Patent Application
20160135889
The proposed invention relates to a new improved melanin-enhanced photothermolysis hair removal method for white, blond or gray hair applicable to the beauty and photoepilation salon industry.
The fundamental principle of laser hair removal is selective photothermolysis (SPTL), the coincidence of a specific wavelength of light and a duration of impulses such as to obtain an optimum effect on a chosen tissue with a minimum effect on the surrounding tissue. Lasers can cause localized damage on selectively heating dark target matter, melanin, in the area that causes hair growth, the follicle, while not heating the rest of the skin. The light is absorbed by the dark objects so that the laser energy may be absorbed by dark skin matter, but with much greater speed and intensity. This dark target matter, or chromophore, may be natural or may be introduced artificially.
Melanin is considered to be the main chromophore for laser hair removal. Melanin occurs naturally in the skin and gives skin and hair their color. There are two types of melanin in hair. Eumelanin gives hair its chestnut or brown color, while pheomelanin gives hair its blond or red color. Due to the selective absorption of laser light photons, only black or chestnut hair can be removed. Laser works best with thick brown hair. Fair skin and brown hair are an ideal combination, being the most effective and producing the best results, but the new lasers are now capable of targeting dark brown hair with some success in dark-skinned patients.
The new lasers can target hair with little or no melanin by applying liposome-encapsulated artificial melanin solutions onto the skin, which is only accumulated in the hair and its follicle. In this manner, even patients with lighter-colored hair can remove unwanted hair using laser or IPL (Intense Pulsed Light) devices. The idea of selective staining of follicles of blond, white and gray hair could be an excellent approach to permanent laser hair removal.
Liposomal melanin lotions have been used in recent years with conflicting results.
In this connection, mention should be made of the pre-existence of U.S. Pat. No. 5,766,214 (Thomas L. Mehl and Nardo Zaias), where reference is made to the foregoing, through the topical application of liposome-encapsulated melanin to darken the hair follicles before subjecting the skin to photoepilation.
The main drawback of this method is that the patient must apply the melanin preparation six to eight times a day, two to five weeks prior to photoepilation, in order to allow absorption by the hair follicles. Successful hair removal was proportional to the amount of solution applied, i.e. the application of greater amounts of product leads to greater hair removal but with a higher cost.
Recently, the use of dermal puncture has been proposed as a new physical strategy for increasing the transdermal application of drugs. Since 1995, this technique has been used to achieve percutaneous collagen induction aimed at reducing skin imperfections [References 28 and 29]. To date, dermal puncture has been proposed mainly as an effective method for treating scars and wrinkles [References 30 and 31], and is carried out by rolling a special device over the skin which comprises a rotating body having a variable number of microneedles.
These types of devices are disclosed in patents WO0249711 (Horst LIEBL) and EP1764129 (Horst LIEBL).
The improved melanin-enhanced photothermolysis hair removal method proposed by the invention consists of an improved method of applying artificial melanin for the permanent removal of white, gray and blond hair based on the use of light energy that is absorbed by topically applied artificial melanin granules, resulting in death of the hair-producing tissue.
This method reduces the application time for introducing artificial melanin in the hair follicle and the amount of product required to induce hair removal.
Liposome-encapsulated artificial melanin penetrates in greater amounts and more quickly through the skin using a roller device having microneedles.
After the liposomal melanin solution is applied onto the skin, the roller is made to roll over the skin. In this case the needles penetrate the skin, opening micro-channels wherethrough melanin penetrates through the epidermis until reaching the hair follicle.
In such cases, this artificial melanin in the hair follicle is the chromophore for the selective photothermolysis of unwanted non-pigmented hair. Since the channels in the skin remain open for a long time, additional melanin can penetrate through the skin. Optionally, this method can be enhanced by means of a massage or similar measures.
Depending on the frequency with which the device moves over the skin, the number of channels opened therein may be specifically controlled, in addition to the degree to which the melanin can penetrate through the treated skin. Since the opened channels close again after a few minutes, damage to the epidermis is minimal. Therefore, the initially mentioned damage related to the removal of the epidermis does not occur in the case of the invention. In any case, light reddening of the skin is observed which, however, subsides completely in a few days, in most cases in one or two days. Therefore, the skin treatment practically has no side-effects and, in general, is completely painless.
Another advantage consists of the fact that the time required for the product to penetrate through the skin (hair follicle) and also the amount of product used may be considerably reduced, since the penetration of the ingredient through the lower skin layers is highly effective. All this simplifies and cheapens the method.
In order to supplement this specification and aid understanding thereof, the following drawings have been included:
In a preferred embodiment of the invention, the method is carried out using a liposomal sepia melanin solution, due to its resemblance to human melanin, as follows:
Twenty patients were treated with microneedle rollers to produce a dermal puncture every 3 minutes combined with a liposomal melanin solution on one side of the arm and only with a melanin solution on the other side, and the result was evaluated.
The side that received combined treatment (dermal puncture+melanin solution) showed a statistically significant reduction in comparison with the side treated only with a melanin solution and the clinical symptoms improved significantly.
This study suggests the potential use of combining dermal puncture with rollers and microneedles with a liposomal melanin solution to achieve better results in laser hair removal treatments for white, gray and blond hair.
Granular clusters of a brownish color in the stratum basale at intracellular level. These brownish-black deposits can be observed scattered throughout the papillary dermis. The post-laser biopsy reveals microvascular lesions (areas with extravasation of blood from capillaries) in the papillary dermis. Differences with regard to application with a roller and microneedles and without a roller can be observed. With a roller and microneedles the pigment is deeper and reaches the papillary dermis.
De Leeuw J, De Viljder H C, Bjerring P, Neumann H A. Liposomes in dermatology today. J Eur Acad Dermatol Venereol 2009; 23(5):505-16.
[30] G. Fabbrocini, N. Fardella, A. Monfrecola, I. Proietti, and D. Innocenzi, “Acne scarring treatment using skin needling,” Clinical and Experimental Dermatology, vol. 34, no. 8, pp. 874-879, 2009.
| Filing Document | Filing Date | Country | Kind |
|---|---|---|---|
| PCT/ES2013/070088 | 5/7/2013 | WO | 00 |
