BRIEF DESCRIPTION OF THE DRAWINGS
Features and advantages of embodiments of the present disclosure will become apparent by reference to the following detailed description and drawings, in which like reference numerals correspond to similar, though not necessarily identical components. For the sake of brevity, reference numerals or features having a previously described function may not necessarily be described in connection with other drawings in which they appear.
FIG. 1 is a schematic diagram of an embodiment of forming molecular sequences (SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, and SEQ ID NO: 5 are shown as non-limiting example sequences);
FIG. 2 is a numerical simulation of the chemical confinement of photogenerated reagents;
FIG. 3 is a schematic diagram of an embodiment of forming a molecular sequence using a photogenerated acid precursor (SEQ ID NO: 6, SEQ ID NO: 7, and SEQ ID NO: 8 are shown as non-limiting example sequences);
FIG. 4 is a schematic diagram comparing a conventional solution-based acid deprotection reaction in an oligonucleotide synthesis with an embodiment of the photogenerated acid-based oligonucleotide synthesis;
FIG. 5 is a schematic diagram of an embodiment of forming molecular sequences using a photogenerated base precursor (SEQ ID NO: 9, SEQ ID NO: 10, and SEQ ID NO: 11 are shown as non-limiting example sequences);
FIG. 6 is a schematic diagram of an apparatus for synthesizing embodiments of molecular sequences;
FIG. 7A depicts oligonucleotide sequences formed on an unpatterned glass substrate;
FIG. 7B depicts oligonucleotide sequences formed on a glass microscope slide;
FIG. 7C depicts oligonucleotide sequences formed on a 200 micron silica sphere; and
FIG. 7D depicts oligonucleotide sequences formed on the inside walls of a capillary tube.
Patent Application
20070224616
