Claims
- 1. A method for treating the surface of a medical device comprising:
(a) forming a medical device from a material comprising monomeric units having reactive functionalities selected from the group consisting of azlactone, carboxylic acid, amine, hydroxy and epoxy functionalities, and combinations thereof; (b) forming a hydrophilic reactive polymer having complementary reactive functionalities along the polymer chain selected from the group comprising azlactone, isocyanate, acid anhydride, epoxy, hydroxy, primary or secondary amine, or carboxylic acid functionalities, and combinations thereof, wherein in the case of the hydroxy or amine complementary reactive functionalities, the material comprises azlactone reactive functionalities and in the case of the carboxylic acid complementary functionality, the material comprises epoxy reactive functionalities; (c) reacting the hydrophilic reactive polymer of (b) having complementary reactive functionalities along the polymer chain with said reactive functionalities on or near the surface of the medical device of (a), at a reaction temperature at least sufficient to maintain the reactants in solution and less than 55° C., thus forming a biocompatible surface on the medical device; (d) removing the biocompatible surface of step (c); and (e) repeating steps (b) and (c) to form a renewed biocompatible surface on said medical device having properties substantially similar to the original biocompatible surface of step (c).
- 2. The method of claim 1, wherein the medical device is a silicone contact lens or intraocular lens and the coating is uncolored.
- 3. The method of claim 1, wherein the medical device is a silicone hydrogel, continuous-wear contact lens.
- 4. The method of claim 1, wherein the hydrophilic reactive polymer comprises 1 to 100 mole percent of monomeric units having said reactive functionalities.
- 5. The method of claim 1, wherein the hydrophilic reactive polymer comprises 0 to 99 mole percent of monomeric units that are derived from non-reactive hydrophilic monomers.
- 6. The method of claim 1, wherein the polymer comprises 50 to 95 mole percent of monomeric units derived from non-reactive hydrophilic monomers selected from the group consisting of acrylamides, lactones, poly(alkylenepoxy)methacrylates, methacrylic acid or hydroxyalkyl methacrylates and 5 to 50 percent of monomeric units derived from functionally reactive monomers selected from the group consisting of epoxy, azlactone, and anhydride containing monomers, wherein the alkyl or alkylene groups have 1 to 6 carbon atoms.
- 7. The method of claim 1, wherein the functionally reactive monomers are selected from the group consisting of glycidyl methacrylate, maleic anhydride, itaconic anhydride, and isocyanomethacrylate.
- 8. The method of claim 1, wherein the hydrophilic monomers are selected from the group consisting of dimethylacrylamide, acrylamide, N-vinyl pyrrolidinone methacrylic acid.
- 9. The method of claim 1, wherein the hydrophilic reactive polymer comprises 0 to 35 mole percent monomeric units derived from hydrophobic monomers.
- 10. The method of claim 1, wherein the hydrophilic polymer comprises oxazolinone moieties having the following formula:
- 11. The method of claim 10, wherein the polymer comprises the reaction product of a mixture of monomers comprising the monomer represented by the general formula:
- 12. The method of claim 11, wherein the monomer is selected from the group consisting of 2-vinyl-4, 4-dimethyl-2-oxazolin-5-one; 2-isopropenyl-4,4-dimethyl-2-oxazolin-5-one; 2-isopropenyl-4 ,4-dimethyl-2-oxazolin-5-one; and 2-vinyl-4,4-dimethyl-2-oxazol in-5-one.
- 13. The method of claim 10, wherein the medical device is dipped in a solution comprising at least one hydrophilic reactive polymer in the absence of a coloring substance.
- 14. The method of claim 1 wherein said removing step (d) further comprises abrading said biocompatible surface.
- 15. The method of claim 3 wherein said removing step (d) further comprises abrading said biocompatible surface with an abrasive particulate in an aqueous carrier solution.
- 16. The method of claim 15 wherein said abrasive particulate comprises silica or alumina.
- 17. The method of claim 1 wherein said reaction temperature is from about 15 to about 45° C.
- 18. The method of claim 17 where in said reaction temperature is from about 20 to about 40° C.
- 19. The method of claim 18 wherein said reaction temperature is approximately ambient temperature.
CROSS-REFERENCE TO RELATED APPLICATIONS
[0001] This application is related by subject matter to commonly-assigned U.S. application Ser. No. 09/315,620, filed May 20, 1999, and application Ser. No. 09/541,588, filed Apr. 3, 2000.
Continuations (1)
|
Number |
Date |
Country |
Parent |
09665355 |
Sep 2000 |
US |
Child |
10128172 |
Apr 2002 |
US |