Method for judging feature of malignant tumor

Abstract

A method for judging feature of malignant tumor is described. The method comprises obtaining step, first comparing step, second comparing step and judging step. The obtaining step comprises obtaining a first parameter based on activity and expression level of a first cyclin dependent kinase (first CDK) contained in a tumor cell of the malignant tumor, a second parameter based on activity and expression level of a second cyclin dependent kinase (second CDK) contained in the tumor cell, a third parameter based on the first parameter and the second parameter, and a fourth parameter based on expression level of a cyclin contained in the tumor cell. The first comparing step comprises comparing a first threshold value with the third parameter. The second comparing comprises comparing a second threshold value with the fourth parameter. The judging step comprises judging the feature of the malignant tumor based on the comparison results of the first comparing step and the second comparing step.

Description

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 is a block diagram showing the structure of the computer system 100.

FIG. 2 is a flow chart illustrating a processing sequence of a computer program for executing the method 3 according to a preferred embodiment of the present invention.

Claims

1. A method for judging feature of malignant tumor, comprising the steps of: obtaining a first parameter based on activity and expression level of a first cyclin dependent kinase (first CDK) contained in a tumor cell of the malignant tumor, a second parameter based on activity and expression level of a second cyclin dependent kinase (second CDK) contained in the tumor cell, a third parameter based on the first parameter and the second parameter, and a fourth parameter based on expression level of a cyclin contained in the tumor cell;first comparing a first threshold value with the third parameter;second comparing a second threshold value with the fourth parameter;judging the feature of the malignant tumor based on the comparison results of the first comparing step and the second comparing step.

2. The method according to claim 1, wherein the first parameter is specific activity of the first CDK.

3. The method according to claim 1, wherein the second parameter is specific activity of the second CDK.

4. The method according to claim 1, wherein the third parameter is ratio of the first parameter versus the second parameter.

5. The method according to claim 1, wherein the first CDK and the second CDK are selected from the group consisting of CDK1, CDK2, CDK4 and CDK6.

6. The method according to claim 1, wherein the cyclin is capable of forming a complex with the first CDK or the second CDK.

7. The method according to claim 1, wherein the cyclin is capable of forming a complex with at least one CDK selected from the group consisting of CDK1, CDK2, CDK4 and CDK6.

8. The method according to claim 7, wherein the cyclin are selected from the group consisting of cyclin A, cyclin B, cyclin D and cyclin E.

9. The method according to claim 5, wherein the first CDK is CDK1 and the second CDK is CDK2.

10. The method according to claim 8, wherein the cyclin is cyclin B or cyclin E.

11. The method according to claim 1, wherein the malignant tumor is carcinoma.

12. The method according to claim 1, wherein the malignant tumor is breast cancer.

13. The method according to claim 1, wherein the feature of the malignant tumor is a risk of recurrence.

14. The method according to claim 13, wherein the judging step is performed so as to judge the risk of recurrence as high risk, intermediate risk or low risk, based on a first comparison result of the first threshold value with the third parameter, and a second comparison result of the second threshold value with the fourth parameter.

15. The method according to claim 14, wherein the low risk is determined when the third parameter is less than the first threshold value,the intermediate risk is determined when the third parameter is not less than the first threshold value and the fourth parameter is less than the second threshold value, andthe high risk is determined when the third parameter is not less than the first threshold value and the fourth parameter is not less than the second threshold value.

16. The method according to claim 14, wherein the low risk is determined when the third parameter is less than the first threshold value and the fourth parameter is less than the second threshold value,the intermediate risk is determined when the third parameter is not less than the first threshold value and the fourth parameter is less than the second threshold value and when the third parameter is less than the first threshold value and the fourth parameter is not less than the second threshold value, andthe high risk is determined when the third parameter is not less than the first threshold value and the fourth parameter is not less than the second threshold value.

17. The method according to claim 1, wherein the malignant tumor belongs to Stage I or Stage IIA in stage classification.

18. A method for judging risk of recurrence of malignant tumor, comprising steps of: obtaining a first parameter based on activity and expression level of a first cyclin dependent kinase (first CDK) contained in a tumor cell of the malignant tumor, a second parameter based on activity and expression level of a second cyclin dependent kinase (second CDK) contained in the tumor cell, a third parameter based on the first parameter and the second parameter, and a fourth parameter based on expression level of a cyclin contained in the tumor cell;first comparing a first threshold value with the third parameter;first classifying the malignant tumor into one of Group A and Group X having a risk of recurrence higher than that of the Group A based on a comparison result of the first comparing step;second comparing a second threshold value with the fourth parameter when it is judged that the malignant tumor is included in the Group X; andsecond classifying the Group X into Group B and Group C having the risk of recurrence higher than that of the Group B based on a comparison result of the second comparing step.

19. A computer program product for enabling a computer to execute a method of a method for judging feature of malignant tumor, the computer program product comprising: a computer readable medium; andsoftware instructions, on the computer readable medium, for enabling the computer to perform predetermined operations comprising: obtaining a first parameter based on activity and expression level of a first cyclin dependent kinase (first CDK) contained in a tumor cell of the malignant tumor, a second parameter based on activity and expression level of a second cyclin dependent kinase (second CDK) contained in the tumor cell, a third parameter based on the first parameter and the second parameter, and a fourth parameter based on expression level of a cyclin contained in the tumor cell;first comparing a first threshold value with the third parameter;second comparing a second threshold value with the fourth parameter;judging the feature of the malignant tumor based on the comparison results of the first comparing step and the second comparing step.

20. The computer program product according claim 19, wherein the judging step is performed so as to judge the risk of recurrence as high risk, intermediate risk or low risk, based on a first comparison result of the first threshold value with the third parameter, and a second comparison result of the second threshold value with the fourth parameter.