The present application relates to systems and methods for combined radiotherapy and magnetic resonance imaging, particularly systems and methods that involve shielding magnetic fields and radiofrequency radiation from the radiotherapy and magnetic resonance imaging systems.
A linear particle accelerator (also called a linac) is a type of particle accelerator used to accelerate subatomic ions at great speeds. Linacs are described, for example, by C. J. KARZMARK ET AL., MEDICAL ELECTRON ACCELERATORS (McGraw-Hill, Inc., Health Professions Division 1993), which is hereby incorporated by reference. Medical grade or clinical linacs (a.k.a. clinacs) accelerate electrons using a tuned-cavity waveguide in which the Radio frequency (RF) power typically creates a standing or traveling wave for the generation of high energy electrons or Bremsstrahlung X-rays for medicinal purposes.
Magnetic Resonance Imaging (MRI), or nuclear magnetic resonance imaging (NMRI), is primarily a medical imaging technique most commonly used in radiology to visualize the internal structure and function of the body. MRI is described, for example, by E. MARK HAACKE ET AL., MAGNETIC RESONANCE IMAGING: PHYSICAL PRINCIPLES AND SEQUENCE DESIGN (Wiley-Liss 1999), which is hereby incorporated herein by reference.
It is desirable to be able to image with an MRI unit while being able to simultaneously perform radiation therapy using a linac. However, there are two major conflicts between the linac and MM unit that should be overcome for these technologies to work together in a clinically acceptable way. The first problem is that the MM unit's magnetic field accelerates charged particles in the linac by the Lorentz force on charged particles in a magnetic field determined by the equation F=q (v×B), where F is the force on the charged particle, q is the charge of the particle, v is the velocity, and B is the magnetic field. In linear accelerators, the electrons “ions” are typically generated by heating a thermionic material (a material where the electrons become detached when heated), which is the cathode, and when a positive voltage is applied to an anode (which is typically a wire grid), the electrons move from the cathode towards the anode. The anode is pulsed at 100's of megahertz such that the grouping of electrons pass thru the grid and on to be further accelerated. The cathode, anode, and later accelerating components form what is called the electron gun, and this gun can be shut down by an external magnetic field such that it will not produce electrons for further acceleration. The MRI magnet is usually shielded to reduce the magnetic field surrounding the magnet. Usually this magnetic fringe field remains above the level of the earth's 1 gauss magnetic field for a few meters from the MRI isocenter. The optimal distance for locating a linac near the patient is with the source at approximately one meter from the radiotherapy isocenter. For a system where the MRI and radiotherapy isocenters are substantially coincident, this puts the linac in a fringe field that could easily be on the order of 0.1 tesla (T, 1T=10,000 gauss) or higher. The magnetic field B vector is significant and oriented axial to the MR system (Z). The velocity v vector approaches the speed of light and is nominally at right angles (Y) to the B vector. The force F on the very light electron will accelerate the electrons perpendicularly out of their desired trajectory.
The second problem is that the high-powered RF source of the linac causes interference with the radiofrequency transmitter and receiver for signal detection in the MRI unit. The RF frequency transmit and (especially) receive coils employed are extremely sensitive and usually limited by thermal noise in the patient and RF coil structure. Gradient magnetic fields are used to set a range of frequencies around this central frequency to provide position information as a function of frequency. The high-powered RF source in the linac typically generates megawatt to tens of megawatt bursts of RF radiation tuned to the resonating cavity of the accelerator at several hundred Hertz during operation. This high-powered RF radiation is typically not on resonance with the MRI frequencies of operation, but has side bands at the MRI frequencies and can induce eddy currents in the conducting components of the MM causing signal corruption or even damaging the MRI electronics. MM systems usually include an RF shielded room to limit interference from external RF sources. The sensitive MRI receive-RF coils also need to be protected from the RF transmit field used for excitation. Usually this isolation is done with PIN diodes and/or back-to-back diodes, switching in/out tuned/detuned circuit elements that attenuate the RF induced signal. Further, it is important that the sensitive MRI pre-amps do not go into saturation with RF energy from any source.
U.S. Pat. No. 6,198,957 to Green, titled “Radiotherapy Machine Including Magnetic Resonance Imaging System” (hereinafter “Green”), teaches the combination of a MRI system and a horizontal linac. Green teaches that DC coils should extend around the horizontal linac to shield the MRI from magnetic fields produced by the linac and that DC coils should be used around the MM to shield the linac from the leakage magnetic field of the MRI. Also, Green teaches that, for a linac that uses an electron beam, the main magnets of the MRI must be pulsed off while the electron beam of the linac is pulsed on. In an analogous way, PCT International Publication WO2004/024235 to Lagendijk et al., titled “MM in Guided Radiotherapy Apparatus with Beam Heterogeneity Compensators” (hereinafter “Lagendijk”), teaches integrating DC coils into the design of the main magnet of the MRI to create a toroidal low field region outside the MRI to shield the linac electron gun source from the MM leakage magnetic field. Lagendijk also teaches the design of a main magnet that provides limited shielding on the electron gun of the linac and allows higher fields along the accelerating path toward the linac target, though this permits further degradation of the beam and that requires correction with additional filters. Again, in a similar way, PCT International Publication WO2007/045076 to Fallone et al., titled “Integrated External Beam Radiotherapy and MRI System” (hereinafter “Fallone”), teaches that a shielding interface between the MRI and linac can be used if the linac and MM are fixed to each other to allow shimming, as was disclosed by Green. Also, Fallone teaches the use of steering coils associated with the linac for detecting and correcting for deviations of the linac electron beam due to the magnetic field of the MRI. Finally, U.S. Patent Application Publication 2008/0208036 to Amies et al., titled “Combined Radiation Therapy and Magnetic Resonance Unit” (hereinafter “Amies”), teaches that the linac can be placed completely inside the MM main magnet bore with the path of the accelerated electrons aligned with the main magnetic field lines, however, this shortens the distance of the linac from isocenter. This also limits the beam path to be exactly along the central axis of the magnet. In a horizontal bore magnet, the magnetic field lines begin to diverge away from the central axis as you approach either end of the magnet, and in so doing turn in a radial direction. Thus, the beam must be exactly along the central axis or else it will be effected by the radial components of the field toward the ends. The MM also uses “pulsed gradient fields” which can also have significant radial components off the central axis. Each of these references also teach the shielding of the linac from the MRI magnetic field where shielding material is interposed or interfacing between the beam source and the patient.
Prototypes of the devices taught by Lagendijk (and related its applications) and Fallone have demonstrated that the shielding leads to very large devices that cannot fit in the standard linac (or clinac) room and present many technical challenges where significant compromises must be made in the quality of the radiotherapy that can be delivered, either requiring the radiotherapy devices to treat from large distances or through a large amount of material that can scatter and attenuate the beam, compromising the quality of the radiotherapy. Additionally, these prototypes have employed RF shielding boxes that completely enclose the MM from the linac and the treatment room, making patient access an issue.
As will be appreciated, there exists a need for an improved solution to the shielding of an MRI and linac from each other that, among other things, mitigates the disadvantages of having to pass the radiotherapy beams through a large amount of material or from long distances.
Disclosed herein are methods and apparatus embodiments that allow for the production of a combined linac and MRI device. A method of shielding the RF radiation of the linac without sealing off the MRI is also described. Embodiments disclosed herein describe shielding to isolate the linac from the magnetic field of the MRI magnet and the RF transmit/receive coils from the linac RF field. A novel method of shielding the linac from the leakage magnetic field of the MRI at the standard position, i.e., about one meter from the radiotherapy isocenter, without placing shielding material between the patient and the incident beam, thereby preventing the degradation of the beam, is taught with shimming and correction of the homogeneous MM magnetic field with gantry and MRI bore mounted shims; the gantry mounted shims being able to rotate with the linac. Magnetic shielding can be done with ferromagnetic shields and local coils, or combinations thereof, that are placed around the linac, yet not in the path of the beam. RF shielding of the MM system is achieved by the selective use of a combination of uniform RF radiation absorbing materials, such as carbon fiber mesh, and RF radiation reflective materials, such as copper shielding. The beam is allowed to pass through the RF shielding as it can be constructed to be part of the flattening filter attenuation or can be made with a thin section or hole to pass the beam. The absorbing and attenuating materials can be layered successively to reflect, attenuate, and/or absorb the RF radiation from the linac. Cooling can be provided to the absorbing material as necessary to remove heat generated by the RF radiation being absorbed.
According to some aspects of the present disclosure, a magnetic shield can be provided about a linac. The shield can include one or more shells of high magnetic susceptibility and permeability layers, current carrying coils, permanent magnets, or any combination thereof, to shield the linac from the magnetic field of a MRI system in order to allow for proper operation of the linac. The shells are preferrably cylindrical, but other shapes can be used.
In embodiments that include more than one of the shells, the shells are preferrably magnetically isolated from each other.
The shield can be arranged so that the magnetic field of the MRI system does not attenuate the radiotherapy beam. The shield can operate at a preferred distance for linac placement. The inner layers of the shield can have higher permeability but saturate at a lower flux density. The influence of the shield on the homogeneous region of the MM magnetic field can be diminished and balanced by an opposed dummy shield.
The influence of the shield on the MRI magnetic field can be corrected by shims. For example, gantry mounted shims can correct perturbations that follow the gantry angle of linac. MRI bore mounted shims and/or magnet design can correct for perturbations that are independent of the gantry angle of the linac.
According to further aspects of the present disclosure, an RF shield about a linac can include one or more layers of RF absorbing materials, and/or RF reflecting materials, or combinations of both, to contain the RF radiation and/or shield the MM from the high power RF radiation produced by the linac in order to allow for proper operation of the MM.
The RF shield can be arranged so that the beam passes through the shield with uniform attenuation. The RF shield can also be arranged so that the flattening filter is part of the RF shield. A thin section or hole can be used to limit beam attenuation.
Shielding can be improved by the application of RF absorbing materials to one or more of the RF room interior walls, the MM surfaces, and the former for winding the gradient coils.
Features, aspects, and embodiments of the inventions are described in conjunction with the attached drawings, in which:
The radiation therapy system 100 includes an open split solenoidal magnetic resonance imaging (MM) device 102, a radiation source 104, a gantry 106 for housing a linac 107 and for changing the angle of radiation source 104, a patient couch 108, and a patient 110 in position for imaging and treatment. A similar system is described in U.S. Patent Application Publication 2005/0197564 to Dempsey, titled “System for Delivering Conformal Radiation Therapy while Simultaneously Imaging Soft Tissue” (hereinafter “Dempsey '564”), which is hereby incorporated by reference.
The radiation therapy system 100 of the present disclosure differs in many respects from that disclosed in Dempsey '564, a primary difference being that the radiation therapy system 100 of the present disclosure includes a linac 107 rather than the isotopic radiation system disclosed in Dempsey '564. Except as described herein, the linac 107 can be of conventional design. In some embodiments, the linac 107, best shown in
The radiation therapy system 100 can include a split magnet system, such as described in Dempsey '564. The split magnet system includes a pair of main magnets 112a and 112b as shown in
In the system 100 of the present embodiment, at a distance of 1 m from magnet isocenter IC on the central plane CP, there is a magnetic field of Bz z 0.1T, shown as point P1, which is a desired distance from isocenter for the source of the radiation of the linac 107. The magnetic field reverses direction from +Bz to −Bz at a radial distance of 0.81 m, shown as point P2. The magnet field at 1 m from isocenter, where the linac 107 radiation source is preferrably located for optimal radiotherapy operation, is low enough that it can be contained in a ferromagnetic shield or multiple layered shields, as described below. In the central axial plane CP, there is mainly axial magnetic field Bz because of coil symmetry. In the central plane CP, we assume that Y is a vertical axis and the axis of a high magnetic susceptibility (and/or permeability in a linear domain) material, e.g., a non-oriented silicon-steel shell, for shielding the linac 107.
The field generated by the main magnets 112a and 112b near the central plane CP is shown in
The linac 107 has a longitudinal axis p that is aligned with the Y-axis in
Turning next to
The magnets 112a and 112b, and the location of the magnetic shield 118, are illustrated in
The model of the influence of the material, which in this embodiment is steel, in the presence of the main magnets 112a and 112b was solved using Maxwell's equations via the boundary element method.
The residual magnetic field along the axis of a single 5 mm thick shell is about 4.5 G, approximately ten times greater that the earth's magnetic field and larger than optimal for the linac 107. There are several options to further reduce this residual field. As shown in
Alternatively, the secondary shielding element 120 can be a current carrying coil that is located inside of the primary shell 118 to cancel the residual field. If the magnetic field remaining is sufficiently low and its value and direction in space are known, then it can be possible to make small adjustments in the accelerating portion of the linac The current linacs are configured to accommodate an electron beam that is at least substantially straight; if the beam were bent only a small amount by the field, the anticipated beam path can be calculated and the accelerating plates can be altered to accommodate the beam bending. Given the azimuthally symmetric nature of the fringe field, the path deviation of the electron beam should be largely independent of gantry position. As another alternative, the secondary shielding element 120 can be an RF shield 120, as further described below.
The peak-to-peak field in-homogeneity of the system main magnets 112a and 112b plus the double shell is 623.8 ppm over 45 cm DSV. This inhomogeneity is too large for MRI system 102, so additional shimming is desirable. The field inhomogeneity is mostly represented by a few of the tesseral harmonics; S1,1→Y, C2,2→(X2-Y2), and S3,1→Z2X, and S3,3→X3. All of the major harmonics of significance are listed in Table 2.
The zonal harmonics can all be handled by shimming, and the shim setting does not change with rotation of the linac 107 around the Z-axis. Hence, the shims can be located on the MRI bore. The negative of the zonal harmonics could even be built into the magnets 112a and 112b so that the combination of magnets 112a, 112b plus magnetic shield 118 eliminates these terms. The tesseral harmonics are a larger problem because they would move with the linac orientation. The tesseral harmonics could be shimmed out with passive shims near the central plane CP on the gantry 106 that would move with the gantry 106/linac 107 rotation and/or with resistive shims built into the gradient coil that could be electrically adjusted to match the rotation of the gantry 106.
According to some embodiments, the system 100 as shown in
In some embodiments, particularly where the RF shield shell is formed of conductive material, the eddy currents can be reduced by providing one or more slots that extend through the shield shell. For example, shield shell 120 is shown as having slots 120A and 120B in
While
Cooling can be provided by cooling system 115 (
The magnetic shield 118 and the RF shield 120 are placed around the linac 107 to shield the path of the electrons from the electron gun 107b of the linac 107 to the target to a magnetic field strength on the order of the size of the earth's magnetic field strength. The magnetic shield 118 is arranged such that it is not in the path of the radiotherapy beam, for example as shown in
As mentioned above, in some embodiments, the secondary shielding element 120 shown in
The residual B-field is less than 1 Gauss in the region 1100 mm<y<1400 mm. This is roughly comparable to the earth's field close to the axis p. The harmonics of the magnetic field are close to the single shell model associated with the embodiment shown in
The methods to be used to shim out this inhomogeneity are the same as those proposed in the case of the single shell model.
Referring next to
The zonal harmonics are now twice as large as in the single shell model associated with the embodiment shown in
In still further embodiments, there can be N sets of magnetic shield shells identical or similar to magnetic shield 118, each having a respective axis pi through ρN. Such embodiments can be arranged in a manner similar to the embodiment shown in
In some embodiments, as shown in
The magnetic field from the main magnets 112a and 112b at 1 meter from isocenter along the Y-axis is difficult to shield without the field reduction of passive shields, such as shield 118 described above. However, after the magnetic shielding provided by the ferromagnetic material, the residual field is near 5-7 Gauss. This residual field can easily be shimmed out with DC current in a coil, for example in embodiments where the secondary shielding element 120 shown in
The current density on the cylinder of radius R can be presented in the following form:
(ρ,φ,z)=δ(ρ−R){êφ(z)cos(φ)+êZfZ(z)sin(φ)}∇
The magnetic potentials generated by this current can be expressed as follows:
In this equation, In (kρ),Kn (kρ) are modified Bessel functions. The transverse components of the magnetic field can be presented in the following form:
The Bx-component of the magnetic flux field inside the cylinder of the coil 120′ is:
This Bx-component (in the local system of coordinates) should cancel the Bz′-component produced by the magnet. This suggests that a minimization procedure can be applied (similar to that of the gradient design) to find the currents density fz(z). We consider a functional to be minimized:
In the above equation, E is the energy of the coil 120′, the second term is to minimize the deviation of the field produced by the shielding coil 120′ from that of the main magnets 112a, 112b, the third term is to minimize the effect of the shield coil 120′ on the field in-homogeneity in the imaging volume, and the last term is introduced as to limit the current density. The coefficients Λ, β, and λ are the weighting factors; λ can be a regularization parameter to minimize the current in the shielding coil 120′.
The current density fz(z) can be expressed in terms of a basis functions. It should be mentioned that the current density fz(z) is zero at the ends of the shielding coil 120′.
The coefficients an can be found from the following equation:
This is leading to a system of linear equation for the coefficients αn. The energy E has the following form:
The field produced by the shield coil 120′ has the following form:
Then the equation for the unknown A holds:
The matrix Zαβ is positive defined and does not have zero eigenvalue, thus:
This defines the solution for the current density.
Some embodiments can include a combined passive shield and active coil. The residual Bz-field shown in
The following parameters Λ, β, K, and λ were used: Λ=1, β=0, K=1, and λ=0.0001. The parameter β that accounts for the effect of correcting the in-homogeneity inside the DSV was chosen to be zero because the level of the residual field of
Some embodiments can include a completely active coil shielding system. In such embodiments, the shielding of the linac 107 can be accomplished locally using only the above-described active current-carrying coils, such as coil 120′, in place of the passive magnetic shields in embodiments described above. The coils 120′ can be arranged to simply cancel the field at the linac 107 and can also incorporate an active shield to reduce the influence on the homogeneity of the main magnetic field.
Still another alternative way of shielding the linac 107 locally is to use a distribution of permanent magnets. They can be arranged to simply cancel the field at the linac 107 and can also incorporate an active shield, such as coil 120′, to reduce the influence on the homogeneity of the main magnetic field from the main magnets 112a and 112b.
All possible combinations of the disclosed embodiments are also possible. Small variations to the shields and distributions of the shielding materials, current carrying coils, and magnet distributions are also possible.
It should be noted that the magnetic shields described herein, such as shields 118, 120, 122, 130, 132, and others experience a force from the main magnets 112a and 112b of the MM 102. Thus, the mounting for the shields is preferably designed to withstand such magnetic forces.
The high-power RF source and waveguide for the linac 107 can also be enclosed, or partially enclosed, within the magnetic shields disclosed herein. The RF shielding can be extended to contain some or all components of the linac 107.
Regarding RF screening for the MM 102, clinical linacs suitable for use as linac 107 can operate in the S-band frequency range accelerate electrons to about 6 MeV using RF microwave cavities at ˜3 GHz. While this frequency is well above the 15 MHz of the MRI system 102, it involves megawatts of RF power pulse with a frequency of several hundred Hertz. Sidebands in the RF power source can excite/reflect from other materials causing interference with the operation of the MM system 102. As mentioned above in connection with
While various embodiments in accordance with the disclosed principles have been described above, it should be understood that they have been presented by way of example only, and are not limiting. Thus, the breadth and scope of the invention(s) should not be limited by any of the above-described exemplary embodiments, but should be defined only in accordance with the claims and their equivalents issuing from this disclosure. Furthermore, the above advantages and features are provided in described embodiments, but shall not limit the application of such issued claims to processes and structures accomplishing any or all of the above advantages.
Additionally, the section headings herein are provided for consistency with the suggestions under 37 C.F.R. 1.77 or otherwise to provide organizational cues. These headings shall not limit or characterize the invention(s) set out in any claims that may issue from this disclosure. Specifically and by way of example, although the headings refer to a “Technical Field,” such claims should not be limited by the language chosen under this heading to describe the so-called technical field. Further, a description of a technology in the “Background” is not to be construed as an admission that technology is prior art to any invention(s) in this disclosure. Neither is the “Summary” to be considered as a characterization of the invention(s) set forth in issued claims. Furthermore, any reference in this disclosure to “invention” in the singular should not be used to argue that there is only a single point of novelty in this disclosure. Multiple inventions may be set forth according to the limitations of the multiple claims issuing from this disclosure, and such claims accordingly define the invention(s), and their equivalents, that are protected thereby. In all instances, the scope of such claims shall be considered on their own merits in light of this disclosure, but should not be constrained by the headings set forth herein.
This application is a continuation and claims benefit of priority under 35 U.S.C. § 120 of U.S. patent application Ser. No. 17/174,116, filed Feb. 11, 2021, entitled “Method And Apparatus For Shielding A Linear Accelerator And A Magnetic Resonance Imaging Device From Each Other,” which claims the benefit of priority under 35 U.S.C. § 120 of U.S. patent application Ser. No. 16/362,094, filed Mar. 22, 2019 and issued as U.S. Pat. No. 10,918,887, entitled “Method And Apparatus For Shielding A Linear Accelerator And A Magnetic Resonance Imaging Device From Each Other,” which claims the benefit of priority under 35 U.S.C. § 120 of U.S. patent application Ser. No. 15/242,449, filed Aug. 19, 2016 and issued as U.S. Pat. No. 10,463,883, entitled “Method And Apparatus For Shielding A Linear Accelerator And A Magnetic Resonance Imaging Device From Each Other,” which claims the benefit of priority under 35 U.S.C. § 120 of U.S. patent application Ser. No. 14/481,619, filed Sep. 9, 2014 and issued as U.S. Pat. No. 9,421,398, entitled “Method And Apparatus For Shielding A Linear Accelerator And A Magnetic Resonance Imaging Device From Each Other”, which claims the benefit of priority under 35 U.S.C. § 120 of U.S. patent application Ser. No. 12/837,309, filed Jul. 15, 2010 and issued as U.S. Pat. No. 8,836,332, entitled “Method And Apparatus For Shielding A Linear Accelerator And A Magnetic Resonance Imaging Device From Each Other”, which claims the benefit of priority under 35 U.S.C. § 119 of U.S. Provisional Application No. 61/225,771, filed Jul. 15, 2009, entitled “Method And Apparatus For Shielding A Linear Accelerator And A Magnetic Resonance Imaging Device From Each Other.” These references are incorporated herein by reference in their entirety for all purposes.
Number | Date | Country | |
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61225771 | Jul 2009 | US |
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Parent | 17174116 | Feb 2021 | US |
Child | 17948428 | US | |
Parent | 16362094 | Mar 2019 | US |
Child | 17174116 | US | |
Parent | 15242449 | Aug 2016 | US |
Child | 16362094 | US | |
Parent | 14481619 | Sep 2014 | US |
Child | 15242449 | US | |
Parent | 12837309 | Jul 2010 | US |
Child | 14481619 | US |