Claims
- 1. A method for production of the compound represented by Formula (1): ##STR10## wherein R.sup.1 and R.sup.2 represent, respectively, a hydrogen atom, an alkyl group having 1 to 5 carbon atoms or an aromatic group, or they may form a ring, which may contain a nitrogen atom, an oxygen atom or a sulfur atom together with N group; R.sup.4 represents a hydrogen atom, an alkyl group having 1 to 5 carbon atoms or an aromatic group; R.sup.3 represents a single bond or an alkylene group having 1 to 5 carbon atoms; and X represents a chlorine atom, a bromine atom, an iodine atom or a fluorine atom, comprising reacting guanine with a compound represented by Formula (3): ##STR11## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as defined as above, in the presence of a halogenating agent.
- 2. The method according to claim 1, wherein said halogenating agent is used in an amount of 2 to 10 mol per mol of said guanine.
- 3. The method according to claim 1, wherein said compound represented by Formula (3) is used in an amount of 1 to 20 mol when a solvent is used, and 5 to 30 mol when a solvent is not used, per mol of said guanine.
- 4. The method according to claim 1, wherein said compounds represented by Formula (3) is selected from the group consisting of N,N-dimethylformamide, N,N-diethylformamide, N-methylformanilide, N,N-dimethylacetamide, N-formylpyrrolidine, N-formylpiperidine, N-formylpiperazine, N-formylmorpholine and N-formylthiomorpholine.
- 5. The method according to claim 1, wherein said halogenating agent is selected from the group consisting of phosphorus oxychloride, thionyl chloride, sulfuryl chloride, phosphorus trichloride, phosphorus pentachloride, phosgene, diphosgene, phosphorus oxybromide, thionyl bromide, phosphorus tribromide, phosphorus pentabromide, phosphorus triiodide, phosphorus trifluoride and phosphorus oxyfluoride.
Priority Claims (1)
Number |
Date |
Country |
Kind |
3-334053 |
Nov 1991 |
JPX |
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Parent Case Info
This application is a divisional copending application Ser. No. 08/115,015, filed on Sep. 2, 1993, now U.S. Pat. No. 5,389,631, which is a divisional of application Ser. No. 07/937,427, filed on Aug. 31, 1992, now U.S. Pat. No. 5,391,733, the entire contents of which are hereby incorporated by reference.
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Divisions (2)
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Number |
Date |
Country |
Parent |
115015 |
Sep 1993 |
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Parent |
937427 |
Aug 1992 |
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