Method for Modulating Hair Growth

Abstract

The present invention relates to the use of Lhx2 as a target for modulating the hair growth. Screening assays for identifying agents which increase or decrease the expression or activity of Lhx2 are provided.

Description

BACKGROUND OF THE INVENTION

Hair follicle morphogenesis involves a temporal series of reciprocal interactions between the ectoderm and its underlying mesenchyme (Hardy (1992) Trends Genet. 8:55; Millar (2002) J. Invest. Dermatol. 118:216; Schmidt-Ullrich and Paus (2005) Bioessays 27:247). During embryogenesis, the skin epidermis develops from a single uniform layer of multipotent cells, separated from the mesenchymally-derived dermis by a basement membrane of extracellular matrix. Cells of this proliferative basal layer can be committed into one of two major lineages. To serve its function as a protective barrier, cells directed towards the epidermal lineage begin a program of terminal differentiation by detaching from the basement membrane, moving outward toward the skin surface, and undergoing metabolic changes to create a keratinized, stratified squamous cell layer. Alternatively, cells of the basal layer can give rise to hair follicles. In response to inductive signals, embryonic hair morphogenesis begins with a localized thickening of epidermal cells and a subsequent bud-like down-growth into the dermis. Known as a hair placode or hair germ, these cells send a reciprocal signal back to the underlying mesenchymal cells to organize into a dermal condensate, the precursor of the dermal papilla. As the hair follicle continues to develop by growing further down into the dermis, a group of rapidly proliferating follicular cells called the matrix surrounds the dermal papilla, forming the hair bulb. Cells losing contact with the hair bulb become the outer root sheath, contiguous with the interfollicular epidermis. The close association between the matrix and dermal papilla within the hair bulb likely results in another set of epithelial-mesenchymal exchange of signals to begin terminal hair differentiation. Specific hair lineages are adopted by the matrix cells as they move upward in concentric rings of cells to form the different layers of the hair follicle, including the inner root sheath and hair shaft. At some point during this morphogenetic process, stem cells residing in the bulge are specified and set aside for the postnatal hair cycle and epidermal repair.

Some of the molecular events involved in hair follicle morphogenesis have been elucidated. In response to an inductive Wnt and an inhibitory Bmp signal (Noggin), small hair placodes bud from the epithelium, giving rise to larger hair germs (DasGupta and Fuchs (1999) Development 126:4557; Huelsken, et al. (2001) Cell 105:533; Botchkarev, et al. (1999) Nature Cell Biol. 1:158; Jamora, et al. (2003) Nature 422:317). In the presence of the mitogen Shh, these hair germs develop further and grow downwards to form a mature follicle that actively produces hair (Chiang, et al. (1999) Dev. Biol. 205:1; Oro and Higgins (2003) Dev. Biol. 255:238; St-Jacques, et al. (1998) Curr. Biol. 8:1058). Although the molecular details of bud formation are still being defined, the general features of this process are repeated at the start of each postnatal hair cycle when multipotent stem cells in the hair follicle bulge become activated to initiate a new round of hair growth. In addition, the early epithelial remodeling to form the hair germ shares many features with the development of other epithelial tissues and organs, including feathers, teeth, and mammary glands (Hogan (1999) Cell 96:225; Pispa and Thesleff (2003) Dev. Biol. 262:195; Yue, et al. (2005) Nature 438:1026). Understanding how tissues form buds which then progress along different lineages is predicated on elucidating the molecular mechanisms that funnel these early signaling pathways into a transcriptional program that drives morphogenesis.

SUMMARY OF THE INVENTION

The present invention is a method for modulating hair growth by regulating the expression or activity of Lhx2. The present invention also relates to the use of Lhx2 in a screening assay to identify an agent which modulates hair growth. The screening assay involves contacting a test cell expressing a reporter operably linked to an Lhx2 promoter with an agent and detecting expression of the reporter in the test cell, wherein a decrease in reporter expression is indicative of an agent which stimulates hair growth and an increase in reporter expression is indicative of an agent which inhibits hair growth.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 shows that Lhx2 maintains follicle stem cells in a quiescent, inactive state. FIG. 1A shows CD34 quantification by flow cytometry in telogen and anagen follicles during the first postnatal cycle. FIG. 1B shows loss of BrdU label retention in KO follicles. Following a 3-day BrdU pulse on d26-28 at the onset of anagen in both wild-type and KO skin grafts, and a 4-week chase when follicles had entered telogen, label retaining cells (LRCs) concentrated in the infrequently dividing bulge stem cells of wild-type follicles, but LRCs were diminished in Lhx2 KO skin. FIG. 1C shows increased BrdU incorporation by KO follicle stem cells. Following a 4-hour BrdU pulse at d40, when wild-type and KO follicles were in mid-anagen of their first postnatal hair cycle, cells were isolated and α6-integrin expressing S-phase cells were quantified by flow cytometry.

FIG. 2 shows the normal program of hair development.

DETAILED DESCRIPTION OF THE INVENTION

It has now been found that Lhx2 is a transcription factor positioned downstream of signals necessary to specify hair follicle stem cells, but upstream from signals required to drive activated stem cells to terminally differentiate. Using gain and loss of function studies, Lhx2 was found to maintain the growth and undifferentiated properties of hair follicle progenitors. Accordingly, the present invention relates to the use of Lhx2 as a target for modulating hair growth. For example, by increasing the expression or activity of Lhx2, hair follicles can be maintained in a resting or quiescent state thereby preventing or reducing unwanted hair growth, whereas decreasing the expression or activity of Lhx2 can be employed in the stimulation or activation of follicle stem cell proliferation and therefore stimulation of hair growth. Thus, the present invention also embraces screening assays for identifying agents which modulate the expression or activity of Lhx2. Such agents can be identified in in vitro or in vivo screening assays which monitor the activity or expression of Lhx2 (e.g., via reporter protein expression). Agents which can be screened in accordance with the instant assays include the Lhx2 protein or fragments thereof, as well as agonistic or antagonistic anti-Lhx2 antibodies. Ribozymes, siRNA, antisense oligonucleotides and the like can be screened for inhibiting the expression of Lhx2 and small organic molecules can be identified which inhibit or stimulate the expression or activity of Lhx2.

Embryonic hair progenitors were isolated using mice doubly transgenic for a Keratin 14-GFP gene expressed in skin keratinocytes and the Wnt reporter gene TOPGAL, transcribed in hair placodes and germs where β-catenin/Lef1 complexes are active (DasGupta and Fuchs (1999) supra; Vaezi, et al. (2002) Dev. Cell 3:367). In these early hair progenitors, E-cadherin is down-regulated and P-cadherin is upregulated (Jamora, et al. (2003) supra). By embryonic day 17 (E17), dispase was used to separate the epidermis, including hair placodes and germs, from the underlying dermis, which harbored more mature hair pegs and follicles. Using fluorescence-activated cell sorting (FACS) on the epidermal fraction, the early “PCAD+” hair progenitors (K14-GFP+, α6-integrin+, P-cadherin+) were then separated from the “PCAD−” interfollicular epidermis (K14-GFP+, α6-integrin+, P-cadherin−) based on their differential surface P-cadherin expression. Characterization of these two cell populations confirmed their similarities in K5 and β4-integrin expression, but their distinct activities of TOPGAL and expression of known hair placode markers.

The gene expression profiles of purified PCAD+ hair progenitors and PCAD− interfollicular basal keratinocytes were further analyzed using oligonucleotide microarrays. Utilizing fold differences of known hair placode markers as a sensitivity gauge, a 2-fold cut-off was assigned as a genuine difference between the two populations. A total of 1394 probes (660 in PCAD+; 734 in PCAD−) were preferentially expressed greater than 2-fold in one population over the other (Table 1). The Mean Log2 Ratio of Table 1 was calculated for PCAD+ with respect to PCAD− signal values.

A short list of differentially expressed genes relevant to the present study is provided in Table 2. Genes designated with “#” were upregulated and genes designated with “*” were downregulated within the bulge stem cells of postnatal hair follicles compared against the total skin epithelial cell population (Blanpain, et al. (2004) Cell 118:6). A number of these genes have documented roles in either hair morphogenesis (PCAD+) or epidermal differentiation (PCAD−). The interfollicular epidermal population was typified by adhesive and cytoskeletal components, Notch signaling factors, C-myc, Kruppel-like factors, as well as Bmp-responsive transcription factors (Grainyhead-like, Ovol) previously implicated in epidermal differentiation (Fuchs and Raghavan (2002) Nature Rev. Genet. 3:199; Tao, et al. (2005) Development 132:1021; Ting, et al. (2005) Science 308:411; Arnold and Watt (2001) Curr. Biol. 11:558). In contrast, the hair germ signature featured Wnts, Shh, Bmps, Tgfβs, and tyrosine kinase receptor signaling morphogens, as well as a number of different transcription factors. Although some of these transcription factors have not been previously implicated in the specification of skin progenitor fates, others have previously been associated with postnatal genetic hair disorders, including Cutl1, Gli1, Hoxc13, Sox9, Trps1, and Vdr (Millar (2002) supra; Schmidt-Ullrich, et al. (2005) supra).

Unexpectedly, several of the uncharacterized transcription factors on this list were also found to be differentially expressed in the postnatal hair follicle bulge (Blanpain, et al. (2004) supra; Morris, et al. (2004) Nature Biotechnol. 22:411) (Table 2), indicating that the embryonic hair germ may exhibit functional properties similar to adult stem cells. Although the hair germ is committed to a follicular cell fate, it remains undifferentiated like bulge stem cells, yet capable of differentiating into all the lineages of the hair follicle, including the sebaceous gland (Ito, et al. (2005) Nature Med. 11:1351; Levy, et al. Dev. Cell 9:855).

To determine whether the early hair germs may reflect hair follicle stem cells and regulate key steps in progenitor cell differentiation, focus was placed on the transcription factors emanating from the screen that were known to govern developmental cell fate specification in other tissues and organs. Lim-homeodomain transcription factor Lhx2 was of interest since Lhx2 null mutant animals display defects in patterning and cell fate determination during brain development (Porter, et al. (1997) Development 124:2935; Bulchand, et al. (2001) Mech. Dev. 100:165; Hirota and Mombaerts (2004) Proc. Natl. Acad. Sci. USA 101:8751). In addition, they lack definitive erythropoeisis and conversely, hematopoetic progenitor cells can be maintained in vitro by forced expression of Lhx2 (Pinto do, et al. (2002) Blood 99:3939). Lhx2 null animals die between E15.5-E16.5, and a possible role for Lhx2 in skin has not been examined.

Lhx2 was upregulated 18-fold in the PCAD+ population relative to PCAD− population by microarray. Semi-quantitative RT-PCR and in situ hybridization confirmed this marked differential expression. By immunofluorescence, Lhx2 first appeared in early hair placodes, and as morphogenesis progressed, became prominent at the leading front of invaginating hair germs and pegs. As down-growth neared completion and hair differentiation began, Lhx2 concentrated in the upper outer root sheath (ORS) at a presumptive site (bulge) of the developing postnatal follicle stem cell compartment. Concomitantly, expression diminished at the base of the follicle, where highly proliferative matrix cells give rise to the differentiating inner root sheath and hair shaft. In adult follicles, Lhx2 concentrated in the bulge, and as the new hair cycle initiated, Lhx2 extended to the emerging secondary hair germs. Based upon these patterns, Lhx2 appeared to function in specifying the embryonic hair follicle progenitor cells that then persist as bulge stem cells in adult follicles.

To more precisely define Lhx2's role in hair follicle stem cell specification and/or maintenance, its status was examined in various genetic mutant embryos defective in different aspects of hair morphogenesis. In the complete absence of hair follicle induction or bulge maintenance, as reflected in β-catenin conditionally null (cKO) skin, Lhx2 was not expressed. In Shh knockout embryos, where hair germs are specified but unable to progress, Lhx2 expression was dramatically reduced. This positioned Lhx2 downstream of Wnt and Shh, where it could play a role in establishing or expanding the early progenitors necessary for hair follicle morphogenesis.

Bmp signaling is not required for hair follicle induction, even though Bmp ligands and receptors are expressed in embryonic hair germs and in postnatal follicle stem cells. Correspondingly, in BmpR1a cKO skin, Lhx2 was expressed in both embryonic hair germs and the presumptive bulge of developing follicles. Conversely, Bmp signaling is required for differentiation, and in the absence of BmpR1a, proliferating undifferentiated hair progenitor cells accumulate at the follicle base (Andl, et al. (2004) Development 131:2257; Kobielak, et al. (2003) J. Cell Biol. 163:609). Lhx2 was noticeably enhanced in these follicles, with strong staining throughout the ORS and matrix. These cells were also positive for Shh and Lef1. Thus, in the absence of terminal hair differentiation, cells accumulating in postnatal BmpR1a null follicles resembled early embryonic hair follicle progenitors.

If Lhx2 governs the gene expression program of undifferentiated follicle stem cells or their early progenitors, then misexpression of Lhx2 in interfollicular epidermis might result in an induction of hair follicle progenitor genes. Accordingly, K14-Lhx2 transgenic mice were generated to examine this possibility. Although more hair follicles were not induced, Lhx2 markedly suppressed morphological and biochemical signs of epidermal differentiation and failed to produce a functional lipid barrier. Most notable was the induction of Tcf3 and Sox9, two key transcription factors of adult hair follicle stem cells (Merrill, et al. (2001) Genes Dev. 15:1688; Vidal, et al. (2005) Curr. Biol. 15:1340). Lhx2 also suppressed differentiation in tongue epithelium. These findings indicate that Lhx2 can maintain cells in an undifferentiated state, further enforcing the link between Lhx2 and stemness.

If Lhx2 is required for follicle stem cell maintenance, then its absence could alter the ability of hair follicles to form. In support of this notion, E16 Lhx2 null embryos displayed an −40% reduction in overall density of P-cadherin positive hair follicles, with no noticeable defect in the epidermis or embryo size. Marked reduction in follicle density is a feature of other mouse mutants in key hair follicle morphogenetic genes. Although Lhx2 KO follicle density was reduced, Shh, Wnt10b, Bmp2, Bmp4 and Lef1 expression appeared unaffected in those hair placodes and germs that developed. In Lhx2 null skin engraftments, follicles appeared morphologically and biochemically indistinguishable from their wild-type counterparts. Taken together, the gain and loss of function studies indicate that Lhx2, reflecting its expression pattern, functions to specify and maintain hair follicle stem cells, but does not function in their differentiation.

If Lhx2 maintains the undifferentiated state of embryonic and adult follicle stem cells, then Lhx2 null follicles might exhibit alterations in the transition of stem cells from the resting (telogen) to the growing (anagen) phase of the postnatal hair cycle. Using skin grafts, the hair cycles of wild-type and Lhx2 KO follicles were compared. The initial morphogenetic and first postnatal Lhx2 KO hair cycles progressed similarly to wild-type and by 8 weeks, KO follicles had returned to telogen. By contrast, at 11 weeks when most wild-type follicles were still in this extended telogen, KO follicles had precociously entered the next hair cycle. Moreover, upon shaving at 8 weeks, most wild-type hairs remained in telogen while KO hairs consistently and uniformly grew back within 3 weeks, confirming their shortened resting phase.

Immunofluorescence and FACS analyses revealed that KO follicles exhibited diminished CD34, a surface marker of bulge stem cells (FIG. 1A) (Blanpain, et al. (2004) supra). This reduction in CD34 was observed irrespective of hair cycle number or stage. Other stem cell markers examined (i.e., Tenascin C and S100A6) were comparably expressed in wild-type and KO bulges.

Although CD34 marks adult stem cells, it is not found in embryonic skin progenitors, suggesting that its reduction could be an indication of enhanced proliferative activity within KO follicle stem cells. This was supported by bromodeoxyuridine (BrdU) pulse-chase experiments conducted prior to marked deviations in hair cycling (FIG. 1B). Only the wild-type follicle bulge compartment retained appreciable BrdU label administered at the onset of anagen and chased for 4 weeks (Blanpain, et al. (2004) supra; Taylor, et al. (2000) Cell 102:451). By contrast, KO hair follicles displayed very few label retaining cells (LRCs), confirmed and quantified by flow cytometry.

The reduction in label retention was accompanied by enhanced proliferation within the KO bulge. After a 4-hour BrdU pulse during full anagen, the percentage of S-phase labeled bulge cells was 2× higher than normal (FIG. 1C). By contrast, the number of S-phase cells in the interfollicular/ORS of wild-type and KO skins was comparable, underscoring the specificity of this hyperproliferation. The elevated proliferative activity of the KO bulge did not appear to alter the overall size of the stem cell niche. It was concluded that without Lhx2, follicle stem cells are more readily activated to proliferate and differentiate along the hair lineage. On the other hand, Lhx2 is not sufficient to induce quiescence as transgenic expression did not suppress proliferation or induce CD34 in the skin epithelium.

By isolating and transcriptionally profiling embryonic hair placodes and interfollicular epidermis, genes implicated in hair development have been identified (Table 1) and novel differences have been uncovered that could be important in orchestrating lineage specification of multipotent skin progenitors. By way of illustration, Lhx2 studies revealed that it functions as a molecular brake in regulating the switch between hair follicle stem cell maintenance and activation. Although follicles can be specified embryonically without Lhx2, their overall numbers are reduced, and Lhx2 null follicles that do form are not proficient in maintaining the resting state and precociously activate. Once committed, cells no longer require or express Lhx2 and progress along a normal program of terminal differentiation.

Finally, Lhx2 is the first identified marker expressed specifically by both embryonic hair placodes and postnatal follicle stem cells of the bulge. Lhx2 now provides a segue to dissect the transcriptional mechanisms that underlie stem cell maintenance within the hair follicle and also serves as a target for modulating hair growth. Further, one or more of the genes identified as being involved in embryonic hair placodes and interfollicular epidermis (Table 1) can be used as a signature of the early hair germ that makes a follicle. Moreover, as with Lhx2, it is contemplated that one of more of the genes listed in Table 1 can be used as targets for modulating hair growth.

The invention is described in greater detail by the following non-limiting examples.

EXAMPLE 1

Mice

Lhx2^−/−; Shh^−/−; BmpR1a^fl/fl; Pcad^−/−; β-catenin^fl/fl are known in the art and were produced according to convention methods. TOPGAL and K14-GFPactin transgenic mice are also known in the art (DasGupta and Fuchs (1999) supra; Vaezi, et al. (2002) Dev. Cell 3:367). Lhx2 transgenic mice were generated by cloning full-length murine Lhx2 cDNA (GENBANK Accession No. NM_010710) into a vector driving expression from the human keratin 14 promoter faithfully expressed in the interfollicular epidermis and outer root sheath of hair follicles (Vasioukhin, et al. (1999) Proc. Natl. Acad. Sci. USA 96:8551).

EXAMPLE 2

Engraftment and BrdU Experiments

Full thickness skins were removed from the torsos of sex-matched wild type and Lhx2 null E15.5 embryos, and placed onto the backs of anesthetized female nu/nu (Nude) recipient mice, with each recipient receiving a WT and KO graft. Grafts were secured by sterile gauze and cloth bandages, which were removed after healing (12-13 days). Hairs typically appeared within 1 week after grafting. A total of forty grafts were placed (20 wild-type and 20 KO), and each showed a consistent phenotype dependent on the presence or absence of Lhx2 in the donor skin. 5′-Bromo-2′-deoxyuridine (BrdU; Sigma-Aldrich, St. Louis, Mo.) pulse-chase experiments were performed as described. Intra-peritoneal injections (50 μg/g BrdU) were carried out twice a day for 3 days at day 26 to 28 post-graft and analyzed 4 weeks later for label retention. For cell cycle analysis, mice were injected once with 50 μg/g BrdU at day 40 postgraft and analyzed 4 hours later for BrdU incorporation. A minimum of 4 grafts (two wild-type and two Lhx2 KO) were used for each BrdU experiment. Since K14-Lhx2 transgenic mice died perinatally, newborn back skins were similarly grafted.

EXAMPLE 3

Histology, Immunofluorescence, and in situ Hybridizations

Tissues were embedded in OCT and frozen sections were fixed in 4% paraformaldehyde and subjected to immunofluorescence microscopy or hematoxylin/eosin staining. When applicable, the MOM basic kit (Vector laboratories) was used to prevent non-specific binding of mouse monoclonal antibodies (Abs). Antibodies and dilutions used: Lhx2 (rabbit, 1:2500); P- and E-cadherins (rat, 1:100); α6-integrin (rat, 1:100; Pharmingen); K5 (rabbit, 1:500); K1 (rabbit, 1:500); Filaggrin (rabbit, 1:500; Covance); β4-integrin (rat, 1:100; Pharmingen); CD34 (rat, 1:100; Pharmingen); Tenascin C (mouse, 1:500; IBL); S100A6 (rabbit, 1:100; Lab Vision); BrdU (rat, 1:500; Abcam); Tcf3 (guinea pig, 1:300); Sox9 (rabbit, 1:100; Santa Cruz); Lef1 (rabbit, 1:250); Gata3 (mouse, 1:100; Santa Cruz); K6 (rabbit, 1:500); AE13 and AE15 (mouse, 1:50); FITC (1:100; Jackson) or Alexa594 (1:1000; Molecular Probes) conjugated secondary Abs. Nuclei were stained using 4′6′-diamidino-2-phenylindole (DAPI). Imaging was performed using ZEISS AXIOSKOP and AXIOPHOT microscopes equipped with SPOT RT (Diagnostic Instruments) and AXIOCAM (ZEISS) digital cameras, respectively.

EXAMPLE 4

Isolation of Hair Progenitors and Flow Cytometry

Back skins from E17.5 K14-GFP embryos were dissected and treated overnight with dispase (Gibco, 0.4 mg/mL) at 4° C., which selectively removed the epidermis, hair placodes, and hair germs from the rest of the skin. This epidermal fraction was treated with 10 mM EDTA, and neutralized cell suspensions were strained (40 μM pores; BD Bioscience). Single cells were resuspended in PBS containing CaCl₂ and MgCl₂ (GIBCO) with 5% FBS, and incubated with primary antibodies coupled to biotin for 30 minutes on ice. After washing with PBS, cells were stained with streptavidin and antibodies directly conjugated to specific fluorophors for 30 minutes on ice. Cells were washed in PBS and resuspended in 300 ng/mL propidium iodide for dead cell exclusion. Cell isolations were performed on FACSVANTAGE SE system equipped with FACS DIVA software (BD Biosciences). Epidermal cells were gated for single events and viability, then sorted according to their expression of K14-GFP, α6-integrin, and P-cadherin. Purity of sorted cells was determined by post-sort FACS analysis and typically exceeded 95%. For grafted skin, single cell suspensions of total skin were isolated by dissecting the graft, mincing into small pieces, and sequential treatment with collagenase (SIGMA) and trypsin (GIBCO) at 37° C. Cells were strained and stained as above. Flow cytometry was performed on FACSORT equipped with CELLQUEST (BD Biosciences). Primary antibodies used for FACS: P-cadherin conjugated to biotin (1:100); α6-integrin coupled to APC or PE (1:100; Pharmingen); β4-integrin (1:100; Pharmingen) coupled to APC; CD34 conjugated to biotin (1:50; Pharmingen). BrdU detection was performed using BrdU Flow Kit (Pharmingen). Cytospin analysis was performed with a Cytospin4 unit (Thermo/Shandon), and stained according to standard methods.

EXAMPLE 5

RNA Isolation and Microarray Analyses

Total RNAs from FACS sorted cells were isolated and assessed for quality as described (Rendl, et al. (2005) PLOS Biol. 3:e331). Two rounds of amplification/labeling of 200 ng RNA was performed to obtain biotinylated cRNA for hybridization onto AFFYMETRIX GENECHIP Mouse Genome MOE430 2.0 oligonucleotide microarrays at the Genomics Core Laboratory of Memorial Sloan-Kettering Cancer Center (New York, USA). Two entirely independent samples were used for data analyses. Scanned microarray images were imported into Gene Chip Operating Software (GCOS, AFFYMETRIX) to generate signal values and present/absent calls for each probe set using the MAS 5.0 statistical expression algorithm. Each array was scaled to a target signal of 500 using default analysis parameters. Data files were imported into GENETRAFFIC 3.8 (Iobion Informatics), and replicate microarrays were grouped and compared using the Robust Multi-Chip Analysis algorithm. Genes represented with probe sets ≧2-fold increased in one population over the other and called present in both replicates were considered significant for further analysis.

EXAMPLE 6

Semi-Quantitative RT-PCR

Total RNA from FACS sorted cells was isolated as above, quantified with RIBOGREEN (Molecular Probes), and normalized RNA quantities were reverse transcribed with SUPERSCRIPT III using oligo-dT primers (INVITROGEN). PCR amplification of selected genes of interest was performed using primers designed to produce a product spanning exon/intron boundaries.

TABLE 1
Probe Set ID	UniGene Name	UniGene Symbol	Mean Log2 Ratio
1425425_a_at	Wnt inhibitory factor 1	Wif1	6.02
1455280_at	Fras1 related extracellular matrix protein 1	Frem1	5.15
1416846_a_at	PDZ domain containing RING finger 3	Pdzrn3	4.91
1427053_at	RIKEN cDNA 5033411B22 gene	5033411B22Rik	4.79
1449530_at	trichorhinophalangeal syndrome I (human)	Trps1	4.39
1427054_s_at	RIKEN cDNA 5033411B22 gene	5033411B22Rik	4.36
1416561_at	glutamic acid decarboxylase 1	Gad1	4.32
1434286_at	trichorhinophalangeal syndrome I (human)	Trps1	4.27
1418317_at	LIM homeobox protein 2	Lhx2	4.18
1435349_at	neuropilin 2	Nrp2	4.10
1446929_at	BTB and CNC homology 2 (Bach2), mRNA	Bach2	4.05
1437667_a_at	BTB and CNC homology 2	Bach2	4.03
1434195_at	protease, serine, 35	Prss35	3.96
1457445_at	trichorhinophalangeal syndrome I (human)	Trps1	3.90
1436869_at	sonic hedgehog	Shh	3.89
1440304_at	BTB and CNC homology 2 (Bach2), mRNA	Bach2	3.80
1427168_a_at	procollagen, type XIV, alpha 1	Col14a1	3.79
1450065_at	adenylate cyclase 7	Adcy7	3.79
1436515_at	RIKEN cDNA E030004N02 gene	E030004N02Rik	3.74
1438214_at	trichorhinophalangeal syndrome I (human)	Trps1	3.73
1448870_at	latent transforming growth factor beta binding protein 1	Ltbp1	3.73
1447343_at	neuropilin 2	Nrp2	3.72
1420753_at	tolloid-like	Tll1	3.70
1456307_s_at	adenylate cyclase 7	Adcy7	3.69
1426528_at	neuropilin 2	Nrp2	3.68
1455961_at	membrane metallo endopeptidase	Mme	3.64
1443161_at	Trichorhinophalangeal syndrome I (human)	Trps1	3.62
1442605_at	BTB and CNC homology 2 (Bach2), mRNA	Bach2	3.60
1438532_at	Similar to hemicentin; fibulin 6 (LOC240793), mRNA	NA	3.59
1440026_at	Trichorhinophalangeal syndrome I (human)	Trps1	3.55
1440339_at	RIKEN cDNA 4833416E15 gene	4833416E15Rik	3.55
1450922_a_at	transforming growth factor, beta 2	Tgfb2	3.52
1441657_at	BTB and CNC homology 2 (Bach2), mRNA	Bach2	3.51
1456778_at	neuropilin 2	Nrp2	3.50
1426640_s_at	tribbles homolog 2 (Drosophila)	Trib2	3.49
1428347_at	cytoplasmic FMR1 interacting protein 2	Cyfip2	3.41
1450923_at	transforming growth factor, beta 2	Tgfb2	3.41
1416967_at	SRY-box containing gene 2	Sox2	3.36
1436002_at	RIKEN cDNA C230013L11 gene	C230013L11Rik	3.34
1417155_at	neuroblastoma myc-related oncogene 1	Nmyc1	3.32
1426766_at	RIKEN cDNA 6330403K07 gene	6330403K07Rik	3.30
1434881_s_at	potassium channel tetramerisation domain containing 12	Kctd12	3.28
1447174_at	Dachshund 1 (Drosophila)	Dach1	3.28
1455865_at	insulinoma-associated 1	Insm1	3.28
1435399_at	RIKEN cDNA 2310068J10 gene	2310068J10Rik	3.27
1436555_at	expressed sequence AI158848	AI158848	3.23
1433743_at	dachshund 1 (Drosophila)	Dach1	3.22
1455277_at	Hedgehog-interacting protein	Hhip	3.17
1417336_a_at	synaptotagmin-like 4	Sytl4	3.15
1423250_a_at	transforming growth factor, beta 2	Tgfb2	3.14
1454613_at	Dihydropyrimidinase-like 3	Dpysl3	3.11
1436173_at	deleted in liver cancer 1	Dlc1	3.06
1440177_at	hypothetical protein 9630027E11	9.63E+17	3.02
1425874_at	homeo box C13	Hoxc13	2.95
1447227_at	Solute carrier family 40 (iron-regulated transporter), member 1	Slc40a1	2.94
1460602_at	deleted in liver cancer 1	Dlc1	2.94
1424683_at	RIKEN cDNA 1810015C04 gene	1810015C04Rik	2.91
1450988_at	G protein-coupled receptor 49	Gpr49	2.86
1437218_at	fibronectin 1	Fn1	2.84
1435396_at	expressed sequence C85317	C85317	2.81
1437360_at	Protocadherin 19	Pcdh19	2.81
1457042_at	Transcribed sequences	NA	2.81
1436329_at	early growth response 3	Egr3	2.79
1456901_at	A disintegrin-like and metalloprotease (reprolysin type) with thro	Adamts20	2.78
1429088_at	limb-bud and heart	Lbh	2.76
1450770_at	RIKEN cDNA 3632451O06 gene	3632451O06Rik	2.72
1436759_x_at	calponin 3, acidic	Cnn3	2.71
1443263_at	BTB and CNC homology 2 (Bach2), mRNA	Bach2	2.69
1456611_at	RIKEN cDNA D430015B01 gene	D430015B01Rik	2.69
1447831_s_at	myotubularin related protein 7	Mtmr7	2.66
1424704_at	runt related transcription factor 2	Runx2	2.65
1441956_s_at	Cut-like 1 (Drosophila), transcript variant 2, mRNA (cDNA clone	Cutl1	2.65
1458220_at	deleted in liver cancer 1	Dlc1	2.63
1423259_at	inhibitor of DNA binding 4	Id4	2.61
1446141_at	Transforming growth factor, beta 2	Tgfb2	2.60
1436836_x_at	calponin 3, acidic	Cnn3	2.58
1428572_at	brain abundant, membrane attached signal protein 1	Basp1	2.56
1425749_at	syntaxin binding protein 6 (amisyn)	Stxbp6	2.54
1443044_at	hypothetical A830091E24	A830091E24	2.54
1426642_at	fibronectin 1	Fn1	2.53
1437385_at	collagen and calcium binding EGF domains 1	Ccbe1	2.53
1419276_at	ectonucleotide pyrophosphatase/phosphodiesterase 1	Enpp1	2.52
1438303_at	transforming growth factor, beta 2	Tgfb2	2.51
1458739_at	Latent transforming growth factor beta binding protein 1	Ltbp1	2.51
1460578_at	FYVE, RhoGEF and PH domain containing 5	Fgd5	2.50
1436218_at	leucine-rich repeat-containing G protein-coupled receptor 6	Lgr6	2.49
1454830_at	fibrillin 2	Fbn2	2.48
1429549_at	procollagen, type XXVII, alpha 1	Col27a1	2.47
1455570_x_at	calponin 3, acidic	Cnn3	2.47
1429506_at	naked cuticle 1 homolog (Drosophila)	Nkd1	2.46
1450627_at	progressive ankylosis	ank	2.46
1420425_at	PR domain containing 1, with ZNF domain	Prdm1	2.45
1419724_at	ectodysplasin-A receptor	Edar	2.44
1428209_at	brain expressed X-linked 4	Bex4	2.42
1428896_at	platelet-derived growth factor receptor-like	Pdgfrl	2.42
1433490_s_at	erythrocyte protein band 4.1-like 2	Epb4.1l2	2.42
1440465_at	Cut-like 1 (Drosophila), transcript variant 2, mRNA (cDNA clone	Cutl1	2.42
1456380_x_at	calponin 3, acidic	Cnn3	2.42
1419485_at	forkhead box C1	Foxc1	2.41
1456211_at	NACHT, leucine rich repeat and PYD containing 10	Nalp10	2.41
1456292_a_at	vimentin	Vim	2.39
1450928_at	inhibitor of DNA binding 4	Id4	2.38
1455145_at	14, 17 days embryo head cDNA, RIKEN full-length enriched libr	NA	2.38
1423260_at	inhibitor of DNA binding 4	Id4	2.37
1444780_at	RIKEN cDNA 5330421F07 gene	5330421F07Rik	2.37
1454890_at	angiomotin	Amot	2.37
1459546_s_at	ectonucleotide pyrophosphatase/phosphodiesterase 1	Enpp1	2.37
1434909_at	Ras-related GTP binding D	Rragd	2.36
1422869_at	c-mer proto-oncogene tyrosine kinase	Mertk	2.35
1455256_at	TRAF2 and NCK interacting kinase	Tnik	2.34
1456111_at	hypothetical protein C130036J11	C130036J11	2.33
1423607_at	lumican	Lum	2.27
1434325_x_at	protein kinase, cAMP dependent regulatory, type I beta	Prkar1b	2.27
1439852_at	Transcribed sequences	NA	2.27
1454742_at	RasGEF domain family, member 1B	Rasgef1b	2.27
1433583_at	zinc finger protein 365	Zfp365	2.26
1416776_at	crystallin, mu	Crym	2.25
1417061_at	solute carrier family 40 (iron-regulated transporter), member 1	Slc40a1	2.25
1443544_at	Transcribed sequences	NA	2.25
1416221_at	follistatin-like 1	Fstl1	2.24
1417359_at	microfibrillar-associated protein 2	Mfap2	2.24
1438354_x_at	calponin 3, acidic	Cnn3	2.23
1438894_at	Transcribed sequences	NA	2.23
1440593_at	12 days embryo eyeball cDNA, RIKEN full-length enriched libra	NA	2.23
1434172_at	cannabinoid receptor 1 (brain)	Cnr1	2.22
1439468_at	BTB and CNC homology 2 (Bach2), mRNA	Bach2	2.22
1450505_a_at	RIKEN cDNA 1810015C04 gene	1810015C04Rik	2.22
1457859_at	ADP-ribosylation factor related protein 2	Arfrp2	2.22
1418028_at	dopachrome tautomerase	Dct	2.20
1418723_at	endothelial differentiation, lysophosphatidic acid G-protein-coup	Edg7	2.20
1438306_at	ring finger protein 180	Rnf180	2.20
1448259_at	follistatin-like 1	Fstl1	2.20
1422912_at	bone morphogenetic protein 4	Bmp4	2.19
1422643_at	monooxygenase, DBH-like 1	Moxd1	2.18
1439766_x_at	vascular endothelial growth factor C	Vegfc	2.17
1446525_at	Glypican 3, mRNA (cDNA clone MGC: 35964 IMAGE: 4973409)	Gpc3	2.17
1417111_at	mannosidase 1, alpha	Man1a	2.16
1438118_x_at	vimentin	Vim	2.16
1459619_at	erythrocyte protein band 4.1-like 2	Epb4.1l2	2.16
1428455_at	procollagen, type XIV, alpha 1	Col14a1	2.15
1422655_at	patched homolog 2	Ptch2	2.14
1434136_at	RIKEN cDNA 6332401O19 gene	6332401O19Rik	2.14
1449822_at	atonal homolog 1 (Drosophila)	Atoh1	2.14
1417377_at	immunoglobulin superfamily, member 4A	Igsf4a	2.12
1429178_at	odd Oz/ten-m homolog 3 (Drosophila)	Odz3	2.12
1434683_at	Cut-like 1 (Drosophila), transcript variant 2, mRNA (cDNA clone	Cutl1	2.12
1441539_at	0 day neonate lung cDNA, RIKEN full-length enriched library, cl	NA	2.12
1443240_at	Glypican 3, mRNA (cDNA clone MGC: 35964 IMAGE: 4973409)	Gpc3	2.12
1460604_at	cytochrome b reductase 1	Cybrd1	2.12
1437347_at	endothelin receptor type B	Ednrb	2.11
1438441_at	Inhibitor of DNA binding 4	Idb4	2.10
1452309_at	cingulin-like 1	Cgnl1	2.10
1458205_at	Mannosidase 1, alpha, mRNA (cDNA clone MGC: 18448 IMAGE	Man1a	2.10
1422592_at	catenin (cadherin associated protein), delta 2	Ctnnd2	2.09
1455180_at	expressed sequence AA407270	AA407270	2.09
1425447_at	dickkopf homolog 4 (Xenopus laevis)	Dkk4	2.08
1427025_at	myotubularin related protein 7	Mtmr7	2.08
1455262_at	Transcribed sequences	NA	2.08
1446088_at	RIKEN cDNA 9430081I23 gene	9430081I23Rik	2.07
1453851_a_at	growth arrest and DNA-damage-inducible 45 gamma	Gadd45g	2.07
1423274_at	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26	Ddx26	2.06
1423278_at	protein tyrosine phosphatase, receptor type, K	Ptprk	2.05
1418176_at	vitamin D receptor	Vdr	2.04
1422864_at	runt related transcription factor 1	Runx1	2.04
1439060_s_at	DNA segment, Chr 11, ERATO Doi 498, expressed	D11Ertd498e	2.04
1427086_at	CDNA clone IMAGE: 5028619, partial cds	NA	2.03
1433471_at	transcription factor 7, T-cell specific	Tcf7	2.03
1435280_at	expressed sequence AI452195	AI452195	2.03
1441779_at	RIKEN cDNA 9530006C21 gene	9530006C21Rik	2.03
1429870_at	RIKEN cDNA C630040K21 gene	C630040K21Rik	2.02
1455843_at	fucosyltransferase 4	Fut4	2.02
1459136_at	BTB and CNC homology 2 (Bach2), mRNA	Bach2	2.01
1417411_at	nucleosome assembly protein 1-like 5	Nap1l5	2.00
1417600_at	solute carrier family 15 (H+/peptide transporter), member 2	Slc15a2	2.00
1424098_at	ELOVL family member 7, elongation of long chain fatty acids (ye	Elovl7	2.00
1435720_at	Potassium voltage-gated channel, Shal-related family, member 3	Kcnd3	2.00
1438619_x_at	zinc finger, DHHC domain containing 14	Zdhhc14	2.00
1415949_at	carboxypeptidase E	Cpe	1.99
1436076_at	discs, large (Drosophila) homolog-associated protein 1	Dlgap1	1.99
1444432_at	RIKEN cDNA D330040H18 gene	D330040H18Rik	1.99
1446720_at	Activated leukocyte cell adhesion molecule	Alcam	1.99
1447567_at	Odd Oz/ten-m homolog 3 (Drosophila)	Odz3	1.99
1423091_a_at	glycoprotein m6b	Gpm6b	1.98
1450723_at	ISL1 transcription factor, LIM/homeodomain (islet 1)	Isl1	1.98
1452583_s_at	galactose mutarotase	Galm	1.98
1415834_at	dual specificity phosphatase 6	Dusp6	1.97
1422648_at	solute carrier family 7 (cationic amino acid transporter, y+ syste	Slc7a2	1.97
1436551_at	fibroblast growth factor receptor 1	Fgfr1	1.97
1436791_at	wingless-related MMTV integration site 5A	Wnt5a	1.97
1460431_at	glucosaminyl (N-acetyl) transferase 1, core 2	Gcnt1	1.97
1425779_a_at	T-box 1	Tbx1	1.96
1440372_at	ADP-ribosylation factor related protein 2	Arfrp2	1.96
1416632_at	malic enzyme, supernatant	Mod1	1.95
1458249_at	Transcribed sequence with weak similarity to protein ref: NP_08	NA	1.95
1424050_s_at	fibroblast growth factor receptor 1	Fgfr1	1.94
1445711_at	expressed sequence BB163080	BB163080	1.94
1442740_at	PR domain containing 5	Prdm5	1.93
1417376_a_at	immunoglobulin superfamily, member 4A	Igsf4a	1.92
1417400_at	retinoic acid induced 14	Rai14	1.92
1446247_at	a disintegrin-like and metalloprotease (reprolysin type) with thro	Adamts18	1.92
1448502_at	solute carrier family 16 (monocarboxylic acid transporters), mem	Slc16a7	1.92
1458605_at	ADP-ribosylation factor related protein 2	Arfrp2	1.92
1430264_at	RIKEN cDNA 2610030P05 gene	2610030P05Rik	1.91
1437466_at	activated leukocyte cell adhesion molecule	Alcam	1.91
1439554_at	sex comb on midleg homolog 1	Scmh1	1.91
1446609_at	Transcribed sequences	NA	1.91
1442504_at	0 day neonate thymus cDNA, RIKEN full-length enriched library,	NA	1.90
1448765_at	Fyn proto-oncogene	Fyn	1.90
1439753_x_at	sine oculis-related homeobox 4 homolog (Drosophila)	Six4	1.89
1426724_at	calponin 3, acidic	Cnn3	1.88
1431118_at	RIKEN cDNA 6720427H10 gene	6720427H10Rik	1.88
1444646_at	RIKEN cDNA 8430420F16 gene	8430420F16Rik	1.88
1449273_at	cytoplasmic FMR1 interacting protein 2	Cyfip2	1.88
1423584_at	insulin-like growth factor binding protein 7	Igfbp7	1.87
1437614_x_at	zinc finger, DHHC domain containing 14	Zdhhc14	1.86
1456621_at	RIKEN cDNA D430015B01 gene	D430015B01Rik	1.86
1438861_at	basonuclin 2	Bnc2	1.85
1441972_at	RIKEN cDNA 6230424C14 gene	6230424C14Rik	1.85
1416688_at	synaptosomal-associated protein 91	Snap91	1.84
1417378_at	immunoglobulin superfamily, member 4A	Igsf4a	1.84
1420965_a_at	ectodermal-neural cortex 1	Enc1	1.84
1437431_at	Cut-like 1 (Drosophila), transcript variant 2, mRNA (cDNA clone	Cutl1	1.84
1440878_at	runt related transcription factor 1	Runx1	1.84
1440312_at	ELOVL family member 7, elongation of long chain fatty acids (ye	Elovl7	1.83
1440586_at	RIKEN cDNA B430203I24 gene	B430203I24Rik	1.83
1448415_a_at	sema domain, immunoglobulin domain (Ig), short basic domain,	Sema3b	1.83
1417455_at	transforming growth factor, beta 3	Tgfb3	1.82
1441206_at	synaptopodin 2	Synpo2	1.81
1443158_at	Sex comb on midleg homolog 1	Scmh1	1.81
1443222_at	Thymoma viral proto-oncogene 3	Akt3	1.81
1449315_at	odd Oz/ten-m homolog 3 (Drosophila)	Odz3	1.81
1455447_at	RIKEN cDNA D430019H16 gene	D430019H16Rik	1.81
1428902_at	carbohydrate sulfotransferase 11	Chst11	1.80
1435832_at	leucine rich repeat containing 4	Lrrc4	1.80
1428479_at	nuclear factor of activated T-cells, cytoplasmic, calcineurin-depe	Nfatc1	1.79
1429359_s_at	RNA binding protein gene with multiple splicing	Rbpms	1.79
1436864_at	ADP-ribosylation factor related protein 2	Arfrp2	1.79
1444992_at	expressed sequence AI120166	AI120166	1.78
1434073_at	G protein-coupled receptor associated sorting protein 2	Gprasp2	1.77
1434180_at	pleckstrin homology domain containing, family C (with FERM do	Plekhc1	1.77
1436223_at	PREDICTED: integrin beta 8 [Mus musculus], mRNA sequence	Itgb8	1.77
1438896_at	DnaJ (Hsp40) homolog, subfamily C, member 6	Dnajc6	1.77
1439556_at	neural cell adhesion molecule 1	Ncam1	1.77
1439895_at	expressed sequence AU021025	AU021025	1.77
1447040_at	Activated leukocyte cell adhesion molecule	Alcam	1.77
1441644_at	Protein tyrosine phosphatase, receptor type, K	Ptprk	1.76
1417110_at	mannosidase 1, alpha	Man1a	1.75
1420667_at	double C2, beta	Doc2b	1.75
1422552_at	reprimo, TP53 dependent G2 arrest mediator candidate	Rprm	1.75
1423341_at	chondroitin sulfate proteoglycan 4	Cspg4	1.75
1436279_at	solute carrier family 26, member 7	Slc26a7	1.75
1453003_at	sortilin-related receptor, LDLR class A repeats-containing	Sorl1	1.75
1420731_a_at	cysteine and glycine-rich protein 2	Csrp2	1.74
1440770_at	B-cell leukemia/lymphoma 2	Bcl2	1.74
1455333_at	tensin 3	Tns3	1.74
1420589_at	hyaluronan synthase 3	Has3	1.73
1450191_a_at	SRY-box containing gene 13	Sox13	1.73
1419486_at	forkhead box C1	Foxc1	1.72
1421694_a_at	chondroitin sulfate proteoglycan 2	Cspg2	1.72
1422824_s_at	epidermal growth factor receptor pathway substrate 8	Eps8	1.72
1456862_at	sine oculis-related homeobox 4 homolog (Drosophila)	Six4	1.72
1417307_at	dystrophin, muscular dystrophy	Dmd	1.71
1421598_at	per-hexamer repeat gene 3	Phxr3	1.71
1429671_at	RIKEN cDNA 2410018M08 gene	2410018M08Rik	1.71
1438473_at	ADP-ribosylation factor related protein 2	Arfrp2	1.71
1441891_x_at	ELOVL family member 7, elongation of long chain fatty acids (ye	Elovl7	1.71
1455535_at	RIKEN cDNA A730017D01 gene	A730017D01Rik	1.71
1416165_at	RAB31, member RAS oncogene family	Rab31	1.70
1419700_a_at	prominin 1	Prom1	1.70
1440840_at	RIKEN cDNA D630004K10 gene	D630004K10Rik	1.70
1447204_at	Fibronectin leucine rich transmembrane protein 2	Flrt2	1.70
1416617_at	acyl-CoA synthetase short-chain family member 1	Acss1	1.69
1422831_at	fibrillin 2	Fbn2	1.69
1424097_at	ELOVL family member 7, elongation of long chain fatty acids (ye	Elovl7	1.69
1441573_at	sex comb on midleg homolog 1	Scmh1	1.69
1442467_at	RIKEN cDNA 5330421F07 gene	5330421F07Rik	1.69
1417585_at	nucleoporin 210	Nup210	1.68
1418847_at	arginase type II	Arg2	1.68
1423858_a_at	3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2	Hmgcs2	1.68
1434557_at	huntingtin interacting protein 1	Hip1	1.68
1438975_x_at	zinc finger, DHHC domain containing 14	Zdhhc14	1.68
1449033_at	tumor necrosis factor receptor superfamily, member 11b (osteop	Tnfrsf11b	1.68
1433699_at	tumor necrosis factor, alpha-induced protein 3	Tnfaip3	1.67
1435941_at	rhomboid, veinlet-like 4 (Drosophila)	Rhbdl4	1.67
1439191_at	follistatin-like 1	Fstl1	1.67
1441091_at	Transcribed sequences	NA	1.67
1458324_x_at	16 days embryo head cDNA, RIKEN full-length enriched library,	NA	1.67
1423407_a_at	fibulin 2	Fbln2	1.66
1433642_at	ADP-ribosylation factor related protein 2	Arfrp2	1.66
1454799_at	Transcribed sequences	NA	1.65
1420377_at	sialyltransferase 8 (alpha-2,8-sialyltransferase) B	Siat8b	1.64
1427256_at	chondroitin sulfate proteoglycan 2	Cspg2	1.64
1437967_at	Titin	Ttn	1.64
1446196_at	high mobility group AT-hook 2	Hmga2	1.64
1452366_at	RIKEN cDNA 4732435N03 gene	4732435N03Rik	1.64
1453514_at	glycoprotein m6b	Gpm6b	1.64
1418210_at	profilin 2	Pfn2	1.63
1443086_at	activated leukocyte cell adhesion molecule	Alcam	1.63
1422823_at	epidermal growth factor receptor pathway substrate 8	Eps8	1.62
1427257_at	chondroitin sulfate proteoglycan 2	Cspg2	1.62
1430307_a_at	malic enzyme, supernatant	Mod1	1.62
1438841_s_at	arginase type II	Arg2	1.62
1440354_at	ELOVL family member 7, elongation of long chain fatty acids (ye	Elovl7	1.62
1440678_at	Latent transforming growth factor beta binding protein 1	Ltbp1	1.62
1442680_at	Neural cell adhesion molecule 1	Ncam1	1.62
1453041_at	Trp53 inducible protein 5	Trp53i5	1.62
1423277_at	protein tyrosine phosphatase, receptor type, K	Ptprk	1.61
1443837_x_at	B-cell leukemia/lymphoma 2	Bcl2	1.61
1448566_at	solute carrier family 40 (iron-regulated transporter), member 1	Slc40a1	1.61
1426865_a_at	neural cell adhesion molecule 1	Ncam1	1.60
1429893_at	RIKEN cDNA 2810004A10 gene	2810004A10Rik	1.60
1433776_at	lipoma HMGIC fusion partner	Lhfp	1.60
1440758_at	7 days neonate cerebellum cDNA, RIKEN full-length enriched lib	NA	1.60
1443394_at	RIKEN cDNA 9230105E05 gene	9230105E05Rik	1.60
1447491_at	Leucine rich repeat containing 5	Lrrc5	1.60
1457275_at	desmuslin	Dmn	1.60
1416041_at	serum/glucocorticoid regulated kinase	Sgk	1.59
1417505_s_at	interleukin 11 receptor, alpha chain 1	Il11ra1	1.59
1443018_at	Neural cell adhesion molecule 1	Ncam1	1.59
1450061_at	ectodermal-neural cortex 1	Enc1	1.59
1453102_at	fibronectin leucine rich transmembrane protein 3	Flrt3	1.59
1453191_at	procollagen, type XXVII, alpha 1	Col27a1	1.59
1419044_at	contactin associated protein 4	Cntnap4	1.58
1426301_at	activated leukocyte cell adhesion molecule	Alcam	1.58
1427182_s_at	DNA segment, Chr 18, ERATO Doi 653, expressed	D18Ertd653e	1.58
1442174_at	tetraspanin 18	Tspan18	1.58
1417520_at	nuclear factor, erythroid derived 2, like 3	Nfe2l3	1.57
1417621_at	nuclear factor of activated T-cells, cytoplasmic, calcineurin-depe	Nfatc1	1.57
1425761_a_at	nuclear factor of activated T-cells, cytoplasmic, calcineurin-depe	Nfatc1	1.57
1437760_at	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalac	Galnt12	1.57
1450781_at	high mobility group AT-hook 2	Hmga2	1.57
1452287_at	Musashi homolog 1(Drosophila)	Msi1h	1.57
1421818_at	B-cell leukemia/lymphoma 6	Bcl6	1.56
1441769_at	ADP-ribosylation factor related protein 2	Arfrp2	1.56
1448788_at	antigen identified by monoclonal antibody MRC OX-2	Mox2	1.56
1457687_at	B-cell leukemia/lymphoma 2	Bcl2	1.56
1420928_at	beta galactoside alpha 2,6 sialyltransferase 1	St6gal1	1.55
1436501_at	mitochondrial tumor suppressor 1	Mtus1	1.55
1445211_at	Sex comb on midleg homolog 1	Scmh1	1.55
1419468_at	C-type lectin domain family 14, member a	Clec14a	1.54
1448877_at	distal-less homeobox 2	Dlx2	1.54
1451359_at	cDNA sequence BC005662	BC005662	1.54
1458113_at	RIKEN cDNA 9530019H20 gene	9530019H20Rik	1.54
1418175_at	vitamin D receptor	Vdr	1.53
1424114_s_at	laminin B1 subunit 1	Lamb1-1	1.53
1433596_at	DnaJ (Hsp40) homolog, subfamily C, member 6	Dnajc6	1.53
1451435_at	cut-like 1 (Drosophila)	Cutl1	1.53
1456404_at	a disintegrin-like and metalloprotease (reprolysin type) with thro	Adamts5	1.53
1457434_s_at	protein tyrosine phosphatase-like (proline instead of catalytic arg	Ptpla	1.52
1417319_at	poliovirus receptor-related 3	Pvrl3	1.51
1417780_at	longevity assurance homolog 4 (S. cerevisiae)	Lass4	1.51
1426864_a_at	neural cell adhesion molecule 1	Ncam1	1.51
1436959_x_at	nasal embryonic LHRH factor	Nelf	1.51
1444993_at	Ring finger protein 32	Rnf32	1.51
1460595_at	16 days embryo head cDNA, RIKEN full-length enriched library,	NA	1.51
1417673_at	growth factor receptor bound protein 14	Grb14	1.50
1424113_at	laminin B1 subunit 1	Lamb1-1	1.50
1442625_at	Transcribed sequence with weak similarity to protein ref: NP_08	NA	1.50
1424890_at	basonuclin 1	Bnc1	1.49
1426300_at	activated leukocyte cell adhesion molecule	Alcam	1.49
1436512_at	ADP-ribosylation factor-like 7	Arl7	1.49
1441391_at	Guanine nucleotide binding protein (G protein), beta polypeptide	Gnb1l	1.49
1455096_at	fibronectin leucine rich transmembrane protein 2	Flrt2	1.49
1428387_at	acyl-CoA synthetase long-chain family member 3	Acsl3	1.48
1430320_at	dystrophin, muscular dystrophy	Dmd	1.48
1448323_a_at	biglycan	Bgn	1.48
1450990_at	glypican 3	Gpc3	1.48
1460070_at	Carbohydrate sulfotransferase 2	Chst2	1.48
1423331_a_at	poliovirus receptor-related 3	Pvrl3	1.47
1425007_at	zinc finger protein 566	Zfp566	1.47
1439341_at	Transcribed sequences	NA	1.47
1441509_at	RIKEN cDNA A130009I22 gene	A130009I22Rik	1.47
1447547_at	latent transforming growth factor beta binding protein 1	Ltbp1	1.47
1459420_at	Transcribed sequences	NA	1.47
1418835_at	pleckstrin homology-like domain, family A, member 1	Phlda1	1.46
1429310_at	fibronectin leucine rich transmembrane protein 3	Flrt3	1.46
1433626_at	phospholipid scramblase 4	Plscr4	1.46
1434848_at	G protein-coupled receptor 27	Gpr27	1.46
1436419_a_at	RIKEN cDNA 1700097N02 gene	1700097N02Rik	1.46
1440555_at	Ras-related GTP binding D	Rragd	1.46
1448673_at	poliovirus receptor-related 3	Pvrl3	1.46
1449286_at	netrin G1	Ntng1	1.46
1450044_at	frizzled homolog 7 (Drosophila)	Fzd7	1.46
1416405_at	biglycan	Bgn	1.45
1436917_s_at	G-protein signalling modulator 1 (AGS3-like, C. elegans)	Gpsm1	1.45
1440506_at	Solute carrier family 7 (cationic amino acid transporter, y+ syste	Slc7a2	1.45
1451835_at	SRY-box containing gene 21	Sox21	1.45
1419470_at	guanine nucleotide binding protein, beta 4	Gnb4	1.44
1422708_at	phosphoinositide-3-kinase, catalytic, gamma polypeptide	Pik3cg	1.44
1439793_at	Gap junction membrane channel protein alpha 3 (Gja3), mRNA	Gja3	1.44
1443870_at	ATP-binding cassette, sub-family C (CFTR/MRP), member 4	Abcc4	1.44
1446380_at	RIKEN cDNA 9430076C15 gene	9430076C15Rik	1.44
1447295_at	Cut-like 1 (Drosophila), transcript variant 2, mRNA (cDNA clone	Cutl1	1.44
1450064_at	formin 2	Fmn2	1.44
1455995_at	DNA segment, Chr 10, Brigham & Women's Genetics 1379 expr	D10Bwg1379e	1.44
1456811_at	CXXC finger 4	Cxxc4	1.44
1420872_at	guanylate cyclase 1, soluble, beta 3	Gucy1b3	1.43
1430876_at	RIKEN cDNA 2610312I10 gene	2610312I10Rik	1.43
1443194_at	RIKEN cDNA 5930430O07 gene	5930430O07Rik	1.43
1453545_at	RIKEN cDNA 5730492I20 gene	5730492I20Rik	1.43
1426258_at	sortilin-related receptor, LDLR class A repeats-containing	Sorl1	1.42
1435701_at	10 days neonate medulla oblongata cDNA, RIKEN full-length en	NA	1.42
1442411_at	Glucocorticoid induced transcript 1	Glcci1	1.42
1454824_s_at	mitochondrial tumor suppressor 1	Mtus1	1.42
1437122_at	B-cell leukemia/lymphoma 2	Bcl2	1.41
1437422_at	sema domain, seven thrombospondin repeats (type 1 and type	Sema5a	1.41
1422851_at	high mobility group AT-hook 2	Hmga2	1.40
1437492_at	RIKEN cDNA 9430023B20 gene	9430023B20Rik	1.40
1442992_at	hypothetical LOC403343	130004C03	1.40
1444763_at	protein tyrosine phosphatase, receptor type, K	Ptprk	1.40
1446583_at	NA	NA	1.40
1448557_at	RIKEN cDNA 1200015N20 gene	1200015N20Rik	1.40
1454866_s_at	chloride intracellular channel 6	Clic6	1.40
1434776_at	sema domain, seven thrombospondin repeats (type 1 and type	Sema5a	1.39
1435207_at	DIX domain containing 1	Dixdc1	1.39
1437403_at	RIKEN cDNA E130306M17 gene	E130306M17Rik	1.39
1443827_x_at	cDNA sequence BC004044	BC004044	1.39
1416892_s_at	RIKEN cDNA 3110001A13 gene	3110001A13Rik	1.38
1438989_s_at	RIKEN cDNA B130021B11 gene	B130021B11Rik	1.38
1456315_a_at	protein tyrosine phosphatase-like (proline instead of catalytic arg	Ptpla	1.38
1418608_at	calmodulin-like 3	Calml3	1.37
1426858_at	inhibin beta-B	Inhbb	1.37
1433779_at	cancer susceptibility candidate 4	Casc4	1.37
1445697_at	Similar to development- and differentiation-enhancing factor 2; F	—	1.37
1451899_a_at	general transcription factor II I repeat domain-containing 1	Gtf2ird1	1.37
1456095_at	Tyrosinase (Tyr), mRNA	Tyr	1.37
1427579_at	rhomboid, veinlet-like 4 (Drosophila)	Rhbdl4	1.36
1429987_at	RIKEN cDNA 9930013L23 gene	9930013L23Rik	1.36
1435892_at	RIKEN cDNA D430002O22 gene	D430002O22Rik	1.36
1437574_at	a disintegrin-like and metalloprotease (reprolysin type) with thror	Adamts18	1.36
1441947_x_at	cDNA sequence BC033915	BC033915	1.36
1446772_at	Transcribed sequences	NA	1.36
1423110_at	procollagen, type I, alpha 2	Col1a2	1.35
1439795_at	G protein-coupled receptor 64	Gpr64	1.35
1448665_at	dystrophin, muscular dystrophy	Dmd	1.35
1448698_at	cyclin D1	Ccnd1	1.35
1460364_at	general transcription factor II I repeat domain-containing 1	Gtf2ird1	1.35
1448669_at	dickkopf homolog 3 (Xenopus laevis)	Dkk3	1.34
1417937_at	dapper homolog 1, antagonist of beta-catenin (xenopus)	Dact1	1.33
1426008_a_at	solute carrier family 7 (cationic amino acid transporter, y+ syste	Slc7a2	1.33
1456515_s_at	transcription factor-like 5 (basic helix-loop-helix)	Tcfl5	1.33
1436993_x_at	profilin 2	Pfn2	1.32
1438702_at	fibronectin leucine rich transmembrane protein 2	Flrt2	1.32
1452106_at	nephronectin	Npnt	1.32
1455436_at	DIRAS family, GTP-binding RAS-like 2	Diras2	1.32
1417782_at	longevity assurance homolog 4 (S. cerevisiae)	Lass4	1.31
1423635_at	bone morphogenetic protein 2	Bmp2	1.31
1429001_at	pirin	Pir	1.31
1444306_at	Musashi homolog 1(Drosophila)	Msi1h	1.31
1448901_at	carboxypeptidase X 1 (M14 family)	Cpxm1	1.31
1429053_at	RIKEN cDNA 1110012J17 gene	1110012J17Rik	1.30
1429285_at	serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antipro	Serpina9	1.30
1434709_at	RIKEN cDNA C130076O07 gene	C130076O07Rik	1.30
1436181_at	development and differentiation enhancing factor 2	Ddef2	1.30
1453595_at	RIKEN cDNA 2900064B18 gene	2900064B18Rik	1.30
1454788_at	ADP-ribosylation factor-like 7	Arl7	1.30
1455325_at	RIKEN cDNA A230057G18 gene	A230057G18Rik	1.30
1458947_at	Fanconi anemia, complementation group C	Fancc	1.30
1424625_a_at	DENN/MADD domain containing 1A	Dennd1a	1.29
1432103_a_at	SH3-domain GRB2-like 3	Sh3gl3	1.29
1434628_a_at	rhophilin, Rho GTPase binding protein 2	Rhpn2	1.29
1436761_s_at	RIKEN cDNA 1200015N20 gene	1200015N20Rik	1.29
1437889_x_at	biglycan	Bgn	1.29
1431202_at	hect domain and RLD 3	Herc3	1.28
1416842_at	glutathione S-transferase, mu 5	Gstm5	1.27
1423885_at	laminin, gamma 1	Lamc1	1.27
1429514_at	phosphatidic acid phosphatase type 2B	Ppap2b	1.27
1431049_at	amyotrophic lateral sclerosis 2 (juvenile) chromosome region, ca	Als2cr15	1.27
1451972_at	glucocorticoid induced transcript 1	Glcci1	1.27
1452771_s_at	acyl-CoA synthetase long-chain family member 3	Acsl3	1.27
1416257_at	calpain 2	Capn2	1.26
1421317_x_at	myeloblastosis oncogene	Myb	1.26
1428259_at	RIKEN cDNA 2310075M15 gene	2310075M15Rik	1.26
1431300_at	SH3-domain GRB2-like (endophilin) interacting protein 1	Sgip1	1.26
1450194_a_at	myeloblastosis oncogene	Myb	1.26
1454764_s_at	solute carrier family 38, member 1	Slc38a1	1.26
1455549_at	SEC14 and spectrin domains 1	Sestd1	1.26
1434496_at	polo-like kinase 3 (Drosophila)	Plk3	1.25
1452365_at	RIKEN cDNA 4732435N03 gene	4732435N03Rik	1.25
1417686_at	lectin, galactose binding, soluble 12	Lgals12	1.24
1418209_a_at	profilin 2	Pfn2	1.24
1434429_at	synaptotagmin 14-like	Syt14l	1.24
1441463_at	RIKEN cDNA C230079D11 gene	C230079D11Rik	1.24
1455250_at	SH3-domain binding protein 4	Sh3bp4	1.24
1436508_at	RIKEN cDNA 2410014A08 gene	2410014A08Rik	1.23
1450857_a_at	procollagen, type I, alpha 2	Col1a2	1.23
1426317_at	StAR-related lipid transfer (START) domain containing 6	Stard6	1.22
1436509_at	RIKEN cDNA 2410014A08 gene	2410014A08Rik	1.22
1441927_at	synaptotagmin 7	Syt7	1.22
1452214_at	SKI-like	Skil	1.22
1454576_at	RIKEN cDNA A230102021 gene	A230102O21Rik	1.22
1455818_at	RIKEN cDNA 4930427A07 gene	4930427A07Rik	1.22
1456874_at	fibronectin leucine rich transmembrane protein 2	Flrt2	1.22
1458140_at	slit homolog 2 (Drosophila)	Slit2	1.22
1426218_at	glucocorticoid induced transcript 1	Glcci1	1.21
1433043_at	chondroitin sulfate proteoglycan 2	Cspg2	1.21
1450860_at	leucine aminopeptidase 3	Lap3	1.21
1452107_s_at	nephronectin	Npnt	1.21
1459868_x_at	interleukin 11 receptor, alpha chain 1	Il11ra1	1.21
1417420_at	cyclin D1	Ccnd1	1.20
1421052_a_at	spermine synthase	Sms	1.20
1430934_at	RIKEN cDNA 2810043G22 gene	2810043G22Rik	1.20
1445178_at	SH3 multiple domains 2	Sh3md2	1.20
1449630_s_at	MAP/microtubule affinity-regulating kinase 1	Mark1	1.20
1454877_at	SERTA domain containing 4	Sertad4	1.20
1417311_at	cysteine rich protein 2	Crip2	1.19
1425942_a_at	glycoprotein m6b	Gpm6b	1.19
1442845_at	RIKEN cDNA C130075A20 gene	C130075A20Rik	1.19
1443589_at	DNA segment, Chr X, ERATO Doi 242, expressed	DXErtd242e	1.19
1446850_at	Phosphatidic acid phosphatase type 2B	Ppap2b	1.19
1448569_at	CD8 antigen, beta chain	Cd8b	1.19
1450780_s_at	high mobility group AT-hook 2	Hmga2	1.19
1457113_at	nuclear autoantigenic sperm protein (histone-binding)	Nasp	1.19
1416489_at	phosphatidylinositol 4-kinase type 2 beta	Pi4k2b	1.18
1435363_at	pleckstrin homology domain containing, family G (with RhoGef d	Plekhg1	1.18
1441038_at	Utrophin	Utrn	1.18
1452666_a_at	transmembrane and coiled-coil domains 2	Tmcc2	1.18
1454268_a_at	cytochrome b-245, alpha polypeptide	Cyba	1.18
1455214_at	microphthalmia-associated transcription factor	Mitf	1.18
1440952_at	MAD homolog 7 (Drosophila)	Smad7	1.17
1444253_at	a disintegrin-like and metalloprotease (reprolysin type) with thror	Adamts18	1.17
1451679_at	RIKEN cDNA 6530401D17 gene	6530401D17Rik	1.17
1455437_at	cDNA sequence BC033915	BC033915	1.17
1423680_at	fatty acid desaturase 1	Fads1	1.16
1426241_a_at	sex comb on midleg homolog 1	Scmh1	1.16
1440513_at	expressed sequence C80258	C80258	1.16
1445918_at	transmembrane protein 2	Tmem2	1.16
1449455_at	hemopoietic cell kinase	Hck	1.16
1458942_at	RIKEN cDNA C230037E05 gene	C230037E05Rik	1.16
1460693_a_at	procollagen, type IX, alpha 3	Col9a3	1.16
1416579_a_at	tumor-associated calcium signal transducer 1	Tacstd1	1.15
1416953_at	connective tissue growth factor	Ctgf	1.15
1424824_at	RIKEN cDNA 9630044O09 gene	9630044O09Rik	1.15
1433491_at	erythrocyte protein band 4.1-like 2	Epb4.1l2	1.15
1436977_at	Transcribed sequences	NA	1.15
1440284_at	Transcribed sequences	NA	1.15
1452226_at	regulator of chromosome condensation 2	Rcc2	1.15
1454701_at	RIKEN cDNA 4930503L19 gene	4930503L19Rik	1.15
1456072_at	protein phosphatase 1, regulatory (inhibitor) subunit 9A	Ppp1r9a	1.15
1419798_at	RIKEN cDNA 2610019E17 gene	2610019E17Rik	1.14
1427028_at	leucine-rich repeat-containing G protein-coupled receptor 6	Lgr6	1.14
1431226_a_at	fibronectin type III domain containing 4	Fndc4	1.14
1434307_at	transmembrane protein 64	Tmem64	1.14
1438783_at	Transmembrane, prostate androgen induced RNA	Tmepai	1.14
1442175_at	RIKEN cDNA C030027H14 gene	C030027H14Rik	1.14
1447043_at	V-erb-a erythroblastic leukemia viral oncogene homolog 4 (avia	Erbb4	1.14
1451516_at	Ras homolog enriched in brain like 1	Rhebl1	1.14
1456648_at	Mannosidase 1, alpha	Man1a	1.14
1459144_at	Fibronectin type III domain containing 3a	Fndc3	1.14
1429896_at	RIKEN cDNA 5830408B19 gene	5830408B19Rik	1.13
1433894_at	expressed sequence AI591476	AI591476	1.13
1437785_at	a disintegrin-like and metalloprotease (reprolysin type) with thro	Adamts9	1.13
1446461_at	SRY-box containing gene 5	Sox5	1.13
1453416_at	growth arrest-specific 2 like 3	Gas2l3	1.13
1423499_at	synuclein, alpha interacting protein (synphilin)	Sncaip	1.12
1424367_a_at	homer homolog 2 (Drosophila)	Homer2	1.12
1430033_at	RIKEN cDNA 5330431K02 gene	5330431K02Rik	1.12
1437059_at	SRY-box containing gene 21	Sox21	1.12
1437467_at	activated leukocyte cell adhesion molecule	Alcam	1.12
1439568_at	gene regulated by estrogen in breast cancer protein	Greb1	1.12
1446653_at	Transcribed sequences	NA	1.12
1448919_at	CD302 antigen	Cd302	1.12
1430352_at	RIKEN cDNA 8430417A20 gene	8430417A20Rik	1.11
1431402_at	kin of IRRE like 3 (Drosophila)	Kirrel3	1.11
1433590_at	hect domain and RLD 3	Herc3	1.11
1435083_at	cortexin	Ctxn	1.11
1435176_a_at	inhibitor of DNA binding 2	Id2	1.11
1459493_at	SET binding protein 1 (Setbp1), mRNA	Setbp1	1.11
1430083_at	RIKEN cDNA 2610307P16 gene	2610307P16Rik	1.10
1440739_at	vascular endothelial growth factor C	Vegfc	1.10
1420411_a_at	phosphatidylinositol 4-kinase type 2 beta	Pi4k2b	1.09
1422865_at	runt related transcription factor 1	Runx1	1.09
1434645_at	RIKEN cDNA C530008M17 gene	C530008M17Rik	1.09
1434797_at	RIKEN cDNA 6720469N11 gene	6720469N11Rik	1.09
1435050_at	RIKEN cDNA B930094H20 gene	B930094H20Rik	1.09
1435977_at	hepatoma-derived growth factor, related protein 3	Hdgfrp3	1.09
1438866_at	glutamate receptor ionotropic, NMDA3A	Grin3a	1.09
1446897_at	Transcribed sequences	NA	1.09
1448024_at	RIKEN cDNA B430320C24 gene	B430320C24Rik	1.09
1458241_at	RIKEN cDNA 9230105E05 gene	9230105E05Rik	1.09
1419829_a_at	Transcribed sequence with weak similarity to protein prf: 201819	NA	1.08
1435387_at	expressed sequence AI505012	AI505012	1.08
1447818_x_at	Ras homolog enriched in brain like 1	Rhebl1	1.08
1449058_at	GLI-Kruppel family member GLI1	Gli1	1.08
1449471_at	potassium large conductance calcium-activated channel, subfam	Kcnmb4	1.08
1456377_x_at	RIKEN cDNA 0610025L06 gene	0610025L06Rik	1.08
1460559_at	ankyrin repeat domain 25	Ankrd25	1.08
1417312_at	dickkopf homolog 3 (Xenopus laevis)	Dkk3	1.07
1418711_at	platelet derived growth factor, alpha	Pdgfa	1.07
1420342_at	ganglioside-induced differentiation-associated-protein 10	Gdap10	1.07
1422462_at	ubiquitin-conjugating enzyme E2T (putative)	Ube2t	1.07
1424250_a_at	Rho guanine nucleotide exchange factor (GEF) 3	Arhgef3	1.07
1426934_at	NHS-like 1	Nhsl1	1.07
1433531_at	acyl-CoA synthetase long-chain family member 4	Acsl4	1.07
1434982_at	Transcribed sequence with weak similarity to protein pir: S07330	NA	1.07
1440067_at	Neural cell adhesion molecule 1	Ncam1	1.07
1418884_x_at	tubulin, alpha 1	Tuba1	1.06
1424051_at	procollagen, type IV, alpha 2	Col4a2	1.06
1424950_at	SRY-box containing gene 9	Sox9	1.06
1425452_s_at	protein tyrosine phosphatase, receptor type, J /// expressed seq	Ptprj /// AW125753	1.06
1425510_at	MAP/microtubule affinity-regulating kinase 1	Mark1	1.06
1426541_a_at	RIKEN cDNA 2310067E08 gene	2310067E08Rik	1.06
1434592_at	solute carrier family 16 (monocarboxylic acid transporters), mem	Slc16a10	1.06
1435184_at	RIKEN cDNA B430320C24 gene	B430320C24Rik	1.06
1452205_x_at	T-cell receptor beta, variable 13	Tcrb-V13	1.06
1452740_at	myosin heavy chain 10, non-muscle	Myh10	1.06
1457256_x_at	patched homolog 2	Ptch2	1.06
1416505_at	nuclear receptor subfamily 4, group A, member 1	Nr4a1	1.05
1417101_at	heat shock protein 2	Hspa2	1.05
1417558_at	Fyn proto-oncogene	Fyn	1.05
1421943_at	transforming growth factor alpha	Tgfa	1.05
1422771_at	MAD homolog 6 (Drosophila)	Smad6	1.05
1427683_at	early growth response 2	Egr2	1.05
1429114_at	SEC14 and spectrin domains 1	Sestd1	1.05
1435913_at	cDNA sequence BC038881	BC038881	1.05
1454671_at	insulin induced gene 1	Insig1	1.05
1460627_at	RIKEN cDNA D130067I03 gene	D130067I03Rik	1.05
1417612_at	immediate early response 5	Ier5	1.04
1417978_at	eukaryotic translation initiation factor 4E member 3	Eif4e3	1.04
1424594_at	lectin, galactose binding, soluble 7	Lgals7	1.04
1434700_at	RIKEN cDNA 6030408C04 gene	6030408C04Rik	1.04
1435308_at	fucosyltransferase 9	Fut9	1.04
1444519_at	G protein-coupled receptor 49	Gpr49	1.04
1448416_at	matrix gamma-carboxyglutamate (gla) protein	Mglap	1.04
1455820_x_at	scavenger receptor class B, member 1	Scarb1	1.04
1458575_at	SET binding protein 1 (Setbp1), mRNA	Setbp1	1.04
1415806_at	plasminogen activator, tissue	Plat	1.03
1434008_at	sodium channel, type IV, beta polypeptide	Scn4b	1.03
1435461_at	membrane associated guanylate kinase, WW and PDZ domain	Magi3	1.03
1436368_at	solute carrier family 16 (monocarboxylic acid transporters), mem	Slc16a10	1.03
1439926_at	hypothetical protein 4632417D23	4632417D23	1.03
1455881_at	immediate early response 5-like	Ier5l	1.03
1415964_at	stearoyl-Coenzyme A desaturase 1	Scd1	1.02
1417688_at	cDNA sequence BC004044	BC004044	1.02
1417749_a_at	tight junction protein 1	Tjp1	1.02
1432746_at	RIKEN cDNA 6030442H21 gene	6030442H21Rik	1.02
1437540_at	mucolipin 3	Mcoln3	1.02
1444583_at	Nuclear autoantigenic sperm protein (histone-binding)	Nasp	1.02
1448509_at	SH3-domain GRB2-like (endophilin) interacting protein 1	Sgip1	1.02
1451152_a_at	ATPase, Na+/K+ transporting, beta 1 polypeptide	Atp1b1	1.02
1455149_at	SH3 multiple domains 2	Sh3md2	1.02
1456475_s_at	protein kinase, cAMP dependent regulatory, type II beta	Prkar2b	1.02
1416326_at	cysteine-rich protein 1 (intestinal)	Crip1	1.01
1417928_at	PDZ and LIM domain 4	Pdlim4	1.01
1419593_at	gene regulated by estrogen in breast cancer protein	Greb1	1.01
1433571_at	serine incorporator 5	Serinc5	1.01
1433770_at	dihydropyrimidinase-like 2	Dpysl2	1.01
1441995_at	Neural cell adhesion molecule 1	Ncam1	1.01
1448908_at	phosphatidic acid phosphatase type 2B	Ppap2b	1.01
1455687_at	intestinal cell kinase	Ick	1.01
1455980_a_at	PREDICTED: similar to growth arrest-specific 2 like 3 [Mus mus	Gas2l3	1.01
1457229_at	G-protein coupled receptor 173	Gpr173	1.01
1459054_at	cDNA sequence BC035954	BC035954	1.01
1426712_at	solute carrier family 6 (neurotransmitter transporter), member 15	Slc6a15	1.00
1428749_at	Dmx-like 2	Dmxl2	1.00
1437894_at	prospero-related homeobox 1	Prox1	1.00
1438664_at	protein kinase, cAMP dependent regulatory, type II beta	Prkar2b	1.00
1446326_at	procollagen, type I, alpha 2	Col1a2	1.00
1449198_a_at	sialyltransferase 9 (CMP-NeuAc:lactosylceramide alpha-2,3-sial	Siat9	1.00
1453523_at	RIKEN cDNA A030006P16 gene	A030006P16Rik	1.00
1419161_a_at	NADPH oxidase 4	Nox4	−1.00
1419309_at	podoplanin	Pdpn	−1.00
1426584_a_at	sorbitol dehydrogenase 1	Sdh1	−1.00
1428549_at	coiled-coil domain containing 3	Ccdc3	−1.00
1429021_at	Eph receptor A4	Epha4	−1.00
1429581_at	acyl-Coenzyme A dehydrogenase family, member 9	Acad9	−1.00
1430191_at	RIKEN cDNA 9130004J05 gene	9130004J05Rik	−1.00
1439731_at	RIKEN cDNA E130309F12 gene	E130309F12Rik	−1.00
1445897_s_at	interferon-induced protein 35	Ifi35	−1.00
1451243_at	arginyl aminopeptidase (aminopeptidase B)	Rnpep	−1.00
1416137_at	annexin A7	Anxa7	−1.01
1416401_at	kangai 1 (suppression of tumorigenicity 6, prostate)	Kai1	−1.01
1417701_at	protein phosphatase 1, regulatory (inhibitor) subunit 14c	Ppp1r14c	−1.01
1422470_at	BCL2/adenovirus E1B 19 kDa-interacting protein 1, NIP3	Bnip3	−1.01
1424172_at	hydroxyacyl glutathione hydrolase	Hagh	−1.01
1427510_at	guanine nucleotide binding protein, alpha inhibiting 1	Gnai1	−1.01
1430286_s_at	protein phosphatase 1, regulatory (inhibitor) subunit 14c	Ppp1r14c	−1.01
1449256_a_at	RAB11a, member RAS oncogene family	Rab11a	−1.01
1452434_s_at	DiGeorge syndrome critical region gene 6	Dgcr6	−1.01
1452519_a_at	zinc finger protein 36	Zfp36	−1.01
1453261_at	RIKEN cDNA 2610035D17 gene	2610035D17Rik	−1.01
1416021_a_at	fatty acid binding protein 5, epidermal	Fabp5	−1.02
1417195_at	DNA segment, Chr 8, ERATO Doi 594, expressed	D8Ertd594e	−1.02
1417649_at	cyclin-dependent kinase inhibitor 1C (P57)	Cdkn1c	−1.02
1420150_at	splA/ryanodine receptor domain and SOCS box containing 1	Spsb1	−1.02
1422743_at	phosphorylase kinase alpha 1	Phka1	−1.02
1423420_at	adrenergic receptor, beta 1	Adrb1	−1.02
1423909_at	RIKEN cDNA 0610011I04 gene	0610011I04Rik	−1.02
1426873_s_at	junction plakoglobin	Jup	−1.02
1438764_at	annexin A7	Anxa7	−1.02
1419052_at	OVO homolog-like 1 (Drosophila)	Ovol1	−1.03
1435205_at	transcription factor AP-2, epsilon	Tcfap2e	−1.03
1435571_at	RIKEN cDNA A530065I17 gene	A530065I17Rik	−1.03
1438093_x_at	diazepam binding inhibitor	Dbi	−1.03
1442606_at	dynamin binding protein	Dnmbp	−1.03
1455994_x_at	elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3	Elovl1	−1.03
1457883_at	Adult male aorta and vein cDNA, RIKEN full-length enriched libr	NA	−1.03
1459948_at	Growth hormone receptor	Ghr	−1.03
1418517_at	Iroquois related homeobox 3 (Drosophila)	Irx3	−1.04
1421106_at	jagged 1	Jag1	−1.04
1424530_at	SEC14-like 2 (S. cerevisiae)	Sec14l2	−1.04
1425645_s_at	cytochrome P450, family 2, subfamily b, polypeptide 20	Cyp2b20	−1.04
1430483_a_at	RIKEN cDNA 2310042N02 gene	2310042N02Rik	−1.04
1430655_at	RIKEN cDNA 4631405K08 gene	4631405K08Rik	−1.04
1441547_at	Nuclear factor I/A	Nfia	−1.04
1446281_at	RIKEN cDNA C530008M07 gene	C530008M07Rik	−1.04
1449852_a_at	EH-domain containing 4	Ehd4	−1.04
1423494_at	RIKEN cDNA 2310042E22 gene	2310042E22Rik	−1.05
1428400_at	RIKEN cDNA 2200002K05 gene	2200002K05Rik	−1.05
1430724_at	abhydrolase domain containing 9	Abhd9	−1.05
1432018_at	achaete-scute complex homolog-like 2 (Drosophila)	Ascl2	−1.05
1433943_at	RIKEN cDNA 4930463G05 gene	4930463G05Rik	−1.05
1448529_at	thrombomodulin	Thbd	−1.05
1450034_at	signal transducer and activator of transcription 1	Stat1	−1.05
1451210_at	phosphatidic acid phosphatase type 2c	Ppap2c	−1.05
1417047_at	prominin 2	Prom2	−1.06
1417196_s_at	DNA segment, Chr 8, ERATO Doi 594, expressed	D8Ertd594e	−1.06
1425603_at	RIKEN cDNA 0610011I04 gene	0610011I04Rik	−1.06
1448194_a_at	H19 fetal liver mRNA	H19	−1.06
1453511_at	RIKEN cDNA 2310007B03 gene	2310007B03Rik	−1.06
1458578_at	RNA binding motif, single stranded interacting protein 1, mRNA	Rbms1	−1.06
1417301_at	frizzled homolog 6 (Drosophila)	Fzd6	−1.07
1422784_at	keratin complex 2, basic, gene 6a	Krt2-6a	−1.07
1424308_at	solute carrier family 24 (sodium/potassium/calcium exchanger),	Slc24a3	−1.07
1425918_at	EGL nine homolog 3 (C. elegans)	Egln3	−1.07
1438937_x_at	angiogenin, ribonuclease A family, member 1	Ang1	−1.07
1448985_at	dual specificity phosphatase 22	Dusp22	−1.07
1450626_at	mannosidase, beta A, lysosomal	Manba	−1.07
1453593_at	RIKEN cDNA 1700110N18 gene	1700110N18Rik	−1.07
1416431_at	tubulin, beta 6	Tubb6	−1.08
1417395_at	Kruppel-like factor 4 (gut)	Klf4	−1.08
1420614_at	t-complex-associated-testis-expressed 1-like	Tcte1l	−1.08
1424400_a_at	formyltetrahydrofolate dehydrogenase	Fthfd	−1.08
1428450_at	RIKEN cDNA 2610034B18 gene	2610034B18Rik	−1.08
1437057_at	EGF-like-domain, multiple 3	Egfl3	−1.08
1437245_at	RIKEN cDNA 9930117H01 gene	9930117H01Rik	−1.08
1439757_s_at	Eph receptor A4	Epha4	−1.08
1440693_at	RIKEN cDNA 2410003B16 gene	2410003B16Rik	−1.08
1443720_s_at	bone morphogenetic protein receptor, type 1B	Bmpr1b	−1.08
1445929_at	Potassium channel, subfamily K, member 2	Kcnk2	−1.08
1415850_at	RAS p21 protein activator 3	Rasa3	−1.09
1417777_at	leukotriene B4 12-hydroxydehydrogenase	Ltb4dh	−1.09
1418483_a_at	glycoprotein galactosyltransferase alpha 1, 3	Ggta1	−1.09
1418648_at	EGL nine homolog 3 (C. elegans)	Egln3	−1.09
1420498_a_at	disabled homolog 2 (Drosophila)	Dab2	−1.09
1422293_a_at	potassium channel tetramerisation domain containing 1	Kctd1	−1.09
1423126_at	ATPase, Na+/K+ transporting, beta 3 polypeptide	Atp1b3	−1.09
1424507_at	Ras and Rab interactor 1	Rin1	−1.09
1434440_at	guanine nucleotide binding protein, alpha inhibiting 1	Gnai1	−1.09
1434725_at	RIKEN cDNA 4921521N14 gene	4921521N14Rik	−1.09
1436346_at	CD109 antigen	Cd109	−1.09
1440283_at	RIKEN cDNA 1810059H22 gene	1810059H22Rik	−1.09
1441163_at	mediator of RNA polymerase II transcription, subunit 12 homolog	Med12l	−1.09
1447655_x_at	SRY-box containing gene 6	Sox6	−1.09
1448954_at	nuclear receptor interacting protein 3	Nrip3	−1.09
1449929_at	t-complex-associated-testis-expressed 1-like	Tcte1l	−1.09
1450947_at	RIKEN cDNA 2610528J11 gene	2610528J11Rik	−1.09
1416528_at	SH3 domain binding glutamic acid-rich protein-like 3	Sh3bgrl3	−1.10
1424030_at	grainyhead-like 1 (Drosophila)	Grhl1	−1.10
1424942_a_at	myelocytomatosis oncogene	Myc	−1.10
1429284_at	RIKEN cDNA 8430436F23 gene	8430436F23Rik	−1.10
1434534_at	NA	NA	−1.10
1437874_s_at	hexosaminidase B	Hexb	−1.10
1444974_at	expressed sequence AU023617	AU023617	−1.10
1451594_s_at	serine (or cysteine) proteinase inhibitor, clade B, member 6c	Serpinb6c	−1.10
1416564_at	SRY-box containing gene 7	Sox7	−1.11
1427677_a_at	SRY-box containing gene 6	Sox6	−1.11
1436651_at	Transcribed sequences	NA	−1.11
1438882_at	Rho GTPase activating protein 18	Arhgap18	−1.11
1439352_at	tripartite motif protein 7	Trim7	−1.11
1454862_at	pleckstrin homology-like domain, family B, member 2	Phldb2	−1.11
1417122_at	vav 3 oncogene	Vav3	−1.12
1419572_a_at	ATP-binding cassette, sub-family D (ALD), member 4	Abcd4	−1.12
1424303_at	expressed sequence AV216087	AV216087	−1.12
1425108_a_at	cDNA sequence BC004728	B0004728	−1.12
1426908_at	UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgala	Galnt7	−1.12
1441153_at	Utrophin	Utrn	−1.12
1443997_at	RIKEN cDNA C130040D06 gene	C130040D06Rik	−1.12
1416008_at	special AT-rich sequence binding protein 1	Satb1	−1.13
1417813_at	inhibitor of kappaB kinase epsilon	Ikbke	−1.13
1421163_a_at	nuclear factor I/A	Nfia	−1.13
1434070_at	jagged 1	Jag1	−1.13
1437302_at	adrenergic receptor, beta 2	Adrb2	−1.13
1438183_x_at	sorbitol dehydrogenase 1	Sdh1	−1.13
1440491_at	solute carrier family 1 (glial high affinity glutamate transporter),	Slc1a3	−1.13
1448359_a_at	hypoxia induced gene 1	Hig1	−1.13
1451446_at	anthrax toxin receptor 1	Antxr1	−1.13
1451775_s_at	interleukin 13 receptor, alpha 1	Il13ra1	−1.13
1416855_at	growth arrest specific 1	Gas1	−1.14
1417566_at	abhydrolase domain containing 5	Abhd5	−1.14
1417639_at	solute carrier family 22 (organic cation transporter), member 4	Slc22a4	−1.14
1420915_at	signal transducer and activator of transcription 1	Stat1	−1.14
1422678_at	diacylglycerol O-acyltransferase 2	Dgat2	−1.14
1423824_at	RIKEN cDNA 5031439A09 gene	5031439A09Rik	−1.14
1426952_at	Rho GTPase activating protein 18	Arhgap18	−1.14
1433819_s_at	1-acylglycerol-3-phosphate O-acyltransferase 3	Agpat3	−1.14
1434486_x_at	UDP-glucose pyrophosphorylase 2	Ugp2	−1.14
1444479_at	Transcribed sequences	NA	−1.14
1447173_at	NA	NA	−1.14
1450618_a_at	small proline-rich protein 2A	Sprr2a	−1.14
1423062_at	insulin-like growth factor binding protein 3	Igfbp3	−1.15
1435842_at	RIKEN cDNA 1110038O08 gene	1110038O08Rik	−1.15
1437458_x_at	clusterin	Clu	−1.15
1437932_a_at	claudin 1	Cldn1	−1.15
1448312_at	proprotein convertase subtilisin/kexin type 2	Pcsk2	−1.15
1451690_a_at	poliovirus receptor-related 4	Pvrl4	−1.15
1453072_at	G protein-coupled receptor 160	Gpr160	−1.15
1456321_at	RIKEN cDNA 3830408G10 gene	3830408G10Rik	−1.15
1415943_at	syndecan 1	Sdc1	−1.16
1416481_s_at	hypoxia induced gene 1	Hig1	−1.16
1421217_a_at	lectin, galactose binding, soluble 9	Lgals9	−1.16
1421365_at	follistatin	Fst	−1.16
1423844_s_at	cystathionine beta-synthase	Cbs	−1.16
1437279_x_at	syndecan 1	Sdc1	−1.16
1439148_a_at	phosphofructokinase, liver, B-type	Pfkl	−1.16
1439847_s_at	Kruppel-like factor 12	Klf12	−1.16
1444274_at	Transcribed sequence with moderate similarity to protein pir: S12	NA	−1.16
1450976_at	N-myc downstream regulated gene 1	Ndrg1	−1.16
1451546_s_at	transmembrane protein 40	Tmem40	−1.16
1455872_at	hypothetical protein A030013D21	A030013D21	−1.16
1460236_at	kallikrein 10	Klk10	−1.16
1422941_at	wingless-related MMTV integration site 16	Wnt16	−1.17
1426604_at	ribonuclease L (2′,5′-oligoisoadenylate synthetase-dependent)	Rnasel	−1.17
1426911_at	desmocollin 2	Dsc2	−1.17
1431777_a_at	high mobility group nucleosomal binding domain 3	Hmgn3	−1.17
1433266_at	RIKEN cDNA 2810416A17 gene	2810416A17Rik	−1.17
1441971_at	Transcribed sequences	NA	−1.17
1451742_a_at	UDP-glucose pyrophosphorylase 2	Ugp2	−1.17
1452092_at	RIKEN cDNA 4631426J05 gene	4631426J05Rik	−1.17
1459009_at	Utrophin	Utrn	−1.17
1417143_at	endothelial differentiation, lysophosphatidic acid G-protein-coup	Edg2	−1.18
1438251_x_at	protease, serine, 11 (lgf binding)	Prss11	−1.18
1441242_at	Dipeptidylpeptidase 4	Dpp4	−1.18
1442348_at	2 days pregnant adult female oviduct cDNA, RlKEN full-length e	NA	−1.18
1445710_x_at	RIKEN cDNA 1110051B16 gene	1110051B16Rik	−1.18
1455915_at	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgala	Galnt4	−1.18
1416455_a_at	crystallin, alpha B	Cryab	−1.19
1418135_at	AF4/FMR2 family, member 1	Aff1	−1.19
1418497_at	fibroblast growth factor 13	Fgf13	−1.19
1420822_s_at	sphingosine-1-phosphate phosphatase 1	Sgpp1	−1.19
1425560_a_at	S100 calcium binding protein A16	S100a16	−1.19
1434059_at	RIKEN cDNA B230312A22 gene	B230312A22Rik	−1.19
1446480_at	Adult male corpora quadrigemina cDNA, RIKEN full-length enric	NA	−1.19
1415906_at	thymosin, beta 4, X chromosome	Tmsb4x	−1.20
1419663_at	osteoglycin	Ogn	−1.20
1421045_at	mannose receptor, C type 2	Mrc2	−1.20
1429582_at	BTB (POZ) domain containing 14A	Btbd14a	−1.20
1430114_at	RIKEN cDNA 5430420C16 gene	5430420C16Rik	−1.20
1435059_at	development and differentiation enhancing	Ddef1	−1.20
1435283_s_at	expressed sequence AI414343	Al414343	−1.20
1436994_a_at	histone 1, H1c	Hist1h1c	−1.20
1445421_at	Transcribed sequences	NA	−1.20
1447676_x_at	S100 calcium binding protein A16	S100a16	−1.20
1452138_a_at	angiotensin I converting enzyme (peptidyl-dipeptidase A) 2	Ace2	−1.20
1452388_at	heat shock protein 1A	Hspa1a	−1.20
1416101_a_at	histone 1, H1c	Hist1h1c	−1.21
1417795_at	cell adhesion molecule with homology to L1CAM	Chl1	−1.21
1419239_at	zinc finger protein 54	Zfp54	−1.21
1425284_a_at	RAB27A, member RAS oncogene family	Rab27a	−1.21
1437868_at	cDNA sequence BC023892	BC023892	−1.21
1439184_s_at	thioredoxin-like 5	Txnl5	−1.21
1443906_at	decay accelerating factor 1	Daf1	−1.21
1448499_a_at	epoxide hydrolase 2, cytoplasmic	Ephx2	−1.21
1458127_at	NA	NA	−1.21
1433971_at	calmodulin binding transcription activator 1	Camta1	−1.22
1439203_at	Special AT-rich sequence binding protein 1	Satb1	−1.22
1424359_at	5-oxoprolinase (ATP-hydrolysing)	Oplah	−1.23
1432418_a_at	creatine kinase, mitochondrial 1, ubiquitous	Ckmt1	−1.23
1434485_a_at	UDP-glucose pyrophosphorylase 2	Ugp2	−1.23
1447299_at	NA	NA	−1.23
1452160_at	TCDD-inducible poly(ADP-ribose) polymerase	Tiparp	−1.23
1416749_at	protease, serine, 11 (Igf binding)	Prss11	−1.24
1418073_at	acyl-CoA thioesterase 9	Acot9	−1.24
1427477_at	transmembrane protease, serine 13	Tmprss13	−1.24
1436183_at	RIKEN cDNA 9830115L13 gene	9830115L13Rik	−1.24
1436633_at	LOC380741 (LOC380741), mRNA	NA	−1.24
1437869_at	RIKEN cDNA 3222402P14 gene	3222402P14Rik	−1.24
1438115_a_at	solute carrier family 9 (sodium/hydrogen exchanger), isoform 3	Slc9a3r1	−1.24
1449773_s_at	growth arrest and DNA-damage-inducible 45 beta	Gadd45b	−1.24
1455372_at	cytoplasmic polyadenylation element binding protein 3	Cpeb3	−1.24
1456891_at	DENN/MADD domain containing 2C	Dennd2c	−1.24
1420821_at	sphingosine-1-phosphate phosphatase 1	Sgpp1	−1.25
1430567_at	serine protease inhibitor, Kazal type 5	Spink5	−1.25
1434575_at	erythrocyte protein band 4.1-like 1	Epb4.1l1	−1.25
1434738_at	threonyl-tRNA synthetase-like 2	Tarsl2	−1.25
1434802_s_at	neurotrophin 3	Ntf3	−1.25
1435354_at	potassium inwardly-rectifying channel, subfamily J, member 15	Kcnj15	−1.25
1437434_a_at	RIKEN cDNA 5031439A09 gene	5031439A09Rik	−1.25
1437469_at	RIKEN cDNA A030007D23 gene	A030007D23Rik	−1.25
1438588_at	pleiomorphic adenoma gene-like 1	Plagl1	−1.25
1449968_s_at	acyl-Coenzyme A thioesterase 2, mitochondrial	Acate2	−1.25
1453377_at	SH2 domain containing 4A	Sh2d4a	−1.25
1455786_at	RIKEN cDNA 2610036F08 gene	2610036F08Rik	−1.25
1456003_a_at	solute carrier family 1 (glutamate/neutral amino acid transporter)	Slc1a4	−1.25
1459823_at	EH-domain containing 2	Ehd2	−1.25
1416343_a_at	lysosomal membrane glycoprotein 2	Lamp2	−1.26
1418890_a_at	RAB3D, member RAS oncogene family	Rab3d	−1.26
1419133_at	envoplakin	Evpl	−1.26
1429637_at	RIKEN cDNA 2210419I08 gene	2210419I08Rik	−1.26
1436122_at	Zinc finger protein 667 (Zfp667), mRNA	A830025F02Rik	−1.26
1436293_x_at	DNA segment, Chr 1, ERATO Doi 471, expressed	D1Ertd471e	−1.26
1448233_at	prion protein	Prnp	−1.26
1451201_s_at	ribonuclease/angiogenin inhibitor 1	Rnh1	−1.26
1455304_at	Similar to Munc13-3 (LOC235480), mRNA	NA	−1.26
1460351_at	S100 calcium binding protein A11 (calizzarin)	S100a11	−1.26
1416921_x_at	aldolase 1, A isoform	Aldo1	−1.27
1417580_s_at	selenium binding protein 1	Selenbp1	−1.27
1424877_a_at	aminolevulinate, delta-, dehydratase	Alad	−1.27
1433481_at	FK506 binding protein 14	Fkbp14	−1.27
1434815_a_at	mitogen-activated protein kinase-activated protein kinase 3	Mapkapk3	−1.27
1437058_at	EGF-like-domain, multiple 3	Egfl3	−1.27
1438116_x_at	solute carrier family 9 (sodium/hydrogen exchanger), isoform 3	Slc9a3r1	−1.27
1443122_at	NA	NA	−1.27
1444441_at	Transcribed sequences	NA	−1.27
1451508_at	RIKEN cDNA 1700108L22 gene	1700108L22Rik	−1.27
1418267_at	macrophage stimulating 1 (hepatocyte growth factor-like)	Mst1	−1.28
1441793_at	Protein phosphatase 1, regulatory (inhibitor) subunit 11	Ppp1r11	−1.28
1448786_at	RIKEN cDNA 1100001H23 gene	1100001H23Rik	−1.28
1449131_s_at	CD1d1 antigen	Cd1d1	−1.28
1457358_at	Myeloid ecotropic viral integration site-related gene 1	Mrg1	−1.28
1416138_at	annexin A7	Anxa7	−1.29
1416194_at	cytochrome P450, family 4, subfamily b, polypeptide 1	Cyp4b1	−1.29
1422822_at	StAR-related lipid transfer (START) domain containing 5	Stard5	−1.29
1424096_at	keratin complex 2, basic, gene 5	Krt2-5	−1.29
1428922_at	RIKEN cDNA 1200009O22 gene	1200009O22Rik	−1.29
1437665_at	Putative cytokine receptor family II soluble 1 precursor (CRF2-s	Il22ra2	−1.29
1439375_x_at	aldolase 1, A isoform	Aldo1	−1.29
1448606_at	endothelial differentiation, lysophosphatidic acid G-protein-coup	Edg2	−1.29
1455521_at	Kruppel-like factor 12	Klf12	−1.29
1460407_at	Spi-B transcription factor (Spi-1/PU.1 related)	Spib	−1.29
1417335_at	sulfotransferase family, cytosolic, 2B, member 1	Sult2b1	−1.30
1423035_s_at	thioredoxin-like 5	Txnl5	−1.30
1427553_at	Clone IMAGE: 4190185, mRNA, partial cds	NA	−1.30
1438407_at	RIKEN cDNA 9330132E09 gene	9330132E09Rik	−1.30
1445701_at	ATPase, Ca++ transporting, plasma membrane 4 (Atp2b4), mR	Atp2b4	−1.30
1460657_at	wingless related MMTV integration site 10a	Wnt10a	−1.30
1416554_at	PDZ and LIM domain 1 (elfin)	Pdlim1	−1.31
1419401_at	ankyrin repeat and SOCS box-containing protein 13	Asb13	−1.31
1435435_at	cortactin binding protein 2	Cortbp2	−1.31
1437689_x_at	clusterin	Clu	−1.31
1448491_at	enoyl coenzyme A hydratase 1 peroxisomal	Ech1	−1.31
1449130_at	CD1d1 antigen	Cd1d1	−1.31
1452714_at	RIKEN cDNA 1200003E16 gene	1200003E16Rik	−1.31
1420191_s_at	DNA segment, Chr 16, Brigham & Women's Genetics 1494 expr	D16Bwg1494e	−1.32
1449036_at	ring finger protein 128	Rnf128	−1.32
1449770_x_at	DNA segment, Chr 16, Brigham & Women's Genetics 1494 expr	D16Bwg1494e	−1.32
1451177_at	DnaJ (Hsp40) homolog, subfamily B, member 4	Dnajb4	−1.32
1425248_a_at	TYRO3 protein tyrosine kinase 3	Tyro3	−1.33
1447992_s_at	proprotein convertase subtilisin/kexin type 2	Pcsk2	−1.33
1452246_at	osteoclast stimulating factor 1	Ostf1	−1.33
1459749_s_at	FAT tumor suppressor homolog 4 (Drosophila)	Fat4	−1.33
1416805_at	RIKEN cDNA 1110032E23 gene	1110032E23Rik	−1.34
1418951_at	taxilin beta	Txlnb	−1.34
1420565_at	homeo box A1	Hoxa1	−1.34
1426721_s_at	TCDD-inducible poly(ADP-ribose) polymerase	Tiparp	−1.34
1430396_at	RIKEN cDNA 5730403I07 gene	5730403I07Rik	−1.34
1433582_at	RIKEN cDNA 1190002N15 gene	1190002N15Rik	−1.34
1439860_at	eukaryotic elongation factor-2 kinase	Eef2k	−1.34
1441774_at	Rab38, member of RAS oncogene family	Rab38	−1.34
1445574_at	Transcribed sequences	NA	−1.34
1450726_at	N-acylsphingosine amidohydrolase 2	Asah2	−1.34
1455101_at	Clone IMAGE: 2647821, mRNA	NA	−1.34
1457533_at	Transcribed sequences	NA	−1.34
1417738_at	RAB25, member RAS oncogene family	Rab25	−1.35
1420583_a_at	RAR-related orphan receptor alpha	Rora	−1.35
1423135_at	thymus cell antigen 1, theta	Thy1	−1.35
1427228_at	RIKEN cDNA 2410003B16 gene	2410003B16Rik	−1.35
1431057_a_at	protease, serine, 23	Prss23	−1.35
1438057_at	Transcribed sequence with moderate similarity to protein pdb: 1L	NA	−1.35
1439429_x_at	deltex 2 homolog (Drosophila)	Dtx2	−1.35
1442074_at	Transcribed sequences	NA	−1.35
1442791_x_at	RIKEN cDNA 6720407P12 gene	6720407P12Rik	−1.35
1445558_at	NA	NA	−1.35
1450724_at	down-regulated by Ctnnb1, a	Drctnnb1a	−1.35
1415944_at	syndecan 1	Sdc1	−1.36
1419738_a_at	tropomyosin 2, beta	Tpm2	−1.36
1422631_at	aryl-hydrocarbon receptor	Ahr	−1.36
1422637_at	Ras association (RalGDS/AF-6) domain family 5	Rassf5	−1.36
1422638_s_at	Ras association (RalGDS/AF-6) domain family 5	Rassf5	−1.36
1425658_at	CD109 antigen	Cd109	−1.36
1426276_at	interferon induced with helicase C domain 1	Ifih1	−1.36
1432739_at	RIKEN cDNA 2900060K15 gene	2900060K15Rik	−1.36
1434799_x_at	aldolase 1, A isoform	Aldo1	−1.36
1436475_at	nuclear receptor subfamily 2, group F, member 2	Nr2f2	−1.36
1458706_at	Transcribed sequences	NA	−1.36
1452411_at	leucine rich repeat containing 1	Lrrc1	−1.37
1417823_at	glycine C-acetyltransferase (2-amino-3-ketobutyrate-coenzyme	Gcat	−1.38
1418601_at	aldehyde dehydrogenase family 1, subfamily A7	Aldh1a7	−1.38
1422667_at	keratin complex 1, acidic, gene 15	Krt1-15	−1.38
1425002_at	cDNA sequence BC010462	BC010462	−1.38
1433604_x_at	aldolase 1, A isoform	Aldo1	−1.38
1442560_at	Monoglyceride lipase	Mgll	−1.38
1455091_at	male-specific lethal-2 homolog (Drosophila)	Msl2	−1.38
1418799_a_at	procollagen, type XVII, alpha 1	Col17a1	−1.39
1419091_a_at	annexin A2	Anxa2	−1.39
1433581_at	RIKEN cDNA 1190002N15 gene	1190002N15Rik	−1.39
1435342_at	potassium inwardly-rectifying channel, subfamily K, member 6	Kcnk6	−1.39
1449459_s_at	ankyrin repeat and SOCS box-containing protein 13	Asb13	−1.39
1456317_at	RIKEN cDNA 1700055N04 gene	1700055N04Rik	−1.39
1459301_at	Myeloid ecotropic viral integration site-related gene 1	Mrg1	−1.39
1460459_at	progestin and adipoQ receptor family member V	Paqr5	−1.39
1427318_s_at	dysferlin /// fer-1-like 3, myoferlin (C. elegans)	Dysf /// Fer1l3	−1.40
1458055_at	Desmocollin 3	Dsc3	−1.40
1418925_at	cadherin EGF LAG seven-pass G-type receptor 1	Celsr1	−1.41
1422662_at	lectin, galactose binding, soluble 8	Lgals8	−1.41
1423034_at	thioredoxin-like 5	Txnl5	−1.41
1426941_at	mucin 15	Muc15	−1.41
1448792_a_at	cytochrome P450, family 2, subfamily f, polypeptide 2	Cyp2f2	−1.41
1425801_x_at	coactosin-like 1 (Dictyostelium)	Cotl1	−1.42
1436733_at	RIKEN cDNA E130309F12 gene	E130309F12Rik	−1.42
1437258_at	Small proline-rich protein 2B	Sprr2a	−1.42
1448612_at	stratifin	Sfn	−1.42
1449013_at	eukaryotic elongation factor-2 kinase	Eef2k	−1.42
1449259_at	RAB3D, member RAS oncogene family	Rab3d	−1.42
1428083_at	RIKEN cDNA 2310043N10 gene	2310043N10Rik	−1.43
1429779_at	eukaryotic translation initiation factor 2C, 4	Eif2c4	−1.43
1435551_at	formin-family protein FHOS2	FHOS2	−1.43
1437927_at	discs, large homolog 2 (Drosophila)	Dlgh2	−1.43
1443749_x_at	solute carrier family 1 (glial high affinity glutamate transporter),	Slc1a3	−1.43
1450699_at	selenium binding protein 1	Selenbp1	−1.43
1418944_at	cysteinyl leukotriene receptor 1	Cysltr1	−1.44
1427165_at	interleukin 13 receptor, alpha 1	Il13ra1	−1.44
1427183_at	epidermal growth factor-containing fibulin-like extracellular matri	Efemp1	−1.44
1428891_at	RIKEN cDNA 9130213B05 gene	9130213B05Rik	−1.44
1437303_at	interleukin 6 signal transducer	Il6st	−1.44
1451413_at	calpastatin	Cast	−1.44
1457413_at	Receptor tyrosine kinase-like orphan receptor 1	Ror1	−1.44
1418091_at	transcription factor CP2-like 1	Tcfcp2l1	−1.45
1422603_at	ribonuclease, RNase A family 4	Rnase4	−1.45
1424214_at	RIKEN cDNA 9130213B05 gene	9130213B05Rik	−1.45
1427912_at	carbonyl reductase 3	Cbr3	−1.45
1428145_at	acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-	Acaa2	−1.45
1435972_at	calpastatin	Cast	−1.45
1436092_at	Transcribed sequence with weak similarity to protein pir: S5832	NA	−1.45
1460732_a_at	periplakin	Ppl	−1.45
1418762_at	decay accelerating factor 1	Daf1	−1.46
1419086_at	fibroblast growth factor binding protein 1	Fgfbp1	−1.46
1425028_a_at	tropomyosin 2, beta	Tpm2	−1.46
1430843_at	glutamate decarboxylase-like 1	Gadl1	−1.46
1434051_s_at	heat shock 70 kDa protein 12A	Hspa12a	−1.46
1439153_at	IBR domain containing 2	Ibrdc2	−1.46
1436932_at	transcription factor CP2-like 4	Tfcp2l4	−1.47
1448213_at	annexin A1	Anxa1	−1.47
1421492_at	prostaglandin D2 synthase 2, hematopoietic	Ptgds2	−1.48
1423771_at	protein kinase C, delta binding protein	Prkcdbp	−1.48
1433610_at	expressed sequence AA986860	AA986860	−1.48
1416531_at	glutathione S-transferase omega 1	Gsto1	−1.49
1417962_s_at	growth hormone receptor	Ghr	−1.49
1419027_s_at	glycolipid transfer protein	Gltp	−1.49
1428146_s_at	acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-	Acaa2	−1.49
1450971_at	growth arrest and DNA-damage-inducible 45 beta	Gadd45b	−1.49
1452059_at	solute carrier family 35, member F5	Slc35f5	−1.49
1453289_at	eukaryotic translation initiation factor 2C, 4	Eif2c4	−1.49
1457044_at	RIKEN cDNA 4732474O15 gene	4732474O15Rik	−1.49
1422906_at	ATP-binding cassette, sub-family G (WHITE), member 2	Abcg2	−1.50
1431248_at	RIKEN cDNA 5031426D15 gene	5031426D15Rik	−1.50
1437312_at	bone morphogenetic protein receptor, type 1B	Bmpr1b	−1.50
1448494_at	growth arrest specific 1	Gas1	−1.50
1449577_x_at	tropomyosin 2, beta	Tpm2	−1.50
1451385_at	RIKEN cDNA 2310056P07 gene	2310056P07Rik	−1.50
1421456_at	purinergic receptor P2Y, G-protein coupled 1	P2ry1	−1.51
1423606_at	periostin, osteoblast specific factor	Postn	−1.51
1424239_at	RIKEN cDNA 2310066E14 gene	2310066E14Rik	−1.51
1444740_at	Transcribed sequences	NA	−1.51
1453286_at	plexin A2	Plxna2	−1.51
1419201_at	RIKEN cDNA 2310015I08 gene	2310015I08Rik	−1.52
1424612_at	NIPA-like domain containing 2	Npal2	−1.52
1425506_at	myosin, light polypeptide kinase	Mylk	−1.52
1436365_at	zinc finger and BTB domain containing 36	Zbtb36	−1.52
1436702_at	cDNA sequence BC034068	BC034068	−1.52
1438125_at	RIKEN cDNA C230085N15 gene	C230085N15Rik	−1.52
1454783_at	interleukin 13 receptor, alpha 1	Il13ra1	−1.52
1440635_at	Transcribed sequences	NA	−1.53
1455238_at	melanoma associated antigen (mutated) 1-like 1	Mum1l1	−1.53
1426221_at	loss of heterozygosity, 11, chromosomal region 2, gene A homo	Loh11cr2a	−1.54
1429274_at	RIKEN cDNA 2310010M24 gene	2310010M24Rik	−1.54
1433719_at	solute carrier family 9 (sodium/hydrogen exchanger), isoform 9	Slc9a9	−1.54
1451739_at	Kruppel-like factor 5	Klf5	−1.54
1435973_at	Transcribed sequences	NA	−1.55
1450633_at	calmodulin 4	Calm4	−1.55
1452843_at	interleukin 6 signal transducer	Il6st	−1.55
1441342_at	dipeptidylpeptidase 4	Dpp4	−1.56
1456036_x_at	glutathione S-transferase omega 1	Gsto1	−1.56
1428680_at	CDP-diacylglycerol synthase 1	Cds1	−1.57
1435785_at	EH-domain containing 2	Ehd2	−1.57
1450769_s_at	StAR-related lipid transfer (START) domain containing 5	Stard5	−1.57
1455140_at	expressed sequence AI848332	AI848332	−1.57
1424130_a_at	polymerase I and transcript release factor	Ptrf	−1.59
1444937_at	NA	NA	−1.59
1450391_a_at	monoglyceride lipase	Mgll	−1.59
1450435_at	L1 cell adhesion molecule	L1cam	−1.59
1421844_at	interleukin 1 receptor accessory protein	Il1rap	−1.60
1424842_a_at	Rho GTPase activating protein 24	Arhgap24	−1.60
1426245_s_at	microtubule-associated protein, RP/EB family, member 2	Mapre2	−1.60
1426397_at	transforming growth factor, beta receptor II	Tgfbr2	−1.60
1442920_at	Kruppel-like factor 3 (basic)	Klf3	−1.60
1427011_a_at	LanC (bacterial lantibiotic synthetase component C)-like 1	Lancl1	−1.61
1434957_at	cell adhesion molecule-related/down-regulated by oncogenes	Cdon	−1.61
1416527_at	RAB32, member RAS oncogene family	Rab32	−1.62
1416589_at	secreted acidic cysteine rich glycoprotein	Sparc	−1.62
1421690_s_at	agouti related protein	Agrp	−1.62
1431110_at	RIKEN cDNA 5430431D22 gene	5430431D22Rik	−1.62
1434866_x_at	carnitine palmitoyltransferase 1a, liver	Cpt1a	−1.62
1450981_at	calponin 2	Cnn2	−1.62
1416002_x_at	coactosin-like 1 (Dictyostelium)	Cotl1	−1.63
1439628_x_at	Rab38, member of RAS oncogene family	Rab38	−1.63
1451451_at	grancalcin	Gca	−1.63
1452614_at	hypothetical gene supported by AF014453	LOC229672	−1.63
1419051_at	OVO homolog-like 1 (Drosophila)	Ovol1	−1.64
1422573_at	AMP deaminase 3	Ampd3	−1.64
1427012_at	LanC (bacterial lantibiotic synthetase component C)-like 1	Lancl1	−1.64
1444147_at	proprotein convertase subtilisin/kexin type 2	Pcsk2	−1.64
1456084_x_at	fibromodulin	Fmod	−1.64
1460406_at	expressed sequence AI427122	AI427122	−1.64
1416007_at	special AT-rich sequence binding protein 1	Satb1	−1.65
1449586_at	plakophilin 1	Pkp1	−1.65
1449848_at	guanine nucleotide binding protein, alpha 14	Gna14	−1.65
1454867_at	meningioma 1	Mn1	−1.65
1428650_at	tensin 1	Tns1	−1.66
1437231_at	SLIT and NTRK-like family, member 6	Slitrk6	−1.66
1438156_x_at	carnitine palmitoyltransferase 1a, liver	Cpt1a	−1.66
1451989_a_at	microtubule-associated protein, RP/EB family, member 2	Mapre2	−1.66
1455037_at	plexin A2	Plxna2	−1.66
1459529_at	RIKEN cDNA E230016K23 gene	E230016K23Rik	−1.66
1418318_at	ring finger protein 128	Rnf128	−1.67
1420461_at	macrophage stimulating 1 receptor (c-met-related tyrosine kinas	Mst1r	−1.67
1435693_at	mal, T-cell differentiation protein-like	Mall	−1.67
1456114_at	CDP-diacylglycerol synthase 1	Cds1	−1.67
1424034_at	RAR-related orphan receptor alpha	Rora	−1.68
1427164_at	interleukin 13 receptor, alpha 1	Il13ra1	−1.68
1433509_s_at	DNA segment, Chr 6, ERATO Doi 253, expressed	D6Ertd253e	−1.68
1441214_at	exophilin 5	Exph5	−1.68
1455061_a_at	acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-	Acaa2	−1.68
1417394_at	Kruppel-like factor 4 (gut)	Klf4	−1.69
1437829_s_at	eukaryotic elongation factor-2 kinase	Eef2k	−1.69
1450005_x_at	EGF-like-domain, multiple 9	Egfl9	−1.69
1455627_at	procollagen, type VIII, alpha 1	Col8a1	−1.69
1421970_a_at	glutamate receptor, ionotropic, AMPA2 (alpha 2)	Gria2	−1.70
1434146_at	Glutamate receptor, ionotropic, AMPA2 (alpha 2) (Gria2), mRNA	Gria2	−1.70
1436236_x_at	coactosin-like 1 (Dictyostelium)	Cotl1	−1.70
1427537_at	epiplakin 1	Eppk1	−1.71
1424638_at	cyclin-dependent kinase inhibitor 1A (P21)	Cdkn1a	−1.72
1439675_at	RIKEN cDNA 4933429D07 gene	4933429D07Rik	−1.72
1453345_at	RIKEN cDNA 3830408G10 gene	3830408G10Rik	−1.72
1416592_at	glutaredoxin 1 (thioltransferase)	Glrx1	−1.73
1436119_at	aldehyde dehydrogenase 1 family, member L2	Aldh1l2	−1.73
1436182_at	special AT-rich sequence binding protein 1	Satb1	−1.73
1420760_s_at	N-myc downstream regulated-like	Ndrl	−1.75
1434773_a_at	solute carrier family 2 (facilitated glucose transporter), member 1	Slc2a1	−1.75
1436590_at	protein phosphatase 1, regulatory (inhibitor) subunit 3B	Ppp1r3b	−1.75
1445626_at	Lectin, galactose binding, soluble 3	Lgals3	−1.75
1456741_s_at	glycoprotein m6a	Gpm6a	−1.75
1416200_at	RIKEN cDNA 9230117N10 gene	9230117N10Rik	−1.76
1427019_at	protein tyrosine phosphatase, receptor type Z, polypeptide 1	Ptprz1	−1.76
1442434_at	DNA segment, Chr 8, ERATO Doi 82, expressed	D8Ertd82e	−1.76
1418891_a_at	RAB3D, member RAS oncogene family	Rab3d	−1.77
1439449_at	special AT-rich sequence binding protein 1	Satb1	−1.77
1455377_at	RIKEN cDNA 4921517B04 gene /// similar to FLJ23033 protein	17B04Rik /// LOC38	−1.77
1418086_at	protein phosphatase 1, regulatory (inhibitor) subunit 14A	Ppp1r14a	−1.78
1424701_at	protocadherin 20	Pcdh20	−1.78
1448392_at	secreted acidic cysteine rich glycoprotein	Sparc	−1.78
1455288_at	RIKEN cDNA 1110036O03 gene	1110036O03Rik	−1.78
1457656_s_at	RIKEN cDNA C230085N15 gene	C230085N15Rik	−1.78
1426600_at	solute carrier family 2 (facilitated glucose transporter), member 1	Slc2a1	−1.79
1443284_at	Special AT-rich sequence binding protein 1	Satb1	−1.79
1422308_a_at	lectin, galactose binding, soluble 7	Lgals7	−1.80
1424698_s_at	grancalcin	Gca	−1.80
1432976_at	RIKEN cDNA 2310038E17 gene	2310038E17Rik	−1.80
1460003_at	expressed sequence AI956758	AI956758	−1.81
1425213_at	RIKEN cDNA 6430514L14 gene	6430514L14Rik	−1.82
1458738_at	Guanine nucleotide binding protein, alpha 14	Gna14	−1.82
1439794_at	Netrin 4 (Ntn4), mRNA	Ntn4	−1.83
1444392_at	Leprecan-like 1	Leprel1	−1.83
1421679_a_at	cyclin-dependent kinase inhibitor 1A (P21)	Cdkn1a	−1.84
1429808_at	RIKEN cDNA 1110020C03 gene	1110020C03Rik	−1.84
1417700_at	Rab38, member of RAS oncogene family	Rab38	−1.85
1420468_at	ankyrin repeat and SOCS box-containing protein 17	Asb17	−1.85
1426599_a_at	solute carrier family 2 (facilitated glucose transporter), member 1	Slc2a1	−1.85
1420807_a_at	EGF-like-domain, multiple 9	Egfl9	−1.86
1426243_at	cystathionase (cystathionine gamma-lyase)	Cth	−1.86
1437813_at	absent in melanoma 1-like	Aim1l	−1.86
1450782_at	wingless-related MMTV integration site 4	Wnt4	−1.86
1460463_at	RIKEN cDNA 4632413I24 gene	4632413I24Rik	−1.86
1420312_s_at	NA	NA	−1.87
1441687_at	wingless-related MMTV integration site 4	Wnt4	−1.87
1417089_a_at	creatine kinase, mitochondrial 1, ubiquitous	Ckmt1	−1.88
1449994_at	epithelial mitogen	Epgn	−1.88
1431775_at	RIKEN cDNA 3100002H09 gene	3100002H09Rik	−1.89
1452284_at	protein tyrosine phosphatase, receptor type Z, polypeptide 1	Ptprz1	−1.89
1455165_at	RAR-related orphan receptor alpha, mRNA (cDNA clone MGC: 5	Rora	−1.89
1418912_at	plexin domain containing 2	Plxdc2	−1.90
1441917_s_at	transmembrane protein 40	Tmem40	−1.90
1449158_at	potassium channel, subfamily K, member 2	Kcnk2	−1.90
1419204_at	delta-like 1 (Drosophila)	Dll1	−1.91
1428622_at	DEP domain containing 6	Depdc6	−1.91
1437019_at	RIKEN cDNA 2200001I15 gene	2200001I15Rik	−1.91
1445638_at	Myeloid ecotropic viral integration site-related gene 1	Mrg1	−1.91
1449816_at	sulfotransferase family 5A, member 1	Sult5a1	−1.91
1429067_at	calpain, small subunit 2	Capns2	−1.92
1438570_at	Transcribed sequences	NA	−1.92
1456174_x_at	N-myc downstream regulated gene 1	Ndrg1	−1.92
1416022_at	fatty acid binding protein 5, epidermal	Fabp5	−1.93
1417129_a_at	myeloid ecotropic viral integration site-related gene 1	Mrg1	−1.94
1433203_at	RIKEN cDNA 6030400A10 gene	6030400A10Rik	−1.94
1435595_at	RIKEN cDNA 1810011O10 gene	1810011O10Rik	−1.94
1455200_at	p21 (CDKN1A)-activated kinase 6	Pak6	−1.94
1417185_at	lymphocyte antigen 6 complex, locus A	Ly6a	−1.95
1417346_at	PYD and CARD domain containing	Pycard	−1.95
1430550_at	lipase-like, ab-hydrolase domain containing 3	Lipl3	−1.95
1436325_at	RAR-related orphan receptor alpha	Rora	−1.95
1448987_at	acetyl-Coenzyme A dehydrogenase, long-chain	Acadl	−1.95
1455408_at	RIKEN cDNA 4732472I07 gene	4732472I07Rik	−1.95
1455794_at	RIKEN cDNA D130058I21 gene	D130058I21Rik	−1.95
1460038_at	POU domain, class 3, transcription factor 1	Pou3f1	−1.95
1418084_at	neuropilin 1	Nrp1	−1.98
1447791_s_at	guanine nucleotide binding protein, alpha 14	Gna14	−1.98
1440842_at	RIKEN cDNA C230085N15 gene	C230085N15Rik	−1.99
1442936_at	NA	NA	−1.99
1451021_a_at	Kruppel-like factor 5	Klf5	−2.00
1416318_at	serine (or cysteine) proteinase inhibitor, clade B, member 1a	Serpinb1a	−2.01
1440091_at	myeloid ecotropic viral integration site-related gene 1	Mrg1	−2.02
1419905_s_at	hydroxyprostaglandin dehydrogenase 15 (NAD)	Hpgd	−2.05
1426785_s_at	monoglyceride lipase	Mgll	−2.05
1434425_at	expressed sequence AI597080	AI597080	−2.05
1436178_at	leprecan-like 1	Leprel1	−2.05
1437699_at	RIKEN cDNA E430014B02 gene	E430014B02Rik	−2.05
1439819_at	expressed sequence AU015263	AU015263	−2.05
1452031_at	solute carrier family 1 (glial high affinity glutamate transporter),	Slc1a3	−2.05
1421964_at	Notch gene homolog 3 (Drosophila)	Notch3	−2.06
1433768_at	RIKEN cDNA 2410003B16 gene	2410003B16Rik	−2.06
1434025_at	Kruppel-like factor 5	Klf5	−2.06
1424852_at	myocyte enhancer factor 2C	Mef2c	−2.07
1452232_at	UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgala	Galnt7	−2.07
1417214_at	RAB27b, member RAS oncogene family	Rab27b	−2.08
1418365_at	cathepsin H	Ctsh	−2.08
1424976_at	ras homolog gene family, member V	Rhov	−2.08
1451308_at	elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3	Elovl4	−2.08
1451415_at	RIKEN cDNA 1810011O10 gene	1810011O10Rik	−2.08
1447861_x_at	myeloid ecotropic viral integration site-related gene 1	Mrg1	−2.09
1448943_at	neuropilin 1	Nrp1	−2.09
1424208_at	prostaglandin E receptor 4 (subtype EP4)	Ptger4	−2.11
1455186_a_at	RIKEN cDNA 1190003J15 gene	1190003J15Rik	−2.11
1436838_x_at	coactosin-like 1 (Dictyostelium)	Cotl1	−2.12
1415897_a_at	microsomal glutathione S-transferase 1	Mgst1	−2.13
1437811_x_at	Coactosin-like 1 (Dictyostelium)	Cotl1	−2.13
1448873_at	occludin	Ocln	−2.14
1449938_at	placental protein 11 related	Pp11r	−2.16
1424966_at	transmembrane protein 40	Tmem40	−2.17
1426340_at	solute carrier family 1 (glial high affinity glutamate transporter), n	Slc1a3	−2.17
1443579_s_at	DEP domain containing 6	Depdc6	−2.17
1454666_at	Kruppel-like factor 3 (basic)	Klf3	−2.17
1439915_at	Myeloid ecotropic viral integration site-related gene 1	Mrg1	−2.18
1455573_at	keratin complex 1, acidic, gene 14	Krt1-14	−2.18
1459713_s_at	transmembrane protein 16A	Tmem16a	−2.18
1419082_at	serine (or cysteine) proteinase inhibitor, clade B, member 2	Serpinb2	−2.19
1437232_at	bactericidal/permeability-increasing protein-like 2	Bpil2	−2.20
1443814_x_at	cathepsin H	Ctsh	−2.20
1450643_s_at	acyl-CoA synthetase long-chain family member 1	Acsl1	−2.20
1417429_at	flavin containing monooxygenase 1	Fmo1	−2.21
1439492_at	RIKEN cDNA C130053K05 gene	C130053K05Rik	−2.21
1446764_at	Wingless-related MMTV integration site 3A	Wnt3a	−2.21
1451348_at	DEP domain containing 6	Depdc6	−2.21
1456815_at	forkhead box N1	Foxn1	−2.21
1426914_at	MARVEL (membrane-associating) domain containing 2	Mrvldc2	−2.22
1429503_at	RIKEN cDNA 2900024C23 gene	2900024C23Rik	−2.22
1420385_at	guanine nucleotide binding protein, alpha 14	Gna14	−2.23
1429123_at	RAB27A, member RAS oncogene family	Rab27a	−2.23
1450744_at	elongation factor RNA polymerase II 2	EII2	−2.23
1418649_at	EGL nine homolog 3 (C. elegans)	Egln3	−2.24
1439610_at	RAB27b, member RAS oncogene family	Rab27b	−2.24
1443138_at	Sulfotransferase family 5A, member 1	Sult5a1	−2.24
1448852_at	regucalcin	Rgn	−2.24
1417942_at	Ly6/Plaur domain containing 3	Lypd3	−2.25
1431786_s_at	RIKEN cDNA 1190003J15 gene	1190003J15Rik	−2.25
1419215_at	aldehyde oxidase 4	Aox4	−2.26
1435076_at	RIKEN cDNA 2310047D13 gene	2310047D13Rik	−2.26
1434369_a_at	crystallin, alpha B	Cryab	−2.27
1419709_at	stefin A3	Stfa3	−2.28
1420944_at	zinc finger protein 185	Zfp185	−2.29
1460302_at	thrombospondin 1	Thbs1	−2.29
1448944_at	neuropilin 1	Nrp1	−2.31
1451716_at	v-maf musculoaponeurotic fibrosarcoma oncogene family, protei	Mafb	−2.31
1452114_s_at	insulin-like growth factor binding protein 5	Igfbp5	−2.31
1423856_at	popeye domain containing 3	Popdc3	−2.33
1434272_at	cytoplasmic polyadenylation element binding protein 2	Cpeb2	−2.33
1430551_s_at	lipase-like, ab-hydrolase domain containing 3	Lipl3	−2.34
1419591_at	melanoma-derived leucine zipper, extra-nuclear factor	Mlze	−2.36
1421811_at	thrombospondin 1	Thbs1	−2.37
1434411_at	expressed sequence AW743884	AW743884	−2.37
1457632_s_at	myeloid ecotropic viral integration site-related gene 1	Mrg1	−2.38
1425103_at	angiotensin I converting enzyme (peptidyl-dipeptidase A) 2	Ace2	−2.41
1435639_at	RIKEN cDNA 2610528A11 gene	2610528A11Rik	−2.42
1451798_at	interleukin 1 receptor antagonist	Il1rn	−2.42
1439630_x_at	suprabasin	Sbsn	−2.44
1420364_at	G protein-coupled receptor 87	Gpr87	−2.45
1437463_x_at	transforming growth factor, beta induced	Tgfbi	−2.45
1437517_x_at	serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), me	Serpinb3a	−2.45
1449064_at	L-threonine dehydrogenase	Tdh	−2.45
1421604_a_at	Kruppel-like factor 3 (basic)	Klf3	−2.46
1434150_a_at	RIKEN cDNA 3300001H21 gene	3300001H21Rik	−2.46
1437876_at	Hypothetical gene supported by BC030430 (LOC382098), mRN	NA	−2.48
1449937_at	placental protein 11 related	Pp11r	−2.48
1451006_at	xanthine dehydrogenase	Xdh	−2.48
1453239_a_at	ankyrin repeat domain 22	Ankrd22	−2.48
1416697_at	dipeptidylpeptidase 4	Dpp4	−2.49
1422588_at	keratin complex 2, basic, gene 6b	Krt2-6b	−2.49
1429360_at	Kruppel-like factor 3 (basic)	Klf3	−2.49
1442067_at	Receptor tyrosine kinase-like orphan receptor 1	Ror1	−2.49
1448123_s_at	transforming growth factor, beta induced	Tgfbi	−2.49
1452766_at	RIKEN cDNA 2900041A09 gene	2900041A09Rik	−2.51
1415871_at	transforming growth factor, beta induced	Tgfbi	−2.52
1423883_at	acyl-CoA synthetase long-chain family member 1	Acsl1	−2.52
1425789_s_at	annexin A8	Anxa8	−2.52
1429313_at	receptor tyrosine kinase-like orphan receptor 1	Ror1	−2.52
1424356_a_at	meteorin, glial cell differentiation regulator-like	Metrnl	−2.54
1443017_at	cytoplasmic polyadenylation element binding protein 2	Cpeb2	−2.54
1446834_at	Cathepsin C	Ctsc	−2.54
1421965_s_at	Notch gene homolog 3 (Drosophila)	Notch3	−2.56
1459897_a_at	suprabasin	Sbsn	−2.56
1421040_a_at	glutathione S-transferase, alpha 2 (Yc2)	Gsta2	−2.57
1421308_at	carbonic anhydrase 13	Car13	−2.59
1460330_at	annexin A3	Anxa3	−2.59
1434295_at	RAS guanyl releasing protein 1	Rasgrp1	−2.61
1454858_x_at	RIKEN cDNA 3300001H21 gene	3300001H21Rik	−2.62
1420955_at	visinin-like 1	Vsnl1	−2.65
1427957_at	RIKEN cDNA 9530008L14 gene	9530008L14Rik	−2.65
1456250_x_at	transforming growth factor, beta induced	Tgfbi	−2.66
1429076_a_at	glycerophosphodiester phosphodiesterase domain containing 2	Gdpd2	−2.68
1423414_at	prostaglandin-endoperoxide synthase 1	Ptgs1	−2.69
1416382_at	cathepsin C	Ctsc	−2.70
1441094_at	alcohol dehydrogenase 6B (class V)	Adh6b	−2.70
1452166_a_at	keratin complex 1, acidic, gene 10	Krt1-10	−2.73
1426208_x_at	pleiomorphic adenoma gene-like 1	Plagl1	−2.74
1443926_at	Myeloid ecotropic viral integration site-related gene 1	Mrg1	−2.74
1454159_a_at	insulin-like growth factor binding protein 2	Igfbp2	−2.74
1423323_at	tumor-associated calcium signal transducer 2	Tacstd2	−2.76
1417852_x_at	chloride channel calcium activated 1	Clca1	−2.79
1459973_x_at	dipeptidylpeptidase 4	Dpp4	−2.80
1460591_at	estrogen receptor 1 (alpha)	Esr1	−2.80
1438109_at	chloride channel calcium activated 5	Clca5	−2.81
1447891_at	NA	NA	−2.81
1434151_at	RIKEN cDNA 3300001H21 gene	3300001H21Rik	−2.82
1417702_a_at	histamine N-methyltransferase	Hnmt	−2.83
1419492_s_at	defensin beta 1	Defb1	−2.83
1421307_at	carbonic anhydrase 13	Car13	−2.83
1435761_at	stefin A3	Stfa3	−2.83
1425102_a_at	angiotensin I converting enzyme (peptidyl-dipeptidase A) 2	Ace2	−2.87
1439528_at	RIKEN cDNA 4833423E24 gene	4833423E24Rik	−2.88
1426708_at	anthrax toxin receptor 2	Antxr2	−2.92
1435436_at	Transcribed sequences	NA	−2.92
1416225_at	alcohol dehydrogenase 1 (class I)	Adh1	−2.93
1450460_at	aquaporin 3	Aqp3	−2.95
1449500_at	serine (or cysteine) proteinase inhibitor, clade B, member 7	Serpinb7	−2.96
1424968_at	RIKEN cDNA 2210023G05 gene	2210023G05Rik	−2.99
1431211_s_at	thioesterase superfamily member 5	Them5	−2.99
1456539_at	Transcribed sequence with strong similarity to protein sp: P0072	NA	−3.02
1422587_at	transmembrane protein 45a	Tmem45a	−3.09
1419491_at	defensin beta 1	Defb1	−3.12
1438474_at	ankyrin repeat domain 35	Ankrd35	−3.12
1434227_at	keratinocyte differentiation associated protein	Krtdap	−3.16
1436520_at	expressed sequence AI450948	AI450948	−3.18
1441909_s_at	RIKEN cDNA 9530066K23 gene	9530066K23Rik	−3.20
1417853_at	chloride channel calcium activated 1	Clca1	−3.26
1459898_at	suprabasin	Sbsn	−3.31
1441341_at	Transcribed sequences	NA	−3.32
1437939_s_at	Cathepsin C	Ctsc	−3.34
1424713_at	calmodulin-like 4	Calml4	−3.36
1422008_a_at	aquaporin 3	Aqp3	−3.38
1435760_at	cystatin A	MGI: 3524930	−3.43
1448932_at	keratin complex 1, acidic, gene 16	Krt1-16	−3.44
1417732_at	annexin A8	Anxa8	−3.45
1457025_at	RIKEN cDNA 4833413O15 gene	4833413O15Rik	−3.46
1440523_at	retinal short chain dehydrogenase reductase	Rdhe2	−3.53
1441384_at	Transcribed sequences	NA	−3.55
1417408_at	coagulation factor III	F3	−3.63
1448152_at	insulin-like growth factor 2	Igf2	−3.64
1458000_at	desmoglein 1 alpha	Dsg1a	−3.70
1426808_at	lectin, galactose binding, soluble 3	Lgals3	−3.74
1416930_at	lymphocyte antigen 6 complex, locus D	Ly6d	−3.80
1419463_at	chloride channel calcium activated 2	Clca2	−3.86
1455519_at	desmoglein 1 alpha	Dsg1a	−3.90
1460259_s_at	chloride channel calcium activated 1	Clca1	−3.92
1439620_at	carbonic anhydrase 13	Car13	−3.93
1422481_at	keratin complex 2, basic, gene 1	Krt2-1	−4.06
1456203_at	RIKEN cDNA 1110020A10 gene	1110020A10Rik	−4.35
1424306_at	elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3	Elovl4	−4.40
1439183_at	N-acylsphingosine amidohydrolase (alkaline ceramidase) 3	Asah3	−4.57
1424265_at	N-acetylneuraminate pyruvate lyase	Npl	−4.60
1453801_at	thioesterase superfamily member 5	Them5	−4.68
1437578_at	chloride channel calcium activated 2	Clca2	−4.86
1429297_at	serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), me	Serpinb12	−4.97
1422939_at	serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), me	Serpinb3b	−5.05
1422940_x_at	serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), me	Serpinb3b	−5.07
1436448_a_at	prostaglandin-endoperoxide synthase 1	Ptgs1	−5.11
indicates data missing or illegible when filed

TABLE 2
PCAD+
Hair Follicle
Role
Morphogens/Signaling
Bmp2
Bmp4*
Dkk3#
Dkk4
Edar
Fgfr1#
Fzd7#
Hhip
Inhbb#
Ptch2
Pdgfa
Pdgfr1
Sgk
Shh
Tgfa
Tgfb2
Tgfb3
Wnt5a
Wif1#
Transcription
Factors
Bnc1#
Bnc2
Cutl1*
Gli1
Hoxc13
Nmyc1
Nfatc1#
Sox9#
Trps1#
Vdr#
Bcl6*
Bach2#
Dach1
Dlx2
Egr2*
Egr3
Foxc1#
Gtf2ird1#
Hmga2#
Id2#
Id4#
Isl1
Lhx2#
Lbh
Lass4
Mitf#
Myb*
Nfe2l3*
Nr4a1
Nap1l5
Prdm1
Prdm5
Rai14#
Runx1#
Runx2*
Scmh1#
Six4
Sox13#
Sox2
Sox21*
Tbx1#
Sp5
Tcf7
Tcfl5
Zfp566
PCAD−
Epidermal Role
Adhesion/Structural
Cldn1*
Dsc2#
Dsg1a
Evpl
Eppk1*
Jup
Krt1-10*
Krt1-14*
Krt1-15
Krt1-16*
Krt2-1*
Krt2-5
Krt2-6a#
Krt2-6b
Ocln
Ppl
pkp1*
Differentiation
BmpR1b
Dll1*
Dtx2
Jag1#
Krtdap*
Notch3*
Sprr2a
Sfn
Sbsn
Transcription
Factors
Esr1
Foxn1
Grhl1*
Grhl3
Klf4
Klf5*
Myc#
Ovol1*
Pou3f1*
Stat1
Tcfap2e
Ascl2*
Aff1
Ankrd22*
Ghr*
Ell2#
Hoxa1*
Mllt2h#
Irx3
Klf12
Klf3
Mafb*
Msl2
Mrg1*
Mef2c
Nfia
Nrip3#
Nr2f2
Ror1
Rora*
Satb1*
Spib
Sox6*
Sox7*
Tcfcp2l1
Note:
Expression of K14 and K5 genes was previously shown to be downregulated as basal embryonic epidermal cells commit to make a hair follicle; expression of K1 and K10 are typically expressed in terminally differentiating epidermal cells but a few basal cells have been shown to induce expression of these genes prior to detachment from the basement membrane. Thus, the reduced expressions of K14/K5 and K10/K1 in PCAD+ placodes relative to PCAD− basal cells (or in bulge cells relative to all skin epithelial cells) are in agreement with these points.

Claims

1. A method for modulating hair growth comprising regulating the expression or activity of Lhx2 so that hair growth is stimulated or inhibited.

2. A method for identifying an agent which modulates hair growth comprising contacting a test cell expressing a reporter operably linked to an Lhx2 promoter with an agent and detecting expression of the reporter in the test cell, wherein a decrease in reporter expression is indicative of an agent which stimulates hair growth and an increase in reporter expression is indicative of an agent which inhibits hair growth.