Claims
- 1. A method for alleviating angiotensin related hypertension in hypertensive mammals which comprises administering to said mammals an effective dose of an angiotensin converting enzyme inhibitor having the formula ##STR12## or salt thereof, wherein R.sub.1 is carbamoyl-lower alkylene;
- R.sub.2, r.sub.3 and R.sub.4 each is hydrogen, lower alkyl or phenyl-lower alkylene;
- R.sub.5 is hydrogen, lower alkanoyl, benzoyl or ##STR13## n is 0, 1 or 2.
- 2. A method as in claim 1 wherein the compound has the L-configuration with respect to the carbon bearing R.sub.1.
- 3. A method as in claim 1 wherein in the formula the group ##STR14## is derived from the amino acid asparagine.
- 4. A method as in claim 1 wherein the dosage is about 10 to 500 mg. per kilogram per day.
- 5. A method as in claim 2 wherein the compound in the formula has R.sub.1 as carbamoylmethyl, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 each as hydrogen and n as 1.
- 6. A method as in claim 2 wherein the compound in the formula has R.sub.1 as carbamoylmethyl, R.sub.2, R.sub.3 and R.sub.5 each as hydrogen and n as 0.
Parent Case Info
This application is a division of application Ser. No. 773,865, filed Mar. 3, 1977 now U.S. Pat. No. 4,112,119, which in turn is a division of application Ser. No. 684,606, filed May 10, 1976, now U.S. Pat. No. 4,053,651, Oct. 11, 1977.
US Referenced Citations (3)
Number |
Name |
Date |
Kind |
3246025 |
Meta et al. |
Apr 1966 |
|
3857951 |
Buret |
Dec 1974 |
|
4053651 |
Ondetti et al. |
Oct 1977 |
|
Divisions (2)
|
Number |
Date |
Country |
Parent |
773865 |
Mar 1977 |
|
Parent |
684606 |
May 1976 |
|