METHOD FOR PREDICTING THERAPEUTIC EFFECT OF IMMUNOTHERAPY ON CANCER PATIENT AND/OR PROGNOSIS AFTER IMMUNOTHERAPY, AND GENE SET AND KIT TO BE USED THERIN

Abstract

The present invention provides a method for predicting effect of immunotherapy on a cancer patient and/or prognosis of the cancer patient after the immunotherapy, and a gene set and a kit for use in the method.

Description

TECHNICAL FIELD

The present invention provides a method for predicting effect of immunotherapy on a cancer patient and/or prognosis of the cancer patient after the immunotherapy, and a gene set and a kit for use in the method. The present application claims the benefit of Japanese patent application number 2009-230279 and the subject matter of which is hereby incorporated herein by reference.

BACKGROUND ART

Cancer immunotherapy is still not an optimal therapeutic option for all patients although it has been effective for some patients. One of the reasons is that immunotherapy relys on immunity which considerably varies among different individuals to suppress proliferation of cancer cells. At present, it is not possible to predict effect of cancer immunotherapy and thus effectiveness of the therapy cannot be determined unless the therapy has done. It has been known that effect of chemotherapy on a breast cancer patient is predicted by determination of gene expression level. However, this prediction method is complicated because it involves not only gene expression level but also other factors. In addition, this method only directs to chemotherapy on breast cancer (patent literature 1). So far, methods for predicting effect of cancer immunotherapy or prognosis of a patient after immunotherapy have not been known.

• Patent literature: JP-A-2008-536094

Disclosure of Invention

Problem to be Solved by the Invention

An object of the present invention is to provide a method for predicting effect of immunotherapy on a cancer patient with accuracy.

Means of Solving the Problem

Based on the results of peptide vaccine therapy on prostate cancer patients over the years, the present inventors tried to predict effect of cancer immunotherapy. First, gene expression profiles of prostate cancer patients before peptide vaccine therapy were analyzed with DNA micorarray. Then, the patients were classified into good prognosis group and poor prognosis group according to their survival time after the therapy, and correlation between expression level of each gene before the therapy and survival time after the therapy was analyzed. As a result, some genes were found to have correlation between the two. Finally, it was confirmed that survival time of a patient after immunotherapy could be predicted from expression level of those genes and the present invention has been accomplished.

Thus, the present invention provides a method for predicting effect of immunotherapy on a cancer patient and/or prognosis of the cancer patient after the immunotherapy, which comprises the steps of:

(1) determining expression level of each gene in a gene set which consists of at least 1 gene selected from the group of genes shown in any of Tables 1-5 and(2) performing statistical processing of the expression level to calculate predicted survival time.

The present invention further provides a gene set for predicting effect of immunotherapy on a cancer patient and/or prognosis of the cancer patient after the immunotherapy, which consists of at least 1 gene selected from the group of genes shown in any of Tables 1-5.

The present invention further provides a kit for predicting effect of immunotherapy on a cancer patient and/or prognosis of the cancer patient after the immunotherapy, which comprises a probe or primer for each gene in the aforementioned gene set.

Effect of the Invention

According to the present invention, it has become possible to predict effect of immunotherapy on a cancer patient and/or prognosis of the cancer patient after the immunotherapy by determining gene expression profile of the cancer patient before initiation of the immunotherapy. The present invention can offer useful information in selecting therapeutic options for cancer patients.

BRIEF DESCRIPTION OF DRAWINGS

FIG. 1 Distribution of predicted survival time of 40 prostate cancer patients.

FIG. 2 Pre-processing of microarray data.

FIG. 3 Distribution of top 300 genes selected by Pearson product-moment correlation coefficient.

FIG. 4 Accuracy of survival time prediction by different gene selection methods.

FIG. 5 Accuracy of survival time prediction with 30 gene sets each consisting of genes selected in descending order from the top (the first gene) of top 300 genes selected by Pearson product-moment correlation coefficient (Table 1). The vertical axis represents number of patients correctly predicted.

FIG. 6 Comparison between predicted survival time (calculated with the gene set consisting of top 50 genes selected by Pearson product-moment correlation coefficient, latent variable 3) and actual survival time of each patient.

FIG. 7 Kaplan-Meier curve prepared according to the results of survival time prediction.

FIG. 8 Accuracy of survival time prediction with 30 gene sets each consisting of genes selected in ascending order from the bottom (the 300th gene) of top 300 genes selected by Pearson product-moment correlation coefficient (Table 1). The vertical axis represents number of patients correctly predicted.

FIG. 9 Accuracy of survival time prediction with 30 gene sets each consisting of genes randomly selected from top 300 genes selected by Pearson product-moment correlation coefficient (Table 1). The vertical axis represents number of patients correctly predicted.

FIG. 10 Results of survival time prediction with good prognosis group (survival time was 300 days or more) and poor prognosis group (survival time was less than 300 days).

FIG. 11-1 Results of survival time prediction with one gene randomly selected from top 300 genes selected by Pearson product-moment correlation coefficient (Table 1) (1) (the rank in Table 1 is shown in the left of each graph).

FIG. 11-2 Results of survival time prediction with one gene randomly selected from top 300 genes selected by Pearson product-moment correlation coefficient (Table 1) (2) (the rank in Table 1 is shown in the left of each graph).

FIG. 11-3 Results of survival time prediction with one gene randomly selected from top 300 genes selected by Pearson product-moment correlation coefficient (Table 1) (3) (the rank in Table 1 is shown in the left of each graph).

DESCRIPTION OF EMBODIMENTS

The prediction method of the present invention uses a gene or genes of which expression levels closely correlate survival time of a cancer patient after immunotherapy. The gene set of the present invention consists of at least 1 gene selected from the group of genes shown in any of Tables 1-5. The genes may be selected from any of Tables 1-5 in descending order from the top (the first gene), in ascending order from the bottom (the 300th gene), or randomly. In view of prediction accuracy, the genes are preferred to be selected in descending order from the top of any of the tables.

Number of genes in a gene set is not specifically limited and may be 1 or more. For example, for a gene set, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 20, 30, 40, 50, 60, 70, 80, 90, 100, 110, 120, 130, 140, 150, 160, 170, 180, 190, 200, 210, 220, 230, 240, 250, 260, 270, 280, 290, or 300 genes may be selected.

The cancer patient to be treated by the present invention may be, but not limited to, a cancer patient of prostate cancer, pancreatic cancer, breast cancer, or liver cancer. Particularly, the present invention is suitable for a prostate cancer patient.

In the present invention, immunotherapy refers to a therapeutic method for treating cancer by stimulating immune response in a cancer patient against a tumor antigen protein. The immunotherapy of the present invention may include peptide vaccine therapy which uses a tumor antigen peptide, adoptive immunotherapy which uses lymphocytes such as cytotoxic T cells or natural killer cells, DNA vaccine therapy wherein a virus vector expressing a tumor antigen protein or peptide is introduced into a living body, and dendritic cell vaccine therapy wherein dendritic cells presenting a tumor antigen peptide are administered. Particularly, the present invention is suitable for peptide vaccine therapy.

In the present invention, expression level of a gene may be determined by any conventional method. Methods for determining expression level of a gene may include DNA microarray analysis, DNA chip analysis, PCR analysis, and Northern blot analysis, and particularly, DNA microarray analysis is suitable for the present invention.

DNA microarray analysis uses a microarray containing a probe for a gene to be determined. The microarray may be HumanWG-6 v3.0 Expression BeadChip (llumina). Alternatively, it is possible to prepare any desired microarray by synthesizing a probe for a gene to be determined and immobilizing the probe on a suitable substrate such as a slide glass. Methods for preparing a microarray are well known in the art. Analysis of microarray data is also well known in the art and may be performed according to MICROARRAYS FOR AN INTEGRATIVE GENOMICS, translated by Yujin Hoshida, Springer-Verlag Tokyo, for example.

A patient-derived sample used for determination of expression level of a gene may be, but not limited to, peripheral blood collected from a patient.

Expression level of a gene may be determined by DNA microarray analysis as follows. Briefly, total RNA is extracted and purified from peripheral blood of a patient. Then, biotinated cRNA is synthesized by using, for example, Illumina TotalPrep RNA Amplification Kit (Ambion). The biotinated cRNA is hybridized to a microarray and reacted with Cy3-labeled streptavidin. The resulting microarray is scanned by a dedicated scanner and Cy3 fluorescence of each spot is quantified by a dedicated software such as BeadStudio. Accordingly, expression level of the gene may be determined.

Predicted survival time of a patient may be calculated, for example, by applying the expression level of each gene of the gene set of the present invention in the patient into the regression equation of PLS regression analysis as shown in the following examples. Alternatively, it may be calculated by determining expression level of each gene of any gene set of the present invention in the patient group of the examples or other patient groups and performing statistical processing by SVM (Support Vector Machine), Regularized Least Squares, or Principal Component Analysis.

The gene set of the present invention is used for predicting effect of immunotherapy on a cancer patient and/or prognosis of the cancer patient after the immunotherapy and may be used for preparing a probe for DNA microarray or a primer for PCR for use in the prediction method of the present invention.

The kit of the present invention comprises a probe or primer which is capable of determining expression level of each gene of the gene set of the present invention. The probe or primer for each gene may be synthesized by a conventional method based on the sequence of the gene. The kit may comprise other reagents required for determination of expression level. The kit of the present invention may be used for DNA microarray analysis, DNA chip analysis, PCR analysis, and Northern blot analysis. A kit for DNA microarray analysis may comprise a microarray containing the probe as described above immobilized on a suitable substrate.

EXAMPLES

Example 1

1. Analysis of Gene Expression Profile Before Peptide Vaccine Therapy Using DNA Microarray

Patient-derived samples were peripheral blood which had been collected from prostate cancer patients who gave informed consent under the protocol approved by Kurume University ethical committee when the patients were diagnosed as recurrent prostate cancer in the past clinical trials. Gene expression profiles of 40 prostate cancer patients before peptide vaccine therapy were analyzed by using DNA microarray (HumanWG-6 v3.0 Expression BeadChip (Ilumina)). The prostate cancer patients included 20 good prognosis patients (whose survival time after peptide vaccine therapy was 700 days or more) and 20 poor prognosis patients (whose survival time after peptide vaccine therapy was less than 700 days) (FIG. 1).

(I) RNA Extraction and Purification from Peripheral Blood of Patients1. To peripheral blood sample of a patient, TRIzol LS (Invitrogen) was added at a ratio 1:3 and mixed such that the mixture became turbid.2. To 750 μl TRIzol LS solution, 200 μl chloroform was added and mixed such that the mixture became turbid, and the resulting solution was centrifuged.3. The supernatant obtained was removed to a fresh tube and added with ethanol 0.55 times as much as the supernatant.4. The sample obtained in item 3 was mounted on a column of SV Total RNA Isolation System (Promega) and passed through the filter.5. The filter was washed with 500 μl washing buffer.6. Total RNA was eluted with 80 μl nuclease-free water.7. Concentration of RNA was determined by using a spectrophotometer, and quality of RNA was checked by electrophoresis by using Experion system (Biorad).(II) cRNA Synthesis for Microarray Using Illumina TotalPrep RNA Amplification Kit (Ambion)(1) Synthesis of Single-Stranded cDNA by Reverse Transcription1. To 500 μg total RNA each, nuclease-free water was added up to 11 μl.2. The solution obtained item 1 was added with 9 μl Reverse Transcription Master Mix and incubated for 2 hours at 42° C.

(2) Synthesis of Double-Stranded DNA

1. To the tube of item (1)-2, 80 μl Second Strand Master Mix was added.2. The tube was incubated for 2 hours at 16° C.(3) Purification of cDNA1. To the tube, 250 μl cDNA Binding Buffer was added.2. The solution obtained in item 1 was mounted on cDNA Filter Cartridge and passed through the filter by centrifugation.3. The filter was washed with 500 μl washing buffer.4. cDNA was eluted with 19 μl nuclease-free water which was pre-heated to 50-55° C.(4) Synthesis of cRNA by Reverse Transcription Reaction In Vitro1. To the cDNA sample obtained in item (3)-4, 7.5 μl IVT Master Mix was added.2. The tube obtained in item 1 was incubated for 14 hours at 37° C.3. To the tube obtained in item 2, 75 μl nuclease-free water was added.(5) Purification of cRNA1. To the tube, 350 μl cRNA Binding Buffer was added.2. To the tube, 250 μl of 100% ethanol was added and mixed such that the mixture became turbid.3. The sample obtained in item 2 was mounted on tRNA Filter Cartridge and passed through the filter by centrifugation.4. The filter was washed with 650 μl washing buffer.5. cRNA was eluted with 100 μl nuclease-free water which was pre-heated to 50-55° C.6. Concentration of cRNA of the resulting solution was determined and the solution was used as a hybridization sample.

(III) Microarray Hybridization

(1) Preparation of cRNA for hybridization1. To 500 μg total RNA, nuclease-free water was added up to 10 μl.2. The solution obtained in item 1 was added with 20 μl GEX-HYB and incubated for 5 minutes at 65° C.

(2) Hybridization

1. cRNA sample thus prepared was applied to HumanWG-6 v3.0 Expression BeadChip placed in a dedicated chamber.2. The dedicated chamber was covered and incubated for 18 hours at 55° C.

(IV) Washing and Staining of Microarrays

(1) Washing of Microarrays

1. The covers of the microarrays were removed in Wash E1BC solution.2. The arrays were immediately set in a slide rack and washed with 1×High-Temp Wash buffer which was pre-heated to 55° C.3. The arrays were washed in Wash E1BC solution for 5 minutes.4. The arrays were washed in ethanol for 5 minutes.5. The arrays were washed in Wash E1BC solution for 5 minutes.6. To each of staining trays 4 ml Block E1 buffer was added, and then the arrays were set in the staining trays one by one to perform blocking for 10 minutes at room temperature.7. To each of staining trays 2 μl streptoavidin-Cy3 per 2 ml Block E1 buffer was added, and then the arrays were set in the staining trays one by one to perform staining for 10 minutes at room temperature.8. The arrays were washed in Wash E1BC solution for 5 minutes and dried by centrifugation.

(V) Scanning and Quantification

1. The arrays were set in a dedicated scanner (Illumina) and scanned in a standard mode.2. After scanning, each spot on the microarrays was quantified by using a dedicated software BeadStudio.

The microarray data obtained was normalized with VST (Variance Stabilizing Transformation) and RSN (robust spline normalization). Expression level of a gene was determined to be significant when the gene showed Presence Probability &#60 0.05 compared to a negative control (expression level measured with a probe for a gene which was not present in the microarray) (FIG. 2). The following analysis was performed using the genes showing Presence Probability &#60 0.05 in 70% or more of the 40 patients.

2: Selection of a Gene Set for Building PLS Regression Model

The prostate cancer patients of Example 1 were classified into 2 groups, good prognosis group (survival time after peptide vaccine therapy was 700 days or more) and poor prognosis group (survival time after peptide vaccine therapy was less than 700 days) and genes were selected based on correlation between expression level of each gene and survival time, and expression variation between the two groups. Expression variation was represented as increase or decrease of mean expression level of poor prognosis group compared to that of good prognosis group as a control.

For analysis, the following five statistical methods were used (A: method for analysis of correlation between expression level of a gene and survival time, B: method for analysis of expression variation between good prognosis group and poor prognosis group).

• • Pearson product-moment correlation coefficient (A)
  • Limma^b (B)
  • SAM^a (B)
  • Rank Prod^c (B)
  • Spearman's rank correlation coefficient (A)

REFERENCES

• ^a Tusher et al. Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci USA (2001) vol. 98 (9) pp. 5116-21.
• ^b Smyth. Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Statistical applications in genetics and molecular biology (2004) vol. 3 pp. Article.
• ^c Breitling et al. Rank products: a simple, yet powerful, new method to detect differentially regulated genes in replicated microarray experiments. FEBS Letters (2004) vol. 573 (1-3) pp. 83-92.

Those references are herein incorporated by reference.

3: Analysis of PLS Regression Model

PLS (Partial Least Square) regression model was built for prediction of survival time of each patient after peptide vaccine therapy. Specifically, from each of the five gene sets consisting of top 300 genes selected by one of the above five methods, respectively (Tables 1-5, FIG. 3), 30 gene sets each comprising genes in multiples of 10 (i.e. 10, 20, . . . or 300 genes) from the top were extracted. Then, PLS regression model was built with latent variable 1 to 10.

Analysis of the regression model was performed according to Leave One Out Cross Validation (LOOCV) method. Namely, for 40 prostate cancer patients in total, regression model was built using results of 39 patients, and the regression model thus built was used to predict survival time of the remaining 1 patient.

For example, calculation of survival time with a gene set consisting of top 50 genes is as follows. Predicated survival time was calculated according to the following regression equation.

Predicated survival time=a1g1+a2g2+a3g3+ . . . +a50g50+E  (formula 1),

wherein each of a1, a2, a3, . . . and a50 is a coefficient for expression level of a gene used to build the regression model; each of g1, g2, g3, g4, . . . g50 is expression level of a gene in a patient to be analyzed; and E is a constant term of the regression equation).

Table 6 shows coefficients used for the prediction of survival time of patients with the gene set consisting of top 50 genes selected by Pearson product-moment correlation coefficient, latent variable 3.

REFERENCES

• [1] Bjrn-Helge Mevik and Ron Wehrens Journal of Statistical Software: Vol 18, Issue 2 (2007), " The pls Package: Principal Component and Partial Least Squares Regression in R"
• [2] Geladi, P. and B. Kowalski (1986) Partial least-squares regression: Atutorial. Analytica Chimica Acta 185:1-17.

Those references are herein incorporated by reference.

The answer was determined to be correct when the predicted survival time was 700 days or more for a good prognosis patient or less than 700 days for a poor prognosis patient, and accuracy rate (prediction accuracy) of the regression model was calculated. When evaluated, all the regression models showed the best prediction accuracy more than 80% (FIG. 4). Particularly, the gene set consisting of top 50 genes selected by Pearson product-moment correlation coefficient, latent variable 3 showed the highest prediction accuracy, which was 95%. Prediction accuracy of survival time prediction with this gene set and comparison between the predicted survival time and the actual survival time are shown in FIGS. 5 and 6. For the patients in the right-upper and left-lower sections in FIG. 6, predicted survival time reflected actual survival time. For the patients in the left-upper section, prognosis after the immunotherapy was predicted as good, but actual survival time was shorter than the prediction. On the other hand, there was no patient whose prognosis was predicted as poor but actual survival time was longer than the prediction (FIG. 6, the right-lower section). Those results indicate that the method of the present invention can predict a patient who would not be efficiently treated by immunotherapy before initiation of the immunotherapy.

In addition, Kaplan-Meier curve was prepared using actual survival time of good and poor prognosis groups classified with the gene set consisting of: top 50 genes selected by Pearson product-moment correlation coefficient, latent variable 3 and then log rank test was performed. As a result, it was revealed that the present method could classify the patients into good and poor prognosis groups with probability p=1.6e-10 (FIG. 7).

Then, from the gene set of Table 1, 30 gene sets each consisting of genes in multiples of 10 (i.e., 10, 20, . . . or 300 genes) in ascending order from the bottom were extracted and PLS regression model was built with latent variable 3 (FIG. 8). In this case, prediction accuracy was 65-85%. Also, from the same gene set, 30 gene sets were extracted randomly (Table 7) and PLS regression model was built with latent variable 3 (FIG. 9). In this case, prediction accuracy was 62.5-85%. Those results demonstrate that survival time after immunotherapy can be predicted by any gene selection method.

Example 2

Gene Expression data of 9 prostate cancer patients were further included in addition to those of 40 prostate cancer patients of Example 1, and the patients were classified into good prognosis group (survival time was 300 days or more) and poor prognosis group (survival time was less than 300 days). Then, PLS regression model was built with a gene set consisting of top 50 genes selected by Pearson product-moment correlation coefficient, latent variable 3 and survival time of the 9 prostate cancer patients newly included were predicted (FIG. 10). In this example, prediction was correct in 8 of 9 patients.

Example 3

For 40 prostate cancer patients of Example 1, a primary linear regression equation was prepared according to their survival time and expression level of one of top 300 genes selected by Pearson product-moment correlation coefficient (Table 1). Then, predicted survival time of a patient was calculated with the equation thus prepared and expression level in the patient, and the calculated predicted survival time (y axis) and actual survival time (x axis) were shown in a graph (FIG. 11). The graphs show results of 10 genes randomly selected from Table 1 by generating a random number between 1 and 300 and regarding the number as a rank in the table. As a result, it was demonstrated that survival time could be predicted based on expression level of only one gene.

TABLE 1
List of top 300 genes selected by Pearson product-moment correlation coefficient.
Pearson
No.	Probe ID	Name of gen	Description of gene	EntrezID	Acc	limma_logFC	Cor_Pearson_R	Cor_Pearson_absR	Cor_Pearson_Pval	Cor_Pearson_adPval
1	3390368	PDP2	—	57546	NM_020786.1	0.068777448	−0.640094678	0.640094678	8.68E−06	0.0806
2	1300687	NULL	NULL	731950	XR_016039.1	−0.061135983	0.631328974	0.631328974	1.25E−05	0.0806
3	5860465	USP9Y	“ubiquitin specific peptidase 9, Y-	8287	NM_004654.3	−0.094524102	0.628214485	0.628214485	1.42E−05	0.0806
			linked (fat facets-like, Drosophila)”
4	4390576	DFFA	“DNA fragmentation factor, 45 kDa,	1678	NM_213566.1	0.121909434	−0.601015195	0.601015195	4.12E−05	0.1137
			alpha polypeptide”
5	4830255	DPP4	dipeptidyl-peptidase 4	1803	NM_001935.3	−0.307400855	0.598684997	0.598684997	4.49E−05	0.1137
6	4570403	NULL	NULL	NULL	BX106581	0.112837902	−0.591426067	0.591426067	5.85E−05	0.1137
7	1780719	PTGES3	prostaglandin E synthase 3	10728	NM_006601.4	−0.528677962	0.586249078	0.586249078	7.04E−05	0.1137
			(cytosolic)
8	3130477	C7orf28A	chromosome 7 open reading frame	51622	XM_001133729.1	−0.383441629	0.585298251	0.585298251	7.28E−05	0.1137
			28A
9	6110630	HIST1H2BK	“histone cluster 1, H2bk”	85236	NM_080593.1	0.379122401	−0.583688805	0.583688805	7.70E−05	0.1137
10	3310309	CCDC135	coiled-coil domain containing 135	84229	NM_032269.4	0.099558313	−0.582768194	0.582768194	7.96E−05	0.1137
11	4220731	P4HA1	“prolyl 4-hydroxylase, alpha	5033	NM_000917.2	−0.307837835	0.582543435	0.582543435	8.02E−05	0.1137
			polypeptide 1”
12	520706	UBE4A	“ubiquitination factor E4A (UFD2	9354	NM_004788.2	−0.230502672	0.582455331	0.582455331	8.04E−05	0.1137
			homolog, yeast)”
13	6420446	CMPK1	“cytidine monophosphate (UMP-	51727	NM_016308.1	−0.398631213	0.576832021	0.576832021	9.78E−05	0.1276
			CMP) kinase 1, cytosolic”
14	1400240	LDHB	lactate dehydrogenase B	3945	NM_002300.4	−0.605485777	0.573136201	0.573136201	0.000110918	0.1341
15	7510379	SACS	spastic ataxia of Charlevoix-	26278	NM_014363.3	−0.121241812	0.571175816	0.571175816	0.000118529	0.1341
			Sag enay (sacsin)
16	2640025	HP	haptoglobin	3240	NM_005143.2	0.40681683	−0.565414687	0.565414687	0.000143707	0.1412
17	3130296	AMY2A	“amylase, alpha 2A (pancreatic)”	279	NM_000699.2	−0.282794372	0.562912837	0.562912837	0.000156073	0.1412
18	3520601	MPO	myeloperoxidase	4353	NM_000250.1	0.96554979	−0.560650984	0.560650984	0.000168071	0.1412
19	1110091	TIAL1	TIA1 cytotoxic granule-associated	7073	NM_001033925.1	−0.233908998	0.560267499	0.560267499	0.000170186	0.1412
			RNA binding protein-like 1
20	3130370	ZNF83	zinc finger protein 83	55769	NM_018300.2	−0.30567958	0.557785556	0.557785556	0.000184463	0.1412
21	2030332	PTPN18	“protein tyrosine phosphatase,	26469	NM_014369.2	0.083763446	−0.556808508	0.556808508	0.000190373	0.1412
			non-receptor type 18 (brain-
			derived)”
22	670209	ZNF700	zinc finger protein 700	90592	NM_144566.1	−0.134476397	0.556120039	0.556120039	0.00019464	0.1412
23	6560161	NULL	NULL	NULL	BX111675	0.054993081	−0.555033755	0.555033755	0.000201547	0.1412
24	1740647	FAM180B	“family with sequence similarity	399888	XM_941808.2	0.083819707	−0.552949574	0.552949574	0.000215422	0.1412
			180, member B”
25	4880463	SEC24A	“SEC24 family, member A	10802	NM_021982.1	−0.069649892	0.551748217	0.551748217	0.000223805	0.1412
			(S. cerevisiae)”
26	990315	TCP1	t-complex 1	6950	NM_030752.2	−0.256767834	0.548462787	0.548462787	0.00024825	0.1412
27	240463	RNF216L	ring finger protein 216-like	441191	XR_001271.1	0.162378967	−0.546624738	0.546624738	0.000262951	0.1412
28	2000035	NULL	NULL	NULL	AL042883	0.08373784	−0.545628461	0.545628461	0.000271242	0.1412
29	1780709	DDX17	DEAD (Asp-Glu-Ala-Asp) box	10521	NM_030881.2	−0.443292451	0.54494961	0.54494961	0.000277025	0.1412
			polypeptide 17
30	2680440	NULL	NULL	NULL	BF338665	0.061724508	−0.544896308	0.544896308	0.000277484	0.1412
31	150672	KLHL7	kelch-like 7 (Drosophila)	55975	NM_001031710.1	−0.155913324	0.544163441	0.544163441	0.000283861	0.1412
32	6940176	ACTR3	ARP3 actin-related protein 3	10098	NM_005721.3	−0.459963089	0.543431629	0.543431629	0.00029036	0.1412
			homolog (yeast)
33	6180497	GOLGA8C	“golgi autoantigen, golgin subfamily	400304	XM_375152.3	−0.242008817	0.542516269	0.542516269	0.000298677	0.1412
			a. 8C”
34	150706	UGP2	UDP-glucose pyrophosphorylase 2	7360	NM_006759.3	−0.347146055	0.542493196	0.542493196	0.000298889	0.1412
35	5900129	CROP	—	51747	NM_006107.2	−0.443849065	0.541743162	0.541743162	0.000305867	0.1412
36	6450437	NULL	NULL	NULL	BF445990	0.102742584	−0.541344228	0.541344228	0.000309638	0.1412
37	3990608	MAN2A1	“mannosidase, alpha, class 2A,	4124	NM_002372.2	−0.327379686	0.540749807	0.540749807	0.000315334	0.1412
			member 1”
38	3120075	TIA1	TIA1 cytotoxic granule-associated	7072	NM_022173.1	−0.154497679	0.540658588	0.540658588	0.000316217	0.1412
			RNA binding protein
39	1500047	RIN1	Ras and Rab interactor 1	9610	NM_004292.2	0.132155916	−0.537690388	0.537690388	0.000346168	0.1475
40	840358	EXOSC10	exosome component 10	5394	NM_002685.2	−0.226165883	0.53626305	0.53626305	0.000361457	0.1475
41	6590484	NAP1L1	nucleosome assembly protein 1-like 1	4673	NM_139207.1	−0.357418466	0.535985012	0.535985012	0.000364505	0.1475
42	2100594	BUB3	budding uninhibited by	9184	NM_004725.2	−0.303182523	0.535031257	0.535031257	0.000375136	0.1475
			benzimidazoles 3 homolog (yeast)
43	6650056	ZNF566	zinc finger protein 566	84924	NM_032838.2	−0.051770571	0.53472561	0.534725261	0.000378605	0.1475
44	2120017	NOL8	nucleolar protein 8	55035	NM_017948.4	−0.183491166	0.534382962	0.534382962	0.00038252	0.1475
45	1780639	LOC645355	—	845355	XM_932842.1	0.036028447	−0.532604561	0.532604561	0.000403449	01481
46	6650594	ATP11B	“ATPase, class VI, type 11B”	23200	NM_014616.1	−0.252853775	0.531209574	0.531209574	0.000420578	0.1481
47	3420136	C6orf222	chromosome 6 open reading frame	389384	NM_001010903.3	0.050501562	−0.531038639	0.531038639	0.000422721	0.1481
			222
48	6760017	YY1	YY1 transcription factor	7528	NM_003403.3	−0.328869705	0.530931836	0.530931836	0.000424065	0.1481
49	510209	LOC643310	—	643310	XM_926656.1	−0.395581648	0.530359688	0.530359688	0.00043133	0.1481
50	4220873	NULL	NULL	NULL	AA971450	0.072927449	−0.529035258	0.529035258	0.000448577	0.1481
51	7650497	ELA2	“elastase 2, neutrophil”	1991	NM_001972.2	1.319902436	−0.527751453	0.527751453	0.000465881	0.1481
52	2650601	GPBP1L1	GC-rich promoter binding protein	60313	NM_021639.3	−0.185092124	0.526741783	0.526741783	0.000479908	0.1481
			1-like 1
53	4880521	CDC16	cell division cycle 16 homolog	8881	NM_003903.3	−0.34380491	0.526389836	0.526389836	0.000484886	0.1481
			(S. cerevisiae)
54	5720300	G3BP1	GTPase activating protein (SH3	10146	NM_005754.2	−0.241645343	0.526197011	0.526197011	0.000487632	0.1481
			domain) binding protein 1
55	7210279	NULL	NULL	NULL	AA431552	0.088033112	−0.52587792	0.52587792	0.000492208	0.1481
56	840064	LOC645489	—	645489	XM_928514.1	−0.199041088	0.525473195	0.525473195	0.000498067	0.1481
57	5960072	NULL	NULL	NULL	BY797688	−0.097047292	0.525204521	0.525204521	0.00050199	0.1481
58	3610521	PCDHGB6	“protocadherin gamma subfamily B, 6”	56100	NM_018926.2	0.176789549	−0.524908903	0.524908903	0.00050634	0.1481
59	770441	DOPEY1	dopey family member 1	23033	NM_015018.2	−0.10084509	0.520195136	0.520195136	0.000580393	0.1577
60	5810619	TADA1L	“transcriptional adaptor 1 (HFI1	117143	NM_053053.2	−0.16203449	0.519513067	0.519513067	0.000591874	0.1577
			homolog, yearst)-like”
61	4260767	GP1BA	“glycoprotein Ib (platelet), alpha	2811	NM_000173.4	0.13089936	−0.519405182	0.519405182	0.000593708	0.1577
			polypeptide”
62	5290358	CPT1A	carnitine palmitoyltransferase 1A	1374	NM_001031847.1	0.165571989	−0.518548295	0.518549295	0.000608441	0.1577
			(liver)
63	3440189	ZBTB20	zinc finger and BTB domain	26137	NM_015642.3	−0.287117754	0.518214913	0.518214913	0.000614286	0.1577
			containing 20
64	4050195	FAM10A4	“family with sequence similarity 10,	145165	NR_002183.1	−0.370567771	0.517317921	0.517317921	0.000630211	0.1577
			member A4 pseudogene”
65	160253	MBNL1	muscleblind-like (Drosophila)	4154	NM_207295.1	−0.320695796	0.517296744	0.517296744	0.000630591	0.1577
66	6550164	DEFA4	“defensin, alpha 4, corticostatin”	1669	NM_001925.1	1.278228028	−0.516993333	0.516993333	0.000838064	0.1577
67	2710653	FBXO38	F-box protein 38	81545	NM_030793.3	−0.149047116	0.51550975	0.51550975	0.000663438	0.1577
68	7200433	NULL	NULL	NULL	BF434110	0.123387473	−0.515143069	0.515143069	0.000670364	0.1577
69	4210129	ELOVL5	“ELOVL family member 5,	60481	NM_021814.3	−0.284710319	0.515004341	0.515004341	0.000673001	0.1577
			elongation of long chain fatty acids
			(FEN1/Elo2, SUR4/Elo3-like,
70	270544	NR2C1	“nuclear receptor subfamily 2,	7181	NM_003297.1	−0.155303368	0.514911933	0.514911933	0.000674763	0.1577
			group C, member 1”
71	1710646	C11orf63	chromosome 11 open reading frame	79864	NM_024806.2	−0.036113925	0.513815279	0.513815279	0.000695986	0.1577
			63
72	4250154	NULL	NULL	648749	XM_937834.2	−0.061658345	0.513627958	0.513627958	0.00069967	0.1577
73	5670739	AZU1	azurocidin 1	566	NM_001700.3	0.606626505	−0.513100443	0.513100443	0.000710138	0.1577
74	3990563	IFNA10	“interferon, alpha 10”	3446	NM_002171.1	0.151388979	−0.512771949	0.512771949	0.000716727	0.1577
75	6200678	NULL	NULL	NULL	AA889171	0.058541514	−0.512743528	0.512743528	0.000717299	0.1577
76	2320577	SSR2	“signal sequence receptor, beta	6746	XM_945427.1	0.064320484	−0.512114597	0.512114597	0.000730076	0.1577
			(translocon-essociated protein
			beta)”
77	7160332	NULL	NULL	NULL	CF552427	0.054930882	−0.512069207	0.512069207	0.000731006	0.1577
78	1570392	IL21R	interleukin 21 receptor	50615	NM_181078.1	0.057079914	−0.512060675	0.512060675	0.000731181	0.1577
79	450195	Sept7	septin 7	989	NM_001788.4	−0.31815245	0.511500444	0.511500444	0.000742747	0.1577
80	6590278	CBX2	“chromobox homolog 2 (Pc class	84733	NM_005189.1	0.077041967	−0.511473889	0.511473889	0.0007433	0.1577
			homolog Drosophila)”
81	6280521	NULL	NULL	648399	XM_937448.1	−0.092941768	0.509883609	0.509883609	0.000777049	0.1621
82	4810072	TUSC2	tumor suppressor candidate 2	11334	NM_007275.1	0.162628207	−0.509587506	0.509587506	0.000783482	0.1621
83	2600204	SACM1L	SAC1 suppressor of actin	22908	NM_014016.2	−0.262966982	0.508788843	0.508788843	0.000801069	0.1638
			mutations 1-like (yeast)
84	2360672	TNFRSF19	“tumor necrosis factor receptor	55504	NM_148957.2	0.070969941	−0.507699006	0.507699006	0.000825635	0.1661
			superfamily, member 19”
85	4010195	COL6A2	“collagen, type VI, alpha 2”	1292	NM_058175.2	0.063152686	−0.507000048	0.507000048	0.00084174	0.1661
86	4850093	NULL	NULL	649596	XM_938659.1	0.101165023	−0.506996656	0.506996656	0.000841819	0.1661
87	3930561	PRKCI	“protein kinase C. iota”	6584	NM_002740.5	−0.105841727	0.506274935	0.506274935	0.000856744	0.1675
88	2970196	DEFB125	“defensin, beta 125”	245938	NM_153325.2	0.07618092	−0.505487341	0.505487341	0.000877558	0.1684
89	2850379	NULL	NULL	NULL	BC032017	0.065153173	−0.504716304	0.504716304	0.00089633	0.1684
90	7320424	HNRPA1L-2	—	664709	NR_002944.2	−0.432630765	0.504548219	0.504548219	0.00090047	0.1684
91	2070019	UBA6	ubiquitin-like modifier activating	55236	NM_018227.5	−0.194843638	0.504433181	0.504433181	0.000903313	0.1684
			enzyme 6
92	2940767	CEBPE	“CCAAT/enhancer binding protein	1053	NM_001805.2	0.145286933	−0.503471709	0.503471709	0.000927387	0.171
			(C/EBP), epsilon”
93	5910463	PKIA	“protein kinase (cAMP-dependent,	5569	NM_006823.2	−0.254561014	0.501973023	0.501973023	0.000966051	0.1714
			catalytio) inhibitor alpha”
94	6550750	ARMC8	armadillo repeat containing 8	25852	NM_014154.2	−0.087200394	0.501272073	0.501272073	0.000984621	0.1714
95	4010632	LQK1	—	642948	XM_927142.1	0.072739876	−0.500272952	0.500272952	0.001011638	0.1714
96	2350288	NULL	NULL	NULL	CA429430	0.061870864	−0.500162546	0.500162546	0.001014664	0.1714
97	5420053	CCT6P1	“chaperonin containing TCP1,	643253	NR_003110.2	−0.281922881	0.49954008	0.49954008	0.001031872	0.1714
			subunit 6 (zeta) pseudogene 1”
98	4590692	PCDH24	protocadherin 24	54825	NM_017675.3	0.053628265	−0.499137989	0.499137989	0.001043126	0.1714
99	840601	MEGF10	multiple EGF-like-domains 10	84466	NM_032446.1	0.047723662	−0.499051274	0.499051274	0.001045567	0.1714
100	1500735	CTSG	cathepsin G	1511	NM_001911.2	1.254662256	−0.498929923	0.498929923	0.001048992	0.1714
101	7650524	BCAT1	“branched chain aminotransferase	586	NM_005504.4	0.161097122	−0.498874361	0.498874361	0.001050563	0.1714
			1, cytosolic”
102	4570170	KIAA0947	—	23379	NM_015325.1	−0.180354486	0.498739242	0.498739242	0.001054393	0.1714
103	2370041	LRRN3	leucine rich repeat neuronal 3	54674	NM_018334.3	−0.383213794	0.498520298	0.498520298	0.001060626	0.1714
104	2120537	SPOCD1	SPOC domain containing 1	90853	NM_144569.4	0.09473433	−0.498432827	0.498432827	0.001063125	0.1714
105	7560300	TCTEX1D1	Tctex1 domain containing 1	200132	NM_152665.1	0.124259481	−0.498376405	0.498376405	0.001064739	0.1714
106	5550711	SYNE1	“spectrin repeat containing, nuclear	23345	NM_182951.2	0.075512374	−0.497880756	0.497880756	0.001079019	0.1714
			envelope 1”
107	3060288	NAIP	“NLR family, apoptosis inhibitory	4671	NM_004536.2	0.073560957	−0.497822596	0.497822596	0.001080705	0.1714
			protein”
108	6380373	TUBE1	“tubulin, epsilon 1”	51175	NM_016262.3	−0.138726153	0.496861389	0.496861389	0.00110892	0.1742
109	990044	KIAA1147	KIAA1147	57189	XM_001130020.1	−0.162506963	0.496349996	0.496349996	0.001124197	0.175
110	7380707	ZFAND1	“zine finger, AN1-type domain 1”	79752	NM_024699.1	−0.254784176	0.495918538	0.495918538	0.00113723	0.1751
111	5720703	AKTIP	AKT interacting protein	64400	NM_022476.2	−0.132110131	0.495659163	0.495659163	0.001145129	0.1751
112	6520315	NULL	NULL	NULL	BC033504	0.0764326	−0.494719268	0.494719268	0.001174163	0.1779
113	270091	C19orf68	chromosome 19 open reading frame	374920	NM_199341.1	0.052642885	−0.494044806	0.494044806	0.001195398	0.1787
			68
114	580014	C12orf43	chromosome 12 open reading frame	64897	NM_022895.1	−0.20852646	0.493884539	0.493884539	0.001200494	0.1787
			43
115	1170268	PRMT1	protein arginine methyltransferase 1	3276	NM_198319.2	0.067974089	−0.493547647	0.493547647	0.001211268	0.1787
116	4180142	KIAA1370	KIAA1370	56204	NM_019600.1	−0.224639294	0.492945505	0.492945505	0.001230739	0.18
117	6860148	SLC9A6	“solute carrier family 9	10479	NM_001042537.1	−0.17456976	0.491943559	0.491943559	0.001263753	0.1827
			(sodium/hydrogen exchanger),
			member 6”
118	1990487	XRN1	5′-3′ exoribonuclease 1	54464	NM_019001.2	−0.23813416	0.491542716	0.491542716	0.001277179	0.1827
119	1230270	WTIP	Wilms tumor 1 interacting protein	126374	XM_059037.7	0.07763865	−0.49141535	0.49141535	0.001281471	0.1827
120	7510164	SCAMP5	secretory carrier membrane protein 5	192683	NM_138967.2	0.0812625	−0.490826456	0.490826456	0.001301484	0.183
121	4760243	NULL	NULL	646210	XR_016923.1	−0.404442095	0.490196486	0.490196486	0.001323199	0.183
122	3290689	C14orf166	chromosome 14 open reading frame	51637	NM_016039.1	−0.321385016	0.490154831	0.490154831	0.001324646	0.183
			166
123	3780469	SMARCA5	“SWI/SNF related, matrix	8467	NM_003601.2	−0.115124978	0.489947033	0.489947033	0.001331886	0.183
			associated, actin dependent
			regulator of chromatin, subfamily a,
124	730373	LOC388621	—	388621	XM_941195.2	−0.448108038	0.48978157	0.48978157	0.001337675	0.183
125	3990561	LV6H	“lymphocyte antigen 6 complex,	4062	NM_002347.2	0.197994096	−0.48850596	0.48850596	0.001383063	0.1843
			locus H”
126	6760326	ZNF658	zinc finger protein 658	26149	NM_033160.4	−0.078993442	0.487877369	0.487877369	0.001405927	0.1843
127	2340091	NULL	NULL	646135	XM_933437.1	0.111295385	−0.487712861	0.487712861	0.001411965	0.1843
128	4220114	NULL	NULL	NULL	DA160411	0.070349309	−0.487568568	0.487568568	0.00141728	0.1843
129	5910131	PDE6H	“phosphodiesterase 6H, cGMP-	5149	NM_006205.1	0.060610886	−0.487328442	0.487328442	0.001426165	0.1843
			specific, cone, gamma”
130	4610138	CAPZA1	“capping protein (actin filament)	829	NM_006135.1	−0.36644329	0.487145738	0.487145738	0.001432958	0.1843
			muscle Z-line, alpha 1”
131	160537	KDSR	3-ketodihydrosphingosine	2531	NM_002035.1	−0.165230376	0.487124003	0.487124003	0.001433768	0.1843
			reductase
132	4540138	NGB	neuroglobin	58157	NM_021257.3	0.062540263	−0.487061726	0.487061726	0.001436091	0.1843
133	3440670	NULL	NULL	402251	XM_377933.3	−0.279019599	0.48643729	0.48643729	0.00145957	0.1843
134	2000162	C5orf20	chromosome 5 open reading frame	140947	NM_130848.2	0.086688645	−0.486295653	0.486295653	0.001464943	0.1843
			20
135	520215	UBE2V1	ubiquitin-conjugating enzyme E2	7335	NM_001032288.1	0.104438712	−0.48626056	0.48626056	0.001466277	0.1843
			variant 1
136	4150553	TAF13	“TAF13 RNA polymerase II, TATA	6884	NM_005645.3	0.061312413	−0.485315546	0.485315546	0.001502601	0.1857
			box binding protein (TBP)-
			associated factor, 18 kDa”
137	4640739	NULL	NULL	NULL	AL120241	−0.069719279	0.485027915	0.485027915	0.001513814	0.1857
138	60053	RPL11	ribosomal protein L11	6135	NM_000975.2	−0.156372832	0.484070445	0.484070445	0.001551674	0.1857
139	6180463	CNNM3	cyclin M3	26505	NM_017623.4	0.168754951	−0.484039615	0.484039615	0.001552907	0.1857
140	2710020	NULL	NULL	NULL	BX093329	0.068337239	−0.483771626	0.483771626	0.00156366	0.1857
141	1090692	GPBP1	GC-rich promoter binding protein 1	65056	NM_022913.1	−0.264875927	0.483664554	0.483664554	0.001567975	0.1857
142	5360719	MAPK9	mitogen-activated protein kinase 9	5601	NM_002752.3	−0.123212945	0.483410076	0.483410076	0.001578271	0.1857
143	7550066	MERTK	c-mer proto-oncogene tyrosine	10461	NM_006343.2	0.178168499	−0.483308071	0.483308071	0.001582415	0.1857
			kinase
144	1980628	SMARCA5	“SWI/SNF related, matrix	8467	NM_003601.2	−0.146115776	0.483245604	0.483245604	0.001584958	0.1857
			associated, actin dependent
			regulator of chromatin, subfamily a,
145	6980253	PTPLB	“protein tyrosine phosphatase-like	201562	NM_198402.2	−0.336175973	0.483199931	0.483199931	0.001586819	0.1857
			(proline instead of catalytic
			arginine), member b”
146	5560465	NOP56	NOP56 ribonucleoprotein homolog	10528	NM_006392.2	−0.266935568	0.482908033	0.482908033	0.00159876	0.1858
			(yeast)
147	730288	COG3	component of oligomeric golgi	83548	NM_031431.2	−0.128112796	0.482057164	0.482057164	0.001634022	0.1881
			complex 3
148	6110747	GIMAP2	“GTPase, IMAP family member 2”	26157	NM_015660.2	−0.45531031	0.481664524	0.481664524	0.001850524	0.1881
149	1500201	HNRNPC	heterogeneous nuclear	3183	NM_031314.1	−0.397999182	0.481642829	0.481642829	0.00165144	0.1881
			ribonucleoprotein C (C1/C2)
150	1570491	hCG_2015956	—	648000	XM_371757.5	−0.31840088	0.481241081	0.481241081	0.001668486	0.1887
151	4540356	UFM1	ubiquitin-fold modifier 1	51569	NM_016617.1	−0.290998607	0.480702355	0.480702355	0.001691587	0.1901
152	7000474	GARNL1	GTPase activating Rap/RanGAP	253959	NM_194301.2	−0.175348366	0.480353096	0.480353096	0.001706713	0.1905
			domain-like 1
153	7380382	RNF115	ring finger protein 115	27246	NM_014455.1	0.278371033	−0.479876191	0.479876191	0.001727561	0.1916
154	3060040	PABPC1	“poly(A) binding protein,	26986	NM_002568.3	−0.393451244	0.479514498	0.479514498	0.001743522	0.1919
			cytoplasmic 1”
155	2570132	CLEC2D	“C-type lectin domain family 2,	29121	NM_001004419.2	−0.163087579	0.479273474	0.479273474	0.00175423	0.1919
			member D”
156	5900731	SFRS12	“splicing factor, arginine/serine-	140890	NM_001077199.1	−0.290167988	0.47882202	0.47882202	0.001774443	0.1919
			rich 12”
157	2360754	LSM14B	“LSM14B, SCD6 homolog B	149986	NM_144703.2	0.096185097	−0.47854662	0.47854662	0.001786874	0.1919
			(S. cerevisiae)”
158	840403	TSPAN17	tetraspanin 17	26262	NM_130465.3	0.154915647	−0.478510302	0.478510302	0.001788519	0.1919
159	3990564	CCDC89	coiled-coil domain containing 89	220388	NM_152723.1	0.204429972	−0.478138699	0.478138699	0.001805428	0.1919
160	1990093	NULL	NULL	NULL	BC042493	0.047968793	−0.477656393	0.477656393	0.001827585	0.1919
161	3990441	ABCC13	“ATP-binding cassette. sub-family	150000	NR_003087.1	0.143883548	−0.477586579	0.477586579	0.001830812	0.1919
			C (CFTR/MRP), member 13”
162	6940433	STAT5B	signal transducer and activator of	6777	NM_012448.3	−0.24015242	0.477561066	0.477561066	0.001831992	0.1919
			transcription 5B
163	6060553	RBP5	“retinol binding protein 5, cellular”	83758	NM_031491.1	0.051243739	−0.47707584	0.47707584	0.001854572	0.1924
164	770021	PRKRA	“protein kinase, interferon-inducible	8575	NM_003690.3	−0.229357783	0.476977269	0.476977269	0.001859189	0.1924
			double stranded RNA dependant
			activator”
165	2360630	FDFT1	farnesyl-diphosphate	2222	NM_004462.3	−0.242595956	0.476367672	0.476367672	0.001887967	0.1942
			farnesyltransferase 1
166	5570161	KCNJ14	“potassium inwardly-rectifying	3770	NM_170720.1	0.076087153	−0.475749323	0.475749323	0.001917559	0.1947
			channel, subfamily J, member 14”
167	3120762	MSH5	mutS homolog 5 (E. coli)	4438	NM_002441.3	0.058093161	−0.475672606	0.475672606	0.001921258	0.1947
168	6280747	NULL	NULL	643240	XM_926602.1	0.057101502	−0.475541877	0.475541877	0.001927577	0.1947
169	4780767	FLJ40473	—	285226	XR_001031.1	−0.068012051	0.474724843	0.474724843	0.001967486	0.1968
170	290632	NULL	NULL	NULL	DB337375	0.05951249	−0.474639429	0.474639429	0.001971699	0.1968
171	3360100	IDH3A	isocitrate dehydrogenase 3 (NAD+)	3419	NM_005530.2	−0.146008756	0.474175832	0.474175832	0.001994708	0.1979
			alpha
172	7150270	LRRC26	leucine rich repeat containing 26	389816	NM_001013653.2	0.105999587	−0.472964535	0.472964535	0.00205595	0.2028
173	7610113	SLC26A8	“solute carrier family 26, member	116369	NM_138718.1	0.063661004	−0.472306817	0.472306817	0.002089891	0.2028
			B”
174	6650646	C4orf39	chromosome 4 open reading frame	152756	NM_153027.1	−0.056865183	0.472186172	0.472186172	0.00209617	0.2028
			39
175	3390309	FAM74A4	“family with sequence similarity 74,	401508	NM_207507.1	0.052989269	−0.471884728	0.471884728	0.002111932	0.2028
			member A4”
176	5860327	PRPF1B	PRP18 pre-mRNA processing	8559	NM_003675.3	−0.26670234	0.471782594	0.471782594	0.002117296	0.2028
			factor 18 homolog (S. cerevisiae)
177	1090367	BIVM	“basic, immunoglobulin-like variable	54841	NM_017693.2	−0.126644305	0.471623506	0.471623506	0.002125674	0.2028
			motif containing”
178	2570725	PPCS	phosphopantothenoylcysteine	79717	NM_001077447.1	−0.310167811	0.471401485	0.471401485	0.002137416	0.2028
			synthetase
179	8110091	WSB1	WD repeat and SOCS box-	26118	NM_134265.2	−0.29256262	0.471357938	0.471357938	0.002139726	0.2028
			containing 1
180	1110102	HS2ST1	heparan sulfate 2-O-	9853	NM_012262.2	−0.075582168	0.470862477	0.470862477	0.002186161	0.2033
			sulfotransferase 1
181	4010452	SLC38A6	“solute carrier family 38, member	145389	NM_153811.1	−0.130358094	0.470802009	0.470802009	0.002169407	0.2033
			6”
182	3130543	RNASE3	“ribonuclease, RNase A family, 3	6037	NM_002935.2	0.573752609	−0.470400954	0.470400954	0.002191043	0.2033
			(eosinophil cationic protein)”
183	4180709	SPAG5	sperm associated antigen 5	10615	NM_006461.3	0.043518097	−0.470381365	0.470381365	0.002192104	0.2033
184	2340601	AMMECR1	“Alport syndrome, mental	9949	NM_015365.2	−0.137410703	0.469981776	0.469981776	0.002213859	0.2042
			retardation, midface hypoplasia and
			elliptocytosis chromosomal region
185	5870326	SLC2A8	“solute carrier family 2 (facilitated	29988	NM_014580.3	0.183791974	−0.468266194	0.468266194	0.002309432	0.2118
			glucose transporter), member 8”
186	610367	HECA	headcase homolog (Drosophila)	51696	NM_016217.2	−0.312188865	0.467582354	0.467582354	0.002348527	0.2142
187	6510619	NAE1	NEDD8 activating enzyme E1	8883	NM_001018160.1	−0.29276015	0.467293313	0.467293313	0.002365226	0.2146
			subunit 1
188	6100170	NULL	NULL	NULL	AI004472	0.074355718	−0.466767709	0.466767709	0.002395858	0.2155
189	2570358	HNRPDL	heterogeneous nuclear	9987	NM_031372.1	−0.382998221	0.46668552	0.46668552	0.00240068	0.2155
			ribonucleoprotein D-like
190	1690600	FAM53B	“family with sequence similarity 53,	9679	NM_014661.3	0.082502036	−0.465522685	0.465522685	0.002469813	0.2204
			member B”
191	2230538	LRRN3	leucine rich repeat neuronal 3	54674	NM_001099660.1	−0.625504431	0.465045112	0.465045112	0.002498708	0.2204
192	4610519	NULL	NULL	NULL	BU753725	0.072652165	−0.464655359	0.464655359	0.002522509	0.2204
193	6200593	CCDC15	coiled-coil domain containing 15	80071	NM_025004.2	−0.055337923	0.464591132	0.464591132	0.002526451	0.2204
194	1580286	SEH1L	SEH1-like (S. cerevisiae)	81929	NM_031216.3	−0.083010039	0.464510779	0.464510779	0.002531389	0.2204
195	5050402	HIST1H2BK	“histone cluster 1, H2bk”	85236	NM_080593.1	0.379454337	−0.464481722	0.464481722	0.002533177	0.2204
196	1850300	TC2N	“tandem C2 domains, nuclear”	123036	NM_152332.3	−0.236871126	0.463622849	0.463622849	0.002586527	0.2232
197	3610376	NULL	NULL	NULL	BM717102	0.080470357	−0.463547722	0.463547722	0.00259124	0.2232
198	7400377	CEACAM6	carcinoembryonic antigen-related	4680	NM_002483.3	0.588920001	−0.462719693	0.462719693	0.002643687	0.2266
			cell adhesion molecule 6 (non-
			specific cross reacting antigen)
199	2030477	OTP	orthopedia homeobox	23440	NM_032109.2	0.058004572	−0.462346154	0.462346154	0.002667651	0.2271
200	3360215	NULL	NULL	NULL	BQ183460	0.053186883	−0.462195315	0.462195315	0.002677381	0.2271
201	6420730	RPL9	ribosomal protein L9	6133	NM_001024921.2	−0.56653985	0.462002078	0.462002078	0.002689892	0.2271
202	3780670	NGLY1	N-glycanase 1	55768	NM_018297.2	−0.197659111	0.46152437	0.46152437	0.002721041	0.2279
203	1230593	SP3	Sp3 transcription factor	6670	NM_001017371.3	−0.175703429	0.461118519	0.461118519	0.002747753	0.2279
204	5900128	NULL	NULL	391817	XM_936708.1	−0.044221454	0.461068597	0.461068597	0.002751055	0.2279
205	7400376	RABL2A	“RAB, member of RAS oncogene	11159	NM_013412.1	−0.178370764	0.460558719	0.460558719	0.002784974	0.2279
			family-like 2A”
206	6380768	EIF4E	eukaryotic translation initiation	1977	NM_001968.2	−0.084050702	0.460244198	0.460244198	0.00280608	0.2279
			factor 4E
207	5310747	PSIP1	PC4 and SFRS1 interacting protein 1	11168	NM_033222.2	−0.298779917	0.460104407	0.460104407	0.002815505	0.2279
208	110195	LOC646197	—	646197	XM_929153.1	−0.239784184	0.459988242	0.459988242	0.002823359	0.2279
209	7380068	CNBP	“CCHC-type zinc finger, nucleic	7555	NM_003418.1	−0.327720874	0.45994846	0.45994846	0.002826053	0.2279
			acid binding protein”
210	6020575	NNT	nicotinamide nucleotide	23530	NM_012343.3	−0.191702435	0.459704691	0.459704691	0.00284261	0.2279
			transhydrogenase
211	3180438	RPS3A	ribosomal protein S3A	6189	NM_001006.3	−0.215689394	0.459396504	0.459396504	0.002863663	0.2279
212	6590441	TRIP12	thyroid hormone receptor interactor	9320	NM_004238.1	−0.196624966	0.459371285	0.459371285	0.002865392	0.2279
			12
213	4150408	P2RY2	“purinergic receptor P2Y, G-protein	5029	NM_002564.2	0.182075591	−0.459094109	0.459094109	0.002884454	0.2279
			coupled, 2”
214	6020598	PMAIP1	phorbol-12-myristate-13-acetate-	5366	NM_021127.1	−0.206408928	0.458725976	0.458725976	0.002909942	0.2279
			induced protein 1
215	3780382	DKFZp761E198	—	91056	NM_138368.3	0.361999782	−0.458706675	0.458706675	0.002911284	0.2279
216	4570008	EXOG	“endo/exonuclease (5′-3′),	9941	NM_005107.2	0.223001865	−0.458501321	0.458501321	0.002925593	0.2279
			endonuclease G-like”
217	7550341	HIGD1A	“HIG1 domain family, member 1A”	25994	NM_014056.1	−0.279289648	0.458461556	0.458461556	0.002928371	0.2279
218	2640551	CMPK1	“cytidine monophosphate (UMP-	51727	NM_016308.1	−0.272595837	0.458061071	0.458061071	0.002956478	0.2279
			CMP) kinase 1, cytosolic”
219	1010315	LINS1	lines homolog 1 (Drosophila)	55180	NM_001040614.1	−0.286168405	0.458036973	0.458036973	0.002958177	0.2279
220	870040	ASCC3	activating signal cointegrator 1	10973	NM_006828.2	−0.10465835	0.457844382	0.457844382	0.002971785	0.2279
			complex subunit 3
221	5820202	LOC644131	—	644131	XR_018325.1	−0.244724622	0.457679581	0.457679581	0.002983472	0.2279
222	130670	ZDHHC5	“zinc finger, DHHC-type containing	25921	NM_015457.2	0.193270447	−0.457640394	0.457640394	0.002986257	0.2279
			5”
223	2370754	G3BP2	GTPase activating protein (SH3	9908	NM_012297.3	0.055347977	−0.457521539	0.457521539	0.002994718	0.2279
			domain) binding protein 2
224	6250615	PGLYRP1	peptidoglycan recognition protein 1	8993	NM_005091.1	0.663365274	−0.456858765	0.456858765	0.003042283	0.2305
225	6450538	TCERG1	transcription elongation regulator 1	10915	NM_006706.3	−0.153163323	0.455894063	0.455894063	0.003112699	0.2315
226	4200022	MIRHG1	microRNA host gene 1 (non-protein	407975	XM_931088.1	−0.087998961	0.455880766	0.455880766	0.003113679	0.2315
			coding)
227	6510441	NULL	NULL	NULL	AW337309	0.053375479	−0.455703686	0.455703686	0.003126762	0.2315
228	1990132	USH1G	Usher syndrome 1G (autosomal	124590	NM_173477.2	0.052441261	−0.455661664	0.455661664	0.003129874	0.2315
			recessive)
229	3800647	UGCG	UDP-glucose ceramide	7357	NM_003358.1	0.348634208	−0.455608899	0.455608899	0.003133785	0.2315
			glucosyltransferase
230	8900044	AMN1	antagonist of mitotic exit network 1	196394	NM_207337.1	−0.126543905	0.45510482	0.45510482	0.003171363	0.2315
			homolog (S. cerevisiae)
231	4560270	PTPLB	“protein tyrosine phosphatase-like	201582	NM_198402.2	−0.266540406	0.455059166	0.455059166	0.003174786	0.2315
			(proline instead of catalytic
			arginine), member b”
232	3710681	ARFGEF1	ADP-ribosylation factor guanine	10565	NM_006421.3	−0.094839399	0.454851268	0.454851268	0.003190414	0.2315
			nucleotide-exchange factor
			1(brefeldin A-inhibited)
233	4540689	ANKRD10	ankyrin repeat domain 10	55608	NM_017664.2	−0.170575575	0.454839609	0.454839609	0.003191293	0.2315
234	4860762	INPP4B	“inositol polyphosphate-4-	8821	NM_003866.1	−0.281061337	0.454820734	0.454820734	0.003192715	0.2315
			phosphatase, type II, 105 kDa”
235	2320594	NULL	NULL	NULL	BX119501	0.089280604	−0.454390975	0.454390975	0.003225254	0.2325
236	5690403	NULL	NULL	645550	XM_928570.1	−0.065705517	0.454284141	0.454284141	0.003233388	0.2325
237	3710682	NULL	NULL	642033	XM_936103.1	0.143366073	−0.453895065	0.453895065	0.003263162	0.2336
238	7570189	GAGE6	G antigen 6	2578	NM_001476.1	0.084017945	−0.453062273	0.453062273	0.003327698	0.2372
239	2120468	C10orf58	chromosome 10 open reading frame	84293	NM_032333.2	−0.327354271	0.451962933	0.451962933	0.003414595	0.2389
			58
240	1410170	GOPC	golgi associated PDZ and coiled-	57120	NM_020399.2	−0.088182858	0.45162816	0.45162816	0.003441448	0.2389
			coil motif containing
241	3420068	HAT1	histone acetyltransferase 1	8520	NM_003642.2	−0.268653366	0.451449886	0.451449886	0.003455823	0.2389
242	4590349	ACVR2A	“activin A receptor, type IIA”	92	NM_001616.3	−0.105208688	0.45133743	0.45133743	0.003464917	0.2389
243	3370673	GUSBL2	“glucuronidase, beta-like 2”	375513	NM_206910.1	0.128073825	−0.451300153	0.451300153	0.003467937	0.2389
244	2640255	NULL	NULL	641848	XM_935588.1	−0.645965338	0.45124504	0.45124504	0.003472405	0.2389
245	5960332	SLC39A10	“solute carrier family 39 (zinc	57181	NM_020342.1	−0.147299889	0.451151515	0.451151515	0.003479999	0.2389
			transporter), member 10”
246	4120056	IQSEC2	IQ motif and Sec7 domain 2	23096	NM_015075.1	0.077724109	−0.450780113	0.450780113	0.003510299	0.2389
247	5820392	CCT6A	“chaperonin containing TCP1,	908	NM_001009186.1	−0.24460782	0.450747413	0.450747413	0.003512977	0.2389
			subunit 6A (zeta 1)”
248	2570112	ABLIM1	actin binding LIM protein 1	3983	NM_006720.3	−0.4799407	0.450454564	0.450454564	0.003537047	0.2389
249	2710735	RASD1	“RAS, dexamethasone-induced 1”	51655	NM_016084.3	0.176270502	−0.450334284	0.450334284	0.003546974	0.2389
250	3390047	FREM2	FRAS1 related extracellular matrix	341640	NM_207361.4	0.062120756	−0.450220577	0.450220577	0.003556381	0.2389
			protein 2
251	2900039	XRCC5	X-ray repair complementing	7520	NM_021141.2	−0.210035123	0.450062106	0.450062106	0.003569529	0.2389
			defective repair in Chinese hamster
			cells 5 (double-strand-break
252	8550600	MYC	v-mye myelocytomatosis viral	4609	NM_002467.3	−0.337363684	0.450052467	0.450052467	0.00357033	0.2389
			oncogene homolog (avian)
253	7400343	STX2	syntaxin 2	2054	NM_001980.2	−0.258793675	0.449998887	0.449998887	0.003574785	0.2389
254	2190390	NCOA1	nuclear receptor coactivator 1	8648	NM_147223.2	−0.208822548	0.449989658	0.449989658	0.003575553	0.2389
255	3710465	C6orf211	chromosome 6 open reading frame	79624	NM_024573.1	−0.114858487	0.449508458	0.449508458	0.003615794	0.2397
			211
256	6620356	ARPP-19	—	10776	NM_006628.4	−0.261668585	0.449498501	0.449498501	0.003616631	0.2397
257	5900100	BCR	breakpoint cluster region	613	NM_021574.2	0.074331836	−0.449183958	0.449183958	0.003643153	0.2398
258	5360204	NMD3	NMD3 homolog (S. cerevisiae)	51068	NM_015938.3	−0.201253758	0.449147407	0.449147407	0.003646246	0.2398
259	7320615	NULL	NULL	NULL	DR731427	0.097655571	−0.448768392	0.448768392	0.003678454	0.241
260	1070475	RPL11	ribosomal protein L11	6135	NM_000975.2	−0.145832491	0.448285553	0.448285553	0.003719844	0.2419
261	1430477	CTSL2	cathepsin L2	1515	NM_001333.2	0.048311832	−0.448097229	0.448097229	0.003736097	0.2419
262	6580609	CNOT8	“CCR4-NOT transcription complex,	9337	NM_004779.4	−0.206326635	0.448051554	0.448051554	0.003740048	0.2419
			subunit 8”
263	430100	XRCC6	X-ray repair complementing	2547	NM_001469.3	−0.202101353	0.447948393	0.447948393	0.003748986	0.2419
			defective repair in Chinese hamster
			cells 6
264	7150685	CBX5	“chromobox homolog 5 (HP1 alpha	23468	NM_012117.1	0.077258047	−0.447723533	0.447723533	0.003768532	0.2422
			homolog, Drosophila)”
265	460682	CCDC132	coiled-coil domain containing 132	55610	NM_017667.2	−0.123015026	0.447052981	0.447052981	0.003827349	0.2429
266	160047	LOC389787	—	389787	XM_497072.2	−0.49206406	0.446705007	0.446705007	0.003658186	0.2429
267	2900255	ZBTB45	zinc finger and BTB domain	84878	NM_032792.2	0.124641218	−0.446554684	0.446554684	0.003871574	0.2429
			containing 45
268	5360168	NULL	NULL	652324	XM_941748.1	−0.08742157	0.446262544	0.446262544	0.003897708	0.2429
269	4390398	LCN2	lipocalin 2	3934	NM_005564.3	0.939054288	−0.446256107	0.446256107	0.003898286	0.2429
270	6620402	NUDT16	nudix (nucleoside diphosphate	131870	NM_152395.1	0.177581106	−0.446234853	0.446234853	0.003900194	0.2429
			linked moiety X)-type motif 16
271	5900482	HMGB2	high-mobility group box 2	3148	NM_002129.2	−0.440289057	0.446075441	0.446075441	0.003914527	0.2429
272	1740709	NULL	NULL	NULL	CB052724	0.070777262	−0.446031691	0.448031691	0.003918469	0.2429
273	5310736	FAM162A	“family with sequence similarity	26355	NM_014367.3	−0.324511803	0.445941038	0.445941038	0.003926647	0.2429
			162, member A”
274	770128	L3MBTL3	f(3)mbt-like 3 (Drosophila)	84456	NM_032438.1	−0.161561418	0.445836872	0.445836872	0.003936064	0.2429
275	7320022	NULL	NULL	NULL	AL832228	0.086273286	−0.445654736	0.445654736	0.003952575	0.2429
276	6980328	ANP32C	“acidic (Jeucine-rich) nuclear	23520	NM_012403.1	−0.074417224	0.445406089	0.445406089	0.003975214	0.2429
			phosphoprotein 32 family, member
			C”
277	510050	LOC652837	—	652837	XM_942529.1	−0.036184103	0.445136212	0.445136212	0.003999913	0.2429
278	1300746	NULL	NULL	647971	XM_937029.2	0.038761564	−0.44462162	0.44462162	0.004047379	0.2429
279	5910241	ZBBX	“zinc finger, B-box domain	79740	NM_024687.2	0.067673114	−0.444458165	0.444458165	0.004062559	0.2429
			containing”
280	4860066	NULL	NULL	647346	XM_936495.2	−0.209955699	0.44434344	0.44434344	0.004073242	0.2429
281	5220204	C19orf66	chromosome 19 open reading frame	55337	NM_018381.2	0.15331761	−0.444184486	0.444184486	0.004088085	0.2429
			66
282	6480600	THUMPD1	THUMP domain containing 1	55623	NM_017736.3	−0.123219301	0.444044022	0.444044022	0.004101241	0.2429
283	5390433	DICER1	“dicer 1, ribonuclease type III”	23405	NM_030621.2	−0.111116126	0.443842864	0.443842864	0.004120145	0.2429
284	2570020	CTR9	“Ctr9. Paf1/RNA polymerase II	9646	NM_014633.3	−0.109638771	0.443761854	0.443761854	0.004127779	0.2429
			complex component, homolog
			(S. cerevisiae)”
285	50563	DOK7	docking protein 7	285489	NM_173660.3	0.047906163	−0.443751623	0.443751623	0.004128744	0.2429
286	6380747	ANKRD32	ankyrin repeat domain 32	84250	NM_032290.2	−0.104537188	0.443725202	0.443725202	0.004131237	0.2429
287	5310270	GALNT14	UDP-N-acetyl-alpha-D-	79623	NM_024572.2	0.073549787	−0.443580709	0.443580709	0.004144895	0.2429
			galactosamine:polypeptide N-
			acetylgalactosaminyltransferase 14
288	2900445	IQGAP3	IQ motif containing GTPase	128239	NM_178229.3	−0.047779237	0.443165428	0.443165428	0.004184367	0.2429
			activating protein 3
289	4250048	CMTM7	CKLF-like MARVEL transmembrane	112616	NM_138410.2	0.263133293	−0.44312946	0.44312946	0.004187801	0.2429
			domain containing 7
290	3940358	OSBPL8	oxysterol binding protein-like 8	114882	NM_001003712.1	−0.261246813	0.443098374	0.443098374	0.004190771	0.2429
291	2450487	KLRG2	“killer cell lectin-like receptor	346689	NM_198508.2	0.048222142	−0.443079336	0.443079336	0.004192591	0.2429
			subfamily G, member 2”
292	6420309	FAM134B	“family with sequence similarity	54463	NM_001034850.1	−0.358481173	0.442988596	0.442988596	0.004201274	0.2429
			134, member B”
293	4900343	MORF4L1	mortality factor 4 like 1	10933	NM_206839.1	−0.24904666	0.442917936	0.442917936	0.004208046	0.2429
294	1570292	NULL	NULL	NULL	AI807878	−0.087151047	0.442699765	0.442699765	0.004229016	0.2429
295	7650669	TBC1D4	“TBC1 domain family, member 4”	9882	NM_014832.2	−0.247692111	0.44262335	0.44262335	0.004236383	0.2429
296	2760553	UBA3	ubiquitin-like modifier activating	9039	NM_198197.1	−0.187898967	0.442606739	0.442606739	0.004237986	0.2429
			enzyme 3
297	4670605	MGC40489	—	146880	XR_016048.1	−0.029223716	0.442250835	0.442250835	0.004272453	0.2437
298	3460132	PAQR4	progestin and adipoQ receptor	124222	NM_152341.2	0.236239034	−0.442151094	0.442151094	0.004282157	0.2437
			family member IV
299	6200747	LOC220433	—	220433	XM_941684.2	−0.448374765	0.442031781	0.442031781	0.004293789	0.2437
300	4120438	RABGGTA	“Rab geranylgeranyltransferase,	5875	NM_182836.1	0.121605116	−0.441511876	0.441511876	0.004344798	0.2448
			alpha subunit”
indicates data missing or illegible when filed

TABLE 2
List of top 300 genes selected by Limma.
Limma
No.	Name of gene	Description of gene	EntrezID	Acc	limma_logFC	AveExpr	limma_t	limma_pvalue	limma_adjpvalue
1	HIST1H2BK	“histone cluster 1, H2bk”	85236	NM_080593.1	0.379122401	10.56860754	4.621075111	3.96E−05	0.194083013
2	LDHB	lactate dehydrogenase B	3945	NM_002300.4	−0.605485777	11.14389182	−4.582736357	4.47E−05	0.194083013
3	DPP4	dipeptidyl-peptidase 4	1803	NM_001935.3	−0.307400655	7.025297744	−4.581722797	4.48E−05	0.194083013
4	PCDHGB6	“protocadherin gamma subfamily B,	56100	NM_018926.2	0.176789549	6.795139553	4.467413408	6.40E−05	0.194083013
		6”
5	PTPN18	“protein tyrosine phosphatase,	26469	NM_014369.2	0.083763446	6.656468326	4.431096493	7.16E−05	0.194083013
		non-receptor type 18 (brain-
		derived)”
6	P2RY2	“purinergic receptor P2Y, G-protein	5029	NM_002564.2	0.182075591	6.769555976	4.414689685	7.54E−05	0.194083013
		coupled, 2”
7	MAN2A1	“mannosidase, alpha, class 2A,	4124	NM_002372.2	−0.327379686	8.689610458	−4.395157644	8.01E−05	0.194083013
		member 1”
8	ZNF83	zinc finger protein 83	55769	NM_018300.2	−0.30567958	7.621524008	−4.252369567	0.000124289	0.248550702
9	PTGES3	prostaglandin E synthase 3	10728	NM_006601.4	−0.528677962	8.635339	−4.175586605	0.000157174	0.248550702
		(cytosolic)
10	ZBTB20	zinc finger and BTB domain	26137	NM_015642.3	−0.287117754	7.696970778	−4.105392785	0.000194573	0.248550702
		containing 20
11	TUSC2	tumor suppressor candidate 2	11334	NM_007275.1	0.162628207	7.290633004	4.10064263	0.000197396	0.248550702
12	P4HA1	“prolyl 4-hydroxylase, alpha	5033	NM_000917.2	−0.307837835	8.037416362	−4.091284705	0.000203075	0.248550702
		polypeptide 1”
13	PDP2	—	57546	NM_020786.1	0.068777448	6.597619521	4.058263335	0.000224413	0.248550702
14	C7orf28A	chromosome 7 open reading frame	51622	XM_001133729.1	−0.383441629	7.951155828	−4.03783508	0.000238691	0.248550702
		28A
15	USP9Y	“ubiquitin specific peptidase 9, Y-	8287	NM_004654.3	−0.094524102	6.676560456	−4.036753411	0.000239471	0.248550702
		linked (fat facets-like, Drosophila)”
16	DFFA	“DNA fragmentation factor, 45 kDa,	1676	NM_213566.1	0.121909434	6.810258539	4.008160095	0.000261017	0.248550702
		alpha polypeptide”
17	NAIP	“NLR family, apoptosis inhibitory	4671	NM_004536.2	0.073560957	6.62992199	3.957213679	0.000304171	0.248550702
		protein”
18	MBNL1	muscleblind-like (Drosophila)	4154	NM_207295.1	−0.320695796	9.005728482	−3.947528218	0.000313125	0.248550702
19	CPT1A	carnitine palmitoyltransferase 1A	1374	NM_001031847.1	0.165571989	6.885159727	3.947282501	0.000313355	0.248550702
		(liver)
20	TIAL1	TIA1 cytotoxic granule-associated	7073	NM_001033925.1	−0.233908998	7.770315033	−3.945464543	0.000315066	0.248550702
		RNA binding protein-like 1
21	ZBTB45	zinc finger and BTB domain	84878	NM_032792.2	0.124641218	6.816614376	3.938104816	0.000322082	0.248550702
		containing 45
22	DDX17	DEAD (Asp-Glu-Ala-Asp) box	10521	NM_030881.2	−0.443292451	8.856378817	−3.877227352	0.000386238	0.248550702
		polypeptide 17
23	LOC645489	—	645489	XM_928514.1	−0.199041088	7.339931356	−3.865849564	0.000399531	0.248550702
24	LOC643310	—	643310	XM_926656.1	−0.395581648	9.491360136	−3.862341614	0.000403718	0.248550702
25	CROP	—	51747	NM_006107.2	−0.443849065	8.126025421	−3.823023431	0.000453658	0.248550702
26	GP1BA	“glycoprotein Ib (platelet), alpha	2811	NM_000173.4	0.13089936	6.982468215	3.821325354	0.000455945	0.248550702
		polypeptide”
27	RIN1	Ras and Rab interactor 1	9610	NM_004292.2	0.132155916	6.826236745	3.815491484	0.000463885	0.248550702
28	HNRPA1L-2	—	664709	NR_002944.2	−0.432630765	9.53229527	−3.813682717	0.000466374	0.248550702
29	NULL	NULL	NULL	BY797688	−0.097047292	6.728704366	−3.798342261	0.000488009	0.248550702
30	NAP1L1	nucleosome assembly protein 1-like 1	4673	NM_139207.1	−0.357418466	7.704201529	−3.786307558	0.000505658	0.248550702
31	BUB3	budding uninhibited by	9184	NM_004725.2	−0.303162523	7.95184304	−3.766258332	0.000536441	0.248550702
		benzimidazoles 3 homolog (yeast)
32	BCAT1	“branched chain aminotransferase	586	NM_005504.4	0.161097122	6.846191463	3.760614109	0.000545429	0.248550702
		1, cytosolic”
33	CMPK1	“cytidine monophosphate (UMP-	51727	NM_016308.1	−0.398631213	8.439255099	−3.756013453	0.000552862	0.248550702
		CMP) kinase 1, cytosolic”
34	UBE4A	“ubiquitination factor E4A (UFD2	9354	NM_004788.2	−0.230502672	7.842924308	−3.753787092	0.000556494	0.248550702
		homolog, yeast)”
35	ALKBH4	“alkB, alkylation repair homolog 4	54784	NM_017621.2	0.120660698	6.880124992	3.743909631	0.000572889	0.248550702
		(E. coli)”
36	TSPAN17	tetraspanin 17	26262	NM_130465.3	0.154915647	7.039678231	3.741571832	0.000576837	0.248550702
37	AMY2A	“amylase, alpha 2A (pancreatic)”	279	NM_000699.2	−0.282794372	7.393714088	−3.736503685	0.000585487	0.248550702
38	IQSEC2	IQ motif and Sec7 domain 2	23096	NM_015075.1	0.077724109	6.596496017	3.736312891	0.000585815	0.248550702
39	UGP2	UDP-glucose pyrophosphorylase 2	7360	NM_006759.3	−0.347146055	8.140532242	−3.729235851	0.00059811	0.248550702
40	STAT5B	signal transducer and activator of	6777	NM_012448.3	−0.24015242	8.701273034	−3.715107247	0.000623404	0.248550702
		transcription 5B
41	IFNA10	“interferon, alpha 10”	3446	NM_002171.1	0.151388979	6.956915233	3.697947469	0.000655515	0.248550702
42	NULL	NULL	NULL	BX106581	0.112837902	6.659739953	3.696828765	0.000657663	0.248550702
43	TCP1	t-complex 1	6950	NM_030752.2	−0.256767834	8.217718732	−3.695651035	0.000659932	0.248550702
44	RASD1	“RAS, dexamethasone-induced 1”	51655	NM_016084.3	0.176270502	6.830608498	3.690572246	0.000669802	0.248550702
45	EXOSC10	exosome component 10	5394	NM_002685.2	−0.226165883	7.858330385	−3.680867853	0.000689058	0.248550702
46	LQK1	—	642946	XM_927142.1	0.072739876	6.577138215	3.676653685	0.000697586	0.248550702
47	NULL	NULL	646135	XM_933437.1	0.111295385	6.809297621	3.670589619	0.000710035	0.248550702
48	RPS20	ribosomal protein S20	6224	NM_001023.2	−0.162977591	14.67218734	−3.670408202	0.000710411	0.248550702
49	HP	haptoglobin	3240	NM_005143.2	0.40681683	7.165541368	3.666877322	0.000717762	0.248550702
50	ACTR3	ARP3 actin-related protein 3	10096	NM_005721.3	−0.459963089	8.761151473	−3.653066998	0.000747224	0.253578052
		homolog (yeast)
51	hCG_2015956	—	648000	XM_371757.5	−0.31840088	13.43073634	−3.643230911	0.000768915	0.255822595
52	C14orf166	chromosome 14 open reading frame	51637	NM_016039.1	−0.321385016	9.613544794	−3.613732377	0.000837664	0.26384555
		166
53	WSB1	WD repeat and SOCS box-	26118	NM_134265.2	−0.29256262	8.293125883	−3.612814725	0.000839894	0.26384555
		containing 1
54	CNNM3	cyclin M3	26505	NM_017623.4	0.168754951	7.079276404	3.609952443	0.000846889	0.26384555
55	KLHL7	kelch-like 7 (Drosophila)	55975	NM_001031710.1	−0.155913324	7.054179324	−3.605822463	0.000857081	0.26384555
56	SYNE1	“spectrin repeat containing, nuclear	23345	NM_182961.2	0.075512374	6.64747449	3.594518134	0.000885585	0.26384555
		envelope 1”
57	CDC16	cell division cycle 16 homolog (S. cerevisiae)	8881	NM_003903.3	−0.34380491	9.005265989	−3.594228701	0.000886327	0.26384555
58	ESRRAP2	estrogen-related receptor alpha	144832	NR_000033.2	0.169761171	6.944028851	3.578018474	0.000928831	0.268633114
		pseudogene 2
59	ZDHHC5	“zinc finger, DHHC-type containing	25921	NM_015457.2	0.193270447	7.893569537	3.57606895	0.000934073	0.268633114
		5”
60	FAM10A4	“family with sequence similarity 10,	145165	NR_002183.1	−0.370567771	9.471949409	−3.560823632	0.000976057	0.276028841
		member A4 pseudogene”
61	ELOVL5	“ELOVL family member 5,	60481	NM_021814.3	−0.284710319	8.617781544	−3.519828721	0.001098134	0.278705103
		elongation of long chain fatty acids
		(FEN1/Elo2, SUR4/Elo3-like,
62	LINS1	lines homolog 1 (Drosophila)	55180	NM_001040614.1	−0.286168405	7.802936078	−3.51832105	0.001102893	0.278705103
63	CCT6P1	“chaperonin containing TCP1,	643253	NR_003110.2	−0.281922881	8.987022794	−3.517147156	0.001106611	0.278705103
		subunit 6 (zeta) pseudogene 1”
64	GOLGA8C	“golgi autoantigen, golgin subfamily	400304	XM_375152.3	−0.242008817	6.988112539	−3.501558507	0.001157143	0.278705103
		a, 8C”
65	RPS3A	ribosomal protein S3A	6189	NM_001006.3	−0.215689394	13.27274226	−3.480011693	0.001230644	0.278705103
66	LRRC26	leucine rich repeat containing 26	389816	NM_001013653.2	0.105999587	6.599170468	3.476732331	0.001242216	0.278705103
67	SLC9A6	“solute carrier family 9	10479	NM_001042537.1	−0.17456976	8.079094525	−3.468474071	0.00127182	0.278705103
		(sodium/hydrogen exchanger),
		member 6”
68	NULL	NULL	648749	XM_937834.2	−0.061658345	6.590715595	−3.467954326	0.001273705	0.278705103
69	MPO	myeloperoxidase	4353	NM_000250.1	0.96554979	7.646263192	3.467107562	0.001276783	0.278705103
70	FDFT1	farnesyl-diphosphate	2222	NM_004462.3	−0.242595956	8.794891033	−3.459119586	0.00130617	0.278705103
		farnesyltransferase 1
71	NULL	NULL	NULL	U43604	0.301411554	7.199165409	3.453864806	0.001325853	0.278705103
72	IL21R	interleukin 21 receptor	50615	NM_181078.1	0.057079914	6.591538699	3.45178774	0.001333712	0.278705103
73	XRN1	5′-3′ exoribonuclease 1	54464	NM_019001.2	−0.23813416	8.508548219	−3.441864471	0.001371875	0.278705103
74	EXOG	“endo/exonuclease (5′-3′),	9941	NM_005107.2	0.223001865	7.264760612	3.441155154	0.001374642	0.278705103
		endonuclease G-like”
75	G3BP2	GTPase activating protein (SH3	9908	NM_012297.3	0.055347977	6.583384068	3.439083684	0.001382755	0.278705103
		domain) binding protein 2
76	MYC	v-myc myelocytomatosis viral	4609	NM_002467.3	−0.337363684	7.745340453	−3.43222232	0.001409956	0.278705103
		oncogene homolog (avian)
77	RPL11	ribosomal protein L11	6135	NM_000975.2	−0.156372832	14.69523285	−3.421668194	0.001452799	0.278705103
78	SLC2AB	“solute carrier family 2 (facilitated	29988	NM_014580.3	0.183791974	7.48215931	3.419438233	0.001462008	0.278705103
		glucose transporter), member 8”
79	THOC2	THO complex 2	57187	NM_001081550.1	0.168129085	6.922775737	3.418506601	0.001465873	0.278705103
80	NULL	NULL	NULL	AV730797	0.146406334	6.702252803	3.415196196	0.001479683	0.278705103
81	TNFRSF19	“tumor necrosis factor receptor	55504	NM_148957.2	0.070969941	6.600503679	3.412998956	0.001488918	0.278705103
		superfamily, member 19”
82	RNF115	ring finger protein 115	27246	NM_014455.1	0.278371033	8.827361643	3.410923159	0.001497693	0.278705103
83	LEF1	lymphoid enhancer-binding factor 1	51176	NM_016269.2	−0.599827856	9.374949765	−3.410373939	0.001500023	0.278705103
84	NELL2	NEL-like 2 (chicken)	4753	NM_006159.1	−0.537157632	8.635324105	−3.406582362	0.001516203	0.278705103
85	TUBE1	“tubulin, epsilon 1”	51175	NM_016262.3	−0.138726153	6.918780573	−3.405525994	0.00152074	0.278705103
86	GPBP1L1	GC-rich promoter binding protein	60313	NM_021639.3	−0.185092124	6.99451945	−3.40453954	0.001524989	0.278705103
		1-like 1
87	NULL	NULL	645609	XM_928619.1	0.215115706	6.93283128	3.402248419	0.001534902	0.278705103
88	RNF216L	ring finger protein 216-like	441191	XR_001271.1	0.162378967	7.075767146	3.391284261	0.001583195	0.278705103
89	LOC388621	—	388621	XM_941195.2	−0.448108038	12.6172039	−3.381059183	0.001629539	0.278705103
90	SNORA33	“small nucleolar RNA, H/ACA box	594839	NR_002436.1	−0.186113851	7.237748956	−3.378911416	0.001639437	0.278705103
		33”
91	FAM53B	“family with sequence similarity 53,	9679	NM_014661.3	0.082502036	6.720712848	3.378900914	0.001639485	0.278705103
		member B”
92	TCTEX1D1	Tctax1 domain containing 1	200132	NM_152665.1	0.124259481	6.947438013	3.378852115	0.001639711	0.278705103
93	CBX2	“chromobox homolog 2 (Pc class	84733	NM_005189.1	0.077041967	6.586068418	3.37584138	0.001653684	0.278705103
		homolog, Drosophila)”
94	SLC26A2	“solute carrier family 26 (sulfate	1836	NM_000112.3	0.078282552	6.63165789	3.374992231	0.001657646	0.278705103
		transporter), member 2”
95	TADA1L	“transcriptional adaptor 1 (HFI1	117143	NM_053053.2	−0.16203449	7.226654736	−3.373370577	0.001665237	0.278705103
		homolog, yeast)-like”
96	PTPLB	“protein tyrosine phosphatase-like	201562	NM_198402.2	−0.336175973	9.255647124	−3.373281148	0.001665656	0.278705103
		(proline instead of catalytic
		arginine), member b”
97	HNRNPC	heterogeneous nuclear	3183	NM_031314.1	−0.397999182	8.413292708	−3.361986141	0.001719468	0.278705103
		ribonucleoprotein C (C1/C2)
98	NULL	NULL	NULL	BF338665	0.061724508	6.594937826	3.36186306	0.001720063	0.278705103
99	NULL	NULL	731950	XR_016039.1	−0.061135983	6.603654541	−3.361179911	0.001723372	0.278705103
100	PKIA	“protein kinase (cAMP-dependent,	5569	NM_006823.2	−0.254561014	7.229052236	−3.360304127	0.001727622	0.278705103
		catalytic) inhibitor alpha”
101	PAQR4	progestin and adipoQ receptor	124222	NM_152341.2	0.235239034	7.212347489	3.360042242	0.001728895	0.278705103
		family member IV
102	ELA2	“elastase 2, neutrophil”	1991	NM_001972.2	1.319902836	8.282120812	3.357180559	0.001742862	0.278705103
103	ZNF276	zinc finger protein 276	92822	NM_152287.2	0.130599764	6.992968715	3.356571932	0.001745846	0.278705103
104	SLC26A8	“solute carrier family 26, member	116369	NM_138718.1	0.063661004	6.612090652	3.356315889	0.001747103	0.278705103
		8”
105	NULL	NULL	NULL	BM932227	−0.116682268	6.661300061	−3.347803068	0.00178939	0.278705103
106	HDAC2	histone deacetylase 2	3066	NM_001527.2	−0.308059644	9.194835902	−3.344717795	0.001804956	0.278705103
107	NULL	NULL	NULL	AA971450	0.072927449	6.644971089	3.340652054	0.001825665	0.278705103
108	HNRPDL	heterogeneous nuclear	9987	NM_031372.1	−0.382998221	8.609895867	−3.339735723	0.001830363	0.278705103
		ribonucleoprotein D-like
109	DSC1	desmocollin 1	1823	NM_004948.2	−0.247522067	6.842109462	−3.337976177	0.001839418	0.278705103
110	FAM134B	“family with sequence similarity	54463	NM_001034850.1	−0.358481173	7.824193291	−3.332078062	0.001870082	0.278705103
		134, member B”
111	NULL	NULL	NULL	AA431552	0.088033112	6.60564995	3.331235614	0.001874502	0.278705103
112	NOP56	NOP56 ribonucleoprotein homolog	10528	NM_006392.2	−0.266935568	7.752420168	−3.32920812	0.001885179	0.278705103
		(yeast)
113	SACM1L	SAC1 suppressor of actin	22908	NM_014016.2	−0.262966982	8.037968043	−3.320589417	0.001931216	0.278705103
		mutations 1-like (yeast)
114	C12orf43	chromosome 12 open reading frame	64897	NM_022895.1	−0.20852646	7.657143361	−3.318702024	0.00194144	0.278705103
		43
115	SMARCA5	“SWI/SNF related, matrix	8467	NM_003601.2	−0.115124978	7.082731596	−3.318505294	0.001942508	0.278705103
		associated, actin dependent
		regulator of chromatin, subfamily a.
116	GIMAP2	“GTPase, IMAP family member 2”	26157	NM_015660.2	−0.45531031	8.473264716	−3.316388313	0.001954043	0.278705103
117	NUDT16	nudix (nucleoside diphosphate	131870	NM_152395.1	0.177581106	7.017862529	3.314837959	0.001962531	0.278705103
		linked moiety X)-type motif 16
118	LRRN3	leucine rich repeat neuronal 3	54674	NM_018334.3	−0.383213794	6.977063895	−3.311837127	0.001979062	0.278705103
119	PRKCI	“protein kinase C, iota”	5584	NM_002740.5	−0.105841727	6.824866958	−3.311134682	0.00198295	0.278705103
120	RPL11	ribosomal protein L11	6135	NM_000975.2	−0.145832491	14.51015798	−3.31068699	0.001985432	0.278705103
121	NULL	NULL	NULL	AL120241	−0.069719279	6.594134665	−3.308246033	0.001999018	0.278705103
122	NULL	NULL	NULL	CX782759	−0.206252167	6.710163433	−3.305733304	0.002013095	0.278705103
123	AMN1	antagonist of mitotic exit network 1	196394	NM_207337.1	−0.126543905	6.727686827	−3.304450826	0.002020316	0.278705103
		homolog (S. cerevisiae)
124	FAM180B	“family with sequence similarity	399888	XM_941808.2	0.083819707	6.625010712	3.296734176	0.00206429	0.279340342
		180, member B”
125	HAT1	histone acetyltransferase 1	8520	NM_003642.2	−0.268653366	8.011690033	−3.295875016	0.002069242	0.279340342
126	NULL	NULL	649088	XM_938168.1	−0.257637488	6.821077074	−3.294997835	0.002074309	0.279340342
127	NULL	NULL	NULL	AL042883	0.08373784	6.721750094	3.288131695	0.002114385	0.280973338
128	SOX15	SRY (sex determining region Y)-box	6665	NM_006942.1	0.08255695	6.609101503	3.28725522	0.002119554	0.280973338
		15
129	NULL	NULL	649555	XM_945579.1	−0.269621337	8.007087043	−3.284266937	0.002137266	0.281124998
130	NULL	NULL	NULL	BF445990	0.102742584	6.676471028	3.276579261	0.002183481	0.283914285
131	GOSR1	golgi SNAP receptor complex	9527	NM_001007024.1	0.092600962	6.795254442	3.271571079	0.002214098	0.283914285
		member 1
132	GAGE6	G antigen 6	2578	NM_001476.1	0.084017945	6.682459172	3.264048516	0.002260854	0.283914285
133	APEX1	APEX nuclease (multifunctional	328	NM_080649.1	−0.205907613	10.29653222	−3.263741347	0.002262783	0.283914285
		DNA repair enzyme) 1
134	DEFA4	“defensin, alpha 4, corticostatin”	1669	NM_001925.1	1.278228028	8.166305327	3.261061773	0.002279678	0.283914285
135	NULL	NULL	654161	XM_944884.1	0.104968986	6.718195712	3.257061934	0.002305119	0.283914285
136	NUDT15	nudix (nucleoside diphosphate	55270	NM_018283.1	0.123752342	6.885930043	3.255768591	0.002313403	0.283914285
		linked moiety X)-type motif 15
137	NULL	NULL	NULL	BF434110	0.123387473	6.780690807	3.249401682	0.002354598	0.283914285
138	UFM1	ubiquitin-fold modifier 1	51569	NM_016617.1	−0.290998607	7.377470679	−3.247199714	0.002369006	0.283914285
139	PPCS	phosphopantothenoylcysteine	79717	NM_001077447.1	−0.310167811	8.568975401	−3.246841442	0.002371358	0.283914285
		synthetase
140	NOL8	nucleolar protein 8	55035	NM_017948.4	−0.189491166	7.101045922	−3.245977565	0.002377039	0.283914285
141	ARHGAP26	Rho GTPase activating protein 26	23092	NM_015071.3	0.134940814	6.848659921	3.24444167	0.002387172	0.283914285
142	LOC284757	—	284757	NM_001004305.1	0.123817908	6.718141693	3.240499839	0.002413364	0.283914285
143	OSTCL	oligosaccharyltransferase complex	202459	NM_145303.2	0.060154691	6.581023808	3.238217924	0.00242865	0.283914285
		subunit-like
144	MGC2752	—	65996	NM_023939.3	0.119350056	6.792942939	3.237415006	0.002434051	0.283914285
145	NULL	NULL	648399	XM_937448.1	−0.092941768	6.644024172	−3.234527246	0.00245357	0.283914285
146	ZNF700	zinc finger protein 700	90592	NM_144566.1	−0.134476397	7.002962787	−3.234466743	0.00245398	0.283914285
147	C6orf222	chromosome 6 open reading frame	389384	NM_001010903.3	0.050501562	6.569327079	3.231679197	0.002472965	0.283914285
		222
148	CCDC135	coiled-coil domain containing 135	84229	NM_032269.4	0.099558313	6.682670608	3.231179152	0.002476386	0.283914285
149	PCDH17	protocadherin 17	27253	NM_014459.2	−0.527638621	7.136230311	−3.222695445	0.002535104	0.284452992
150	ZDHHC9	“zinc finger, DHHC-type containing	51114	NM_016032.2	0.119706025	6.997375053	3.217216624	0.002573725	0.284452992
		9”
151	LRRN3	leucine rich repeat neuronal 3	54674	NM_001099660.1	−0.625504431	7.682637114	−3.214775054	0.002591115	0.284452992
152	BPTF	bromodomain PHD finger	2186	NM_004459.6	0.091882838	6.908904599	3.213818559	0.002597958	0.284452992
		transcription factor
153	ABLIM1	actin binding LIM protein 1	3983	NM_006720.3	−0.4799407	9.683313038	−3.211379067	0.002615488	0.284452992
154	DNAJA2	“DnaJ (Hsp40) homolog, subfamily	10294	NM_005880.2	−0.266568167	10.14561262	−3.210741465	0.002620088	0.284452992
		A, member 2”
155	ESRRA	estrogen-related receptor alpha	2101	NM_004451.3	0.246532485	7.560235207	3.209923275	0.002626002	0.284452992
156	C10orf58	chromosome 10 open reading frame	84293	NM_032333.2	−0.327354271	12.01556757	−3.208768803	0.002634369	0.284452992
		58
157	Sept7	septin 7	989	NM_001788.4	−0.31815245	7.233902696	−3.207967599	0.002640191	0.284452992
158	NULL	NULL	NULL	CA847896	−0.142130207	6.698943452	−3.206384308	0.002651731	0.284452992
159	YY1	YY1 transcription factor	7528	NM_003403.3	−0.328869705	8.107148479	−3.204275996	0.002667172	0.284452992
160	DSC1	desmocollin 1	1823	NM_004948.2	−0.207019876	6.793195915	−3.200364719	0.002696043	0.284452992
161	CLEC2D	“C-type lectin domain family 2,	29121	NM_001004419.2	−0.163087579	6.794369704	−3.198257031	0.002711724	0.284452992
		member D”
162	PRPF18	PRP18 pre-mRNA processing	8559	NM_003675.3	−0.26670234	7.878626332	−3.197713488	0.002715782	0.284452992
		factor 18 homolog (S. cerevisiae)
163	G3BP1	GTPase activating protein (SH3	10146	NM_005754.2	−0.241645343	7.052446591	−3.185861616	0.002805707	0.292068911
		domain) binding protein 1
164	MST150	—	85027	NM_032947.3	0.146021285	6.865433004	3.176860762	0.002875877	0.296708297
165	TBC1D4	“TBC1 domain family, member 4”	9882	NM_014832.2	−0.247692111	7.386975828	−3.174355605	0.002895701	0.296708297
166	NULL	NULL	641848	XM_935588.1	−0.645965338	9.336735576	−3.173470885	0.002902733	0.296708297
167	LOC646197	—	646197	XM_929153.1	−0.239784184	7.328222264	−3.166981614	0.002954807	0.300222595
168	NULL	NULL	NULL	BX111675	0.054993081	6.598572236	3.162436409	0.002991807	0.302172471
169	STX2	syntaxin 2	2054	NM_001980.2	−0.258793675	8.129855454	−3.160200443	0.003010169	0.302228045
170	MTRR	5-methyltetrahydrofolate-	4552	NM_024010.1	−0.355492388	8.577705624	−3.152664579	0.003072842	0.306705797
		homocysteine methyltransferase
		reductase
171	RPS3A	ribosomal protein S3A	6189	NM_001006.3	−0.224696704	13.45225898	−3.146532931	0.003124746	0.308412922
172	IDH3A	isocitrate dehydrogenase 3 (NAD+)	3419	NM_005530.2	−0.146008756	7.834975506	−3.146351122	0.003126298	0.308412922
		alpha
173	ABCC13	“ATP-binding cassette, sub-family	150000	NR_003087.1	0.143863548	6.975180019	3.143481172	0.003150887	0.309041948
		C (CFTR/MRP), member 13”
174	PFN2	profilin 2	5217	NM_053024.2	−0.101946483	6.657579392	−3.139339792	0.003186693	0.310064384
175	UBE2Q1	ubiquitin-conjugating enzyme E2Q	55585	NM_017582.5	0.154304568	7.337098311	3.138057327	0.003197859	0.310064384
		family member 1
176	AMMECR1	“Alport syndrome, mental	9949	NM_015365.2	−0.137410703	7.232010532	−3.13384834	0.003234765	0.310661839
		retardation, midface hypoplasia and
		elliptocytosis chromosomal region
177	C1orf116	chromosome 1 open reading frame	79098	NM_023938.5	0.160946362	7.087582262	3.131317441	0.00325715	0.310661839
		116
178	NULL	NULL	NULL	AI807878	−0.087151047	6.620513943	−3.13111503	0.003258947	0.310661839
179	SACS	spastic ataxia of Charlevoix-	26278	NM_014363.3	−0.121241812	6.762655646	−3.11937001	0.003364815	0.313968641
		Saguenay (sacsin)
180	LSM14B	“LSM14B, SCD6 homolog B (S. cerevisiae)”	149986	NM_144703.2	0.096185097	6.699394363	3.118872143	0.003369373	0.313968641
181	XAF1	XIAP associated factor 1	54739	NM_199139.1	0.524120564	8.118813402	3.118616591	0.003371715	0.313968641
182	C19orf10	chromosome 19 open reading frame	56005	NM_019107.3	0.409044609	8.364952884	3.11477554	0.003407106	0.313968641
		10
183	LY6H	“lymphocyte antigen 6 complex,	4062	NM_002347.2	0.197994096	7.625459259	3.11379814	0.003416167	0.313968641
		locus H”
184	PTPLB	“protein tyrosine phosphatase-like	201562	NM_198402.2	−0.266540406	8.55593686	−3.113403603	0.003419831	0.313968641
		(proline instead of catalytic
		arginine), member b”
185	GPBP1	GC-rich promoter binding protein 1	65056	NM_022913.1	−0.264875927	7.600558229	−3.111547981	0.003437115	0.313968641
186	RPLP2	“ribosomal protein, large, P2”	6181	NM_001004.2	−0.118887297	15.00311102	−3.11020746	0.003449652	0.313968641
187	RNF11	ring finger protein 11	26994	NM_014372.3	0.225580915	7.461433616	3.109081409	0.003460217	0.313968641
188	INPP4B	“inositol polyphosphate-4-	8821	NM_003866.1	−0.281061337	7.795763622	−3.104207785	0.003506294	0.313968641
		phosphatase, type II, 105 kDa”
189	FAM162A	“family with sequence similarity	26355	NM_014367.3	−0.324511803	7.752271827	−3.10396735	0.003508582	0.313968641
		162, member A”
190	MORF4L1	mortality factor 4 like 1	10933	NM_206839.1	−0.24904666	10.34569001	−3.102150665	0.003525916	0.313968641
191	SCAMP5	secretory carrier membrane protein 5	192683	NM_138967.2	0.0612925	6.631370252	3.098618399	0.003559852	0.313968641
192	CCDC89	coiled-coil domain containing 89	220388	NM_152723.1	0.204429972	7.482187696	3.09753939	0.003570279	0.313968641
193	MEGF10	multiple EGF-like-domains 10	84466	NM_032446.1	0.047723662	6.628265945	3.096096662	0.003584267	0.313968641
194	SATB1	SATB homeobox 1	6304	NM_002971.2	−0.216171431	7.186778766	−3.09531339	0.003591883	0.313968641
195	ABCA10	“ATP-binding cassette, sub-family	10349	NM_080282.3	−0.111376806	6.625364772	−3.093640769	0.003608197	0.313968641
		A (ABC1), member 10”
196	MRPL9	mitochondrial ribosomal protein L9	65005	NM_031420.2	−0.156554264	8.221670276	−3.087455651	0.003669133	0.31454873
197	TAPBPL	TAP binding protein-like	55080	NM_018009.3	0.214867322	8.1474735	3.086165839	0.003681962	0.31454873
198	COL6A2	“collagen, type VI, alpha 2”	1292	NM_058175.2	0.063152686	6.561772793	3.085397873	0.003689621	0.31454873
199	LOC439949	—	439949	XM_001129241.1	−0.469330965	9.557830109	−3.085250381	0.003691093	0.31454873
200	KIAA0947	—	23379	NM_015325.1	−0.180354486	7.294868393	−3.078574853	0.003758327	0.31454873
201	ZBP1	Z-DNA binding protein 1	81030	NM_030776.1	0.273696455	8.206083343	3.075164636	0.003793118	0.31454873
202	ZFAND1	“zinc finger, AN1-type domain 1”	79752	NM_024699.1	−0.254784176	7.600944243	−3.071364143	0.003832248	0.31454873
203	CTSG	cathepsin G	1511	NM_001911.2	1.254662256	8.153662815	3.066769075	0.003880067	0.31454873
204	WIPI1	“WD repeat domain,	55062	NM_017983.4	0.224176607	7.728118352	3.066646213	0.003881354	0.31454873
		phosphoinositide interacting 1”
205	NULL	NULL	NULL	AA532505	−0.182665342	6.801109687	−3.064162052	0.003907447	0.31454873
206	CETP	“cholesteryl ester transfer protein,	1071	NM_000078.1	0.23667459	7.0432678	3.063834245	0.003910903	0.31454873
		plasma”
207	PNN	“pinin, desmosome associated	5411	NM_002687.3	−0.314789132	8.884666033	−3.062982207	0.003919898	0.31454873
		protein”
208	HMGB2	high-mobility group box 2	3148	NM_002129.2	−0.440289057	9.197446056	−3.062831664	0.00392149	0.31454873
209	KIAA0495	—	57212	NM_207306.1	0.103342047	6.804792712	3.054813009	0.004007139	0.31454873
210	INADL	InaD-like (Drosophila)	10207	NM_176878.1	−0.241811563	7.411681346	−3.052446632	0.00403275	0.31454873
211	NULL	NULL	402251	XM_377933.3	−0.279019599	13.20844854	−3.05231587	0.004034169	0.31454873
212	PMAIP1	phorbol-12-myristate-13-acetate-	5366	NM_021127.1	−0.206408928	6.932806262	−3.051907227	0.004038609	0.31454873
		induced protein 1
213	ERVWE1	“endogenous retroviral family W,	30816	NM_014590.3	−0.11912978	6.669466439	−3.051740881	0.004040418	0.31454873
		env(C7), member 1”
214	DEFB125	“defensin, beta 125”	245938	NM_153325.2	0.07618092	6.649380002	3.050659019	0.004052199	0.31454873
215	GALNT6	UDP-N-acetyl-alpha-D-	11226	NM_007210.3	0.080267134	6.753373034	3.050508823	0.004053837	0.31454873
		galactosamine:polypeptide N-
		acetylgalactosaminyltransferase 6
216	PABPC1	“poly(A) binding protein,	26986	NM_002568.3	−0.393451244	8.998065664	−3.049628157	0.004063455	0.31454873
		cytoplasmic 1”
217	TFIP11	tuftelin interacting protein 11	24144	NM_001008697.1	−0.334180963	7.760123364	−3.049354132	0.004066452	0.31454873
218	NAE1	NEDD8 activating enzyme E1	8883	NM_001018160.1	−0.29276015	7.771592744	−3.044929903	0.004115128	0.31454873
		subunit 1
219	ANKRD10	ankyrin repeat domain 10	55608	NM_017664.2	−0.170575575	7.64901735	−3.039743162	0.004172892	0.31454873
220	GM2A	GM2 ganglioside activator	2760	NM_000405.3	0.266114128	7.061105638	3.038262899	0.004189517	0.31454873
221	NULL	NULL	NULL	AW510851	0.206747428	7.083271693	3.038237159	0.004189807	0.31454873
222	NULL	NULL	NULL	BC032017	0.065153173	6.608790075	3.036217154	0.004212596	0.31454873
223	MERTK	c-mer proto-oncogene tyrosine	10461	NM_006343.2	0.178168499	6.954953554	3.0358305	0.004216971	0.31454873
		kinase
224	AP3M2	“adaptor-related protein complex 3,	10947	NM_006803.2	−0.269660186	7.913987405	−3.035147683	0.004224709	0.31454873
		mu 2 subunit”
225	DKFZp761E198	—	91056	NM_138368.3	0.361999782	7.249752149	3.033989667	0.004237861	0.31454873
226	ADD3	adducin 3 (gamma)	120	NM_001121.2	−0.331309202	10.1268842	−3.032530689	0.004254487	0.31454873
227	CDC16	cell division cycle 16 homolog (S. cerevisiae)	8881	NM_001078645.1	−0.262987116	9.820606346	−3.030775491	0.004274569	0.31454873
228	KIAA1147	KIAA1147	57189	XM_001130020.1	−0.162506963	7.004494336	−3.030736896	0.004275012	0.31454873
229	UQCRC2	ubiquinol-cytochrome c reductase	7385	NM_003366.2	−0.306901413	9.073083441	−3.029625432	0.004287776	0.31454873
		core protein II
230	UBA6	ubiquitin-like modifier activating	55236	NM_018227.5	−0.194843638	7.532537393	−3.028380957	0.00430211	0.31454873
		enzyme 6
231	ROM1	retinal outer segment membrane	6094	NM_000327.2	0.090241562	6.729914462	3.028098053	0.004305375	0.31454873
		protein 1
232	NR2C1	“nuclear receptor subfamily 2,	7181	NM_003297.1	−0.155303368	6.991172468	−3.0280023	0.004306481	0.31454873
		group C, member 1”
233	F12	coagulation factor XII (Hagema	2161	NM_000505.3	0.095388359	6.762822694	3.026085058	0.004328674	0.31454873
		factor)
234	ARMC8	armadillo repeat containing 8	25852	NM_014154.2	−0.087200394	6.632486359	−3.025296236	0.004337836	0.31454873
235	ATP11B	“ATPase, class VI, type 11B”	23200	NM_014616.1	−0.252853775	7.626141524	−3.008423755	0.004538234	0.32615798
236	NGLY1	N-glycanase 1	55768	NM_018297.2	−0.197659111	8.023132987	−3.007062614	0.004554774	0.32615798
237	SFRS12	“splicing factor, arginine/serine-rich	140890	NM_001077199.1	−0.290167988	7.753512191	−3.003361465	0.004600037	0.32615798
		12”
238	NULL	NULL	643272	XM_926633.1	−0.171519101	6.729150181	−3.002858425	0.004606221	0.32615798
239	SNN	stannin	8303	NM_003498.4	0.236846461	7.364580648	3.002384307	0.004612057	0.32615798
240	NULL	NULL	NULL	BU753725	0.072652165	6.618401869	3.001859946	0.00461852	0.32615798
241	HIGD1A	“HIG1 domain family, member 1A”	25994	NM_014056.1	−0.279289648	8.999208769	−2.995323082	0.004699801	0.32615798
242	KCTD5	potassium channel tetramerisation	54442	NM_018992.2	0.23125854	8.529271571	2.995052196	0.004703198	0.32615798
		domain containing 5
243	KIAA1370	KIAA1370	56204	NM_019600.1	−0.224539294	7.456650271	−2.994813967	0.004706187	0.32615798
244	APEX1	APEX nuclease (multifunctional	328	NM_001641.2	−0.196094396	9.738672442	−2.992976895	0.0047293	0.32615798
		DNA repair enzyme) 1
245	RABGGTA	“Rab geranylgeranyltransferase,	5875	NM_182836.1	0.121605116	6.86888209	2.992774267	0.004731856	0.32615798
		alpha subunit”
246	C2orf18	chromosome 2 open reading frame	54978	NM_017877.3	0.137500886	6.87955857	2.992710778	0.004732657	0.32615798
		18
247	AK5	adenylate kinase 5	26289	NM_012093.2	−0.119581494	6.636155047	−2.988854547	0.004781554	0.32615798
248	HERC2P3	hect domain and RLD 2 pseudogene 3	283755	XM_001128358.1	−0.175308013	6.682973877	−2.988111751	0.004791027	0.32615798
249	ATP5C1	“ATP synthase, H+ transporting,	509	NM_005174.2	−0.369186445	10.44337548	−2.98421357	0.00484103	0.32615798
		mitochondrial F1 complex, gamma
		polypeptide 1”
250	IMMT	“inner membrane protein,	10989	NM_001100169.1	−0.221779779	8.555082028	−2.983540607	0.004849711	0.32615798
		mitochondrial (mitofilin)”
251	XIAP	X-linked inhibitor of apoptosis	331	NM_001167.2	0.07202812	6.621201373	2.981911934	0.004870783	0.32615798
252	C14orf4	chromosome 14 open reading frame 4	64207	NM_024496.2	0.29452834	7.653210546	2.979013545	0.004908495	0.32615798
253	NULL	NULL	645550	XM_928570.1	−0.065705517	6.590349507	−2.978667878	0.00491301	0.32615798
254	RPL9	ribosomal protein L9	6133	NM_001024921.2	−0.56653985	11.40544642	−2.975268779	0.004957625	0.32615798
255	NULL	NULL	NULL	BM717102	0.080470357	6.717739236	2.975115397	0.004959647	0.32615798
256	ZBBX	“zinc finger, B-box domain	79740	NM_024687.2	0.067673114	6.679035963	2.97421524	0.00497153	0.32615798
		containing”
257	UPK3A	uroplakin 3A	7380	NM_006953.2	0.082445237	6.698973174	2.971686744	0.005005051	0.32615798
258	NULL	NULL	NULL	AI479380	0.091888829	6.633620699	2.968887484	0.00504241	0.32615798
259	CAPZA1	“capping protein (actin filament)	829	NM_006135.1	−0.36644329	7.449870807	−2.968385028	0.005049143	0.32615798
		muscle Z-line, alpha 1”
260	FBXO38	F-box protein 38	81545	NM_030793.3	−0.149047116	6.882751518	−2.96757563	0.005060008	0.32615798
261	NBPF14	“neuroblastoma breakpoint family,	25832	NM_015383.1	−0.189228519	7.28417605	−2.967517575	0.005060788	0.32615798
		member 14”
262	MYC	v-myc myelocytomatosis viral	4609	NM_002467.3	−0.38321124	8.439937979	−2.965923374	0.005082253	0.32615798
		oncogene homolog (avian)
263	UBA3	ubiquitin-like modifier activating	9039	NM_198197.1	−0.187898967	7.02054307	−2.964535444	0.005101011	0.32615798
		enzyme 3
264	TRIOBP	TRIO and F-actin binding protein	11078	NM_138632.2	0.133302598	7.129841312	2.963553212	0.005114326	0.32615798
265	RPL7	ribosomal protein L7	6129	NM_000971.3	−0.354882331	10.11769817	−2.962843057	0.005123972	0.32615798
266	CNOT7	“CCR4-NOT transcription complex,	29883	NM_013354.5	−0.212744803	8.998078077	−2.962376643	0.005130317	0.32615798
		subunit 7”
267	ALDH7A1	“aldehyde dehydrogenase 7 family,	501	NM_001182.2	−0.068559518	6.611321514	−2.960459925	0.005156468	0.32615798
		member A1”
268	OR11L1	“olfactory receptor, family 11,	391189	NM_001001959.1	0.101699642	6.879400128	2.960040266	0.005162211	0.32615798
		subfamily L, member 1”
269	GUSBL2	“glucuronidase, beta-like 2”	375513	NM_206910.1	0.128073825	6.907202924	2.958648625	0.005181296	0.32615798
270	AZU1	azurocidin 1	566	NM_001700.3	0.606626505	7.0491903	2.957871261	0.005191986	0.32615798
271	DUSP26	dual specificity phosphatase 26	78986	NM_024025.1	0.086230095	6.832117186	2.956626422	0.005209147	0.32615798
		(putative)
272	TIA1	TIA1 cytotoxic granule-associated	7072	NM_022173.1	−0.154497679	7.045284603	−2.951573346	0.005279357	0.328639571
		RNA binding protein
273	RPL23	ribosomal protein L23	9349	NM_000978.3	−0.338815803	11.96776242	−2.949718357	0.005305352	0.328639571
274	FKRP	fukutin related protein	79147	NM_024301.3	0.120111732	6.815052027	2.944636349	0.005377187	0.328639571
275	GNL3L	guanine nucleotide binding protein-	54552	NM_019067.4	0.338634328	7.473595121	2.94338078	0.005395075	0.328639571
		like 3 (nucleolar)-like
276	NULL	NULL	NULL	CF552427	0.054930882	6.640898885	2.941052051	0.005428399	0.328639571
277	LOC642934	—	642934	XM_942991.2	−0.452151346	9.850733599	−2.938312313	0.005467851	0.328639571
278	RPL5	ribosomal protein L5	6125	NM_000969.3	−0.250479654	13.11440201	−2.936873997	0.005488671	0.328639571
279	TMEM189	transmembrane protein 189	387521	NM_199129.1	0.148299783	7.711569894	2.936068915	0.005500356	0.328639571
280	EIF1AX	“eukaryotic translation initiation	1964	NM_001412.3	−0.259913717	7.91454554	−2.935272494	0.005511939	0.328639571
		factor 1A, X-linked”
281	TCERG1	transcription elongation regulator 1	10915	NM_006706.3	−0.153163323	7.597318359	−2.934764583	0.005519338	0.328639571
282	TNIP2	TNFAIP3 interacting protein 2	79155	NM_024309.2	0.160957185	7.341463538	2.934623572	0.005521394	0.328639571
283	FLVCRt	feline leukemia virus subgroup C	28982	NM_014053.1	0.133852915	6.983247308	2.934521625	0.005522881	0.328639571
		cellular receptor 1
284	OSBPL1A	oxysterol binding protein-like 1A	114876	NM_080597.2	0.088316231	6.818536942	2.932343132	0.00555474	0.328639571
285	DHX15	DEAH (Asp-Glu-Ala-His) box	1665	NM_001358.2	−0.188453408	9.249900465	−2.931629933	0.005565207	0.328639571
		polypeptide 15
286	PLEKHN1	“pleckstrin homology domain	84069	NM_032129.1	0.124659553	6.987594206	2.929799098	0.005592163	0.328639571
		containing, family N member 1”
287	ATM	ataxia telangiectasia mutated	472	NM_000051.3	−0.361381652	8.817161402	−2.926480737	0.005641331	0.328639571
288	AKTIP	AKT interacting protein	64400	NM_022476.2	−0.132110131	7.173375215	−2.926408412	0.005642407	0.328639571
289	MGC10997	—	84741	NR_001565.1	−0.229371406	10.57230382	−2.926241638	0.005644889	0.328639571
290	NULL	NULL	648210	XR_018923.1	−0.404442095	10.47351845	−2.925088264	0.005662083	0.328639571
291	GRB14	growth factor receptor-bound	2888	NM_004490.2	0.107052844	6.780507016	2.924443935	0.00567171	0.328639571
		protein 14
292	UGCG	UDP-glucose ceramide	7357	NM_003358.1	0.348634208	7.672012128	2.923971985	0.005678771	0.328639571
		glucosyltransferase
293	BCR	breakpoint cluster region	613	NM_021574.2	0.074331836	6.624980953	2.923844748	0.005680676	0.328639571
294	KCNJ14	“potassium inwardly-rectifying	3770	NM_170720.1	0.076087153	6.618374084	2.922939338	0.00569425	0.328639571
		channel, subfamily J, member 14”
295	NDFIP1	Nedd4 family interacting protein 1	80762	NM_030571.2	−0.171766084	7.624592155	−2.921558194	0.005715014	0.328719859
296	LOC644131	—	644131	XR_018325.1	−0.244724622	7.573926707	−2.919946228	0.005739338	0.329003667
297	SPN	sialophorin	6693	NM_001030288.1	0.34574151	8.247211489	2.914907743	0.005815992	0.332014809
298	RBPJ	recombination signal binding protein	3516	NM_203284.1	0.254681218	8.653397128	2.913617187	0.00583578	0.332014809
		for immunoglobulin kappa J region
299	NULL	NULL	NULL	BM677010	−0.224636988	6.908713574	−2.911624953	0.00586645	0.332014809
300	SEH1L	SEH1-like (S. cerevisiae)	81929	NM_031216.3	−0.083010039	6.697203672	−2.911306261	0.005871371	0.332014809

TABLE 3
List of top 300 genes selected by SAM.
SAM
No.	Probe ID	Name of gene	Description of gene	EntrezID	Acc
1	1400240	LDHB	lactate dehydrogenase B	3945	NM_002300.4
2	4830255	DPP4	dipeptidyl-peptidase 4	1803	NM_001935.3
3	3990608	MAN2A1	“mannosidase, alpha, class 2A,	4124	NM_002372.2
			member 1”
4	1780719	PTGES3	prostaglandin E synthase 3	10728	NM_006601.4
			(cytosolic)
5	3130370	ZNF83	zinc finger protein 83	55769	NM_018300.2
8	3130477	C7orf28A	chromosome 7 open reading frame	51622	XM_001133729.1
			28A
7	4220731	P4HA1	“prolyl 4-hydroxylase, alpha	5033	NM_000917.2
			polypeptide 1”
8	3440189	ZBTB20	zinc finger and BTB domain	26137	NM_015642.3
			containing 20
9	1780709	DDX17	DEAD (Asp-Glu-Ala-Asp) box	10521	NM_030881.2
			polypeptide 17
10	160253	MBNL1	muscleblind-like (Drosophila)	4154	NM_207295.1
11	510209	LOC643310	—	643310	XM_926656.1
12	5900129	CROP	—	51747	NM_006107.2
13	7320424	HNRPA1L-2	—	664709	NR_002944.2
14	6110630	HIST1H2BK	“histone cluster 1, H2bk”	85236	NM_080593.1
15	6420446	CMPK1	“cytidine monophosphate (UMP-	51727	NM_016308.1
			CMP) kinase 1, cytosolic”
16	6590484	NAP1L1	nucleosome assembly protein 1-like	4673	NM_139207.1
17	1110091	TIAL1	TIA1 cytotoxic granule-associated	7073	NM_001033925.1
			RNA binding protein-like 1
18	150706	UGP2	UDP-glucose pyrophosphorylase 2	7360	NM_006759.3
19	6940176	ACTR3	ARP3 actin-related protein 3	10096	NM_005721.3
			homolog (yeast)
20	2100594	BUB3	budding uninhibited by	9184	NM_004725.2
			benzimidazoles 3 homolog (yeast)
21	3130296	AMY2A	“amylase, alpha 2A (pancreatic)”	279	NM_000699.2
22	840064	LOC645489	—	645489	XM_928514.1
23	1570491	hCG_2015956	—	648000	XM_371757.5
24	520706	UBE4A	“ubiquitination factor E4A (UFD2	9354	NM_004788.2
			homolog, yeast)”
25	990315	TCP1	t-complex 1	6950	NM_030752.2
26	4880521	CDC16	cell division cycle 16 homolog (S. cerevisiae)	8881	NM_003903.3
27	3290689	C14orf166	chromosome 14 open reading frame	51637	NM_016039.1
			166
28	6940433	STAT5B	signal transducer and activator of	6777	NM_012448.3
			transcription 5B
29	4050195	FAM10A4	“family with sequence similarity 10,	145165	NR_002183.1
			member A4 pseudogene”
30	6110091	WSB1	WD repeat and SODS box-	26118	NM_134265.2
			containing 1
31	840358	EXOSC10	exosome component 10	5394	NM_002685.2
32	4570255	LEF1	lymphoid enhancer-binding factor 1	51176	NM_016269.2
33	7550358	NELL2	NEL-like 2 (chicken)	4753	NM_006159.1
34	1010315	L1NS1	lines homolog 1 (Drosophila)	55180	NM_001040614.1
35	4210129	ELOVL5	“ELOVL family member 5,	60481	NM_021814.3
			elongation of long chain fatty acids
			(FEN1/Elo2, SUR4/Elo3-like,
36	5420053	CCT6P1	“chaperonin containing TCP1,	643253	NR_003110.2
			subunit 6 (zeta) pseudogene 1”
37	730379	LOC388621	—	388621	XM_941195.2
38	6550600	MYC	v-myc myelocytomatosis viral	4609	NM_002467.3
			oncogene homolog (avian)
39	5860465	USP9Y	“ubiquitin specific peptidase 9, Y-	8287	NM_004654.3
			linked (fat facets-like, Drosophila)”
40	1500201	HNRNPC	heterogeneous nuclear	3183	NM_031314.1
			ribonucleoprotein C (C1/C2)
41	6180497	GOLGA8C	“golgi autoantigen, golgin subfamily	400304	XM_375152.3
			a, 8C”
42	3360228	RPS20	ribosomal protein S20	6224	NM_001023.2
43	6110747	GIMAP2	“GTPase, IMAP family member 2”	26157	NM_015660.2
44	6980253	PTPLB	“protein tyrosine phosphatase-like	201562	NM_198402.2
			(proline instead of catalytic
			arginine), member b”
45	2570358	HNRPDL	heterogeneous nuclear	9987	NM_031372.1
			ribonucleoprotein D-like
46	2360630	FDFT1	farnesyl-diphosphate	2222	NM_004462.3
			farnesyltransferase 1
47	6420309	FAM134B	“family with sequence similarity	54463	NM_001034850.1
			134, member B”
48	2370041	LRRN3	leucine rich repeat neuronal 3	54674	NM_018334.3
49	3180438	RPS3A	ribosomal protein S3A	6189	NM_001006.3
50	1990487	XRN1	5′-3′ exoribonuclease 1	54464	NM_019001.2
51	2230538	LRRN3	leucine rich repeat neuronal 3	54674	NM_001099660.1
52	6900750	HDAC2	histone deacetylase 2	3066	NM_001527.2
53	150672	KLHL7	kelch-like 7 (Drosophila)	55975	NM_001031710.1
54	2970370	PCDH17	protocadherin 17	27253	NM_014459.2
55	2640255	NULL	NULL	641848	XM_935588.1
56	2570112	ABLIM1	actin binding LIM protein 1	3983	NM_006720.3
57	5910463	PKIA	“protein kinase (cAMP-dependent,	5569	NM_006823.2
			catalytic) inhibitor alpha”
58	5560465	NOP56	NOP56 ribonucleoprotein homolog	10528	NM_006392.2
			(yeast)
59	2600204	SACM1L	SAC1 suppressor of actin	22908	NM_014016.2
			mutations 1-like (yeast)
60	4050328	DSC1	desmocollin 1	1823	NM_004948.2
61	6860148	SLC9A6	“solute carrier family 9	10479	NM_001042537.1
			(sodium/hydrogen exchanger),
			member 6”
62	5960072	NULL	NULL	NULL	BY797688
63	3420068	HAT1	histone acetyltransferase 1	8520	NM_003642.2
64	2570725	PPCS	phosphopantothenoylcysteine	79717	NM_001077447.1
			synthetase
65	2680102	NULL	NULL	649555	XM_945579.1
66	1690605	NULL	NULL	649088	XM_938168.1
67	2650601	GPBP1L1	GC-rich promoter binding protein	60313	NM_021639.3
			1-like 1
68	4540356	UFM1	ubiquitin-fold modifier 1	51569	NM_016617.1
69	2120468	C10orf58	chromosome 10 open reading frame	84293	NM_032333.2
			58
70	6760017	YY1	YY1 transcription factor	7528	Table
					NM_0 3
71	450195	Sept7	septin 7	989	NM_001788.4
72	6510433	SNORA33	“small nucleolar RNA, H/ACA box	594839	NR_002436.1
			33”
73	580014	C12orf43	chromosome 12 open reading frame	64897	NM_022895.1
			43
74	5340487	MTRR	5-methyltetrahydrofolate-	4552	NM_024010.1
			homocysteine methyltransferase
			reductase
75	2370372	NULL	NULL	NULL	CX782759
76	60053	RPL11	ribosomal protein L11	6135	NM_000975.2
77	4050609	DNAJA2	“DnaJ (Hsp40) homolog, subfamily	10294	NM_005880.2
			A, member 2”
78	4560088	LOC439949	—	439949	XM_001129241.1
79	5860327	PRPF18	PRP18 pre-mRNA processing	8559	NM_003675.3
			factor 18 homolog (S. cerevisiae)
80	5810619	TADA1L	“transcriptional adaptor 1 (HFI1	117143	NM_053053.2
			homolog, yeast)-like”
81	6510053	APEX1	APEX nuclease (multifunctional	328	NM_080649.1
			DNA repair enzyme) 1
82	5900482	HMGB2	high-mobility group box 2	3148	NM_002129.2
83	5720300	G3BP1	GTPase activating protein (SH3	10146	NM_005754.2
			domain) binding protein 1
84	7650669	TBC1D4	“TBC1 domain family, member 4”	9882	NM_014832.2
85	6380673	TUBE1	“tubulin, epsilon 1”	51175	NM_016262.3
86	5310736	FAM162A	“family with sequence similarity	26355	NM_014367.3
			162, member A”
87	7400343	STX2	syntaxin 2	2054	NM_001980.2
88	3060040	PABPC1	“poly(A) binding protein,	26986	NM_002568.3
			cytoplasmic 1”
89	110195	LOC646197	—	646197	XM_929153.1
90	2120017	NOL8	nucleolar protein 8	55035	NM_017948.4
91	6860259	DSC1	desmocollin 1	1823	NM_004948.2
92	4860762	INPP4B	“inositol polyphosphate-4-	8821	NM_003866.1
			phosphatase, type II, 105 KDa”
93	6420730	RPL9	ribosomal protein L9	6133	NM_001024921.2
94	4560270	PTPLB	“protein tyrosine phosphatase-like	201562	NM_198402.2
			(proline instead of catalytic
			arginine), member b”
95	1090692	GPBP1	GC-rich promoter binding protein 1	65056	NM_022913.1
96	7150132	PNN	“pinin, desmosome associated	5411	NM_002687.3
			protein”
97	2600600	TFIP11	tuftelin interacting protein 11	24144	NM_001008697.1
98	6560164	RPS3A	ribosomal protein S3A	6189	NM_001006.3
99	1070475	RPL11	ribosomal protein L11	6135	NM_000975.2
100	1990468	ADD3	adducin 3 (gamma)	120	NM_001121.2
101	4900343	MORF4L1	mortality factor 4 like 1	10933	NM_206839.1
102	6510619	NAE1	NEDD8 activating enzyme E1	8883	NM_001018160.1
			subunit 1
103	3440670	NULL	NULL	402251	XM_377933.3
104	5220195	UQCRC2	ubiquinol-cytochrome c reductase	7385	NM_003366.2
			core protein II
105	7380707	ZFAND1	“zinc finger, AN1-type domain 1”	79752	NM_024699.1
106	4780450	ATP5C1	“ATP synthase, H+ transporting,	509	NM_005174.2
			mitochondrial F1 complex, gamma
			polypeptide 1”
107	5420095	MYC	v-myc myelocytomatosis viral	4609	NM_002467.3
			oncogene homolog (avian)
108	7040482	LOC642934	—	642934	XM_942991.2
109	4610138	CAPZA1	“capping protein (actin filament)	829	NM_006135.1
			muscle Z-line, alpha 1”
110	3420128	AP3M2	“adaptor-related protein complex 3,	10947	NM_006803.2
			mu 2 subunit”
111	3130669	SATB1	SATB homeobox 1	6304	NM_002971.2
112	2570132	CLEC2D	“C-type lectin domain family 2,	29121	NM_001004419.2
			member D”
113	5360619	CDC16	cell division cycle 16 homolog (S. cerevisiae)	8881	NM_001078645.1
114	2680082	RPL7	ribosomal protein L7	6129	NM_000971.3
115	2340632	INADL	InaD-like (Drosophila)	10207	NM_176878.1
116	2060050	NULL	NULL	NULL	BM932227
117	6900044	AMN1	antagonist of mitotic exit network 1	196394	NM_207337.1
			homolog (S. cerevisiae)
118	5900731	SFRS12	“splicing factor, arginine/serine-rich	140890	NM_001077199.1
			12”
119	4760243	NULL	NULL	648210	XR_018923.1
120	7550341	HIGD1A	“HIG1 domain family, member 1A”	25994	NM_014056.1
121	380575	RPL23	ribosomal protein L23	9349	NM_000978.3
122	6650594	ATP11B	“ATPase, class VI, type 11B”	23200	NM_014616.1
123	3780465	SMARCA5	“SWI/SNF related, matrix	8467	NM_003601.2
			associated, actin dependent
			regulator of chromatin, subfamily a,
124	6840605	ATM	ataxia telangiectasia mutated	472	NM_000051.3
125	670209	ZNF700	zinc finger protein 700	90592	NM_144566.1
126	2120307	NULL	NULL	NULL	CA847896
127	110332	NULL	NULL	NULL	XM_378421
128	6020598	PMAIP1	phorbol-12-myristate-13-acetate-	5366	NM_021127.1
			induced protein 1
129	4220307	NULL	NULL	647673	XM_936731.1
130	3180131	hCG_1984468	—	389672	XM_933893.1
131	4570170	KIAA0947	—	23379	NM_015325.1
132	5260161	NULL	NULL	NULL	AA532505
133	4180142	KIAA1370	KIAA1370	56204	NM_019600.1
134	3930561	PRKCI	“protein kinase C, iota”	5584	NM_002740.5
135	3360100	IDH3A	isocitrate dehydrogenase 3 (NAD+)	3419	NM_005530.2
			alpha
136	6200747	LOC220433	—	220433	XM_941684.2
137	2070019	UBA6	ubiquitin-like modifier activating	55236	NM_018227.5
			enzyme 6
138	2810601	LEF1	lymphoid enhancer-binding factor 1	51176	NM_016269.2
139	1010477	ADD3	adducin 3 (gamma)	120	NM_016824.3
140	3190059	IMMT	“inner membrane protein,	10989	NM_001100169.1
			mitochondrial (mitofilin)”
141	3930296	EIF1AX	“eukaryotic translation initiation	1964	NM_001412.3
			factor 1A, X-linked”
142	3780670	NGLY1	N-glycanase 1	55768	NM_018297.2
143	3930382	NMT2	N-myristoyltransferase 2	9397	NM_004808.1
144	830609	RPL5	ribosomal protein L5	6125	NM_000969.3
145	1410603	RAB3IP	RAB3A interacting protein (rabin3)	117177	NM_001024647.2
146	4010735	MRPL9	mitochondrial ribosomal protein L9	65005	NM_031420.2
147	2340601	AMMECR1	“Alport syndrome, mental	9949	NM_015365.2
			retardation, midface hypoplasia and
			elliptocytosis chromosomal region
148	7610608	RP11-122C9.1	—	653702	NM_001093763.1
149	3120309	APEX1	APEX nuclease (multifunctional	328	NM_001641.2
			DNA repair enzyme) 1
150	4540689	ANKRD10	ankyrin repeat domain 10	55608	NM_017664.2
151	4590241	CNOT7	“CCR4-NOT transcription complex,	29883	NM_013354.5
			subunit 7”
152	5820202	LOC644131	—	644131	XR_018325.1
153	1450471	FAM153B	“family with sequence similarity	202134	XM_371783.3
			153, member B”
154	6770673	SOCS2	suppressor of cytokine signaling 2	8835	NM_003877.3
155	160047	LOC389787	—	389787	XM_497072.2
156	160079	MGC10997	—	84741	NR_001565.1
157	460386	PTMA	“prothymosin, alpha”	5757	NM_001099285.1
158	990044	KIAA1147	KIAA1147	57189	XM_001130020.1
159	780402	RTN4	reticulon 4	57142	NM_020532.4
160	4040113	NULL	NULL	643272	XM_926633.1
161	4860431	NBPF14	“neuroblastoma breakpoint family,	25832	NM_015383.1
			member 14”
162	4830100	HSP90AB1	“heat shock protein 90 kDa alpha	3326	NM_007355.2
			(cytosolic), class B member 1”
163	3440709	NULL	NULL	NULL	BM677010
164	460196	HERC2P3	hect domain and RLD 2 pseudogene 3	283755	XM_001128358.1
165	2760553	UBA3	ubiquitin-like modifier activating	9039	NM_198197.1
			enzyme 3
166	5130674	CSE1L	CSE1 chromosome segregation 1-	1434	NM_001316.2
			like (yeast)
167	5310747	PSIP1	PC4 and SFRS1 interacting protein 1	11168	NM_033222.2
168	270544	NR2C1	“nuclear receptor subfamily 2,	7181	NM_003297.1
			group C, member 1”
169	430577	DDX50	DEAD (Asp-Glu-Ala-Asp) box	79009	NM_024045.1
			polypeptide 50
170	5890661	GIMAP2	“GTPase, IMAP family member 2”	26157	NM_015660.2
171	5360692	LY9	lymphocyte antigen 9	4063	NM_002348.2
172	6510246	NULL	NULL	648210	XR_018923.1
173	7510379	SACS	spastic ataxia of Charlevoix-	26278	NM_014363.3
			Saguenay (sacsin)
174	1980201	WWP1	WW domain containing E3 ubiquitin	11059	NM_007013.3
			protein ligase 1
175	4590333	DHX15	DEAH (Asp-Glu-Ala-His) box	1665	NM_001358.2
			polypeptide 15
176	770021	PRKRA	“protein kinase, interferon-inducible	8575	NM_003690.3
			double stranded RNA dependent
			activator”
177	4850097	RPLP2	“ribosomal protein, large, P2”	6181	NM_001004.2
178	4250154	NULL	NULL	648749	XM_937834.2
179	1440121	tcag7.1261	—	645968	XM_928934.1
180	4860066	NULL	NULL	647346	XM_936495.2
181	6280521	NULL	NULL	648399	XM_937448.1
182	7000377	PHIP	pleckstrin homology domain	55023	NM_017934.4
			interacting protein
183	6100288	Sept15	—	9403	NM_004261.3
184	2600035	NCL	nucleolin	4691	NM_005381.2
185	2260168	NULL	NULL	731640	XM_001133089.1
186	6900634	CD69	CD69 molecule	969	NM_001781.1
187	1780348	FH	fumarate hydratase	2271	NM_000143.2
188	6280408	TTN	titin	7273	NM_003319.3
189	60553	NDFIP1	Nedd4 family interacting protein 1	80762	NM_030571.2
190	4880204	SPRYD5	SPRY domain containing 5	84767	NM_032681.1
191	620450	RNASEH2B	“ribonuclease H2, subunit B”	79621	NM_024570.1
192	2710653	FBXO38	F-box protein 38	81545	NM_030793.3
193	4610681	LOC653658	—	653658	XM_939687.2
194	4850133	SNRPN	small nuclear ribonucleoprotein	6638	NM_022806.2
			polypeptide N
195	1850300	TC2N	“tandem C2 domains, nuclear”	123036	NM_152332.3
196	3120075	TIA1	TIA1 cytotoxic granule-associated	7072	NM_022173.1
			RNA binding protein
197	6130538	PFN2	profilin 2	5217	NM_053024.2
198	3190541	ABCA10	“ATP-binding cassette, sub-family	10349	NM_080282.3
			A (ABC1), member 10”
199	6590441	TRIP12	thyroid hormone receptor interactor	9320	NM_004238.1
			12
200	2190390	NCOA1	nuclear receptor coactivator 1	8648	NM_147223.2
201	3610521	PCDHGB6	“protocadherin gamma subfamily B,	56100	NM_018926.2
			6”
202	4150408	P2RY2	“purinergic receptor P2Y, G-protein	5029	NM_002564.2
			coupled, 2”
203	4810072	TUSC2	tumor suppressor candidate 2	11334	NM_007275.1
204	2640025	HP	haptoglobin	3240	NM_005143.2
205	3890315	ERVWE1	“endogenous retroviral family W,	30816	NM_014590.3
			env(C7), member 1”
206	6860615	LOC147804	—	147804	NR_003148.2
207	7380068	CNBP	“CCHC-type zinc finger, nucleic	7555	NM_003418.1
			acid binding protein”
208	6660286	INTS8	integrator complex subunit 8	55656	NM_017864.2
209	6450538	TCERG1	transcription elongation regulator 1	10915	NM_006706.3
210	3140047	CROP	—	51747	NM_016424.3
211	3830136	NACAP1	nascent-polypeptide-associated	83955	NR_002182.1
			complex alpha polypeptide
			pseudogene 1
212	3800707	XPO4	exportin 4	64328	NM_022459.3
213	5700670	WIPF1	“WAS/WASL interacting protein	7456	NM_003387.3
			family, member 1”
214	2230167	LOC653773	—	653773	XM_938755.2
215	4640739	NULL	NULL	NULL	AL120241
216	6650672	ZNF439	zinc finger protein 439	90594	NM_152262.2
217	7400376	RABL2A	“RAB, member of RAS oncogene	11159	NM_013412.1
			family-like 2A”
218	6020273	RPS4Y2	“ribosomal protein S4, Y-linked 2”	140032	NM_001039567.2
219	6560564	PRKCA	“protein kinase C, alpha”	5578	NM_002737.2
220	1300687	NULL	NULL	731950	XR_016039.1
221	1980626	SMARCA5	“SWI/SNF related, matrix	8467	NM_003601.2
			associated, actin dependent
			regulator of chromatin, subfamily a,
222	3370112	RPN2	ribophorin II	6185	NM_002951.2
223	6270148	AK5	adenylate kinase 5	26289	NM_012093.2
224	6620356	ARPP-19	—	10776	NM_006628.4
225	6370435	ETS1	v-ets erythroblastosis virus E26	2113	NM_005238.2
			oncogene homolog 1 (avian)
226	1190064	UGT2B7	“UDP glucuronosyltransferase 2	7364	XM_001128725.1
			family, polypeptide B7”
227	1570292	NULL	NULL	NULL	AI807878
228	2640551	CMPK1	“cytidine monophosphate (UMP-	51727	NM_016308.1
			CMP) kinase 1, cytosolic”
229	2570328	TRIB2	tribbles homolog 2 (Drosophila)	28951	NM_021643.1
230	5720703	AKTIP	AKT interacting protein	64400	NM_022476.2
231	7000474	GARNL1	GTPase activating Rap/RanGAP	253959	NM_194301.2
			domain-like 1
232	1990390	RAB3IP	RAB3A interacting protein (rabin3)	117177	NM_175624.2
233	1410246	BBS2	Bardet-Biedl syndrome 2	583	NM_031885.2
234	5910543	GLOD4	glyoxalase domain containing 4	51031	NM_016080.2
235	5360204	NMD3	NMD3 homolog (S. cerevisiae)	51068	NM_015938.3
236	3710048	NULL	NULL	731895	XM_001133620.1
237	2900039	XRCC5	X-ray repair complementing	7520	NM_021141.2
			defective repair in Chinese hamster
			cells 5 (double-strand-break
238	6770563	NULL	NULL	650215	XR_018889.1
239	1820300	CTSO	cathepsin O	1519	NM_001334.2
240	940398	EIF3M	“eukaryotio translation initiation	10480	NM_006360.3
			factor 3, subunit M”
241	3940358	OSBPL8	oxysterol binding protein-like 8	114882	NM_001003712.1
242	6650161	GNA13	“guanine nucleotide binding protein	10672	NM_006572.3
			(G protein), alpha 13”
243	2100292	RBBP7	retinoblastoma binding protein 7	5931	NM_002893.2
244	6020066	NULL	NULL	651202	XM_940333.2
245	6770315	LOC391656	—	391656	XM_373027.4
246	70753	C9orf123	chromosome 9 open reading frame	90871	NM_033428.1
			123
247	7330014	SNX4	sorting nexin 4	8723	NM_003794.2
248	6020575	NNT	nicotinamide nucleotide	23530	NM_012343.3
			transhydrogenase
249	7200021	CUL4A	cullin 4A	8451	NM_003589.2
250	7150554	LCOR	ligand dependent nuclear receptor	84458	NM_032440.1
			corepressor
251	3850278	NULL	NULL	641849	XM_935589.1
252	2190379	NULL	NULL	390856	XM_938867.1
253	3990112	CAST	calpastatin	831	NM_001042445.1
254	7000521	PRPS2	phosphoribosyl pyrophosphate	5634	NM_001039091.1
			synthetase 2
255	620546	RRAS2	related RAS viral (r-ras) oncogene	22800	NM_012250.3
			homolog 2
256	6760670	C7orf28B	chromosome 7 open reading frame	221960	XM_001126212.1
			28B
257	770128	L3MBTL3	l(3)mbt-like 3 (Drosophila)	84456	NM_032438.1
258	6590646	FAM26F	“family with sequence similarity 26,	441168	NM_001010919.1
			member F”
259	2030767	CD48	CD48 molecule	962	NM_001778.2
260	3170020	DGKA	“diacylglycerol kinase, alpha 80 kDa”	1606	NM_201554.1
261	5820392	CCT6A	“chaperonin containing TCP1,	908	NM_001009186.1
			subunit 6A (zeta 1)”
262	2760068	NULL	NULL	NULL	AK023178
263	2750367	PMAIP1	phorbol-12-myristate-13-acetate-	5366	NM_021127.1
			induced protein 1
264	6580270	KRT18P31	keratin 18 pseudogene 31	646723	XR_017241.1
265	4890292	TSHZ2	teashirt zinc finger homeobox 2	128553	NM_173485.4
266	6400243	ABLIM1	actin binding LIM protein 1	3983	NM_001003407.1
267	6550750	ARMC8	armadillo repeat containing 8	25852	NM_014154.2
268	5290056	TRIM48	tripartite motif-containing 48	79097	NM_024114.2
269	7000037	ZFAND1	“zinc finger, AN1-type domain 1”	79752	NM_024699.1
270	1770546	ATIC	5-aminoimidazole-4-carboxamide	471	NM_004044.4
			ribonucleotide
			formyltransferase/IMP
271	870181	LOC653314	—	653314	NM_001080544.1
272	5550463	FARSB	“phenylalanyl-tRNA synthetase,	10056	NM_005687.2
			beta subunit”
273	2690561	RPLP1	“ribosomal protein, large, P1”	6176	NM_001003.2
274	6860681	IER3IP1	immediate early response 3	51124	NM_016097.3
			interacting protein 1
275	5810435	SNAP23	“synaptosomal-associated protein,	8773	NM_003825.2
			23 kDa”
276	5490403	CD1E	CD1e molecule	913	NM_001042586.1
277	670195	NUDCD2	NudC domain containing 2	134492	NM_145266.4
278	3460162	NULL	NULL	646900	XM_929862.1
279	160537	KDSR	3-ketodihydrosphingosine	2531	NM_002035.1
			reductase
280	1240450	CD27	CD27 molecule	939	NM_001242.4
281	430100	XRCC6	X-ray repair complementing	2547	NM_001469.3
			defective repair in Chinese hamster
			cells 6
282	360719	CD44	CD44 molecule (Indian blood group)	960	NM_000610.3
283	520673	LRFN5	leuoine rich repeat and fibronectin	145581	NM_152447.2
			type III domain containing 5
284	3800678	NUP88	nucleoporin 88 kDa	4927	NM_002532.3
285	6370717	GNG10	“guanine nucleotide binding protein	2790	NM_001017998.2
			(G protein), gamma 10”
286	2650653	ZNF75D	zinc finger protein 75D	7626	NM_007131.2
287	6020093	SARS	seryl-tRNA synthetase	6301	NM_006513.2
288	5360592	NULL	NULL	729985	XM_001131964.1
289	5960332	SLC39A10	“solute carrier family 39 (zinc	57181	NM_020342.1
			transporter), member 10”
290	940500	CLDN14	claudin 14	23562	NM_012130.2
291	7400047	LOC388344	—	388344	XM_371023.4
292	3930689	DHX9	DEAH (Asp-Glu-Ala-His) box	1660	NM_001357.2
			polypeptide 9
293	6280524	CCNL1	cyclin L1	57018	NM_020307.2
294	1820528	PAPSS1	3′-phosphoadenosine 5′-	9061	NM_005443.4
			phosphosulfate synthase 1
295	1050148	LOC653264	—	653264	XM_932721.2
296	3830156	GTF3C3	“general transcription factor IIIC,	9330	NM_012086.2
			polypeptide 3; 102 kDa”
297	4590349	ACVR2A	“activin A receptor, type IIA”	92	NM_001616.3
298	2260551	RAD21	RAD21 homolog (S. pombe)	5885	NM_006265.1
299	6510600	MLLT10	“myeloid/lymphoid or mixed-lineage	8028	NM_004641.2
			leukemia (trithorax homolog,
			Drosophila); translocated to, 10”
300	3610348	FAM10A4	“family with sequence similarity 10,	145165	NR_002183.1
			member A4 pseudogene”
	No.	limma_logFC	SAM_FoldChange	SAM_qvalue	SAM_pvalue
	1	−0.605485777	0.657250037	0	7.20E−05
	2	−0.307400655	0.808096419	0	9.00E−05
	3	−0.327379686	0.796982701	0	0.00010897
	4	−0.528677962	0.693189659	0	0.000118989
	5	−0.30567958	0.809061019	0	0.000143446
	8	−0.383441629	0.766606625	0	0.000185113
	7	−0.307837835	0.807851578	0	0.00019578
	8	−0.287117754	0.819537713	0	0.000201968
	9	−0.443292451	0.735454273	0	0.000244932
	10	−0.320695796	0.800683623	0	0.000260019
	11	−0.395581648	0.760182834	0	0.000271806
	12	−0.443849065	0.735170578	0	0.000277699
	13	−0.432630765	0.740909499	0	0.000287011
	14	0.379122401	1.300550483	2.69772513	7.89E−05
	15	−0.398631213	0.758577658	4.54353706	0.000348715
	16	−0.357418456	0.780560051	4.54353706	0.000349599
	17	−0.233908998	0.850327795	4.54353706	0.000350012
	18	−0.347146055	0.786137702	4.54353706	0.000409771
	19	−0.459963089	0.727004859	4.54353706	0.000412423
	20	−0.303162523	0.810473813	4.54353706	0.000416549
	21	−0.282794372	0.821997339	4.54353706	0.000476957
	22	−0.199041088	0.871129382	4.54353706	0.000500236
	23	−0.31840088	0.801958296	4.54353706	0.00054479
	24	−0.230502672	0.852337864	4.54353706	0.000554868
	25	−0.256767834	0.83696092	4.54353706	0.000575613
	26	−0.34380491	0.787960431	4.54353706	0.000582037
	27	−0.321385016	0.800301204	4.54353706	0.000582449
	28	−0.24015242	0.846655859	4.54353706	0.000583746
	29	−0.370567771	0.773478035	4.54353706	0.000601073
	30	−0.29256262	0.816450531	4.54353706	0.000625825
	31	−0.226165883	0.854903874	4.54353706	0.000671087
	32	−0.599827856	0.659832683	4.54353706	0.000692126
	33	−0.537157632	0.689127277	4.54353706	0.000734795
	34	−0.286168405	0.820077178	4.54353706	0.000818423
	35	−0.284710319	0.820906424	4.54353706	0.0008186
	36	−0.281922881	0.822494034	4.54353706	0.000831565
	37	−0.448108038	0.733003485	4.54353706	0.000873114
	38	−0.337363684	0.791486318	4.54353706	0.000906648
	39	−0.094524102	0.936581144	4.886445518	0.000963284
	40	−0.397999182	0.758910057	4.886445518	0.000981436
	41	−0.242008817	0.84556712	4.886445518	0.000987093
	42	−0.162977591	0.893179726	4.886445518	0.000998468
	43	−0.45531031	0.729353278	4.886445518	0.001029408
	44	−0.336175973	0.792138184	4.886445518	−0.001054809
	45	−0.382998221	0.766842276	4.886445518	0.001060879
	46	−0.242595956	0.845223066	4.886445518	0.001090582
	47	−0.358481173	0.779985293	4.886445518	0.001129538
	48	−0.383213794	0.7667277	4.886445518	0.001144625
	49	−0.215689394	0.861134567	4.886445518	0.001155882
	50	−0.23813416	0.847841118	4.886445518	0.001159241
	51	−0.625504431	0.6481931	4.886445518	0.001186233
	52	−0.308059644	0.807727384	4.886445518	0.001210868
	53	−0.155913324	0.897563974	4.886445518	0.001219177
	54	−0.527638621	0.693689224	4.886445518	0.001244342
	55	−0.645965338	0.639065035	4.886445518	0.001318364
	56	−0.4799407	0.717007095	4.886445518	0.0013407
	57	−0.254561014	0.838242158	4.886445518	0.001347006
	58	−0.266935568	0.831082978	4.886445518	0.001404762
	59	−0.262966982	0.83337228	4.886445518	0.00145079
	60	−0.247522067	0.842341957	4.886445518	0.001456801
	61	−0.17456976	0.886031712	5.912822202	0.001472713
	62	−0.097047292	0.934944549	5.912822202	0.0015
	63	−0.268653366	0.830094007	5.912822202	0.00151491
	64	−0.310167811	0.806547938	5.912822202	0.001552275
	65	−0.269621337	0.829537245	5.912822202	0.001556695
	66	−0.257637488	0.836456553	5.912822202	0.001568541
	67	−0.185092124	0.879592907	5.912822202	0.001609618
	68	−0.290998607	0.817336118	5.912822202	0.001621405
	69	−0.327354271	0.79699674	5.912822202	0.001658475
	70	−0.328869705	0.79616	5.912822202	0.001672796
	71	−0.31815245	0.802096404	5.912822202	0.001692185
	72	−0.186113851	0.878970194	5.912822202	0.001704385
	73	−0.20852646	0.865420704	5.912822202	0.001772749
	74	−0.355492388	0.781602839	5.912822202	0.001833805
	75	−0.206252167	0.866786046	5.912822202	0.001846299
	76	−0.156372832	0.897278139	5.912822202	0.00185231
	77	−0.266568167	0.831294651	5.912822202	0.001899988
	78	−0.469330965	0.722299479	5.912822202	0.001914722
	79	−0.26670234	0.831217343	5.912822202	0.001963873
	80	−0.16203449	0.893763795	5.912822202	0.001994991
	81	−0.205907613	0.866993082	5.912822202	0.002050743
	82	−0.440289057	0.736986932	5.912822202	0.002095945
	83	−0.241645343	0.84578018	7.047118706	0.002177393
	84	−0.247692111	0.84224268	7.047118706	0.002197843
	85	−0.138726153	0.908320815	7.047118706	0.00219802
	86	−0.324511803	0.79856857	7.047118706	0.002198491
	87	−0.258793675	0.835786479	7.047118706	0.00220633
	88	−0.393451244	0.761306212	7.047118706	0.002289604
	89	−0.239784184	0.846871989	7.047118706	0.002296146
	90	−0.189491166	0.876914952	7.047118706	0.002304809
	91	−0.207019876	0.866324921	7.047118706	0.002379125
	92	−0.281061337	0.822985355	7.047118706	0.002406412
	93	−0.56653985	0.675234325	7.047118706	0.002410655
	94	−0.266540406	0.831310647	7.047118706	0.002436292
	95	−0.264875927	0.832270308	7.047118706	0.002457744
	96	−0.314789132	0.803968492	7.047118706	0.002498645
	97	−0.334180963	0.793234338	7.047118706	0.002502416
	98	−0.224696704	0.855774915	7.047118706	0.002545674
	99	−0.145832491	0.903857666	7.047118706	0.002576674
	100	−0.331309202	0.794814886	7.047118706	0.002626355
	101	−0.24904666	0.841452268	7.047118706	0.002631424
	102	−0.29276015	0.816338752	7.047118706	0.002737683
	103	−0.279019599	0.824150889	7.047118706	0.002770038
	104	−0.306901413	0.808376108	7.047118706	0.002770156
	105	−0.254784176	0.838112505	7.047118706	0.002804514
	106	−0.369186445	0.774218966	7.047118706	0.002824257
	107	−0.38321124	0.766729057	7.047118706	0.002915665
	108	−0.452151346	0.73095204	7.047118706	0.002919319
	109	−0.36644329	0.775692474	7.047118706	0.002961398
	110	−0.269660186	0.829514908	7.047118706	0.002963637
	111	−0.216171431	0.860846891	7.047118706	0.002982438
	112	−0.163087579	0.893111634	7.047118706	0.002982614
	113	−0.262987116	0.833360649	7.047118706	0.003044024
	114	−0.354882331	0.781933417	7.047118706	0.003051686
	115	−0.241811563	0.845682739	7.047118706	0.003052275
	116	−0.116682268	0.92230622	7.047118706	0.003063178
	117	−0.126543905	0.916023233	7.047118706	0.003064298
	118	−0.290167988	0.817806827	7.047118706	0.003068423
	119	−0.404442095	0.755528407	7.047118706	0.00317421
	120	−0.279289648	0.823996635	7.047118706	0.003208746
	121	−0.338815803	0.790690062	7.047118706	0.003237093
	122	−0.252853775	0.839234694	7.047118706	0.00330976
	123	−0.115124978	0.923302323	7.047118706	0.003318835
	124	−0.361381652	0.77841874	7.047118706	0.003336162
	125	−0.134476397	0.911000407	7.047118706	0.003349717
	126	−0.142130207	0.90618015	7.047118706	0.003364274
	127	−0.394864244	0.760560941	7.047118706	0.003414781
	128	−0.206408928	0.866691867	9.763195707	0.003445073
	129	−0.504764306	0.704775508	9.763195707	0.003546617
	130	−0.387113765	0.764657839	9.763195707	0.003585337
	131	−0.180354486	0.882486133	9.763195707	0.003614274
	132	−0.182665342	0.881073731	9.763195707	0.003699434
	133	−0.224539294	0.855868293	9.763195707	0.003726839
	134	−0.105841727	0.929262615	9.763195707	0.003727074
	135	−0.146008756	0.903747242	9.763195707	0.003758487
	136	−0.448374765	0.732867979	9.763195707	0.003766914
	137	−0.194843638	0.873667581	9.763195707	0.003822136
	138	−0.524099452	0.695393047	9.763195707	0.00384512
	139	−0.307853518	0.807842797	9.763195707	0.003857496
	140	−0.221779779	0.857506921	9.763195707	0.003863449
	141	−0.259913717	0.835137865	9.763195707	0.00391702
	142	−0.197659111	0.871964248	9.763195707	0.00397731
	143	−0.314300806	0.804240667	9.763195707	0.003985738
	144	−0.250479654	0.840616888	9.763195707	0.003996346
	145	−0.350434199	0.784348002	9.763195707	0.004009135
	146	−0.156554264	0.897165305	9.763195707	0.004017975
	147	−0.137410703	0.9091494	9.763195707	0.004106848
	148	−0.316189323	0.803188588	9.763195707	0.004139616
	149	−0.196094396	0.872910474	9.763195707	0.004145863
	150	−0.170575575	0.888488141	9.763195707	0.004158887
	151	−0.212744803	0.862893968	9.763195707	0.004202793
	152	−0.244724622	0.843976877	9.763195707	0.004242928
	153	−0.346939529	0.786250247	9.763195707	0.00428542
	154	−0.524515864	0.695192362	9.763195707	0.004300625
	155	−0.49206406	0.711007134	9.763195707	0.00434571
	156	−0.229371406	0.853006473	9.763195707	0.004359913
	157	−0.590989351	0.66388748	9.763195707	0.004434111
	158	−0.162506963	0.893471142	9.763195707	0.004435761
	159	−0.274156562	0.826933624	9.763195707	0.00448562
	160	−0.171519101	0.887907258	9.763195707	0.004516914
	161	−0.189228519	0.877074612	9.763195707	0.004533652
	162	−0.346277597	0.786611074	9.763195707	0.004560644
	163	−0.224636988	0.855810338	9.763195707	0.004581447
	164	−0.175308013	0.88557843	9.763195707	0.004591702
	165	−0.187898967	0.877883274	9.763195707	0.004591761
	166	−0.226954625	0.854436614	9.763195707	0.004607379
	167	−0.298779917	0.812939606	9.763195707	0.004616219
	168	−0.155303368	0.897943535	9.763195707	0.004649104
	169	−0.230181634	0.852527552	9.763195707	0.004696605
	170	−0.289089079	0.818418647	9.763195707	0.004754008
	171	−0.25013536	0.840817522	9.763195707	0.004774694
	172	−0.402275661	0.756663804	9.763195707	0.004787482
	173	−0.121241812	0.919395932	9.763195707	0.004823904
	174	−0.293252037	0.816060469	9.763195707	0.004916018
	175	−0.188453408	0.87754596	9.763195707	0.004949375
	176	−0.229357783	0.853014528	9.763195707	0.005003418
	177	−0.118887297	0.920897635	9.763195707	0.005017739
	178	−0.061658345	0.958162101	9.763195707	0.005056518
	179	−0.360761142	0.778753613	9.763195707	0.005057756
	180	−0.209955699	0.864563779	9.763195707	0.005069543
	181	−0.092941768	0.937608941	9.763195707	0.005080504
	182	−0.262231952	0.833796978	9.763195707	0.005190653
	183	−0.282927999	0.821921206	9.763195707	0.005198963
	184	−0.219773695	0.858700124	9.763195707	0.00521847
	185	−0.328163712	0.796549701	9.763195707	0.005355375
	186	−0.483558921	0.715211123	9.763195707	0.005374882
	187	−0.232880465	0.850934231	9.763195707	0.005384371
	188	−0.519301868	0.697709379	9.763195707	0.005433758
	189	−0.171766084	0.887755265	9.763195707	0.005457685
	190	−0.301606617	0.811348358	9.763195707	0.005479196
	191	−0.267258493	0.830896974	9.763195707	0.005515794
	192	−0.149047116	0.901845925	9.763195707	0.005532001
	193	−0.384309209	0.766145757	9.763195707	0.005535596
	194	−0.341806565	0.789052629	9.763195707	0.005543612
	195	−0.236871126	0.848583701	9.763195707	0.005559111
	196	−0.154497679	0.898445141	9.763195707	0.005559288
	197	−0.101946483	0.931774993	9.763195707	0.005570898
	198	−0.111376806	0.925704214	9.763195707	0.00557302
	199	−0.196624966	0.872589509	9.763195707	0.005598244
	200	−0.208822548	0.865243109	9.763195707	0.005617751
	201	0.176789549	1.130365665	11.63540578	0.00016649
	202	0.182075591	1.134514927	11.63540578	0.000175978
	203	0.162628207	1.119324394	11.63540578	0.000383074
	204	0.40681683	1.325757427	11.63540578	0.000429338
	205	−0.11912978	0.920742867	11.63540578	0.005684052
	206	−0.199498342	0.870853326	11.63540578	0.005685349
	207	−0.327720874	0.796794242	11.63540578	0.005735207
	208	−0.26616918	0.831524583	11.63540578	0.005746818
	209	−0.153163323	0.899276502	11.63540578	0.00581695
	210	−0.279822544	0.823806524	11.63540578	0.005835278
	211	−0.386755375	0.764847816	11.63540578	0.005916077
	212	−0.217365077	0.860134944	11.63540578	0.005991513
	213	−0.282049908	0.822421618	11.63540578	0.006078678
	214	−0.368995191	0.774321609	11.63540578	0.006078736
	215	−0.069719279	0.952823381	11.63540578	0.006097065
	216	−0.168089512	0.89002051	11.63540578	0.006187294
	217	−0.178370764	0.883700396	11.63540578	0.006256129
	218	−0.29587893	0.814575919	11.63540578	0.006258428
	219	−0.258004675	0.83624369	11.63540578	0.006276462
	220	−0.061135983	0.958509089	11.63540578	0.006280823
	221	−0.146115776	0.903680204	11.63540578	0.006412188
	222	−0.275150971	0.826363839	11.63540578	0.006430752
	223	−0.119581494	0.920454623	11.63540578	0.006481612
	224	−0.261668585	0.834122636	11.63540578	0.006618753
	225	−0.467750348	0.723091264	11.63540578	0.006673916
	226	−0.170236569	0.888696943	11.63540578	0.006715523
	227	−0.087151047	0.941379899	11.63540578	0.006735266
	228	−0.272595837	0.827828695	11.63540578	0.006738036
	229	−0.296783847	0.814065144	11.63540578	0.006749057
	230	−0.132110131	0.912495829	11.63540578	0.006757485
	231	−0.175348366	0.88555366	11.63540578	0.006769861
	232	−0.152503427	0.89968793	11.63540578	0.006809936
	233	−0.21311697	0.862671399	11.63540578	0.006841113
	234	−0.177207323	0.884413331	11.63540578	0.006900106
	235	−0.201253758	0.86979435	11.63540578	0.007013673
	236	−0.292574951	0.816443553	11.63540578	0.007052393
	237	−0.210035123	0.864516184	11.63540578	0.007062176
	238	−0.218802016	0.859278667	11.63540578	0.00715541
	239	−0.231977107	0.851467219	11.63540578	0.007180693
	240	−0.395462504	0.760245616	11.63540578	0.007189062
	241	−0.261246813	0.834366527	11.63540578	0.007193482
	242	−0.380533537	0.76815346	11.63540578	0.007222006
	243	−0.173081269	0.886946341	11.63540578	0.007230669
	244	−0.466560508	0.723687868	11.63540578	0.007345238
	245	−0.243291277	0.844815801	11.63540578	0.00737612
	246	−0.214876999	0.861619616	11.63540578	0.007418199
	247	−0.223828966	0.856289793	11.63540578	0.007451379
	248	−0.191702435	0.875571903	11.63540578	0.007520215
	249	−0.244754746	0.843959254	11.63540578	0.007524576
	250	−0.293176479	0.816103209	11.63540578	0.007535596
	251	−0.303375497	0.810354178	11.63540578	0.007557638
	252	−0.244649266	0.844020961	11.63540578	0.00755976
	253	−0.280052769	0.823560894	11.63540578	0.007623645
	254	−0.203904286	0.868197825	11.63540578	0.007658416
	255	−0.155953995	0.897538671	11.63540578	0.007705976
	256	−0.202393059	0.869107741	11.63540578	0.007751061
	257	−0.161561418	0.894056916	11.63540578	0.007767798
	258	−0.364528742	0.776722551	11.63540578	0.007768152
	259	−0.244627443	0.844033729	11.63540578	0.007834807
	260	−0.286024075	0.820159224	11.63540578	0.007836752
	261	−0.24460782	0.844045209	13.42189746	0.007899045
	262	−0.17554108	0.885435376	13.42189746	0.008058286
	263	−0.426578629	0.744024158	13.42189746	0.008127829
	264	−0.149129275	0.901794568	13.42189746	0.008223008
	265	−0.248756168	0.841621714	13.42189746	0.008259842
	266	−0.349061324	0.785094747	13.42189746	0.008281707
	267	−0.087200394	0.9413477	13.42189746	0.008333392
	268	−0.116938426	0.922142474	13.42189746	0.008404173
	269	−0.243533327	0.844674072	13.42189746	0.008427098
	270	−0.256334047	0.837212614	13.42189746	0.008437824
	271	−0.223215014	0.856654272	13.42189746	0.008476073
	272	−0.160949186	0.894436404	13.42189746	0.008580446
	273	−0.685558024	0.621765286	13.42189746	0.008607143
	274	−0.206953948	0.866364511	13.42189746	0.008620934
	275	−0.266241158	0.831483098	13.42189746	0.008623291
	276	−0.151209281	0.900495342	13.42189746	0.008811704
	277	−0.186890942	0.878496874	13.42189746	0.008826438
	278	−0.302886246	0.810629034	13.42189746	0.00883516
	279	−0.165230376	0.891786103	13.42189746	0.0088971
	280	−0.37061142	0.773454634	13.42189746	0.008948079
	281	−0.202101353	0.869283488	13.42189746	0.008965229
	282	−0.236278041	0.848932621	13.42189746	0.00903041
	283	−0.181463688	0.881807903	13.42189746	0.009041077
	284	−0.225702407	0.855178562	13.42189746	0.009061763
	285	−0.296985545	0.81395134	13.42189746	0.00909789
	286	−0.135221715	0.910529892	13.42189746	0.009155705
	287	−0.201811182	0.869458346	13.42189746	0.009201968
	288	−0.159755362	0.895176853	13.42189746	0.009231023
	289	−0.147299889	0.902938799	13.42189746	0.009245757
	290	−0.153491707	0.899071834	13.42189746	0.009368576
	291	−0.327727336	0.796790672	13.42189746	0.009393152
	292	−0.143840193	0.905106716	13.42189746	0.009401285
	293	−0.186663803	0.878635196	13.42189746	0.009567716
	294	−0.222706769	0.856956115	13.42189746	0.009667845
	295	−0.102751263	0.931255365	13.42189746	0.009778347
	296	−0.154434592	0.89848443	13.42189746	0.009781058
	297	−0.105208688	0.929670455	13.42189746	0.009897749
	298	−0.356240374	0.781197711	13.42189746	0.009913602
	299	−0.211258659	0.863783307	13.42189746	0.009947313
	300	−0.192448279	0.875119368	13.42189746	0.009955446
	indicates data missing or illegible when filed

TABLE 4
List of top 300 genes selected by Rank Prod.
RankProd
No.	Probe ID	Name of gene	Description of gene	EntrezID	Acc	RP_Rsum	RP_FC	RP_pfp	RP_pval
1	2480600	LOC728358	—	728358	NM_001042500.1	206.9319	0.3679	0	0
2	7150170	LOC728358	—	728358	NM_001042500.1	217.1554	0.3807	0	0
3	2970747	DEFA3	defensin, alpha 3, neutrophil-	1668	NM_005217.2	221.4639	0.3779	0	0
			specific
4	4540239	DEFA1	defensin, alpha 1	1667	NM_004084.2	226.007	0.387	0	0
5	5080692	HLA-A29.1	—	649853	NM_001080840.1	232.3536	0.3703	0	0
6	870477	LOC728358	—	728358	NM_001042500.1	249.17	0.3939	0	0
7	7650497	ELA2	elastase 2, neutrophil	1991	NM_001972.2	273.8273	0.4006	0	0
8	6550164	DEFA4	defensin, alpha 4, corticostatin	1669	NM_001925.1	309.0369	0.4123	0	0
9	770400	NULL	NULL	653600	XM_928349.1	324.4866	0.4475	0	0
10	1500735	CTSG	cathepsin G	1511	NM_001911.2	324.7636	0.4191	0	0
11	3890349	HIST1H4C	histone cluster 1, H4c	8364	NM_003542.3	342.3622	0.5327	0	0
12	7330398	HLA-DRB4	major histocompatibility	3126	NM_021983.4	395.251	1.5402	0	0
			complex,
			class II, DR beta 4
13	5860075	CAMP	cathelicidin antimicrobial	820	NM_004345.3	426.4961	0.4888	0	0
			peptide
14	7050021	PRKAR1A	protein kinase,	5573	NR_002734.3	440.111	1.6574	0	0
			cAMP-dependent,
			regulatory, type I,
			alpha (tissue
			specific extinguisher 1)
15	4390398	LCN2	lipocalin 2	3934	NM_005564.3	468.6986	0.5216	0	0
16	4180768	ALAS2	aminolevulinate, delta-,	212	NM_001037968.1	494.2717	0.6935	0	0
			synthase 2
17	2690561	RPLP1	ribosomal protein, large, P1	6176	NM_001003.2	510.521	1.6083	0	0
18	4050717	MYOM2	myomesin (M-protein) 2,	9172	NM_003970.1	521.0537	0.6829	0	0
			165 kDa
19	3520601	MPO	myeloperoxidase	4353	NM_000250.1	552.0527	0.5121	0	0
20	1450358	HBD	hemoglobin, delta	3045	NM_000519.3	555.1003	0.636	0	0
21	620544	HLA-DRB6	major histocompatibility	3128	NR_001298.1	599.5065	1.2864	0	0
			complex,
			class II, DR beta 6
			(pseudogene)
22	6660288	CCL3L1	chemokine (C-C motif)	6349	NM_021006.4	608.9901	1.3171	0	0
			ligand 3-like 1
23	2350274	ERAF	erythroid associated factor	51327	NM_016633.2	624.2449	0.6242	0	0
24	6560376	RPS26L1	ribosomal protein S26-like 1	441502	NR_002309.1	627.4099	0.6128	0	0
25	6960195	NULL	NULL	650646	XM_942527.2	659.4889	0.6133	0	0
26	2230538	LRRN3	leucine rich repeat neuronal 3	54674	NM_001099660.1	663.6339	1.5428	0	0
27	6180743	LAIR2	leukocyte-associated	3904	NM_021270.2	674.7421	0.6789	0	0
			immunoglobulin-like
			receptor 2
28	2230601	UTS2	urotensin 2	10911	NM_021995.1	682.1642	1.3557	0	0
29	6590377	RPS26	ribosomal protein S26	6231	NM_001029.3	684.9927	0.6457	0	0
30	2640255	NULL	NULL	641848	XM_935588.1	694.3737	1.5648	0	0
31	5890730	RPS26L	—	400156	XR_017804.1	698.1257	0.6497	0	0
32	3520102	CCL4L1	chemokine (C-C motif)	9560	NM_001001435.2	700.5086	1.4296	0	0
			ligand 4-like 1
33	6860048	UTS2	urotensin 2	10911	NM_021995.1	717.5432	1.4062	0	0
34	5260484	HLA-DRB1	major histocompatibility	3123	NM_002124.1	718.7641	0.7652	0	0
			complex,
			class II, DR beta 1
35	50278	LAIR2	leukocyte-associated	3904	NM_002288.3	739.419	0.6969	0	0
			immunoglobulin-like
			receptor 2
36	4570255	LEF1	lymphoid enhancer-binding	51176	NM_016269.2	762.7748	1.5155	0	0
			factor 1
37	460386	PTMA	prothymosin, alpha	5757	NM_001099285.1	764.6714	1.5063	0	0
38	4670048	RPS26L	—	400156	NR_002225.2	796.2257	0.6646	0	0
39	6420730	RPL9	ribosomal protein L9	6133	NM_001024921.2	797.4422	1.481	0	0
40	6960022	5-Sep	septin 5	5413	NM_002688.4	812.1586	0.6894	0	0
41	6180427	G0S2	G0/G1switch 2	50486	NM_015714.2	832.1428	1.1905	0	0
42	5290762	UTS2	urotensin 2	10911	NM_006786.2	832.6698	1.2965	0	0
43	780403	HLA-DQA1	major histocompatibility	3117	XM_936128.2	837.2042	1.3738	0	0
			complex,
			class II, DQ alpha 1
44	1010246	IFI6	interferon; alpha-inducible	2537	NM_022872.2	838.9897	0.6667	0	0
			protein 6
45	6270307	LOC644934	—	644934	XM_930344.2	846.7408	0.6838	0	0
46	4780075	CEACAM8	carcinoembryonic	1088	NM_001816.2	851.5188	0.6171	0	0
			antigen-related
			cell adhesion molecule 8
47	1450139	FCGR3B	Fc fragment of IgG,	2215	NM_000570.3	852.2208	0.7809	0	0
			low affinity IIIb,
			receptor (CD16b)
48	1400240	LDHB	lactate dehydrogenase B	3945	NM_002300.4	869.5601	1.5215	0	0
49	2810601	LEF1	lymphoid enhancer-binding	51176	NM_0162692	885.7056	1.438	0	0
			factor 1
50	4230121	RPS26L	—	400156	XR_017804.1	901.0353	0.6857	0	0
51	50689	C7orf28B	chromosome 7 open reading	221960	NM_198097.1	901.4464	1.283	0	0
			frame 28B
52	7160475	SNHG5	small nucleolar	387066	XM_943699.1	915.2623	1.3754	0	0
			RNA host gene 5
			(non-protein coding)
53	1010546	NULL	NULL	649143	XM_944822.1	940.4695	1.2482	0	0
54	4120053	PFKFB3	6-phosphofructo-2-	5209	NM_004566.2	949.932	0.7127	0	0
			kinase/fructose-2,6-
			biphosphatase 3
55	5870678	NULL	NULL	441763	XM_930284.1	959.3277	0.7098	0	0
56	6250615	PGLYRP1	peptidoglycan recognition	8993	NM_005091.1	978.6937	0.6314	0	0
			protein 1
57	5310044	NBPF20	neuroblastoma breakpoint	400818	NM_001037675.1	989.9365	0.6816	0	0
			family, member 20
58	7160474	HLA-DQB1	major histocompatibility	3119	NM_002123.2	993.2267	1.3788	0	0
			complex,
			class II, DQ beta 1
59	1510424	S100P	S100 calcium binding	6286	NM_005980.2	999.9308	0.776	0	0
			protein P
60	7550358	NELL2	NEL-like 2 (chicken)	4753	NM_006159.1	1000.2823	1.4511	0	0
61	6370435	ETS1	v-ets erythroblastosis	2113	NM_005238.2	1000.7099	1.383	0	0
			virus E26
			oncogene homolog 1 (avian)
62	4480730	HBM	hemoglobin, mu	3042	NM_001003938.3	1002.8748	0.7114	0	0
63	6770673	SOCS2	suppressor of cytokine	8835	NM_003877.3	1008.5738	1.4385	0	0
			signaling 2
64	3140242	KIR2DL3	killer cell immunoglobulin-	3804	NM_014511.3	1012.7829	0.7052	0	o
			like receptor,
			two domains, long
			cytoplasmic tail, 3
65	5390246	CCR7	chemokine (C-C motif)	1236	NM_001838.2	1024.3788	1.3396	0	0
			receptor 7
66	6280408	TTN	titin	7273	NM_003319.3	1040.0032	1.4333	0	0
67	840685	IL1B	interleukin 1, beta	3553	NM_000576.2	1043.9839	0.9118	0	0
68	1440564	RUNX3	runt-related transcription	864	NM_004350.2	1045.6015	0.7504	0	0
			factor 3
69	2640301	TNF	tumor necrosis factor (TNF	7124	NM_000594.2	1052.0345	0.9119	0	0
			superfamily, member 2)
70	160047	LOC389787	—	389787	XM_497072.2	1058.0289	1.4065	0	0
71	1500280	IFIT3	interferon-induced protein	3437	NM_001031683.1	1067.6439	0.7336	0	0
			with
			tetratricopeptide repeats 3
72	1780719	PTGES3	prostaglandin E synthase 3	10728	NM_006601.4	1094.4413	1.4426	0	0
			(cytosolic)
73	7610440	XAF1	XIAP associated factor 1	54739	NM_199139.1	1101.0267	0.6954	0	0
74	1260482	GZMK	granzyme K (granzyme 3;	3003	NM_002104.2	1101.0382	1.379	0	0
			tryptase II)
75	2570112	ABLIM1	actin binding LIM protein 1	3983	NM_006720.3	1109.2206	1.3947	0	0
76	5810685	THBS1	thrombospondin 1	7057	NM_003246.2	1112.0822	0.7981	0	0
77	1050292	GP9	glycoprotein IX (platelet)	2815	NM_000174.2	1121.2912	0.7089	0	0
78	4010181	FOLR3	folate receptor 3 (gamma)	2352	NM_000804.2	1121.4294	0.7343	0	0
79	1580025	GNG11	guanine nucleotide	2791	NM_004126.3	1123.8896	0.7606	0	0
			binding protein
			(G protein), gamma 11
80	4220307	NULL	NULL	647673	XM_936731.1	1127.0089	1.4189	0	0
81	4220246	CCL20	chemokine (C-C motif)	6364	NM_004591.1	1130.1869	0.8647	0	0
			ligand 20
82	6270605	LOC649946	—	649946	NR_003040.1	1141.8104	1.3897	0	0
83	3370202	ANXA2P1	annexin A2 pseudogene 1	303	NR_001562.1	1148.68	1.3614	0	0
84	6020066	NULL	NULL	651202	XM_940333.2	1156.9854	1.3818	0	0
85	2970370	PCDH17	protocadherin 17	27253	NM_014459.2	1159.006	1.4416	0	0
86	2970575	CCL4L2	chemokine (C-C motif)	388372	NM_207007.2	1160.5275	0.8619	0	0
			ligand 4-like 2
87	3360615	FCER1A	Fc fragment of IgE,	2205	NM_002001.2	1161.9701	1.3166	0	0
			high affinity I,
			receptor for;
			alpha polypeptide
88	6900634	CD69	CD69 molecule	969	NM_001781.1	1185.7514	1.3982	0	0
89	650349	RPS28	ribosomal protein S28	6234	NM_001031.4	1190.4157	1.3501	0	0
90	6650242	IFITM3	interferon induced	10410	NM_021034.2	1198.6619	0.7139	0	0
			transmembrane
			protein 3 (1-8U)
91	2000148	IFIT1	interferon-induced	3434	NM_001548.3	1201.038	0.728	0	0
			protein with
			tetratricopeptide repeats 1
92	2190139	CA1	carbonic anhydrase I	759	NM_001738.1	1216.0508	0.7338	0	0
93	2140753	RPL14	ribosomal protein L14	9045	NM_001034996.1	1216.4627	1.3673	0	0
94	5050162	CD83	CD83 molecule	9308	NM_001040280.1	1221.184	1.1247	0	0
95	4200746	BPI	bactericidal/permeability-	671	NM_001725.1	1222.3488	0.676	0	0
			increasing protein
96	2600747	IFIT2	interferon-induced	3433	NM_001547.4	1226.2189	0.7229	0	0
			protein with
			tetratricopeptide repeats 2
97	3130543	RNASE3	ribonuclease,	6037	NM_002935.2	1231.3433	0.6719	0	0
			RNase A family, 3
			(eosinophil cationic protein)
98	5670739	AZU1	azurocidin 1	566	NM_001700.3	1238.4609	0.6567	0	0
99	7400377	CEACAM6	carcinoembryonic	4680	NM_002483.3	1240.5422	0.6648	0	0
			antigen-related
			cell adhesion molecule 6
			(non-specific cross
			reacting antigen)
100	4670390	CXCL2	chemokine (C—X—C motif)	2920	NM_002089.3	1243.1968	1.0736	0	0
			ligand 2
101	670010	NULL	NULL	650298	XM_939387.1	1255.7097	0.7673	0	0
102	6590682	CCL3	chemokine (C-C motif)	6348	NM_002983.1	1258.8623	1.0301	0	0
			ligand 3
103	4560088	LOC439949	—	439949	XM_001129241.1	1259.3189	1.3845	0	0
104	6220671	PLAUR	plasminogen activator,	5329	NM_001005376.1	1269.8919	0.7674	0	0
			urokinase receptor
105	3170152	IL2RB	interleukin 2 receptor, beta	3560	NM_000878.2	1271.1735	0.8008	0	0
106	6620026	CD83	CD83 molecule	9308	NM_004233.3	1287.9941	1.0467	0	0
107	2360164	KLRC2	killer cell lectin-like receptor	3822	NM_002260.3	1288.636	0.8481	0	0
			subfamily C, member 2
108	2650192	C6orf105	chromosome 6 open reading	84830	NM_032744.1	1289.3942	1.3412	0	0
			frame 105
109	2810010	CCL3L3	chemokine (C-C motif)	414062	NM_001001437.3	1296.3404	1.2483	0	0
			ligand 3-like 3
110	3190148	DDIT4	DNA-damage-inducible	54541	NM_019058.2	1307.8573	0.7086	0	0
			transcript 4
111	1770504	HLA-DRB3	major histocompatibility	3125	NM_022555.3	1317.7473	1.2121	0	0
			complex,
			class II, DR beta 3
112	6590594	HIST1H2AC	histone cluster 1, H2ac	8334	NM_003512.3	1319.1937	0.7494	0	0
113	2260129	MS4A6A	membrane-spanning	64231	NM_022349.2	1320.1527	1.2241	0	0
			4-domains,
			subfamily A, member 6A
114	2750367	PMAIP1	phorbol-12-myristate-13-	5366	NM_021127.1	1322.9263	1.344	0	0
			acetate-induced protein 1
115	5890095	LILRA5	leukocyte immunoglobulin-	353514	NM_021250.2	1328.6256	0.7741	0	0
			like receptor, subfamily A
			(with TM domain),
			member 5
116	2900360	KIR2DL4	killer cell	3805	NM_002255.3	1329.4767	0.7459	0	0
			immunoglobulin-like
			receptor, two domains,
			long cytoplamic tail, 4
117	6940176	ACTR3	ARP3 actin-related protein 3	10096	NM_005721.3	1331.182	1.3755	0	0
			homolog (yeast)
118	4010040	HBG2	hemoglobin, gamma G	3048	NM_000184.2	1331.5404	1.1022	0	0
119	270338	TRAT1	T cell receptor associated	50852	NM_016388.2	1334.9472	1.2985	0	0
			transmembrane adaptor 1
120	1070487	KLRC3	killer cell lectin-like receptor	3823	NM_002261.2	1341.8253	0.8231	0	0
			subfamily C, member 3
121	6770326	NLRP8	NLR family, pyrin domain	126205	NM_176811.2	1341.9389	1.2932	0	0
			containing 8
122	7160692	NULL	NULL	644250	XM_929199.1	1343.5684	1.3113	0	0
123	5870136	CLIC3	chloride intracellular	9022	NM_004669.2	1346.5828	0.7759	0	0
			channel 3
124	6200747	LOC220433	—	220433	XM_941684.2	1348.1888	1.3645	0	0
125	5260070	HES4	hairy and enhancer of split 4	57801	NM_021170.2	1348.7064	0.7167	0	0
			(Drosophila)
126	4250053	CCL3L1	chemokine (C-C motif)	6349	NM_021006.4	1356.1796	1.1002	0	0
			ligand 3-like 1
127	6580041	GNLY	granulysin	10578	NM_006433.2	1356.7575	0.7782	0	0
128	7040482	LOC642934	—	642934	XM_942991.2	1359.7468	1.3681	0	0
129	3890523	IL7R	interleukin 7 receptor	3575	XM_937367.1	1362.7824	1.2775	0	0
130	1340600	PPP1R15A	protein phosphatase 1,	23645	NM_014330.2	1373.0141	0.7984	0	0
			regulatory
			(inhibitor) subunit 15A
131	5900129	CROP	—	51747	NM_006107.2	1375.3663	1.3602	0	0
132	1010592	CD36	CD36 molecule	948	NM_001001548.1	1383.7856	1.1993	0	0
			(thrombospondin receptor)
133	5720682	TMEM176A	transmembrane protein 176A	55365	NM_018487.2	1384.9828	0.7916	1.00E−04	0
134	610437	CD24	CD24 molecule	100133941	NM_013230.2	1388.7966	0.7457	1.00E−04	0
135	4180079	CRISPLD2	cysteine-rich secretory protein	83716	NM_031476.2	1388.8351	0.72	1.00E−04	0
			LCCL domain containing 2
136	650112	LST1	leukocyte specific transcript 1	7940	NM_007161.2	1388.9553	0.7844	1.00E−04	0
137	520382	CLK1	CDC-like kinase 1	1195	NM_001024646.1	1395.6456	1.323	0	0
138	450537	HBG1	hemoglobin, gamma A	3047	NM_000559.2	1395.7174	1.0847	0	0
139	4490520	GPR183	G protein-coupled	1880	NM_004951.3	1395.8256	1.273	0	0
			receptor 183
140	4040398	MAL	mal, T-cell differentiation	4118	NM_022440.1	1396.4257	1.2775	0	0
			protein
141	5900482	HMGB2	high-mobility group box 2	3148	NM_002129.2	1396.9268	1.3569	0	0
142	510468	NFE2	nuclear factor	4778	NM_006163.1	1400.397	0.783	0	0
			(erythroid-derived 2),
			45 kDa
143	6330196	MAL	mal, T-cell differentiation	4118	NM_002371.2	1403.2124	1.2786	0	0
			protein
144	2100196	ISG15	ISG15 ubiquitin-like modifier	9636	NM_005101.1	1404.6098	0.7538	0	0
145	2260477	PTGS2	prostaglandin-endoperoxide	5743	NM_000963.1	1417.9779	1.1062	0	0
			synthase 2 (prostaglandin G/H
			synthase and cyclooxygenase)
146	1780709	DDX17	DEAD (Asp-Glu-Ala-Asp)	10521	NM_030881.2	1418.7298	1.3597	0	0
			box polypeptide 17
147	1400672	AMFR	autocrine motility factor	267	NM_001144.4	1425.012	1.2953	0	0
			receptor
148	6110747	GTMAP2	GIPase, IMAP family	26157	NM_015660.2	1433.7316	1.3711	0	0
			member 2
149	730379	LOC388621	—	388621	XM_941195.2	1434.8209	1.3642	0	0
150	870338	EGR1	early growth response 1	1958	NM_001964.2	1437.3716	0.8285	0	0
151	730528	PLAUR	plasminogen activator,	5329	NM_002659.2	1448.22	0.7926	0	0
			urokinase receptor
152	2060440	MAFB	v-maf musculoaponeurotic	9935	NM_005461.3	1451.0344	0.7939	1.00E−04	0
			fibrosarcoma oncogene
			homolog B (avian)
153	3140750	RBM38	RNA binding motif protein 38	55544	NM_183425.1	1459.9844	0.7692	1.00E−04	0
154	4490176	RGS1	regulator of G-protein	5996	NM_002922.3	1460.4038	1.0695	1.00E−04	0
			signaling 1
155	2370010	GZMH	granzyme H	2999	NM_033423.3	1464.3431	0.8085	1.00E−04	0
			(cathepsin G-like 2,
			protein h-CCPX)
156	7210035	SNORD13	small nucleolar	692084	NR_003041.1	1465.3176	0.8786	1.00E−04	0
			RNA, C/D box 13
157	780465	SLC11A1	solute carrier family 11	6556	NM_000578.3	1465.5854	0.7539	1.00E−04	0
			(proton-coupled
			divalent metal ion
			transporters), member 1
158	1410278	PF4V1	platelet factor 4 variant 1	5197	NM_002620.2	1467.1678	0.7455	1.00E−04	0
159	10224	METRNL	meteorin, glial	284207	XM_941466.2	1470.6115	0.7549	1.00E−04	0
			cell differentiation
			regulator-like
160	6840324	RPL13L	ribosomal protein L13-like	283345	NR_002803.1	1473.3493	1.3141	0	0
161	4760243	NULL	NULL	648210	XR_018923.1	1473.563	1.3236	0	0
162	2690390	HCG4	HLA complex group 4	54435	NR_002139.1	1483.3064	0.7057	1.00E−04	0
163	6130168	GSTM2	glutathione S-transferase mu 2	2946	NM_000848.2	1484.5662	1.1586	1.00E−04	0
			(muscle)
164	6650035	LOC338758	—	338758	XM_931359.2	1485.0079	0.786	1.00E−04	0
165	2710575	CD69	CD69 molecule	969	NM_001781.1	1492.1903	1.1581	1.00E−04	0
166	1030458	C19orf10	chromosome 19 open reading	56005	NM_019107.3	1495.2283	0.7531	1.00E−04	0
			frame 10
167	3990703	IL10	interleukin 10	3586	NM_000572.2	1496.2645	1.2881	1.00E−04	0
168	2230563	PPBP	pro-platelet basic protein	5473	NM_002704.2	1498.9534	0.8688	1.00E−04	0
			(chemokine (C—X—C motif)
			ligand 7)
169	5490768	GPR56	G protein-coupled receptor 56	9289	NM_201525.1	1502.85	0.9478	1.00E−04	0
170	4040576	IL6	interleukin 6	3569	NM_000600.1	1503.702	0.8304	1.00E−04	0
			(interferon, beta 2)
171	1850523	GZMB	granzyme B	3002	NM_004131.3	1505.0467	0.8201	1.00E−04	0
			(granzyme 2, cytotoxic
			T-lymphocyte-associated
			serine esterase 1)
172	1570553	IL8	interleukin 8	3576	NM_000584.2	1513.6436	1.115	1.00E−04	0
173	110332	NULL	NULL	NULL	XM_378421	1518.0403	1.3148	1.00E−04	0
174	4670193	PRF1	perforin 1	5551	NM_005041.4	1519.3926	0.8813	1.00E−04	0
			(pore forming protein)
175	5670605	MATK	megakaryocyte-associated	4145	NM_139354.2	1520.0412	0.81	1.00E−04	0
			tyrosine kinase
176	6650735	NULL	NULL	NULL	BCO20840	1525.1509	1.2826	1.00E−04	0
177	6510246	NULL	NULL	648210	XR_018923.1	1527.7265	1.3216	1.00E−04	0
178	1510681	NULL	NULL	440673	NM_001039703.1	1530.4662	0.7386	2.00E−04	0
179	6650161	GNA13	guanine nucleotide	10672	NM_006572.3	1532.1658	1.3018	1.00E−04	0
			binding protein
			(G protein), alpha 13
180	70162	TDG	thymine-DNA glycosylase	6996	NM_003211.3	1532.3669	0.7618	2.00E−04	0
181	6290114	SDPR	serum deprivation response	8436	NM_004657.4	1536.2237	0.7967	2.00E−04	0
			(phosphatidylserine
			binding protein)
182	3830242	NULL	NULL	642093	XM_942754.1	1537.7061	1.2013	1.00E−04	0
183	150609	LOC652493	—	652493	XM_941953.1	1538.659	0.8658	2.00E−04	0
184	1410221	S100A12	S100 calcium binding	6283	NM_005621.1	1538.9825	1.2033	1.00E−04	0
			protein A12
185	1030333	CCL2	chemokine (C-C motif)	6347	NM_002982.3	1539.4369	1.0091	2.00E−04	0
			ligand 2
186	7000356	RXRA	retinoid X receptor, alpha	6256	NM_002957.3	1541.9695	0.7849	2.00E−04	0
187	4610129	RETN	resistin	56729	NM_020415.2	1542.2649	0.9579	1.00E−04	0
188	290687	LOC653884	—	653884	XM_936240.1	1544.2074	0.7447	2.00E−04	0
189	6280332	CXCL16	chemokine (C—X—C motif)	58191	NM_022059.1	1546.842	0.7614	2.00E−04	0
			ligand 16
190	6860347	FAM46C	family with sequence	54855	NM_017709.3	1546.9813	0.8189	2.00E−04	0
			similarity 46, member C
191	3890326	SOD2	superoxide dismutase 2,	6648	NM_001024465.1	1548.2034	0.8086	2.00E−04	0
			mitochondrial
192	940398	EIF3M	eukaryotic translation	10480	NM_006360.3	1548.6574	1.3154	2.00E−04	0
			initiation factor 3,
			subunit M
193	5700070	ALPL	alkaline phosphatase,	249	NM_000478.3	1554.899	0.8918	2.00E−04	0
			liver/bone/kidney
194	3940438	NCF1	neutrophil cytosolic factor 1	653361	NM_000265.4	1557.7407	0.7547	2.00E−04	0
195	2900328	PTPLAD2	protein tyrosine	401494	NM_001010915.1	1561.8011	1.2964	2.00E−04	0
			phosphatase-like A
			domain containing 2
196	3930537	NULL	NULL	NULL	M97723	1563.1544	1.2251	2.00E−04	0
197	3060040	PABPC1	poly(A) binding protein,	26986	NM_002568.3	1573.2119	1.3135	2.00E−04	0
			cytoplasmic 1
198	3870338	IFI44L	interferon-induced protein	10964	NM_006820.1	1574.4975	0.7976	2.00E−04	0
			44-like
199	3840564	MS4A7	membrane-spanning	58475	NM_206938.1	1576.6213	0.7676	2.00E−04	0
			4-domains,
			subfamily A, member 7
200	3370201	LOC648343	—	648343	XR_018327.1	1584.6649	1.2593	2.00E−04	0
201	6280504	LOC100008589	—	100008589	NR_003287.1	1584.9019	0.8501	2.00E−04	0
202	7200435	ASCL2	achaete-scute complex	430	NM_005170.2	1588.1072	0.7612	2.00E−04	0
			homolog 2
			(Drosophila)
203	7050326	CDKN2D	cyclin-dependent	1032	NM_079421.2	1592.7956	0.771	2.00E−04	0
			kinase inhibitor
			2D (p19, inhibits CDK4)
204	7320561	OAS2	2′-5′-oligoadenylate	4939	NM_016817.2	1592.8459	0.782	2.00E−04	0
			synthetase 2, 69/71 kDa
205	2640088	ALDOA	aldolase A,	226	NM_184041.1	1601.3395	0.7836	2.00E−04	0
			fructose-bisphosphate
206	6380079	FAM53B	family with sequence	9679	NM_014661.3	1601.8988	0.7927	2.00E−04	0
			similarity 53, member B
207	6590446	NULL	NULL	651149	XM_940278.1	1603.0262	1.1689	2.00E−04	0
208	5050541	RPL15P3	ribosomal protein	653232	XM_944104.2	1610.6217	1.2836	2.00E−04	0
			L15 pseudogene 3
209	6620136	MYH9	myosin, heavy chain 9,	4627	NM_002473.3	1611.8118	0.7916	2.00E−04	0
			non-muscle
210	2340743	CPA3	carboxypeptidase A3	1359	NM_001870.1	1617.7401	1.2372	2.00E−04	0
			(mast cell)
211	6400392	GSTM1	glutathione S-transferase mu 1	2944	NM_000561.2	1618.8346	1.1278	2.00E−04	0
212	1030348	CDKN1B	cyclin-dependent kinase	1027	NM_004064.2	1622.318	1.2788	2.00E−04	0
			inhibitor 1B (p27, Kip1)
213	130717	ARPC1B	actin related protein 2/3	10095	NM_005720.2	1622.3622	0.7728	2.00E−04	0
			complex, subunit 1B, 41 kDa
214	3420373	SOD2	superoxide dismutase 2,	6648	NM_001024466.1	1623.9115	0.8404	2.00E−04	0
			mitochondrial
215	7320424	HNRPA1L-2	—	664709	NR_002944.2	1627.4854	1.3497	2.00E−04	0
216	830356	SLC4A5	solute carrier family 4,	57835	NM_133478.2	1629.4592	1.2662	3.00E−04	0
			sodium bicarbonate
			cotransporter, member 5
217	1240450	CD27	CD27 molecule	939	NM_001242.4	1630.1171	1.2929	3.00E−04	0
218	520408	IFIT3	interferon-induced protein	3437	NM_001549.2	1636.6346	0.7611	2.00E−04	0
			with tetratricopeptide
			repeats 3
219	5420095	MYC	v-myc myelocytomatosis viral	4609	NM_002467.3	1636.6524	1.3042	3.00E−04	0
			oncogene homolog (avian)
220	7510253	ACRBP	acrosin binding protein	84519	NM_032489.2	1637.0001	0.7754	2.00E−04	0
221	520392	P2RY13	purinergic receptor P2Y,	53829	NM_023914.2	1637.1533	0.7731	2.00E−04	0
			G-protein coupled, 13
222	70630	RNF144B	ring finger protein 144B	255488	NM_182757.2	1637.3458	0.7382	2.00E−04	0
223	5360273	SNCA	synuclein, alpha	6622	NM_007308.1	1637.8283	0.8495	2.00E−04	0
			(non A4 component
			of amyloid precursor)
224	1690706	HIST1H3H	histone cluster 1, H3h	8357	NM_003536.2	1645.7986	0.7667	3.00E−04	0
225	7560593	OSM	oncostatin M	5008	NM_020530.3	1647.1147	0.8196	3.00E−04	0
226	770167	CD79B	CD79b molecule,	974	NM_001039933.1	1648.4831	1.2138	3.00E−04	0
			immunoglobulin-
			associated beta
227	1010035	NLRP3	NLR family, pyrin domain	114548	NM_004895.3	1648.7639	0.8612	3.00E−04	0
			containing 3
228	2710451	NULL	NULL	651894	XM_941155.2	1649.6418	1.2523	3.00E−04	0
229	2260551	RAD21	RAD21 homolog (S. pombe)	5885	NM_006265.1	1653.0804	1.2801	3.00E−04	0
230	5670465	ADM	adrenomedullin	133	NM_001124.1	1655.0659	0.7829	3.00E−04	0
231	6420446	CMPK1	cytidine monophosphate	51727	NM_016308.1	1656.035	1.3183	3.00E−04	0
			(UMP-CMP) kinase 1,
			cytosolic
232	4260372	GTSCR1	Gilles de la Tourette	220158	XM_496277.2	1659.3612	1.26	3.00E−04	0
			syndrome chromosome
			region, candidate 1
233	2490450	hCG_1992539	—	91561	XM_934176.1	1661.3741	1.2023	3.00E−04	0
234	4040170	HBQ1	hemoglobin, theta 1	3049	NM_005331.3	1662.4015	0.8109	3.00E−04	0
235	870202	TNFSF10	tumor necrosis factor (ligand)	8743	NM_003810.2	1663.4194	0.8562	3.00E−04	0
			superfamily, member 10
236	1980594	FTHL8	ferritin, heavy	2501	NR_002203.1	1668.0712	1.1674	3.00E−04	0
			polypeptide-like 8
237	2370041	LRRN3	leucine rich repeat neuronal 3	54674	NM_018334.3	1672.3412	1.3042	3.00E−04	0
238	4220110	NULL	NULL	647450	XM_936518.1	1672.5458	0.8791	3.00E−04	0
239	1510612	MYL4	myosin, light chain 4, alkali;	4635	NM_002476.2	1681.4977	0.7979	4.00E−04	0
			atrial, embryonic
240	4010139	BANK1	B-cell scaffold protein	55024	NM_001083907.1	1683.3115	1.2158	4.00E−04	0
			with ankyrin repeats 1
241	5090215	IFI6	interferon, alpha-inducible	2537	NM_022873.2	1690.3545	0.818	4.00E−04	0
			protein 6
242	620717	CCL5	chemokine (C-C motif)	6352	NM_002985.2	1691.5746	0.812	4.00E−04	0
			ligand 5
243	4610681	LOC653658	—	653658	XM_939687.2	1693.2132	1.3052	4.00E−04	0
244	4290349	LOC643949	—	643949	XR_018645.1	1695.2143	1.2653	4.00E−04	0
245	450615	MT2A	metallothionein 2A	4502	NM_005953.2	1696.9888	0.7903	4.00E−04	0
246	1110373	C15orf48	chromosome 15 open	84419	NM_032413.2	1702.1009	0.946	4.00E−04	0
			reading frame 48
247	6400243	ABLIM1	actin binding LIM protein 1	3983	NM_001003407.1	1703.3875	1.2737	4.00E−04	0
248	6560279	VAV3	vav 3 guanine nucleotide	10451	NM_006113.4	1704.7097	1.0099	4.00E−04	0
			exchange factor
249	3940504	CD79A	CD79a molecule,	973	NM_021601.3	1705.1684	1.136	4.00E−04	0
			immunoglobulin-
			associated alpha
250	6510072	ACTG1	actin, gamma 1	71	NM_001614.2	1705.2256	0.8476	4.00E−04	0
251	610524	CCL3L1	chemokine (C-C motif)	6349	NM_021006.4	1713.0407	1.1746	4.00E−04	0
			ligand 3-like 1
252	6590646	FAM26F	family with sequence	441168	NM_001010919.1	1714.9816	1.2875	5.00E−04	0
			similarity 26, member F
253	3830136	NACAP1	nascent-polypeptide-	83955	NR_002182.1	1716.7585	1.3074	5.00E−04	0
			associated complex
			alpha polypeptide
			pseudogene 1
254	7650220	hCG_1787519	—	643007	XM_938089.2	1718.0255	1.2797	5.00E−04	0
255	1070477	ALDH1A1	aldehyde dehydrogenase 1	216	NM_000689.3	1718.8928	1.2672	5.00E−04	0
			family, member A1
256	6510754	ALDH1A1	aldehyde dehydrogenase 1	216	NM_000689.3	1720.5388	1.2203	5.00E−04	0
			family, member A1
257	3930008	RPL14	ribosomal protein L14	9045	NM_001034996.1	1720.6296	1.0405	5.00E−04	0
258	840551	CEP27	centrosomal protein 27 kDa	55142	NM_018097.1	1724.7797	1.2511	5.00E−04	0
259	5050402	HIST1H2BK	histone cluster 1, H2bk	85236	NM_080593.1	1726.2525	0.7687	5.00E−04	0
260	4920228	FFAR2	free fatty acid receptor 2	2867	NM_005306.1	1726.9269	0.8449	5.00E−04	0
261	3400521	NULL	NULL	653086	XM_930995.1	1728.9741	1.249	5.00E−04	0
262	4890241	GPR56	G protein-coupled receptor 56	9289	NM_201524.1	1730.7855	0.9285	5.00E−04	0
263	6280446	NULL	NULL	642989	XM_926370.1	1731.2064	1.2277	5.00E−04	0
264	2030132	LOC653506	—	653506	XM_927769.1	1732.6509	0.8096	5.00E−04	0
265	3310538	CD36	CD36 molecule	948	NM_000072.2	1732.7017	1.2213	5.00E−04	0
			(thrombospondin
			receptor)
266	2640025	HP	haptoglobin	3240	NM_005143.2	1733.6315	0.7543	5.00E−04	0
267	1940047	AIF1	allograft inflammatory	199	NM_001623.3	1734.8998	0.7781	5.00E−04	0
			factor 1
268	5690671	GOLGA8B	golgi autoantigen, golgin	440270	NM_001023567.2	1735.7582	1.2537	5.00E−04	0
			subfamily a, 8B
269	2470601	IL1RN	interleukin 1 receptor	3557	NM_173842.1	1736.4413	0.8188	5.00E−04	0
			antagonist
270	4150201	BCL2	B-cell CLL/lymphoma 2	596	NM_000633.2	1737.2395	1.2312	5.00E−04	0
271	6580059	UCP2	uncoupling protein 2	7351	NM_003355.2	1738.6131	1.2387	5.00E−04	0
			(mitochondrial,
			proton carrier)
272	3180131	hCG_1984468	—	389672	XM_933893.1	1749.2716	1.3078	5.00E−04	0
273	1770273	ANKRD30B	ankyrin repeat domain 30B	374860	NM_001029862.1	1750.2072	1.2567	5.00E−04	0
274	6450102	NULL	NULL	642113	XM_936253.1	1754.1531	0.9366	6.00E−04	0
275	1340743	IL8	interleukin 8	3576	NM_000584.2	1754.2793	1.148	5.00E−04	0
276	6620292	C10orf54	chromosome 10 open	64115	NM_022153.1	1755.4366	0.7563	6.00E−04	0
			reading frame 54
277	2570358	HNRPDL	heterogeneous nuclear	9987	NM_031372.1	1756.6323	1.304	6.00E−04	0
			ribonucleoprotein D-like
278	510209	LOC643310	—	643310	XM_926656.1	1756.8922	1.3155	6.00E−04	0
279	1770603	TCN1	transcobalamin I (vitamin B12	6947	NM_001062.3	1757.6057	1.1103	6.00E−04	0
			binding protein,
			R binder family)
280	1440121	tcag7.1261	—	645968	XM_928934.1	1759.0714	1.2841	6.00E−04	0
281	160242	C13orf15	chromosome 13 open	28984	NM_014059.2	1764.5447	1.1056	6.00E−04	0
			reading frame 15
282	4200541	FAM113B	family with sequence	91523	NM_138371.1	1768.2475	1.2217	6.00E−04	0
			similarity 113, member B
283	990500	AVPI1	arginine	60370	NM_021732.1	1770.8805	0.8357	7.00E−04	0
			vasopressin-induced 1
284	1440605	ZNF101	zinc finger protein 101	94039	NM_033204.2	1771.8967	1.2622	6.00E−04	0
285	2230167	LOC653773	—	653773	XM_938755.2	1772.9624	1.2915	6.00E−04	0
286	10358	SPN	sialophorin	6693	NM_001030288.1	1772.9705	0.7869	7.00E−04	0
287	7150711	ZNF223	zinc finger protein 223	7766	NM_013361.3	1775.2142	1.2356	6.00E−04	0
288	3420154	NLRP3	NLR family, pyrin domain	114548	NM_001079821.1	1778.0983	0.8935	7.00E−04	0
			containing 3
289	1710630	ST6GAL1	ST6 beta-galactosamide	6480	NM_003032.2	1778.5828	1.224	6.00E−04	0
			alpha-2,6-sialyltranferase 1
290	5360064	GNLY	granulysin	10578	NM_012483.1	1786.0213	0.8506	7.00E−04	0
291	1500201	HNRNPC	heterogeneous nuclear	3183	NM_031314.1	1788.8391	1.3177	7.00E−04	0
			ribonucleoprotein C (C1/C2)
292	6020523	PPP2R2B	protein phosphatase 2	5521	NM_181676.1	1795.9286	0.8076	8.00E−04	0
			(formerly 2A), regulatory
			subunit B, beta
			isoform
293	6280008	HSD17B11	hydroxysteroid (17-beta)	51170	NM_016245.3	1796.2197	1.2755	7.00E−04	0
			dehydrogenase 11
294	3780193	FCRLA	Fc receptor-like A	84824	NM_032738.3	1801.0361	1.1008	7.00E−04	0
295	580706	CCR2	chemokine (C-C motif)	1231	NM_000647.4	1810.4502	1.0875	8.00E−04	0
			receptor 2
296	7510386	IL1RN	interleukin 1 receptor	3557	NM_173843.1	1813.3956	0.9866	8.00E−04	0
			antagonist
297	1230767	IFITM2	interferon induced	10581	NM_006435.2	1814.7255	0.7643	8.00E−04	0
			transmembrane
			protein 2 (1-8D)
298	460164	FTHL11	ferritin, heavy	2503	NR_002204.1	1816.8226	1.1796	8.00E−04	0
			polypeptide-like 11
299	4150100	PASK	PAS domain containing	23178	NM_015148.2	1817.7821	1.1603	8.00E−04	0
			serine/threonine kinase
300	4050491	TCEA3	transcription elongation	6920	NM_003196.1	1817.9245	1.2597	8.00E−04	0
			factor A (SII), 3

TABLE 5
List of top 300 genes selected by Spearman's rank correlation coefficient.
Spearman
No.	Probe ID	Name of gene	Description of gene	EntrezID	Acc	limma_logFC	Cor_Spearman_R	Cor_Spearman_absR	Cor_Spearman_Pval	Cor_Spearman_adPval
1	1300687	NULL	NULL	731950	XR_016039.1	−0.061135983	0.700750469	0.700750469	1.25E−06	0.0212
2	2710653	FBXO38	F-box protein 38	81545	NM_030793.3	−0.149047116	0.660225141	0.660225141	6.35E−06	0.037
3	5860465	USP9Y	“ubiquitin specific peptidase 9, Y-	8287	NM_004654.3	−0.094524102	0.654409006	0.654409006	8.00E−06	0.037
			linked (fat facets-like,
			Drosophila)”
4	3390368	PDP2	—	57546	NM_020786.1	0.068777448	−0.652345216	0.652345216	8.72E−06	0.037
5	3130477	C7orf28A	chromosome 7 open reading frame	51622	XM_001133729.1	−0.383441629	0.634521576	0.634521576	1.73E−05	0.0392
			28A
6	1780719	PTGES3	prostaglandin E synthase 3	10728	NM_006601.4	−0.528677962	0.633395872	0.633395872	1.80E−05	0.0392
			(cytosolic)
7	6760017	YY1	YY1 transcription factor	7528	NM_003403.3	−0.328869705	0.630393996	0.630393996	2.02E−05	0.0392
8	270544	NR2C1	“nuclear receptor subfamily 2,	7181	NM_003297.1	−0.155303368	0.626641651	0.626641651	2.32E−05	0.0392
			group C, member 1”
9	5960072	NULL	NULL	NULL	BY797688	−0.097047292	0.626266417	0.626266417	2.35E−05	0.0392
10	2650601	GPBP1L1	GC-rich promoter binding protein	60313	NM_021639.3	−0.185092124	0.623827392	0.623827392	2.58E−05	0.0392
			1-like 1
11	6420446	CMPK1	“oytidine monophosphate (UMP-	51727	NM_016308.1	−0.398631213	0.622514071	0.622514071	2.70E−05	0.0392
			CMP) kinase 1, cytosolic”
12	7510379	SACS	spastic ataxia of Charlevoix-	26278	NM_014363.3	−0.121241812	0.621388368	0.621388368	2.82E−05	0.0392
			Saguenay (sacsin)
13	3130296	AMY2A	“amylase, alpha 2A (pancreatic)”	279	NM_000699.2	−0.282794372	0.616510319	0.616510319	3.36E−05	0.0392
14	520706	UBE4A	“ubiquitination factor E4A (UFD2	9354	NM_004788.2	−0.230502672	0.614258912	0.614258912	3.64E−05	0.0392
			homolog, yeast)”
15	1230593	SP3	Sp3 transcription factor	6670	NM_001017371.3	−0.175703429	0.613883677	0.613883677	3.69E−05	0.0392
16	2120017	NOL8	nucleolar protein 8	55035	NM_017948.4	−0.189491166	0.612945591	0.612945591	3.82E−05	0.0392
17	990315	TCP1	t-complex 1	6950	NM_030752.2	−0.256767834	0.612195122	0.612195122	3.92E−05	0.0392
18	730288	COG3	component of oligomeric golgi	83548	NM_031431.2	−0.128112796	0.606941839	0.606941839	4.72E−05	0.0408
			complex 3
19	150672	KLHL7	kelch-like 7 (Drosophila)	55975	NM_001031710.1	−0.155913324	0.605816135	0.605816135	4.91E−05	0.0408
20	6590484	NAP1L1	nucleosome assembly protein	4673	NM_139207.1	−0.357418466	0.605253283	0.605253283	5.01E−05	0.0408
			1-like 1
21	770441	DOPEY1	dopey family member 1	23033	NM_015018.2	−0.10084509	0.604878049	0.604878049	5.07E−05	0.0408
22	990044	KIAA1147	KIAA1147	57189	XM_001130020.1	−0.162506963	0.601125704	0.601125704	5.78E−05	0.0408
23	3120075	TIA1	TIA1 cytotoxic granule-associated	7072	NM_022173.1	−0.154497679	0.600375235	0.600375235	5.93E−05	0.0408
			RNA binding protein
24	4830255	DPP4	dipeptidyl-peptidase 4	1803	NM_001935.3	−0.307400655	0.599249531	0.599249531	6.16E−05	0.0408
25	4880521	CDC16	cell division cycle 16 homolog	8881	NM_003903.3	−0.34380491	0.598499062	0.598499062	6.32E−05	0.0408
			(S. cerevisiae)
26	150706	UGP2	UDP-glucose pyrophosphorylase 2	7360	NM_006759.3	−0.347146055	0.597560976	0.597560976	6.53E−05	0.0408
27	1780709	DDX17	DEAD (Asp-Glu-Ala-Asp) box	10521	NM_030881.2	−0.443292451	0.596998124	0.596998124	6.66E−05	0.0408
			polypeptide 17
28	1400240	LDHB	lactate dehydrogenase B	3945	NM_002300.4	−0.605485777	0.596622889	0.596622889	6.74E−05	0.0408
29	6180497	GOLGA8C	“golgi autoantigen, golgin	400304	XM_375152.3	−0.242008817	0.594559099	0.594559099	7.23E−05	0.0423
		a, 8C”	subfamily
30	5900129	CROP	—	51747	NM_006107.2	−0.443849065	0.593433396	0.593433396	7.51E−05	0.0425
31	4570170	KIAA0947	—	23379	NM_015325.1	−0.180354486	0.590243902	0.590243902	8.35E−05	0.0446
32	5720300	G3BP1	GTPase activating protein (SH3	10146	NM_005754.2	−0.241645343	0.590056285	0.590056285	8.41E−05	0.0446
			domain) binding protein 1
33	1110102	HS2ST1	heparan sulfate 2-O-	9653	NM_012262.2	−0.075582168	0.587992495	0.587992495	9.00E−05	0.0463
			sulfotransferase 1
34	2640025	HP	haptoglobin	3240	NM_005143.2	0.40681683	−0.585553471	0.585553471	9.79E−05	0.0476
35	6020575	NNT	nicotinamide nucleotide	23530	NM_012343.3	−0.191702435	0.584803002	0.584803002	0.000100019	0.0476
			transhydrogenase
36	7400376	RABL2A	“RAB, member of RAS oncogene	11159	NM_013412.1	−0.178370764	0.58424015	0.58424015	0.000101881	0.0476
			family-like 2A”
37	4220731	P4HA1	“prolyl 4-hydroxylase, alpha	5033	NM_000917.2	−0.307837835	0.583677298	0.583677298	0.000103774	0.0476
			polypeptide 1”
38	1110091	TIAL1	TIA1 cytotoxic granule-associated	7073	NM_001033925.1	−0.233908998	0.581425891	0.581425891	0.000111672	0.0486
			RNA binding protein-like 1
39	670209	ZNF700	zinc finger protein 700	90592	NM_144566.1	−0.134476397	0.581425891	0.581425891	0.000111672	0.0486
40	3930561	PRKC1	“protein kinase C, iota”	5584	NM_002740.5	−0.105841727	0.577298311	0.577298311	0.000127583	0.0538
41	4880463	SEC24A	“SEC24 family, member A	10802	NM_021982.1	−0.069649892	0.57673546	0.57673546	0.000129906	0.0538
			(S. cerevisiae)”
42	450195	Sept7	septin 7	989	NM_001788.4	−0.31815245	0.573921201	0.573921201	0.000142102	0.0538
43	7000521	PRPS2	phosphoribosyl pyrophosphate	5634	NM_001039091.1	−0.203904286	0.573733583	0.573733583	0.000142951	0.0538
			synthetase 2
44	3130370	ZNF83	zinc finger protein 83	55769	NM_018300.2	−0.30567958	0.573170732	0.573170732	0.000145525	0.0538
45	6650056	ZNF566	zinc finger protein 566	84924	NM_032838.2	−0.051770571	0.573170732	0.573170732	0.000145525	0.0538
46	240463	RNF216L	ring finger protein 216-like	441191	XR_001271.1	0.162378967	−0.572795497	0.572795497	0.000147702	0.0538
47	5900731	SFRS12	“splicing factor, arginine/serine-	140890	NM_001077199.1	−0.290167988	0.572420263	0.572420263	0.000149023	0.0538
			rich 12”
48	1740136	SLC38A2	“solute carrier family 38, member	54407	NM_018976.3	−0.214673013	0.568105066	0.568105066	0.000170654	0.0603
			2”
49	6280521	NULL	NULL	648399	XM_937448.1	−0.092941768	0.567354597	0.567354597	0.000174694	0.0605
50	840358	EXOSC10	exosome component 10	5394	NM_002685.2	−0.226165883	0.565853659	0.565853659	0.000183034	0.0609
51	5360719	MAPK9	mitogen-activated protein kinase 9	5601	NM_002752.3	−0.123212945	0.565853659	0.565853659	0.000183034	0.0609
52	1090892	GPBP1	GC-rich promoter binding	65056	NM_022913.1	−0.264875927	0.564165103	0.564165103	0.000192846	0.0623
			protein 1
53	6380673	TUBE1	“tubulin, epsilon 1”	51175	NM_016262.3	−0.138726153	0.563602251	0.563602251	0.00019622	0.0623
54	2570132	CLEC2D	“C-type lectin domain family 2,	29121	NM_001004419.2	−0.163087579	0.563227017	0.563227017	0.0001985	0.0623
			member D”
55	3990608	MAN2A1	“mannosidase, alpha, class 2A,	4124	NM_002372.2	−0.327379686	0.562288931	0.562288931	0.000204303	0.0623
			member 1”
56	4670605	MGC40489	—	146880	XR_016048.1	−0.029223716	0.562101313	0.562101313	0.000205482	0.0623
57	4830605	NULL	NULL	NULL	AV735490	−0.046858933	0.560037523	0.560037523	0.000218863	0.0652
58	6940176	ACTR3	ARP3 actin-related protein 3	10096	NM_005721.3	−0.459963089	0.556097561	0.556097561	0.000246612	0.0721
			homolog (yeast)
59	5560465	NOP56	NOP56 ribonucleoprotein homolog	10528	NM_006392.2	−0.266935568	0.553095685	0.553095685	0.000269844	0.0768
			(yeast)
60	7000474	GARNL1	GTPase activating Rap/RanGAP	253959	NM_194301.2	−0.175348366	0.55272045	0.55272045	0.000272883	0.0768
			domain-like 1
61	4850735	TAF4B	“TAF4b RNA polymerase II,	6875	NM_005640.1	−0.058542324	0.552345216	0.552345216	0.000275952	0.0768
			TATA box binding protein (TBP)-
			associated factor, 105 kDa”
62	3800707	XPO4	exportin 4	64328	NM_022459.3	−0.217365077	0.551594747	0.551594747	0.000282185	0.077
63	3290669	SFRS12	“splicing factor, arginine/serine-	140890	NM_139168.2	−0.132873689	0.551031895	0.551031895	0.000286942	0.077
			rich 12”
64	6110630	HIST1H2BK	“histone cluster 1, H2bk”	85236	NM_080593.1	0.379122401	−0.550469043	0.550469043	0.000292583	0.077
65	5810619	TADA1L	“transcriptional adaptor 1 (HFI1	117143	NM_053053.2	−0.16203449	0.550093809	0.550093809	0.000295032	0.077
			homolog, yeast)-like”
66	510209	LOC643310	—	643310	XM_926856.1	−0.395581648	0.549530957	0.549530957	0.000299984	0.0771
67	6450437	NULL	NULL	NULL	BF445990	0.102742584	−0.545028143	0.545028143	0.000343313	0.0859
68	4050195	FAM10A4	“family with sequence similarity	145165	NR_002183.1	−0.370567771	0.544840525	0.544840525	0.000344253	0.0859
			10, member A4 pseudogene”
69	7380707	ZFAND1	“zinc finger, AN1-type domain 1”	79752	NM_024699.1	−0.254784176	0.544090056	0.544090056	0.000351858	0.0865
70	70128	NULL	NULL	NULL	AK123745	−0.051335734	0.543339587	0.543339587	0.000359613	0.0869
71	2030332	PTPN18	“protein tyrosine phosphatase,	26469	NM_014369.2	0.083763446	−0.541838649	0.541838649	0.000376607	0.0869
			non-receptor type 18 (brain-
			derived)”
72	6650594	ATP11B	“ATPase, class VI, type 11B”	23200	NM_014616.1	−0.252853775	0.541838649	0.541838649	0.000375587	0.0869
73	2120537	SPOCD1	SPOC domain containing 1	90853	NM_144569.4	0.09473433	−0.541838649	0.541838649	0.000376607	0.0869
74	6380768	EIF4E	eukaryotic translation initiation	1977	NM_001968.2	−0.084050702	0.540900563	0.540900563	0.000385893	0.0869
			factor 4E
75	6980253	PTPLB	“protein tyrosine phosphatase-like	201562	NM_198402.2	−0.336175973	0.540337711	0.540337711	0.000392197	0.0869
			(proline instead of catalytic
			arginine), member b”
76	6060553	RBP5	“retinol binding protein 5, cellular”	83758	NM_031491.1	0.051243739	−0.540337711	0.540337711	0.000393257	0.0869
77	60553	NDFIP1	Nedd4 family interacting protein 1	80762	NM_030571.2	−0.171766084	0.540150094	0.540150094	0.000394319	0.0869
78	4210129	ELOVL5	“ELOVL family member 5,	60481	NM_021814.3	−0.284710319	0.538836773	0.538836773	0.000409464	0.0891
			elongation of long chain fatty acids
			(FEN1/Elo2, SUR4/Elo3-like,
79	6760326	ZNF658	zinc finger protein 658	26149	NM_033160.4	−0.078993442	0.537898687	0.537898687	0.0004206	0.0903
80	3060040	PABPC1	“poly(A) binding protein,	26986	NM_002568.3	−0.393451244	0.537148218	0.537148218	0.000429704	0.0905
			cytoplasmic 1”
81	460386	PTMA	“prothymosin, alpha”	5757	NM_001099285.1	−0.590989351	0.5369606	0.5369606	0.000432007	0.0905
82	290128	NULL	NULL	643985	XM_927235.1	−0.048540479	0.536022514	0.536022514	0.000443691	0.0918
83	3310309	CCDC135	coiled-coil domain containing 135	84229	NM_032269.4	0.099558313	−0.535272045	0.535272045	0.000454449	0.0929
84	7400047	LOC388344	—	388344	XM_371023.4	−0.327727336	0.534521576	0.534521576	0.000462978	0.0935
85	6550750	ARMC8	armedillo repeat containing 8	25852	NM_014154.2	−0.087200394	0.533020638	0.533020638	0.000483014	0.095
86	2600204	SACM1L	SAC1 suppressor of actin	22908	NM_014016.2	−0.262966982	0.532457786	0.532457786	0.000490726	0.095
			mutations 1-like (yeast)
87	6620356	ARPP-19	—	10776	NM_006628.4	−0.261668585	0.532457786	0.532457786	0.000490726	0.095
88	3710465	C6orf211	chromosome 6 open reading frame	79624	NM_024573.1	−0.114858487	0.532270169	0.532270169	0.000493321	0.095
			211
89	6020048	LOC646103	—	646103	XM_377879.3	−0.029867018	0.531894934	0.531894934	0.000498548	0.095
90	4010632	LQK1	—	642946	XM_927142.1	0.072739876	−0.531332083	0.531332083	0.000507815	0.0957
91	2320577	SSR2	“signal sequence receptor, beta	6746	XM_945427.1	0.064320484	−0.530956848	0.530956848	0.00051318	0.0957
			(translocon-associated protein
			beta)”
92	1780639	LOC645355	—	645355	XM_932842.1	0.036028447	−0.530206379	0.530206379	0.000524062	0.0967
93	1850612	PARP2	poly (ADP-ribose) polymerase 2	10038	NM_005484.2	−0.097585163	0.528893058	0.528893058	0.000542187	0.0989
94	4220673	NULL	NULL	NULL	AA971450	0.072927449	−0.528517824	0.528517824	0.000549307	0.0992
95	2970196	DEFB125	“defensin, beta 125”	245938	NM_153325.2	0.07618092	−0.527204503	0.527204503	0.00056969	0.1018
96	2640274	ALDH5A1	“aldehyde dehydrogenase 5 family,	7915	NM_001080.3	−0.078301425	0.526266417	0.526266417	0.000583149	0.1031
			member A1”
97	4780767	FLJ40473	—	285226	XR_001031.1	−0.068012051	0.525891182	0.525891182	0.000589222	0.1031
98	4760243	NULL	NULL	648210	XR_018923.1	−0.404442095	0.52532833	0.52532833	0.000598437	0.1031
99	4540356	UFM1	ubiquitin-fold modifier 1	51569	NM_016617.1	−0.290998607	0.525140713	0.525140713	0.000601537	0.1031
100	2680440	NULL	NULL	NULL	BF338665	0.061724508	−0.523639775	0.523639775	0.000628477	0.1066
101	770021	PRKRA	“protein kinase, interferon-	8575	NM_003690.3	−0.229357783	0.522138837	0.522138837	0.000653139	0.1081
			inducible double stranded RNA
			dependent activator”
102	840064	LOC645489	—	645489	XM_928514.1	−0.199041088	0.52195122	0.52195122	0.000656492	0.1081
103	6650646	C4orf39	chromosome 4 open reading frame	152756	NM_153027.1	−0.056865183	0.52195122	0.52195122	0.000656492	0.1081
			39
104	7000754	AMY2B	“amylase, alpha 2B (pancreatic)”	280	NM_020978.3	−0.131806513	0.520825516	0.520825516	0.000676935	0.1095
105	6860148	SLC9A6	“solute carrier family 9	10479	NM_001042537.1	−0.17456976	0.520637899	0.520637899	0.000680398	0.1095
			(sodium/hydrogen exchanger),
			member 6”
106	7400343	STX2	syntaxin 2	2054	NM_001980.2	−0.258793675	0.520450281	0.520450281	0.000683875	0.1095
107	5420053	CCT6P1	“chaperonin containing TCP1,	643253	NR_003110.2	−0.281922881	0.519324578	0.519324578	0.000705079	0.1118
			subunit 6 (zeta) pseudogene 1”
108	6560162	TMED7	transmembrane emp24 protein	51014	NM_181836.3	−0.243305775	0.518949343	0.518949343	0.000712276	0.1119
			transport domain containing 7
109	1850300	TC2N	“tandem C2 domains, nuclear”	123036	NM_152332.3	−0.236871126	0.518198874	0.518198874	0.000726869	0.113
110	4150168	ARSA	arylsulfatase A	410	NM_000487.3	0.091560891	−0.51782364	0.51782364	0.000736124	0.113
111	6560161	NULL	NULL	NULL	BX111675	0.054993081	−0.517448405	0.517448405	0.000743605	0.113
112	1500465	AASS	aminoadipate-semialdehyde	10157	NM_005763.2	−0.034373234	0.516697936	0.516697936	0.000756858	0.113
			synthase
113	4250154	NULL	NULL	648749	XM_937834.2	−0.061658345	0.516510319	0.516510319	0.000760684	0.113
114	2750411	RGAG4	retrotransposon gag domain	340526	NM_001024455.2	0.0613934	−0.516135084	0.516135084	0.000770323	0.113
			containing 4
115	6420730	RPL9	ribosomal protein L9	6133	NM_001024921.2	−0.56653985	0.515947467	0.515947467	0.000772284	0.113
116	4180356	RBBP6	retinoblastoma binding protein 6	5930	NM_032626.5	−0.053093332	0.51575985	0.51575985	0.000776159	0.113
117	4150553	TAF13	“TAF13 RNA polymerase II,	6884	NM_005645.3	0.061312413	−0.515572233	0.515572233	0.000782035	0.113
			TATA box binding protein (TBP)-
			associated factor, 18 kDa”
118	3610521	PCDHGB6	“protocadherin gamma	56100	NM_018926.2	0.176789549	−0.515384615	0.515384615	0.000785974	0.113
			subfamily B, 6”
119	4180142	KIAA1370	KIAA1370	56204	NM_019600.1	−0.224539294	0.514834146	0.514634146	0.0007999	0.1139
120	6450538	TCERG1	transcription elongation regulator 1	10915	NM_006706.3	−0.153163323	0.514258912	0.514258912	0.000807957	0.1139
121	5310736	FAM162A	“family with sequence similarity	26365	NM_014367.3	−0.324511803	0.514071295	0.514071295	0.000812012	0.1139
			162, member A”
122	290687	LOC653084	—	653884	XM_936240.1	0.425268736	−0.513320826	0.513320826	0.000830488	0.1155
123	3710681	ARFGEF1	ADP-ribosylation factor guanine	10565	NM_006421.3	−0.094839399	0.512757974	0.512757974	0.000840913	0.116
			nucleotide-exchange factor
			1(brefeldin A-inhibited)
124	2000035	NULL	NULL	NULL	AL042883	0.08373784	−0.512382739	0.512382739	0.000851456	0.1165
125	7160767	RBBP4	retinoblastoma binding protein 4	5928	NM_005610.1	−0.101719082	0.510881801	0.510881801	0.000883795	0.12
126	2570358	HNRPDL	heterogeneous nuclear	9987	NM_031372.1	−0.382998221	0.509943715	0.509943715	0.000905959	0.122
			ribonucleoprotein D-like
127	4390576	DFFA	“DNA fragmentation factor,	1676	NM_213566.1	0.121909434	−0.50956848	0.50956848	0.000917226	0.1225
			45 kDa, alpha polypeptide”
128	1820528	PAPSS1	3′-phosphoadenosine 5′-	9061	NM_005443.4	−0.222706769	0.509005629	0.509005629	0.000928618	0.1231
			phosphosulfate synthase 1
129	6040379	ZBTB11	zinc finger and BTB domain	27107	NM_014415.2	−0.043557823	0.508067542	0.508067542	0.000951782	0.1235
			containing 11
130	160440	NULL	NULL	643389	XM_926721.1	−0.052401185	0.507879925	0.507879925	0.000956476	0.1235
131	1710646	C11orf63	chromosome 11 open reading	79864	NM_024806.2	−0.036113925	0.507692308	0.507692308	0.000961191	0.1235
			frame 63
132	3120537	GAB2	GRB2-associated binding protein 2	9846	NM_080491.1	0.113527825	−0.507317073	0.507317073	0.000973069	0.1235
133	4540138	NGB	neuroglobin	58157	NM_021257.3	0.062540263	−0.506941839	0.506941839	0.000982665	0.1235
134	5910131	PDE6H	“phosphodiesterase 6H, cGMP-	5149	NM_006205.1	0.060610886	−0.506754221	0.506754221	0.000987495	0.1235
			specific, cone, gamma”
135	6980286	RNF219	ring finger protein 219	79596	NM_024546.2	−0.105227382	0.506754221	0.506754221	0.000985077	0.1235
136	6650161	GNA13	“guanine nucleotide binding	10672	NM_006572.3	−0.380533537	0.506566604	0.506566604	0.000989917	0.1235
			protein (G protein), alpha 13”
137	6380747	ANKRD32	ankyrin repeat domain 32	84250	NM_032290.2	−0.104537188	0.505253283	0.505253283	0.001024398	0.1251
138	580014	C12orf43	chromosome 12 open reading	64897	NM_022895.1	−0.20852646	0.505065666	0.505065666	0.00102941	0.1251
			frame 43
139	3850180	CHCHD7	coiled-coil-helix-coiled-coil-helix	79145	NM_001011670.1	−0.119451503	0.505065666	0.505065666	0.00102941	0.1251
			domain containing 7
140	610367	HECA	headcase homolog (Drosophila)	51696	NM_016217.2	−0.312188665	0.504878049	0.504878049	0.001034444	0.1251
141	780402	RTN4	retioulon 4	57142	NM_020532.4	−0.274156562	0.504690432	0.504690432	0.0010395	0.1251
142	770128	L3MBTL3	l(3)mbt-like 3 (Drosophila)	84456	NM_032438.1	−0.161561418	0.503939962	0.503939962	0.001059945	0.1251
143	3780465	SMARCA5	“SWI/SNF related, matrix	8467	NM_003601.2	−0.115124978	0.503752345	0.503752345	0.001065112	0.1251
			associated, actin dependent
			regulator of chromatin, subfamily
			a.
144	5490603	hCG_1783417	—	401019	NM_001080831.1	−0.173305696	0.503752345	0.503752345	0.001065112	0.1251
145	4610138	CAPZA1	“capping protein (actin filament)	829	NM_006135.1	−0.36644329	0.503377111	0.503377111	0.001075513	0.1251
			muscle Z-line, alpha 1”
146	2450326	NULL	NULL	642047	XM_936157.1	0.047996723	−0.503377111	0.503377111	0.001078127	0.1251
147	6580064	C14orf19	chromosome 14 open reading	280655	NR_002937.1	−0.152106349	0.503001876	0.503001876	0.001086005	0.1251
			frame 19
148	7040524	FAM76A	“family with sequence similarity	199870	NM_152660.1	−0.052516764	0.502814259	0.502814259	0.001091285	0.1251
			76, member A”
149	6770634	USP8	ubiquitin specific peptidase 8	9101	NM_005154.2	−0.15261273	0.50206379	0.50206379	0.001112634	0.1253
150	2120468	C10orf58	chromosome 10 open reading	84293	NM_032333.2	−0.327354271	0.501876173	0.501876173	0.001118029	0.1253
			frame 58
151	2070019	UBA6	ubiquitin-like modifier activating	55236	NM_018227.5	−0.194843638	0.501688555	0.501688555	0.001123447	0.1253
			enzyme 6
152	5390433	DICER1	“dicer 1, ribonuclease type III”	23405	NM_030621.2	−0.111116126	0.501688555	0.501688555	0.001123447	0.1253
153	6450129	ITM2A	integral membrane protein 2A	9452	NM_004867.3	−0.126988076	0.501125704	0.501125704	0.001139843	0.1253
154	20288	Sept11	septin 11	55752	NM_018243.2	−0.136166131	0.500938086	0.500938086	0.001145356	0.1253
155	6370736	EIF1AX	“eukaryotic translation initiation	1964	NM_001412.3	−0.117614043	0.500375235	0.500375235	0.001162036	0.1253
			factor 1A, X-linked”
156	730379	LOC388621	—	388621	XM_941195.2	−0.448108038	0.500187617	0.500187617	0.001167644	0.1253
157	1500047	RIN1	Ras and Rab interactor 1	9610	NM_004292.2	0.132155916	−0.5	0.5	0.001176101	0.1253
158	5960594	PMS1	PMS1 postmeiotic segregation	5378	NM_000534.3	−0.077033315	0.5	0.5	0.001173276	0.1253
			increased 1 (S. cerevisiae)
159	4220114	NULL	NULL	NULL	DA160411	0.070349309	−0.499624765	0.499624765	0.001187461	0.1253
160	5910463	PKIA	“protein kinase (cAMP-dependent,	5569	NM_006823.2	−0.254561014	0.499437148	0.499437148	0.001190317	0.1253
			catalytic) inhibitor alpha”
161	1410170	GOPC	golgi associated PDZ and coiled-	57120	NM_020399.2	−0.088182858	0.498686679	0.498686679	0.001213381	0.1253
			coil motif containing
162	4780768	FAM8A1	“family with sequence similarity B,	51439	NM_016255.1	−0.099801523	0.498499062	0.498499062	0.001219209	0.1253
			member A1”
163	1580286	SEH1L	SEH1-like (S. cerevisiae)	81929	NM_031216.3	−0.083010039	0.498311445	0.498311445	0.001225062	0.1253
164	4570403	NULL	NULL	NULL	BX106581	0.112837902	−0.497748593	0.497748593	0.001245745	0.1253
165	5310747	PSIP1	PC4 and SFRS1 interacting	11168	NM_033222.2	−0.298779917	0.497748593	0.497748593	0.001242771	0.1253
			protein 1
166	460682	CCDC132	coiled-coil domain containing 132	55610	NM_017667.2	−0.123015026	0.497748593	0.497748593	0.001242771	0.1253
167	7550221	NULL	NULL	NULL	BG207842	0.067923939	−0.497748593	0.497748593	0.001245745	0.1253
168	3520601	MPO	myeloperoxidase	4353	NM_000250.1	0.96554979	−0.497373358	0.497373358	0.001257702	0.1253
169	2570725	PPCS	phosphopantothenoylcysteine	79717	NM_001077447.1	−0.310167811	0.497373358	0.497373358	0.001254703	0.1253
			synthetase
170	6200747	LOC220433	—	220433	XM_941684.2	−0.448374765	0.497185741	0.497185741	0.001260707	0.1253
171	3710682	NULL	NULL	642033	XM_936103.1	0.143366073	−0.496998124	0.496998124	0.001269761	0.1253
172	2100594	BUB3	budding uninhibited by	9184	NM_004725.2	−0.303162523	0.496247655	0.496247655	0.001291113	0.1253
			benzimidazoles 3 homolog (yeast)
173	2760605	MTMR1	myotubularin related protein 1	8776	NM_176789.1	−0.027175642	0.496247655	0.496247655	0.001291113	0.1253
174	6900768	NULL	NULL	NULL	DA572426	−0.08577853	0.49587242	0.49587242	0.001303457	0.1253
175	7150685	CBX5	“chromobox homolog 5 (HP1	23468	NM_012117.1	0.077258047	−0.495121951	0.495121951	0.001331616	0.1253
			alpha homolog, Drosophila)”
176	160047	LOC389787	—	389787	XM_497072.2	−0.49206406	0.495121951	0.495121951	0.00132846	0.1253
177	3830598	CARTPT	CART prepropeptide	9607	NM_004291.2	0.027959175	−0.495121951	0.495121951	0.001331616	0.1253
178	870040	ASCC3	activating signal cointegrator 1	10973	NM_006828.2	−0.10465835	0.494934334	0.494934334	0.001334777	0.1253
			complex subunit 3
179	2100292	RBBP7	retinoblastoma binding protein 7	5931	NM_002893.2	−0.173081269	0.494746717	0.494746717	0.001341121	0.1253
180	5860327	PRPF18	PRP18 pre-mRNA processing	8559	NM_003675.3	−0.26670234	0.494371482	0.494371482	0.001353889	0.1253
			factor 18 homolog (S. cerevisiae)
181	7560300	TCTEX1D1	Tctex1 domain containing 1	200132	NM_152665.1	0.124259481	−0.494183865	0.494183865	0.001363536	0.1253
182	5360619	CDC16	cell division cycle 16 homolog	8881	NM_001078645.1	−0.262987116	0.494183865	0.494183865	0.001360314	0.1253
			(S. cerevisiae)
183	3440189	ZBTB20	zinc finger and BTB domain	26137	NM_015642.3	−0.287117754	0.493996248	0.493996248	0.001366765	0.1253
			containing 20
184	940168	GTPBP8	GTP-binding protein 8 (putative)	29083	NM_014170.2	0.193620887	−0.493996248	0.493996248	0.001370001	0.1253
185	10142	CD164	“CD164 molecule, sialomucin”	8763	NM_006016.3	−0.14302977	0.493996248	0.493996248	0.001366765	0.1253
186	6020273	RPS4Y2	“ribosomal protein S4, Y-linked 2”	140032	NM_001039567.2	−0.29587893	0.49380863	0.49380863	0.001373244	0.1253
187	3990112	CAST	calpastatin	831	NM_001042445.1	−0.280052769	0.493058161	0.493058161	0.001399433	0.127
188	3120762	MSH5	mutS homolog 5 (E. coli)	4439	NM_002441.3	0.058093161	−0.492682927	0.492682927	0.001416025	0.1278
189	160537	KDSR	3-ketodihydrosphingosine	2531	NM_002035.1	−0.165230376	0.491932458	0.491932458	0.001439548	0.1292
			reductase
190	5290358	CPT1A	carnitine palmitoyltransferase 1A	1374	NM_001031847.1	0.165571989	−0.490994371	0.490994371	0.001477215	0.131
			(liver)
191	3440670	NULL	NULL	402251	XM_377933.3	−0.279019599	0.490994371	0.490994371	0.001473755	0.131
192	3370673	GUSBL2	“glucuronidase, beta-like 2”	375513	NM_206910.1	0.128073825	−0.490806754	0.490806754	0.001484157	0.131
193	4260767	GP1BA	“glycoprotein 1b (platelet), alpha	2811	NM_000173.4	0.13089936	−0.490243902	0.490243902	0.001505156	0.131
			polypeptide”
194	6550600	MYC	v-myc myelocytomatosis viral	4609	NM_002467.3	−0.337363684	0.489493433	0.489493433	0.001529989	0.131
			oncogene homolog (avian)
195	1740154	TMEM106B	transmembrane protein 106B	54664	NM_018374.2	−0.106689074	0.489493433	0.489493433	0.001529989	0.131
196	7160332	NULL	NULL	NULL	CF552427	0.054930882	−0.489305816	0.489305816	0.001540742	0.131
197	4010452	SLC38A6	“solute carrier family 38, member	145389	NM_153811.1	−0.136358094	0.489305816	0.489305816	0.00153715	0.131
			6”
198	510050	LOC652837	—	652837	XM_942529.1	−0.036184103	0.489305816	0.489305816	0.00153715	0.131
199	5720703	AKTIP	AKT interacting protein	64400	NM_022476.2	−0.132110131	0.489118199	0.489118199	0.001544342	0.131
200	380575	RPL23	ribosomal protein L23	9349	NM_000978.3	−0.338815803	0.489118199	0.489118199	0.001544342	0.131
201	1980626	SMARCA5	“SWI/SNF related, matrix	8467	NM_003601.2	−0.146115776	0.488742964	0.488742964	0.001558814	0.1316
			associated, actin dependent
			regulator of chromatin,
			subfamily a.
202	6110747	GIMAP2	“GTPase. IMAP family member 2”	26157	NM_015660.2	−0.45531031	0.488555347	0.488555347	0.001566095	0.1316
203	7380382	RNF115	ring finger protein 115	27246	NM_014455.1	0.278371033	−0.48836773	0.48836773	0.001577073	0.1318
204	6510619	NAE1	NEDD8 activating enzyme E1	8883	NM_001018160.1	−0.29276015	0.487992495	0.487992495	0.00158812	0.1321
			subunit 1
205	6110091	WSB1	WD repeat and SOCS box-	26118	NM_134265.2	−0.29256262	0.485928705	0.485928705	0.001671249	0.1376
			containing 1
206	2970296	ALG8	“asparagine-linked glycosylation 8,	79053	NM_001007027.2	−0.171596568	0.485928705	0.485928705	0.001671249	0.1376
			alpha-1,3-glucosyltransferase
			homolog (S. cerevisiae)”
207	7150554	LCOR	ligand dependent nuclear receptor	84458	NM_032440.1	−0.293176479	0.485741088	0.485741088	0.001678994	0.1376
			corepressor
208	6560609	CNOT8	“CCR4-NOT transcription	9337	NM_004779.4	−0.206326635	0.484990619	0.484990619	0.001710294	0.1395
			complex, subunit 8”
209	20091	GABARAPL2	GABA(A) receptor-associated	11345	NM_007285.6	−0.164409469	0.484615385	0.484615385	0.001726137	0.1395
			protein-like 2
210	2900112	PPIB	peptidylprolyl isomerase B	5479	NM_000942.4	−0.126826389	0.484615385	0.484615385	0.001726137	0.1395
			(cyclophilin B)
211	4730458	CLTC	“clathrin, heavy chain (Hc)”	1213	NM_004859.3	−0.126167554	0.483864916	0.483864916	0.001758214	0.1407
212	3140553	SAR1A	SAR1 homolog A (S. cerevisiae)	56681	NM_020150.3	−0.181453186	0.483677298	0.483677298	0.001766316	0.1407
213	5960561	DBR1	debranching enzyme homolog 1	51163	NM_016216.2	−0.051928612	0.483677298	0.483677298	0.001766316	0.1407
			(S. cerevisiae)
214	4050609	DNAJA2	“DnaJ (Hsp40) homolog,	10294	NM_005880.2	−0.266568167	0.483489681	0.483489681	0.00177445	0.1407
			subfamily A, member 2”
215	990543	SFRS11	“splicing factor, arginine/serine-	9295	NM_004768.2	−0.164426621	0.482926829	0.482926829	0.001799054	0.1408
			rich 11”
216	7570189	GAGE6	G antigen 6	2578	NM_001476.1	0.084017945	−0.482363977	0.482363977	0.001828139	0.1408
217	1500201	HNRNPC	heterogeneous nuclear	3183	NM_031314.1	−0.397999182	0.48217636	0.48217636	0.001832328	0.1408
			ribonucleoprotein C (C1/C2)
218	2760400	WDSOF1	WD repeate and SOF1 domain	25879	NM_015420.5	−0.059823595	0.481613508	0.481613508	0.00185764	0.1408
			containing
219	5820544	CTGLF1	“centaurin, gamma-like family,	119016	NM_133446.1	−0.040059562	0.481613508	0.481613508	0.00185764	0.1408
			member 1”
220	2680433	MOSPD1	motile sperm domain containing 1	56180	NM_019566.1	−0.042888816	0.481613508	0.481613508	0.00185764	0.1408
221	4260504	SNX14	sorting nexin 14	57231	NM_020468.2	−0.218109366	0.481425891	0.481425891	0.001866146	0.1408
222	5910543	GLOD4	glyoxalase domain containing 4	51031	NM_016080.2	−0.177207323	0.481238274	0.481238274	0.001874687	0.1408
223	840673	ZNF383	zinc finger protein 383	163087	NM_152604.1	−0.129968709	0.481238274	0.481238274	0.001874687	0.1408
224	5550711	SYNE1	“spectrin repeat containing, nuclear	23345	NM_182961.2	0.075512374	−0.481050657	0.481050657	0.001887563	0.1408
			envelope 1”
225	4760037	NULL	NULL	651648	XM_940853.1	−0.018758212	0.481050657	0.481050657	0.001883262	0.1408
226	5820202	LOC644131	—	644131	XR_018325.1	−0.244724622	0.480863039	0.480863039	0.001891872	0.1408
227	4730408	ANAPC5	anaphase promoting complex	51433	NM_016237.3	−0.212087146	0.480863039	0.480863039	0.001891872	0.1408
			subunit 5
228	3850008	NULL	NULL	654189	XM_942687.1	−0.093486403	0.480675422	0.480675422	0.001900517	0.1408
229	460333	SPAST	spastin	6683	NM_199436.1	−0.064545186	0.480675422	0.480675422	0.001900517	0.1408
230	1110192	PPM2C	“protein phosphatase 2C,	54704	NM_018444.2	−0.100238781	0.48011257	0.48011257	0.001926661	0.1421
			magnesium-dependent, catalytic
			subunit”
231	3520470	RBMXP3	“RNA binding motif protein, X-	143543	NR_002197.1	−0.129523594	0.479924953	0.479924953	0.001935447	0.1422
			linked pseudogene 3”
232	5900482	HMGB2	high-mobility group box 2	3148	NM_002129.2	−0.440289057	0.479174484	0.479174484	0.001970944	0.1442
233	2230300	ZNF561	zinc finger protein 561	93134	NM_152289.1	−0.059435926	0.47879925	0.47879925	0.001988907	0.1448
234	6280524	CCNL1	cyclin L1	57018	NM_020307.2	−0.186663803	0.476923077	0.476923077	0.002080918	0.1503
235	6650133	LSM5	“LSM5 homolog, U6 Small	23658	NM_012322.1	−0.157326463	0.476923077	0.476923077	0.002080918	0.1503
			nuclear RNA associated
			(S. cerevisiae)”
236	1170288	PRMT1	protein arginine	3276	NM_198319.2	0.067974089	−0.476172608	0.476172608	0.002123537	0.1518
			methyltransferase 1
237	7320424	HNRPA1L-2	—	664709	NR_002944.2	−0.432630765	0.475797373	0.475797373	0.002137913	0.1518
238	2070025	SAV1	salvador homolog 1 (Drosophila)	60485	NM_021818.2	−0.083084103	0.475797373	0.475797373	0.002137913	0.1518
239	3940333	ZNF266	zinc finger protein 266	10781	NM_006631.2	−0.108968593	0.475797373	0.475797373	0.002137913	0.1518
240	4810072	TUSC2	tumor suppressor candidate 2	11334	NM_007275.1	0.162628207	−0.475234522	0.475234522	0.002171795	0.1533
241	7610608	RP11-122C9.1	—	653702	NM_001093763.1	−0.316189323	0.475046904	0.475046904	0.002176674	0.1533
242	840601	MEGF10	multiple EGF-like-domains 10	84466	NM_032446.1	0.047723662	−0.474859287	0.474859287	0.002191368	0.1536
243	3870209	RTEL1	regulator of telomere elongation	51750	NM_032957.3	0.061308622	−0.474484053	0.474484053	0.002211097	0.1544
			helicase 1
244	4900343	MORF4L1	mortality factor 4 like 1	10933	NM_206839.1	−0.24904666	0.473921201	0.473921201	0.002235979	0.1552
245	6270433	hCG_1646420	—	644672	XM_938396.1	0.038585438	−0.473921201	0.473921201	0.002240985	0.1552
246	3780482	NULL	NULL	NULL	BQ011293	0.031282267	−0.473545966	0.473545966	0.002261108	0.1557
247	3190059	IMMT	“inner membrane protein,	10989	NM_001100169.1	−0.221779779	0.473358349	0.473358349	0.002266164	0.1557
			mitochondrial (mitofilin)”
248	5560703	C6orf120	chromosome 6 open reading frame	387263	NM_001029863.1	−0.109371386	0.472232645	0.472232645	0.002327616	0.1586
			120
249	7000672	AGL	“amylo-1, 6-glucosidase, 4-alpha-	178	NM_000642.2	−0.081394333	0.472232645	0.472232645	0.002327616	0.1586
			glucanotransferase”
250	6980326	ANP32C	“acidic (leucine-rich) nuclear	23520	NM_012403.1	−0.074417224	0.471669794	0.471669794	0.00235889	0.1589
			phosphoprotein 32 family, member
			C”
251	2640255	NULL	NULL	641848	XM_935588.1	−0.645965338	0.471482176	0.471482176	0.002369397	0.1589
252	2190390	NCOA1	nuclear receptor coactivator 1	8648	NM_147223.2	−0.208822548	0.471482176	0.471482176	0.002369397	0.1589
253	5360204	NMD3	NMD3 homolog (S. cerevisiae)	51068	NM_015938.3	−0.201253758	0.471482176	0.471482176	0.002369397	0.1589
254	4040242	FAM89A	“family with sequence similarity	375061	NM_198552.1	0.108042121	−0.471294559	0.471294559	0.002385235	0.1591
			89, member A”
255	2690561	RPLP1	“ribosomal protein, large, P1”	6176	NM_001003.2	−0.685558024	0.471106942	0.471106942	0.002390536	0.1591
256	3390286	ADRA2B	“adrenergic, alpha-2B-, receptor”	151	NM_000682.5	0.054174105	−0.470731707	0.470731707	0.002417192	0.1602
257	5960332	SLC39A10	“solute carrier family 39 (zinc	57181	NM_020342.1	−0.147299889	0.470168856	0.470168856	0.002444111	0.1608
			transporter), member 10”
258	7380068	CNBP	“CCHC-type zinc finger, nucleic	7555	NM_003418.1	−0.327720874	0.469981238	0.469981238	0.002454952	0.1608
			acid binding protein”
259	1820300	CTSO	cathepsin O	1519	NM_001334.2	−0.231977107	0.469981238	0.469981238	0.002454952	0.1608
260	6100170	NULL	NULL	NULL	AI004472	0.074355718	−0.469608004	0.469606004	0.002482242	0.1612
261	7610079	HSF2BP	heat shock transcription faotor 2	11077	NM_007031.1	−0.038423478	0.469606004	0.469606004	0.002476763	0.1612
			binding protein
262	6480600	THUMPD1	THUMP domain containing 1	55623	NM_017736.3	−0.123219301	0.469230769	0.469230769	0.002498744	0.1612
263	990528	DNAJC10	“DnaJ (Hsp40) homolog,	54431	NM_018981.1	−0.085780126	0.469230769	0.469230769	0.002498744	0.1612
			subfamily C, member 10”
264	4860066	NULL	NULL	647346	XM_936495.2	−0.209955699	0.468667917	0.468667917	0.002532038	0.1624
265	5050402	HIST1H2BK	“histone cluster 1, H2bk”	85236	NM_080593.1	0.379454337	−0.4684803	0.4684803	0.002548832	0.1624
266	7040482	LOC642934	—	642934	XM_942991.2	−0.452151346	0.4684803	0.4684803	0.002543223	0.1624
267	2060050	NULL	NULL	NULL	BM932227	−0.116682268	0.467917448	0.467917448	0.00257704	0.1624
268	6590278	CBX2	“chromobox homolog 2 (Pc class	84733	NM_005189.1	0.077041967	−0.467542214	0.467542214	0.002605523	0.1624
			homolog, Drosophila)”
269	60053	RPL11	ribosomal protein L11	6135	NM_000975.2	−0.156372832	0.467542214	0.467542214	0.002599804	0.1624
270	1820068	AMY1C	“amylase, alpha 1C (salivary)”	278	NM_001008219.1	−0.195378515	0.467542214	0.467542214	0.002599804	0.1624
271	430100	XRCC6	X-ray repair complementing	2547	NM_001469.3	−0.202101353	0.467354597	0.467354597	0.002611253	0.1624
			defective repair in Chinese hamster
			cells 6
272	520133	SUMO2	SMT3 suppressor of mif two 3	6613	NM_001005849.1	−0.316672366	0.467354597	0.467354597	0.002611253	0.1624
			homolog 2 (S. cerevisiae)
273	3060379	SEC14L1	SEC14-like 1 (S. cerevisiae)	6397	NM_003003.1	0.211393155	−0.467354597	0.467354597	0.002616994	0.1624
274	2760553	UBA3	ubiquitin-like modifier activating	9039	NM_198197.1	−0.187898967	0.467166979	0.467166979	0.002622746	0.1624
			enzyme 3
275	4540689	ANKRD10	ankyrin repeat domain 10	55608	NM_017664.2	−0.170575575	0.466791745	0.466791745	0.002645865	0.1624
276	7100519	CEP57	centrosomal protein 57 kDa	9702	NM_014679.3	−0.122048981	0.466604128	0.466604128	0.002657493	0.1624
277	4860431	NBPF14	“neuroblastoma breakpoint family,	25832	NM_015383.1	−0.189228519	0.46641651	0.46641651	0.002669165	0.1624
			member 14”
278	6110014	FUSIP1	FUS interacting protein	10772	NM_054016.1	0.343795227	−0.46641651	0.46641651	0.002675018	0.1624
			(serine/arginine-rich) 1
279	6250609	KPNA2	“karyopherin alpha 2 (RAG cohort	3838	NM_002266.2	−0.04951944	0.46641651	0.46641651	0.002669165	0.1624
			1, importin alpha 1)”
280	2360630	FDFT1	farnesyl-diphosphate	2222	NM_004462.3	−0.242595956	0.466041276	0.466041276	0.002692645	0.1624
			farnesyltransferase 1
281	6860673	NUS1	nuclear undecaprenyl	116150	NM_138459.3	−0.049044618	0.466041276	0.466041276	0.002692645	0.1624
			pyrophosphate synthase 1 homolog
			(S. cerevisiae)
282	6270674	RECQL	RecQ protein-like (DNA helicase	5965	NM_032941.1	−0.04289978	0.465853659	0.465853659	0.002704453	0.1624
			Q1-like)
283	6370435	ETS1	v-ets erythroblastosis virus E26	2113	NM_005238.2	−0.467750348	0.465666041	0.465666041	0.002716307	0.1624
			oncogene homolog 1 (avian)
284	270091	C19orf68	chromosome 19 open reading	374920	NM_199341.1	0.052642885	−0.465478424	0.465478424	0.002734174	0.1624
			frame 68
285	1050148	LOC653264	—	653264	XM_932721.2	−0.102751263	0.465478424	0.465478424	0.002728207	0.1624
286	3990563	IFNA10	“interferon, alpha 10”	3446	NM_002171.1	0.151388979	−0.465290807	0.465290807	0.002746142	0.1624
287	2690370	ZNF92	zinc finger protein 92	168374	NM_007139.2	−0.058140458	0.465290807	0.465290807	0.002740152	0.1624
288	2640551	CMPK1	“cytidine monophosphate (UMP-	51727	NM_016308.1	−0.272595837	0.464915572	0.464915572	0.002764182	0.1624
			CMP) kinase 1, cytosollc”
289	3830470	PLB1	phospholipase B1	151056	NM_153021.3	0.102166339	−0.464915572	0.464915572	0.002770218	0.1624
290	1940008	LOC644330	—	644330	XR_017492.1	−0.238139626	0.464727955	0.464727955	0.002776266	0.1624
291	3610348	FAM10A4	“family with sequence similarity	145165	NR_002183.1	−0.192448279	0.464540338	0.464540338	0.002788397	0.1626
			10, member A4 pseudogene”
292	6650672	ZNF439	zinc finger protein 439	90594	NM_152262.2	−0.168089512	0.464165103	0.464165103	0.002812798	0.1635
293	6590441	TRIP12	thyroid hormone receptor	9320	NM_004238.1	−0.196624966	0.463789869	0.463789869	0.002837388	0.1643
			interactor 12
294	3310372	NULL	NULL	NULL	AI066603	0.060736288	−0.463414634	0.463414634	0.002868392	0.1651
295	1740647	FAM180B	“family with sequence similarity	399888	XM_941808.2	0.083819707	−0.4630394	0.4630394	0.002893409	0.1651
			180, member B”
296	3870670	MED7	mediator complex subunit 7	9443	NM_004270.3	−0.059699888	0.4630394	0.4630394	0.002887137	0.1651
297	6940102	TNC	tenasoin C	3371	NM_002160.1	0.032850087	−0.4630394	0.4630394	0.002893409	0.1651
298	3940653	PREPL	prolyl endopeptidase-like	9581	NM_006036.2	−0.129916608	0.462664165	0.462664165	0.002912298	0.1651
299	1570292	NULL	NULL	NULL	AI807878	−0.087151047	0.462476548	0.462476548	0.002924951	0.1651
300	5890477	SNORA32	“small nucleolar RNA, H/ACA	692063	NR_003032.1	−0.085303112	0.462288931	0.462288931	0.002937652	0.1651
			box 32”

TABLE 6
Coefficients used for the prediction of survival time of each patient with the gene set consisting
of top 50 genes selected by Pearson product-moment correlation coefficient, latent variable 3.
ProbeID	S2_pre	S3_pre	S4_pre	S6_pre	S7_pre	S8_pre	L3_pre	L4_pre	L1_pre	S10_pre	S12_pre	S13_pre
3390368	−185	−188	−199	−198	−173	−185	−184	−184	−190	−187	−183	−189
1300687	127	134	118	138	138	130	130	131	135	128	130	134
5860465	38	35	45	33	32	37	34	31	35	32	32	28
4390576	−348	−362	−360	−383	−349	−345	−354	−350	−366	−362	−354	−365
4830255	185	201	184	208	174	206	186	177	186	202	190	182
4570403	−406	−422	−427	−449	−416	−423	−415	−410	−422	−433	−410	−432
1780719	33	69	−21	74	32	27	59	64	70	33	65	65
3130477	−34	−41	−45	−49	−84	−62	−53	−31	−51	−79	−45	−55
6110630	−478	−476	−513	−525	−493	−476	−469	−473	−446	−508	−460	−454
3310309	−344	−350	−340	−366	−352	−335	−342	−337	−363	−351	−334	−346
4220731	137	146	224	170	140	157	153	167	149	151	158	173
520706	46	47	71	53	83	72	46	42	56	38	45	55
6420446	−57	−80	−87	−74	−62	−73	−77	−86	−68	−116	−78	−71
1400240	350	368	295	432	401	364	376	381	347	439	383	347
7510379	17	14	36	12	31	34	15	4	6	1	10	3
2640025	−89	−80	−56	−49	−58	−43	−66	−63	−62	−78	−38	−54
3130296	−98	−113	−83	−115	−108	−99	−96	−94	−55	−79	−104	−110
3520601	−160	−166	−163	−149	−177	−173	−168	−165	−153	−224	−176	−182
1110091	271	264	228	263	251	281	259	262	284	255	260	263
3130370	427	415	396	457	395	389	425	431	432	450	444	436
2030332	−173	−171	−165	−189	−178	−165	−178	−173	−186	−178	−177	−178
670209	246	244	261	263	256	256	247	253	252	264	243	253
6560161	−235	−240	−235	−260	−241	−245	−240	−238	−244	−250	−239	−242
1740647	−300	−310	−305	−321	−296	−303	−300	−297	−305	−322	−298	−309
4880463	68	68	86	70	70	83	69	66	79	61	68	69
990315	−32	−37	−47	−43	−16	−71	−36	−34	−47	−61	−29	−32
240463	−72	−69	−65	−61	−63	−63	−56	−67	−32	−22	−43	−49
2000035	−298	−304	−289	−326	−309	−297	−298	−293	−308	−309	−293	−311
1780709	−58	−53	−115	−60	−65	−27	−61	−70	−50	−95	−75	−48
2680440	−184	−187	−191	−203	−184	−183	−188	−189	−186	−198	−185	−186
150672	131	132	148	147	121	126	134	145	135	125	136	141
6940176	−76	−88	7	−89	−36	−74	−89	−84	−68	−121	−81	−104
6180497	121	118	116	123	123	111	122	121	135	116	118	111
150706	−20	−22	17	−8	−33	−45	−23	−26	−29	−22	−19	−24
5900129	−181	−167	−165	−166	−144	−156	−151	−169	−119	−187	−161	−135
6450437	−363	−368	−359	−396	−368	−369	−365	−360	−379	−369	−363	−369
3990608	293	286	317	336	239	291	287	288	280	298	287	292
3120075	−57	−65	8	−67	−61	−74	−67	−68	−68	−84	−60	−66
1500047	−193	−196	−222	−209	−206	−186	−198	−190	−208	−204	−195	−213
840358	−52	−46	−57	−44	−78	−21	−52	−45	−52	−41	−51	−36
6590484	−70	−74	−67	−82	−82	−82	−77	−73	−66	−112	−81	−92
2100594	−84	−103	−61	−117	−112	−98	−101	−114	−124	−126	−112	−114
6650056	166	176	186	187	180	166	174	172	191	166	173	181
2120017	69	67	74	77	87	76	74	78	84	61	79	79
1780639	−65	−64	−52	−64	−70	−60	−62	−63	−67	−66	−62	−65
6650594	−285	−322	−247	−342	−298	−272	−310	−320	−339	−356	−312	−331
3420136	−139	−144	−126	−153	−149	−131	−141	−139	−139	−144	−140	−146
6760017	−138	−123	−130	−136	−162	−124	−134	−119	−136	−163	−128	−108
510209	−66	−60	−126	−63	−44	−70	−56	−66	−80	−14	−67	−61
4220673	−191	−199	−199	−210	−175	−195	−188	−185	−191	−198	−188	−200
Intercept	19978	20602	19656	20443	20673	19330	19853	19517	19384	23046	19209	20247
ProbeID	S14_pre	S15_pre	S16_pre	S17_pre	S18_pre	S20_pre	S21_pre	S22_pre	S23_pre
3390368	−191	−180	−184	−184	−183	−184	−197	−184	−172
1300687	140	127	134	133	131	133	175	134	128
5860465	33	28	29	33	33	33	29	33	21
4390576	−365	−359	−370	−356	−351	−354	−396	−352	−337
4830255	193	177	190	187	182	188	247	187	170
4570403	−429	−392	−415	−418	−405	−416	−481	−418	−412
1780719	95	77	65	64	54	68	129	98	102
3130477	−35	−39	−46	−44	−45	−42	−166	−21	14
6110630	−487	−492	−446	−480	−464	−482	−432	−481	−446
3310309	−352	−346	−347	−342	−336	−340	−408	−337	−322
4220731	182	175	157	164	168	164	236	147	142
520706	33	47	51	49	42	47	57	36	9
6420446	−78	−89	−66	−78	−89	−75	17	−66	−82
1400240	373	367	370	368	366	360	296	361	404
7510379	10	8	7	12	13	10	67	8	6
2640025	−64	−12	−48	−63	−68	−66	−94	−47	−25
3130296	−124	−116	−107	−100	−84	−103	−185	−93	−77
3520601	−165	−202	−176	−176	−165	−169	−231	−180	−194
1110091	252	245	243	261	251	258	172	271	232
3130370	415	411	418	427	408	421	352	396	425
2030332	−186	−185	−182	−180	−168	−181	−200	−175	−170
670209	267	240	250	250	252	252	368	244	232
6560161	−251	−242	−240	−242	−239	−241	−275	−235	−228
1740647	−309	−287	−304	−299	−295	−299	−342	−287	−279
4880463	72	58	64	69	61	68	147	66	75
990315	−25	−39	−32	−34	−43	−29	4	−32	−17
240463	−59	−39	−61	−57	−55	−53	−101	−59	−33
2000035	−309	−297	−313	−300	−297	−300	−349	−287	−293
1780709	−73	−89	−47	−67	−55	−63	−36	−87	−94
2680440	−193	−191	−195	−188	−186	−188	−208	−190	−166
150672	150	142	144	137	134	140	213	115	151
6940176	−81	−80	−92	−86	−97	−90	−141	−109	−143
6180497	120	78	124	122	129	118	93	139	141
150706	−21	1	−18	−22	−29	−20	−31	−20	−14
5900129	−199	−141	−158	−181	−139	−162	−225	−159	−154
6450437	−380	−358	−379	−367	−358	−364	−448	−367	−333
3990608	272	289	310	296	315	290	90	286	249
3120075	−66	−60	−70	−65	−66	−66	−21	−65	−66
1500047	−195	−203	−203	−195	−193	−197	−241	−173	−196
840358	−52	−61	−30	−45	−37	−47	−50	−57	−50
6590484	−84	−91	−70	−79	−93	−80	−218	−80	−92
2100594	−114	−137	−118	−109	−130	−101	−141	−142	−90
6650056	184	171	177	175	176	174	234	179	161
2120017	73	102	78	72	80	76	117	78	65
1780639	−67	−60	−61	−62	−63	−62	−78	−73	−46
6650594	−332	−311	−330	−310	−300	−319	−270	−308	−325
3420136	−146	−145	−147	−142	−139	−140	−185	−134	−140
6760017	−113	−114	−137	−122	−113	−126	−20	−81	−100
510209	−78	−68	−79	−67	−48	−65	−85	−81	−61
4220673	−196	−189	−203	−190	−186	−190	−240	−188	−175
Intercept	20979	20488	20162	19945	19272	19998	24896	19939	18424
ProbeID	S25_pre	S26_pre	L5_pre	L6_pre	L7_pre	L8_pre	L9_pre	L10_pre	L11_pre	L12_pre
3390368	−180	−185	−180	−198	−100	−179	−160	−170	−192	−186
1300687	144	137	128	149	84	109	126	124	139	133
5860465	31	21	32	15	34	19	26	41	28	34
4390576	−359	−374	−362	−374	−211	−318	−314	−308	−362	−360
4830255	162	144	215	209	97	258	187	212	180	185
4570403	−427	−443	−421	−436	−237	−359	−373	−377	−417	−420
1780719	66	98	61	83	−7	163	66	11	37	67
3130477	0	−51	−48	−60	57	−55	−43	−53	−24	−50
6110630	−453	−429	−493	−435	−515	−399	−472	−444	−502	−469
3310309	−356	−362	−341	−372	−193	−292	−285	−297	−355	−344
4220731	202	159	161	230	−48	186	147	180	183	157
520706	79	92	28	43	78	22	69	36	18	55
6420446	−36	−72	−99	−68	−68	−62	−54	−119	−62	−78
1400240	280	323	402	443	157	363	363	399	336	368
7510379	16	0	17	8	−1	−57	15	32	20	15
2640025	−46	−60	−67	−27	−283	37	−62	−124	−10	−70
3130296	−104	−139	−128	−170	95	−187	−92	−83	−108	−100
3520601	−167	−170	−178	−198	−89	−230	−184	−148	−169	−169
1110091	273	254	248	283	242	157	254	241	275	260
3130370	412	493	406	410	477	346	425	373	454	421
2030332	−184	−177	−174	−184	−146	−177	−166	−176	−172	−178
670209	243	261	273	256	109	198	239	213	241	247
6560161	−253	−251	−246	−260	−133	−227	−220	−214	−229	−242
1740647	−314	−325	−312	−325	−157	−273	−255	−266	−301	−303
4880463	75	76	63	83	36	79	67	50	63	70
990315	−54	−18	−66	−14	−32	−4	−3	−44	−37	−31
240463	−75	−78	−77	−52	−59	−30	−75	−73	−68	−56
2000035	−306	−324	−299	−326	−175	−252	−266	−264	−297	−301
1780709	−63	−40	−32	−126	28	−84	−63	−83	−121	−65
2680440	−178	−208	−194	−173	−125	−177	−180	−164	−195	−189
150672	158	152	138	151	66	150	122	143	123	137
6940176	−106	−79	−54	−62	−106	−33	−131	−126	−62	−91
6180497	101	116	139	47	183	18	118	145	92	121
150706	−31	−26	11	−24	−73	51	−13	−77	−5	−23
5900129	−168	−158	−173	−190	47	−266	−164	−123	−187	−188
6450437	−376	−399	−373	−404	−231	−313	−333	−314	−362	−367
3990608	360	292	275	286	214	334	316	334	263	295
3120075	−42	−74	−61	−52	−73	−87	−62	−82	−55	−65
1500047	−189	−177	−196	−195	−39	−222	−153	−194	−194	−194
840358	−40	−30	−70	−52	19	−144	−20	−34	−51	−48
6590484	−65	−63	−98	−88	−96	5	−100	−39	−33	−79
2100594	−95	−152	−126	−133	−12	−178	−97	−64	−68	−106
6650056	176	183	171	210	95	142	155	165	173	176
2120017	74	76	64	70	102	1	74	20	97	78
1780639	−55	−65	−65	−67	−30	−66	−50	−54	−62	−63
6650594	−300	−345	−336	−376	−227	−257	−292	−259	−277	−309
3420136	−136	−139	−148	−172	−90	−99	−134	−126	−141	−141
6760017	−115	−73	−138	−128	−92	−118	−129	−107	−146	−117
510209	−84	−99	−86	−27	−121	49	−63	−37	−24	−61
4220673	−180	−202	−194	−213	−97	−165	−171	−169	−201	−192
Intercept	19115	20488	21351	20804	13062	17736	17185	17648	19780	19946
	ProbeID	L13_pre	L14_pre	L15_pre	L16_pre	L17_pre	L18_pre	L20_pre	L21_pre	L19_pre
	3390368	−187	−182	−185	−183	−179	−185	−193	−191	−195
	1300687	130	121	133	138	136	135	135	153	125
	5860465	40	47	34	41	39	40	44	33	21
	4390576	−378	−376	−355	−356	−335	−359	−349	−375	−385
	4830255	154	231	185	163	203	189	201	202	161
	4570403	−419	−425	−419	−422	−401	−419	−426	−428	−435
	1780719	85	54	62	43	63	68	79	82	83
	3130477	−57	−39	−37	−50	−11	−42	−55	−44	−14
	6110630	−441	−463	−482	−458	−469	−483	−447	−450	−519
	3310309	−362	−353	−342	−348	−334	−341	−341	−356	−348
	4220731	146	170	160	157	161	160	158	174	206
	520706	74	41	52	28	43	51	32	56	59
	6420446	−89	−47	−78	−75	−83	−82	−100	−96	−86
	1400240	368	332	366	369	383	375	385	367	381
	7510379	31	17	14	20	21	9	11	20	−6
	2640025	−109	25	−58	−51	−55	−70	−25	−54	−69
	3130296	−102	−102	−100	−85	−97	−111	−99	−134	−112
	3520601	−153	−165	−176	−170	−148	−170	−177	−133	−159
	1110091	299	273	260	264	254	254	271	268	331
	3130370	398	377	425	430	433	426	441	411	406
	2030332	−175	−184	−180	−170	−181	−183	−180	−178	−189
	670209	271	272	249	252	253	237	261	255	255
	6560161	−260	−242	−241	−241	−235	−243	−239	−253	−250
	1740647	−308	−324	−302	−302	−295	−307	−311	−314	−311
	4880463	61	71	70	84	57	72	75	84	57
	990315	−26	−31	−31	−24	−28	−40	−45	−8	−13
	240463	−45	−28	−59	−46	−58	−52	−58	−53	−97
	2000035	−308	−302	−302	−301	−295	−302	−306	−316	−291
	1780709	−27	−77	−65	−79	−85	−73	−10	−55	−68
	2680440	−201	−191	−189	−184	−182	−193	−188	−195	−193
	150672	135	107	137	140	144	151	150	168	102
	6940176	−94	−80	−85	−96	−71	−77	−63	−54	−74
	6180497	119	145	121	138	138	77	170	134	115
	150706	−4	−45	−25	−27	−16	−32	−32	−11	−24
	5900129	−153	−186	−159	−126	−148	−184	−153	−170	−195
	6450437	−367	−376	−368	−360	−336	−363	−381	−388	−390
	3990608	283	336	290	280	284	285	284	320	312
	3120075	−52	−54	−65	−67	−66	−62	−76	−59	−80
	1500047	−217	−238	−198	−199	−195	−203	−203	−204	−193
	840358	−22	−74	−44	−39	−57	−37	−53	−65	−30
	6590484	−136	−38	−82	−75	−53	−67	−100	−42	−104
	2100594	−120	−76	−109	−119	−113	−114	−121	−103	−124
	6650056	170	170	174	174	177	185	180	179	164
	2120017	85	77	74	84	66	77	54	92	63
	1780639	−65	−66	−63	−62	−64	−64	−70	−63	−68
	6650594	−307	−266	−309	−291	−302	−320	−317	−321	−327
	3420136	−148	−129	−142	−142	−139	−143	−151	−155	−139
	6760017	−118	−123	−122	−120	−125	−111	−112	−134	−98
	510209	−92	−46	−68	−46	−48	−46	−106	−80	−81
	4220673	−194	−184	−190	−187	−175	−193	−204	−197	−195
	Intercept	20285	18703	20057	19357	17800	20390	19420	18749	21296

TABLE 7
Table 7: Thirty gene sets by random selection.
	Gene	Gene	Gene	Gene	Gene	Gene	Gene	Gene	Gene	Gene	Gene	Gene	Gene	Gene	Gene	Gene
Gene set	ID1	ID2	ID3	ID4	ID5	ID6	ID7	ID8	ID9	ID10	ID11	ID12	ID13	ID14	ID15	ID16
1	97	281	276	300	4	239	55	148	240	140	218	53	126	210	205	31
2	243	211	99	113	49	291	205	259	276	127	48	218	112	18
3	144	4	78	103	157	115	245	278	7	274	225	151	291	273	54	83
4	103	255	188	275	109	11	78	74	257	167	296	119	278	126	138	64
5	96	93	211	85	76	184	216	153	252	54	87	13	209	11	210	83
6	8	298	185	253	254	135	62	69	291	178	256	26	188	272	275	165
7	59	84	261	273	155	251	175	49	86	112	205	198	266	81	162	71
8	67	4	80	14	297	86	271	171	12	135	226	239	3	69	264	46
9	47	163	141	113	205	233	137	150	94	97	276	100	182	79	293	267
10	206	119	201	93	239	222	19	237	14	245	41	184	209	210	85	231
11	233	227	106	19	171	282	118	295	146	266	122	174	108	254	175	123
12	266	257	245	197	165	182	137	21	88	228	167	231	206	242	123	155
13	108	69	194	63	10	35	101	242	186	61	278	107	106	11	168	246
14	244	98	67	260	278	287	144	65	201	108	58	247
15	103	58	257	83	106	159	280	284	132	63	123	264	206	24	72	208
16	24	189	154	33	64	273	62	9	178	199	149	278	34	88	272	299
17	178	179	248	66	37	218	103	167	183	264	242	41	300	100	47	245
18	46	83	102	235	169	141	41	264	151	175
19	191	130	89	77	196	247	134	7	259	232	64	56	224	128	11	273
20	77	169	248	257	225	158	253	281	282	80	128	299	254	148	260	291
21	40	207	229	67	268	63	298	254	102	79	82	112	211	290	89	133
22	67	161	110	236	90	283	164	10	45	134	36	132	52	23	9	203
23	21	84	260	224	111	249	172	92	203	209	274
24	11	265	268	4	191	154	274	292	199	142	224	139	185	239	257	113
25	162	296	183	85	33	41	286	93	251	224	48	221	40	7	73	184
26	222	101	161	185	145	6	135	120	157	291	295	235	53	102	160	155
27	238	30	279	275	135	97	200	44	232	237	35	173	207	27	234	202
28	87	40	175	138	72	43	300	65	187	90	80	50	282	263	124	297
29	48	117	157	57	244	13	289	276	218	49	251	283	140	181	145	267
30	49	168	121	271	47	232	238	95	233	254	71	297	246	27	160	150
		Gene	Gene	Gene	Gene	Gene	Gene	Gene	Gene	Gene	Gene	Gene	Gene	Gene	Gene
	Gene set	ID17	ID18	ID19	ID20	ID21	ID22	ID23	ID24	ID25	ID26	ID27	ID28	ID29	ID30
	1	221	138	132	3	30	182	201	166	142	107	212	264	182
	2
	3	91
	4	116	36
	5	109	253	107
	6	182	289	167	20	6	204
	7	126	246	44	128	156	22	85	177	80	74
	8	184	160	84	186	45	285	230	203	278	25	292
	9	247	70	1	272	203	38	84	180	39	211	82	178
	10	177	208	150	175	23
	11	128	66	79
	12	293	290	102	258	240	16	162	144	221	38
	13	277	68	78	139	218
	14
	15	93	65	52	203	17	81	117	142	299	47	131	288	98	177
	16	168	206	203	263
	17	9	175	57	287	106	196	150
	18
	19	276	69	243	291	155	254	266	63	92	219	136	185	299	132
	20	298	74	5
	21
	22	230	299	202	28	255	125	296	103	62	47	72	178	162	238
	23
	24	267	120	150	247	27	201	91	112	178	18	125
	25	67	174	298	173	234	269	102	3	43
	26	273	83	297	298	191	243	249	70	27	230
	27	298	158	194	136	118	28	268	210	299	188	262
	28	213	294	242	104	201	214
	29	287	248
	30	262	129	98	251	89	237	294	156
	* The numbers represent the ranks in Table 1.

Claims

1. A method for predicting effect of immunotherapy on a cancer patient and/or prognosis of the cancer patient after the immunotherapy, which comprises the steps of: (1) determining expression level of each gene in a gene set which consists of at least 1 gene selected from the group of genes shown in any of Tables 1-5 and(2) performing statistical processing of the expression level to calculate predicted survival time.

2. The method of claim 1, wherein the statistical processing is performed by regression analysis.

3. The method of claim 1, wherein the immunotherapy is peptide vaccine therapy.

4. The method of claim 1, wherein the cancer is prostate cancer.

5. A gene set for predicting effect of immunotherapy on a cancer patient and/or prognosis of the cancer patient after the immunotherapy, which consists of at least 1 gene selected from the group of genes shown in any of Tables 1-5.

6. The gene set of claim 5, wherein said at least 1 gene is selected in descending order from the top of the group of genes shown in any of Tables 1-5.

7. The gene set of claim 5, which consists of at least 10 genes.

8. The gene set of claim 5, wherein the immunotherapy is peptide vaccine therapy.

9. The gene set of claim 5, wherein the cancer is prostate cancer.

10. A kit for predicting effect of immunotherapy on a cancer patient and/or prognosis of the cancer patient after the immunotherapy, which comprises a probe or primer for each gene in the gene set of claim 5.

11. The kit of claim 10, which is used for DNA microarray analysis.

12. The kit of claim 10, wherein the cancer is prostate cancer.