Claims
- 1. A method for detecting rejection of an allograft in a mammal, said method comprising:
- (a) administering to said mammal an effective amount of a composition comprising at least one monospecific immunoglobulin molecule or fragment thereof diagnostically conjugated to a detectable label, said immunoglobulin or fragment directed against an MHC antigen; and
- (b) detecting rejection of said allograft, by detecting the presence of said labelled immunoglobulin or fragment.
- 2. The method of claim 1 wherein said immunoglobulin is directed against MHC Class 2 antigens.
- 3. The method of claim 1 wherein said immunoglobulin is selected from the group consisting of a monoclonal antibody and a polyclonal antibody.
- 4. The method of claim 3 wherein said monoclonal antibody is chosen from the group containing anti-HLA DR and W6/32.
- 5. The method of claim 1 wherein said detectable label is a radioactive isotope.
- 6. The method of claim 5 wherein said radioactive isotope is chosen from the group consisting of .sup.111 In, .sup.99m Tc, .sup.123 I, .sup.97 Rv, .sup.67 Cu, .sup.67 Ga, .sup.68 Ga, .sup.72 As, .sup.89 Zr and .sup.201 Tl.
- 7. The method of claim 1, wherein said allograft is a heart or kidney allograft.
- 8. The method of claim 7, wherein said allograft is a heart allograft.
- 9. The method of claim 7, wherein said allograft is a kidney allograft.
- 10. The method of claim 1 wherein said detectable label is a paramagnetic isotope.
- 11. The method of claim 10 wherein said paramagnetic isotope is chosen from the group consisting of .sup.157 Ad, .sup.55 Mn, .sup.162 Dy, .sup.52 Cr and .sup.56 Fe.
Parent Case Info
This application is a continuation-in-part application of U.S. application Ser. No. 07/592,025 filed Oct. 1, 1990, now abandoned which disclosure is herein incorporated in its entirety.
US Referenced Citations (3)
Number |
Name |
Date |
Kind |
4864020 |
Canle et al. |
Sep 1989 |
|
4925648 |
Hanssen et al. |
May 1990 |
|
5002869 |
Schlossman et al. |
Mar 1991 |
|
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
592025 |
Oct 1990 |
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