Claims
- 1. A method for alleviating angiotensin related hypertension in hypertensive mammals which comprises administering to said mammals an effective dose of an angiotensin converting enzyme inhibitor having the formula ##STR12## or salt thereof, wherein R.sub.1 is imidazolyl-lower alkylene or indolyl-lower alkylene R.sub.2, R.sub.3 and R.sub.4 each is hydrogen, lower alkyl or phenyl-lower alkylene;
- R.sub.5 is hydrogen, lower alkanoyl, benzoyl or ##STR13## n is 0, 1 or 2.
- 2. A method as in claim 1 wherein the compound has the L-configuration with respect to the carbon bearing R.sub.1.
- 3. A method as in claim 1 wherein in the formula the group ##STR14## is derived from an amino acid of the group consisting of histidine and tryptophane.
- 4. A method as in claim 1 wherein the dosage is about 10 to 500 mg. per kilogram per day.
- 5. A method as in claim 1 wherein the compound in the formula has R.sub.1 as 3-indolylmethyl, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 each as hydrogen and n as 1 and has the name N-(3-mercaptopropanoyl)-L-tryptophane.
- 6. A method as in claim 1 wherein the compound in the formula has R.sub.1 as 3-indolylmethyl, R.sub.2, R.sub.4 and R.sub.5 each as hydrogen, R.sub.3 as methyl and n as 1 and has the name N-(3-mercapto-2-methylpropanoyl)-L-tryptophane.
- 7. A method as in claim 1 wherein the compound in the formula has R.sub.1 as 4-imidazolylmethyl, R.sub.2, R.sub.3 and R.sub.5 each as hydrogen and n as 0 and has the name N-2-mercaptoacetyl-L-histidine.
- 8. A method as in claim 1 wherein the compound in the formula has R as 3-indolylmethyl, R.sub.2, R.sub.3 and R.sub.5 each as hydrogen and n as 0 and has the name N-2-mercaptoacetyl-L-tryptophane.
- 9. A method as in claim 1 wherein the compound in the formula has R.sub.1 as 4-imidazolylmethyl, R.sub.2 and R.sub.5 as hydrogen, R.sub.3 as methyl and n as 0 and has the name N-2-mercaptopropanoyl-L-histidine.
- 10. A method as in claim 1 wherein the compound in the formula has R.sub.1 as 3-indolylmethyl, R.sub.2 and R.sub.5 as hydrogen, R.sub.3 as methyl and n as 0 and has the name N-2-mercaptopropanoyl-L-tryptophane.
Parent Case Info
This application is a division of application Ser. No. 773,865 filed Mar. 3, 1977 now U.S. Pat. No. 4,112,119, which in turn is a division of application Ser. No. 684,606, filed May 10, 1976, now U.S. Pat. No. 4,053,651, Oct. 11, 1977.
US Referenced Citations (3)
Number |
Name |
Date |
Kind |
3246025 |
Meta et al. |
Apr 1966 |
|
3857951 |
Buret |
Dec 1974 |
|
4053651 |
Ondetti et al. |
Oct 1977 |
|
Divisions (2)
|
Number |
Date |
Country |
Parent |
773865 |
Mar 1977 |
|
Parent |
684606 |
May 1976 |
|