Claims
- 1. A method of treating apnea due to an underdeveloped respiratory drive center and pulmonary functions in a premature infant comprising the steps of:
- administering to a premature infant having apnea due to an underdeveloped respiratory drive center a therapeutically effective amount of a composition comprising at lest one branched-chain amino acid.
- 2. The method of claim 1 wherein the composition is administered parenterally.
- 3. The method of claim 1 wherein the composition is administered enterally.
- 4. The method of claim 1 including the step of administering enterally approximately 0.003 grams to about 0.625 grams of branched-chain amino acids per kg of body weight per hour.
- 5. The method of claim 1 including the step of administering parenterally approximately 0.01 grams to about 0.125 grams of branched-chain amino acids per kg of body weight per hour.
- 6. The method of claim 1 wherein the composition includes at least approximately 50% branched chain amino acids.
- 7. A method of treating apnea of prematurity due to an underdeveloped respiratory drive center comprising the step of administering to an infant suffering from apnea of prematurity due to an underdeveloped respiratory drive center a solution including at least one amino acid chosen from the group consisting of valine, leucine, and isoleucine.
- 8. The method of claim 7 wherein the solution is administered parenterally.
- 9. The method of claim 7 wherein the solution is administered enterally.
- 10. The method of claim 7 including the step of administering enterally approximately 0.003 grams to about 0.625 grams of branched chain amino acids per kg of body weight per hour.
- 11. The method of claim 7 including the step of administering parenterally approximately 0.01 grams to about .125 grams of branched-chain amino acids per kg of body weight per hour.
- 12. The method of claim 7 wherein the composition includes approximately 50% branched chain amino acids.
- 13. The method of claim 7 wherein the composition includes dextrose.
- 14. The method of claim 7 wherein the composition includes a lipid.
- 15. A method of treating apnea due to an underdeveloped respiratory drive center in a neonate comprising administering to the neonate a composition comprising at least approximately 50% branched-chain amino acid.
- 16. The method of claim 15 including the step of administering enterally approximately 0.003 grams to about 0.625 grams of branched-chain amino acids per kg of body weight per hour.
- 17. The method of claim 15 including the step of administering parenterally approximately 0.01 grams to about 0.125 grams of branched-chain amino acids per kg of body weight per hour.
- 18. The method of claim 15 wherein the composition includes dextrose.
- 19. The method of claim 15 wherein the composition includes a lipid.
BACKGROUND OF THE INVENTION
This is a continuation-in-part of U.S. patent application Ser. No. 443,765, filed Nov. 30, 1989, now U.S. Pat. No. 5,017,616.
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
4209531 |
Berry |
Jun 1980 |
|
5017616 |
Askanazi |
May 1991 |
|
Foreign Referenced Citations (1)
Number |
Date |
Country |
2037161 |
Jul 1980 |
GBX |
Non-Patent Literature Citations (3)
Entry |
Ghadimi et al., Total Parenteral Nutrition for Preventing and Treatment of RDS, p. 573 (1973). |
J. Takala et al., Changes in Respiratory Control Induced by Amino Acid Infusions, Critical Care Medicine, vol. 16, No. 5, (May 1988) pp. 465-469. |
The Merck Manual, 14th edition (1982) p. 1763. |
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
443765 |
Nov 1989 |
|