Claims
- 1. A method for preparing a physically stable and homogenous powdered pharmaceutical preparation to be inhaled comprising particles of a pharmaceutical and at least one physiologically acceptable additive, said method comprising:suspending particles of said preparation in a suspending agent, thereby forming a suspension, wherein the particles are essentially insoluble in the suspending agent, and; evaporating the suspending agent from the suspension, wherein said particles comprise the particles preparation and the carrier in admixture.
- 2. A method according to claim 1, wherein the suspending agent is selected from the group consisting of: alkanes, alcohols, ketones and mixtures thereof.
- 3. A method according to claim 2, wherein the suspending agent is selected from the group consisting of: an alkane, preferably n-hexane or heptane, an alcohol, and a halogenated hydrocarbon.
- 4. A method according to claim 1 wherein the suspended particles are deagglomerated and/or homogenized by stirring.
- 5. A method according to claim 1, further comprising ultrasonic treatment of the suspension.
- 6. A method according to claim 1, wherein the suspension is stored for a time sufficient to allow contact between the particles and the suspending agent before evaporation.
- 7. A method according to claim 1, wherein the suspension is stored for a time between about 3 minutes and 5 days.
- 8. A method according to claim 1, wherein said suspending is at a temperature of greater than about room temperature.
- 9. A method according to claim 8, wherein said temperature is between about 40° C. and about 90° C.
- 10. A method according to claim 1, wherein the active agent is an organic compound containing an amorphous substance.
- 11. A method according to claim 10, wherein the active agent is salbutamol.
- 12. A method according to claim 1, wherein the active agent is a steroid.
- 13. A method according to claim 1, wherein the active agent is budesonide.
- 14. The product obtained by the method according to claim 1.
- 15. The method according to claim 3, wherein the alkane is selected from the group consisting of n-hexane and n-heptane.
- 16. The method of claim 3, wherein said alcohol is methanol or ethanol.
- 17. The method according to claim 7, wherein the suspension is stored for about 3 hours.
- 18. The method according to claim 9, wherein said temperature is between about 40° C. and about 70° C.
- 19. The method according to claim 9, wherein said temperature is between about and 50° C. and about 70° C.
Priority Claims (1)
Number |
Date |
Country |
Kind |
974664 |
Dec 1997 |
FI |
|
Parent Case Info
This application is the U.S. National Phase under 35 U.S.C. §371 of International Application PCT/F198/01001, filed Dec. 21, 1998, which claims priority of Finnish Patent Application No. 974664, filed Dec. 21, 1997.
PCT Information
Filing Document |
Filing Date |
Country |
Kind |
PCT/FI98/01001 |
|
WO |
00 |
Publishing Document |
Publishing Date |
Country |
Kind |
WO99/34778 |
7/15/1999 |
WO |
A |
US Referenced Citations (5)
Foreign Referenced Citations (3)
Number |
Date |
Country |
937303 |
Sep 1963 |
GB |
WO 9218110 |
Oct 1992 |
WO |
WO 9505805 |
Mar 1995 |
WO |
Non-Patent Literature Citations (1)
Entry |
Remington's Pharmaceutical Sciences, 16th ed, 1980, p. 203. |