Sawada et al, Jan. 1992. Immunoglobulins from amyotrophic lateral sclerosis (ALS) patients interact with a related muscle DHP-sensitive L-type Ca.sup.2+ channels, FASEB J 6(1):A401, Abstract #2313. |
Smith et al, Dec. 1992. Serum antibodies to L-type calcium channels in patients with amyotrophic lateral sclerosis, N. Engl. J. Med. 327:1721-8. |
Lennon et al. 1989 Autoantibodies bind solubilized calcium channel omega-conotoxin complexes from small cell lung carcinoma: a diagnotic aid for Lambert-Eaton myasthemic syndrome. Mayo Clin Proc 64:1498-504. |
Delbono et al. Jun. 1991. IgG from amyotrophic lateral sclerosis affects tubular calcium channels of skeletal muscle. Am J Physiol 260: C1347-C1351. |
Kim et al. 1988 IgG from patients with Lambert-Eaton Syndrome blocks voltage-dependent calcium channels. Science 239: 405-8. |
Dubel et al. Jun. 1992. Molecular cloning of the .alpha.-1 subunit of an .omega.-conotoxin-sensitive calcium channel, Proc Natl. Acad. Sci 89: 5058-62. |
Appel, et al., "Amyotrophic Lateral Sclerosis: Associated Clinical Disorders and Immunologic Evaluations," 43 Arch. Neurol. 234-38 (1986). |
Younger, et al., "Motor Neuron Disease and Amyotrophic Lateral Sclerosis: Relation of High CSF Protein Content to Paraproteinemia and Clinical Syndromes," 40 Neurol. 595-99 (1990). |
Meininger, et al., "Serum Monoclonal Immunoglobulins in Amyotrophic Lateral Sclerosis: A Quantitative Analysis Using a New Western Blot Technique," 40 Neurol. 183(suppl 1) (1990). |
Oldstone, et al., "Evidence For Immune-Complex Formation in Patients With Amyotrophic Lateral Sclerosis," 2 Lancet 169-72 (1976). |
Palo, et al., "Kidney and Skin Biopsy in Amyotrophic Lateral Sclerosis," 1 Lancet 1270 (1978). |
Engelhardt, et al., "Motor Neuron Destruction in Guinea Pigs Immunized With Bovine Spinal Cord Ventral Horn Homogenate: Experimental Autoimmune Gray Matter Disease," 27 J. Neuroimmunol. 21-31 (1990). |
Horwich, et al., "Amyotrophic Lateral Sclerosis Sera Applied to Cultured Motor Neurons," 30 Arch. Neurol. 332-33 (1974). |
Touzeau, et al., "ALS Serum Has No Effect on Three Enzymatic Activities In Cultured Human Spinal Cord Neurons," 36 Neuro. 573-76 (1986). |
Hauser, et al., "Immunoblot Analysis of Circulating Antibodies Against Muscle Proteins in Amyotrophic Lateral Sclerosis and Other Neurologic Diseases," 36 Neurol. 1614-18 (1986). |
Ordonez, et al., "Antibodies Against Fetal Muscle Proteins in Serum From Patients With Amyotrophic Lateral Sclerosis," 39 Neurol. 683-86 (1989). |
Ingvar-Maeder, et al., "Search for Antibodies to Skeletal Muscle Proteins in Amyotrophic Lateral Sclerosis," 74 Arch. Neurol. Scand. 218-23 (1986). |
Endo, et al., "Antibodies to Glycosphingolipids in Patients With Multiple Sclerosis and SLE," 132 J. Immunol. 1793-97 (1984). |
Pestronk, et al., "Patterns of Serum IgM Antibodies to GM1 and GD1a Gangliosides in ALS," 25 Ann. Neurol. 98-102 (1989). |
Stefansson, et al., "Circulating Autoantibodies to the 200,000-Dalton Protein of Neurofilaments in the Serum of Healthy Individuals," 228 Sci. 1117-1119 (1985). |
Engelhardt, et al., "Experimental Autoimmune Motoneuron Disease," 26 Ann. Neurol. 368-76 (1989). |
Tajti,et al., "Cyclophosphamide Alters the Clinical and Pathological Expression of Experimental Autoimmune Gray Matter Disease," 34 J. Neuroimmunol. 143-51 (1991). |
Hamilton, et al., "Subunit Composition of the Purified Dihydropyridine Binding Protein From Skeletal Muscle," 28 Biochem. 7820-28 (1989). |
Chang, et al., "A Combined Non-Denaturing and Denaturing Gel Electrophoretic Analysis of the Subunit Composition of a Membrane Protein: The Skeletal Muscle L-Type Calcium Channel," 172 Biochem. Biophys. Res. Comm. 751-58 (1990). |
Ahlijanian, et al., "Subunit Structure and Localization of Dihydropyridine-Sensitive Calcium Channels in Mammalian Brain, Spinal Cord, and Retina," 4 Neuron 819-32 (1990). |
Hofmann, et al., "The Molecular Structure and Regulation of Muscular Calcium Channels," 31 Curr Top Cell Regul 223-239 (1990). |
Lacerda, et al., "Normalization of Current Kinetics By Interaction Between the.alpha..sub.1 and .beta. Subunits of the Skeletal Muscle Dihydropyridine-Sensitive Ca.sup.2+ Channel," 352 Nature 527-30 (1991). |
Birnbaumer, et al., "Molecular Diversity and Function of G Proteins and Calcium Channels," 44 Biol. Reproduction 207-24 (1991). |
Hui, et al., "Molecular Cloning of Multiple Subtypes of a Novel Rat Brain Isoform of the.alpha..sub.1 Subunit of the Voltage-Dependent Calcium Channel," 7 Neuron 35-44 (1991). |
Sieber, et al., "The 165-K Da Peptide of the Purified Skeletal Muscle Dihydropyridine Receptor Contains the Known Regulatory Sites of the Calcium Channel," 167 Eur. J. Biochem. 117-122 (1987). |
Snowman, et al., "Anti-w-Conotoxin GVIA Antibodies: A Valuable Tool for the Identification of the Conotoxin Receptor of Rat Brain," 17 Soc. Neurosci. Abstr. 341 (No. 142.1 1991). |
Tanabe, et al., "Primary Structure of the Receptor for Calcium Channel Blockers from Skeletal Muscle," 328 Nature 313-18 (1987). |
Perez-Reyes, et al., "Induction of Calcium Currents By the Expression of the.alpha.1-Subunit of the Dihydropyridine Receptor From Skeletal Muscle," 340 Nature 233-36 (1989). |
Appel, et al., "A Rating Scale for Amyotrophic Lateral Sclerosis: Description and Preliminary Experience," 22 Ann. Neurol. 328-33 (1987). |
Catterall, et al., "Molecular Properties of Dihydropyridine-Sensitive Calcium Channels in Skeletal Muscle," 263 J. Biol. Chem. 3535-3538 (1988). |
Engel, et al., "Motor Nerve Terminal Calcium Channels in Lambert-Eaton Myasthenic Syndrome: Morphologic Evidence for Depletion and that the Depletion is Mediated by Autoantibodies," 560 Ann NY Acad Sci 278-90 (1989). |
Imagawa, et al., "Purified Ryanodine Receptor From Skeletal Muscle Sarcoplasmic Reticulum is the Ca.sup.2+ -Permeable Pore of the Calcium Release Channel," 262 J. Biol. Chem. 16636-43 (1987). |
Lang, et al., "The Effect of Myasthenic Syndrome Antibody on Presynaptic Calcium Channels in the Mouse," 390 J. Physiol. 257-70 (1987). |
Mintz, et al., "Inhibition of N-and L-Type Ca.sup.2+ Channels by the Spider Venom Toxin .omega. AGA-IIIA,"88 Proc. Natl. Acad. Sci. USA 6628-31 (1991). |
Morton, et al., "The .alpha.1 and .alpha.2 Polypeptides of the Dihydropyridine-Sensitive Calcium Channel Differ in Developmental Expression and Tissue Distribution," 2 Neuron 1499-1506 (1989). |
Nagayama, et al., "Binding Domains of Stimulatory and Inhibitory Thyrotropin (TSG) Receptor Autoantibodies Determined With Chimeric TSG-Lutropin/Chorionic Gonadatropin Receptor," 88 J. Clin. Invest. 336-40 (1991). |
Norman, et al., "Monoclonal Antibodies Against Calcium Channels," 560 Ann. NY. Acad. Sci. 258-68 (1989). |
Sakamoto, et al., "Isolation and Biochemical Characterization of the Rabbit Brain .omega.-Conotoxin GVIA Receptor," 34 Physiologist 109 (1991). |
Vincent, et al., "Autoimmunity to the Voltage-Gated Calcium Channel Underlies the Lambert-Eaton Myasthenic Syndrome, A Paraneoplastic Disorder," 12 Trends Neurosci. 496-502 (1989). |
Westenbroek, et al., "Clustering L-Type Ca.sup.2+ Channels At the Base of Major Dendrites in Hippocampal Pyramidal Neurons," 347 Nature 281-84 (1990). |
Appel, et al., "Amyotrophic Lateral Sclerosis: Etiology and Pathogenesis," Current Neurology, 287-310 (1991). |
Appel, et al., "Immunoglobins from Animal Models of Motor Neuron Disease and From Human Amyotrophic Lateral Sclerosis Patients Passively Transfer Physiological Abnormalities to the Neuromuscular Junction," 88 Proc. Natl. Acad. Sci. USA 647-51 (1991). |
Smith, et al., "Alterations in Dihydropyridine Receptor Binding Kinetics in Amyotrophic Lateral Sclerosis (ALS) Skeletal Muscle," 17 Soc. Neurosci. 1451 (Abstract 574.14 1991). |
Engelhardt, et al., "Immune-Mediated Models of Motor Neuron Destruction in the Guinea Pig," 56 Adv. Neurol. 369-379 (1991). |
Robitaille, et al., "Strategic Location of Calcium Channels At Transmitter Release Sites of Frog Neuromuscular Synapses," 5 Neuron, 773-79 (1990). |
Troost, et al., "Lymphocytic Infiltration in the Spinal Cord of Patients With Amyotrophic Lateral Sclerosis," 8 Clin. Neuropathol. 289-294 (1989). |
Williams, et al., "Motor Neuron Disease (Amyotrophic Lateral Sclerosis)," 66 Mayo Clin. Proc. 54-82 (1991). |
Engelhardt, et al., "IgG Reactivity in the Spinal Cord and Motor Cortex in Amyotrophic Lateral Sclerosis, "47 Arch. Neurol. 1210-16 (1990). |
Appel, et al., "Immunological Models of Amyotrophic Lateral Sclerosis," New Evidence in MND/ALS Research, Chap. 27, 189-96 (1991). |
McEnery, M., et al., "Purified .omega.-Conotoxin GVIA Receptor of Rat Brain Resembles a Dihydropyridine-Sensitive L-Type Calcium Channel," 88(24) Proc. Natl. Acad. Sci. USA 11095-11099 (1991). |
Delbono, et al., Immunoglobulins G (IgG) From Patients with Amyotrophic Lateral Sclerosis (ALS) Affect Dyhidropyridine Sensitive Calcium Channels of Skeletal Muscle, 59 Biophysical J1. 65a (1991). |
Delbono, et al., "Calcium Current and Charge Movement of Mammalian Muscle: Action of Amyotrophic Lateral Sclerosis Immunoglobulins," 444 J1. Physiology 723-42 (1991). |
Appel, et al., "Autoimmunity and ALS: A Comparison of Animal Models of Immune-Mediated Motor Neuron Destruction and Human ALS," 56 Adv. in Neurology 405-12 (1991). |