Patent Grant
11872573
The invention relates to manufacture of aperture plates (or “vibrating membranes”) for aerosol (or “nebulizer”) devices.
An aperture plate is used for aerosol delivery of liquid formulations in a controlled liquid droplet size suitable for pulmonary drug delivery. The ideal nebulizer is one which assures a consistent and accurate particle size in combination with an output rate that can be varied to deliver the drug to the targeted area as efficiently as possible. Delivery of the aerosol to the deep lung such as the bronchi and bronchiole regions requires a small and repeatable particle size typically in the range of 2-4 μm. In general, outputs greater than 1 ml/min are required.
U.S. Pat. Nos. 6,235,177, 7,066,398 and 8,398,001 describe an approach to manufacturing an aperture plate in which a wafer is built onto a mandrel by a process of electro-deposition where the dissolved metal cations in the plating bath (typically Palladium and Nickel) are reduced using electrical current from the liquid form to the solid form on the wafer. Material is reduced only to the conducting surface on the mandrel and not to photo resist islands which are non-conducting. The aperture hole size and profile are defined by the three dimensional growth of plated materials, thus, electroforming. After the conclusion of the plating process, the mandrel/wafer assembly is removed from the bath and the wafer peeled from the mandrel for subsequent processing into an aperture plate.
However, a problem with this approach is that the wafer thickness is intertwined with the placement density of the non-conducting resist islands, i.e. the thicker the wafer, the further the distance between the non-conduction resist islands, and the smaller the aperture density. As a result, it is not possible to increase the aperture density to about 90,000 holes per square inch (approx. 650 mm2). Reduced wafer thickness is used to alleviate this issue. If a wafer has a thickness in the range of 50 to 54 μm non-standard drives are required. Also, a reduction in the aperture plate thickness alters the harmonics and natural frequency of the core assembly. To drive this optimally to generate an acceptable flow rate output, it is necessary to alter the drive frequency. This is disadvantageous as it requires the development, manufacture, and supply of a matching drive controller which has consequential cost and lead time implications.
Photo-defined technology as described in WO2012/092163A and WO2013/186031A allows a large number of holes to be produced per unit area because it applies standard wafer processing technology to define the aperture plate hole size and profile through photolithography, thus, “photo-defined”.
This technology may involve plating multiple layers to achieve desired aperture plate geometry and profile, for example, a first layer normally called the outlet or droplet size defining layer, and subsequently imparting a second layer on top of this which is normally called the inlet or reservoir layer. It can be challenging to achieve the correct levels of interfacial adhesion between both layers. And the process is more complex than that for electroforming.
US2006/0203036 describes an approach to fabricating an orifice plate in which there is plating on rings, so that plated material within the rings forms apertures which narrow to a minimum at about half their depth.
The invention is directed towards providing an improved method to address the above problems.
According to the invention, there is provided a method of manufacturing an aperture plate wafer, the method comprising providing a substrate of conductive material, applying a mask over the substrate in a pattern of columns having top surfaces, electroplating (3) around the columns, removing the mask to provide a wafer of the electroplated material with aerosol-forming holes,
In one embodiment, the columns have a height in the range of 55 μm to 65 μm.
In one embodiment, the column width dimension is in the range of 20 μm to 40 μm.
In one embodiment, the column width dimension is in the range of 25 μm to 35 μm.
In one embodiment, the combined aperture plate wafer thickness achieved by the column height and the height of over-plating is in the range of 50 μm to 70 μm.
In one embodiment, the aperture size is in the range of 2 μm to 6 μm.
In one embodiment, the over-plating is controlled and the column dimensions are chosen to also achieve a desired slope of wafer material towards the aerosol-forming apertures to achieve a funnelling effect for liquid in use.
In one embodiment, the wafer is formed into a dome shape which is concave on the side of the apertures, and the extent of curvature and the shape of the over-plated metal is chosen to provide a funnelling effect for liquid towards the apertures.
In one embodiment, the top surfaces of at least some columns are generally convex.
In one embodiment, the columns are configured so that when the masking material is removed they form passageways aligned with the apertures and being shaped for entrainment of droplets form the apertures.
In one embodiment, at least some of the columns have a configuration widening towards the substrate so that after removal of the masking material they form passageways which widen in a direction away from the apertures.
In one embodiment, the passageways are gradually tapered with a consistent slope.
Preferably, the passageways have a length in the range of range of 40 μm to 70 μm.
In another aspect, the invention provides an aperture plate comprising a body of metal configured with aerosol-forming apertures in a top surface and passageways aligned with and beneath the apertures, wherein the metal forms convex shapes around the apertures to provide a funnel-shaped entrance to the apertures.
Preferably, said passageways have a length in the range of 40 μm to 70 μm. In one embodiment, the passageways widen towards the lower side of the plate.
In one embodiment, the passageways have a length of 55 μm to 65 μm, and the aperture plate has a thickness in the range of 50 μm to 70 μm; and wherein the passageways have a width in the range of 20 μm to 40 μm. In one embodiment, the passageways have a width in the range of 25 μm to 35 μm.
In another aspect, the invention provides an aerosol-forming device comprising an aperture plate as defined above in any embodiment, a support for the aperture plate, and a drive for the aperture plate.
According to the invention, there is provided a method of manufacturing an aperture plate wafer, the method comprising providing a substrate of conductive material, applying a mask over the substrate in a pattern of columns, electroplating the spaces around the columns, removing the mask to provide a wafer of the electroplated material with aerosol-forming holes where the mask columns were, wherein the electroplating step partially over-plates the tops of the columns while leaving aerosol-forming apertures of a desired size.
In one embodiment, the column height is chosen to achieve a desired wafer thickness.
In one embodiment, the columns have a height in the range of 40 μm to 70 μm, and preferably 55 μm to 65 μm. In one embodiment, the column width dimension is in the range of 20 μm to 40 μm, preferably 25 μm to 35 μm.
In one embodiment, the combined wafer plate achieved by the column height and the height of over-plating is in the range of 50 μm to 70 μm. Preferably, the aperture size is in the range of 2 μm to 6 μm.
In one embodiment, the over-plating is controlled and the column dimensions are chosen to also achieve a desired slope of wafer material towards the aerosol-forming apertures to achieve a funnelling effect for liquid. In one embodiment, the wafer is formed into a dome shape which is concave on the side of the apertures, and the extent of curvature and the shape of the over-plated metal is chosen to provide a funnelling effect for liquid towards the apertures.
In one embodiment, at least some columns have a generally convex top surface.
In one embodiment, the columns are configured so that when the masking material is removed they form passageways aligned with the apertures and being shaped for entrainment of droplets form the apertures.
In one embodiment, at least some of the columns have a configuration widening towards the substrate so that after removal of the masking material they form passageways which widen in a direction away from the apertures. Preferably, the passageways are gradually tapered with a consistent slope. In one embodiment, the plated metal includes Ni. In one embodiment, the plated metal includes Pd. In one embodiment, both Ni and Pd are present in the plated metal.
In one embodiment, both Ni and Pd are present in the plated metal; and wherein the proportion of Pd is in the range of 85% w/w and 93% w/w, and preferably about 89%, substantially the balance being Ni.
In one embodiment, the method comprises the further steps of further processing the wafer to provide an aperture plate ready to fit into an aerosol-forming device. In one embodiment, the wafer is punched and formed into a non-planar shaped aperture plate. In one embodiment, the wafer is annealed before punching.
In another aspect, the invention provides an aperture plate wafer comprising a body of metal whenever formed in a method as defined above in any embodiment.
In another aspect, the invention provides an aperture plate comprising a body of metal configured with aerosol-forming apertures in a top surface and passageways aligned with and beneath the apertures.
In one embodiment, the metal body forms convex shapes around the apertures to provide a funnel-shaped entrance to the apertures. In one embodiment, the passageways widen towards the lower side of the plate.
In one embodiment, the passageways are gradually tapered with a uniform sloped taper.
In one embodiment, the passageways have a length of 40 μm to 70 μm, and preferably 55 μm to 65 μm, and the aperture plate has a thickness in the range of 50 μm to 70 μm.
In one embodiment, the passageways have a width in the range of 20 μm to 40 μm, preferably 25 μm to 35 μm.
An aerosol-forming device comprising an aperture plate as defined above in any embodiment.
The invention will be more clearly understood from the following description of some embodiments thereof, given by way of example only with reference to the accompanying drawings in which:
Referring to
An aperture plate is manufactured by plating metal around a mask of resist columns 2 having a height of about 45 μm, a diameter of about 30 μm and a separation of about 30 μm. The plating is continued so that the metal 3 overlies the top surfaces of the columns until the desired apertures 4 are achieved. This provides the benefits of both photo-defined technology (by reducing the aspect ratio near the aperture region during electroforming) and aperture density by enabling more closely patterned resist islands, with need for only one masking/plating cycle to achieve the desired plate thickness.
In more detail, non-conductive photo-resist 2 is laid on to a mandrel 1 substrate. This is developed to leave the upstanding columns 2 where holes are required. The tops of the columns 2 are approximately convex. The mandrel is placed in an electroforming tank. As the plating continues, the space between the columns 2 of developed photo resist is in-filled with the plating material. This is typically a PdNi alloy matrix, or it could alternatively be Nickel or a Nickel Cobalt alloy matrix.
The plating is initially to the extent shown in
The diametrical size accuracy of these holes can be improved by slowing down the plating deposition activity as the holes are being formed. This prevents ‘overshoot’ resulting in smaller or occluded holes with the possibility of a thicker than desired wafer construction. The 45 μm column height is so chosen such that when the plating is stopped (
The convex shape of the entry surfaces to the apertures in addition to the concave shape of the overall domed shaped aperture plate (
In an alternative embodiment (
As evident from
These much larger holes 34 in comparison (to the aperture diameter) can entrain the aerosol, almost into a laminar flow pattern. This reduces turbulence and consequential coalescence which can lead to an undesirable increase in droplet size. These openings may be tapered (
The resultant wafer 10 has a greater number of holes, greater than 44,100 per 650 mm2 (square inch, Mesh 210), than the prior art and yet maintains the same aperture plate thickness (approximately 61 μm) as many commercially available products. This ensures that the existing drive controllers (128 kHz) already in situ in many hospitals can be used for the aperture plate, alleviating the cost and considerable time required to be expended to develop a bespoke drive controller to ensure that the correct frequency is available to achieve optimum aerosol output. It is also more conducive for meeting and exceeding the fatigue life requirements. As there is single-layer plating it incorporates a fine equiaxed microstructure.
It will be appreciated that the method provides the benefits of both photo-defined technology, partially decoupling the dependence of wafer thickness to resist island patterning distance and increased aperture density, with the process simplicity of electroforming, because it needs only one masking/plating cycle to achieve the desired plate thickness.
Those skilled in the electro-deposition field will appreciate how the plating conditions may be chosen to suit the circumstances, and the entire contents of the following documents are herein incorporated by reference: U.S. Pat. Nos. 4,628,165, 6,235,117, US2007023547, US2001013554, WO2009/042187, and Lu S. Y., Li J. F., Zhou Y. H., “Grain refinement in the solidification of undercooled Ni—Pd alloys”, Journal of Crystal Growth 309 (2007) 103-111, Sep. 14, 2007. Generally, most electroplating solutions involving Palladium and Nickel would work or Nickel only or indeed Phosphorous & Nickel (14:86) or Platinum. It is possible that a non-Palladium wafer could be plated at the surface (1-3 microns thick) in PdNi to impart more corrosion resistance. This would also reduce the hole sizes if smaller openings were desired.
The resist geometry, such as height, width, and shape, is configured in such a way as to increase the number of holes while maintaining the desired wafer thickness. Further increase of hole density is also possible. For example, the invention in one embodiment achieves an aperture plate of about 4 times the density (moving from 210 to 420 holes per 25 mm (linear inch) or from 44,100 to 176,400 holes per 650 mm2 (square inch), while still maintaining the typical 60 to 62 μm thickness range.
Adjusting the dimensions in
The invention avoids need for two-layer photo defined technology to increase the number of holes while maintaining the same wafer thickness. It also solves the problem of using standard plating defined technology as referred to in the Prior Art Discussion with a greater number of holes which will result in a lower thickness wafer, thus requiring significant changes to the core construction, or more typically the drive controller, to find the optimum drive frequency.
The invention finds particular application where faster nebulisation treatment times are required. This is usually required for hand-held devices when aerosol is administrated through the mouth or nasal passages in fully mobile patients. These are typically patients who administer nebulised drugs in a non-hospital setting.
This is in contrast to intubated hospital patients who are typically on mechanical ventilation where treatment times are less important as long as the patient gets the full prescribed dose.
Techniques for vibrating the aperture plates are described generally in U.S. Pat. Nos. 5,164,740; 5,586,550; and 5,758,637, which are incorporated herein by reference. The aperture plates are constructed to permit the production of relatively small liquid droplets at a relatively fast rate. For example, the aperture plates of the invention may be employed to produce liquid droplets having a size in the range from about 2 μm to about 10 μm, and more typically between about 2 μm to about 5 μm. In some cases, the aperture plates may be employed to produce a spray that is useful in pulmonary drug delivery procedures. As such, the sprays produced by the aperture plates may have a respirable fraction that is greater than about 70%, preferably more than about 80%, and most preferably more than about 90% as described in U.S. Pat. No. 5,758,637.
In some embodiments, such fine liquid droplets may be produced at a rate in the range from about 2 μl (microliters) per second to about 25 μl per second per 1000 apertures. In this way, aperture plates may be constructed to have multiple apertures that are sufficient to produce aerosolized volumes that are in the range from about 2 μl to about 25 within a time that is less than about one second. Such a rate of production is particularly useful for pulmonary drug delivery applications where a desired dosage is aerosolized at a rate sufficient to permit the aerosolised medicament to be directly inhaled. In this way, a capture chamber is not needed to capture the liquid droplets until the specified dosage has been produced. In this manner, the aperture plates may be included within aerosolisers, nebulizers, or inhalers that do not utilise elaborate capture chambers.
The aperture plate may be employed to deliver a wide variety of drugs to the respiratory system. For example, the aperture plate may be utilized to deliver drugs having potent therapeutic agents, such as hormones, peptides, and other drugs requiring precise dosing including drugs for local treatment of the respiratory system. Examples of liquid drugs that may be aerosolized include drugs in solution form, e.g., aqueous solutions, ethanol solutions, aqueous/ethanol mixture solutions, and the like, in colloidal suspension form, and the like. The invention may also find use in aerosolizing a variety of other types of liquids, such as insulin.
It will be appreciated that the invention allows the production of a wafer from which nebuliser aperture plates are punched in one single plating step and facilitates the creation of a larger number of holes than that known today (typically up to 400%). Also, it facilitates the use of aperture plates which are 60 to 62 μm thick. Also, it allows an increase in the number of holes per unit of area while still being able to control the plating thickness to a predetermined dimension.
The above in combination allows the creation of a higher output nebuliser while still maintaining the standard drive controller and core construction all of which is accomplished in a very economical manner.
This application is a continuation of U.S. application Ser. No. 16/358,338 filed Mar. 19, 2019, which is a continuation of U.S. application Ser. No. 14/719,036, filed May 21, 2015, which claims priority to U.S. Provisional Application No. 62/002,435, filed May 23, 2014, the contents of all of which are herein incorporated by reference in their entireties.
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| Number | Date | Country | |
|---|---|---|---|
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| Child | 17818484 | US | |
| Parent | 14719036 | May 2015 | US |
| Child | 16358338 | US |
