Method and composition for eliminating odors in ion exchange resins

Abstract

A method for reducing undesirable odor of an anion exchange resins by preparing a composition comprising an admixture comprising an anion exchange resin having an undesirable odor and a cation exchange resin; and converting the mixture to form the composition.

Description

EXAMPLES

Example 1

Evaluation of the Effect of Amberlite® IRP64 on the Odor of Duolite® AP143

Amberlite® IRP64 is a resin derived form a porous copolymer of methacrylic acid and divinylbenzene and available from Rohm and Haas Company, Philadelphia, Pa. Duolite® AP143 (cholestyramine available from Rohm and Haas Company, Philadelphia, Pa.) is a strongly basic anion exchange resin in the chloride form. It is a dry, finely ground solid used in pharmaceutical formulations. Several samples of mixtures of AP143 and IRP64 were prepared and evaluated for amine odor within an hour of preparation. The evaluation was done by three different observers (Obs 1, Obs 2, and Obs 3) and ranked on a scale of 0-5 as follows:

0 None
1 Faint/trace
2 Definite odor, but weak
3 Moderate odor
4 Stronger odor
5 Strong (defined as untreated cholestyramine)

The results are given in Table 1.

TABLE 1
% w/w IRP64	Obs 1	Obs 2	Obs 3	Mean
0	5	5	5	5
0.3	2	2	3	2.3
1	0	0	3	1
5	0	0	1	0.3
20	0	0	2	0.7

The results indicate a reduction in amine odor with the addition of IRP64. Increasing the amount of IRP64 reduces the odor.

The samples we re-evaluated by Observer 1 after ˜1 month. The odor scores were the same as the 1 hour scores reported in Table 1.

Example 2

Evaluation of the Effect of Amberlite® IRP64 on the Odor of Amberlite® IRA900 OH

IRA900 OH is a whole bead strongly basic anion exchange resin in the hydroxide form supplied as a wet solid. It is used in water treatment and is characterized by a strong amine odor due to the high pH of the material. The odor associated with this product is typically rated as stronger than that of AP143.

35 ml of wet resin was mixed with 1 g of IRP64, (approximately 4.4% w/w), and the odor was evaluated within 5 minutes by three observers (Observer 1, Observer 4, and Observer 5). In all three cases, the odor was scored as 0.

Claims

1. A composition comprising: an anion exchange resin having an undesirable odor; anda cation exchange resin, a ratio of cation exchange resin to anion exchange resin being 0.1:99.9 to 25:75.

2. The composition of claim 1 wherein the undesirable odor is caused by at least one of an ammonia and an organic amine.

3. The composition of claim 1 wherein the anion exchange resin comprises at least one of a weakly basic anion exchange resin and a strongly basic anion exchange resin.

4. The composition of claim 1 wherein the anion exchange resin comprises cholestyramine.

5. The composition of claim 1 wherein the cation exchange resin comprises a weakly acidic exchange resin having carboxylic functionality.

6. The composition of claim 1 wherein the ratio comprises 0.2:99.8 to 5:95.

7. The composition of claim 1 wherein the anion exchange resin comprises an active ingredient.

8. The composition of claim 1 wherein the composition comprises at least one of a pharmaceutical, a neutraceutical, and a cosmeceutical composition.

9. A process for preparing a composition comprising providing an admixture comprising an anion exchange resin having an undesirable odor and a cation exchange resin, a ratio of cation exchange resin to anion exchange resin being 0.1:99.9 to 25:75; andconverting the mixture to form the composition.

10. The process of claim 9 wherein the anion exchange resin comprises at least one of a weakly basic anion exchange resin and a strongly basic anion exchange resin and the acidic cation exchange resin comprises a weakly acidic exchange resin having carboxylic functionality.