This application includes subject matter, and claims the priority date of Israel Patent Application No. 168424, filed on May 5, 2005, the content of which is incorporated herein by reference.
The present invention relates to a method and apparatus for controlling medical imaging systems, such as magnetic resonance imaging (MRI) systems, and computer tomography (CT) systems, as well as X-ray, ultrasound, and other types of medical imaging systems. The invention particularly relates to controlling the gating of such imaging systems in order to reduce motion-generated artifacts therein resulting from movement of the patient during imaging, and thereby to produce sharper and clearer images.
The quality of the images produced in a medical imaging system depends to a large extent on the technique used for gating or synchronizing the operation of the imaging system. The common gating technique in present use is based on the ECG (electrocardiogram) signal of the patient, and therefore medical imaging systems in common use today include an ECG port for inputting the ECG signal in order to gate the operation of the imaging system. However, since the ECG signal does not closely correlate with actual body movements during imaging of the patient's body or part thereof, the quality of the so-produced images is degraded by motion-generated artifacts. This is true with respect to body motions derived from both the respiratory activity and the cardiac activity of the patient.
Many techniques have been proposed using sensors for sensing such cardiac and respiratory body movements and to use the output of such sensors for gating or synchronizing the imaging system. For example, U.S. Pat. No. 4,945,916, discloses an optical sensor for this purpose; and more recent U.S. Pat. Nos. 6,721,386 and 6,771,999 disclose mechanical sensors for this purpose. U.S. Pat. No. 6,621,278, and International Application No. IL02/00983 published Jun. 12, 2003 as Publication No. WO03/048688, both assigned to the assignee of the present application, and the contents of which are expressly incorporated herein by reference, disclose mechanical-type sensors of extremely high sensitivity which are particularly useful for this purpose.
Such methods, however, generally use a predefined feature along the cardiac cycle, e.g., the onset of systole or of diastole, as reference points for gating the imaging system. Therefore they do not take into account Heart Rate Variability (HRV) when existing in the patient being imaged. When HRV exists, which is not an uncommon occurrence, the gating signal used for synchronizing the imaging system becomes un-correlated to actual body motions in the patient, such that body motions introduce significant artifacts which blur and degrade the images produced.
An object of the present invention is to provide a method of controlling a medical imaging system having advantages in the above respects, in that the method takes into account Heart Rate Variability (HRV) when existing in a patient. Another object of the present invention is to provide a control apparatus for controlling an imaging system in order to reduce the motion-generated artifacts produced by the imaging system, particularly when HRV exists. A further object of the present invention is to provide a medical imaging system capable of producing high-quality images with reduced motion-generated artifacts particularly when HRV exists in the patient.
According to one aspect of the present invention, there is provided a method of controlling an imaging system while imaging a patient's body or part thereof, comprising the steps: sensing a cyclically-occurring physiological condition of the patient over a plurality of cycles, and producing a sensor output signal corresponding thereto; analyzing the sensor output signal over the plurality of cycles to identify at least one time point of each cycle in which the sensor output signal exhibits a minimum deviation in the plurality of cycles; and utilizing the at least one time point of minimum deviation for gating the imaging system.
In the preferred embodiment of the invention described below, the sensing step senses a cyclically-occurring physiological movement of a portion of the patient's body. Particularly good results are obtainable when the sensor is of the displacement-type or accelerometer-type sensor described in the above-cited U.S. Pat. No. 6,621,278 or International Patent Application of Publication No. WO2004/0726578, assigned to the assignee of the present application the (contents of which have been incorporated herein by reference).
In the described preferred embodiment, the cyclically-occurring physiological movement sensed is a movement in the cardiac and/or respiratory system of the patient's body. Preferably, one or more time points of minimum deviation are identified by superimposing each cycle of the sensor output signal over the preceding cycles in the plurality of cycles, and detecting one or more time points of the superimposed cycles exhibiting minimum deviation.
In the described preferred embodiment, the one or more time points of minimum deviation are also used for enabling the imaging system in addition to gating the imaging system. After each time point of minimum deviation has been detected and utilized for enabling and gating the imaging system, the sensor output signal is continued to be analyzed and used for disabling the imaging system whenever the deviation of the respective time point falls outside a pre-selected tolerance limit.
The analysis may involve initially pre-selecting a plurality of initial time points of a cycle and analyzing the sensor output signal over the plurality of cycles to identify the initial time point of each cycle exhibiting a minimum deviation over the plurality of cycles. Alternatively, the analysis may involve pre-selecting a time point in a cycle, and analyzing the sensor output signal over a plurality of cycles until the pre-selected time point exhibits a predetermined minimum deviation over the plurality of cycles.
The invention is particularly useful where the imaging system includes a gating port for receiving an ECG gating signal since such a system already includes the various controls and the algorithms involved for controlling the operation of the imaging system, during both the data acquisition phase and the picture reconstruction phase. When the invention is used in such an imaging system, the identified time point or points, in which the sensor output signal exhibits a minimum deviation over the plurality of monitored cycles, are used for synthesizing a virtual ECG signal to be applied to the gating port of the imaging system for gating the imaging system.
In order to produce a gating signal which is more closely correlated to the actual body motions, two or more time points may be identified in the sensor output signal exhibiting a minimum deviation over the plurality of cycles, and may be used for synthesizing the virtual or ECG signal to be applied to the gating port of the imaging system for gating the imaging system. Thus, one such time point of minimum deviation may be used for generating a first segment of the virtual ECG signal, and one or more other time points of minimum deviation may be used for generating one or more other segments of the virtual ECG signal. Since the accumulated error in such a synthesized virtual ECG signal increases with time from the respective time point of minimum deviation, identifying two or more time points of minimum deviation, and using them for synthesizing the virtual ECG signal, reduces such an accumulated error.
According to another aspect of the present invention, there is provided control apparatus for an imaging system to be used for imaging a patient's body or part thereof, the control apparatus comprising: a sensor for sensing a cyclically-occurring physiological condition of the patient over a plurality of cycles, and for producing a sensor output signal corresponding thereto; and a processor designed to analyze the sensor output signal over the plurality of cycles to identify at least one time point of each cycle in which the sensor output signal exhibits a minimum deviation over the plurality of cycles, and to use the at least one time point of minimum deviation for gating the imaging system.
According to a further aspect of the present invention, there is provided an imaging system for imaging a patient's body, comprising: an imaging device for imaging the patient's body, and including a gating control for gating said imaging device in order to reduce motion-generated artifacts; a sensor for sensing a cyclically-occurring physiological condition of the patient over a plurality of cycles, and for producing a sensor output signal corresponding thereto; and a processor designed to analyze said sensor output signal over said plurality of cycles to identify at least one time point of each cycle in which the sensor output signal exhibits a minimum deviation in said plurality of cycles, and to use at least one time point of minimum deviation for gating said imaging device.
Further features and advantages of the invention will be apparent from the description below.
The invention is herein described, by way of example, with reference to the accompanying drawings, wherein:
a-4c illustrate examples of how two time points of minimum deviation in the MCG (mechano-cardiogram) signal may be selected for gating the imaging system, and the relationship of the selected time points to the ECG signal;
It is to be understood that the foregoing drawings, and the description below, are provided primarily for purposes of facilitating understanding the conceptual aspects of the invention and possible embodiments thereof, including what is presently considered to be a preferred embodiment. In the interest of clarity and brevity, no attempt is made to provide more details than necessary to enable one skilled in the art, using routine skill and design, to understand and practice the described invention. It is to be further understood that the embodiments described are for purposes of example only, and that the invention is capable of being embodied in other forms and applications than described herein.
With reference first to
In accordance with the present invention, the imaging system includes a processor, generally designated 5, which analyzes the output signal from sensor 4 over a plurality of cycles to identify one or more time points of each cycle in which the sensor output signal exhibits a minimum deviation in the plurality of cycles. The processor utilizes the so-identified one or more time points of each cycle of minimum deviation for gating the imaging system 2.
In the described preferred embodiment, imaging system 2 may be an existing MRI or CT imaging system designed to utilize the ECG signal of the patient for gating and synchronizing the operation of the imaging system. Thus, the imaging system 2 itself includes the appropriate algorithms and controls for controlling the operation of the imaging system both in the data acquisition phase, and also in the picture reconstruction phase. Such imaging systems therefore commonly include an ECG gating port, shown at 6 in
The apparatus illustrated in
As further shown in
While the synthesized ECG signal outputted from processor 5 is used for gating the imaging system 2, processor 5 continues to analyze the output signal of sensor 4 (block 14); and whenever it is found that the deviation of the selected time points exceeds a predetermined tolerance, the imaging system is disabled (block 15). Any data generated while the imaging system is disabled will therefore not be included in the data acquired by the imaging system during the data acquisition phase, or used for reconstructing the pictures in the picture reconstruction phase.
The basic flow chart illustrated in
For example, it may be desirable to limit the time point of each cycle to be used as the gating signal for gating the imaging system to one (or more) of a plurality of pre-selected time points.
For example, the upper signal illustrated in
Instead of monitoring a plurality of pre-selected time points in a cardiac cycle, to identify the time point of minimum deviation for use in synthesizing the virtual ECG signal to be used for gating the imaging system, a single time point may be pre-selected and monitored for a number of cycles. In this case, such a pre-selected time point would be used for gating the imaging system only when the pre-selected time point deviation is found to be within a predefined limit.
The foregoing will be better understood by reference to
The upper waveform illustrated in
It will also be appreciated that two or more time points could be identified in the sensor output signal for analysis and for use as gating pulses when the deviation of the respective time point over a plurality of monitored cycles falls within a predefined low range. As will be described more particularly below particularly with respect to
Monitor 8 in the apparatus of
As shown in
It will be seen that, in
Accordingly, processor 5 (
As indicated earlier, using a single time point for synthesizing the gating signal produces an accumulative error, namely an error which increases with time from the respective time point. In order to reduce this accumulative error, two or more time points may be determined each representing a minimum deviation of a part or segment of the cardiac cycle, and the two or more such determined time points may be used for synthesizing the virtual ECG wave used for gating the imaging system. For example, in the segment of the cardiac cycle represented by time point “m”, in a region in which there is a wide variation in the standard deviation as shown by curve “Y”, a point of minimum deviation may be selected in this segment of the cardiac cycle and used for synthesizing this segment of the virtual ECG wave used for gating the imaging system, such that the gating wave will include gating pulses at two (or more) time points of the cardiac cycle.
While the invention has been described with respect to one preferred embodiment, it will be appreciated that may variations and other applications of the invention may be made. For example, the sensor 4 could sense cyclically-occurring movements in the respiratory system, rather than in the cardiac system, of the patient's body for gating the imaging system Also, the imaging system could be an MRI system, a CT system, or one of the other known imaging systems. Where the imaging system is one exposing the patient to potentially harmful radiation, such as a CT system, the gating pulses could be used not only for enabling the imaging system with respect to the data-acquisition phase and the picture-reconstruction phase, but also for activating the radiation production in the system, so as to minimize the patient's exposure to such radiation. In addition, the monitored periods for determining time points of minimum deviation over a plurality of cycles could be a predetermined number of cycles (e.g. 10-30 cycles), or could be indefinite periods, extending until the monitored time point exhibits the desired minimum deviation, or exceeds a specified maximum deviation.
Many other variations, modifications and applications of the invention will be apparent.
Number | Date | Country | Kind |
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168424 | May 2005 | IL | national |