Claims
- 1. The method for increasing cardiac contractility in a warm-blooded mammal suffering from acutely depressed cardiac contractility which comprises administering to said mammal at a rate of between 0.5 and 10 micrograms per kilogram of body weight per minute a compound of the formula ##SPC5##
- wherein
- R and R.sub.1 are hydrogen or methyl;
- R.sub.2 and R.sub.3 are hydrogen or hydroxy, at least one of R.sub.2 and R.sub.3 being hydroxy;
- n is 1 or 2;
- subject to the limitation that when n is 2, R.sub.2 is hydrogen and R.sub.3 is hydroxy, one of R or R.sub.1 is hydrogen and the other is methyl; and the pharmaceutically acceptable acid addition salts thereof with mineral acids.
- 2. The method of claim 1 wherein the compound administered is a compound of the formula ##SPC6##
- wherein
- R and R.sub.1 are hydrogen or methyl;
- R.sub.2 and R.sub.3 are hydrogen or hydroxy, at least one of R.sub.2 and R.sub.3 being hydroxy;
- n is 1 or 2;
- subject to the limitation that when n is 2, R.sub.2 is hydrogen and R.sub.3 is hydroxy, one of R or R.sub.1 is hydrogen and the other is methyl; with the further limitations that when n is 2 and R.sub.2 and R.sub.3 are both hydroxy, then R.sub.1 is hydrogen, and when n is 1, R.sub.2 is hydrogen and R.sub.3 is hydroxy, then R and R.sub.1 are both hydrogen; and the pharmaceutically acceptable acid addition salts with mineral acids.
- 3. The method of claim 2 wherein the compound administered is 3,4-dihydroxy-N-[3-(4-hydroxyphenyl)-1-methyl-n-propyl]-.beta.-phenethylamine hydrochloride.
- 4. The method of claim 2 wherein the compound administered is levo-3,4-dihydroxy-N-[3-(4-hydroxyphenyl)-1-methyl-n-propyl]-.beta.-phenethylamine hydrochloride.
- 5. The method of claim 2 wherein the compound administered is 3,4-dihydroxy-N-[3-(3-hydroxyphenyl-n-propyl]-.beta.-phenethylamine hydrochloride.
- 6. The method of claim 2 wherein the compound administered is 3,4-dihydroxy-N-[3-(4-hydroxyphenyl)-n-propyl]-.alpha.-methyl-.beta.-phenethylamine hydrochloride.
- 7. The method of claim 2 wherein the compound administered is 3,4-dihydroxy-N-[2-(3,4-dihydroxyphenyl)ethyl]-.beta.-phenethylamine.
- 8. The method of claim 2 wherein the compound administered is 3,4-dihydroxy-N-[3-(3,4-dihydroxyphenyl)-n-propyl]-.beta.-phenethylamine hydrochloride.
Parent Case Info
This is a division of application Ser. No. 243,466, filed Apr. 12, 1972 now abandoned.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
2276619 |
Kulz |
Mar 1942 |
|
Divisions (1)
|
Number |
Date |
Country |
Parent |
243466 |
Apr 1972 |
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