Claims
- 1. A method for inhibiting interleukin -2 (IL-2) production by administering to a subject in need thereof an amount of a compound of formula (I) effective to inhibit the production of IL-2: whereinR1 is hydroxy or pharmaceutically acceptable protected hydroxy selected from the group consisting of 1-(lower alkylthio)(lower)alkyloxy, tri(lower)alkylsilyloxy, lower alkyl-diphenyl-silyloxy, pharmaceutically acceptable organic carboxylic acyloxy, pharmaceutically acceptable organic sulfonic acyloxy, and pharmaceutically acceptable organic carbamic acyloxy, R2 is hydrogen or the same meanings as R1, R3 is methyl, ethyl, propyl or allyl, n is an integer of 1 or 2, and the symbol of a line and dotted line is a single bond or a double bond, or pharmaceutically acceptable basic salt thereof.
- 2. The method of claim 1, in which the compound (I) is 17-allyl-1,14-dihydroxy-12-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.04,9]octacos-18-ene-2,3,10,16-tetraone.
- 3. The method of claim 1, in which the compound (I) is 17-ethyl-1,14-dihydroxy-12-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.04,9]octacos-18-ene-2,3,10,16-tetraone.
Priority Claims (3)
Number |
Date |
Country |
Kind |
8430455 |
Dec 1984 |
GB |
|
8502869 |
Feb 1985 |
GB |
|
8508420 |
Apr 1985 |
GB |
|
Parent Case Info
This application is a Continuation of application Ser. No. 09/411,630, filed on Oct. 1, 1999, now U.S. Pat. No. 6,201,005, which is a Continuation Of application Ser. No. 09/084,099 filed on May 26, 1998, U.S. Pat. No. 6,028,097, which is a Continuation of Ser. No. 08/753,950, filed Dec. 3, 1996, now U.S. Pat. No. 5,830,717, which is a Continuation of Ser. No. 08/450,412, filed May 25, 1995, now U.S. Pat. No. 5,624,842, which is a Divisional of Ser. No. 07/824,384, filed Jan. 23, 1992, abandoned, which is a Divisional of Ser. No. 07/491,205, filed Mar. 9, 1990, now U.S. Pat. No. 5,110,811, which is a Continuation of 06/868,749, filed May 30, 1986, now U.S. Pat. No. 4,929,611, which is a Continuation-in-Part of 06/799,855, filed Nov. 20, 1985, now U.S. Pat. No. 4,894,366.
US Referenced Citations (14)
Foreign Referenced Citations (1)
Number |
Date |
Country |
0 315 978 |
May 1989 |
EP |
Non-Patent Literature Citations (4)
Entry |
Bushman, et al., “Bergey's Manual of Dertminative Bacteriology,” (1974), p. 806. |
Valdimarsson, et al., “Psoriasis: a disease of abnormal keratinocyte proliferation induced by T lymphocytes,” inumology Today, vol. 7, No. 9, (1986). |
Findlay, J. et al., “On the Chemistry and High Field Nuclear Magnetic Resonance Spectroscopy of Rapimycin,” Canadian Journ. Of Chem, vol. 58, (1980) pp. 579-590. |
Baker, et al., British Journ. Of Dermatology, vol. 100, pp. 555-564 (1984). |
Continuations (5)
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Number |
Date |
Country |
Parent |
09/411630 |
Oct 1999 |
US |
Child |
09/721650 |
|
US |
Parent |
09/084099 |
May 1998 |
US |
Child |
09/411630 |
|
US |
Parent |
08/753950 |
Dec 1996 |
US |
Child |
09/084099 |
|
US |
Parent |
08/450412 |
May 1995 |
US |
Child |
08/753950 |
|
US |
Parent |
06/868749 |
May 1986 |
US |
Child |
07/491205 |
|
US |
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
06/799855 |
Nov 1985 |
US |
Child |
06/868749 |
|
US |