METHOD FOR DRUG DISCOVERY USING FRAGMENT ASSEMBLY

Information

• Research Project
• 6345558

• ApplicationId

  6345558

• Core Project Number

  R43CA085141

• Full Project Number

  5R43CA085141-02

• Serial Number

  85141

• FOA Number

  PAR-98-073

• Sub Project Id

• Project Start Date

  7/1/1999 - 25 years ago

• Project End Date

  2/28/2001 - 23 years ago

• Program Officer Name

  LEES, ROBERT

• Budget Start Date

  9/1/2000 - 24 years ago

• Budget End Date

  2/28/2001 - 23 years ago

• Fiscal Year

  2000

• Support Year

  2

• Suffix

• Award Notice Date

  8/30/2000 - 24 years ago

Organizations

• SUNESIS PHARMACEUTICALS, INC

DESCRIPTION (Adapted from the application): The goal of this project is to validate a new method for drug-lead discovery that relies on cascaded multi-step selection of small chemical groups to construct larger molecules having high affinity for a protein target. This method increases efficiency over combinatorial chemistry in executing the selection before, rather than after, chemical synthesis. This technology will be developed using thymidylate synthase, a validated target for anti-cancer and anti-proliferative agents. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE

IC Name

• Activity

  R43

• Administering IC

  CA

• Application Type

  5

• Direct Cost Amount

• Indirect Cost Amount

• Total Cost

  109200

• Sub Project Total Cost

• ARRA Funded

• CFDA Code

  395

• Ed Inst. Type

• Funding ICs

  NCI:109200\

• Funding Mechanism

• Study Section

  ZRG1

• Study Section Name

  Special Emphasis Panel

• Organization Name

  SUNESIS PHARMACEUTICALS, INC.

• Organization Department

• Organization DUNS

• Organization City

  SOUTH SAN FRANCISCO

• Organization State

  CA

• Organization Country

  UNITED STATES

• Organization Zip Code

  94080

• Organization District

  UNITED STATES