Claims
- 1. A method for treating hyperglycemia in a patient, wherein the method comprises administering to the patient a dosage form comprising 2 mg to 750 mg glipizide that is administered at a therapeutically effective dose of 10 ng to 25 mg over 24 hours from the dosage form comprising 1 mg to 300 osmagent and a hydrogel selected from the group consisting of poly(ethylene oxide) having a 4,000,000 to 8,000,000 molecular weight and a carboxymethylcellulose having a 200,000 to 1,000,000 molecular weight to the patient to produce the intended effect in the patient.
- 2. A method for treating hyperglycemia in a patient, wherein the method comprises administering to the patient a dosage form comprising a composition that comprises 2.0 mg to 750 mg of a glipizide that is administered at a dose of 10 ng to 25 mg per hour over an extended period of 24 hours, from the composition that comprises 100 mg to 320 mg of a poly(ethylene oxide) having a 80,000 to 350,000 molecular weight and 5 mg to 50 mg of a hydroxypropylmethylcellulose having a 9,200 to 22,000 molecular weight to produce the intended therapy.
- 3. A method for lowering blood sugar in the treatment of a diabetic patient, which method comprises orally administering to the patient an effective blood sugar lowering dose of a composition comprising glipizide and a pharmaceutically acceptable carrier, which carrier comprises 100 mg to 250 mg of a hydroxypropylmethylcellulose of 40,000 to 80,000 molecular weight and 40 mg to 70 mg of polyvinylpyrrolidone of 30,000 to 70,000 molecular weight, which blood sugar lowering composition is administered over time to produce the intended lowering of the blood sugar in the patient.
CROSS-REFERENCE TO CO-PENDING APPLICATION
This application is a division of application Ser. No. 08/180,409, filed Jan. 11, 1994, and benefit of the filing date of said earlier filed application is claimed under 35 U.S.C. which is a continuation-in-part of U.S. application Ser. No. 07/650,822 filed Jan. 22, 1991, U.S. Pat. No. 5,545,413 which Ser. No. 07/650,822 is a division of U.S. application Ser. No. 07/402,314, filed Sept. 5, 1989 which Ser. No. 07/402,314 now is U.S. Pat. No. 5,024,843 issued Jun. 18, 1991, and was copending with U.S. Ser. No. 07/652,717 now U.S. Pat. No. 5,091,190 issued Feb. 25, 1992, and benefit of these filing dates is claimed herein.
US Referenced Citations (20)
Non-Patent Literature Citations (5)
Entry |
Martindale, The Extra Pharmacopoeia, 29th Ed. (1989) p. 390. |
AHFS Drug Information, (1989) pp. 1741-1745. |
J. Am. Phar. Assoc., Sci. Ed., vol. 48 (1959) pp. 451-459. |
J. Am. Phar. Assoc., Sci. Ed., vol. 49 (1960) pp. 82-84. |
Remington's Pharmaceutical Sciences, 14th Ed., (1970) pp. 1626-1678. |
Divisions (2)
|
Number |
Date |
Country |
Parent |
180409 |
Jan 1994 |
|
Parent |
402314 |
Sep 1989 |
|
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
650822 |
Jan 1991 |
|