Patent Grant
11006742
The present disclosure is directed generally to methods and systems for providing feedback about a cleaning session to a user of an oral cleaning device.
Proper tooth brushing, including length and coverage of brushing, helps ensure long-term dental health. Many dental problems are experienced by individuals who either do not regularly brush their teeth or who do so inadequately, especially in a particular area or region of the oral cavity. Among individuals who do brush regularly, improper brushing habits can result in poor coverage of brushing and thus surfaces that are not adequately cleaned during a cleaning session, even when a standard brushing regimen, such as brushing for two minutes twice daily, is followed.
To facilitate proper brushing, it is important to ensure that there is adequate cleaning of all dental surfaces, including areas of the mouth that are hard to reach or that tend to be improperly cleaned during an average cleaning session. One way to ensure adequate coverage is to track the position of the toothbrush in the mouth during a cleaning session and compare that to a map of the dental surfaces. For example, a system with sensors positioned in fixed relationship to the teeth of the user could track the movement of a toothbrush over the user's teeth. Alternatively, the toothbrush could include one or more internal sensors that attempt to track movement of the device within the mouth. In such a system, the user starts with the toothbrush at a known, fixed position within the mouth and subsequent movement of the brush is determined from the one or more internal sensors.
However, this approach has several limitations. First, in order to be effective, the system must be able to adequately identify and track the regions of the mouth being brushed, which is challenging due to significant oral variation within a population. Second, while existing methods and devices may guide or direct a user's brushing activity during a timed cleaning session, the methods and devices are not able to detect the quality of the brushing activity during that cleaning session. Further, even if an inadequate cleaning session is detected, existing methods and devices are unable to correct the detected inadequacy.
Accordingly, there is a continued need in the art for methods and devices that provide feedback to a user based on an analysis of brushing data obtained during a cleaning session in order to detect and correct a cleaning session deficiency.
The present disclosure is directed to inventive methods and systems for providing feedback about a cleaning session to a user of an oral cleaning device. Applied to a system configured to provide a guided cleaning session, the inventive methods and systems enable tracking of a cleaning session and thus enable a detailed evaluation of the coverage and quality of a cleaning session. When the evaluation identifies inadequacies in the user's cleaning session or technique the system conveys that information to the user, and includes instructions for remedying the inadequacies. The instructions can include, for example, information about which regions of the mouth to brush and for how long. Accordingly, the system utilizes sensor data to monitor the cleaning session and detect areas where brushing is not optimal, and then guides the user through a secondary cleaning session that ensures an optimal brushing performance in all areas of the mouth.
Generally in one aspect, a method for providing feedback to a user of an oral cleaning device is provided. The method includes the steps of: receiving, from a sensor of the oral cleaning device, sensor data during a primary cleaning session; extracting, from the received data, information about one or more parameters of the primary cleaning session and evaluating, based on the extracted information, the primary cleaning session; determining, based on said evaluation, whether a secondary cleaning session is needed; and providing, via a user interface, an indication to the user that a secondary cleaning session is needed.
According to an embodiment, the one or more parameters is selected from the group consisting of the duration of the primary cleaning session, pressure applied during the primary cleaning session, the location of the oral cleaning device within the mouth during the primary cleaning session, an angle of the oral cleaning device during the primary cleaning session, and combinations thereof.
According to an embodiment, the determining step comprises the step of comparing the extracted information to a predetermined threshold.
According to an embodiment, the evaluation comprises an analysis of the extracted information using a set of one or more rules.
According to an embodiment, the indication comprises information about one or more segments of the user's mouth that requires additional cleaning during the secondary cleaning session, and/or an amount of additional cleaning time required for the one or more segments of the user's mouth that requires additional cleaning.
According to an embodiment, the method further includes the step of providing real-time feedback about the cleaning session to the user during the primary and/or secondary cleaning session.
According to an embodiment, the method further includes the step of receiving, from the sensor of the oral cleaning device, sensor data during the secondary cleaning session.
According to an aspect is an oral cleaning device configured to provide feedback to a user about a cleaning session. The device includes: a sensor configured to obtain data regarding a brushing session; a user interface configured to provide feedback to the user about the brushing session; and a controller in communication with the sensor and the user interface, wherein the controller is configured to: receive, from the sensor, sensor data during a primary cleaning session; extract, from the received data, information about one or more parameters of the primary cleaning session and evaluate, based on the extracted information, the primary cleaning session; determine, based on said evaluation, whether a secondary cleaning session is needed; and provide, via the user interface, an indication to the user that a secondary cleaning session is needed.
According to an embodiment, the sensor is one or more of a gyroscope, an accelerometer, and a magnetometer.
According to an aspect is an oral cleaning system configured to provide feedback to a user about a cleaning session. The system includes: an oral cleaning device comprising a sensor configured to obtain sensor data regarding a brushing session, and a connectivity module configured to transmit the obtained sensor data; and a remote device comprising a communications module configured to receive the transmitted sensor data, and a processor configured to: extract, from the received data, information about one or more parameters of the primary cleaning session and evaluate, based on the extracted information, the primary cleaning session; determine, based on said evaluation, whether a secondary cleaning session is needed; and provide an indication to the user that a secondary cleaning session is needed.
It should be appreciated that all combinations of the foregoing concepts and additional concepts discussed in greater detail below (provided such concepts are not mutually inconsistent) are contemplated as being part of the inventive subject matter disclosed herein. In particular, all combinations of claimed subject matter appearing at the end of this disclosure are contemplated as being part of the inventive subject matter disclosed herein.
These and other aspects of the invention will be apparent from and elucidated with reference to the embodiment(s) described hereinafter.
In the drawings, like reference characters generally refer to the same parts throughout the different views. Also, the drawings are not necessarily to scale, emphasis instead generally being placed upon illustrating the principles of the invention.
The present disclosure describes various embodiments of a method and device for providing feedback about a cleaning session to a user of an oral cleaning device. More generally, Applicant has recognized and appreciated that it would be beneficial to provide a system to track the movement of an oral cleaning device within the mouth in order to evaluate a user's cleaning session and provide feedback for a secondary cleaning session. Accordingly, the methods described or otherwise envisioned herein provide an oral cleaning device configured to evaluate a user's cleaning session, determine how long or how well the user brushes regions of the mouth among other variables, and provide information about a secondary cleaning session to the user. According to an embodiment, the oral cleaning device comprises one or more sensors to obtain data utilized to evaluate the user's cleaning session, and comprises a feedback mechanism to guide the user through a secondary cleaning session in order to achieve an optimal cleaning session.
The embodiments and implementations disclosed or otherwise envisioned herein can be utilized with any oral device, including but not limited to a toothbrush, a flossing device such as a Philips AirFloss®, an oral irrigator, or any other oral device. One particular goal of utilization of the embodiments and implementations herein is to provide brushing information and feedback using an oral cleaning device such as, e.g., a Philips Sonicare® toothbrush (manufactured by Koninklijke Philips Electronics, N.V.). However, the disclosure is not limited to a toothbrush and thus the disclosure and embodiments disclosed herein can encompass any oral device.
Referring to
According to an embodiment, head member 14, brush head 16, and/or bristle face 18 are mounted so as to be able to move relative to the body portion 12. The movement can be any of a variety of different movements, including vibrations or rotation, among others. According to one embodiment, head member 14 is mounted to the body so as to be able to vibrate relative to body portion 12, or, as another example, brush head 16 is mounted to head member 14 so as to be able to vibrate relative to body portion 12. The head member 14 can be fixedly mounted onto body portion 12, or it may alternatively be detachably mounted so that head member 14 can be replaced with a new one when the bristles or another component of the device are worn out and require replacement.
According to an embodiment, body portion 12 includes a drivetrain 22 for generating movement and a transmission component 24 for transmitting the generated movements to brush head member 14. For example, drivetrain 22 can comprise a motor or electromagnet(s) that generates movement of the transmission component 24, which is subsequently transmitted to the brush head member 14. Drivetrain 22 can include components such as a power supply, an oscillator, and one or more electromagnets, among other components. In this embodiment the power supply comprises one or more rechargeable batteries, not shown, which can, for example, be electrically charged in a charging holder in which oral cleaning device 10 is placed when not in use.
Although in the present embodiment the oral cleaning device 10 is an electric toothbrush, it will be understood that in an alternative embodiment the oral cleaning device is a manual toothbrush (not shown). In such an arrangement, the manual toothbrush has electrical components, but the brush head is not mechanically actuated by an electrical component.
Body portion 12 is further provided with a user input 26 to activate and de-activate movement generator 22. The user input 26 allows a user to operate the toothbrush 20, for example to turn the toothbrush 20 on and off. The user input 26 may, for example, be a button, touch screen, or switch.
The oral cleaning device 10 includes one or more sensors 28. Sensor 28 is shown in
According to an embodiment, sensor 28 is configured to generate information indicative of the acceleration and angular orientation of the oral cleaning device 10. For example, the sensor system may comprise two or more sensors 28 that function together as a 6-axis or a 9-axis spatial sensor system. According to another embodiment, an integrated 9-axis spatial sensor can provide space savings in an oral cleaning device 10.
The information generated by the first sensor 28 is provided to a controller 30. Controller 30 may be formed of one or multiple modules, and is configured to operate the oral cleaning device 10 in response to an input, such as input obtained via user input 26. According to an embodiment, the sensor 28 is integral to the controller 30. Controller 30 can comprise, for example, at least a processor 32, a memory 34, and a connectivity module 38. The processor 32 may take any suitable form, including but not limited to a microcontroller, multiple microcontrollers, circuitry, a single processor, or plural processors. The memory 34 can take any suitable form, including a non-volatile memory and/or RAM. The non-volatile memory may include read only memory (ROM), a hard disk drive (HDD), or a solid state drive (SSD). The memory can store, among other things, an operating system. The RANI is used by the processor for the temporary storage of data. According to an embodiment, an operating system may contain code which, when executed by controller 30, controls operation of the hardware components of oral cleaning device 10. According to an embodiment, connectivity module 38 transmits collected sensor data, and can be any module, device, or means capable of transmitting a wired or wireless signal, including but not limited to a Wi-Fi, Bluetooth, near field communication, and/or cellular module.
According to an embodiment, oral cleaning device 10 includes a user interface 46 configured to provide information to a user before, during, and/or after a primary cleaning session, and before, during, and/or after a secondary cleaning session. The user interface 46 can take many different forms, but is configured to provide information to a user. For example, the information can be read, viewed, heard, felt, and/or otherwise interpreted concerning where, when, and/or how to brush particular sections, segments, or areas of the interior of the mouth. According to an embodiment, the user interface 46 provides feedback to the user, such as a guided cleaning session, that includes information about where within the mouth to brush, timing, angles, pressure, and/or a variety of other brushing parameters or characteristics. Accordingly, the user interface may be a display that provides information to the user, a haptic mechanism that provides haptic feedback to the user, a speaker to provide sounds or words to the user, or any of a variety of other user interface mechanisms. According to an embodiment, controller 30 of oral cleaning device 10 receives information from sensor 28, assesses and analyzes that information, and provides information that can be displayed to the user via the user interface 46.
Referring to
According to an embodiment, remote device 40 can be any device configured to or capable of receiving and processing sensor information transmitted from oral cleaning device 10. For example, remote device 40 may be a cleaning device holder or station, a smartphone device, a computer, a tablet, a server, or any other computerized device. According to an embodiment, remote device 40 includes a communications module 41 which can be any module, device, or means capable of receiving a wired or wireless signal, including but not limited to a Wi-Fi, Bluetooth, near field communication, and/or cellular module. Device 40 also includes a processor 42 which uses the received information from sensor 28 sent via connectivity module 38. According to an embodiment, device 40 includes memory 44 to store received sensor information, or any other information.
According to an embodiment, remote device 40 includes a user interface 46 configured to provide feedback to the user before, during, and/or after a primary cleaning session, and before, during, and/or after a secondary cleaning session. The user interface 46 can take many different forms, but is configured to provide information to a user. For example, the information can be read, viewed, heard, felt, and/or otherwise interpreted concerning where, when, and/or how to brush particular sections, segments, or areas of the interior of the mouth. According to an embodiment, the user interface 46 provides feedback to the user, such as a guided cleaning session, that includes information about where within the mouth to brush, timing, angles, pressure, and/or a variety of other brushing parameters or characteristics. Accordingly, the user interface may be a display that provides information to the user, a haptic mechanism that provides haptic feedback to the user, a speaker to provide sounds or words to the user, or any of a variety of other user interface mechanisms. According to an embodiment, processor 42 of remote device 40 receives information from sensor 28 of the oral cleaning device via the connectivity modules, assesses and analyzes that information, and provides information that can be displayed to the user via the user interface 46.
For example, oral cleaning device 10 can collect sensor information using sensor 28 and transmit that information locally via a Bluetooth connection to a smartphone device 40, where the sensor information is processed and/or stored. As another example, oral cleaning device 10 can collect sensor information using sensor 28 and transmit that information via a WiFi connection to the Internet where it is communicated to a remote server device 40. The remote server device 40 processes and/or stores the sensor information. A user may access that information directly or may receive reports, updates, or other information from the remote server device 40 or an associated device. According to an embodiment, the remote device 40 includes a user interface 46 configured to display instructions to the user during the cleaning session and/or “touch-up” session. The user interface 46 can take various forms, but will provide instructions to the user that can be read, viewed, heard, felt, and/or otherwise interpreted concerning where, when and how to brush particular sections, segments, or areas of the interior of the mouth. The processor 42 of remote device 40 processes the information received from the sensor(s) 28, assesses and analyzes that information, and provides information that can be displayed to the user via the user interface 46.
Referring to
According to an embodiment of oral cleaning system 200, at sensor detection step or module 210, the sensor 28 of the oral cleaning device 10 obtains sensor data about a cleaning session. The obtained data is then optionally transmitted, via connectivity module 38, to remote device 40 at sensor data transmission step or module 220. In an embodiment without a remote device 40, the sensor data is utilized in downstream steps by the oral cleaning device 10.
A feature extraction module 230 receives data about the oral cleaning session from sensor 28, extracts the relevant information, and performs an assessment and/or analysis thereof. According to an embodiment, data including brushing coverage such as teeth areas cleaned, pressure coverage, and brushing duration is extracted from the data transmitted from sensor 28. Feature extraction module 230 can be configured to extract information about the orientation, angle, and/or location of the oral cleaning device from sensor 28, and can perform an analysis of the sensor data using any of a variety of analyze methods, including but not limited to a discrete cosine matrix method or a Kalman filter. That data can be compared, for example, to a predefined, predetermined, and/or personalized set of thresholds representative of the user's oral cavity.
According to another embodiment, feature extraction module 230 extracts the position of the oral cleaning device 10 by means of statistical analysis, such as by use of a Hidden Markov Model, which be pre-trained on a dedicated data set, can be user-specific based on data obtained during one or more training sessions, or can be a combination of both types of data. In yet another embodiment, sensor 28 is an electromagnetic sensor, and feature extraction module 230 extracts information regarding the proximity of a specific body part with respect to oral cleaning device 10. This can improve the accuracy of coverage measurements and can reduce ambiguity in orientation and/or position estimates. According to another embodiment, additional feature extraction can occur, including the detection of caries, demineralization, gingivitis, or other oral health conditions or traits. These conditions or traits can be extracted and/or identified using one or more dedicated sensing modalities, either embedded in the oral cleaning device 10, or a portion thereof. The spatial resolution of these features is provided by linking their detection with the extracted coverage information.
According to an embodiment of oral cleaning system 200, a performance assessment module 240 can analyze the extracted feature information. For example, the performance assessment module 240 can analyze the extracted feature information using a set of rules. These rules can be, for example, pre-defined or predetermined or can be personalized by or to the user or a dental care professional. According to an embodiment, the rules can be applied at a global scale, such as the entire mouth, or locally, such as a mouth segment or quadrant, or on the scale of individual teeth.
According to one embodiment, the rules are based on: (i) a required time spent in one or multiple part of a user's mouth, such as brushing every tooth surface located within a teeth segment for at least 20 seconds, brushing along the gum lines for a minimum of six seconds, and so on; and/or (ii) a required force applied in one or multiple locations within a user's mouth, such as a minimum force of 150 grams applied along the gum lines; and/or (iii) detection of an oral health condition, such as mild gingivitis detected in one or multiple interdental space. For example, Typical rules can, for example, identical or similar to Equations 1 and 2, although many other rules and equations are possible:
The performance assessment module 240 can then provide the results of the analysis to user interface 46 through decision module: secondary session 250.
Referring to
Referring to
Returning to
According to an embodiment, if the user elects to perform the secondary cleaning session 260 oral cleaning device 10 is configured to perform one or more tasks related to that secondary cleaning session. For example, if too little force was used in a specific area during the primary cleaning session, the oral cleaning system 100, upon detecting that the oral cleaning device 10 is located in that portion of the oral cavity based on input from sensor 28, can implement an operating mode that applies greater pressure. When the oral cleaning system 100 detects that the oral cleaning device 10 has been moved away from that particular area of the oral cavity, the system can direct the oral cleaning device 10 to implement an operating mode that applies a standard amount of pressure, as brushing is being performed in an area where the user typically provides sufficient brushing pressure. Similarly, if too little time was spent cleaning a specific area, oral cleaning device 10 can provide information to the user, such as in
According to an embodiment, when the secondary cleaning session has been completed, decision module 250 can: (1) provide feedback to a user indicating that the secondary cleaning session was successful and the user's teeth are clean, as shown in
Referring to
In step 320 of the method, the user engages in a cleaning session and the sensor 28 obtains data about the cleaning session, including but not limited to location of brushing, duration of brushing, and pressure of brushing. Device controller 30 receives the data from the sensor. According to an embodiment, device controller 30 transmits the data collected from sensor 28 to remote device 40 via connectivity module 38.
At step 330 of the method, device controller 30 and/or remote processor 42 analyzes the sensor data to extract and evaluate information about the user's cleaning session, as described above with regard to performance assessment module 240. For example, performance assessment module 240 can analyze the extracted information and evaluate the data using a set of rules. These rules can be, for example, pre-defined or predetermined or can be personalized by or to the user or a dental care professional. According to an embodiment, the rules can rules can be applied at a global scale, such as the entire mouth, or locally, such as a mouth segment or quadrant, or on the scale of individual teeth. For example, the rules can be based on: (i) a required time spent in one or multiple part of a user's mouth, such as brushing every tooth surface located within a teeth segment for at least 20 seconds, brushing along the gum lines for a minimum of six seconds, and so on; and/or (ii) a required force applied in one or multiple locations within a user's mouth, such as a minimum force of 150 grams applied along the gum lines; and/or (iii) detection of an oral health condition, such as mild gingivitis detected in one or multiple interdental space.
At optional step 335 of the method, during a cleaning session the oral cleaning device 10 and/or the remote device 40 provides instructions and/or feedback to the user during the cleaning session, such as shown in
At step 340 of the method, the oral cleaning device 10, system 100, and/or remote device 40 determines whether a supplemental cleaning session is needed. For example, device controller 30 and/or remote processor 42 can evaluate a portion or the entirety of a brushing session and can determine whether a supplemental cleaning session is needed. For example, as described herein, decision module 250, which may be device controller 30 and/or remote processor 42, a component of device controller 30 and/or remote processor 42, or software run with device controller 30 and/or remote processor 42, receives information from performance assessment module 240 during and/or after the cleaning session. Decision module 250 is configured to analyze the information received from performance assessment module 240 in order to determine whether a secondary cleaning session is warranted or necessary. Accordingly, decision module 250 can: (1) provide feedback 270 to the user indicating that the primary cleaning session was adequate, as shown in
For example, after a cleaning session is completed, the decision module 250 analyzes the received information and determines whether the user's actions have satisfied a predefined or predetermined threshold. If the user strictly adhered to guided brushing instructions, for example, it is expected that a secondary cleaning session will not be necessary. However, research has shown that most users do not clean for a full two-minute recommended session, do not brush all areas of the mouth for the recommended time duration, do not brush at the proper angle, and/or do not apply the appropriate pressure in all areas of the mouth, even with guided brushing instructions. Based on the analysis performed by decision module 106 of the current cleaning session from data received by the sensors 28, a determination of achieved optimal brushing performance can be made.
If the cleaning session executed by the user satisfies the predetermined threshold, then the method proceeds to step 370, and the user receives information via user interface 46 that the primary cleaning session was adequate, as shown in
If the cleaning session executed by the user fails to satisfy the predetermined threshold, then the method proceeds to step 350, and the user receives information via user interface 46 that the primary cleaning session was inadequate and thus that a secondary cleaning session is necessary. As shown in
Feedback generated by oral cleaning device 10, system 100, and/or remote device 40 can be provided to the user in any of a variety of different ways, including via visual, written, audible, haptic, or other types of feedback. For example, completion of a satisfactory brushing routine could be by means of audio, haptic or other signals, such as a positive signal or song.
At step 360 of the method, if the user elects to perform the secondary cleaning session 365 user interface 46 of the oral cleaning device 10 and/or remote device 40 can optically guide the user through secondary cleaning session 365 directing the user to areas needing additional cleaning, providing the user information on how long to perform additional cleaning in each area, and other information, and sensor 28 of the oral cleaning device will collect sensor data indicative of the cleaning session. For example, sensor 28 can obtain any of the data described herein, including but not limited to location of brushing, duration of brushing, and pressure of brushing. Device controller 30 receives the data from the sensor. According to an embodiment, device controller 30 transmits the data collected from sensor 28 to remote device 40 via connectivity module 38. The device controller 30 and/or remote processor 42 analyzes the sensor data to extract and evaluate information about the user's cleaning session, as described above with regard to performance assessment module 240.
At step 365 of the method, the system returns to step 340 and the oral cleaning device 10, system 100, and/or remote device 40 analyzes the sensor data received during the secondary cleaning session to determine whether a tertiary cleaning session is needed, using any of the methods described or otherwise envisioned herein. If a tertiary cleaning session is needed, the system proceeds to step 350. If the secondary cleaning session adequately resolved any issues, to the user receives feedback indicating that the secondary cleaning session was adequate, as shown in
All definitions, as defined and used herein, should be understood to control over dictionary definitions, definitions in documents incorporated by reference, and/or ordinary meanings of the defined terms.
The indefinite articles “a” and “an,” as used herein in the specification and in the claims, unless clearly indicated to the contrary, should be understood to mean “at least one.”
The phrase “and/or,” as used herein in the specification and in the claims, should be understood to mean “either or both” of the elements so conjoined, i.e., elements that are conjunctively present in some cases and disjunctively present in other cases. Multiple elements listed with “and/or” should be construed in the same fashion, i.e., “one or more” of the elements so conjoined. Other elements may optionally be present other than the elements specifically identified by the “and/or” clause, whether related or unrelated to those elements specifically identified.
As used herein in the specification and in the claims, “or” should be understood to have the same meaning as “and/or” as defined above. For example, when separating items in a list, “or” or “and/or” shall be interpreted as being inclusive, i.e., the inclusion of at least one, but also including more than one, of a number or list of elements, and, optionally, additional unlisted items. Only terms clearly indicated to the contrary, such as “only one of” or “exactly one of,” or, when used in the claims, “consisting of,” will refer to the inclusion of exactly one element of a number or list of elements. In general, the term “or” as used herein shall only be interpreted as indicating exclusive alternatives (i.e. “one or the other but not both”) when preceded by terms of exclusivity, such as “either,” “one of,” “only one of,” or “exactly one of.”
As used herein in the specification and in the claims, the phrase “at least one,” in reference to a list of one or more elements, should be understood to mean at least one element selected from any one or more of the elements in the list of elements, but not necessarily including at least one of each and every element specifically listed within the list of elements and not excluding any combinations of elements in the list of elements. This definition also allows that elements may optionally be present other than the elements specifically identified within the list of elements to which the phrase “at least one” refers, whether related or unrelated to those elements specifically identified.
It should also be understood that, unless clearly indicated to the contrary, in any methods claimed herein that include more than one step or act, the order of the steps or acts of the method is not necessarily limited to the order in which the steps or acts of the method are recited.
In the claims, as well as in the specification above, all transitional phrases such as “comprising,” “including,” “carrying,” “having,” “containing,” “involving,” “holding,” “composed of,” and the like are to be understood to be open-ended, i.e., to mean including but not limited to. Only the transitional phrases “consisting of” and “consisting essentially of” shall be closed or semi-closed transitional phrases, respectively.
While several inventive embodiments have been described and illustrated herein, those of ordinary skill in the art will readily envision a variety of other means and/or structures for performing the function and/or obtaining the results and/or one or more of the advantages described herein, and each of such variations and/or modifications is deemed to be within the scope of the inventive embodiments described herein. More generally, those skilled in the art will readily appreciate that all parameters, dimensions, materials, and configurations described herein are meant to be exemplary and that the actual parameters, dimensions, materials, and/or configurations will depend upon the specific application or applications for which the inventive teachings is/are used. Those skilled in the art will recognize, or be able to ascertain using no more than routine experimentation, many equivalents to the specific inventive embodiments described herein. It is, therefore, to be understood that the foregoing embodiments are presented by way of example only and that, within the scope of the appended claims and equivalents thereto, inventive embodiments may be practiced otherwise than as specifically described and claimed. Inventive embodiments of the present disclosure are directed to each individual feature, system, article, material, kit, and/or method described herein. In addition, any combination of two or more such features, systems, articles, materials, kits, and/or methods, if such features, systems, articles, materials, kits, and/or methods are not mutually inconsistent, is included within the inventive scope of the present disclosure.
This application is the U.S. National Phase application under 35 U.S.C. § 371 of International Application No. PCT/IB2017/050941, filed on Feb. 20, 2017, which claims the benefit of U.S. Provisional Patent Application No. 62/350,906, filed on Jun. 16, 2016 and U.S. Provisional Patent Application No. 62/299,635 filed on Feb. 25, 2016. These applications are hereby incorporated by reference herein.
| Filing Document | Filing Date | Country | Kind |
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| PCT/IB2017/050941 | 2/20/2017 | WO | 00 |
| Publishing Document | Publishing Date | Country | Kind |
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| WO2017/145033 | 8/31/2017 | WO | A |
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