Claims
- 1. A pharmaceutical preparation comprising a combination of a Dipeptidyl Peptidase IV inhibitor and a Neutral Endopeptidase (NEP) inhibitor, or a pharmaceutically acceptable salt of either or both inhibitors.
- 2. A pharmaceutical preparation according to claim 1, wherein the Dipeptidyl Peptidase IV inhibitor is a N-substituted adamantyl-amino-acetyl-2-cyano pyrrolidine or a N-(substituted glycyl)-4-cyano pyrrolidine.
- 3. A pharmaceutical preparation according to claim 1, wherein the Dipeptidyl Peptidase IV inhibitor is a compound of formula I
- 4. A pharmaceutical preparation according to claim 1, wherein the Dipeptidyl Peptidase IV inhibitor is a compound of formula II
- 5. A pharmaceutical preparation according to claim 1, wherein the Dipeptidyl Peptidase IV inhibitor is a compound of formula III
- 6. A pharmaceutical preparation according to claim 1, wherein the NEP inhibitor is candoxatril.
- 7. A pharmaceutical preparation according to claim 1, wherein the NEP inhibitor is a dual NEP/Angiotensin Converting Enzyme (ACE) inhibitor
- 8. A pharmaceutical preparation according to claim 1, wherein said preparation further comprises an antidiabetic agent.
- 9. A pharmaceutical preparation according to claims 1, wherein said preparation further comprises an Angiotensin Converting Enzyme (ACE) inhibitor.
- 10. A method of treating a condition that may be regulated or normalised via inhibition of Dipeptidyl Peptidase-IV and Neutral Endopeptidase enzyme activities, said method comprising administering to an individual in need thereof an effective amount of a Dipeptidyl Peptidase-IV inhibitor and an effective amount of a Neutral Endopeptidase inhibitor.
- 11. A method according to claim 10, wherein the condition is type 2 diabetes.
- 12. A method according to claim 10, wherein the condition is a condition requiring use of diuretic agents.
- 13. A method according to claim 12, wherein the condition is selected from the group consisting of hypertension, fluid retention, swelling of the ankles, peripheral oedema, fatigue, dyspnoea, pulmonary oedema, emphysema, peripheral vascular disease, atherosclerosis, intermittent claudication, angina pectoris, re-occlusion of coronary arterial grafts, cerebrovascular stroke, ischaemic heart disease, myocardial infarction, valvular heart disease, congenital heart disease, cardiomyopathy, and fluid retentive states.
- 14. A method according to claim 10, wherein the Dipeptidyl Peptidase-IV inhibitor is a compound according to claim 3.
- 15. A method according to claim 10, wherein the Dipeptidyl Peptidase-IV inhibitor is a compound according to claim 4.
- 16. A method according to claim 10, wherein the Dipeptidyl Peptidase-IV inhibitor is a compound according to claim 5.
- 17. A method according to claim 10, wherein the Neutral Endopeptidase inhibitor is candoxatril.
- 18. A method according to claim 10, wherein the Dipeptidyl Peptidase-IV inhibitor and the Neutral Endopeptidase inhibitor are administered simultaneously.
- 199. A method according to claim 10, wherein the Dipeptidyl Peptidase-IV inhibitor and the Neutral Endopeptidase inhibitor are administered separately.
- 20. A method according to claim 10, wherein the Dipeptidyl Peptidase-IV inhibitor and the Neutral Endopeptidase inhibitor are administered sequentially.
- 21. A method according to claim 10, wherein the Dipeptidyl Peptidase-IV inhibitor and the Neutral Endopeptidase inhibitor are a single compound which is a dual Dipeptidyl Peptidase-IV/Neutral Endopeptidase inhibitor.
- 22. A method according to claim 10, wherein the Dipeptidyl Peptidase-IV inhibitor and the Neutral Endopeptidase inhibitor are in separate pharmaceutical preparations.
- 23. A method according to claim 10, wherein the Dipeptidyl Peptidase-IV inhibitor and the Neutral Endopeptidase inhibitor are in a single pharmaceutical preparation.
Priority Claims (1)
Number |
Date |
Country |
Kind |
PA 2002 00047 |
Jan 2002 |
DK |
|
CROSS REFERENCE TO RELATED APPLICATIONS
[0001] This application is a continuation of application serial no. PCT/DK03/00017 filed on Jan. 13, 2003 and claims priority under 35 U.S.C. 119 of Danish application no. PA 2002 00047 filed Jan. 11, 2002 and U.S. provisional application No. 60/348,332 filed Jan. 14, 2002, the contents of which are fully incorporated herein by reference.
Provisional Applications (1)
|
Number |
Date |
Country |
|
60348332 |
Jan 2002 |
US |
Continuations (1)
|
Number |
Date |
Country |
Parent |
PCT/DK03/00017 |
Jan 2003 |
US |
Child |
10421465 |
Apr 2003 |
US |