the penetrating member 83 achieving the brake depth (a “Yes” output from the decision box 173), then the processor 93 deems that the penetrating member 83 will not reach the brake depth and the process proceeds to the withdraw phase, which is discussed more fully below. This may occur, for example, if the penetrating member 83 is stuck at a certain depth.

With reference again to the decision box numbered 171 in FIG. 6B, if the penetrating member does reach the brake depth (a “Yes” result), then the process proceeds to the operation represented by the flow diagram box numbered 275. In this operation, the processor 93 causes a braking force to be applied to the penetrating member to thereby reduce the speed of the penetrating member 83 to achieve a desired amount of final skin penetration depth 144, as shown in FIG. 26. Note that FIGS. 32 and 33 illustrate the penetrating member making contact with the patient's skin and deforming or depressing the skin prior to any substantial penetration of the skin. The speed of the penetrating member 83 is preferably reduced to a value below a desired threshold and is ultimately reduced to zero. The processor 93 can reduce the speed of the penetrating member 83 by causing a current to be sent to a 114-117 coil that will exert an attractive braking force on the magnetic member 102 in a proximal direction away from the patients tissue or skin 133, as indicated by the arrow 190 in FIG. 13. Such a negative force reduces the forward or distally oriented speed of the penetrating member 83. The processor 93 can determine which coil 114-117 to energize based upon the position of the magnetic member 102 with respect to the coils 114-117 of the driver coil pack 88, as indicated by the position sensor 91.

In the next operation, the process proceeds to the withdraw phase, as represented by the flow diagram box numbered 177. The withdraw phase begins with the operation represented by the flow diagram box numbered 178 in FIG. 6C. Here, the processor 93 allows the penetrating member 83 to settle at a position of maximum skin penetration 144, as shown in FIG. 12. In this regard, the processor 93 waits until any motion in the penetrating member 83 (due to vibration from impact and spring energy stored in the skin, etc.) has stopped by monitoring changes in position of the penetrating member 83. The processor 93 preferably waits until several milliseconds (ms), such as on the order of about 8 ms, have passed with no changes in position of the penetrating member 83. This is an indication that movement of the penetrating member 83 has ceased entirely. In some embodiments, the penetrating member may be allowed to settle for about 1 to about 2000 milliseconds, specifically, about 50 to about 200 milliseconds. For other embodiments, the settling time may be about 1 to about 200 milliseconds.

It is at this stage of the lancing cycle that a software method can be used to measure the amount of tenting of the patient's skin 133 and thus determine the skin 133 characteristics such as elasticity, hydration and others. Referring to FIGS. 37-41, a penetrating member 83 is illustrated in various phases of a lancing cycle with target tissue 133. FIG. 14 shows tip 96 of penetrating member 83 making initial contact with the skin 133 at the point of initial impact.

FIG. 15 illustrates an enlarged view of the penetrating member 83 making initial contact with the tissue 133 shown in FIG. 14. In FIG. 16, the penetrating member tip 96 has depressed or tented the skin 133 prior to penetration over a distance of X, as indicated by the arrow labeled X in FIG. 16. In FIG. 17, the penetrating member 83 has reached the full length of the cutting power stroke and is at maximum displacement. In this position, the penetrating member tip 96 has penetrated the tissue 133 a distance of Y, as indicated by the arrow labeled Y in FIG. 16. As can be seen from comparing FIG. 15 with FIG. 17, the penetrating member tip 96 was displaced a total distance of X plus Y from the time initial contact with the skin 133 was made to the time the penetrating member tip 96 reached its maximum extension as shown in FIG. 17. However, the penetrating member tip 96 has only penetrated the skin 133 a distance Y because of the tenting phenomenon.

At the end of the power stroke of the penetrating member 83, as discussed above with regard to box 179 of FIG. 6C, the processor 93 allows the penetrating member to settle for about 8 msec. It is during this settling time that the skin 133 rebounds or relaxes back to approximately its original configuration prior to contact by the penetrating member 83 as shown in FIG. 18. The penetrating member tip 96 is still buried in the skin to a depth of Y, as shown in FIG. 18, however the elastic recoil of the tissue has displaced the penetrating member rearward or retrograde to the point of inelastic tenting that is indicated by the arrows Z in FIG. 18. During the rearward displacement of the penetrating member 83 due to the elastic tenting of the tissue 133, the processor reads and stores the position data generated by the position sensor 91 and thus measures the amount of elastic tenting, which is the difference between X and Z.

Referring to FIG. 19, a tissue penetration sampling device 80 is shown with the controllable driver 179 of FIG. 4 coupled to a sampling module cartridge 205 and disposed within a driver housing 206. A ratchet drive mechanism 207 is secured to the driver housing 206, coupled to the sampling module cartridge 205 and configured to advance a sampling module belt 208 within the sampling module cartridge 205 so as to allow sequential use of each sampling module 209 in the sampling module belt 208. The ratchet drive mechanism 207 has a drive wheel 211 configured to engage the sampling modules 209 of the sampling module belt 208. The drive wheel 211 is coupled to an actuation lever 212 that advances the drive wheel 211 in increments of the width of a single sampling module 209. A T-slot drive coupler 213 is secured to the elongated coupler shaft 84.

A sampling module 209 is loaded and ready for use with the drive head 98 of the penetrating member 83 of the sampling module 209 loaded in the t-slot 214 of the drive coupler 213. A sampling site 215 is disposed at the distal end 216 of the sampling module 209 disposed about a penetrating member exit port 217. The distal end 216 of the sampling module 209 is exposed in a module window 218, which is an opening in a cartridge cover 221 of the sampling module cartridge 205. This allows the distal end 216 of the sampling module 209 loaded for use to be exposed to avoid contamination of the cartridge cover 221 with blood from the lancing process.

A reader module 222 is disposed over a distal portion of the sampling module 209 that is loaded in the drive coupler 213 for use and has two contact brushes 224 that are configured to align and make electrical contact with analyte detecting member contacts 225 of the sampling module 209 as shown in FIG. 77. With electrical contact between the analyte detecting member contacts 225 and contact brushes 224, the processor 93 of the controllable driver 179 can read a signal from an analytical region 226 of the sampling module 209 after a lancing cycle is complete and a blood sample enters the analytical region 226 of the sampling module 209. The contact brushes 224 can have any suitable configuration that will allow the sampling module belt 208 to pass laterally beneath the contact brushes 224 and reliably make electrical contact with the sampling module 209 loaded in the drive coupler 213 and ready for use. A spring loaded conductive ball bearing is one example of a contact brush 224 that could be used. A resilient conductive strip shaped to press against the inside surface of the flexible polymer sheet 227 along the analyte detecting member region 228 of the sampling module 209 is another embodiment of a contact brush 224.

The sampling module cartridge 205 has a supply canister 229 and a receptacle canister 230. The unused sampling modules of the sampling module belt 208 are disposed within the supply canister 229 and the sampling modules of the sampling module belt 208 that have been used are advanced serially after use into the receptacle canister 230.

FIG. 20 illustrates a further embodiment of sampling module cartridges. FIG. 20 shows a sampling module cartridge 202 in a carousel configuration with adjacent sampling modules 204 connected rigidly and with analyte detecting members 206 from the analytical regions of the various sampling modules 204 disposed near an inner radius 208 of the carousel. The sampling modules 204 of the sampling module cartridge 202 are advanced through a drive coupler 213 but in a circular as opposed to a linear fashion.

FIG. 21 shows an exploded view in perspective of the cartridge 245, which has a proximal end portion 254 and a distal end portion 255. The penetrating member cartridge body 246 is disposed at the proximal end portion 254 of the cartridge 245 and has a plurality of penetrating member module portions 250, such as the penetrating member module portion 250. Each penetrating member module portion 250 has a penetrating member channel 251 with a penetrating member 83 slidably disposed within the penetrating member channel 251. The penetrating member channels 251 are substantially parallel to the longitudinal axis 252 of the penetrating member cartridge body 246. The penetrating members 83 shown have a drive head 98, shaft portion 201 and sharpened tip 96. The drive head 98 of the penetrating members are configured to couple to a drive coupler (not shown), such as the drive coupler 85 discussed above.

The penetrating members 83 are free to slide in the respective penetrating member channels 251 and are nominally disposed with the sharpened tip 96 withdrawn into the penetrating member channel 251 to protect the tip 96 and allow relative rotational motion between the penetrating member cartridge body 246 and the sampling cartridge body 247 as shown by arrow 256 and arrow 257 in FIG. 21. The radial center of each penetrating member channel 251 is disposed a fixed, known radial distance from the longitudinal axis 252 of the penetrating member cartridge body 246 and a longitudinal axis 258 of the cartridge 245. By disposing each penetrating member channel 251 a fixed known radial distance from the longitudinal axes 252 and 258 of the penetrating member cartridge body 246 and cartridge 245, the penetrating member channels 251 can then be readily and repeatably aligned in a functional arrangement with penetrating member channels 253 of the sampling cartridge body 247. The penetrating member cartridge body 246 rotates about a removable pivot shaft 259 which has a longitudinal axis 260 that is coaxial with the longitudinal axes 252 and 250 of the penetrating member cartridge body 246 and cartridge 245.

The sampling cartridge body 247 is disposed at the distal end portion 255 of the cartridge and has a plurality of sampling module portions 248 disposed radially about the longitudinal axis 249 of the sampling cartridge body 247. The longitudinal axis 249 of the sampling cartridge body 247 is coaxial with the longitudinal axes 252, 258 and 260 of the penetrating member cartridge body 246, cartridge 245 and pivot shaft 259. The sampling cartridge body 247 may also rotate about the pivot shaft 259. In order to achieve precise relative motion between the penetrating member cartridge body 246 and the sampling cartridge body 247, one or both of the cartridge bodies 246 and 247 may be rotatable about the pivot shaft 259, however, it is not necessary for both to be rotatable about the pivot shaft 259, that is, one of the cartridge bodies 246 and 247 may be secured, permanently or removably, to the pivot shaft 259.

The sampling cartridge body 247 includes a base 261 and a cover sheet 262 that covers a proximal surface 263 of the base forming a fluid tight seal. Each sampling module portion 248 of the sampling cartridge body 247, such as the sampling module portion 248, has a sample reservoir 264 and a penetrating member channel 253. The sample reservoir 264 has a vent 965 at an outward radial end that allows the sample reservoir 264 to readily fill with a fluid sample. The sample reservoir 264 is in fluid communication with the respective penetrating member channel 253 which extends substantially parallel to the longitudinal axis 249 of the sampling cartridge body 247. The penetrating member channel 253 is disposed at the inward radial end of the sample reservoir 264. Still further description of the device of FIG. 21 may be found in commonly assigned, copending U.S. patent application Ser. No. 10/127,395 filed Apr. 19, 2002.

Referring to FIG. 22A, one embodiment of the present invention is a tissue penetrating system 310 with a plurality of penetrating members 312 that each have a tissue penetrating tip 314. The number of penetrating members 310 can vary, but numbers in the ranges of 10, 15, 25, 50, 75, 100, 500 or any other number, are suitable. Each penetrating member 312 can be a lancet, a traditional lancet with a molded body, a needle with a lumen, a knife like element, an elongate member without molded attachments, and the like, and may have a size in the range of 20 mm to 10 mm in length and between 0.012-0.040 mm in diameter. It should be understood of course that penetrating members of a variety of different sizes useful for lancing such as those of conventional lancets may be used in other embodiments. As seen in FIG. 22A, the penetrating member may have an elongate portion with a bend near a proximal end of the member.

Each penetrating member 312 is coupled to a penetrating member driver 316. Suitable penetrating member drivers 316 include but are not limited to, an electric drive force member, a voice coil drive force generator, a linear voice coil device, a rotary voice coil device, and the like. Suitable drive force generators can be found in commonly assigned, copending U.S. patent application Ser. No. 10/127,395 filed Apr. 19, 2002. In one embodiment, the penetrating member driver or drive force generator 316 may be a single actuator used to advance the penetrating member and to withdraw the member. The driver 316 may also be used to stop the penetrating member in the tissue site. Penetrating member driver 316 can be a non-spring actuator for drawing penetrating member 312 in a direction back towards penetrating member driver 316. A coupler 318 on penetrating member driver 316 is configured to engage at least a portion of an elongate portion of a penetrating member 312 in order to drive the penetrating member 312 along a path into and through target tissue 320, and then withdrawn from target tissue 320.

Referring now to FIG. 22B, the tips of the penetrating members 312 can be uncovered when they are launched into a selected target tissue 320. In one embodiment, sterility enclosures 322 are provided for covering at least the tip of each penetrating member 312. FIG. 22B shows that the enclosure may also cover the entire lancet. In one embodiment, each sterility enclosure 322 is removed from the penetrating member 312 prior to actuation, launch, of penetrating member 312 and positioned so that penetrating member 312 does not contact the associated sterility enclosure 322 during actuation. As seen in FIG. 22B, the enclosure 322 may be peel away to reveal the penetrating member 312 prior to coupling of the member 312 to the drive force generator 316. In another embodiment, each penetrating member 312 breaches its associated sterility enclosure 322 during launch.

Tissue penetrating system 310 can also include one or more penetrating member sensors 324 that are coupled to penetrating members 312. Examples of suitable penetrating member sensors 324 include but are not limited to, a capacitive incremental encoder, an incremental encoder, an optical encoder, an interference encoder, and the like. Each penetrating member sensor 324 is configured to provide information relative to a depth of penetration of a penetrating member 312 through a target tissue 320 surface, including but not limited to a skin surface, and the like. The penetrating member sensor 324 may be positioned as shown in FIG. 22B. The penetrating member sensor 324 may also be positioned in a variety of location such as but not limited to being closer to the distal end of the penetrating member, in a position as shown in FIG. 5, or in any other location useful for providing an indication of the position of a penetrating member 312 being driven by the force generator 316.

In various embodiments, the penetration depth of a penetrating member 312 through the surface of a target tissue 320 can be, 100 to 2500 microns, 500 to 750 microns, and the like. Each penetrating member sensor 324 can also provide an indication of velocity of a penetrating member 312. Referring to FIG. 22C, a damper 326 can be coupled to penetrating member driver 316. Damper 326 prevents multiple oscillations of penetrating member 312 in target tissue 320, particularly after penetrating member 312 has reached a desired depth of penetration. The damper 326 may be placed in a variety of positions such as but not limited to being coupled to the penetrating member, being coupled to the coupler 318, being coupled to a core or shaft in the drive force generator 316, or at any other position useful for slowing the motion of the penetrating member 312.

A feedback loop 328 can also be included that is coupled to penetrating member sensor 324. Each penetrating member 312 sensor can be coupled to a processor 330 that has control instructions for penetrating member driver 316. By way of illustration, and without limitation, processor 330 can include a memory for storage and retrieval of a set of penetrating member 312 profiles utilized with penetrating member driver 316. Processor 330 can also be utilized to monitor position and speed of a penetrating member 312 as it moves in first direction 332 to and through the target tissue 320.

Processor 330 can adjust an application of force to a penetrating member 312 in order to achieve a desired speed of a penetrating member 312. Additionally, processor 330 can also be used to adjust an application of force applied to a penetrating member 312 when penetrating member 312 contacts target tissue 320 so that penetrating member 312 penetrates target tissue 320 within a desired range of speed. Further, processor 330 can also monitor position and speed of a penetrating member 312 as penetrating member 312 moves in first direction 332 toward the target tissue 320. Application of a launching force to penetrating member 312 can be controlled based on position and speed of penetrating member 312. Processor 330 can control a withdraw force, from target tissue 320, to penetrating member 312 so that penetrating member 312 moves in second direction 334 away from target tissue 320.

Processor 330 can produce a signal that is indicative of a change in direction and magnitude of force exerted on penetrating member 312. Additionally, processor 330 can cause a braking force to be applied to penetrating member 312.

In one embodiment, in first direction 332 penetrating member 312 moves toward target tissue 320 at a speed that is different than a speed at which penetrating member 312 moves away from target tissue 320 in second direction 334. In one embodiment, the speed of penetrating member 312 in first direction 332 is greater than the speed of penetrating member 312 in second direction 334. The speed of penetrating member 312 in first direction 332 can be a variety of different ranges including but not limited to, 0.05 to 60 m/sec, 0.1 to 20.0 M/se, 1.0 to 10.0 m/sec, 3.0 to 8.0 m/sec, and the like. Additionally, the dwell time of penetrating member 312 in target tissue 320, below a surface of the skin or other structure, can be in the range of, 1 microsecond to 2 seconds, 500 milliseconds to 1.5 second, 100 milliseconds to 1 second, and the like.

As seen in FIGS. 22A and 22B, tissue penetrating system 310 can include a penetrating member transport device 336 for moving each of penetrating member 312 into a position for alignment with penetrating member driver 316. Penetrating members 312 can be arranged in an array configuration by a number of different devices and structures defining support 338, including but not limited to, a belt, a flexible or non-flexible tape device, support channel, cog, a plurality of connectors, and the like. Support 338 can have a plurality of openings each receiving a penetrating member 312. Suitable supports 338 may also include but are not limited to, a bandolier, drum, disc and the like. A description of supports 338 can be found in U.S. patent application Ser. No. 10/127,395 filed Apr. 19, 2002; commonly assigned, copending U.S. Provisional Patent Application Ser. No. 60/437,359, filed Dec. 31, 2002; and commonly assigned, copending U.S. Provisional Patent Application Ser. No. 60/437,205, filed Dec. 31, 2002. All applications listed above are fully incorporated herein by reference for all purposes.

As illustrated in FIG. 22(a), tissue penetrating system 310 can include a single penetrating member driver 316 and a plurality of penetrating members 312. Penetrating member driver 316 moves each penetrating member 312 along a path out of a housing that has a penetrating member exit and then into target tissue 320, stopping in target tissue 320, and then withdrawing out of the target tissue 320. Support 338 couples the penetrating members 312 to define a linear array. Support 338 is movable and configured to move each penetrating member 312 to a launch position associated with penetrating member driver 316. Penetrating member driver 316 can be controlled to follow a predetermined velocity trajectory into and out of target tissue 320.

Tissue penetrating system 310 can include a user interface 340 configured to relay different information, including but not limited to, skin penetrating performance, a skin penetrating setting, and the like. User interface 340 can provide a user with at a variety of different outputs, including but not limited to, penetration depth of a penetrating member 312, velocity of a penetrating member 312, a desired velocity profile, a velocity of penetrating member 312 into target tissue 320, velocity of the penetrating member 312 out of target tissue 320, dwell time of penetrating member 312 in target tissue 320, a target tissue relaxation parameter, and the like. User interface 340 can include a variety of components including but not limited to, a real time clock 342, one or more alarms 344 to provide a user with a reminder of a next target penetrating event is needed, a user interface processor 346, and the like.

User interface 340 can provide a variety of different outputs to a user including but not limited to, number of penetrating members 312 available, number of penetrating members 312 used, actual depth of penetrating member 312 penetration on target tissue 320, stratum corneum thickness in the case where the target tissue 320 is the skin and an area below the skin, force delivered on target tissue 320, energy used by penetrating member driver 316 to drive penetrating member 312 into target tissue 320, dwell time of penetrating member 312, battery status of tissue penetrating system 310, status of tissue penetrating system 310, the amount of energy consumed by tissue penetrating system 310, or any component of tissue penetrating system 310, speed profile of penetrating member 312, information relative to contact of penetrating member 312 with target tissue 320 before penetration by penetrating member 312, information relative to a change of speed of penetrating member 312 as in travels in target tissue 320, and the like.

User interface 340 can include a data interface 348 that couples tissue penetrating system 310 to support equipment 350 with an interface, the internet, and the like. The data interface 348 may also be coupled to the processor 93. Suitable support equipment 350 includes but is not limited to, a base station, home computer, central server, main processing equipment for storing analyte, such as glucose, level information, and the like.

Data interface 348 can be a variety of interfaces including but not limited to, Serial RS-232, modem interface, USB, HPNA, Ethernet, optical interface, IRDA, RF interface, Bluetooth interface, cellular telephone interface, two-way pager interface, parallel port interface standard, near field magnetic coupling, RF transceiver, telephone system, and the like.

User interface 340 be coupled to a memory 352 that stores, a target tissue parameter, target tissue 320 penetrating performance, and the like. The memory 352 may also be connected to processor 93 and store data from the user interface 340.

In one embodiment, memory 352 can store, the number of target tissue penetrating events, time and date of the last selected number of target tissue penetrating events, time interval between alarm and target tissue penetrating event, stratum corneum thickness, time of day, energy consumed by penetrating member driver 316 to drive penetrating member 312 into target tissue 320, depth of penetrating member 312 penetration, velocity of penetrating member 312, a desired velocity profile, velocity of penetrating member 312 into target tissue 320, velocity of penetrating member 312 out of target tissue 320, dwell time of penetrating member 312 in target tissue 320, a target tissue relaxation parameter, force delivered on target tissue 320 by any component of tissue penetrating device, dwell time of penetrating member 312, battery status of tissue penetrating system 310, tissue penetrating system 310 status, consumed energy by tissue penetrating system 310 or any of its components, speed profile of penetrating member 312 as it penetrates and advances through target tissue 320, a tissue target tissue relaxation parameter, information relative to contact of penetrating member 312 with target tissue 320 before penetration by penetrating member 312, information relative to a change of speed of penetrating member 312 as in travels in and through target tissue 320, information relative to consumed analyte detecting members, and information relative to consumed penetrating members 312.

In one embodiment, processor 330 is coupled to and receives any of a different type of signals from user interface 340. User interface 340 can respond to a variety of different commands, including but not limited to audio commands, and the like. User interface 340 can include a sensor for detecting audio commands. Information can be relayed to a user of tissue penetrating system 310 by way of an audio device, wireless device 329, and the like.

In another embodiment as seen in FIG. 23B, tissue penetrating device includes a human interface 354 with at least one output. The human interface 354 is specific for use by humans while a user interface 340 may be for any type of user, with user defined generically. Human interface 354 can be coupled to processor 330 and penetrating member sensor 324. Human interface 354 can be a variety of different varieties including but not limited to, LED, LED digital display, LCD display, sound generator, buzzer, vibrating device, and the like.

The output of human interface 354 can be a variety of outputs including but not limited to, a penetration event by penetrating member 312, number of penetrating members 312 remaining, time of day, alarm, penetrating member 312 trajectory waveform profile information, force of last penetration event, last penetration event, battery status of tissue penetrating system 310, analyte status, time to change cassette status, jamming malfunction, tissue penetrating system 310 status, and the like.

Human interface 354 is coupled to a housing 356. Suitable housings 356 include but are not limited to a, telephone, watch, PDA, electronic device, medical device, point of care device, decentralized diagnostic device and the like. An input device 358 is coupled to housing. Suitable input devices 358 include but are not limited to, one or more pushbuttons, a touch pad independent of the display device, a touch sensitive screen on a visual display, and the like.

A data exchange device 360 can be utilized for coupling tissue penetrating system 310 to support equipment 350 including but not limited to, personal computer, modem, PDA, computer network, and the like. Human interface 354 can include a real time clock 362, and one or more alarms 364 that enable a user to set and use for reminders for the next target tissue penetration event. Human interface 354 can be coupled to a human interface processor 366 which is distinct from processor 330. Human interface processor 366 can include a sleep mode and can run intermittently to conserve power. Human interface processor 366 includes logic that can provide an alarm time set for a first subset of days, and a second alarm time set for a second subset of days. By way of example, and without limitation, the first subset of days can be Monday through Friday, and the second subset of days can be Saturday and Sunday.

Human interface 354 can be coupled to a memory 368 for storing a variety of information, including but not limited to, the number of target tissue penetrating events, time and date of the last selected number of target tissue penetrating events, time interval between alarm and target tissue penetrating event, stratum corneum thickness when target tissue 320 is below the skin surface and underlying tissue, time of day, energy consumed by penetrating member driver 316 to drive penetrating member 312 into target tissue 320, depth of penetrating member 312 penetration, velocity of penetrating member 312, a desired velocity profile, velocity of penetrating member 312 into target tissue 320, velocity of penetrating member 312 out of target tissue 320, dwell time of penetrating member 312 in target tissue 320, a target tissue relaxation parameter, force delivered on target tissue 320, dwell time of penetrating member 312, battery status of tissue penetrating system 310 and its components, tissue penetrating system 310 status, consumed energy, speed profile of penetrating member 312 as it advances through target tissue 320, a target tissue relaxation parameter, information relative to contact of a penetrating member 312 with target tissue 320 before penetration by penetrating member 312, information relative to a change of speed of penetrating member 312 as in travels in target tissue 320, information relative to consumed sensors, information relative to consumed penetrating members 312.

As illustrated in FIG. 24, tissue penetrating system 310 can include a penetrating member driver 316 and a plurality of cartridges 370. Each cartridge 370 contains a penetrating member 312. The cartridges 370 can be coupled together in an array, which can be a flexible array. A cartridge transport device 372 moves cartridges 370 into a launch position that operatively couples a penetrating member 312 to penetrating member driver 316. A support couples cartridges 370 to define an array. A plurality of sterility enclosures 322 can be provided to at least cover tips of penetrating members 312. Sterility enclosure 322 (shown in phantom) is removed from their associated penetrating members 312 prior to launch of the penetrating member 312. The enclosure may be peeled away (not shown) in a manner similar to that as seen in FIG. 22B, with the enclosure 322 on one tape surface being peeled away. The enclosure 322 may be a blister sack, a sack tightly formed about each cartridge 370, or other enclosure useful for maintaining a sterile environment about the cartridge 370 prior to actuation or launch. The enclosure 322 may contain the entire cartridge 370 or some portion of the cartridge 370 which may need to remain sterile prior to launch. During launch, enclosure or sterility barrier 322 can be breached by a device other than penetrating member 312, or can be breached by penetrating member 312 itself. An analyte detection member, sensor, may be positioned to receive fluid from a wound created by the penetrating member 312. The member may be on the cartridge 370 or may be on the device 80.

Referring to FIGS. 24 and 25, one embodiment of tissue penetrating system 310 includes cartridge transport device 372 and a plurality of cartridges 370. Each cartridge 370 is associated with a penetrating member 312. Cartridge transport device 372 moves each cartridge 370 to a position to align the associated penetrating member 312 with penetrating member driver 316 to drive penetrating member 312 along a path into target tissue 320. In one embodiment as seen in FIG. 25, each cartridge 370 has at least one of a distal port 374 and a proximal port 376. A first seal 378 is positioned at distal or proximal ports. As seen in FIG. 25, the seal 378 may be placed at the distal port. First seal 378 is formed of a material that is fractured by penetrating member 312 before it is launched. A second seal 380 can be positioned at the other port. It will be appreciated that only one or both of distal and proximal ports 374 and 376 can be sealed, and that each cartridge 370 can include only one port 374 and 376. For ease of illustration, the penetrating member 312 extending longitudinally through the lumen in the cartridge 370 is not shown. The seals 380 and 378 may be fracturable seals formed between the penetrating member and the cartridge 370. During actuation, the seals 378 and 380 are broken. Seal 378 may be also be positioned to cover the distal port or exit port 374 without being sealed against the penetrating member (i.e. covering the port without touching the penetrating member). A third seal 381 may be positioned to cover an entrance to sample chamber 384. The seal 381 may be configured to be broken when the penetrating member 312 is actuated. A still further seal 381A may be placed in the lumen. The tip of a penetrating member may be located at any position along the lumen, and may also be at or surrounded by one of the seals 378, 381, 381A, or 376.

Referring still to FIG. 25, a cover sheet 383 may be a flexible polymer sheet as described in commonly assigned, copending U.S. patent application Ser. No. 10/127,395 filed Apr. 19, 2002. It should be understood of course that the sheet may be made of a variety of materials useful for coupling an analyte detecting member 390. This allows the analyte detecting member 390 to be sterilized separately from the cartridge 370 and assembled together with the cartridge at a later time. This process may be used on certain analyte detecting members 390 that may be damaged if exposed to the sterilization process used on the cartridge 370. Of course, some embodiments may also have the analyte detecting member 390 coupled to the cartridge 370 during sterilization. The cover sheet 383 may also form part of the seal to maintain a sterile environment about portions of the penetrating member. In other embodiments, the lumen housing penetrating member may be enclosed and not use a sheet 383 to help form a sterile environment. In still further embodiments, the sheet 383 may be sized to focus on covering sample chamber 384.

As illustrated in FIG. 26, cartridge 370 has at least one port 374. A plurality of penetrating members 312 are in cartridge 370. Although cartridge 370 is shown in FIG. 26 to have a linear design, the cartridge 370 may also have a curved, round, circular, triangular, or other configuration useful for positioning a penetrating member for use with a drive force generator. A seal 382 is associated with each penetrating member 312 in order to maintain each penetrating member 312 in a sterile environment in cartridge 370 prior to launch. Prior to launch, seal 382 associated with the penetrating member 312 to be launched is broken. In one embodiment, a punch (not shown) is used to push down on the seal 382 covering the port 376 of the cartridge 370. This breaks the seal 382 and also pushes it downward, allowing the penetrating member to exit the cartridge without contacting the seal 382. The timing of the breaking of the seal 382 may be varied so long as the penetrating member remains substantially sterile when being launched towards the tissue site 320. In other embodiments, the port 376 may have a seal 383 that protrudes outward and is broken off by the downward motion of the punch. One or more sample chambers 384 are included in cartridge 370. In one embodiment, each penetrating member 312 has an associated sample chamber 384. In one embodiment, illustrated in FIG. 27, penetrating member 312 is extendable through an opening 386 of its associated sample chamber 384. In some embodiments, a seal 387 may be included in the sample chamber 384. Seals 382 and 387 may be made from a variety of materials such as but not limited to metallic foil, aluminum foil, paper, polymeric material, or laminates combining any of the above. The seals may also be made of a fracturable material. The seals may be made of a material that can easily be broken when a device applies a force thereto. The seals alone or in combination with other barriers may be used to create a sterile environment about at least the tip of the penetrating member prior to lancing or actuation.

With reference now to the embodiment of FIG. 28, each sample chamber 384 may have an opening 388 for transport of a body fluid into the sample chamber 384. The size of sample chambers 384 in FIGS. 26 through 28 can vary. In various embodiments, sample chambers 384 are sized to receive, no more than 1.0 μL of the body fluid, no more than 0.75 μL of the body fluid, no more than 0.5 μL of the body fluid, no more than 0.25 μL of the body fluid, no more than 0.1 μL of the body fluid, and the like. It will be appreciated that sample chambers 384 can have larger or smaller sizes.

An analyte detecting member 390 may associated with each sample chamber 384. The analyte detecting member 390 may be designed for use with a variety of different sensing techniques as described in commonly assigned, copending U.S. patent application Ser. No. 10/127,395 filed Apr. 19, 2002. Analyte detecting member 390 can be positioned in sample chamber 384, at an exterior of sample chamber 384, or at other locations useful for obtaining an analyte. Analyte detecting member 390 can be in a well 392, or merely be placed on a support.

In one embodiment, analyte detecting member 390 includes chemistries that are utilized to measure and detect glucose, and other analytes. In another embodiment, analyte detecting member 390 is utilized to detect and measure the amount of different analytes in a body fluid or sample. In various embodiments, analyte detecting member 390 determines a concentration of an analyte in a body fluid using a sample that does not exceed a volume of, 1 μL of a body fluid disposed in sample chamber 384, 0.75 μL of a body fluid disposed in sample chamber 384, 0.5 μL of a body fluid disposed in sample chamber 384, 0.25 μL of a body fluid disposed in sample chamber 384, 0.1 μL of a body fluid disposed in sample chamber 384, and the like. For example and not by way of limitation, the sample chamber 384 may be of a size larger than the volumes above, but the analyte detecting member 390 can obtain an analyte reading using the amounts of fluid described above.

As illustrated in FIG. 29, tissue penetrating system 310 can include a housing member 394, a penetrating member 312 positioned in housing member 394, and analyte detecting member 390 coupled to a sample chamber 384. Analyte detecting member 390 is configured to determine a concentration of an analyte in a body fluid using with a variety of different body fluid, sample, volumes. In various embodiments, the volume is less than 1 μL of body fluid disposed in sample chamber 384, 0.75 of body fluid disposed in sample chamber 384, 0.5 of body fluid disposed in sample chamber 384, 0.25 of body fluid disposed in sample chamber 384, 0.1 of body fluid disposed in sample chamber 384 and the like. Each tip of a penetrating member 312 is configured to extend through an opening of sample chamber 384. A plurality of penetrating members 312 can be positioned in housing member 394. Housing member 394 can be the same as cartridge 370. Cartridge 370 can have distal and proximal ports 374 and 376, respectively. Additionally, in this embodiment, a plurality of cartridges 370 can be provided, each associated with a penetrating member 312.

Referring to FIG. 30, each penetrating member 312 has a packing density, or occupied volume, in cartridge 370. In various embodiments, the packing density of each penetrating member 312 in cartridge 370 can be no more than, 5.0 cm3/penetrating member 312, 4.0 cm3/penetrating member 312, 3.0 cm3/penetrating member 312, 2.0 cm3/penetrating member 312, 1.0 cm3/penetrating member 312, 0.75 cm3/penetrating member 312, 0.5 cm3/penetrating member 312, 0.25 cm3/penetrating member 312, 0.1 cm3/penetrating member 312, and the like. In other words, the volume required for each penetrating member does not exceed 5.0 cm3/penetrating member 312, 4.0 cm3/penetrating member 312, 3.0 cm3/penetrating member 312, 2.0 cm3/penetrating member 312, 1.0 cm3/penetrating member 312, 0.75 cm3/penetrating member 312, 0.5 cm3/penetrating member 312, 0.25 cm3/penetrating member 312, 0.1 cm3/penetrating member 312, and the like. So, as seen in FIG. 30, if the total package volume of the cartridge is defined as X and the cartridge includes Y number of penetrating members 312, penetrating members 312 and test area, or other unit 395, the volume for each unit does not exceed 5.0 cm3/unit, 4.0 cm3/unit, 3.0 cm3/unit, 2.0 cm3/unit, 1.0 cm3/unit, 0.75 cm3/unit, 0.5 cm3/unit, 0.25 cm3/unit, 0.1 cm3/unit, and the like.

In various embodiments, each penetrating member 312 and its associated sample chamber 384 have a combined packing density of no more than about 5.0 cm3, 4.0 cm3, 3.0 cm3, 2.0 cm3, 1.0 cm3, 0.75 cm3, 0.5 cm3, 0.25 cm3, 0.1 cm3, and the like.

With reference now to FIG. 31, tissue penetrating system 310 can have a first seal 378 formed at distal port 374 and a second seal 380 formed at proximal port 376 of cartridge 370. Prior to launching of penetrating member 312, distal seal 378 and second seal 380 maintain a distal tip of penetrating member 312 and sample chamber 384 in a sterile environment. Second seal 380 is breached, and penetrating member 312 is then launched.

As illustrated in FIG. 32, a plurality of lumens 396 can be positioned between distal port 374 and proximal port 376 of cartridge 370 for slidably receiving a penetrating member 312. Sample chamber 384 is defined by cartridge 370, has an opening 398 and is associated with penetrating member 312. First seal 378 covers distal port 374, and a second seal 380 covers proximal port 376.

In another embodiment as shown in FIG. 33, tissue penetrating system 310 includes a plurality of cartridges 370, penetrating member driver 316, and a plurality of penetrating members 312 coupled to penetrating member driver 316. Each penetrating member 312 is associated with a cartridge 370. A plurality of gas-tightly sealed enclosures 400 are coupled in an array. Each enclosure 400 fully contains at least one of cartridge 370. Enclosures 400 are configured to be advanceable on cartridge transport device 372 that individually releases cartridges 370 from sacks or enclosures 400 and loads them individually onto penetrating member driver 316. The enclosures 400 may be removed by peeling back a top portion of the tape as shown in FIG. 22B.

In another embodiment, a plurality of penetrating members 312 each have a sharpened distal tip. A penetrating member driver 316 is coupled to each penetrating member 312. A plurality of cartridges 370 are coupled in an array. Each cartridge 370 houses a penetrating member 312 and is configured to permit penetrating member driver 316 to engage each of penetrating members 312 sequentially. Each cartridge 370 has a plurality of seals positioned to provide that the sharpened distal tips remain in a sterile environment before penetrating target tissue 320. Penetrating members 312 are launched without breaking a seal using the penetrating member.

Referring now to FIG. 34, a plurality of cartridges 370 are provided, each having distal and proximal ports 374 and 376, respectively. A plurality of penetrating members 312 are each associated with a cartridge 370. Each penetrating member 312 has a sharpened distal tip and a shaft portion slidably disposed within cartridge 370. As seen in FIG. 34, the cartridges 370 may be coupled together by a connector or flexible support 403. A seal 404 is formed by a fracturable material between the penetrating member 312 and each cartridge 370. Seal 404 is positioned in at least one of distal or proximal ports 374 and 376, respectively, of cartridge 370. Cartridge transport device 372 moves each cartridge 370 to a position 405 that aligns penetrating member 312 with penetrating member driver 316 so that penetrating member 312 can be driven along a path into target tissue 320.

In another embodiment of the present invention as seen in FIG. 35, tissue penetrating system 310 includes a housing member 406, the plurality of penetrating members 312 positioned in housing member 406, and a tissue stabilizing member 408, which can also be a pressure applicator, stimulating member, stimulating vibratory member that imparts motion to a tissue surface, and the like. Tissue stabilizing member 408 can be positioned to at least partially surround an impact location of the penetrating member 312 on the target tissue 320 site. Tissue stabilizing member 408 can, enhance fluid flow from target tissue 320, stretch a target tissue 320 surface, apply a vacuum to target tissue 320, apply a force to target tissue 320 and cause target tissue 320 to press in an inward direction relative to housing member 406, apply a stimulation to target tissue 320, and the like. Tissue stabilizing member 408 can have a variety of different configurations. In one embodiment, tissue stabilizer member 408 includes a plurality of protrusions 410. In some further embodiments, a vacuum source 412 may be provided to assist the creation of a low pressure environment in the tissue stabilizing member 408 or along the fluid path to a sample chamber associated with the system 310. In some embodiments, the tissue stabilizing member 408 is mounted on the cartridge 370. In other embodiments, the member 408 may be mounted on the housing 406. The member 408 may also be pressed against the tissue site 320 and act as a pressure applicator. The member 408 may also be used against a variety of tissue including but not limited to skin or other body tissue.

Referring now to FIGS. 36 and 37, a cartridge 370 is shown with a penetrating member 312 creating a wound W in the tissue site 320. In FIG. 36, a movable capillary member 420 is extended towards the wound W as indicated by arrow 422 to gather body fluid being expressed from the wound. The fluid may be drawn to a sample chamber 384 (not shown). In FIG. 37, the wound W is created and then the entire cartridge is moved to the tissue site 320 to gather body fluid from the wound W. In some embodiments, the cartridge 370 moves towards the wound W relative to the housing 406.

Tissue penetrating systems 310 of FIGS. 22 through 37, can be utilized in a variety of different applications to detect any number of different analytes, including but not limited to glucose. The systems 310 may be used to measure potassium, other ions, or analytes associated with the process of glucose monitoring. The analyte detecting member 390 may further be adapted to measure other analytes found in body fluid.

In a still further embodiment, penetrating member 312 may be moved and positioned to be in engagement with penetrating member driver 316. Penetrating member 312 is in a sterile environment, and prior to launch, the sterilizing covering, which can be a seal is removed. Tissue stabilizing member can apply a stimulation to a surface of the target tissue 320 prior to, and during penetration by penetration member. Penetrating member 312 is engaged with penetrating driving member and controllably pierces a target tissue 320 site. Penetrating member sensor 324 is utilized to control penetration depth and velocity of penetrating member 312. Penetrating member 312 is stopped at a desired depth below a surface of target tissue 320 in order to reduce or eliminate without multiple oscillations against the surface of target tissue 320. A wound is created, causing blood to flow into sample chamber 384. In various embodiments, no more than 1 μL of a body fluid is collected in sample chamber 384.

A number of different preferences, options, embodiment, and features have been given above, and following any one of these may results in an embodiment of this invention that is more presently preferred than a embodiment in which that particular preference is not followed. These preferences, options, embodiment, and features may be generally independent, and additive; and following more than one of these preferences may result in a more presently preferred embodiment than one in which fewer of the preferences are followed.

While the invention has been described and illustrated with reference to certain particular embodiments thereof, those skilled in the art will appreciate that various adaptations, changes, modifications, substitutions, deletions, or additions of procedures and protocols may be made without departing from the spirit and scope of the invention. Any of the embodiments of the invention may be modified to include any of the features described above or feature incorporated by reference herein. For example, the cartridge of FIG. 26 may be adapted to include a distal portion with a tissue stabilizing member. The cartridge of FIG. 26 may be adapted for use with a vacuum device. The cartridge may include indexing features such as notches on the distal portion or outer radial periphery for those cartridges with a radial configuration. The notches will facilitate positioning, among other things, and may be used for movement. Other cartridges or tapes herein may be modified with notches or tractor holes to facilitate movement. User interfaces, human interfaces, and other interfaces may be added to any of the embodiments of the present invention.

With any of the above embodiments, the location of the penetrating member drive device may be varied, relative to the penetrating members or the cartridge. With any of the above embodiments, the penetrating member tips may be uncovered during actuation (i.e. penetrating members do not pierce the penetrating member enclosure or protective foil during launch). With any of the above embodiments, the penetrating members may be a bare penetrating member during launch. With any of the above embodiments, the penetrating members may be bare penetrating members prior to launch as this may allow for significantly tighter densities of penetrating members. In some embodiments, the penetrating members may be bent, curved, textured, shaped, or otherwise treated at a proximal end or area to facilitate handling by an actuator. The penetrating member may be configured to have a notch or groove to facilitate coupling to a gripper or coupler. The notch or groove may be formed along an elongate portion of the penetrating member. The coupler may be designed to create a frictional only type grip on the penetrating member.

With any of the above embodiments, any open cavity housing the penetrating may be on the bottom or the top of the cartridge, with the gripper on the other side. In some embodiments, sensors may be printed on the top, bottom, or side of the cavities. The front end of the cartridge maybe in contact with a user during lancing. The same driver may be used for advancing and retraction of the penetrating member. The penetrating member may have a diameters and length suitable for obtaining the blood volumes described herein. The penetrating member driver may also be in substantially the same plane as the cartridge. The driver may use a through hole or other opening to engage a proximal end of a penetrating member to actuate the penetrating member along a path into and out of the tissue.

Any of the features described in this application or any reference disclosed herein may be adapted for use with any embodiment of the present invention. For example, the devices of the present invention may also be combined for use with injection penetrating members or needles as described in commonly assigned, copending U.S. patent application Ser. No. 10/127,395 filed Apr. 19, 2002. A sensor to detect the presence of foil may also be included in the lancing apparatus. For example, if a cavity has been used before, the foil or sterility barrier will be punched. The sensor can detect if the cavity is fresh or not based on the status of the barrier. It should be understood that in optional embodiments, the sterility barrier may be designed to pierce a sterility barrier of thickness that does not dull a tip of the penetrating member. The lancing apparatus may also use improved drive mechanisms. For example, a solenoid force generator may be improved to try to increase the amount of force the solenoid can generate for a given current. A solenoid for use with the present invention may have five coils and in the present embodiment the slug is roughly the size of two coils. One change is to increase the thickness of the outer metal shell or windings surround the coils. By increasing the thickness, the flux will also be increased. The slug may be split; two smaller slugs may also be used and offset by ½ of a coil pitch. This allows more slugs to be approaching a coil where it could be accelerated. This creates more events where a slug is approaching a coil, creating a more efficient system.

In another optional alternative embodiment, a gripper in the inner end of the protective cavity may hold the penetrating member during shipment and after use, eliminating the feature of using the foil, protective end, or other part to retain the used penetrating member. Some other advantages of the disclosed embodiments and features of additional embodiments include: same mechanism for transferring the used penetrating members to a storage area; a high number of penetrating members such as 25, 50, 75, 100, 500, or more penetrating members may be put on a disk or cartridge; molded body about a penetrating member becomes unnecessary; manufacturing of multiple penetrating member devices is simplified through the use of cartridges; handling is possible of bare rods metal wires, without any additional structural features, to actuate them into tissue; maintaining extreme (better than 50 micron-lateral- and better than 20 micron vertical) precision in guiding; and storage system for new and used penetrating members, with individual cavities/slots is provided. The housing of the lancing device may also be sized to be ergonomically pleasing. In one embodiment, the device has a width of about 56 mm, a length of about 105 mm and a thickness of about 15 mm. Additionally, some embodiments of the present invention may be used with non-electrical force generators or drive mechanism. For example, the punch device and methods for releasing the penetrating members from sterile enclosures could be adapted for use with spring based launchers. The gripper using a frictional coupling may also be adapted for use with other drive technologies.

Still further optional features may be included with the present invention. For example, with any of the above embodiments, the location of the penetrating member drive device may be varied, relative to the penetrating members or the cartridge. With any of the above embodiments, the penetrating member tips may be uncovered during actuation (i.e. penetrating members do not pierce the penetrating member enclosure or protective foil during launch). The penetrating members may be a bare penetrating member during launch. The same driver may be used for advancing and retraction of the penetrating member. Different analyte detecting members detecting different ranges of glucose concentration, different analytes, or the like may be combined for use with each penetrating member. Non-potentiometric measurement techniques may also be used for analyte detection. For example, direct electron transfer of glucose oxidase molecules adsorbed onto carbon nanotube powder microelectrode may be used to measure glucose levels. In all methods, nanoscopic wire growth can be carried out via chemical vapor deposition (CVD). In all of the embodiments of the invention, preferred nanoscopic wires may be nanotubes. Any method useful for depositing a glucose oxidase or other analyte detection material on a nanowire or nanotube may be used with the present invention. Expected variations or differences in the results are contemplated in accordance with the objects and practices of the present invention. It is intended, therefore, that the invention be defined by the scope of the claims which follow and that such claims be interpreted as broadly as is reasonable.

Claims

1. A body fluid sampling system for use on a tissue site, the system comprising: a housing;an electrically powered drive force generator;a penetrating member operatively coupled to the electrically powered drive force generator, the electrically powered drive force generator moving the penetrating member along a path out of the housing having a penetrating member exit, into the tissue site, stopping in the tissue site, and withdrawing out of the tissue site following a predetermined velocity vs. position profile;a penetrating member sensor configured to monitor depth of penetration and velocity of the penetrating member;a processor coupled to the electrically powered drive force generator with program instructions that provide an input to the electrically powered drive force generator to control depth of penetration and velocity of the penetrating member to match the predetermined velocity vs. position profile via a feedback loop of the depth of penetration and velocity of the penetrating member from the penetrating member sensor; anda tissue stabilizing member associated with said housing and positioned to at least partially surround an impact location of the penetrating member on the tissue site wherein the tissue stabilizer member is configured to apply a force to a target tissue and cause the target tissue to press in an inward direction relative to the housing member.
2. The system of claim 1, wherein the penetrating member sensor includes an interference encoder.
3. The system of claim 1, further comprising an analyte detecting member.
4. The system of claim 1, further comprising a plurality of analyte detecting members positioned to receive body fluid.
5. The system of claim 1, further comprising: a sample chamber with an opening for transport of a body fluid into the sample chamber, the sample chamber being sized to receive no more than 1.0 μL of the body fluid.
6. The system of claim 1, further comprising: a sample chamber with an opening for transport of a body fluid into the sample chamber, the sample chamber being sized to receive no more than 0.75 μL of the body fluid.
7. The system of claim 1, further comprising: a sample chamber with an opening for transport of a body fluid into the sample chamber, the sample chamber being sized to receive no more than 0.5 μL of the body fluid.
8. The system of claim 1, further comprising: a sample chamber with an opening for transport of a body fluid into the sample chamber, the sample chamber being sized to receive no more than 0.25 μL of the body fluid.
9. The system of claim 1, further comprising: a sample chamber with an opening for transport of a body fluid into the sample chamber, the sample chamber being sized to receive no more than 0.1 μL of the body fluid.
10. The system of claim 1, further comprising: an analyte detecting member coupled to a sample chamber, the analyte detecting member being configured to determine a concentration of an analyte in a body fluid using a sample that does not exceed a volume of 1 μL of a body fluid disposed in the sample chamber.
11. The system of claim 1, further comprising: an analyte detecting member coupled to a sample chamber, the analyte detecting member being configured to determine a concentration of an analyte in a body fluid using a sample that does not exceed a volume of 0.75 μL of a body fluid disposed in the sample chamber.
12. The system of claim 1, further comprising: an analyte detecting member coupled to a sample chamber, the analyte detecting member being configured to determine a concentration of an analyte in a body fluid using a sample that does not exceed a volume of 0.5 μL of a body fluid disposed in the sample chamber.
13. The system of claim 1, further comprising: an analyte detecting member coupled to a sample chamber, the analyte detecting member being configured to determine a concentration of an analyte in a body fluid using a sample that does not exceed a volume of 0.25 μL of a body fluid disposed in the sample chamber.
14. The system of claim 1, further comprising: an analyte detecting member coupled to a sample chamber, the analyte detecting member being configured to determine a concentration of an analyte in a body fluid using a sample that does not exceed a volume of 0.1 μL of a body fluid disposed in the sample chamber.
15. The system of claim 1, wherein the penetrating member has a packing density of no more than 1.0 cm3/penetrating member.
16. The system of claim 1, wherein the penetrating member has a packing density of no more than 0.75 cm3/penetrating member.
17. The system of claim 1, wherein the the penetrating member has a packing density of no more than 0.5 cm3/penetrating member.
18. The system of claim 1, wherein the penetrating member has a packing density of no more than 0.25 cm3/penetrating member.
19. The system of claim 1, wherein the penetrating member has a packing density of no more than 0.1 cm3/penetrating member.
20. The system of claim 1, wherein the penetrating member and an associated sample chamber have a combined packing density of no more than 1.0 cm3.
21. The system of claim 1, wherein the penetrating member and an associated sample chamber have a combined packing density of no more than 0.75 cm3.
22. The system of claim 1, wherein the penetrating member and an associated sample chamber have a combined packing density of no more than 0.5 cm3.
23. The system of claim 1, wherein the penetrating member and an associated sample chamber have a combined packing density of no more than 0.25 cm3.
24. The system of claim 1, wherein the penetrating member and an associated sample chamber have a combined packing density of no more than 0.1 cm3.
25. The system of claim 1, wherein the tissue stabilizing member is configured to enhance fluid flow from a target tissue.
26. The system of claim 1, wherein the tissue stabilizing member creates a stretching of a skin surface.
27. The system of claim 1, wherein the tissue stabilizing member includes a plurality of protrusions.
28. The system of claim 1, wherein the tissue stabilizing member applies a vacuum to a target tissue.
29. The system of claim 1, wherein the tissue stabilizing member applies a stimulation to a target tissue.
30. The system of claim 1, further comprising: a seal formed by a fracturable material between the penetrating member and a cartridge, the seal being positioned at least one of a distal port or a proximal port of the cartridge.
31. The system of claim 30, further comprising a second fracturable seal located at least one of the distal port or proximal port of the cartridge.
32. The system of claim 1, wherein the penetrating member is an elongate member without molded attachments.
33. The system of claim 1, further comprising: a penetrating member transport device for moving the penetrating member into a position aligned with the driver.
34. The system of claim 1, further comprising, a belt for holding the penetrating member in an array configuration.
35. The system of claim 1, further comprising: a tape device configured to hold the penetrating member in an array configuration.
36. The system of claim 1, further comprising: a support channel configured to hold the penetrating member in an array configuration.
37. The system of claim 1, further comprising: a cog configured to hold the penetrating member in an array configuration.
38. The system of claim 1, further comprising: a plurality of connectors between a plurality of penetrating members for holding the penetrating members in an array configuration.
39. The system of claim 1, further comprising: a support structure for receiving the penetrating member.
40. The system of claim 39, wherein the support structure is a bandolier.
41. The system of claim 39, wherein the support structure is a drum.
42. A body fluid sampling system for use on a tissue site, the system comprising: an electrically powered drive force generator;a penetrating member operatively coupled to said electrically powered drive force generator, said electrically powered drive force generator moving said penetrating member along a path out of a housing having a penetrating member exit, into said tissue site, stopping in said tissue site, and withdrawing out of said tissue site following a predetermined velocity vs. position profile;a penetrating member sensor configured to monitor depth of penetration and velocity of the penetrating member;a processor coupled to the electrically powered drive force generator with program instructions that provide an input to the electrically powered drive force generator to control depth of penetration and velocity of the penetrating member to match the predetermined velocity vs. position profile via a feedback loop of the depth of penetration and velocity of the penetrating member from the penetrating member sensor; anda vacuum source associated with said system for creating a lower atmosphere environment to draw fluid from a wound created by said penetrating member.

CROSS-REFERENCE TO RELATED APPLICATION

This application is a divisional of U.S. Ser. No. 10/335,258 filed Dec. 31, 2002, now U.S. Pat. No. 7,674,232, which is a continuation-in-part of U.S. Ser. No. 10/127,395, filed Apr. 19, 2002, now U.S. Pat. No. 7,025,774). This application also claims the benefit of U.S. Ser. No. 10/237,261 filed Sep. 5, 2002, now U.S. Pat. No. 7,344,507. All applications listed above are fully incorporated herein by reference for all purposes.

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5512159	Yoshioka	Apr 1996	A
5514152	Smith	May 1996	A
5515170	Matzinger	May 1996	A
5518006	Mawhirt	May 1996	A
D371198	Savage	Jun 1996	S
5524636	Sarvazyan	Jun 1996	A
5525511	D'Costa	Jun 1996	A
5525518	Lundsgaard	Jun 1996	A
5526120	Jina	Jun 1996	A
5527333	Nikkels	Jun 1996	A
5527334	Kanner	Jun 1996	A
5529074	Greenfield	Jun 1996	A
5540676	Freiberg	Jul 1996	A
5540709	Ramel	Jul 1996	A
5543326	Heller	Aug 1996	A
5545174	Schenk	Aug 1996	A
5545291	Smith	Aug 1996	A
5547702	Gleisner	Aug 1996	A
D373419	Muramatsu	Sep 1996	S
5554153	Costello	Sep 1996	A
5554166	Lange	Sep 1996	A
5558834	Chu	Sep 1996	A
5562384	Alvite et al.	Oct 1996	A
5562696	Nobles	Oct 1996	A
5563031	Yu	Oct 1996	A
5563042	Phillips	Oct 1996	A
5569286	Peckham	Oct 1996	A
5569287	Tezuka	Oct 1996	A
5571132	Mawhirt	Nov 1996	A
5575284	Athan	Nov 1996	A
5575403	Charlton	Nov 1996	A
5575895	Ikeda	Nov 1996	A
5582697	Ikeda	Dec 1996	A
5584846	Mawhirt	Dec 1996	A
5591139	Lin	Jan 1997	A
5593852	Heller	Jan 1997	A
5599501	Carey	Feb 1997	A
5605837	Karimi	Feb 1997	A
D378612	Clark	Mar 1997	S
5608006	Myerson	Mar 1997	A
5609749	Yamauchi	Mar 1997	A
5611809	Marshall	Mar 1997	A
5611810	Arnold	Mar 1997	A
5613978	Harding	Mar 1997	A
5616135	Thorne	Apr 1997	A
5617851	Lipkovker	Apr 1997	A
5618297	Hart	Apr 1997	A
5620579	Genshaw	Apr 1997	A
5620863	Tomasco	Apr 1997	A
5624458	Lipscher	Apr 1997	A
5624459	Kortenbach	Apr 1997	A
5624537	Turner	Apr 1997	A
D379516	Rutter	May 1997	S
5628764	Schraga	May 1997	A
5628765	Morita	May 1997	A
5628890	Carter	May 1997	A
5628961	Davis	May 1997	A
5630828	Mawhirt	May 1997	A
5630986	Charlton	May 1997	A
5632410	Moulton	May 1997	A
5640954	Pfeiffer	Jun 1997	A
D381591	Rice	Jul 1997	S
5643306	Schraga	Jul 1997	A
5643308	Markman	Jul 1997	A
5645555	Davis	Jul 1997	A
5647851	Pokras	Jul 1997	A
5650062	Ikeda	Jul 1997	A
5653863	Genshaw	Aug 1997	A
5657760	Ying et al.	Aug 1997	A
5658444	Black	Aug 1997	A
5660791	Brenneman	Aug 1997	A
D383550	Larson	Sep 1997	S
5662127	De Vaughn	Sep 1997	A
5662672	Pambianchi	Sep 1997	A
5666966	Horie	Sep 1997	A
5676143	Simonsen	Oct 1997	A
5678306	Bozeman	Oct 1997	A
5680858	Hansen	Oct 1997	A
5680872	Sesekura	Oct 1997	A
5682233	Brinda	Oct 1997	A
5682884	Hill	Nov 1997	A
5683562	Schaffar	Nov 1997	A
5691898	Rosenberg	Nov 1997	A
5692514	Bowman	Dec 1997	A
5695947	Guo	Dec 1997	A
5700695	Yassinzadeh	Dec 1997	A
5705045	Park	Jan 1998	A
5707384	Kim	Jan 1998	A
5708247	McAleer	Jan 1998	A
5709668	Wacks	Jan 1998	A
5709699	Warner	Jan 1998	A
5710011	Forrow	Jan 1998	A
5714123	Sohrab	Feb 1998	A
5714390	Hallowitz	Feb 1998	A
5719034	Kiser	Feb 1998	A
5720862	Hamamoto	Feb 1998	A
5720924	Eikmeier	Feb 1998	A
D392391	Douglas	Mar 1998	S
D392740	Yung	Mar 1998	S
5723284	Ye	Mar 1998	A
5727548	Hill	Mar 1998	A
5729905	Mathiasmeier	Mar 1998	A
5730753	Morita	Mar 1998	A
5733085	Shida	Mar 1998	A
5733300	Pambianchi	Mar 1998	A
D393716	Brenneman	Apr 1998	S
D393717	Brenneman	Apr 1998	S
5735868	Lee	Apr 1998	A
5736103	Pugh	Apr 1998	A
5738244	Charlton et al.	Apr 1998	A
5741228	Lambrecht	Apr 1998	A
5741634	Nozoe	Apr 1998	A
RE35803	Lange	May 1998	E
5746217	Erickson	May 1998	A
5746761	Turchin	May 1998	A
5746898	Preidel	May 1998	A
5753429	Pugh	May 1998	A
5753452	Smith	May 1998	A
5755228	Wilson	May 1998	A
5755733	Morita	May 1998	A
5758643	Wong	Jun 1998	A
5759364	Charlton	Jun 1998	A
5762770	Pritchard	Jun 1998	A
5770086	Indriksons et al.	Jun 1998	A
5770369	Meade	Jun 1998	A
5772586	Heinonen	Jun 1998	A
5772677	Mawhirt	Jun 1998	A
5773270	D'Orazio	Jun 1998	A
5776157	Thorne	Jul 1998	A
5776719	Douglas	Jul 1998	A
5779365	Takaki	Jul 1998	A
5780304	Matzinger	Jul 1998	A
5782770	Mooradian	Jul 1998	A
5782852	Foggia	Jul 1998	A
5788651	Weilandt	Aug 1998	A
5788652	Rahn	Aug 1998	A
5789255	Yu	Aug 1998	A
5794219	Brown	Aug 1998	A
5795725	Buechler	Aug 1998	A
5795774	Matsumoto	Aug 1998	A
5797940	Mawhirt	Aug 1998	A
5797942	Schraga	Aug 1998	A
5798030	Raguse	Aug 1998	A
5798031	Charlton	Aug 1998	A
5800781	Gavin	Sep 1998	A
5801057	Smart	Sep 1998	A
5807375	Gross	Sep 1998	A
5810199	Charlton	Sep 1998	A
D399566	Sohrab	Oct 1998	S
5820551	Hill	Oct 1998	A
5822715	Worthington	Oct 1998	A
5823973	Racchini	Oct 1998	A
5824491	Priest	Oct 1998	A
5827181	Dias	Oct 1998	A
5828943	Brown	Oct 1998	A
5829589	Nguyen	Nov 1998	A
5830219	Bird et al.	Nov 1998	A
5832448	Brown	Nov 1998	A
5840020	Heinonen	Nov 1998	A
5840171	Birch	Nov 1998	A
5843691	Douglas	Dec 1998	A
5843692	Phillips	Dec 1998	A
5846216	Gonzales	Dec 1998	A
5846486	Pugh	Dec 1998	A
5846490	Yokota	Dec 1998	A
5849174	Sanghera	Dec 1998	A
5853373	Griffith	Dec 1998	A
5854074	Charlton	Dec 1998	A
D403975	Douglas	Jan 1999	S
5855377	Murphy	Jan 1999	A
5855801	Lin	Jan 1999	A
5856174	Lipshutz	Jan 1999	A
5856195	Charlton	Jan 1999	A
5857967	Frid	Jan 1999	A
5857983	Douglas	Jan 1999	A
5858804	Zanzucchi	Jan 1999	A
5860922	Gordon et al.	Jan 1999	A
5863800	Eikmeier	Jan 1999	A
5866353	Berneth	Feb 1999	A
5868135	Kaufman	Feb 1999	A
5868772	LeVaughn	Feb 1999	A
5869972	Birch	Feb 1999	A
5871494	Simons et al.	Feb 1999	A
5872713	Douglas	Feb 1999	A
5873887	King	Feb 1999	A
5876351	Rohde	Mar 1999	A
5876957	Douglas	Mar 1999	A
5879163	Brown	Mar 1999	A
5879310	Sopp	Mar 1999	A
5879311	Duchon	Mar 1999	A
5879373	Roper	Mar 1999	A
5880829	Kauhaniemi	Mar 1999	A
5882494	van Antwerp	Mar 1999	A
5885211	Eppstein	Mar 1999	A
5886056	Hershkowitz	Mar 1999	A
5887133	Brown	Mar 1999	A
5890128	Diaz	Mar 1999	A
RE36191	Solomon	Apr 1999	E
5891053	Sesekura	Apr 1999	A
5893848	Negus	Apr 1999	A
5893870	Talen	Apr 1999	A
5897493	Brown	Apr 1999	A
5897569	Kellogg	Apr 1999	A
5899855	Brown	May 1999	A
5899915	Saadat	May 1999	A
5900130	Benvegnu	May 1999	A
5902731	Ouyang	May 1999	A
5906921	Ikeda	May 1999	A
D411619	Duchon	Jun 1999	S
5908416	Costello	Jun 1999	A
5911937	Hekal	Jun 1999	A
5912134	Shartle	Jun 1999	A
5913310	Brown	Jun 1999	A
5916156	Hildenbrand	Jun 1999	A
5916229	Evans	Jun 1999	A
5916230	Brenneman	Jun 1999	A
5918603	Brown	Jul 1999	A
5919711	Boyd	Jul 1999	A
5921963	Erez	Jul 1999	A
5922188	Ikeda	Jul 1999	A
5922530	Yu	Jul 1999	A
5922591	Anderson	Jul 1999	A
RE36268	Szuminsky	Aug 1999	E
5931794	Pitesky	Aug 1999	A
5933136	Brown	Aug 1999	A
5935075	Casscells et al.	Aug 1999	A
5938635	Kuhle	Aug 1999	A
5938679	Freeman	Aug 1999	A
5940153	Castaneda	Aug 1999	A
5942102	Hodges	Aug 1999	A
5942189	Wolfbeis	Aug 1999	A
5947957	Morris	Sep 1999	A
5951300	Brown	Sep 1999	A
5951492	Douglas	Sep 1999	A
5951493	Douglas et al.	Sep 1999	A
5951582	Thorne	Sep 1999	A
5951836	McAleer	Sep 1999	A
5954738	LeVaughn	Sep 1999	A
5956501	Brown	Sep 1999	A
5957846	Chiang	Sep 1999	A
5958199	Miyamoto	Sep 1999	A
5959098	Goldberg	Sep 1999	A
5960403	Brown	Sep 1999	A
5961451	Reber	Oct 1999	A
5964718	Duchon	Oct 1999	A
5965380	Heller	Oct 1999	A
5968063	Chu	Oct 1999	A
5968760	Phillips	Oct 1999	A
5968836	Matzinger	Oct 1999	A
5971941	Simons et al.	Oct 1999	A
5972199	Heller	Oct 1999	A
5972294	Smith	Oct 1999	A
5972715	Celentano	Oct 1999	A
5974124	Schlueter	Oct 1999	A
5976085	Kimball	Nov 1999	A
5983193	Heinonen	Nov 1999	A
5985116	Ikeda	Nov 1999	A
5985559	Brown	Nov 1999	A
5986754	Harding	Nov 1999	A
5993400	Rincoe	Nov 1999	A
5993434	Dev	Nov 1999	A
D417504	Love	Dec 1999	S
5997476	Brown	Dec 1999	A
5997561	Bocker	Dec 1999	A
5997817	Crismore	Dec 1999	A
5997818	Hacker	Dec 1999	A
6001067	Shults	Dec 1999	A
6007497	Huitema	Dec 1999	A
D418602	Prokop	Jan 2000	S
6014577	Henning	Jan 2000	A
6015392	Douglas	Jan 2000	A
6018289	Sekura	Jan 2000	A
6020110	Williams	Feb 2000	A
6022324	Skinner	Feb 2000	A
6022366	Schraga	Feb 2000	A
6022748	Charych	Feb 2000	A
6023629	Tamada	Feb 2000	A
6023686	Brown	Feb 2000	A
6027459	Shain	Feb 2000	A
6030399	Ignotz	Feb 2000	A
6030827	Davis	Feb 2000	A
6030967	Marui	Feb 2000	A
6032059	Henning	Feb 2000	A
6032119	Brown	Feb 2000	A
6033421	Theiss	Mar 2000	A
6033866	Guo	Mar 2000	A
6036924	Simons	Mar 2000	A
6037178	Leiner	Mar 2000	A
6041253	Kost	Mar 2000	A
6045567	Taylor	Apr 2000	A
6046055	Wolfbeis	Apr 2000	A
6048352	Douglas	Apr 2000	A
D424696	Ray	May 2000	S
6056701	Duchon	May 2000	A
6059815	Lee	May 2000	A
6060327	Keen	May 2000	A
6061128	Zweig	May 2000	A
6063039	Cunningham	May 2000	A
6066103	Duchon	May 2000	A
6066243	Anderson	May 2000	A
6066296	Brady	May 2000	A
6067463	Jeng	May 2000	A
6068615	Brown	May 2000	A
D426638	Ray	Jun 2000	S
6070761	Bloom	Jun 2000	A
6071249	Cunningham	Jun 2000	A
6071250	Douglas	Jun 2000	A
6071251	Cunningham et al.	Jun 2000	A
6071294	Simons	Jun 2000	A
6071391	Gotoh	Jun 2000	A
6074360	Haar et al.	Jun 2000	A
6077408	Miyamoto	Jun 2000	A
6080106	Lloyd	Jun 2000	A
6080172	Fujiwara	Jun 2000	A
D428150	Ruf	Jul 2000	S
6083196	Trautman	Jul 2000	A
6083710	Heller	Jul 2000	A
6084660	Shartle	Jul 2000	A
6085576	Sunshine	Jul 2000	A
6086544	Hibner	Jul 2000	A
6086545	Roe	Jul 2000	A
6086562	Jacobsen	Jul 2000	A
6090078	Erskine	Jul 2000	A
6091975	Daddona	Jul 2000	A
6093146	Filangeri	Jul 2000	A
6093156	Cunningham	Jul 2000	A
D428993	Lubs	Aug 2000	S
6099484	Douglas	Aug 2000	A
6099802	Pugh	Aug 2000	A
6100107	Lei	Aug 2000	A
6101478	Brown	Aug 2000	A
6102933	Lee	Aug 2000	A
6103033	Say	Aug 2000	A
6103509	Sode	Aug 2000	A
6104940	Watanabe	Aug 2000	A
6106751	Talbot	Aug 2000	A
6107083	Collins	Aug 2000	A
6113578	Brown	Sep 2000	A
6117630	Reber	Sep 2000	A
6118126	Zanzucchi	Sep 2000	A
6119033	Spigelman	Sep 2000	A
6120462	Hibner	Sep 2000	A
6120676	Heller	Sep 2000	A
6121009	Heller	Sep 2000	A
6122536	Sun	Sep 2000	A
6126804	Andresen	Oct 2000	A
6126899	Woudenberg	Oct 2000	A
6129823	Hughes	Oct 2000	A
6132449	Lum	Oct 2000	A
6133837	Riley	Oct 2000	A
6134461	Say	Oct 2000	A
6136013	Marshall	Oct 2000	A
6139562	Mauze	Oct 2000	A
6143164	Heller	Nov 2000	A
6144837	Quy	Nov 2000	A
6149203	Hanlon	Nov 2000	A
6151586	Brown	Nov 2000	A
6152875	Hakamata	Nov 2000	A
6152942	Brenneman	Nov 2000	A
6153069	Pottgen	Nov 2000	A
RE36991	Yamamoto	Dec 2000	E
6155267	Nelson	Dec 2000	A
6155992	Henning	Dec 2000	A
6156051	Schraga	Dec 2000	A
6157442	Raskas	Dec 2000	A
6159147	Lichter	Dec 2000	A
6159424	Kauhaniemi	Dec 2000	A
6161095	Brown	Dec 2000	A
6162397	Jurik	Dec 2000	A
6162611	Heller	Dec 2000	A
6167362	Brown	Dec 2000	A
6167386	Brown	Dec 2000	A
6168563	Brown	Jan 2001	B1
6168957	Matzinger	Jan 2001	B1
6171325	Mauze et al.	Jan 2001	B1
6172743	Kley et al.	Jan 2001	B1
6175752	Say	Jan 2001	B1
6176847	Humphreys	Jan 2001	B1
6176865	Mauze	Jan 2001	B1
6177000	Peterson	Jan 2001	B1
6177931	Alexander et al.	Jan 2001	B1
6183489	Douglas	Feb 2001	B1
6186145	Brown	Feb 2001	B1
6190612	Berger	Feb 2001	B1
6191852	Paffhausen	Feb 2001	B1
6192891	Gravel	Feb 2001	B1
6193673	Viola	Feb 2001	B1
6193873	Ohara	Feb 2001	B1
6194900	Freeman	Feb 2001	B1
6197040	LeVaughn	Mar 2001	B1
6197257	Raskas	Mar 2001	B1
6200773	Ouyang	Mar 2001	B1
6203504	Latterell	Mar 2001	B1
6206841	Cunningham et al.	Mar 2001	B1
6210133	Aboul-Hosn	Apr 2001	B1
6210272	Brown	Apr 2001	B1
6210369	Wilmot	Apr 2001	B1
6210420	Mauze	Apr 2001	B1
6210421	Bocker	Apr 2001	B1
6212417	Ikeda	Apr 2001	B1
6214626	Meller	Apr 2001	B1
6214804	Felgner	Apr 2001	B1
6218571	Zheng	Apr 2001	B1
6219574	Cormier	Apr 2001	B1
6221023	Matsuba	Apr 2001	B1
6221238	Grundig	Apr 2001	B1
6225078	Ikeda	May 2001	B1
6228100	Schraga	May 2001	B1
6230051	Cormier	May 2001	B1
6230501	Bailey	May 2001	B1
6231531	Lum	May 2001	B1
6233471	Berner	May 2001	B1
6233539	Brown	May 2001	B1
6234772	Wampler	May 2001	B1
6240393	Brown	May 2001	B1
D444235	Roberts	Jun 2001	S
6241862	McAleer	Jun 2001	B1
6242207	Douglas	Jun 2001	B1
6245060	Loomis	Jun 2001	B1
6245215	Douglas	Jun 2001	B1
6246992	Brown	Jun 2001	B1
6248065	Brown	Jun 2001	B1
6251083	Yum	Jun 2001	B1
6251121	Saadat	Jun 2001	B1
6251260	Heller	Jun 2001	B1
6251344	Goldstein	Jun 2001	B1
D444557	Levaughn	Jul 2001	S
6254831	Barnard	Jul 2001	B1
6256533	Vuzhakov	Jul 2001	B1
6258111	Ross	Jul 2001	B1
6258229	Winarta	Jul 2001	B1
6258254	Miyamoto	Jul 2001	B1
6261241	Burbank	Jul 2001	B1
6261245	Kawai	Jul 2001	B1
6261519	Harding	Jul 2001	B1
6264635	Wampler	Jul 2001	B1
6268161	Han	Jul 2001	B1
6268162	Phillips	Jul 2001	B1
6269314	Iitawaki	Jul 2001	B1
6270455	Brown	Aug 2001	B1
6270637	Crismore	Aug 2001	B1
6272359	Kivela	Aug 2001	B1
6272364	Kurnik	Aug 2001	B1
6275717	Gross	Aug 2001	B1
6280254	Wu	Aug 2001	B1
6281006	Heller	Aug 2001	B1
6283926	Cunningham	Sep 2001	B1
6283982	Levaughn	Sep 2001	B1
6284478	Heller	Sep 2001	B1
6285448	Kuenstner	Sep 2001	B1
6285454	Douglas	Sep 2001	B1
6289254	Shimizu	Sep 2001	B1
6290683	Erez	Sep 2001	B1
6294897	Champlin	Sep 2001	B1
6295506	Heinonen	Sep 2001	B1
6299578	Kurnik	Oct 2001	B1
6299596	Ding	Oct 2001	B1
6299757	Feldman	Oct 2001	B1
6302844	Walker	Oct 2001	B1
6302855	Lav	Oct 2001	B1
6305804	Rice	Oct 2001	B1
6306104	Cunningham	Oct 2001	B1
6306152	Verdonk	Oct 2001	B1
6306347	Mason	Oct 2001	B1
6309351	Kurnik	Oct 2001	B1
6309535	Williams	Oct 2001	B1
6312612	Sherman	Nov 2001	B1
6315738	Nishikawa	Nov 2001	B1
6318970	Backhouse	Nov 2001	B1
6319210	Douglas	Nov 2001	B1
6322574	Lloyd	Nov 2001	B1
6322808	Trautman	Nov 2001	B1
6322963	Bauer	Nov 2001	B1
6329161	Heller	Dec 2001	B1
6330426	Brown	Dec 2001	B2
6331163	Kaplan	Dec 2001	B1
6332871	Douglas	Dec 2001	B1
6334363	Testud	Jan 2002	B1
6334778	Brown	Jan 2002	B1
6334856	Allen	Jan 2002	B1
6335203	Patel	Jan 2002	B1
6336900	Alleckson	Jan 2002	B1
6338790	Feldman	Jan 2002	B1
6346120	Yamazaki	Feb 2002	B1
6349229	Watanabe	Feb 2002	B1
6350273	Minagawa	Feb 2002	B1
6350451	Horn	Feb 2002	B1
6352514	Douglas	Mar 2002	B1
6352523	Brown	Mar 2002	B1
6353753	Flock	Mar 2002	B1
6364889	Kheiri et al.	Apr 2002	B1
6364890	Lum	Apr 2002	B1
6368273	Brown	Apr 2002	B1
6375469	Brown	Apr 2002	B1
6375627	Mauze	Apr 2002	B1
6379301	Worthington	Apr 2002	B1
6379317	Kintzig	Apr 2002	B1
6379324	Gartstein	Apr 2002	B1
6379969	Mauze	Apr 2002	B1
6381577	Brown	Apr 2002	B1
D456910	Clark	May 2002	S
6387709	Mason	May 2002	B1
6391005	Lum	May 2002	B1
6395227	Kiser	May 2002	B1
6398522	Skill	Jun 2002	B2
6398562	Butler	Jun 2002	B1
6399394	Dahm	Jun 2002	B1
6402701	Kaplan	Jun 2002	B1
6402704	Mcmorrow	Jun 2002	B1
6409740	Kuhr	Jun 2002	B1
6413410	Hodges	Jul 2002	B1
6413411	Pottgen	Jul 2002	B1
6415821	Kamholz	Jul 2002	B2
6420128	Ouyang	Jul 2002	B1
6421633	Heinonen	Jul 2002	B1
6423014	Churchill et al.	Jul 2002	B1
6428664	Bhullar	Aug 2002	B1
6436055	Roe	Aug 2002	B1
6436256	Williams	Aug 2002	B1
6436721	Kuo	Aug 2002	B1
6440645	Yon-Hin	Aug 2002	B1
6444115	Hodges	Sep 2002	B1
6447265	Antaki	Sep 2002	B1
6451040	Purcell	Sep 2002	B1
6453810	Rossmeisl	Sep 2002	B1
6458258	Taniike	Oct 2002	B2
6461496	Feldman	Oct 2002	B1
6462162	Van Antwerp	Oct 2002	B2
6464649	Duchon	Oct 2002	B1
6471903	Sherman	Oct 2002	B2
6472220	Simons	Oct 2002	B1
6475360	Hodges	Nov 2002	B1
6475372	Ohara	Nov 2002	B1
6475436	Schabbach	Nov 2002	B1
6475750	Han et al.	Nov 2002	B1
6477394	Rice	Nov 2002	B2
6477424	Thompson	Nov 2002	B1
6484046	Say	Nov 2002	B1
6485439	Roe	Nov 2002	B1
6485461	Mason	Nov 2002	B1
6485923	Yani	Nov 2002	B1
6488827	Shartle	Dec 2002	B1
6488891	Mason	Dec 2002	B2
6489133	Phillips	Dec 2002	B2
6491709	Sharma	Dec 2002	B2
6491870	Patel	Dec 2002	B2
6494830	Wessel	Dec 2002	B1
6497845	Sacherer	Dec 2002	B1
6501404	Walker	Dec 2002	B2
6501976	Sohrab	Dec 2002	B1
6503209	Hakky et al.	Jan 2003	B2
6503210	Hirao	Jan 2003	B1
6503231	Prausnitz	Jan 2003	B1
6503290	Jarosinski	Jan 2003	B1
6503381	Gotoh	Jan 2003	B1
6506165	Sweeney	Jan 2003	B1
6506168	Fathallah	Jan 2003	B1
6506575	Knappe	Jan 2003	B1
6508785	Eppstein	Jan 2003	B1
6512986	Harmon	Jan 2003	B1
6514270	Schraga	Feb 2003	B1
6514460	Fendrock	Feb 2003	B1
6519241	Theimer	Feb 2003	B1
6520326	McIvor	Feb 2003	B2
6521110	Hodges	Feb 2003	B1
6521182	Shartle	Feb 2003	B1
6527521	Noda	Mar 2003	B2
6527716	Epstein	Mar 2003	B1
6527778	Athanasiou	Mar 2003	B2
6529377	Nelson et al.	Mar 2003	B1
6530892	Kelly	Mar 2003	B1
6530937	Schraga	Mar 2003	B1
6531322	Jurik	Mar 2003	B1
6533949	Yeshurun	Mar 2003	B1
6537207	Rice	Mar 2003	B1
6537242	Palmer	Mar 2003	B1
6537264	Cormier et al.	Mar 2003	B1
6537292	Lee	Mar 2003	B1
6540672	Simonsen	Apr 2003	B1
6540675	Aceti	Apr 2003	B2
6540762	Bertling	Apr 2003	B1
6540891	Stewart	Apr 2003	B1
6541266	Modzelewski	Apr 2003	B2
6547954	Ikeda	Apr 2003	B2
6549796	Sohrab	Apr 2003	B2
6551494	Feldman	Apr 2003	B1
6553244	Lesho	Apr 2003	B2
6554381	Locher	Apr 2003	B2
6555061	Leong	Apr 2003	B1
D475136	Taniguchi	May 2003	S
6558320	Causey	May 2003	B1
6558361	Yeshurun	May 2003	B1
6558402	Chelak	May 2003	B1
6558528	Matzinger	May 2003	B1
6560471	Heller	May 2003	B1
6561978	Conn	May 2003	B1
6561989	Whitson	May 2003	B2
6562210	Bhullar	May 2003	B1
6565509	Say et al.	May 2003	B1
6565808	Hudak	May 2003	B2
6569157	Shain	May 2003	B1
6571651	Hodges	Jun 2003	B1
6572566	Effenhauser	Jun 2003	B2
6572822	Jurik	Jun 2003	B2
6574490	Abblnk	Jun 2003	B2
6575905	Knobbe	Jun 2003	B2
6576101	Heller	Jun 2003	B1
6576117	Iketaki et al.	Jun 2003	B1
6576416	Haviland	Jun 2003	B2
6579690	Bonnecaze	Jun 2003	B1
6582573	Douglas	Jun 2003	B2
6584338	Van Muiswinkel	Jun 2003	B1
D477670	Jurik	Jul 2003	S
6586199	Ouyang	Jul 2003	B2
6587705	Kim et al.	Jul 2003	B1
6589260	Schmelzeisen-R	Jul 2003	B1
6589261	Abulhaj	Jul 2003	B1
6591124	Sherman	Jul 2003	B2
6591125	Buse	Jul 2003	B1
6592744	Hodges	Jul 2003	B1
6592745	Feldman	Jul 2003	B1
6595919	Berner	Jul 2003	B2
6599407	Taniike	Jul 2003	B2
6599693	Webb	Jul 2003	B1
6599769	Kondo	Jul 2003	B2
6601534	Hebrank	Aug 2003	B2
6602205	Erickson	Aug 2003	B1
6602268	Kuhr	Aug 2003	B2
6602678	Kwon	Aug 2003	B2
6604050	Trippel	Aug 2003	B2
6607362	Lum	Aug 2003	B2
6607494	Fowler	Aug 2003	B1
6607658	Heller	Aug 2003	B1
6612111	Hodges	Sep 2003	B1
6616616	Fritz	Sep 2003	B2
6616819	Liamos	Sep 2003	B1
6618934	Feldman	Sep 2003	B1
6620112	Klitmose	Sep 2003	B2
6620310	Ohara	Sep 2003	B1
6623501	Heller	Sep 2003	B2
6626851	Hirao	Sep 2003	B2
6632349	Hodges	Oct 2003	B1
6635222	Kent	Oct 2003	B2
6638415	Hodges	Oct 2003	B1
6638772	Douglas	Oct 2003	B1
6641533	Causey	Nov 2003	B2
6645142	Braig	Nov 2003	B2
6645219	Roe	Nov 2003	B2
6645368	Beatty	Nov 2003	B1
6649416	Kauer	Nov 2003	B1
6650915	Routt	Nov 2003	B2
6652720	Mansouri	Nov 2003	B1
6652734	Hodges	Nov 2003	B1
6652814	House	Nov 2003	B1
D484600	Kaar	Dec 2003	S
6656697	Ouyang	Dec 2003	B1
6656702	Yugawa	Dec 2003	B1
6659966	Essenpreis	Dec 2003	B2
6660018	Lum	Dec 2003	B2
6662439	Bhullar	Dec 2003	B1
6669669	Flaherty	Dec 2003	B2
6671527	Peterson	Dec 2003	B2
D484980	Hartwein	Jan 2004	S
6673617	Patel	Jan 2004	B2
6676995	Dick	Jan 2004	B2
6679841	Bojan	Jan 2004	B2
6679852	Schmelzeisen-Redeker et al.	Jan 2004	B1
6682933	Patel	Jan 2004	B2
6689411	Dick	Feb 2004	B2
6706000	Perez	Mar 2004	B2
6706049	Moerman	Mar 2004	B2
6706159	Moerman	Mar 2004	B2
6706232	Hasegawa	Mar 2004	B2
6709692	Sudor	Mar 2004	B2
6713660	Roe	Mar 2004	B1
6716577	Yu	Apr 2004	B1
6719887	Hasegawa	Apr 2004	B2
6719923	Stiene	Apr 2004	B2
6721586	Kiser	Apr 2004	B2
6723046	Lichtenstein	Apr 2004	B2
6723111	Abulhaj	Apr 2004	B2
6723371	Chih-hui	Apr 2004	B2
6723500	Yu	Apr 2004	B2
6726818	Cui et al.	Apr 2004	B2
6730494	Toranto	May 2004	B1
6731966	Spigelman	May 2004	B1
6733493	Gruzdev	May 2004	B2
6736777	Kim	May 2004	B2
6738654	Sohrab	May 2004	B2
6740215	Nakaminami et al.	May 2004	B1
6743211	Prausnitz	Jun 2004	B1
6743597	Guo	Jun 2004	B1
6743635	Neel	Jun 2004	B2
6746872	Zheng	Jun 2004	B2
6749618	Levaughn	Jun 2004	B2
6749740	Liamos et al.	Jun 2004	B2
6749792	Olsen	Jun 2004	B2
6749887	Dick	Jun 2004	B1
6751491	Lew	Jun 2004	B2
6752817	Flora	Jun 2004	B2
6753187	Cizdziel	Jun 2004	B2
6759190	Lin	Jul 2004	B2
6764496	Schraga	Jul 2004	B2
6764581	Forrow	Jul 2004	B1
6767441	Cai	Jul 2004	B1
6773671	Lewis	Aug 2004	B1
6776888	Yamamoto	Aug 2004	B2
6780645	Hayter	Aug 2004	B2
6780647	Fujiwara	Aug 2004	B2
6783502	Orloff	Aug 2004	B2
6783537	Kuhr	Aug 2004	B1
6784274	van Antwerp	Aug 2004	B2
6786874	Grace	Sep 2004	B2
6787013	Chang	Sep 2004	B2
6787109	Haar	Sep 2004	B2
6790327	Nankai	Sep 2004	B2
6790599	Madou	Sep 2004	B1
6792791	Sato	Sep 2004	B2
6793632	Sohrab	Sep 2004	B2
6793633	Douglas	Sep 2004	B2
6793802	Lee	Sep 2004	B2
6797150	Kermani	Sep 2004	B2
6800488	Khan	Oct 2004	B2
6801041	Karinka	Oct 2004	B2
6801804	Miller	Oct 2004	B2
6802199	Hilgers	Oct 2004	B2
6802811	Slepian	Oct 2004	B1
6802957	Jung	Oct 2004	B2
6805780	Ryu	Oct 2004	B1
6808499	Churchill	Oct 2004	B1
6808908	Yao	Oct 2004	B2
6808937	Ligler	Oct 2004	B2
6809807	Erickson	Oct 2004	B1
6811406	Grubge	Nov 2004	B2
6811557	Schraga	Nov 2004	B2
6811659	Vachon	Nov 2004	B2
6811753	Hirao	Nov 2004	B2
6811792	Roser	Nov 2004	B2
6812031	Carlsson	Nov 2004	B1
6814843	Bhullar	Nov 2004	B1
6814844	Bhullar	Nov 2004	B2
6814845	Wilson	Nov 2004	B2
6815186	Clark	Nov 2004	B2
6816742	Kim	Nov 2004	B2
6818180	Douglas	Nov 2004	B2
6821483	Phillips et al.	Nov 2004	B2
6823750	Hodges	Nov 2004	B2
6825047	Woudenberg	Nov 2004	B1
6827250	Uhland	Dec 2004	B2
6827829	Kawanaka	Dec 2004	B2
6829507	Lidman	Dec 2004	B1
6830551	Uchigaki	Dec 2004	B1
6830668	Musho	Dec 2004	B2
6830669	Miyazaki	Dec 2004	B2
6830934	Hardling	Dec 2004	B1
6833540	MacKenzie	Dec 2004	B2
6835184	Sage	Dec 2004	B1
6835553	Han	Dec 2004	B2
6835570	Patel	Dec 2004	B2
6837858	Cunningham	Jan 2005	B2
6837976	Cai	Jan 2005	B2
6837988	Leong	Jan 2005	B2
6840912	Kloepfer	Jan 2005	B2
6841052	Musho	Jan 2005	B2
6843254	Tapper	Jan 2005	B2
6843902	Penner	Jan 2005	B1
6847451	Pugh	Jan 2005	B2
6849052	Uchigaki et al.	Feb 2005	B2
6849168	Crumly et al.	Feb 2005	B2
6849216	Rappin	Feb 2005	B2
6849456	Patel	Feb 2005	B2
6850790	Berner	Feb 2005	B2
6852119	Abulhaj	Feb 2005	B1
6852212	Maxwell	Feb 2005	B2
6852500	Hoss	Feb 2005	B1
6853854	Proniewiez	Feb 2005	B1
6855243	Khan	Feb 2005	B2
6856125	Kermani	Feb 2005	B2
6856928	Harmon	Feb 2005	B2
6858015	List	Feb 2005	B2
6858401	Phillips	Feb 2005	B2
6859738	Bush	Feb 2005	B2
6862466	Ackerman	Mar 2005	B2
6862534	Sterling	Mar 2005	B2
6863800	Karinka	Mar 2005	B2
6863801	Hodges	Mar 2005	B2
6865408	Abbink	Mar 2005	B1
6866641	Marshall	Mar 2005	B2
6866675	Perez	Mar 2005	B2
6866758	Bhullar	Mar 2005	B2
6866822	House	Mar 2005	B1
6869418	Marano-Ford	Mar 2005	B2
6872200	Mann	Mar 2005	B2
6872297	Mansouri	Mar 2005	B2
6872298	Kermani	Mar 2005	B2
6872299	Kermani	Mar 2005	B2
6872358	Hagen	Mar 2005	B2
6875208	Santini	Apr 2005	B2
6875223	Argauer	Apr 2005	B2
6875327	Miyazaki	Apr 2005	B1
6875613	Shartle	Apr 2005	B2
6878120	Roe	Apr 2005	B2
6878251	Hodges	Apr 2005	B2
6878255	Wang	Apr 2005	B1
6878262	Taniike	Apr 2005	B2
6880968	Haar	Apr 2005	B1
6881203	Delmore	Apr 2005	B2
6881322	Tokunaga	Apr 2005	B2
6881378	Zimmer	Apr 2005	B1
6881541	Petersen et al.	Apr 2005	B2
6881550	Phillips	Apr 2005	B2
6881551	Heller	Apr 2005	B2
6881578	Otake	Apr 2005	B2
6882940	Potts	Apr 2005	B2
6884592	Matzinger	Apr 2005	B2
6885196	Taniike	Apr 2005	B2
6885883	Parris	Apr 2005	B2
6887202	Currie	May 2005	B2
6887239	Elstrom	May 2005	B2
6887253	Schraga	May 2005	B2
6887254	Curie	May 2005	B1
6887426	Phillips	May 2005	B2
6887709	Leong	May 2005	B2
6889069	Routt	May 2005	B2
6890319	Crocker	May 2005	B1
6890421	Ohara	May 2005	B2
6890484	Bautista	May 2005	B2
6891936	Kai	May 2005	B2
6892085	McIvor	May 2005	B2
6893396	Schulze	May 2005	B2
6893545	Gotoh	May 2005	B2
6893552	Wang	May 2005	B1
6895263	Shin	May 2005	B2
6895264	Rice	May 2005	B2
6895265	Silver	May 2005	B2
6896793	Erdosy	May 2005	B2
6897788	Khair	May 2005	B2
6902905	Burson	Jun 2005	B2
6904301	Raskas	Jun 2005	B2
6905733	Russell	Jun 2005	B2
6908008	Pugh	Jun 2005	B2
6908535	Rankin	Jun 2005	B2
6908591	MacPhee	Jun 2005	B2
6908593	Shartle	Jun 2005	B1
6911130	Brenneman	Jun 2005	B2
6911131	Miyazaki	Jun 2005	B2
6911621	Bhullar	Jun 2005	B2
6911937	Sparrow	Jun 2005	B1
6913210	Baasch	Jul 2005	B2
6913668	Matzinger	Jul 2005	B2
6916410	Katsuki	Jul 2005	B2
6918874	Hatch	Jul 2005	B1
6918901	Theeuwes et al.	Jul 2005	B1
6918918	Schraga	Jul 2005	B1
6922576	Raskas	Jul 2005	B2
6922578	Eppstein	Jul 2005	B2
6923764	Aceti	Aug 2005	B2
6923894	Huang	Aug 2005	B2
6923936	Swanson	Aug 2005	B2
6924093	Haviland	Aug 2005	B2
6925317	Samuels	Aug 2005	B1
6925393	Kalatz	Aug 2005	B1
6929631	Brugger	Aug 2005	B1
6929649	Pugh	Aug 2005	B2
6929650	Fukuzawa	Aug 2005	B2
6931327	Goode	Aug 2005	B2
6931328	Braig	Aug 2005	B2
6939310	Matzinger	Sep 2005	B2
6939312	Hodges	Sep 2005	B2
6939450	Karinka	Sep 2005	B2
6939685	Ouyang	Sep 2005	B2
6940591	Sopp	Sep 2005	B2
6942518	Liamos	Sep 2005	B2
6942769	Cheng	Sep 2005	B2
6942770	Cai	Sep 2005	B2
6944486	Braig	Sep 2005	B2
6945943	Pugh	Sep 2005	B2
6946067	Hodges	Sep 2005	B2
6946098	Miekka	Sep 2005	B2
6946299	Neel	Sep 2005	B2
6949111	Schraga	Sep 2005	B2
6949221	Kiser	Sep 2005	B2
6951631	Catt	Oct 2005	B1
6951728	Qian	Oct 2005	B2
6952603	Gerber	Oct 2005	B2
6952604	DeNuzzio	Oct 2005	B2
6953693	Neel	Oct 2005	B2
6954662	Freger	Oct 2005	B2
6958072	Schraga	Oct 2005	B2
6958129	Galen	Oct 2005	B2
6958809	Sterling	Oct 2005	B2
6959211	Rule	Oct 2005	B2
6959247	Neel	Oct 2005	B2
6960287	Charlton	Nov 2005	B2
6960289	Hodges	Nov 2005	B2
6960323	Guo	Nov 2005	B2
6964871	Bell	Nov 2005	B2
6965791	Hitchcock	Nov 2005	B1
6966880	Boecker	Nov 2005	B2
6966977	Hasegawa	Nov 2005	B2
6967105	Nomura	Nov 2005	B2
6968375	Brown	Nov 2005	B1
6969359	Duchon	Nov 2005	B2
6969450	Taniike	Nov 2005	B2
6969451	Shin	Nov 2005	B2
6973706	Say	Dec 2005	B2
6975893	Say	Dec 2005	B2
6977032	Hasegawa	Dec 2005	B2
6979544	Keen	Dec 2005	B2
6979571	Modzelewski	Dec 2005	B2
6982027	Yagi	Jan 2006	B2
6982431	Modlin et al.	Jan 2006	B2
6983176	Gardner	Jan 2006	B2
6983177	Rule	Jan 2006	B2
6984307	Zweig	Jan 2006	B2
6986777	Kim	Jan 2006	B2
6986869	Tuohy	Jan 2006	B2
6988996	Roe	Jan 2006	B2
6989243	Yani	Jan 2006	B2
6989891	Braig	Jan 2006	B2
6990365	Parker	Jan 2006	B1
6990366	Say	Jan 2006	B2
6990367	Kiser	Jan 2006	B2
6990849	Bohm	Jan 2006	B2
6991918	Keith	Jan 2006	B2
6991940	Carroll	Jan 2006	B2
6994825	Haviland	Feb 2006	B2
6997317	Catelli	Feb 2006	B2
6997343	May	Feb 2006	B2
6997344	Brown	Feb 2006	B2
6997936	Marshall	Feb 2006	B2
6998247	Monfre	Feb 2006	B2
6998248	Yani	Feb 2006	B2
6999810	Berner	Feb 2006	B2
7001343	Erickson	Feb 2006	B2
7001344	Freeman	Feb 2006	B2
7003337	Harjunmaa	Feb 2006	B2
7003340	Say	Feb 2006	B2
7003341	Say	Feb 2006	B2
7004928	Aceti	Feb 2006	B2
7005048	Watanabe	Feb 2006	B1
7005273	Heller	Feb 2006	B2
7005459	Hekal	Feb 2006	B2
7005857	Stiene	Feb 2006	B2
7006857	Braig	Feb 2006	B2
7006858	Silver	Feb 2006	B2
7008384	Tapper	Mar 2006	B2
7010432	Kermani	Mar 2006	B2
7011630	Desai	Mar 2006	B2
7011954	Ouyang	Mar 2006	B2
7014615	Erickson	Mar 2006	B2
7015262	Leong	Mar 2006	B2
7016713	Gardner	Mar 2006	B2
7018568	Tierney	Mar 2006	B2
7018848	Douglas	Mar 2006	B2
7022217	Hodges	Apr 2006	B2
7022218	Taniike	Apr 2006	B2
7022286	Lemke	Apr 2006	B2
7024236	Ford	Apr 2006	B2
7024248	Penner	Apr 2006	B2
7024399	Sumner	Apr 2006	B2
7025425	Kovatchev	Apr 2006	B2
7025774	Freeman	Apr 2006	B2
7027848	Robinson	Apr 2006	B2
7029444	Shin	Apr 2006	B2
7033322	Silver	Apr 2006	B2
7033371	Alden	Apr 2006	B2
7039560	Kawatahara	May 2006	B2
7041057	Faupel	May 2006	B1
7041063	Abreu	May 2006	B2
7041068	Freeman	May 2006	B2
7041210	Hodges	May 2006	B2
7041254	Haviland	May 2006	B2
7041468	Drucker	May 2006	B2
7043287	Khalil	May 2006	B1
7043821	Hodges	May 2006	B2
7044911	Drinan	May 2006	B2
7045046	Chambers	May 2006	B2
7045054	Buck	May 2006	B1
7045097	Kovacs	May 2006	B2
7045310	Buck	May 2006	B2
7045361	Heiss	May 2006	B2
7047070	Wilkinson	May 2006	B2
7047795	Sato	May 2006	B2
7049087	Jenny	May 2006	B2
7049130	Carroll	May 2006	B2
7050843	Shartle	May 2006	B2
7051495	Lang	May 2006	B2
7052268	Powell	May 2006	B2
7052591	Gao	May 2006	B2
7052652	Zanzucchi	May 2006	B2
7052864	Durkop	May 2006	B2
7054682	Young	May 2006	B2
7054759	Fukunaga	May 2006	B2
D522656	Orr	Jun 2006	S
D523555	Loerwald	Jun 2006	S
7056425	Hasegawa	Jun 2006	B2
7056495	Roser	Jun 2006	B2
7058437	Buse	Jun 2006	B2
7059352	Bohm	Jun 2006	B2
7060059	Keith	Jun 2006	B2
7060168	Taniike	Jun 2006	B2
7060192	Yuzhakov	Jun 2006	B2
7061593	Braig	Jun 2006	B2
7063234	Giraud	Jun 2006	B2
7063774	Bhullar	Jun 2006	B2
7063775	Yamaoka	Jun 2006	B2
7063776	Huang	Jun 2006	B2
7066884	Custer	Jun 2006	B2
7066885	Erickson	Jun 2006	B2
7070564	Matzinger	Jul 2006	B2
7070680	Bae	Jul 2006	B2
7073246	Bhullar	Jul 2006	B2
7074307	Simpson	Jul 2006	B2
7074308	Mao	Jul 2006	B2
7077328	Krishnaswamy	Jul 2006	B2
7077828	Kuhr	Jul 2006	B2
7078480	Nagel	Jul 2006	B2
7079252	Debreezeny	Jul 2006	B1
7081188	Cho	Jul 2006	B1
7083712	Morita	Aug 2006	B2
7086277	Tess	Aug 2006	B2
7087149	Muguruma	Aug 2006	B1
7090764	Iyengar	Aug 2006	B2
7096053	Loeb	Aug 2006	B2
7096124	Sterling	Aug 2006	B2
7097631	Trautman	Aug 2006	B2
7098038	Fukuoka	Aug 2006	B2
7103578	Beck	Sep 2006	B2
7107253	Sumner	Sep 2006	B1
7108680	Rohr	Sep 2006	B2
7108778	Simpson	Sep 2006	B2
7109271	Liu	Sep 2006	B2
7110112	Uchida	Sep 2006	B2
7110803	Shults	Sep 2006	B2
7112265	McAleer	Sep 2006	B1
7112451	Takahashi	Sep 2006	B2
7113172	Hohl	Sep 2006	B2
7115362	Douglas	Oct 2006	B2
7118351	Effenhauser	Oct 2006	B2
7118667	Lee	Oct 2006	B2
7118668	Edelbrock	Oct 2006	B1
7118916	Matzinger	Oct 2006	B2
7118919	Yatscoff	Oct 2006	B2
7120483	Russell	Oct 2006	B2
7122102	Wogoman	Oct 2006	B2
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7122111	Tokunaga	Oct 2006	B2
7125481	Musho	Oct 2006	B2
7129038	Gopalan	Oct 2006	B2
RE39390	Hasegawa	Nov 2006	E
D531725	Loerwald	Nov 2006	S
7131342	Hodges	Nov 2006	B2
7131984	Sato	Nov 2006	B2
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7134550	Groth	Nov 2006	B2
7134999	Brauker	Nov 2006	B2
7135100	Lau	Nov 2006	B1
7137957	Erickson	Nov 2006	B2
7138041	Su	Nov 2006	B2
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7141058	Briggs	Nov 2006	B2
7144404	Whitson	Dec 2006	B2
7144485	Hsu	Dec 2006	B2
7144495	Teodorczyk	Dec 2006	B2
7144496	Meserol	Dec 2006	B2
7144709	Ouyang	Dec 2006	B2
7147825	Matsuda	Dec 2006	B2
7150755	Levaughn	Dec 2006	B2
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7150995	Xie	Dec 2006	B2
7153696	Fukuoka	Dec 2006	B2
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7156117	Bohm	Jan 2007	B2
7156810	Cho	Jan 2007	B2
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7167734	Khalil	Jan 2007	B2
7167735	Uchida	Jan 2007	B2
7167818	Brown	Jan 2007	B2
7169116	Day	Jan 2007	B2
7169117	Allen	Jan 2007	B2
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7169600	Hoss	Jan 2007	B2
7172728	Otake	Feb 2007	B2
7174199	Berner	Feb 2007	B2
7175641	Schraga	Feb 2007	B1
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7192450	Brauker	Mar 2007	B2
7195704	Kermani	Mar 2007	B2
7198606	Boecker	Apr 2007	B2
7199594	Kermani	Apr 2007	B2
7202854	Hohl	Apr 2007	B2
7206620	Erickson	Apr 2007	B2
7206623	Blank	Apr 2007	B2
D542681	Young	May 2007	S
7211052	Roe	May 2007	B2
7211096	Kuhr	May 2007	B2
7212925	Genshaw	May 2007	B2
7213720	Giraud	May 2007	B2
7215982	Oshima	May 2007	B2
7215983	Cho	May 2007	B2
7223248	Erickson	May 2007	B2
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7225535	Feldman et al.	Jun 2007	B2
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7228159	Petersson	Jun 2007	B2
7228162	Ward	Jun 2007	B2
7228163	Ackerman	Jun 2007	B2
7229458	Freeman et al.	Jun 2007	B2
7232451	Boecker	Jun 2007	B2
7232510	Miyazaki	Jun 2007	B2
7233816	Blank	Jun 2007	B2
7235056	Duchon	Jun 2007	B2
7235170	Watanabe	Jun 2007	B2
7235378	Yonehara	Jun 2007	B2
7236812	Ballerstadt	Jun 2007	B1
7236814	Shioi	Jun 2007	B2
D545705	Voege	Jul 2007	S
D546216	Bolognesi	Jul 2007	S
D546218	Grasso	Jul 2007	S
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Related Publications (1)

	Number	Date	Country
	20070142747 A1	Jun 2007	US

Divisions (1)

	Number	Date	Country
Parent	10335258	Dec 2002	US
Child	11548533		US

Continuation in Parts (1)

	Number	Date	Country
Parent	10127395	Apr 2002	US
Child	10335258		US

Method and apparatus for penetrating tissue

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Abstract