Method for quality control of an attenuated vericella live vaccine

Abstract

Disclosed is a method for quality control of an attenuated varicella live vaccine, which comprises subjecting the genomic DNA of a sample varicella vaccine virus to sequence analysis and confirming that the genomic DNA of the sample varicella vaccine virus conserves the 5,745th G, the 105,356th C, the 105,544th G, the 106,262nd C and the 107,252nd C without suffering mutation, wherein the nucleotide numbers are in accordance with the nucleotide numbering system of the nucleotide sequence of the genomic DNA of the varicella virus Dumas strain of SEQ ID NO: 1.

Description

BACKGROUND OF THE INVENTION

1. Field of the Invention

The present invention relates to a method for quality control of an attenuated varicella live vaccine. More particularly, the present invention relates to a method for quality control of an attenuated varicella live vaccine, which comprises subjecting the genomic DNA of a sample varicella vaccine virus to sequence analysis and confirming that the genomic DNA of the sample varicella vaccine virus conserves the specific nucleotides without suffering mutation. By the use of the method of the present invention, it has become possible to determine very accurately the qualification of an attenuated varicella virus as an active ingredient of an attenuated varicella live vaccine and, consequently, to conduct an exact quality control of the vaccines.

2. Prior Art

As is well known, attenuated varicella live vaccines used today are produced from a seed strain of varicella virus which is derived from the attenuated varicella virus Oka strain (see Examined Japanese Patent Application Publication No. 53-41202 and U.S. Pat. No. 3,985,615), and the attenuated live vaccines are used widely throughout the world (Requirements for Varicella Vaccine (Live) Adopted 1984; Revised 1993: WHO Technical Report Series, No. 848, pp. 22-38, 1994). To ensure the safety and effectiveness of the vaccine, the number of passages of a virus used for producing the vaccine is restricted under the control of a seed lot system, taking into consideration the potential genetic mutation which is likely to occur during the passage. That is, the manufacturers are under an obligation to produce varicella vaccines only from the virus derived from the approved seed virus for the live varicella vaccine, wherein the number of passages of the virus is not more than 10 as counted from the approved seed virus which is counted as 0 passage. In other words, the quality control and quality assurance of the attenuated varicella live vaccine rely upon the fulfillment of the seed lot system by the manufacturers, and such a method for the quality control and quality assurance is not a method which can be traced and analyzed by a person skilled in the art.

Further, from the viewpoint of epidemiology which involves a tracing of the effects of the varicella vaccine and a post-market surveillance (PMS), the virological difference between the fresh wild-type strains isolated from the naturally infected varicella patients and the vaccine virus strains derived from the above-mentioned Oka strain needs to be determined, and various analyses, such as those utilizing immunological techniques and genetic engineering techniques, have been attempted for determination of the virological difference. For example, the following analyses have been reported: the difference in DNA sequence between the various VZV strains (Journal of virology, 59, 660-668, 1986; Journal of General virology, 67, 1759-1816, 1986), the difference in the absence or presence of a restriction enzyme Pst I cleavage site (Japanese Journal of Experimental Medicine, 59, 233-237, 1989), the difference in RFLP (restriction fragment length polymorphism) of the PCR (polymerase chain reaction) product (Journal of virology, 66, 1016-1020, 1992), and the difference in the absence or presence of a restriction enzyme Pst I restriction site which is taken in combination with the difference in RFLP of the PCR product (Journal of Clinical Microbiology, 33, 658-660, 1995). However, all of these analyses only propose criteria which can be used for differentiating a fresh wild-type strain from a vaccine strain derived from the Oka strain, and such analyses lack reliability and exactness. In addition, a method for identifying the attenuated varicella virus Oka strain by using gene 14 region (U.S. Pat. No. 6,093,535) and a method for identifying the attenuated varicella live vaccine virus by using gene 62 region (International Patent Application Publication No. WO 00/50603) have been known. Both of these methods enabled a determination of the differences among the varicella virus Oka strain (virulent parental strain), a vaccine strain derived therefrom (attenuated Oka strain) and a varicella virus strain other than the Oka strain, but neither of these methods was satisfactory as a standard for the quality control and quality assurance of the attenuated varicella live vaccine.

As mentioned above, at present, the quality of the attenuated varicella virus used as an active ingredient of an attenuated varicella live vaccine is controlled by the fulfillment of the seed lot system by the manufacturers. In other words, a method which can be traced and analyzed by a third party for evaluating and confirming the effectiveness of the vaccine, such as a method utilizing a direct and quantitative genetic analysis of the genomic DNA of a seed virus or a vaccine virus, has not been used for the quality control of the vaccine and, thus, the exactness of the quality control is incomputable and vague. Therefore, an improvement in the exactness of the quality control and quality assurance is critically important for assuring the effectiveness, safety and uniformity of the attenuated varicella live vaccine. However, as mentioned above, a reliable method for the quality control has not been established, and a development of such a method has been earnestly desired in the art.

SUMMARY OF THE INVENTION

In the above situation, the present inventors have made extensive and intensive studies with a view toward developing a novel method for accurately and quantitatively conducting the quality control of an attenuated varicella live vaccine. Specifically, the present inventors determined the whole genomic nucleotide sequence of the attenuated varicella virus Oka strain containing more than 120,000 nucleotides, conducted a comparative analysis between the determined nucleotide sequence of the attenuated Oka strain and the whole genomic nucleotide sequences of the virulent strain and the parental Oka strain (virulent strain), and identified the genetic mutations of the attenuated varicella virus Oka strain. As a result, they have found that, by evaluating and determining whether or not a varicella virus strain conserves the below-mentioned specific nucleotides, a virus strain conserving the specific nucleotides can be determined accurately as a virus strain capable of functioning as an attenuated varicella vaccine virus. The present invention has been completed, based on this novel finding.

Therefore, it is an object of the present invention to provide a novel method for the quality control of an attenuated varicella live vaccine.

It is another object of the present invention to provide an attenuated varicella live vaccine which is quality-controlled by the above-mentioned method.

It is a further object of the present invention to provide a vaccine strain capable of functioning as an attenuated varicella vaccine virus, which is identified by a method used in the above-mentioned method.

The foregoing and other objects, features and advantages of the present invention will be apparent to those skilled in the art from the following detailed description and the appended claims taken in connection with the accompanying sequence listing and drawings.

SEQUENCE LISTING FREE TEXT

SEQ ID NOs: 3 and 4 are of PCR primers used for detecting a mutation of the 560th nucleotide of a varicella vaccine virus.

SEQ ID NOs: 5 and 6 are of PCR primers used for detecting a mutation of the 5,745th nucleotide of a varicella vaccine virus.

SEQ ID NOs: 7 and 8 are of PCR primers used for detecting a mutation of the 26,125th nucleotide of a varicella vaccine virus.

SEQ ID NOs: 9 and 10 are of PCR primers used for detecting a mutation of the 94,167th nucleotide of a varicella vaccine virus.

SEQ ID NOs: 11 and 12 are of PCR primers used for detecting mutations of the 105,356th, 105,544th, 124,353rd and 124,541st nucleotides of a varicella vaccine virus.

SEQ ID NOs: 13 and 14 are of PCR primers used for detecting mutations of the 105,705th, 106,262nd, 123,635th and 124,192nd nucleotides of a varicella vaccine virus.

SEQ ID NOs: 15 and 16 are of PCR primers used for detecting mutations of the 107,136th, 107,252nd, 122,645th and 122,761st nucleotides of a varicella vaccine virus.

SEQ ID NOs: 17 and 18 are of PCR primers used for detecting mutations of the 108,111st and 121,786th nucleotides of a varicella vaccine virus.

BRIEF DESCRIPTION OF THE DRAWINGS

In the drawings:

FIG. 1 is a genetic map of the varicella virus Oka strain showing the number and direction of each gene, wherein, ∇ represents a synonymous substitution, ▾ represents a nonsynonymous substitution, ∇ represents a mutation in a noncoding region, ◯ represents deletion or insertion, the genome length is shown every 20 kb, R1 to R4 represent repetitive sequences, Ori represents an origin of replication, TRL represents a “Terminal Repeat Long”, UL represents a “Unique Long”, IRL represents an “Internal Repeat Long”, IRS represents an “Internal Repeat Short”, US represents a “Unique Short”, and TRS represents a “Terminal Repeat Short”; and wherein the nucleotide sequence of gene 62 to gene 64 and the nucleotide sequence of gene 69 to gene 71 are symmetrical to each other (i.e., the two nucleotide sequences are inverted repeats); and

FIG. 2 shows the electropherograms which are the results of the RFLP analyses conducted in Example 4, wherein, the restriction enzymes used for treating the PCR products are as follows: FIG. 2 ( a ) was obtained using Nla III, FIG. 2 ( b ) was obtained using Alu I, FIG. 2 ( c ) was obtained using Bst X I, FIG. 2 ( d ) was obtained using Sfa N I, FIG. 2 ( e ) was obtained using Acc II, FIG. 2 ( f ) was obtained using Sac II, FIG. 2 ( g ) was obtained using Sma I, FIG. 2 ( h ) was obtained using Bss H II and Nae I in combination, and FIG. 2 ( i ) was obtained using Bsr I; and wherein, V represents the attenuated Oka strain, P represents the parental Oka strain, and K represents the Kawaguchi strain.

The terminologies used in the present specification are defined in the following items (a) to (g).

(a) VZV: A virus which causes varicella and herpes zoster. “VZV” is an abbreviation for “varicella-zoster virus” which is frequently referred to simply as “varicella virus”.

(b) Varicella vaccine virus and varicella vaccine: A varicella vaccine virus is an active ingredient of a vaccine and it is an attenuated virus. A varicella vaccine is a vaccine effective for preventing the infection with a VZV or the onset of the disease after the infection.

(c) Attenuated Oka strain: Attenuated Oka strain is the attenuated varicella virus Oka strain (see Examined Japanese Patent Application Publication 53-41202 and U.S. Pat. No. 3,985,615) or an attenuated varicella virus derived therefrom. The attenuated Oka strain is deposited under the deposition number VR-795 on Mar. 14, 1975 with ATCC.

(d) Parental Oka strain: Parental Oka strain is the originally isolated, wild-type (virulent) varicella virus Oka strain.

(e) Quality control: For assuring the effectiveness, safety and uniformity of a vaccine, raw materials for a vaccine, intermediates obtained during the production of a vaccine, and final products are subjected to various tests or analyses for confirming and assuring their qualification as a vaccine. With respect to an attenuated varicella live vaccine, at present, the quality control of the vaccine is conducted in accordance with Pharmaceutical Affairs Law (the Law No. 145 established in 1960), Article 42, Item 1 and a provision entitled “Dried Attenuated Varicella Virus Live Vaccine” in the Notification No. 217 of the Japanese Ministry of Health and Welfare: Seibutsugakuteki Seizai Kijun (Minimum Requirements for Biological Products) or the above-mentioned “Requirements for Varicella Vaccine (Live)” of WHO.

(f) Nucleotide number of a DNA sequence: In the present invention, all nucleotide numbers of the varicella viruses are in accordance with the nucleotide numbering system of the nucleotide sequence of the genomic DNA of the varicella virus Dumas strain (Journal of General Virology, 67, 1759-1816, 1986 and GenBank (National Center for Biotechnology Information, National Library of Medicine, Building 38A, Room 8N805, Bethesda, Md. 20894, USA), Accession No. X04370) which is shown in SEQ ID NO: 1. Further, in the present invention, the nucleotide sequences are the sequences of a sense strand unless otherwise specified.

(g) DNA mutation: Mutations in the genomic DNA of the attenuated Oka strain were identified by conducting homology searches among the nucleotide sequences of the attenuated Oka strain, the Dumas strain and the virulent parental Oka strain. For example, the DNA mutation is described as follows: “The nucleotide A which is the 5,745th nucleotide of the Dumas strain and a nucleotide at a corresponding site of the parental Oka strain has been mutated to G in the attenuated Oka strain. This nucleotide mutation is a nonsynonymous substitution in which Ser is replaced with Pro.”

DETAILED DESCRIPTION OF THE INVENTION

In an aspect of the present invention, there is provided an accurate method for the quality control of an attenuated varicella live vaccine.

For easy understanding of the present invention, the essential features and various embodiments of the present invention are enumerated below.

1. A method for the quality control of an attenuated varicella live vaccine, which comprises subjecting the genomic DNA of a sample varicella vaccine virus to sequence analysis and confirming that the genomic DNA of the sample varicella vaccine virus conserves without suffering mutation the following 5 nucleotides:

the 5,745th G, the 105,356th C, the 105,544th G, the 106,262nd C and the 107,252nd C,

wherein the nucleotide numbers are in accordance with the nucleotide numbering system of the nucleotide sequence of the genomic DNA of the varicella virus Dumas strain of SEQ ID NO: 1.

2. The method according to item 1 above, wherein the conservation of the 5 nucleotides combination is confirmed by an RFLP analysis using the following primers:

a pair of primers of SEQ ID NOs: 5 and 6 with respect to the confirmation of the 5,745th G;

a pair of primers of SEQ ID NOs: 11 and 12 with respect to the confirmation of the 105,356th C and the 105,544th G;

a pair of primers of SEQ ID NOs: 13 and 14 with respect to the confirmation of the 106,262nd C; and

a pair of primers of SEQ ID NOs: 15 and 16 with respect to the confirmation of the 107,252nd C.

3. The method according to item 1 or 2 above, which further comprises confirming that the the genomic DNA of sample varicella vaccine virus conserves without suffering mutation the following 4 nucleotides:

the 122,645th G, the 123,635th G, the 124,353rd C and the 124,541st G,

wherein the nucleotide numbers are in accordance with the nucleotide numbering system of the nucleotide sequence of the genomic DNA of the varicella virus Dumas strain of SEQ ID NO: 1.

4. The method according to item 3 above, wherein the conservation of the 4 nucleotides is confirmed by an RFLP analysis using the following primers:

a pair of primers of SEQ ID NOs: 11 and 12 with respect to the confirmation of the 124,353rd C and the 124,541st G;

a pair of primers of SEQ ID NOs: 13 and 14 with respect to the confirmation of the 123,635th G; and

a pair of primers of SEQ ID NOs: 15 and 16 with respect to the confirmation of the 122,645th G.

5. The method according to any one of items 1 to 4 above, which further comprises confirming that the genomic DNA of the sample varicella vaccine virus conserves without suffering mutation the following 49 nucleotides:

the 560th C, the 703rd Y, the 763rd Y, the 2,515th Y, the 10,900th Y, the 12,779th Y, the 19,431st Y, the 26,125th G, the 31,732nd Y, the 38,036th Y, the 39,227th K, the 58,595th R, the 59,287th R, the 64,067th R, the 71,252nd Y, the 82,225th R, the 84,091st R, the 87,280th R, the 87,306th Y, the 89,734th R, the 90,535th R, the 94,167th C, the 97,748th R, the 97,796th Y, the 101,089th R, the 105,169th R, the 105,310th R, the 105,705th C, the 106,710th R, the 107,136th C, the 107,599th R, the 107,797th R, the 108,111st C, the 108,838th R, the 109,137th R, the 109,200th R, the 111,650th R, the 118,247th Y, the 120,697th Y, the 120,760th Y, the 121,059th Y, the 121,786th G, the 122,100th Y, the 122,298th Y, the 122,761st G, the 123,187th Y, the 124,192nd G, the 124,587th Y and the 124,728th Y,

wherein:

the nucleotide numbers are in accordance with the nucleotide numbering system of the nucleotide sequence of the genomic DNA of the varicella virus Dumas strain of SEQ ID NO: 1,

R represents A or G,

Y represents C or T, and

K represents G or T.

6. The method according to item 5 above, wherein the conservation of the 560th C, the 26,125th G, the 94,167th C, the 105,705th C, the 107,136th C, the 108,111st C, the 121,786th G, the 122,761st G and the 124,192nd G among the 49 nucleotides is confirmed by an RFLP analysis using the following primers:

a pair of primers of SEQ ID NOs: 3 and 4 with respect to the confirmation of the 560th C;

a pair of primers of SEQ ID NOs: 7 and 8 with respect to the confirmation of the 26,125th G;

a pair of primers of SEQ ID NOs: 9 and 10 with respect to the confirmation of the 94,167th C;

a pair of primers of SEQ ID NOs: 13 and 14 with respect to the confirmation of the 105,705th C and the 124,192nd G;

a pair of primers of SEQ ID NOs: 15 and 16 with respect to the confirmation of the 107,136th C and the 122,761st G; and

a pair of primers of SEQ ID NOs: 17 and 18 with respect to the confirmation of the 108,111st C and the 121,786th G.

7. The method according to any one of items 1 to 6 above, which further comprises confirming deletion mutations in two origins of replication of the genomic DNA of the sample varicella vaccine virus,

wherein the two origins of replication are a region corresponding to the 110,087th to 110,350th nucleotides of the sense strand of the genomic DNA of the varicella virus Dumas strain of SEQ ID NO: 1 and a region corresponding to the 119,547th to 119,810th nucleotides of the genomic DNA of the antisense strand of the Dumas strain, and

wherein the deletion mutations occur with respect to segments each having a nucleotide sequence of ATATATATA arranged in the direction of from the 5′ end to the 3′ end, the segments being a segment corresponding to the 110,219th to 110,227th nucleotides of the genomic DNA of the sense strand of the Dumas strain and a segment corresponding to the 119,670th to 119,678th nucleotides of the antisense strand of the genomic DNA of the Dumas strain.

8. The method according to any one of items 1 to 7 above, which further comprises confirming that the repetitive sequence of one whole R1 region of the genomic DNA of said sample varicella vaccine virus is a nucleotide sequence of abbabba′bbb′abababx (SEQ ID NO:23) arranged in the direction of from the 5′ end to the 3′ end,

wherein:

a represents a nucleotide sequence of GGACGCGATCGACGACGA (SEQ ID NO:19);

a′ represents a nucleotide sequence of GGACGCGATTGACGACGA (SEQ ID NO:20);

b represents a nucleotide sequence of GGGAGAGGCGGAGGA (SEQ ID NO:21);

b′ represents a nucleotide sequence of GGACGCGGCGGAGGA (SEQ ID NO:22); and

x represents a nucleotide sequence of GGA,

wherein said whole R1 region is a region corresponding to the 13,937th to 14,242nd nucleotides of the genomic DNA of the varicella virus Dumas strain of SEQ ID NO: 1.

9. The method according to any one of items 1 to 8 above, which further comprises confirming that the repetitive sequence of each of two whole R4 regions of the genomic DNA of said sample varicella vaccine virus is a nucleotide sequence of aaaaaaaaaaaax (SEQ ID NO:26) arranged in the direction of from the 5′ end to the 3′ end,

wherein:

a represents a nucleotide sequence of CCCCGCCGATGGGGAGGGGGCGCGGTA (SEQ ID NO:24); and

x represents a nucleotide sequence of CCCCGCCGATG (SEQ ID NO:25)

wherein said two whole R4 regions are a region corresponding to the 109,762nd to 109,907th nucleotides of the sense strand of the genomic DNA of the varicella virus Dumas strain of SEQ ID NO: 1 and a region corresponding to the 119,990th to 120,135th nucleotides of the antisense strand of the genomic DNA of said Dumas strain.

10. An attenuated varicella live vaccine which is quality-controlled by the method of any one of items 1 to 9 above.

11. A virus strain capable of functioning as an attenuated varicella vaccine virus, which is identified by a method used in the method of any one of items 1 to 9 above.

The present invention is described in detail below.

During the course of studies for completing the method of the present invention, the present inventors determined for the first time the whole nucleotide sequence of the genomic DNA of the attenuated Oka strain (deposited under the deposition number VR-795 on Mar. 14, 1975 with ATCC (American Type Culture Collection; 10801 University Boulevard, Manassas, Va. 20110-2209, USA)). This sequence is shown in SEQ ID NO:2. Further, using the determined whole genomic DNA sequence of the attenuated Oka strain, the present inventors conducted a homology search among the whole genomic DNA sequences of the Dumas strain, the parental Oka strain and the attenuated Oka strain. As a result, the present inventors disclosed the nucleotide mutations of the attenuated Oka strain (i.e., the nucleotides of the attenuated Oka strain which are different from the nucleotides of the Dumas strain and/or the parental Oka strain at the corresponding sites) shown in Table 1 below. The present inventors made further analyses of the nucleotide mutations and identified the synonymous substitutions (no amino acid replacement resulting from the nucleotide mutations) and nonsynonymous substitutions (amino acid replacements resulting from the nucleotide mutations); mutations in noncoding regions (ncr mutation); stop codon mutations (ochre/amber mutation); number of repetitions and the sequence size of the repetitive sequences and the differences in the order of the repetitions; and mutations in the origins of replication (inverted repeats; see FIG. 1 ). As explained in detail below, the mutations of the attenuated Oka strain which have been disclosed by the present inventors are useful for differentiating the attenuated Oka strain from other varicella virus strains, especially from the virulent strains and, therefore, theses mutations can be used for the quality control of the attenuated varicella live vaccine.

Among the nucleotide mutations of the attenuated Oka strain shown in Table 1, the important mutations show the XXY pattern or the XX(X/Y) pattern. The mutation showing the XXY pattern is a mutation wherein a nucleotide of the parental Oka strain is identical to a corresponding nucleotide of the Dumas strain (that is, both nucleotides are “X”), but the corresponding nucleotide of the attenuated Oka strain is a mutated nucleotide (that is, the nucleotide is mutated to “Y”). Such a mutation is unique to the attenuated Oka strain. The mutation showing the XX(X/Y) pattern is a mutation wherein a nucleotide of the parental Oka strain is identical to a corresponding nucleotide of the Dumas strain (that is, both nucleotides are “X”), but a corresponding nucleotide of the attenuated Oka strain is a mixture of a nucleotide which is identical to that of the Dumas strain and a mutated nucleotide (that is, the mixture of the identical nucleotide “X” and the mutated nucleotide “Y”). In the genome of the attenuated Oka strain, there are 18 nucleotide mutations showing the XXY pattern and 40 nucleotide mutations showing the XX(X/Y) pattern. Among the total of 58 nucleotide mutations, 49 nucleotide mutations are found in the coding regions, 8 nucleotide mutations are found in the noncoding regions, and 1 nucleotide mutation is found in a stop codon. Further, among the 49 nucleotide mutations in the coding regions, 29 nucleotide mutations are nonsynonymous substitutions, and 20 nucleotide mutations are synonymous substitutions. Further detailed analyses revealed that among the 18 nucleotide mutations showing the XXY pattern, 9 nucleotide mutations are nonsynonymous substitutions, 8 nucleotide mutations are synonymous substitutions, and 1 nucleotide mutation is found in a noncoding region. The following nucleotide mutations which show the XXY pattern and are nonsynonymous substitutions are unique to the attenuated Oka strain: the 5,745th G of gene 6; the 105,356th C, 105,544th G, 106,262nd C and 107,252nd C of gene 62; and the 122,645th G, 123,635th G, 124,353rd C and 124,541st G of gene 71. These unique nucleotides of the attenuated Oka strain are considered to be closely related to the attenuation and safety of a varicella virus and, thus these nucleotide are very important. Among the above-mentioned 9 nucleotides, 4 nucleotides are found in gene 62 and 4 nucleotides are found in gene 71. Since gene 62 and gene 71 are contained in the inverted repeats (see FIG. 1 ), in the present invention, the quality control of an attenuated varicella live vaccine is conducted by subjecting the genomic DNA of a sample varicella vaccine virus to sequence analysis and confirming that the above-mentioned 1 nucleotide of gene 6 and 4 nucleotides of gene 62 are conserved without suffering mutation. For improving the exactness of the quality control, it is preferred that the sample virus is further confirmed to conserve the above-mentioned 4 nucleotides of gene 71 without suffering mutation.

Further in the present invention, it is preferred to confirm that the sample varicella vaccine virus conserves, without suffering mutation, all 58 nucleotides which are unique to the attenuated Oka strain. Specifically, together with the above-mentioned unique nucleotides of the attenuated Oka strain which show the XXY pattern and are nonsynonymous substitutions, the conservation of the following 49 nucleotides without suffering mutation is confirmed in the present invention:

the 560th C, the 703rd Y, the 763rd Y, the 2,515th Y, the 10,900th Y, the 12,779th Y, the 19,431st Y, the 26,125th G, the 31,732nd Y, the 38,036th Y, the 39,227th K, the 58,595th R, the 59,287th R, the 64,067th R, the 71,252nd Y, the 82,225th R, the 84,091st R, the 87,280th R, the 87,306th Y, the 89,734th R, the 90,535th R, the 94,167th C, the 97,748th R, the 97,796th Y, the 101,089th R, the 105,169th R, the 105,310th R, the 105,705th C, the 106,710th R, the 107,136th C, the 107,599th R, the 107,797th R, the 108,111st C, the 108,838th R, the 109,137th R, the 109,200th R, the 111,650th R, the 118,247th Y, the 120,697th Y, the 120,760th Y, the 121,059th Y, the 121,786th G, the 122,100th Y, the 122,298th Y, the 122,761st G, the 123,187th Y, the 124,192nd G, the 124,587th Y and the 124,728th Y,

wherein, R represents A or G, Y represents C or T, and K represents G or T.

In addition to the above-mentioned 58 nucleotide mutations, the following unique mutations of the attenuated Oka strain were found by the homology search conducted among the whole genomic DNA sequences of the Dumas strain, the parental Oka strain and the attenuated Oka strain: a deletion mutation in the origin of replication, a mutation in the repetitive region R1 of gene 11 and a mutation in the repetitive region R4 of the noncoding regions.

In a varicella virus genome, there are two origins of replication which are contained in the inverted repeats (see FIG. 1 ) The origins of replication are a region corresponding to the 110,087th to 110,350th nucleotides of the sense strand of the genomic DNA of the Dumas strain and a region corresponding to the 119,547th to 119,810th nucleotides of the antisense strain of the genomic DNA of the Dumas strain. The nucleotide sequence of the sense strand is shown in Table 4. As is apparent from Table 4, the deletion in the origins of replication of the attenuated Oka strain occur with respect to segments each having a nucleotide sequence of TATATATATATATA (SEQ ID NO:27) arranged in the direction of from the 5′ end to the 3′ end, and the segments are a segment corresponding to the 110,214th to 110,227th nucleotides of the sense strand and a segment corresponding to the 119,670th to 119,683rd nucleotides of the antisense strand. In the present invention, it is preferred that the presence of this deletion is further confirmed. Specifically, this deletion can be confirmed by determining the presence or absence of the segments each having a nucleotide sequence of ATATATATA which correspond to the 110,219th to 110,227th nucleotides of the sense strand and the 119,670th to 119,678th nucleotides of the antisense strand.

The repetitive region R1 of gene 11 is a region corresponding to the 13,937th to 14,242nd nucleotides of the genomic DNA of the Dumas strain, and the nucleotide sequence of the R1 region is shown in Table 5. As is apparent from Table 5, the nucleotide sequence of the R1 region of the attenuated Oka strain is different from that of not only the Dumas strain, but also the parental Oka strain. Therefore, for the quality control of the vaccine, it is preferred that the R1 region of the sample varicella vaccine virus is confirmed to be identical with the R1 region of the attenuated Oka strain. Specifically, it is confirmed that the repetitive sequence of one whole R1 region of the genomic DNA of the sample varicella vaccine virus is a nucleotide sequence of abbabba′bbb′abababx (SEQ ID NO:23) arranged in the direction of from the 5′ end to the 3′ end (wherein, a represents a nucleotide sequence of GGACGCGATCGACGACGA (SEQ ID NO:19); a′ represents a nucleotide sequence of GGACGCGATTGACGACGA (SEQ ID NO:20); b represents a nucleotide sequence of GGGAGAGGCGGAGGA (SEQ ID NO:21); b′ represents a nucleotide sequence of GGACGCGGCGGAGGA (SEQ ID NO:22); and x represents a nucleotide sequence of GGA).

In a varicella virus genome, two repetitive regions R4 which are contained in the inverted repeats are found in the noncoding regions (see FIG. 1 ). The R4 regions are a region corresponding to the 109,762nd to 109,907th nucleotides of the sense strand of the genomic DNA of the Dumas strain and a region corresponding to the 119,990th to 120,135th nucleotides of the antisense strand of the genomic DNA of the Dumas strain. The nucleotide sequence of the R4 region in the direction of the 5′ end to the 3′ end is shown in Table 7. As is apparent from Table 7, the repetitive sequence of the R4 region of the attenuated Oka strain is different from that of not only the Dumas strain, but also the parental Oka strain. Therefore, for the quality control of the vaccine, it is preferred that the R4 region of the sample varicella vaccine virus is confirmed to be identical with the R4 region of the attenuated Oka strain. Specifically, it is confirmed that the repetitive sequence of each of two whole R4 regions of the genomic DNA of the sample varicella vaccine virus is a nucleotide sequence of aaaaaaaaaaaax (SEQ ID NO:26) arranged in the direction of from the 5′ end to the 3′ end (wherein, a represents a nucleotide sequence of CCCCGCCGATGGGGAGGGGGCGCGGTA (SEQ ID NO:24); and x represents a nucleotide sequence of CCCCGCCGATG (SEQ ID NO:25)).

In addition, the mutations shown in Table 6 have been found in the repetitive region R3 of gene 22. However, as is apparent from Table 6, there is a large diversity among the repetitive sequences of the R3 region of the attenuated Oka strain and the parental Oka strain.

The method of the present invention has been completed based on the above-mentioned nucleotide mutations which are unique to the attenuated Oka strain. Therefore, the methods used in the methods for the quality control of the present invention can be used not only for the quality control of an attenuated varicella virus live vaccine (that is, determining whether a seed virus for a vaccine, an attenuated varicella virus as a raw material of a vaccine or a live vaccine has been mutated or not), but also for the identification of a virus strain capable of functioning as an attenuated varicella vaccine virus (a virus which can be used as an active ingredient of a varicella vaccine) and the analysis of a virulent strain (the parental Oka strain or a natural wild-type strain). In addition, the method of the present invention provides an exact and advantageous techniques to be used for tracing the effects of the vaccination and for the researches in the field of epidemiology of varicella and zoster, and also provides an exact measure for preventing varicella and zoster.

The specific methods for conducting the quality control of the present invention will be described in detail below.

Preparation of a genomic DNA of a sample varicella virus: In the method of the present invention, a virus suspension or a bulk vaccine solution for use as an active ingredient of an attenuated varicella live vaccine, a virus suspension obtained by propagating a desired VZV, and vesicle fluid and the like obtained from a naturally infected varicella patient can be used as a sample varicella virus. The genomic DNA can be extracted and purified directly from the sample viruses by a conventional method. Alternatively, cells can be infected with VZV to be used as the sample virus, and the genomic DNA of the virus can be extracted and purified from the infected cells by a conventional method (with respect to the methods for extracting and purifying a DNA, reference can be made to “Current Protocol in Molecular Biology”, Volume 1, Chapter 2, 2.0.1-2.6.12, John Wiley & Sons, Inc., 1987-2000 (the loose-leaf system)). For propagating the VZV, WI-38 cells and MRC-5 cells can be used. It is preferred that the vesicle fluid used as a material for isolating, propagating and preparing a fresh wild-type strain or an epidemic strain is obtained from a naturally infected patient within 3 days after the onset of varicella.

Preparation of PCR primers: A desired nucleotide sequence of a VZV genomic DNA can be amplified by a PCR method. First, polynucleotide strands consisting of contiguous sequences of about 15 to 30 nucleotides which correspond to the 5′-terminal sequence of the sense and antisense sequences of the desired region are prepared by a DNA synthesizer. The prepared polynucleotide strands are used as a pair of primers. The whole genomic DNA sequence of the attenuated Oka strain shown in SEQ ID NO:2 and the patent documents mentioned under “Prior Art” of the specification (U.S. Pat. No. 6,093,535 and International Application Publication WO 00/50603) can be reffered when designing the PCR primers.

Determination of the nucleotide sequence of the PCR products: From the view point of saving labor for conducting the experiments, it is preferred that the PCR products are analyzed by a direct DNA sequencing method without the preparation of a genomic DNA library (this method is described in “Current Protocol in Molecular Biology”, Volume 3, Chapter 15, 15.2.1-15.2.11, ditto). In this method, the sequencing of a nucleotide sequence can be determined by conventional methods, for example, dideoxy method, a method using Cycle Sequence Kit (manufactured and sold by TAKARA SHUZO Co. Ltd., Japan), and a method using DNA Sequencing Kit (manufactured and sold by Perkin Elmer Applied Biosystems, USA).

Homology search of DNA sequences: Homology search of DNA sequences can be performed using commercially available computer software for gene analysis. For example, GENETYX-WIN (ver. 3.1) (manufactured and sold by Software Development Co., Ltd., Japan), DNASIS (ver. 3.7) (manufactured and sold by Hitachi Software Engineering Co., Ltd., Japan), FASTA (http://www.ddjb.nig.ac.jp/), and BLAST (http://www.ncbi.nlm.nih.gov/) can be used. Whether or not a sample varicella vaccine virus has a specific nucleotide sequence of the attenuated varicella Oka strain disclosed in the present specification can be determined by a homology search.

Confirmation of a nucleotide mutation by an RFLP analysis: In addition to the homology search conducted after determining the (whole or partial) nucleotide sequence of the genomic DNA of a sample virus, an RFLP (Restriction Fragment Length Polymorphism) analysis can be conducted to confirm that the unique nucleotides of the attenuated Oka strain are conserved by the sample virus without suffering mutation. Specifically, polynucleotide strands consisting of contiguous sequences of about 15 to 30 nucleotides which correspond to the 5′-terminal sequence of the sense and antisense sequences of the desired region are prepared by a DNA synthesizer, and the prepared polynucleotide strands are used as a pair of PCR primers. A pair of PCR primers are simultaneously used for amplifying the desired region to be used as a sample DNA. Thus obtained sample DNA is digested with a restriction enzyme and applied to a gel electrophoresis. The presence of a mutation can be determined by the difference in the size of the detected DNA fragments. The RFLP analysis which is easier to perform than the homology search is preferably used in the method for the quality control of the present invention. With respect to the 9 specific nucleotide mutations of the attenuated Oka strain which show the XXY pattern and are nonsynonymous substitutions (the 5,745th G, the 105,356th C, the 105,544th G, the 106,262nd C, the 107,252nd C, the 122,645th G, the 123,635th G, the 124,353rd C and the 124,541st G), and the 560th C, the 26,125th G, the 94,167th C, the 105,705th C, the 107,136th C, the 108,111st C, the 121,786th G, the 122,761st G and the 124,192nd G among the remaining 49 nucleotide mutations of the attenuated Oka strain, the presence or the absence of the mutations can be determined by the RFLP analysis using the eight primer pairs shown in Table 8 (SEQ ID NOs: 3 to 18). The restriction sites of the PCR products obtained by using the PCR primers shown in Table 8 are summarized in Table 9, together with the sizes of the restriction fragments. For example, the mutation of gene 6 (the 5,745th nucleotide G found in gene 6 of the attenuated Oka strain) can be detected by the absence or presence of the restriction enzyme Alu I site. Specifically, 763 bp DNA fragment corresponding to the 5,372nd to 6,134th nucleotides of the genomic DNA of a sample varicella vaccine virus is amplified using the primers 01-N12 and 01-R13 shown in Table 8. The amplified fragment is digested with Alu I and applied to an agarose gel electrophoresis. In the case of a virulent strain, the PCR product is cleaved into three fragments (170 bp, 205 bp and 388 bp). On the other hand, the PCR product of the attenuated Oka strain is cleaved into two fragments (170 bp and 593 bp). Therefore, whether or not a sample varicella vaccine virus is a virus capable of functioning as a vaccine strain can be determined from the restriction-fragment pattern.

In the present invention, the 9 unique nucleotide mutations of the attenuated Oka strain which show the XXY pattern and are nonsynonymous substitutions are preferably confirmed by the RFLP analysis using the following primers: a pair of primers of SEQ ID NOs: 5 and 6 with respect to the confirmation of the 5,745th G; a pair of primers of SEQ ID NOs: 11 and 12 with respect to the confirmation of the 105,356th C, the 105,544th G, the 124,353rd C and the 124,541st G; a pair of primers of SEQ ID NOs: 13 and 14 with respect to the confirmation of the 106,262nd C and the 123,635th G; and a pair of primers of SEQ ID NOs: 15 and 16 with respect to the confirmation of the 107,252nd C and the 122,645th G. Since gene 62 and gene 71 are inverted repeats (see FIG. 1 ), the quality control of an attenuated varicella live vaccine can be conducted by confirming the conservation of at least 5 nucleotides (namely 1 nucleotide of gene 6 and 4 nucleotides of gene 62) by the RFLP analysis.

As mentioned above, the whole genomic DNA sequence of the attenuated Oka strain (SEQ ID NO:2) and the nucleotide mutations which are unique to the attenuated Oka strain have been disclosed for the first time by the present inventors. Since the unique nucleotide mutations of the attenuated Oka strain are considered to be very important for the attenuation of a varicella viruses, an attenuated strain can be constructed by introducing a nucleotide substitution to a genomic DNA of a virulent strain (for example a wild type VZV strain or an epidemic strain), or by inducing an amino acid mutation in a virulent strain. The method described in Proc. Natl. Acad. Sci., USA, 90(15), 7376-7380, 1998 can be used as a genetic engineering technique for inducing a nucleotide or amino acid mutation. Specifically, the 58 nucleotide mutations which are unique to the attenuated Oka strain can be used as an index for inducing a mutation to a virulent strain, and the 9 nucleotide substitutions which are nonsynonymous substitutions are especially useful. In addition, taking into account the fact that gene 62 and gene 71 are contained in the inverted repeats (see FIG. 1 ), among the above-mentioned nucleotide substitutions, at least 5 nucleotide mutations (namely a mutation found in gene 6 and the mutations found in either gene 62 or gene 71) are considered to be very important.

BEST MODE FOR CARRYING OUT THE INVENTION

Hereinbelow, the present invention will be described in more detail with reference to the following Examples, but they should not be construed as limiting the scope of the present invention.

Example 1

The attenuated Oka strain (attenuated vaccine strain) and its parental strain (parental Oka strain; a virulent strain which is not attenuated) were individually inoculated into MRC-5 cells to thereby obtain infected cells. The genomic DNAs of the attenuated Oka strain and the parental Oka strain were extracted individually from the infected cells by phenol extraction and chloroform/isoamyl alcohol extraction, and purified by ethanol precipitation, thereby obtaining DNA. PCR products covering the entire genome of each strain were prepared using the obtained DNA as a template and 88 synthetic primers (44 primer pairs). Subsequently, the nucleotide sequences of the PCR products were determined by the direct DNA sequencing method using 520 synthetic primers and the DNA Sequencing Kit (manufactured and sold by Perkin Elmer Applied Biosystems, USA). Using the whole genomic sequence of the Dumas strain (virulent strain) shown in SEQ ID NO: 1 as a standard, the homology search was conducted with respect to the obtained whole genomic DNA sequences of the attenuated Oka strain and the parental Oka strain. DNASIS (version 3.7) (manufactured and sold by Hitachi Software Engineering Co., Ltd., Japan) was used for conducting the homology search. The characteristics of the attenuated Oka strain which became apparent from the homology search are summarized in Tables 1 to 7.

The nucleotide mutations which were detected by comparing the sequences among the three varicella strains (Dumas strain, parental Oka strain and attenuated Oka strain) are listed in Table 1. Specifically, the nucleotide number, the gene number, the mutated nucleotide and the amino acid mutation caused by the nucleotide mutation are described for each nucleotide mutation. In Table 1, Y represents a pyrimidine base (i.e., C or T), R represents a purine base (i.e., A or G), K represents G or T, (ncr) represents a noncoding region, an alphabet letter in parentheses (for example “(W)”) is a one-letter abbreviation of an amino acid, (och) represents ochre codon, (amb) represents amber codon, (W/R) represents tryptophan (W) or arginine (R), and (del) represents deletion.

Among the mutations listed in Table 1, the mutations which were detected by the sequence alignment between the attenuated Oka strain and the parental Oka strain are listed in Table 2. Specifically, the nucleotide number, the gene number, the mutated nucleotide and the amino acid mutation caused by the nucleotide mutation are described for each nucleotide mutation. In Table 2, X/Y represents X or Y, and a three-letter abbreviation of an amino acid encoded by a nucleotide is shown in parentheses following the nucleotide (when a nucleotide is located in a noncoding region, the nucleotide is followed by “(ncr)”). All other abbreviations used in Table 2 are the same as those used in Table 1.

The nucleotide mutations described in Tables 1 and 2 are summarized in Table 3, based on the mutation patterns. The mutation patterns and abundance thereof are listed together with the details of the mutation patterns, that is, the specific types of mutation (a stop codon (och/amb) mutation, a synonymous or nonsynonymous substitution, and deletion (or addition)) and the abundance of each type of mutation.

The findings based on Tables 1 to 3 are explained in detail below.

Among the major nucleotide and amino acid mutations which were determined by the comparison between the whole genomic DNA sequences of the attenuated Oka strain and the parental Oka strain, the mutations described in the following items (a) to (f) were found to be especially useful and important for the quality control of an attenuated varicella live vaccine.

(a) There were 58 important nucleotide mutations of the attenuated Oka strain, namely 18 nucleotide mutations showing the XXY pattern and 40 nucleotide mutations showing the XX(X/Y) pattern.

(b) Among the above-mentioned 58 mutations, 49 mutations were found in the coding regions, 8 mutations were found in the noncoding regions and 1 mutation was found in a stop codon.

(c) Among the 49 mutations found in the coding regions, 29 mutations were nonsynonymous substitutions and 20 mutations were synonymous substitutions.

(d) Among the 18 mutations showing the XXY pattern, 9 mutations were nonsynonymous substitutions, 8 mutations were synonymous substitutions, and 1 mutation was found in a noncoding region.

(e) The above-mentioned 9 mutations showing the XXY pattern which are nonsynonymous substitutions (namely the 5,745th nucleotide G of gene 6; the 105,356th nucleotide C, the 105,544th nucleotide G, the 106,262nd nucleotide C and the 107,252nd nucleotide C of gene 62; and the 122,645th nucleotide G, the 123,635th nucleotide G, the 124,353rd nucleotide C and the 124,541st nucleotide G of gene 71) can be used as markers for the attenuation or safety of a virus strain capable of functioning as an active ingredient of a live vaccine. Therefore, these nucleotide mutations are useful and important for the quality control of a vaccine. It should be noted that gene 62 and gene 71 are contained in the inverted repeats (see FIG. 1 ).

(f) 40 nucleotides of the vaccine strain showed the XX(X/Y) pattern (that is, a mutation pattern wherein the virus strain is a mixture of a virus having nucleotide X and a virus having nucleotide Y). When the attenuated Oka strain was subcultured experimentally (i.e., the virus was passaged 5 times, 10 times, 17 times and the like), all the nucleotides of the XX(X/Y) pattern, except for the 106,710th nucleotide, showed the following tendency. The detection frequency of nucleotide Y increased in accordance with the number of passages (that is, the nucleotide changed from X/Y to Y) and the mutation pattern of the nucleotide converged to the XXY pattern. In other words, the ratio of X to Y (x/y) decreased in accordance with the number of passages. Based on the above-mentioned phenomenon, it is considered that the number of passages of a seed virus used in a seed lot system can be estimated by measuring the x/y value. It should be noted that among the above-mentioned mutations, 20 mutations converged to nonsynonymous substitutions. With respect to the remainder of the mutations, 12 mutations were synonymous substitutions, 1 mutation was found in a stop codon (specifically, an ochre codon/amber codon mixture converged to an amber mutation), and 7 mutations were found in the noncoding regions.

TABLE 1
Nucleotide				Parental	Attenuated
no.	Gene no.	Dumas	strain	Oka strain	Oka strain
1	5′/gene 1	A	(ncr)	G	(ncr)	G	(ncr)
3	5′/gene 1	G	(nor)	C	(ncr)	C	(ncr)
117	5′/gene 1	C	(ncr)	del		del
236	5′/gene 1	A	(ncr)	G	(ncr)	G	(ncr)
262	5′/gene 1	C	(ncr)	T	(ncr)	T	(ncr)
560	5′/gene 1	T	(ncr)	T	(ncr)	C	(ncr)
685	gene 1	G	(N)	A	(N)	A	(N)
703	gene 1	T	(Q)	T	(Q)	Y	(Q)
763	gene 1	T	(P)	T	(P)	Y	(P)
789	gene 1	T	(T)	C	(A)	C	(A)
790-1	gene 1	TT	(Q)	CC	(R)	CC	(R)
2515	gene 3/4	T	(ncr)	T	(ncr)	Y	(ncr)
3764	gene 4	A	(T)	G	(T)	G	(T)
4258	gene 5	C	(K)	T	(K)	T	(K)
5745	gene 6	A	(S)	A	(S)	G	(P)
6853	gene 6	G	(H)	T	(Q)	T	(Q)
7091	gene 6	C	(G)	A	(V)	A	(V)
7753	gene 6	C	(P)	T	(P)	T	(P)
9460	gene 7/8	T	(ncr)	C	(ncr)	C	(ncr)
10079	gene 8	G	(P)	A	(S)	A	(S)
10900	gene 9A	T	(W)	T	(W)	Y	(W/R)
11890	gene 9	T	(S)	G	(S)	G	(S)
11906	gene 9	A	(T)	G	(A)	G	(A)
12188	gene 10	C	(P)	A	(H)	A	(H)
12284	gene 10	T	(F)	C	(S)	C	(S)
12285	gene 10	T	(F)	C	(S)	C	(S)
12779	gene 10	C	(A)	C	(A)	Y	(A/V)
13173	gene 10	T	(G)	G	(G)	G	(G)
13407	gene 10/11	G	(ncr)	A	(ncr)	A	(ncr)
14390	gene 11	T	(C)	C	(C)	C	(C)
17404	gene 12	C	(V)	T	(V)	T	(V)
17834	gene 12	C	(L)	T	(L)	T	(L)
18082	gene 12	C	(T)	T	(T)	T	(T)
18467	gene 13	G	(K)	A	(K)	A	(K)
19431	gene 14	T	(o)	T	(o)	Y	(o/a)
19719	gene 14	A	(I)	G	(I)	G	(I)
20656	gene 14	T	(Y)	A	(F)	A	(F)
20684	gene 14	T	(T)	C	(A)	C	(A)
21371	gene 15	G	(L)	A	(L)	A	(L)
21734	gene 15	G	(R)	T	(R)	T	(R)
22311	gene 15	G	(S)	A	(S)	A	(S)
22504	gene 15/16	A	(ncr)	G	(ncr)	G	(ncr)
22794	gene 16	A	(M)	G	(T)	G	(T)
23294	gene 16	A	(F)	G	(F)	G	(F)
24515-7	gene 17	TCA	(S)	del		del
24578	gene 17	A	(T)	G	(A)	G	(A)
24654	gene 17	C	(T)	T	(M)	T	(M)
25067	gene 17	G	(V)	A	(I)	A	(I)
26125	gene 18	A	(N)	A	(N)	G	(N)
27523	gene 19	A	(H)	G	(H)	G	(H)
29201	gene 20	T	(G)	C	(G)	G	(G)
31732	gene 21	C	(T)	C	(T)	Y	(T/I)
32274	gene 21	A	(T)	G	(A)	G	(A)
33722	gene 21	T	(H)	C	(H)	C	(H)
33725	gene 21	T	(D)	C	(D)	C	(D)
33728	gene 21	T	(N)	C	(N)	C	(N)
35543	gene 22	T	(V)	C	(V)	C	(V)
37649	gene 22	A	(L)	G	(L)	G	(L)
37902	gene 22	A	(I)	G	(V)	G	(V)
38036	gene 22	T	(T)	T	(T)	Y	(T)
38055	gene 22	T	(V)	C	(H)	C	(H)
38081	gene 22	A	(P)	C	(P)	C	(P)
38177	gene 22	G	(E)	A	(E)	A	(E)
38714	gene 22	G	(T)	T	(T)	T	(T)
38717	gene 22	C	(A)	T	(A)	T	(A)
39023	gene 22	A	(R)	G	(R)	G	(R)
39227	gene 22	T	(P)	T	(P)	K	(P)
39263	gene 22	G	(Q)	A	(Q)	A	(Q)
39394	gene 22	G	(R)	A	(H)	A	(H)
39530	gene 22	A	(V)	G	(V)	G	(V)
40388	gene 22	A	(Q)	G	(Q)	G	(Q)
41057	gene 22	T	(P)	C	(P)	C	(P)
41452	gene 22	G	(R)	A	(Q)	A	(Q)
41618	gene 22	C	(T)	T	(T)	T	(T)
41764	gene 22	G	(S)	A	(N)	A	(N)
42069	gene 22	C	(Q)	G	(E)	G	(E)
42176	gene 22	C	(R)	T	(R)	T	(R)
42242	gene 22	A	(A)	C	(A)	C	(A)
42401-3	gene 22/23	AAA	(ncr)	del		del
42476	gene 23	T	(S)	G	(S)	G	(S)
43262	gene 24	T	(I)	C	(V)	C	(V)
44835	gene 26	C	(C)	T	(C)	T	(C)
47162	gene 28	A	(C)	G	(R)	G	(R)
47940	gene 28	C	(L)	T	(L)	T	(L)
48050	gene 28	T	(S)	C	(G)	C	(G)
48825	gene 28	G	(T)	A	(T)	A	(T)
49535	gene 28	G	(L)	A	(L)	A	(L)
50081	gene 28	C	(G)	A	(C)	A	(C)
51168	gene 29	C	(S)	T	(S)	T	(S)
52917	gene 29	A	(Q)	G	(Q)	G	(Q)
53482	gene 29	A	(I)	C	(L)	C	(L)
53938	gene 29	G	(A)	A	(T)	A	(T)
54359-73	gene 29	AACATTTC	(NISGS)	del		del
		AGGGTCA
54562	gene 29/30	T	(ncr)	del	(ncr)	del	(ncr)
54564	gene 29/30	T	(ncr)	C	(ncr)	C	(ncr)
55820	gene 30	A	(P)	G	(P)	G	(P)
57224	gene 31	A	(T)	C	(P)	C	(P)
57301	gene 31	A	(A)	C	(A)	C	(A)
57397	gene 31	G	(A)	T	(A)	T	(A)
58595	gene 31	A	(I)	A	(I)	R	(I/V)
59287	gene 31	A	(P)	A	(P)	R	(P)
59760-1	gene 31/32	del	(ncr)	G	(ncr)	G	(ncr)
60276-8	gene 32/33	AAA	(ncr)	del		del
60279	gene 32/33	A	(ncr)	C	(ncr)	C	(ncr)
60405	gene 33	C	(A)	A	(A)	A	(A)
60781	gene 33	T	(Y)	G	(S)	G	(S)
61018-9	gene 33	GG	(P)	AA	(F)	AA	(F)
61201-2	gene 33	TT	(N)	CC	(G)	CC	(G)
64067	gene 35	A	(A)	A	(A)	R	(A)
64136	gene 35	A	(C)	G	(C)	G	(C)
64259	gene 35	T	(P)	C	(P)	C	(P)
64375	gene 35	T	(M)	C	(V)	C	(V)
64989	gene 36	C	(A)	T	(A)	T	(A)
65669	gene 36	C	(S)	T	(L)	T	(L)
66646	gene 37	G	(L)	T	(L)	T	(L)
66879	gene 37	C	(P)	T	(L)	T	(L)
68172	gene 37	G	(R)	A	(K)	A	(K)
69349	gene 38	A	(T)	G	(T)	G	(T)
69756	gene 38	T	(S)	C	(G)	C	(G)
71252	gene 39	T	(M)	T	(M)	Y	(M/T)
72997	gene 40	C	(V)	T	(V)	T	(V)
73993	gene 40	T	(T)	C	(T)	C	(T)
76530	gene 41	C	(V)	T	(V)	T	(V)
78144	gene 42/43	T	(ncr)	del		del
80244	gene 43/44	G	(ncr)	T	(ncr)	T	(ncr)
80840	gene 44	A	(N)	G	(D)	G	(D)
81187	gene 44	C	(A)	T	(A)	T	(A)
82225	gene 45	A	(P)	A	(P)	R	(P)
84091	gene 47	G	(E)	G	(E)	R	(E)
84616	gene 47	A	(T)	G	(T)	G	(T)
84983	gene 48	G	(R)	A	(H)	A	(H)
85563	gene 48	C	(D)	T	(D)	T	(D)
86170	gene 48	C	(Q)	A	(K)	A	(K)
86484-93	gene 49/50	CCTGATAA	(ncr)	del	(ncr)	del	(ncr)
		AC
86556	gene 49/50	T	(ncr)	G	(ncr)	G	(ncr)
87280	gene 50	A	(C)	A	(C)	R	(C)
87306	gene 50	T	(S)	T	(S)	Y	(S/G)
87841	gene 50	C	(S)	T	(S)	T	(S)
88477	gene 51	G	(S)	T	(S)	T	(S)
89734	gene 51	A	(T)	A	(T)	R	(T)
89905	gene 51	T	(T)	C	(T)	C	(T)
90202	gene 51	G	(Q)	T	(H)	T	(H)
90217	gene 51	T	(S)	C	(S)	C	(S)
90392	gene 51/52	G	(ncr)	A	(ncr)	A	(ncr)
90535	gene 52	A	(I)	A	(I)	R	(I/V)
91191	gene 52	C	(G)	T	(G)	T	(G)
92026	gene 52	A	(T)	G	(A)	G	(A)
92092	gene 52	A	(T)	G	(A)	G	(A)
92375	gene 52	A	(H)	G	(R)	G	(R)
92999	gene 53	T	(V)	C	(V)	C	(V)
94167	gene 54	T	(L)	T	(L)	C	(L)
94632	gene 54	A	(V)	G	(V)	G	(V)
94641	gene 54	A	(T)	T	(T)	T	(T)
95241	gene 54	T	(G)	C	(G)	C	(G)
95546	gene 54	G	(L)	A	(L)	A	(L)
95601	gene 54	T	(E)	G	(D)	G	(D)
97141	gene 55	T	(L)	C	(L)	C	(L)
97591	gene 55	C	(I)	T	(I)	T	(I)
97748	gene 55	G	(A)	G	(A)	R	(A/T)
97796	gene 55	T	(C)	T	(C)	Y	(C/R)
98437	gene 55	T	(G)	C	(G)	C	(G)
98765	gene 56	A	(V)	C	(V)	C	(V)
98807	gene 56	A	(T)	C	(T)	C	(T)
99226-8	gene 56	CTT	(S)	del		del
99421	gene 57	T	(H)	G	(P)	G	(P)
99709	gene 57	A	(Y)	G	(Y)	G	(Y)
99981	gene 58	C	(V)	T	(K)	T	(K)
100114	gene 58	T	(K)	A	(N)	A	(N)
100151	gene 58	T	(N)	G	(T)	G	(T)
100283	gene 58/59	A	(ncr)	G	(ncr)	G	(ncr)
101089	gene 59	A	(L)	A	(L)	R	(L/P)
101331	gene 60	C	(A)	T	(T)	T	(T)
101623-4	gene 60	del		ATC	(H)	ATC	(H)
101886	gene 60/61	T	(ncr)	C	(ncr)	C	(ncr)
101991	gene 60/61	C	(ncr)	T	(ncr)	T	(ncr)
102192	gene 60/61	G	(ncr)	A	(ncr)	A	(ncr)
102203	gene 60/61	A	(ncr)	G	(ncr)	G	(ncr)
102309	gene 6o/61	C	(ncr)	A	(ncr)	A	(ncr)
102351	gene 60/61	A	(ncr)	C	(ncr)	C	(ncr)
102458	gene 60/61	A	(ncr)	G	(ncr)	G	(ncr)
102601	gene 60/61	T	(ncr)	G	(ncr)	G	(ncr)
103043	gene 60/61	T	(ncr)	C	(ncr)	C	(ncr)
104898	gene 61/62	A	(ncr)	G	(ncr)	G	(ncr)
105009-10	gene 61/62	del		G	(ncr)	G	(ncr)
105012	gene 61/62	T	(ncr)	C	(ncr)	C	(ncr)
105015	gene 61/62	T	(ncr)	C	(ncr)	C	(ncr)
105017	gene 61/62	T	(ncr)	C	(ncr)	C	(ncr)
105054	gene 61/62	G	(ncr)	del		del
105071	gene 61/62	G	(ncr)	del		del
105151-2	gene 61/62	del	(ncr)	ACAA	(ncr)	ACAA	(ncr)
105169	gene 61/62	A	(ncr)	A	(ncr)	R	(ncr)
105310	gene 62	A	(L)	A	(L)	R	(L/S)
105312	gene 62	A	(G)	G	(G)	G	(G)
105356	gene 62	T	(I)	T	(I)	C	(V)
105451	gene 62	A	(L)	G	(P)	G	(P)
105512	gene 62	A	(S)	C	(A)	C	(A)
105544	gene 62	A	(V)	A	(V)	G	(A)
105705	gene 62	T	(A)	T	(A)	C	(A)
106262	gene 62	T	(R)	T	(R)	C	(G)
106710	gene 62	A	(A)	A	(A)	R	(A)
107136	gene 62	T	(A)	T	(A)	C	(A)
107165	gene 62	C	(A)	T	(T)	T	(T)
107252	gene 62	T	(S)	T	(S)	C	(G)
107307	gene 62	T	(R)	C	(R)	C	(R)
107599	gene 62	A	(V)	A	(V)	R	(V/A)
107607	gene 62	C	(T)	A	(T)	A	(T)
107715	gene 62	T	(A)	C	(A)	C	(A)
107797	gene 62	A	(L)	A	(L)	R	(L/P)
108111	gene 62	T	(P)	T	(P)	G	(P)
108747	gene 62	A	(L)	G	(L)	G	(L)
108838	gene 62	A	(M)	A	(M)	R	(M/T)
108951	gene 62	G	(H)	A	(H)	A	(H)
109044	gene 62	C	(A)	G	(A)	G	(A)
109137	gene 62/63	A	(ncr)	A	(ncr)	R	(ncr)
109200	gene 62/63	A	(ncr)	A	(ncr)	R	(ncr)
109654	gene 62/63	G	(ncr)	T	(ncr)	T	(ncr)
109696-7	gene 62/63	del		CAT	(ncr)	CAT	(ncr)
110003	gene 62/63	G	(ncr)	A	(ncr)	A	(ncr)
110058	gene 62/63	G	(ncr)	del		del
110112	gene 62/63	G	(ncr)	A	(ncr)	A	(ncr)
110378	gene 62/63	G	(ncr)	del		del
110386	gene 62/63	C	(ncr)	del		del
111312	gene 63	A	(T)	G	(T)	G	(T)
111650	gene 64	A	(Q)	A	(Q)	R	(Q/R)
112093	gene 64	T	(Y)	C	(H)	C	(H)
112137	gene 64/65	A	(ncr)	del		del
112198	gene 64/65	G	(ncr)	A	(ncr)	A	(ncr)
114140	gene 66	A	(S)	G	(S)	G	(S)
115041	gene 67	G	(P)	A	(P)	A	(P)
115926	gene 68	C	(T)	T	(I)	T	(I)
117699	gene 68/69	C	(ncr)	T	(ncr)	T	(ncr)
117760	gene 68/69	T	(ncr)	del		del
117804	gene 69	A	(Y)	G	(H)	G	(H)
118247	gene 69	T	(Q)	T	(Q)	Y	(Q/R)
118585	gene 70	T	(T)	C	(T)	C	(T)
119511	gene 70/71	G	(ncr)	del		del
119519	gene 70/71	C	(ncr)	del		del
119785	gene 70/71	C	(ncr)	T	(ncr)	T	(ncr)
119839	gene 70/71	C	(ncr)	del		del
119894	gene 70/71	C	(ncr)	T	(ncr)	T	(ncr)
120200-1	gene 70/71	del		ATG	(ncr)	ATG	(ncr)
120243	gene 70/71	C	(ncr)	A	(ncr)	A	(ncr)
120697	gene 70/71	T	(ncr)	T	(ncr)	Y	(ncr)
120760	gene 70/71	T	(ncr)	T	(ncr)	Y	(ncr)
120853	gene 71	G	(A)	C	(A)	C	(A)
120946	gene 71	C	(H)	T	(H)	T	(H)
121059	gene 71	T	(M)	T	(M)	Y	(M/T)
121150	gene 71	T	(L)	C	(L)	C	(L)
121786	gene 71	A	(P)	A	(P)	G	(P)
122100	gene 71	T	(L)	T	(L)	Y	(L/P)
122182	gene 71	A	(A)	G	(A)	G	(A)
122290	gene 71	G	(T)	T	(T)	T	(T)
122298	gene 71	T	(V)	T	(V)	Y	(V/A)
122590	gene 71	A	(R)	G	(R)	G	(R)
122645	gene 71	A	(S)	A	(S)	G	(G)
122732	gene 71	G	(A)	A	(T)	A	(T)
122761	gene 71	A	(A)	A	(A)	G	(A)
123187	gene 71	T	(A)	T	(A)	Y	(A)
123635	gene 71	A	(R)	A	(R)	G	(G)
124192	gene 71	A	(A)	A	(A)	G	(A)
124353	gene 71	T	(V)	T	(V)	C	(A)
124385	gene 71	T	(S)	G	(A)	G	(A)
124446	gene 71	T	(L)	C	(P)	C	(P)
124541	gene 71	A	(I)	A	(I)	G	(V)
124585	gene 71	T	(G)	C	(G)	C	(G)
124587	gene 71	T	(L)	T	(L)	Y	(L/S)
124728	gene 71/3′	T	(ncr)	T	(ncr)	Y	(ncr)
124745-6	gene 71/3′	del	(ncr)	TTGT	(ncr)	TTGT	(ncr)
124826	gene 71/3′	C	(ncr)	del		del
124843	gene 71/3′	C	(ncr)	del		del
124880	gene 71/3′	A	(ncr)	G	(ncr)	G	(ncr)
124882	gene 71/3′	A	(ncr)	G	(ncr)	G	(ncr)

TABLE 2
Gene	Nucleotide	Attenuated	Parental	Dumas
no.	no.	Oka strain	Oka strain	strain
1	560	C	(ncr)	T (ncr)	T (ncr)
	703	T/C	(Gln)	T (Gln)	T (Gln)
	763	T/C	(Pro)	T (Pro)	T (Pro)
3-4	2515	T/C	(ncr)	T (ncr)	T (ncr)
6	5745	G	(Pro)	A (Ser)	A (Ser)
9A	10900	T/C	(Trp/Arg)	T (Trp)	T (Trp)
10	12779	C/T	(Ala/Val)	C (Ala)	C (Ala)
14	19431	T/C	(och/amb)	T (och)	T (och)
18	26125	G	(Asn)	A (Asn)	A (Asn)
21	31732	C/T	(Thr/Ile)	C (Thr)	C (Thr)
22	38036	T/C	(Thr)	T (Thr)	T (Thr)
	39227	G/T	(Pro)	T (Pro)	T (Pro)
31	58595	A/G	(Ile/Val)	A (Ile)	A (Ile)
	59287	A/G	(Pro)	A (Pro)	A (Pro)
35	64067	A/G	(Ala)	A (Ala)	A (Ala)
39	71252	T/C	(Met/Thr)	T (Met)	T (Met)
45	82225	A/G	(Pro)	A (Pro)	A (Pro)
47	84091	A/G	(Glu)	G (Glu)	G (Glu)
50	87280	A/G	(Cys)	A (Cys)	A (Cys)
	87306	T/C	(Ser/Gly)	T (Ser)	T (Ser)
51	89734	A/G	(Thr)	A (Thr)	A (Thr)
52	90535	A/G	(Ile/Val)	A (Ile)	A (Ile)
54	94167	C	(Leu)	T (Leu)	T (Leu)
55	97748	G/A	(Ala/Thr)	G (Ala)	G (Ala)
	97796	T/C	(Cys/Arg)	T (Cys)	T (Cys)
59	101089	A/G	(Leu/Pro)	A (Leu)	A (Leu)
61-62	105169	A/G	(ncr)	A (ncr)	A (ncr)
62	105310	A/G	(Leu/Ser)	A (Leu)	A (Leu)
	105356	C	(Val)	T (Ile)	T (Ile)
	105544	G	(Ala)	A (Val)	A (Val)
	105705	C	(Ala)	T (Ala)	T (Ala)
	106262	C	(Gly)	T (Arg)	T (Arg)
	106710	A/G	(Ala)	A (Ala)	A (Ala)
	107136	C	(Ala)	T (Ala)	T (Ala)
	107252	C	(Gly)	T (Ser)	T (Ser)
	107599	A/C	(Val/Ala)	A (Val)	A (Val)
	107797	A/G	(Leu/Pro)	A (Leu)	A (Leu)
	108111	C	(Pro)	T (Pro)	T (Pro)
	108838	A/G	(Met/Thr)	A (Met)	A (Met)
62-63	109137	A/G	(ncr)	A (ncr)	A (ncr)
	109200	A/G	(ncr)	A (ncr)	A (ncr)
64	111650	A/G	(Gln/Arg)	A (Gln)	A (Gln)
69	118247	T/C	(Gln/Arg)	T (Gln)	T (Gln)
70-71	120697	T/C	(ncr)	T (ncr)	T (ncr)
	120760	T/C	(ncr)	T (ncr)	T (ncr)
71	121059	T/C	(Met/Thr)	T (Met)	T (Met)
	121786	G	(Pro)	A (Pro)	A (Pro)
	122100	T/C	(Leu/Pro)	T (Leu)	T (Leu)
	122298	T/C	(Val/Ala)	T (Val)	T (Val)
	122645	G	(Gly)	A (Ser)	A (Ser)
	122761	G	(Ala)	A (Ala)	A (Ala)
	123187	T/C	(Ala)	T (Ala)	T (Ala)
	123635	G	(Gly)	A (Arg)	A (Arg)
	124192	G	(Ala)	A (Ala)	A (Ala)
	124353	C	(Ala)	T (Val)	T (Val)
	124541	G	(Val)	A (Ile)	A (Ile)
	124587	T/C	(Leu/Ser)	T (Leu)	T (Leu)
71-3′	124728	T/C	(ncr)	T (ncr)	T (ncr)
ncr: noncoding region
X/Y: X or Y
och/amb: stop codon mutation of an ochre codon or an amber codon

TABLE 3
Pattern of	Dumas	Parental	Attenuated	Amino acid	Number of
nucleotide mutation	strain	Oka strain	Oka strain	replacement	nucleotides
XXX pattern	◯	◯	◯		124,585
XYY pattern	◯	&Circlesolid;	&Circlesolid;		189
				Synonymous	91
				Nonsynonymous	62
				ncr	36
XXY pattern	◯	◯	&Circlesolid;		18
				Synonymous	8
				Nonsynonymous	9
				ncr	1
XX(X/Y)	◯	◯	◯/&Circlesolid;		40
pattern				Synonymous	12
				Nonsynonymous	20
				ncr	7
				och/amb	1
XYX pattern	◯	&Circlesolid;	◯		0
XYZ pattern	◯	&Circlesolid;	♦		0
XDD pattern	◯	del	del		52
DXX pattern	del	◯	◯		19
XXX pattern: All three starins have the same nucleotide at anucleotide number which corresponds to the same nuclotide site (i.e. “corresponding nucleotide number”).
XYY pattern: Only the Dumas strain has a different nucleotide at the corresponding nucleotide number.
XXY pattern: Only the attenuated Oka strain has a different nucleotide at the corresponding nucleotide number.
XX(X/Y) pattern: Only the attenuated Oka strain has a nucleotide X/Y (X or Y) at the corresponding nucleotide number. Therefore, the attenuated Oka strain is a mixture of the XXX and XXY patterns. For example , with respect to the 8 mutations showing the XX(X/Y) pattern which are located in gene 62, the ratio of x to y (x/y) transiently decreased as the number of passages increased from 5 times, 10 times to 17 times, and the mutation pattern converged to the XXY pattern. However, only the 106,710th
# nucleotide A/G remained unchanged without converging from A to G.
XYX pattern: Only the parental Oka strain has a different nucleotide at the corresponding nucleotide number.
XYZ pattern: All three strains have a different nucleotide at the corresponding nucleotide number.
XDD pattern: The nucleotide at the corresponding nucleotide number is either deleted (del) in both the parental Oka strain and the attenuated Oka strain, or added in only the Dumas strain.
DXX pattern: The nucleotide at the corresponding nucleotide number is either deleted (del) in only the Dumas strain, or added in both the parental Oka strain and the attenuated Oka strain.
ncr: noncoding region
och/amb: stop codon mutation of an ochre codon or an amber codon

Table 4 shows the sequence alignment of the nucleotide sequences of the sense strand of the origin of replication of the Dumas strain, the parental Oka strain and the attenuated Oka strain. In this table, “-” represents a deletion.

In the attenuated Oka strain, deletions occur with respect to segments each having a nucleotide sequence of TATATATATATATA (SEQ ID NO:27) arranged in the direction of from the 5′ end to the 3′ end, which correspond to the 110,214th to 110,227th nucleotides of the sense strand of the genomic DNA of the Dumas strain of SEQ ID NO:1 and a segment corresponding to the 119,670th to 119,683rd nucleotides of the antisense strand of the genomic DNA of the Dumas strain. Therefore, taking into consideration the difference between the parental Oka strain and the attenuated Oka strain, it became apparent that the deletion with respect to segments ATATATATA at the 3′ end is useful for the quality control of a vaccine.

TABLE 4
  110087
D G T A C G C C A A T C G G A T A C A C T C T T T
P G T A C G C C A A T C G G A T A C A C T C T T T
V G T A C G C C A A T C G G A T A C A C T C T T T
  T G A T C T
  T A A T C T
  T A A T C T
  110117
D G C A T T C G C A C T T C C C G T T T T T T C A
P G C A T T C G C A C T T C C C G T T T T T T C A
V G C A T T C G C A C T T C C C G T T T T T T C A
  C T G T A T
  C T G T A T
  C T G T A T
  110147
D G G G T T T C A T T G T T T T G G C A T G T G T
P G G G T T T C A T T G T T T T G G C A T G T G T
V G G G T T T C A T T G T T T T G G C A T G T G T
  C C A A C C
  C C A A C C
  C C A A C C
  110177
D A C C G T T C G C A C T T T C T T T C T A T A T
P A C C G T T C G C A C T T T C T T T C T A T A T
V A C C G T T C G C A C T T T C T T T C T A T A T
  A T A T A T
  A T A T A T
  A T A T A T
  110207
D A T A T A T A T A T A T A T A T A T A T A G A G
P A T A T A T A T A T A T A - - - - - - - - G A G
V A T A T A T A - - - - - - - - - - - - - - G A G
  A A A G A G
  A G A G A G
  A G A G A G
  110237
D A G A G A G - - - - - - - - - - - - - - T T T C
P A G A G A G A G A G A G G G A G A G A G T T T C
V A G A G A G A G A - - G G G A G A G A G T T T C
  T T G T T C
  T T G T T C
  T T G T T C
  110267
D G C G C G T G T T C C C G C G A T G T C G C G G
P G C G C G T G T T C C C G C G A T G T C G C G G
V G C G C G T G T T C C C G C G A T G T C G C G G
  T T T T A T
  T T T T A T
  T T T T A T
  110297
D G G G G T G T G G G C G G G C T T T T C A C A G
P G G G G T G T G G G C G G G C T T T T C A C A G
V G G G G T G T G G G C G G G C T T T T C A C A G
  A A T A T A
  A A T A T A
  A A T A T A
  110327
D T A T A T T C C A A A T G G A G C G G C A G G C
P T A T A T T C C A A A T G G A G C G G C A G G C
V T A T A T T C C A A A T G G A G C G G C A G G C
  T T T T T A
  T T T T T A
  T T T T T A
  110357
D A A A T C G A T T
P A A A T C G A T T
V A A A T C G A T T
D: Dumas strain (SEQ ID NO:28)
P: Parental Oka strain (SEQ ID NO:29)
V: Attenuated Oka strain (SEQ ID NO:30)

Table 5 shows the sequence alignment of the repetitive region R1 (in the direction of from the 5′ end to the 3′ end) of gene 11 of the Dumas strain, the parental Oka strain and the attenuated Oka strain.

Table 6 shows the sequence alignment of the repetitive region R3 (in the direction of from the 5′ end to the 3′ end) of gene 22 of the Dumas strain, the parental Oka strain and the attenuated Oka strain.

Table 7 shows the sequence alignment of the repetitive region R4 (in the direction of from the 5′ end to the 3′ end) of the Dumas strain, the parental Oka strain and the attenuated Oka strain.

As shown in Table 5, the repetitive sequences of whole R1 region of all three strains, namely the attenuated Oka strain, the parental Oka strain and the Dumas strain, are different from each other. Similarly, the repetitive sequences of whole R4 region of all three strains, namely the attenuated Oka strain, the parental Oka strain and the Dumas strain, are different from each other. Therefore, the repetitive sequence abbabba′bbb′abababx (SEQ ID NO:23) of R1 region (wherein, a represents a nucleotide sequence of GGACGCGATCGACGACGA (SEQ ID NO:19); a′ represents a nucleotide sequence of GGACGCGATTGACGACGA (SEQ ID NO:20); b represents a nucleotide sequence of GGGAGAGGCGGAGGA (SEQ ID NO:21); b′ represents a nucleotide sequence of GGACGCGGCGGAGGA (SEQ ID NO:22); and x represents a nucleotide sequence of GGA) and the repetitive sequence aaaaaaaaaaaax (SEQ ID NO:26) of R4 region (wherein, a represents a nucleotide sequence of CCCCGCCGATGGGGAGGGGGCGCGGTA (SEQ ID NO:24); and x represents a nucleotide sequence of CCCCGCCGATG (SEQ ID NO:25)) are unique to the attenuated varicella virus, and these sequences are useful for the quality control of an attenuated varicella live vaccine.

With respect to the sequences of the repetitive region R3 of gene 22 which are shown in Table 6, the sequences were diverse among the clones of the attenuated Oka strain and the parental Oka strain. Therefore, no unique sequence was found in the attenuated Oka strain.

TABLE 5
R1 region (gene 11)
(SEQ ID NO:23)
Attenuated Oka strain abbabba′bbb′abababx
(SEQ ID NO:31)
Parental Oka strain   abbabba′bbb′ababx
(SEQ ID NO:32)
Dumas strain          abbabba′bba′bbbbabb′abx
a: GGACGCGATCGACGACGA (SEQ ID NO:19)
a′: GGACGCGATTGACGACGA (SEQ ID NO:20)
b: GGGAGAGGCGGAGGA (SEQ ID NO:21)
b′: GGACGCGGCGGAGGA (SEQ ID NO:22)
x: GGA

TABLE 6
R3 region (gene 22)
Attenuated Oka strain
clone 1	b′b′ab′b′ab′b′ab′ab′ab′ax	(SEQ ID NO:33)
clone 2	b′b′ab′aab′ab′ax	(SEQ ID NO:34)
clone 3	b′b′ab′aab′ab′ax	(SEQ ID NO:34)
clone 4	b′b′ab′aab′ab′ax	(SEQ ID NO:34)
clone 5	b′b′ab′ab′b′ab′ax	(SEQ ID NO:35)
clone 6	b′b′ab′aab′ax	(SEQ ID NO:36)
clone 7	b′b′ab′ax	(SEQ ID NO:37)
clone 8	b′b′ab′ax	(SEQ ID NO:37)
clone 9	b′b′ax	(SEQ ID NO:38)
clone 10	b′b′ax	(SEQ ID NO:38)
Parental Oka strain
clone 1	b′b′ab′aab′ab′ax	(SEQ ID NO:34)
clone 2	b′b′ab′aab′ax	(SEQ ID NO:36)
clone 3	b′b′ab′ab′ax	(SEQ ID NO:39)
clone 4	b′b′ab′ax	(SEQ ID NO:37)
clone 5	b′b′ab′ax	(SEQ ID NO:37)
clone 6	b′b′ab′ax	(SEQ ID NO:37)
clone 7	b′b′ab′ax	(SEQ ID NO:37)
clone 8	b′b′ax	(SEQ ID NO:38)
clone 9	b′b′ax	(SEQ ID NO:38)
	Dumas strain aaaaabax	(SEQ ID NO:33)
	a: GCCCGCGCA
	b: GACCGTCCA
	b′: GCCCGTCCA
	x: GGA

TABLE 7
R4 region (noncoding region)
Attenuated Oka strain	aaaaaaaaaaaax	(SEQ ID NO:26)
Parental Oka strain	aaaaaaaaaaax	(SEQ ID NO:41)
Dumas strain	aaaaax	(SEQ ID NO:42)
a: CCCCGCCGATGGGGAGGGGGCGCGGTA (SEQ ID NO:24)
x: CCCCGCCGATG (SEQ ID NO:25)

Example 2

The genomic DNA of each of the attenuated Oka strain, the parental Oka strain and the Kawaguchi strain (wild-type strain of a varicella virus) was individually prepared in the same manner as in Example 1.

Using the PCR primers 01-N12 (SEQ ID NO:5) and 01-R13 (SEQ ID NO:6) shown in Table 8, a region corresponding to a part of gene 6 (a region corresponding to the 5,372nd to 6,134th nucleotides of the Dumas strain) was amplified by PCR, thereby obtaining a PCR product. The obtained PCR product (763 bp) was digested with the restriction enzyme Alu I to thereby cleave the DNA into fragments, and the restriction-fragment pattern was determined by an RFLP analysis. Specifically, each of the PCR products of the attenuated Oka strain, the parental Oka strain and the Kawaguchi strain was digested with the restriction enzyme Alu I, thereby obtaining a DNA fragment mixture, and the obtained DNA fragment mixture was applied to 4.0% (w/v) agarose gel electrophoresis to determine the size of each DNA fragment.

Two fragments individually having a size of 170 bp and 593 bp were detected for the attenuated Oka strain. On the other hand, three fragments individually having a size of 170 bp, 205 bp and 388 bp were detected for the parental Oka strain and the Kawaguchi strain. These results show that the parental Oka strain and the Kawaguchi strain have the Alu I site located between the 205 bp fragment and the 388 bp fragment, but the attenuated Oka strain does not have this restriction site. It was confirmed from these results that the mutation of the 5,745th nucleotide A in gene 6 can be confirmed by detecting the absence of the Alu I site.

Example 3

54 epidemic varicella strains derived from the varicella patients and the zoster patients were individually subjected to an RFLP analysis. Specifically, the difference in a restriction-fragment pattern obtained by digesting a PCR product with the restriction enzyme Alu I was determined by an RFLP analysis in the same manner as in Example 2. As a result, it was found that the PCR products of all epidemic strains were cleaved into three fragments individually having a size of 170 bp, 205 bp and 388 bp. Such a restriction-fragment pattern was the same as that of the parental Oka strain obtained in Example 2 above.

Example 4

The primers shown in Table 8 (SEQ ID NOs: 3 to 6 and 9 to 18) and the restriction enzymes Nla III, Alu I, Bst X I, Sfa N I, Acc II, Sac II, Sma I, a combination of Bss H II and Nae I, or Bsr I were used to conduct an RFLP analysis in the same manner as in Example 2. Specifically, the genomic DNAs of each of the attenuated Oka strain, the parental Oka strain and the Kawaguchi strain were individually prepared in the same manner as in Example 1. Next, a specific region of the genomic DNA was amplified using the PCR primers shown in Table 8 in a specific combination shown in Table 9. The resultant PCR product was digested with a restriction enzyme and applied to an agarose gel electrophoresis. The results are shown in FIG. 2 . In addition, the restriction enzymes used for the RFLP analysis and the sizes of the restriction fragments are summarized in Table 9.

As is shown in FIG. 2 and Table 9, it became apparent that the numbers and sizes of the fragments resulting from the digestion of a PCR product of the attenuated Oka strain were different from those of the parental Oka strain and the Kawaguchi strain under all of the specific conditions employed for the RFLP analyses. Therefore, with respect to the 560th C, the 5,745th G, the 94,167th C, the 105;356th C (the 124,541st G), the 105,544th G (the 124,353rd C), the 105,705th C (the 124,192nd G), the 106,262nd C (the 123,635th G), the 107,136th C (the 122,761st G), the 107,252nd C (the 122,645th G), and the 108,111st C (the 121,786th G), the nucleotide mutations can be confirmed by an RFLP analysis without determining the nucleotide sequence of the genome.

TABLE 8
	Nucleotide
Primer	sequence	Nucleotide No.
01-N01	5′-TCGTTTACTGCTC	158-172
	GGATGGCGACCG-3′
01-R02	5′-GTGTTTATGTATC	849-825
	AGCATACAGAGC-3′
01-N12	5′-ATTGTATGCATGC	5372-5396
	GATTGCTATCGC-3′
01-R13	5′-GGTCTTCCACTTT	6134-6110
	AAAGGGGTTTGC-3′
10-N29A	5′-GAATCATTAGTAT	26025-26049
	ATATTTTTCTGC-3′
10-R30	5′-TGTTCAGAGGGGA	26165-26141
	TGAATCGTTGCG-3′
50-N15	5′-CGATCACGTCGCT	93685-93709
	CACATCCAACCC-3′
50-R17	5′-ATGGCAGAAGAAA	64457-64433
	CACGTATTGCCG-3′
60-N06	5′-GAGGACAACAGCT	105277-105301	124620-124596
	CCACCTTGACCG-3′
60-R06	5′-GAGTAATGTGGCC	105613-105589	124284-124308
	GCCCGGTTTTGG-3′
60-N26	5′-CCAAAACCGGGCG	105589-105613	124308-124284
	GCCACATTACTC-3′
60-R28	5′-ATTACTGTCGACC	106380-106356	123517-123541
	CGAGACCTGGCC-3′
G62-N04	5′-GATCAAAGCTTAG	106736-106753	123161-123144
	CGCAG-3′
G62-R04	5′-CCTATAGCATGGC	107499-107482	122398-122415
	TCCAG-3′
60-N11	5′-AAGGGCTTCCGTC	107729-107753	122168-122144
	GGGCATCATGAG-3′
60-R12	5′-TCGGGTAAAAAGC	108497-108473	121400-121424
	CGGGCGATGAGC-3′

TABLE 9
	Amplified frag-			Detected	Size of restriction
	mentary region	Restriction	Restriction site	mutation	fragment
PCR primer	(nucleotide no.)	enzyme	(nucleotide no.)	(nucleotide no.)	(bp)
01-N01	158-849	Nla III	560		560	V 692
01-R02						W 402 + 290
01-N12	5372-6134	Alu I	5542		5745	V 170 + 593
01-R13			5747			W 170 + 205 + 388
10-N29R	26025-26165	Mae II	26125		26125	V 100 + 6 + 35
10-R30			26131			W 106 + 35
50-N15	93685-94457	Bst X I	94172		94167	V 487 + 286
50-R17						W 773
60-N06	105277-105613	Sfa N I	105347	124550	105356	V 337
60-R06	124284-124620				124541	W 70 + 267
		Acc II	105422	124475	105544	V 145 + 123 + 39 + 30
			105545	124352	124353	W 145 + 162 + 30
			105584	124313
60-N26	105589-106380	Sac II	105707	124190	105705	V 118 + 338 + 336
60-R28	123517-124308		106045	123852	124192	W 456 + 336
		Sma I	106072	123825	106262	V 483 + 79 + 112 + 118
			106151	123746	123635	W 483 + 79 + 230
			106263	123634
G62-N04	106736-107499	Bss H II	107136	122761	107136	V 400 + 117 + 247
G62-R04	122398-123161				122761	W 764
		Nae I	107252	122645	107252
					122645
60-N11	107729-108497	Bsr I	108113	121784	108111	V 769
60-R12	121400-122168				121786	W 384 + 385
V: Attenuated Oka strain
W: Wild-type strain (Virulent strain)

INDUSTRIAL APPLICABILITY

According to the method for quality control of the present invention, it has become possible to conduct an exact quality control and quality assurance of an attenuated varicella live vaccines, particularly with respect to the safety, effectiveness and uniformity of the vaccine. Further, the present invention provides exact and advantageous techniques which can be used for research in the field of epidemiology of varicella and zoster, including a tracing of the effects of vaccination, and these techniques may expedite and enhance the research. Consequently, the present invention provides an exact and very effective measure for preventing varicella and zoster, which contributes to the health of human beings.

#             SEQUENCE LISTING
<160> NUMBER OF SEQ ID NOS: 42
<210> SEQ ID NO 1
<211> LENGTH: 124884
<212> TYPE: DNA
<213> ORGANISM: Varicella virus
<220> FEATURE:
<221> NAME/KEY: misc_feature
<222> LOCATION: (1)..(124884)
<223> OTHER INFORMATION: Dumas Strain
<400> SEQUENCE: 1
aggccagccc tctcgcggcc ccctcgagag agaaaaaaaa aagcgacccc ac
#ctccccgc     60
gcgtttgcgg ggcgaccatc gggggggatg ggattttttg ccgggaaacc cc
#cccccgcc    120
agcctttaac aaaacccgcg ccttttgcgt ccacccctcg tttactgctc gg
#atggcgac    180
cgtgcactac tcccgccgac ctgggacccc gccggtcacc ctcacgtcgt cc
#cccagcat    240
ggatgacgtt gcgaccccca tcccctacct acccacatac gccgaggccg tg
#gcagacgc    300
gcccccccct tacagaagcc gcgagagtct ggtgttctcc ccgcctcttt tt
#cctcacgt    360
ggagaatggc accacccaac agtcttacga ttgcctagac tgcgcttatg at
#ggaatcca    420
cagacttcag ctggcttttc taagaattcg caaatgctgt gtaccggctt tt
#ttaattct    480
ttttggtatt ctcaccctta ctgctgtcgt ggtcgccatt gttgccgttt tt
#cccgagga    540
acctcccaac tcaactacat gaaactactg tccggaaggg gaaggtattt at
#tctcgctt    600
gcagcttgtc gcgcgtgtat gcacaacaaa agctatatat gtcaccaaag cc
#aacgtcgc    660
catctggagt actacaccca gtacgttgca taacctgtcc atttgcattt tc
#agttgcgc    720
ggacgccttt ctccgggatc gtggccttgg gacatcaacc agtggaataa ga
#accgccgg    780
tggtcttgtt tgaacgacga gtggcgacgc gttgttctgc ataagctctg ta
#tgctgata    840
cataaacaca gagtctgtat cgctatcaga ttcccgaaca ccttccggta cc
#ccatactc    900
cgataccctg gacattgcgg atcccaaaaa tataatatta acaggatttg ct
#tatacttt    960
gctacagctt atataaattt atgtgcgata catcttaagt gcatccgtac gt
#tatttata   1020
cattgcctgt cacgtgaaaa gactgtgtta cccaataaag gttctacaaa aa
#atgcttta   1080
ttgggtgttt gtttaatagc tattatcgta acccaccccc gtaaaatcat aa
#aatgcatg   1140
taatttctga gacacttgca tatgggcatg ttcccgcatt tattatgggc tc
#cactctgg   1200
tgcgtcccag tttaaacgcc accgccgagg aaaatcccgc gtcagaaacg cg
#atgtttat   1260
tacgagtgct tgcggggaga actgtagacc tgccaggcgg aggaacgtta ca
#cattacct   1320
gtaccaaaac ctatgtaatt attggcaaat atagcaaacc cggcgaacgt ct
#tagccttg   1380
cccgtctaat agggcgtgca atgacgcctg gaggtgcaag gacatttatt at
#tttggcga   1440
tgaaggaaaa gcgatccaca acgcttgggt atgaatgtgg tacgggcttg ca
#tttactgg   1500
ctccatctat gggtacattt ctccgcacac acggtttaag taacagagat ct
#ctgtttat   1560
ggcggggtaa tatttatgat atgcatatgc aacgtcttat gttttgggag aa
#tatcgcgc   1620
aaaataccac tgaaacacct tgtataacgt cgacgttaac atgcaacttg ac
#agaagact   1680
ctggtgaagc cgcacttacc acgtcagacc gacccactct cccaacccta ac
#agcccaag   1740
gaagaccaac agtttccaac attcgtggaa tattgaaagg atccccccgt ca
#acagccgg   1800
tctgtcaccg ggttagattt gccgaaccta cggagggcgt attgatgtaa tc
#actaaata   1860
aaatacacct tttttcgatt gtacgtattt ttatttaaat gtgtagttca ta
#gtccgccg   1920
acagccgctc gggcttttcc cccacataca acatgatcgt atgcctcgga tg
#caccggtc   1980
caacactccg ccgagaaggg ggatttacaa tgacagtgat acccaatagc cg
#ccagatgt   2040
acacccagct gtccggactc cagcatcatc tgctgagttg cggcgctgaa gg
#gtgcatcg   2100
catagggtgt tataattagc catttccggt aacagtcgtt gggaatttag ga
#ggctgcaa   2160
aacggctgta ggtcaacata cattggggat tcagatggtt tatctcgacg tc
#caagtcca   2220
atcaaaaaag cgtgtaaatc atcagcccgg ccgcatgttg ctcgaagagc ac
#ataacctc   2280
ttaacaccgt acagagggga tggcgtcggt gcatgtgagt tggcagggca tg
#tccacgtt   2340
gtttccaacg ccagtggcgg tataacttgt gtaaacgacg ccaacgggtc ag
#gtttaaga   2400
ttcactcgga tgggttgact gctttcggaa gctcccgttg tatccattaa tt
#aaacgttc   2460
ggtacacgtc tggtgtgtgt tttacccgaa tcagagacgg aattgcaaag at
#attggttt   2520
gaaagcaatg taatcccgcc catatatccc caacgtcgcc ttaaaaactc cc
#acaatatt   2580
acatttttat tagtctttta ttaatataga atcacataaa caattgataa aa
#tcaagggg   2640
tggtgtataa tgattaaaaa tataaattga tatgttttac aagcatgaaa ta
#ggtattta   2700
ctattctaac aggtaaatat gcttaatgat taaaaataca aattagtatg tt
#ttgacaag   2760
catgaaaaag gtatttttta ttttagcagt taaaggtact acacttaaaa ta
#tttaccgt   2820
atggacgggc gtcagaaaga tgcccggccc aagttgagag ggtacattca ac
#acgaccac   2880
actcgcgttg gtgggtgatt agggcctcta aaacaccggc cagacatgac cc
#gggtgtat   2940
attcttgtaa cacttgaacg ttacaactga tatcatcata ttccacaaat tt
#agagccac   3000
ggacaactat attagcaatg cgggcaatca taacaaacat ataagtagta at
#acacgtga   3060
tatcactaaa acgttgctgg cgcaacagtt cggggagagt acgagacccc aa
#atcgttgt   3120
ccctgtttag aagaagacat cttacaaaag gccccagctt taactttaaa tt
#ctccaaaa   3180
gtgacttcga ggttgcaaca atgggattat ttgtgtagat gggcaagttt tt
#tgccgcta   3240
acattttaat ccacgttaac agttcatccg cagactccaa cgcttcaatc aa
#agattctc   3300
cacgtatgac tctctcacgc aacgcgcggg caatacgtga gtccatttta ta
#tgactcaa   3360
aggtacgata aagttcatgt ccgtacaaca tcaactccgg ccaagatgtg tt
#ttgtttta   3420
tccccggaaa acatccaccg gaagcccatg aatcaccctc ttgtattgtg gc
#atatcgga   3480
ctaccagttt ttcaattgtt tcatctaaat ggcgtaccga gtcaatggtc ac
#gctggctc   3540
ccgcggtgga gacgacttca atagcacggc ccgtaattcg atcgaccggg at
#atcatact   3600
cttttcgaat acgctctcgg cgggcgtctc tcttggaaaa tcgcaacctg ta
#cgattcgt   3660
catgtgtctg atcatttctt tctcccgtgg tcattgcagg aggcgttgta gg
#acgccgtc   3720
ttcgatttga cagggatcga tcacggtgtt ttcttgaact ttgagtgtta ta
#agatctgg   3780
atgatcgtcg atgtccccgt tcgatgcgtg catatccagt ctccacgtct ct
#tcctccat   3840
gatggtttga atcgggtaat acaacaacca aagttttcgg gcgattgtgg tg
#gtagcttt   3900
cacgccttcc gtgccttcgt ttggaatacc gtggattata tgctgtatct gc
#agtacgct   3960
ccacatacac agttctagac gttgtggagt cctcgcctgg agtggagcca at
#agcttcat   4020
catttgccca atcggtgact tccaatgcaa agtcatccga aggttcgtct gg
#tagcaaat   4080
tcataaagtc ttcacaaata gtagacacgt ctgggtcggt tggaattgaa gc
#agaggcca   4140
tggctgcaaa atatctgaca attgcgtgtt tgcagttgcc tgtatcttcc gc
#caatgttg   4200
tagaatttat aggctcaccc aaccccgcaa tgggcgtgtt tagtcacatg at
#taatgctt   4260
ctgggagttt tcactttccc caaacaagct tacctgcacc ctttgttcgt aa
#tgcataaa   4320
aataaccact gctatagcaa atatgacgat ataaaaacat tttatagcaa gg
#ccggacat   4380
tactgtagcg caacatgttg tgcatatacc acgtattccc cccgtattga ta
#tgatttaa   4440
atgattatcc ttggttggtt ttggtctaac ataagatata agctctacta ta
#gcgagcgt   4500
gcatacaaca acccaggcca gaatccgaat gtatgtgggg tataataacg cg
#catggtgt   4560
atatgcaacg ccaagcgtta aaagcacaat acatccagat gatatatgag cg
#ataacctc   4620
caaaagcatc aataacgtaa cacctttatg catatataaa aaacttatag gg
#tcagcatt   4680
aaatacttta ctcataccat cccgtcgcat ggaaacatca cataacaacc tt
#gccaactt   4740
tgtatatggg taaccaagaa gaatgttcga aataacccgt gttacgtaat tc
#agtgaata   4800
tgatgtgggg gatattaact cacaggatga tcggaatggc ccaaacatac ga
#cgtattcg   4860
tcgaaattgt aaatacatac catatacaaa ccatgcaaaa aaaatcattt tt
#agctgcac   4920
gcaccaaaaa taagcgtgac aattacgtgt tcccagaaca attcgaattt tg
#tcatgcaa   4980
aggtgtagaa atagcggttt ttaccatagt atctcctgat aatagatttt cc
#cggcagct   5040
gtaatcgtat ccagataggc catccaaaaa cgttgagtgg tttacaaacg tt
#acatatat   5100
aagagagttg ttataagacc cccatacaac cggtccacca ttaatcaccg tg
#gttgcata   5160
cacacactca tgttcaaact ttacacgagc ggtataccat agggtaaaaa ca
#gcatgtcc   5220
gctaagtaga cacataatta taaaatgttc tgtcttgatt cctaaagcct gc
#atgacccg   5280
tggaagatgg caattcaagc acgatgtagt atcacacggt tggtgttaac tc
#gaagttaa   5340
atttggataa ttaggtactt ctagagtaaa gattgtatgc atgcgattgc ta
#tcgcactt   5400
tgtagcaaaa cattgttgtg caagcgaaat acacaaacgg ttgtgatgat cc
#actcgcag   5460
agacacaaat gtccggggag ccgttcttcc tccgcgatgg ggatatcgaa ga
#caagtgaa   5520
cccttttgtt ccgcatatga gctgaaataa cacccagtcc cttttgatgg cg
#atacactt   5580
tgatgatgtt aaggtatatt cgcgatcacg cccggggaaa tgaacagcaa ta
#tgctccac   5640
aatagattct aatattgtgc tgtcgacaaa ggcctccagt gtaaatgcgt cc
#agacaagt   5700
taccccgcgc tcttttagag cctttgttaa agatatttgc ggggagctaa at
#atttgttt   5760
attacgcgca accttacgtt caaaaaactc tgcgtattcc cccccaaggt ta
#tgtaaaat   5820
aaattgcact ggaacattcg actgcggtct tgaatgaaaa tgaaagtttg cc
#gggtttct   5880
atgtgatgtc acaaacgcta atatatcaat acactgctca ggtacaacat aa
#aatgggag   5940
tagttgtcca accgccgtcc ctgtggttgt tactttggag aaaaaaggca gt
#cttaaact   6000
atgtccgtgg ctataaacac cagtatctat aaacgaaaag tcccgtaaat ac
#ggaccaat   6060
atattcaaca aattcccgtt ccagcaacac cgcttgctgt aatatttgtg ca
#aacccctt   6120
taaagtggaa gaccccacta acgcataggg atttgggatt ggtacgcata cc
#ctgaaacc   6180
tattttctct ttacagttac agggtagagt ttcatgcaag ttttcattgt tt
#gatacatc   6240
ggcgtgtgta tggacttcag acgttgtctg tgtatcaaaa aaccatacat cc
#tctgtata   6300
attctcttct acacacgtgt ataattcgcc attttctatg taaaaatcga tg
#tcagaatg   6360
gctggttata tccaataaat tatcatcatc caacacctca acggtaggtt ca
#ggacatgc   6420
agttttataa aaataacatg ggtctttgtt agggtttacc acggcctttg ga
#aaaagtaa   6480
ttgcatggcc gttaaaatac catgacgaaa tgctcgcatg ccggcatgta aa
#atacccaa   6540
tgggatgggt tttcttatat gaaagtctac atcaagtatg aggtttgtga tt
#ataagatt   6600
tgtattaaat agctcattcc tgtttatata aagctgatct ttgggtatgt tt
#gatgaaat   6660
tttagaaacg tttttaacag acgtagataa tagtaaagtc aactgcatat ct
#cgtagtga   6720
agcggcaaca aaattacatg gattaatttg tttaaggtcc tccgcaatta at
#cgagcctc   6780
gtgcggtaaa gtgtaacggt ttgttattga tgaccacgta tcattagcaa ta
#acagcaaa   6840
tgcttgggcg ccgtgaggca aggctacccg atatacaggc attggtccag tt
#acctcaga   6900
atggccgatg agggcttcta atggagtttt ataactcagg atggatacat ca
#tgtgtggc   6960
tatcccagtg gcagcagaga aaaacagtaa tagttttgta atccccgggc tc
#gtatcaaa   7020
accagtacga ccactttggt taggtgtatc gtttgcaaag ttggctgctc gt
#aacgcctc   7080
cgcggaaaca cccgaatcct caaaattaga caattcgtca aaaccgggtg ga
#tttgaggg   7140
aatagtggag gaccatccat atggactaaa ttgtttttca atgttttcca ca
#cgacgagt   7200
tagcgttgta gctaggtcac atacgcctat aaacttgcta ggttttgcgg ca
#tacgtaag   7260
acttaaagta tatgttttag taattgtata tttatgtcca atctcaggtc ca
#agttcagt   7320
gacatcacaa attacgttct tttttatata gtcacgcatg ttgagacgag aa
#cgtacatg   7380
attaaaaaaa ttagcagtag ctctttttcc caggttggat gattttaaga gg
#accggttt   7440
attcacaaaa tctgagtatg taaccgcttg taggtggtct gcgatctgtt tc
#cgattgaa   7500
acattcaaaa tgtgccagat aaatataatc aacaaattca cggtctggaa ct
#ttaaggcc   7560
ttttctatcg ttggtaatat actccgatac tgcgtgtatt tccgttgtgt ct
#gtatgtat   7620
tcgctgtaaa atgtacgata gagcattttt ggctgtcaaa cctcgtgtat at
#gttgagga   7680
acaacaaaac atggaaagtt tatcaaaaga caacaagtcc gaaatattgt ac
#ccactaca   7740
attaggtaat gccgggactt ggtaagttaa aaacaaatct ttaattgcct gt
#aagtcata   7800
taagggggtt tccaacgtat tgtaacttgt gtccgtttgt aacaagtaat ag
#cgtgtagc   7860
caacactagc gttttttcag agggtccaaa tcgaacaata taccaaaacg gc
#gagcatcc   7920
atacccccag tagagtcgtc gatatgcagc caatacttga cgttcgtaat gg
#gcatataa   7980
tgatgttagc tcctgacgac caacggattt tttaactaac ttgcagagtg tt
#gcctctgt   8040
gatgcatagg ccgttgtccg ataatccctt tcggtttaaa tggtgtgttg tt
#accatcag   8100
agtttgtata acttccgagt gaatgtcaaa cgtctccgat atacataggg ta
#tcagatat   8160
tatatgcgga tttaggggtg ctccatacca taacgcctta tataaagctt ta
#aaatcagt   8220
ttgggtttta aaacaacaaa aaaatatagg ccagacccgg gatcgtacat ct
#ccagttga   8280
aaatccacca attaaataaa aaataacgtt gacgtcccta ctacaaaata aa
#tgcattat   8340
ttggttttct tcatcgtttt cagttacttc acgtgggcgt ttagttggga tt
#acttgcgt   8400
gatctcttcc ctcccatttt tgacaaagac gtcatctaag tcgggagtcc aa
#gtataact   8460
caccacatac agaggttctg tgcttatctg cccggtaagc aacaacagcg ag
#tgggagat   8520
tgcacatccc tttgtggcaa ataataaccg aatcgtcggt ttggaggatt ta
#tccatagt   8580
tcaatacgtt ggaaagccag tcaatcatgc agacggtgtg tgccagctta tg
#tggatatg   8640
ctcgaatacc aactgaagag ccatcttatg aagaggtgcg tgtaaacacg ca
#cccccaag   8700
gagccgccct gctccgcctc caagaggctt taaccgctgt gaatggatta tt
#gcctgcac   8760
ctctaacgtt agaagacgta gtcgcttctg cagataatac ccgtcgtttg gt
#ccgcgccc   8820
aggctttggc gcgaacttac gctgcatgtt ctcgtaacat tgaatgttta aa
#acagcacc   8880
attttactga agataacccc ggtcttaacg ccgtggtccg ttcacacatg ga
#aaactcaa   8940
aacggcttgc tgatatgtgt ttagctgcaa ttacccattt gtatttatcg gt
#tggcgcgg   9000
tggatgttac tacggatgat attgtcgatc aaaccctgag aatgaccgct ga
#aagtgaag   9060
tggtcatgtc tgatgttgtt cttttggaga aaactcttgg ggtcgttgct aa
#acctcagg   9120
catcgtttga tgtttcccac aaccatgaat tatctatagc taaaggggaa aa
#tgtgggtt   9180
taaaaacatc acctattaaa tcggaggcga cacaattatc tgaaattaaa cc
#cccactta   9240
tagaagtatc ggataataac acatctaacc taacaaaaaa aacgtatccg ac
#agaaactc   9300
ttcagcccgt gttgacccca aaacagacgc aagatgtaca acgcacaacc cc
#cgcgatca   9360
agaaatccca tgttatgctt gtataaatat tgaaataaaa actaaaaacg tt
#tctggtgt   9420
atgtttttat tttgtatata aaattaaaac attgctggct ggcgtggtta tt
#acatttaa   9480
tgttttagta gaaaatcgac atcgtttgtt tctttatcag ttgaaccaaa tc
#cacgcgtt   9540
ccccgttcgc tgggtgtggc tattagatct aacgttttag taaaatacca tt
#gtacaccc   9600
ggtatgccac atttaccgcg gatagcataa ggaaatgcaa tattacttaa aa
#cgttgtgt   9660
tttaagtgta tttgggtgtt gtgatctatt aacaggacct gtgcaagacg at
#ctcccgtt   9720
tttatacgta tgtcatcacc cgtgagatta tatacgtaga atttacagtg tt
#ctcctgca   9780
ggccatgccg ttggacacac gataatgcct gatcggcttt tcgatgatct tc
#caaaaata   9840
taagcgttta tactcggatg ttgtaagtcc cagtctctta taatcggtaa ga
#caattttt   9900
ataaattcat tcctttttaa atataggtta tatggtacac aaatatcata tc
#ccgcgtct   9960
tcttggcgtt ttggattgat gatatgtttg taggttaagg gaacatcgat at
#ggtattct  10020
gcagaatccc tatgtaaagg ttgcccctgc tgtaccgtgg aaatatcagc aa
#attcaggt  10080
ataacgggtt tttcataatt tgacggcgag tttgataagg gttgaacttg ta
#tcgattta  10140
aaaattggat ccagatgttt aagaacgttt tttgggagaa ggcgactttg tc
#ttaatttt  10200
accgggaaca agtagattgt taaatgtccg ggtaaaataa cggttactcc tg
#gccggtaa  10260
tacaaaaggg ctgaaattac tcctctgtaa cccgcatcaa taactccgtt gg
#cgacaaaa  10320
aaattgtctt catcagcaag ggcagtatct ttgcattgaa ttaacaacag tg
#cgtattca  10380
ttgggaggcg ccgacttaac caacagctcc aactgctgca tataaaaacc gc
#cccgtgtt  10440
acagattttt cagatggcag ttcgagtttc ttgtggttcc ggagtaacaa cg
#gttgatgt  10500
cgacttactt tatcgtctaa cacgcattgc agcgtatctg cacattcagg tt
#gaacttct  10560
attaaaattg tatcttttaa acaccgattc ggaatagttt ggctacaaaa ca
#tatcacct  10620
gtatttactg ccgtttccaa gatgggatca attaccgctt cgttcatatt aa
#taacgatg  10680
caaattttat ttttttgtga agacagcagt ggggagccaa actttgcaga ac
#ggaatttt  10740
tggcatgcca gctgttcggc tcgtggagtt tatatcgacg gatcaatgat ca
#ccaccctt  10800
ttcttctacg catccctttt gggggtgtgt gtagccctta tttcgttagc tt
#atcatgcg  10860
tgtttccggt tatttactcg ttctgtatta cgcagcacgt ggtaaacccg tt
#tgcctata  10920
aaaggggcag gcgtgtataa gagggcccct gtttaatacg cggtctgccg tg
#tttggata  10980
tttcacgacc ctatcgttta tttacgtaat ggcatcttcc gacggtgaca ga
#ctttgtcg  11040
ctctaatgca gtgcgtcgta aaacaacgcc tagttattcc ggacaatatc ga
#accgcgcg  11100
gcgaagtgtg gtcgtaggac cccccgatga ttcagacgac tcgttgggtt ac
#attaccac  11160
agttggggcc gattctcctt ctccagtgta cgcggatctt tattttgaac at
#aaaaatac  11220
gacccctcgc gtacatcaac caaacgactc cagcggatcg gaagatgact tt
#gaagacat  11280
cgatgaagta gtggccgcct ttcgggaggc ccgtttgaga catgaactgg tt
#gaagatgc  11340
tgtatatgaa aacccgctaa gtgtagaaaa accatctaga tcttttacta aa
#aatgcggc  11400
ggttaaacct aaattagagg attcaccgaa gcgagctccc ccgggagcag gc
#gcaattgc  11460
cagcgggaga ccaatttcct tcagcactgc accaaaaacc gcaacaagct cg
#tggtgcgg  11520
tcctacgcca tcatataaca aacgcgtctt ttgtgaagcg gtccggcgcg ta
#gccgccat  11580
gcaggcacaa aaggctgccg aagcggcttg gaatagtaat cccccaagga at
#aacgccga  11640
attagaccgt ttgttaaccg gagccgttat tcgtattacg gtgcatgagg gt
#ttaaattt  11700
aatacaagcc gctaatgaag cagacctagg tgaaggagca tcggtatcca aa
#cgtggaca  11760
taatcgaaaa actggagatt tacagggggg catgggtaat gaacctatgt ac
#gcacaagt  11820
tcgtaagcca aaaagtcgaa cggatacaca aacgactggg cgtataacta at
#cgaagtag  11880
ggcccgttct gcatcaagaa ctgatacgcg aaaataggga tataattacg ca
#gtaacggt  11940
ttacccggta ttatgtataa taaataaacg tataaaagac agtcgtggtt tg
#tgtttatt  12000
ataaatgtgt attatatgtc acatattata aactgtttaa atagtaccac gt
#ggtattat  12060
gaacagttta taatcagttg ctaccaaaca aaccccatta gacggcgggt tt
#tgataaag  12120
ggaatcgctt atttaaacta aagattttac tctataagta tggagtgtaa tt
#taggaacc  12180
gaacatccta gtacagatac gtggaatcgt agtaaaacgg aacaagcggt tg
#tggacgca  12240
tttgatgaat cgttgtttgg tgatgtagca tcggatattg gatttgaaac gt
#cgttatat  12300
tcacatgcag ttaaaactgc tccgtctccg ccttgggtag ctagccctaa aa
#ttttatat  12360
caacagttaa tacgggatct tgatttttca gaagggccgc gtttactatc at
#gtcttgaa  12420
acctggaacg aggatttatt ctcatgtttt cctattaatg aggacctata tt
#ccgatatg  12480
atggttttat ccccggatcc agatgacgtt atctcaaccg tttcaaccaa ag
#accatgtt  12540
gaaatgttta atttaacaac ccggggttcc gttcgattgc ctagtccacc aa
#agcaaccg  12600
acggggcttc cagcttacgt tcaggaggtc caggattcgt ttaccgtaga ac
#tacgcgcc  12660
cgggaagaag catacacaaa actactagtt acttattgta aatcgattat ac
#gttatctc  12720
caaggaacgg cgaaaaggac gacaataggt cttaatatac aaaaccctga cc
#agaaagct  12780
tacacgcaac tcaggcaaag tattctactt agatattatc gtgaggtggc aa
#gtttggcg  12840
cgtcttctgt acctacattt atatttaacc gtaacgcgtg aattttcctg gc
#gtttgtac  12900
gccagtcaat ctgcacaccc ggacgtgttt gcggctttaa aattcacctg ga
#ccgaacgt  12960
cgacagttca cgtgtgcgtt tcatcctgta ttatgcaacc acggcattgt gt
#tattagaa  13020
gggaaaccac taacagcgtc tgccttgagg gaaataaatt accgccgccg ag
#aactggga  13080
ctgcctctag ttagatgtgg tcttgttgaa gaaaacaaat ctccgttggt tc
#aacaaccc  13140
tcattttcgg ttcatttacc acggtcggtg ggttttctta cccaccacat ta
#agcgtaag  13200
ttagacgcat atgcggtcaa acatcctcaa gaaccgagac atgtacgagc gg
#atcatcct  13260
tacgcaaaag ttgttgaaaa tagaaactac ggtagtagca tcgaagctat ga
#ttttagca  13320
cctccgtccc catccgagat cctgccgggg gacccaccac gcccacccac gt
#gtgggttt  13380
ttaacgcgtt aaacgtcatt ggggtagagg gtgtaaataa attacgaaaa cg
#tgcatgcg  13440
ttttttattt ttacaatgcg ccgtatatgg tatgtctgtc atgtgctcta aa
#gtcccata  13500
tataaaagaa gccccaacga gtgtatgcgt attgcgtacc gcgaccctgg ga
#tgttttac  13560
aggcgcgttt gtttgtctcg gttataagta tgcagtcggg tcattataac cg
#gaggcaat  13620
cccgccgaca gcggatatcg tctaatacca cagactcccc ccgtcacaca ca
#cggaacac  13680
gttatcggtc aaccaattgg tatacacacc caccccagat attgtccaat tc
#agaaacat  13740
tagttgcggt tcaagaacta ctgaactccg agatggatca ggacagcagt tc
#tgacgcat  13800
cggatgattt tccgggatac gccttacatc attctacata taatggatcc ga
#acaaaata  13860
catcaacttc cagacatgaa aatcgcatat ttaaattaac ggagagggaa gc
#taatgagg  13920
aaatcaacat caatacggac gcgatcgacg acgagggaga ggcggaggag gg
#agaggcgg  13980
aggaggacgc gatcgacgac gagggagagg cggaggaggg agaggcggag ga
#ggacgcga  14040
ttgacgacga gggagaggcg gaggagggag aggcggagga ggacgcgatt ga
#cgacgagg  14100
gagaggcgga ggagggagag gcggaggagg gagaggcgga ggagggagag gc
#ggaggagg  14160
acgcgatcga cgacgaggga gaggcggagg aggacgcggc ggaggaggac gc
#gatcgacg  14220
acgagggaga ggcggaggag gattattttt ctgtaagtca agtttgcagt cg
#agacgcgg  14280
atgaggttta ttttacgtta gacccggaaa taagttacag taccgatctt cg
#cattgcaa  14340
aggttatgga gcctgcggta tcaaaggaac ttaatgtatc aaaacgttgt gt
#tgaacctg  14400
ttaccctaac aggctctatg ttagcgcata atgggtttga tgagtcctgg tt
#tgctatgc  14460
gcgaatgtac ccgtcgcgaa tatattacgg tccaaggatt atacgaccca at
#tcatttac  14520
ggtatcagtt tgatacttcc cggatgacac ccccacagat tttgagaact at
#accagccc  14580
ttcctaacat gacacttggt gaacttttat tgatttttcc tattgaattt at
#ggcccagc  14640
caatttctat agaacgtatt ttagttgaag atgtattttt agataggcgg gc
#ttccagta  14700
aaacacataa atacggcccg cgttggaatt ccgtctacgc acttccatat aa
#tgcgggta  14760
aaatgtatgt acaacacatt cctgggtttt atgacgtgtc cttacgtgct gt
#gggccaag  14820
gaacggccat ttggcatcac atgatattat ccacagcagc atgcgctatt tc
#taatcgca  14880
tttcacatgg agatggatta ggatttttgt tagacgcggc aattcgtatt ag
#cgcaaact  14940
gtattttttt gggacgtaac gataattttg gcgtggggga tccatgttgg tt
#agaagacc  15000
atcttgccgg attaccacga gaagccgtac ccgacgtact ccaagtgaca ca
#gttggttt  15060
tgccaaatcg gggtccaacg gttgccatta tgcgtggttt ttttggggcg tt
#ggcatatt  15120
ggcccgaact aagaattgct ataagtgaac catctacatc tttggtgcga ta
#tgctaccg  15180
gtcacatgga acttgccgaa tggtttttat tttcacgtac acatagttta aa
#gccacaat  15240
ttaccccaac ggaacgggaa atgttagcgt cattttttac gttgtatgtt ac
#tcttggtg  15300
gaggaatgtt gaactggatc tgtagagcaa ctgcaatgta tttagctgct cc
#ttaccatt  15360
cccgttcggc ttacatcgcg gtctgtgaat ctctgcccta ttactatatc cc
#ggttaata  15420
gtgacctgtt atgtgattta gaggtattac tgttaggcga ggtcgacctc cc
#aactgttt  15480
gtgaatccta cgcaactatt gcacacgaat taaccggata tgaggctgtt cg
#cacagcag  15540
ccacaaattt tatgatagag tttgccgatt gttataagga aagtgagacc ga
#tttaatgg  15600
taagcgcgta cctgggggcc gttttattgt tacaacgggt gttgggtcat gc
#aaatcttc  15660
ttttgttgct tctctccggt gctgcgttgt acggaggatg ttcaatttac at
#cccccgag  15720
gtattttaga tgcatataat actttaatgt tggcagcaag tcctctttac gc
#tcaccaaa  15780
ctttaacatc cttttggaaa gaccgcgatg atgcaatgca aactttgggg at
#tcgaccga  15840
caacggacgt tttacccaaa gagcaagaca ggatagttca ggcatcacct at
#agagatga  15900
acttccgttt tgtgggattg gagaccatct atccccgaga acagcccatt cc
#ctccgtgg  15960
acctagccga aaatcttatg caatacagga atgaaattct gggtttggat tg
#gaaaagcg  16020
tagccatgca tttactacga aaatattaag ggttgtgatt tttttcatta gg
#atgaaaag  16080
aacgtttcct agccacaccc acaaaggagt ttgtaaaata aaatctctgt tt
#agacctta  16140
aaatttgttg tgtgtgttgt gtggggggtc cgtgaggatc gacctttaca ag
#atataatt  16200
tgtccatatc gcaatgtttt ctcggtttgc gcgttccttt tccagcgatg at
#agaacgcg  16260
taaatcttat gatggtagtt accaaagttt taatgccggc gaacgtgatt tg
#cccacacc  16320
tacccgggac tggtgttcta tttcccaacg cataaccagc gagcgcgtga gg
#gatggatg  16380
tcttattcca acgcccggcg aggctttgga gacggcggta aaggctttat ct
#gaaaagac  16440
cgacagccta acatcgccgg ttttacaaag taccgaaaga cacagtgttc tg
#cttggatt  16500
acaccataat aatgttcctg aatcgttggt ggtctcgtgt atgtctaacg at
#gttcatga  16560
cgggtttatg cagcgttata tggaaacaat tcaaagatgt ttggatgacc tg
#aaactttc  16620
tggggatgga ctttggtggg tttatgaaaa tacatattgg cagtatctca aa
#tacaccac  16680
aggagccgag gtaccggtga cttcagagaa ggtaaataaa aagtctaaat cc
#acggtttt  16740
gttgttttca tccgtagttg ccaataaacc aatatccaga catcctttta aa
#tctaaagt  16800
tataaattcg gattaccggg gaatatgtca ggagctacgt gaggcgttag ga
#gctgtgca  16860
aaagtatatg tattttatgc gtccagatga tcctacaaac cccagcccgg at
#acaagaat  16920
acgtgtacaa gaaattgcgg cttacacggc tactggctac gggtggatgt ta
#tggttctt  16980
ggacgttgtg gacgccaggg tatgtcgcca tctcaaactt caatttcgac gg
#attcgagg  17040
gccgcgcgcg tctgttattc cagatgattt gcttagacga catttaaaaa cg
#ggtcctgc  17100
ggtctcagcg ggcacaggag ttgcgtttat tttagcagca acaactgcca gc
#gctcttac  17160
tgcgcttttg cgtattagtg tattatggcg aaaggaagag tggcgggatg gt
#ttaaatgg  17220
aaccgcagct gcaattgttg cggcggttga acttattacg cttttgcacc ac
#cattttca  17280
atacttaatt aatatgatgc ttattggata tgcatgttgg ggggatgggg ga
#ttaaacga  17340
tccttatata ttaaaggcgc tacgtgccca gggacggttt ttatattttg cg
#ggtcagtt  17400
ggtcagaaca atgtcaacac acagttgggt tgtgttagag accagcaccc at
#atgtggtt  17460
ttcccgggcc gtggcgcaga gtattttagc acatgggggt aaacccacaa ag
#tattatgc  17520
tcaggttctt gccgccagta aacggtatac tccgttacat ttaagacgta ta
#tccgaacc  17580
atcgagtgtg tctgatcagc cgtatattcg ttttaatcga ctgggatctc ca
#atagggac  17640
aggtataggg aatttggaat gtgtctgttt aacgggaaat tatttatctg ac
#gacgtaaa  17700
tgcaagttcg catgtaatta atacagaagc accgttaaac agtatagcac cc
#gatacaaa  17760
tagacagcgg acttctcgcg ttttagttcg tccagacacg ggtttggatg ta
#actgtccg  17820
aaaaaaccac tgtctggaca taggccatac ggacggtagt ccagttgacc ca
#acgtatcc  17880
tgatcattac acccggataa aggcggaata tgaaggtccg gttcgggatg aa
#tcaaacac  17940
aatgtttgac caaagatcgg atttacgtca catagaaacc caagcatctt ta
#aatgatca  18000
cgtatatgaa aatataccac ccaaggaagt gggttttaac tcatcttcag ac
#ctggatgt  18060
ggatagcctt aacgggtaca cctccggaga catgcataca gacgatgact ta
#tcaccaga  18120
ttttataccc aacgacgttc ccgttagatg taaaaccacg gttacgttta gg
#aaaaatac  18180
gcctaagagt catcattaag tacagcggtt aatagatagt tatggactag gc
#actttggc  18240
ggtcatttcc acaaccaggt taaaattggg ggatttggga gaaaatagtc ta
#ttgcgtat  18300
tttctgttca ataattggac tgcgttattt aaaggtctga ttggttgatt gg
#gttataaa  18360
aggaattact cctttaaatt ttacttaatg tacccacaat atcaagtggt cg
#tttgtatt  18420
taacgattat taccggtacc atgggagact tgtcatgttg gacaaaggtg cc
#gggtttta  18480
cgttaaccgg cgaacttcag tacttaaaac aagtggatga tattttaagg ta
#tggagttc  18540
ggaaacgcga tcgaacagga atcggaacgt tatctttatt tggaatgcaa gc
#tcgataca  18600
atttgcgaaa tgaatttcct cttttaacta caaagcgtgt tttttggagg gc
#cgtcgtgg  18660
aagagttgtt atggtttatc cgcgggtcaa ccgattccaa agaactcgcc gc
#taaagata  18720
tacacatatg ggatatatac ggatcgagca aatttctaaa taggaatggc tt
#ccataaaa  18780
gacacacggg ggaccttggc cccatttacg gcttccagtg gagacatttt gg
#agcggaat  18840
ataaagactg tcaatcaaac tatttacagc aaggaatcga tcagctgcaa ac
#tgttatag  18900
atacaattaa aacaaaccca gaaagccgac gaatgattat atcgtcttgg aa
#tccaaagg  18960
atatcccctt aatggtacta cctccatgtc acacgttatg tcagttttac gt
#tgcaaacg  19020
gtgaattatc ctgccaagta taccagagat cgggggatat gggccttggg gt
#accgttca  19080
acattgctgg atatgcactt cttacctaca tagtagcgca tgttacagga ct
#taaaaccg  19140
gagatttaat tcatacaatg ggggatgcac atatttactt gaatcatata ga
#tgctttaa  19200
aagtgcagct agctcgatcc ccaaaacctt ttccttgcct taaaattatt cg
#aaatgtaa  19260
cagatataaa cgactttaaa tgggacgatt ttcagcttga tggatataat cc
#acaccccc  19320
ccctaaaaat ggaaatggct ctttaatgga tttttaaatg ttgtcaagac ag
#tagatgtg  19380
ttgcgaatgt aataaaatga tatacacaga cgcgtttggt tggtttctgt tt
#atgaacag  19440
caacggatgc atagggttgc gataactgcg ataagaccca atgtcccaag ga
#tagatatc  19500
acaccaatta taactgctac aacggaaaat gtagtggcgt aggtagatgc at
#cgtaggta  19560
taaacggccg aaaacggagg gaatttttta gggtaaccat ctagatgaca cg
#aataggtg  19620
ataggtccgt cgagttccga tgttggacaa gaactttgca tgtttacaaa cc
#gtttgttt  19680
tgatcacaca ccccagtaat ctcactgttt tcgtggttaa tgggagaatc gt
#taacccac  19740
catacgaaat gtacaacgcc acgtggcaca cattttgccg tacatactat gt
#gtccatca  19800
ataataccta tagacacgtt gggaaatgga tagacgtcag gggtaacgac ag
#cagaatat  19860
ttcatattag agacgccatc ccgaatccat aaaacattac attggatggc tg
#ggggtggg  19920
taatccattt gtttttgctg tggaattcgt accgccgaaa cataactaaa ta
#atccattg  19980
gcatattctt gtattgcatc ggttataaaa ttttttccga tgttaccaaa cc
#ttgaagtc  20040
caccgaacac gtaccgagtg cggtggataa tactttgata cgttacagta gg
#ctgcgtat  20100
gtctgtccgg ttaagactgg atcgccgaca acggtaatat ttggacgata at
#acgttgta  20160
actgtaatac tgtgttccga tatgacgttc ttagtttttg tattaacgac tc
#gccaaata  20220
tacgttccct ccgtggtagc atccatagat aaaattgtta cagaaaaatc ag
#acgttgtt  20280
ttaacatctg gtattacata attttcctta gcgtgtgtaa atatctcagg gt
#tgtttatt  20340
aagtttaaat cggcactgtt gctatataac ataaccggta aatctggcat gc
#gtattaac  20400
gcattgccca gttgacggtg cggatctata aggtgacgcg taaaccaaac tt
#caatatga  20460
agatcggggc gtataagcga cttccacctt gttatatttg aaccttccgg at
#ctaaagaa  20520
tattgttcat atgttttttg ttgctgctta aaggccgcct gttgtccggt cg
#ttagacgc  20580
atgtaacaag gcatgataaa tgtgtgaaaa tagggtatgg attgtattcc gc
#cgtgaacg  20640
cattgtatat tttcatatag aaaaggtggt tgtgaatgtt gggtgttggc tg
#cgggatcg  20700
ggctttcggg aagcggccga ggtgggcgcg acggcgggat cgggctttcg gg
#tagcggcc  20760
gaggtgggcg cgacggcggg atcgggcttt cgggaagcgg ccgaggtggg cg
#cgacggcg  20820
ggatcgggct ttcgggtagc ggccgaggtg ggcgcgacgg cgggatcggg ct
#ttcgggaa  20880
gcggccgagg tgggcgcgac ggcgggatcg ggctttcggg aagcggccga gg
#tgggcgcg  20940
acggcgggat cgggctttcg ggaagcggcc gaggtgggcg cgacggcggg at
#cgggcttt  21000
cgggtagcgg ccgaggtata taattcagtt atacttacgg gtgtgggttg ag
#attcagtc  21060
gataattgta tacacgcgat cgttaaaatt aaatttattt gtatccgctt ca
#tcctggtt  21120
tttattgaca catccacgct ccccttaaat aaaagattaa aacacccacc gc
#ggaattta  21180
aatgatggaa acgttttttt cgacattggg aataataaaa acggcttttg ca
#actttaaa  21240
aactttattt atctcgatta cgatacatat gtaccacata gatagcatag at
#ttattata  21300
atataaacac acacgtgata tactttagtg atatgagatg ccataaaaca gt
#caataggt  21360
ttaacgctta gtctcatcat ctgaatacac gtcaaacccg ccgcaactgt tg
#atgttaga  21420
attataatag ctccccatga aatgccggca aatgttacag ctatacccgt ca
#ccgaggtc  21480
gttgtatata atacaattac ccataggttt tttttttctt gatataaaac gg
#caaaaccc  21540
tgtaacccaa atgctataat atgacctcct attgaaactg ctaacgttac tt
#gtgtaagt  21600
ttgataaaat gatttaattt aattatatgt gagattgccc acattaatgg gg
#taactata  21660
tataacaccg ggggtataac agacattata cgaattcctt taaacacgcg tt
#taagggtc  21720
cgggaacttt ctcgatggtc acatactctc ccgcggtcat tttgtgtata ta
#caacggca  21780
aaacctaaat ctgtataagt gtttaattgc ttatggcgat ttttacgata ta
#tacacgta  21840
tcttgcaaat cggtggcggc atcgacaatt gaaactagtg tgacaataga ta
#tacacaat  21900
ccaataagaa cctcatattt actgacatac atatataaaa taacggttag ta
#aacctccc  21960
aacccagttc ccaacatcat aacataaaaa taaatatgcg gtccattgaa tg
#tcgtaaca  22020
aagttgtagt aatggatatg cacagcagcc actgttccgg taatcgcgga ta
#tggaaatt  22080
cccagtaatt ctacaaatgg aagatcccgg gatattgggc aaccaaccgc cc
#ataacaca  22140
gcaaaaccca acacgaccac cgtctgcaaa catcgtccca attttgctaa tg
#tgcgtaga  22200
aatttcacgg atgttggcca taaccccgaa acgacgatca accccataat ag
#ttgcattg  22260
acggcagctt cgcagacgtg atattgtaaa attaacccgg acgtgataac gc
#ttgcttgt  22320
agtcccacga gaaacaaccg cgatgctgag gttattgcac acgaattaca tt
#cttgaggg  22380
tttccgacac atccttggat tgattgagcg cggattaatt ctctgtctaa ca
#cacccagg  22440
ttttcatcat ggacagctct ttcaccattc acggccatgt cttaagttta at
#aattcaaa  22500
acaaataaaa atgtgttcat ctatggtaca cacaagtttg tatgtaaaat at
#aagcaaaa  22560
gttgcactta tttaactgta catattacgt cagattcacg tgataattca ga
#ataatcca  22620
gggttcctgc agggtccact ggaggagcca cacaatattc gcgaattccg at
#tccctcct  22680
gccatgtggt ttcggggagt ttccccccca ttttatttcc ggtatttttt tc
#gtttcttt  22740
ttgttaataa attgcgtctt ttttttaatg gtggttcatc cttcacagat tc
#catgttcg  22800
caaataattg catcgaggtt aatttttctt taaggtcttt gggacttaag aa
#cgttgcat  22860
aaaaaaaaga atgcacgggt gcggaacgtt ggatatacaa tccaaccatg gg
#ggagttag  22920
ttaaggcgag ataaaaatta atataacacg tctcatcccg tgttaactta ag
#attttgta  22980
cggcagaacg gaatccactg tgtgtttcca ataatactcc aaattcacgc at
#actcccgc  23040
tgccataaac aacattatta aggatccttt ttgaatttgt gattgagcgt at
#taaattat  23100
atggtgtagg cttgcttccg tttatatcca aggaaacatt aaatgagata aa
#accacccc  23160
cggcggtctg gatgtacata tccgtggctg ttagaatgaa gcatgttgta aa
#cccaaaag  23220
ttttaagtag tcgctgtaaa cgggtgaatt gatcgcgttt taagcaaatg ct
#tatatctg  23280
gagttagatt tggaaacatc attgtataac aagcgagttc acgttttaca ac
#ttgtttgt  23340
aacattgtac ttgatcatct ggaccacaat cacccgggcg ttgccatacc at
#cgtttgga  23400
taatactccg ctcggggggt tgtccggtaa atttaaaata taaccgtgtt gg
#ggtcgacg  23460
gatcttttgt atggcgaaac gcgtcaataa gcgaggaccg tccctccgtt gc
#cgcgagta  23520
caaccattct cggcccagtc caattatact ggtcaaacat atttgccggt at
#aggaatat  23580
acagttgttc tgtttccaaa ctacagtgaa taattaatcc ttcgtcgctg aa
#tattaaaa  23640
tagaatccct tagtctatta accagaggtg atatagacga aattaaacca gt
#aagcgttt  23700
tttccgttaa aacagctctg gcgatttctg gggcgtcaaa acccgcatgc aa
#ttccatgt  23760
ccaaagcatc gtctgtacgc gacctcaaat ccataattta ctacttaaaa tg
#tttactat  23820
agaaaaagta atcatatgta aacacacgag tttcgttaat atgtttgttt aa
#cccgatcc  23880
ggtgacttaa gtacataaac aggcatgata tttgaatagt acggcccatg gg
#agggaaca  23940
tttccacgtg ttccaataca gggggtgttc cttaataggg actgtgcaat aa
#aatacgta  24000
agaagttacc agatttgatg taatgtttgt cataaaaaat atgtacatca tt
#atatacgt  24060
ctgtaattaa cacaagatca catcgaagaa ttactgaagc cgctgtgaaa cc
#tttcacaa  24120
gacgatataa acttggttaa gtgtattgat ggggctcttt ggactgacac gc
#tttatcca  24180
tgaacataaa ctggttaaac ccagcatcat ttcaacgcca cccggagttt ta
#acccccgt  24240
ggcggtagac gtatggaacg tcatgtacac attgttggaa cgtttatacc ct
#gtgggtaa  24300
acgcgagaat ttacacggac catctgtaac gatacattgt cttggagtct ta
#ttgcggct  24360
attaacacaa cggtcatact atccgatatt tgtattggaa cgttgtacag ac
#ggcccatt  24420
atcacgtgga gccaaggcaa ttatgtcacg ggccatgaac cacgatgaaa gg
#ggaacctc  24480
ggacttaacc cgtgttctac tatcatccaa cacatcatgt tctatcaagt at
#aacaaaac  24540
atcggaaaca tatgacagtg tgtttcgaaa ctcttccacg agttgtattc ct
#agcgaaga  24600
aaacaaatcc caggatatgt ttttggacgg ttgtccacga caaactgaca ag
#acgatctg  24660
cctgcgcgac caaaacgtat gcagtcttac ctctacaatg ccatcccgag ga
#catcctaa  24720
ccatcgatta tatcacaaat tgtgtgcaag tcttattaga tggatggggt at
#gcatacgt  24780
cgaggcggtt gacattgagg cggacgaggc atgtgcaaac ttatttcata cg
#cgtacagt  24840
ggctttggtt tatacgacag atactgattt actcttcatg ggctgtgata tt
#ttgttaga  24900
tgcaattcct atgtttgctc cagtagtacg atgtcgcgat ttgcttcaat at
#ttaggaat  24960
tacataccct gaatttttgg ttgcctttgt tcgctgtcag accgatttgc at
#acaagtga  25020
caacctaaaa tctgttcagc aagttattca ggataccggc ctgaaagttc ca
#catcaaat  25080
ggacacttca acgcgctccc ccacttacga ctcgtggaga catggcgagg tt
#ttcaaaag  25140
tcttaccgta gccacgtcgg gtaaaacaga aaacggagtg tccgtttcca aa
#tatgcatc  25200
taaccgatcg gaggtgacag tagacgccag ttgggcttta aaccttctgc ca
#ccctcatc  25260
ctccccattg gataatttgg aacgcgcatt tgttgaacat ataatcgccg tg
#gtaactcc  25320
attgacccgc ggtcgcctaa agttaatgaa acgtgtaaat attatgcaaa at
#acggcaga  25380
cccatatatg gttattaaca ccttatatca taacttaaag ggggaaaaaa tg
#gctcgcca  25440
atacgcacgt atttttaaac agtttattcc tactccactc ccactaaaca ct
#gtattaac  25500
aaaatattgg aattaaaaca cacataagag cgacttaatg gttcattgtt tt
#attttgct  25560
cgtatataca tgttataaat cgtttatcac tgtgcccgca taagatgtac tg
#tgtctctc  25620
aaaaaaattt gtgtttttat ctgcaatcat aaatgcaagt ggaaagtccg aa
#tcgggagg  25680
tggggtgtta aatagttttg gtacattaat cgctgataaa agcctgtccg cg
#ctgaattt  25740
cacgtattgt gtaattgcat cgacgttcac caaacgggtt ttgggtgcat gg
#gattttaa  25800
aaacgcacac tcgatttcaa cggcttccga aaacagttga tgtattctgg tg
#atagcggg  25860
tttttcgggt acatagttat tgtatataca acacgatgcg ctggtatgta tg
#gcttcatc  25920
tcggcttata aggtcgttaa attgacaagt tacaacaaat agtccgttat tg
#cgtaaata  25980
tgcaatagcc gcgaacgatg atacaaaaaa aatgccctct ataagaatca tt
#agtatata  26040
tttttctgca acggatgggt tgtcccgtac cttttcttcc aaccattgta ct
#ttttgttg  26100
gatcgacgga ttattaatag tgacatttac gtattgtacc cgcaacgatt ca
#tcccctct  26160
gaacaacatt agttgaattt gactatagac acgcgcgtgg acaacctcga tg
#cactcttg  26220
ttcaatgtag taatggtgaa tatccttttg ggaaaagagt tgggttagag ag
#cccaaatt  26280
aacatttacc agatcatctg ccgccgataa aaatgtaaaa ataaatctgt ag
#aatattag  26340
ttcatcttcc gttaaacagt ccaagtattg ataatcatct tcaatgataa aa
#tcgctttc  26400
taaccaacga ttcgaaatgc tcagggcacg taaattgttt atatctggac ac
#tccggcct  26460
gtaaaaaaaa tgactgcaat ctttctgatc cattttggaa tagtttcccg tg
#taaattta  26520
taaagcacaa ctggtacagg ttaattcgcc tcccgcaaac agtccgctgt tc
#gtagcttt  26580
acgaatttta cagtagtaca tacccgtttt aaggccggct ttataggcac gt
#ataagcaa  26640
attcattatt ttggaggcgg gaattgtccc gtctgggcgt tcctcaataa at
#aaagtcat  26700
tgattgactt tggtcaataa atggcgccct ttctgcacac atatcaacga ga
#tcctcttg  26760
ctcatattca aacgctgttt tatattttaa gagtgggtga ctattagata aa
#cagccaaa  26820
cgaacgtatt actgaccatt ggtttttctc aagtatgttt ataacttcca gt
#cgtttttc  26880
ttcacatgaa tacatatctc ttagttcgtc cataaggtct aagttgggtc ta
#agtaactc  26940
acccgaggtg gtgaccttac taaacatatt attataaatt ggagagaaac cc
#tcactgca  27000
ctccgttacc tgtgcagatg aaactgtggg cattaacgct aagaactgcg ag
#ttgtataa  27060
cccataagcg caaatatcat ctcgcagggt acaccatggt aaatctaaat aa
#cttatcgt  27120
agaaaaccca tcttggtgta accatccctt agcatattta ctttcggtaa aa
#cccttaaa  27180
cggggctaag ccgccaatct tacacatttc catgcttgtt ttcattgtct ca
#tacaacat  27240
taactccgct atttgtacat ttaaccgtct agctggttgg gaagttaaat ca
#aatcctaa  27300
gcggagacaa gttgtatgta acccttgtat gccaatgcca agtgatcggt tg
#ttttttac  27360
acctttacat gattttttac atggaaagtt cccagccgcc aggaccccgt tt
#aaaaaaat  27420
aacagtcgtt cttgctgtca attgaaggtc gtttaaatta aatgacactg gg
#cctttgga  27480
taagcacgtt gtaagattta tgctggcaag attacatacg ccatgttgat ga
#gcgtctgc  27540
cttttgaaca atttccgtac acaaatttga ccccgtgata gcatttcctt gg
#gtattcat  27600
atgataatta cgattacagg catctttgaa cattaaaaag gggcttcctg tt
#acagcagc  27660
actgcgtatg attgtgaatg cgatatcttg aatgggaaca gaagaaacgc ct
#aatccttc  27720
tctctctaaa cgtaaatagg ttgaagtgaa tgcctccccg tgtaatgttc ga
#aggatatc  27780
ggctctgtta tcaaaaagag tccactgaac attactagcc ccttttagat ag
#cttaggta  27840
tctttcaaaa aataaatctg gggtccataa acaacaaaat atgttatcac at
#cgaaatat  27900
ttcatcacga accaacattc cacgtgtggc caaaacagtt tgtagatcga cg
#tgccatgg  27960
ttctatgtaa acacaaactc cagttggtcg ttcacaatca ctgttaattg cc
#ataaccat  28020
gcaatctaaa agttttaaaa ctgcaagaag acctttcgtt tgattttccg ta
#ggtattaa  28080
attcagactc tgtagagaaa ttcccactcc acctcgactt tgtaataccg tt
#cccacatc  28140
gcctgtgata gctcgaacag ctctcccaac agtgatggat tccgggtcca tt
#aaataaca  28200
actggccgtt gccccggtct ctcgacctaa aaacatcata accggtgtag cc
#gggacaat  28260
tttctgacat gccaacgctg tgaaaaatac ccgacagaca tcagtccatg ta
#taaccatc  28320
atttattccg ggaataagag ttgcgatttt aggcaggttt acgatttctg tt
#gtcacggt  28380
ggccgccagt cttaaaaaga attggcaaag cgactctaat ttaccttcct ct
#aacttagt  28440
taaataaaag tcttcgtact ttaaagcaga ctgtagtcca agggtagcta aa
#gcggggta  28500
ttgatctttc aaaaacggtt ctaatatagc ccgacgaatt tcgtccctcc gc
#ccttcaat  28560
tgcttggcgg actcggggag ttaaacagag aattggggaa gtcaaccacg tt
#tccatgga  28620
aacggatcgt aggttaatac ggcaatggat aagttctcca caacatcggt ac
#actcgctc  28680
atcttgtcgc gtcaccgcct taagttttga gacgatagtg ctaatatact cc
#attaattc  28740
caccggtgtg gttgattcgg gcggaatgat gtattccttg tagccatgtt ga
#cataatcg  28800
gtttataatg tcatgaaccg tattaaaaat tcttttgaac tccataacgg at
#aacgtatt  28860
taggctccgg aataaacctt taaaccctaa actcacagct gagttagttc ta
#caatattg  28920
tagactccct tatatatggt tacgtacagc ctgcccctcc ccagtatata at
#atcacgca  28980
aaacccacgc tatgttaaat tcagtttatt ttacatacat gctttaataa ta
#acattcgt  29040
tccatgtatt tgtacccccc cacacaaccc cctctaacca aatagttggc ac
#gttataac  29100
ctccgaaccg ttccatgcgt cttgtataac gcacagactc tgatggaatt gt
#tccaatta  29160
acgtatatgc cgcatacatg caggataatt gtgtgggaag tccccgaaaa tc
#gccggtcc  29220
attgatacaa tcgctgtcta gccaagttcc aatttactcc tgtaatttcg cc
#aatactac  29280
atcgagggct tgtcgggtca ttggataact gcacaagcgg caacgccctt gt
#gttatatg  29340
gctggtgggt atttgcaacc ccttcagtcc cccaggcggc attttcagct cg
#tatgcgtc  29400
ctaacaggaa gccaatacca cgaccaaaac attgttcgtt tagttggctt aa
#tgcaagat  29460
gcagtcttac accttctcgt tggcgtcgct gtgtatatac aaaaaccaag aa
#cacatgct  29520
tcagtccgtc cgcggaaaga tgtaaatctt tgtcaacgtc ccaaaatacg ca
#ggccggga  29580
tgttggctgt gaccctgcga gttgaagttt tgtctgtacg tgcagcttct tg
#gggacctt  29640
tggccacggc ggttatattg cataaattat cctgaatggt atattccagc ag
#ggacccaa  29700
aaaaacttat aaatcgatgt ggaaatacat gacattgtac catcgcacgt aa
#acactccg  29760
aaaaccttat gagccgcgtt tccatacgac tgcatccata ggcagaaaca at
#tgctgttc  29820
tgttggcatc cgctgcctgt ttatccgtat attcttctgc ccggcatgcg gc
#gatgaaac  29880
ttaatgacgt tacatatgct ctaagccccc caccttctcc aacggtccaa gg
#agccgtgc  29940
aggcattgaa taggtttcgt aaaccctcta gtagtacatc ggggtcacgt cc
#agcctgtg  30000
taagtgtatt agcttctcca atcatgtcag atggatgacg aaggattaag ac
#gattgacc  30060
cagcatgctc aatgtccgga cgaaaaaaat cggttaatga cacttgttgg at
#tagctgtg  30120
tcgttgattt aaaattattt aacgggagtc taatggtaac ttgcgggtta cc
#aattgaag  30180
ttggatttat ttgaatgttg ttcatacgat taataacaat tgaacggggg gt
#tacttgaa  30240
tagacgcggt ttctgtacgt tttggtggta catgtatcgg ttgtttgttc ag
#acctccaa  30300
agcgagggcc aattgttaaa tcgcgactcc aatttccgaa gaagcccgga gc
#ataagtca  30360
tatgaagccc gttccctatt tgaataaaac ggttatttcc taaaagactg at
#attagttc  30420
cacatagcgt ttgttcgttt aaagtaaaat gcgagttggt tggttgactc cc
#catagctg  30480
aggggttaaa ttcacacaat gcaatcgtga cgtggtacta tctgaaatgt tg
#cctggggt  30540
atgtgtacac attatacagt cgtagtaccg tttatataat gttaggtagg ag
#gagcctat  30600
aaaaatattt tgattggcgt taaaaggttc ttcaacttac cgtgacgtcc tt
#tttattaa  30660
catgcgtttt tattgatgtt acatttatgt cttttcattc cggacggatg ta
#gctttttc  30720
atatcacgtt ataaagttaa gtcagcgtag aatataccat ggaagaacca at
#ttgttatg  30780
atacacaaaa acttttggat gatttaagta acttgaaagt acaagaagcg ga
#caacgaaa  30840
gaccatggtc accagagaaa acagaaatcg ccagagttaa ggtagttaag tt
#tttacgat  30900
ctacccagaa aattccagct aaacatttta ttcagatatg ggaacccctg ca
#ttctaata  30960
tctgttttgt atattccaat acatttttgg cggaggctgc tttcacggcc ga
#aaatttac  31020
ccggactgtt gttttggaga ctagatctag actggacgat agaggagcca gg
#taatagct  31080
taaaaatttt aacccagcta tcaagtgtag tacaagattc cgagacgtta ca
#tcgtttat  31140
cggccaataa attacgaacc tcgtctaaat ttggacccgt ttcgatacac tt
#cattataa  31200
cggactggat aaatatgtac gaggtcgcct taaaggatgc aacaacagcc at
#tgaatcac  31260
cattcactca cgctcgtatt ggaatgttgg aaagcgccat tgcagcttta ac
#acaacata  31320
aatttgcgat catttacgat atgccatttg ttcaagaggg gattcgtgtt tt
#aacacaat  31380
atgcaggatg gcttcttccg tttaatgtta tgtggaatca gattcaaaat ag
#ctcactca  31440
ctcctctaac acgagccctt tttataatct gtatgattga tgaatatctc ac
#ggaaacgc  31500
cagtacatag catatcagaa ttatttgcag atactgtaaa tttaattaaa ga
#tgaggcgt  31560
tcgtatccat cgaagaagcg gtaacgaatc cacgaacggt gcacgagtca cg
#aatttcct  31620
cagctctggc ttatcgagac ccttatgttt ttgagacatc cccgggaatg ct
#tgctagga  31680
gacttagatt agacaatggt atatgggaaa gcaacctctt atcgttgtcc ac
#ccccggaa  31740
ttcatattga ggcgctgtta catttactaa actccgaccc ggaagcggaa ac
#cacatctg  31800
gaagtaatgt agcagaacac acccgtggca tttgggaaaa ggttcaggct ag
#tacatcgc  31860
ctagtatgtt aataagcacc cttgccgaat ccgggtttac aagattttca tg
#caaattgc  31920
tacgtcggtt tattgctcac cacacactcg ccggttttat tcacggaagc gt
#tgtagcag  31980
acgagcatat tacagatttc caacaaacac taggatgtct cgctttagtg gg
#tggactgg  32040
cataccaatt agtggaaacg tacgctccta ctaccgagta tgtgttaaca ta
#tacacgga  32100
cagtaaacga gaccgaaaaa cggtatgaaa cgctattacc cgccttagga tt
#accaccgg  32160
gaggcctggg acaaattatg cggcgctgtt ttgctccacg accccttatt ga
#aagtatac  32220
aagcgacacg cgtaatacta cttaatgaaa tttcacatgc agaagctaga ga
#gacaacat  32280
attttaagca aacacataat caatcctcag gtgcgttatt accacaagca gg
#acaaagtg  32340
ccgtacgcga agccgtacta acctggtttg acctacgtat ggattcaaga tg
#gggtatta  32400
ctcccccggt ggatgtgggt atgacacctc ctatttgtgt tgatccaccg gc
#tacagggt  32460
tggaagctgt catgataaca gaagcactaa agattgcata tcctaccgaa ta
#taatcgct  32520
ctagcgtgtt tgtggaaccg tcgtttgtgc cttatattat tgcaacaagc ac
#gcttgatg  32580
ccctttcggc aacaatagct ttgtcttttg atacacgggg aatacagcaa gc
#cttgtcta  32640
ttcttcagtg ggctcgcgat tatggatccg gaaccgtgcc caatgcagat gg
#atatcgca  32700
caaaactatc tgctcttata acaatattag aaccttttac ccgtacacac cc
#cccagtac  32760
ttttaccatc tcacgtttct actatagatt cccttatatg cgaacttcat cg
#gactgttg  32820
gcattgccgt tgacctgctt ccccagcacg tccgtccttt ggttcctgac cg
#tccttcta  32880
ttacaaatag cgttttttta gcaactctct attatgatga actttacggt cg
#ttggaccc  32940
gactggataa aacatcgcag gcgttggttg aaaattttac atccaacgcg tt
#agtggttt  33000
ctcggtacat gttaatgtta caaaaatttt ttgcgtgtcg tttttatcca ac
#gccagatc  33060
ttcaggctgt tggtatctgt aacccaaagg ttgaacgcga tgaacaattt gg
#ggtatggc  33120
gtttaaacga tcttgctgat gcggttggtc atattgttgg gacaatacaa gg
#aatccgaa  33180
cgcaaatgag agtgggaata tccagcctgc gcacaattat ggccgatgct tc
#ctcagccc  33240
ttagggaatg tgaaaattta atgactaaaa cctccacttc tgctattggg cc
#tctttttt  33300
caacgatggc ttcccggtat gcacggttta cacaggatca aatggacatt tt
#aatgcgtg  33360
ttgacaaact aacaacagga gaaaatatac ccggtcttgc aaatgtagag at
#ttttttaa  33420
ataggtggga acgaatagca acagcttgta ggcatgccac ggcagtcccg tc
#ggccgaat  33480
ctattgcaac cgtgtgtaat gaattgaggc gcggtttaaa aaatatacaa ga
#ggatcgtg  33540
taaatgcccc aacctcatat atgagtcacg cccgaaatct ggaagatcac aa
#ggcagcag  33600
tttcattcgt tatggactcc aggcaacagt ttattgtgga ttctggacct ca
#gatgggcg  33660
cggttttaac ttcacaatgt aatataggaa catgggagaa tgtaaatgca ac
#gtttttac  33720
atgataatgt taaaataacg acaacggtca gagacgtaat ttcagaggct cc
#gacgctga  33780
taataggaca aagatggctt cgtccagatg agattttatc taatgtagat tt
#gcgtcttg  33840
gcgtacccgg gaatacaagt gggagtgacc cttaatataa aacaggcgtg tt
#tatgtaca  33900
ttaaagtatt tgtggttttt attgactggg cgtttcgttt gtataacgct gt
#tgttgcta  33960
gtattttcat aacctcctag gtttttggag ctacacgtgc ttattcaacg ct
#ctttggga  34020
tttgaatcat cgtaaacgta gcgtccctac cagttgagcg cgtaattttc gt
#aagcaata  34080
aaatggatat aattccgcct atagctgtca ctgttgcggg agtgggaagc cg
#taatcaat  34140
ttgacggtgc cctgggaccg gcgtcaggtc tgtcatgttt aagaacatct tt
#atcgtttt  34200
tgcatatgac atatgcgcat ggaattaatg caaccctgtc atcagacatg at
#tgatggat  34260
gtttacaaga gggtgcagca tggactacgg atctgtctaa tatggggagg gg
#tgtcccag  34320
atatgtgtgc tcttgttgat ctccccaatc gaatttcata tattaaactg gg
#ggacacta  34380
ccagtacgtg ctgcgttttg tctagaatat acggcgatag ccattttttt ac
#cgttccag  34440
acgagggttt tatgtgcaca caaattcccg ctagagcgtt tttcgatgat gt
#gtggatgg  34500
gacgtgaaga gtcgtataca attataactg tagactcaac gggaatggcc at
#ctatcgtc  34560
agggaaacat atcttttatt tttgatccac atggccatgg gactatagga ca
#ggctgtag  34620
ttgttcgggt gaataccacg gatgtgtact cttatatcgc atcggagtat ac
#ccaccgcc  34680
ccgataacgt agaatcccaa tgggccgctg cattagtttt ttttgtcacc gc
#aaacgacg  34740
gtcccgtaag cgaagaagcg ctatcttcgg cagtaacgct tatatacgga ag
#ctgtgata  34800
catattttac agatgaacaa tattgcgaaa aactggttac agctcaacat cc
#gttgcttc  34860
tttcacctcc taattccacg acaattgtgc ttaataaatc gtctatagta cc
#tcttcacc  34920
aaaacgttgg tgaaagtgta tccttggaag caaccctaca ttcaacgtta ac
#caacacgg  34980
ttgcactgga ccctagatgt agttacagcg aggttgatcc ttggcatgcg gt
#tctagaaa  35040
caacctcgac tgggtctggc gttttggatt gtcgtcgtag acgccgtcct tc
#atggactc  35100
ctccttcaag cgaggaaaat ttagcttgta tcgacgatgg cttggtaaat aa
#tacacatt  35160
ccacggataa tttacataaa cccgctaaaa aggttctcaa atttaaacca ac
#tgtagacg  35220
tgccggataa aacacaagtg gcacatgtat taccccgcct acgagaagtt gc
#taacaccc  35280
cagacgttgt gttaaatgta tccaatgtag atacgcctga atccagtccc ac
#tttttcac  35340
ggaacatgaa tgtaggaagc agtttgaaag atcggaagcc atttctattt ga
#acagagtg  35400
gtgatgtcaa catggttgtc gaaaaactac tacaacatgg gcatgaaatt ag
#caatggat  35460
acgtacaaaa tgcggtgggt acgttggata ctgttattac cggtcataca aa
#tgttccca  35520
tttgggtaac aaggcccttg gttatgccag acgaaaagga tccattggag ct
#ttttatta  35580
acctcaccat tttgcgttta acgggatttg tggtggaaaa tggaacacgt ac
#acatcatg  35640
gtgctacaag cgttgtatca gactttatag gtccccttgg ggaaatttta ac
#aggatttc  35700
cctccgccgc ggaacttata cgcgttacaa gtttgatatt aacaaacatg cc
#gggggcgg  35760
aatatgctat taaaactgtt ctccggaaaa aatgtacaat tggcatgctc at
#tatcgcta  35820
agtttggtct agttgccatg cgggttcagg atacaaccgg cgctttacat gc
#cgaactag  35880
atgtgttaga agcggatcta ggaggttcgt cgcccataga cctctattct ag
#actgtcga  35940
caggtcttat aagtatacta aattcgccta ttatttctca tcccggactt tt
#tgccgagc  36000
ttattccaac ccgtacaggg tccctgtctg aacgaatacg tcttctttgt ga
#attagtct  36060
cggcccggga gacacgctat atgcgtgaac acaccgcgct tgtttctagt gt
#aaaggctt  36120
tagagaatgc attacggtct acccgcaata aaattgatgc cattcaaata cc
#agaagttc  36180
cccaggaacc cccggaagaa accgacattc cacccgaaga gttaattcgg cg
#tgtatatg  36240
agatacgatc cgaagttaca atgctattga cctcggctgt tacagaatac tt
#cacccgcg  36300
gagtgttata tagcacacgg gccttgatcg ctgaacaatc ccctaggcgt tt
#tcgggtcg  36360
cgaccgcaag tacggcaccc attcaacggc ttttagattc tcttccggaa tt
#cgacgcta  36420
aattaacggc aatcatatcg tccctgtcta tacaccctcc tcctgagact at
#acaaaatc  36480
tccccgtcgt atctctgtta aaagagctta ttaaagaagg ggaagattta aa
#cacagaca  36540
cggctctcgt atcgtggtta tctgtagtcg gggaagctca aaccgcaggt ta
#cttatcca  36600
gacgagagtt cgatgaatta tcacgtacaa ttaaaaccat taatacacgc gc
#aacgcaac  36660
gggcttccgc ggaagcagag ttgtcttgct ttaatacgct aagcgcggcc gt
#agaccaag  36720
ccgtaaagga ctatgaaaca tataacaatg gtgaggtcaa gtatcctgaa at
#aacacggg  36780
atgatttatt agcaacaatt gtacgtgcta cagacgattt ggtgcgacag at
#aaaaattt  36840
taagtgatcc aatgatccaa tccggtttac aaccttcgat taaaagacga tt
#ggaaacaa  36900
ggcttaaaga ggttcagacg tatgcaaacg aggcccgaac cacacaggac ac
#aataaaga  36960
gtcgaaaaca ggcggcatat aataaactcg gggggttact tcgcccggta ac
#cggttttg  37020
tgggacttag ggctgcagta gatttattac cggaacttgc ttctgagtta ga
#tgtccaag  37080
gagccctggt aaatctcagg accaaagtct tagaggcgcc ggtagagatc cg
#ttctcaac  37140
ttacgggtga tttctgggcg ttatttaacc aatatcgaga cattttagaa ca
#tcccggaa  37200
acgcacgcac atctgtctta ggaggactgg gagcttgttt tacagctatt at
#cgaaattg  37260
tgccgatacc tacggagtat agaccatcat tgcttgcgtt ttttggtgac gt
#ggcagatg  37320
tgcttgcatc cgacatcgcg accgtatcta ctaacccgga aagtgagtcc gc
#cataaacg  37380
ctgttgttgc aactcttagt aaagcgacgt tagtttcatc tacagtgcca gc
#cttatcct  37440
ttgtgttgtc gttatataaa aaatatcagg ctttacaaca agaaattacg aa
#tacccata  37500
agttgactga attacaaaaa caacttggag atgacttctc caccctagct gt
#ctcatctg  37560
gacacttgaa gtttatatca tcttcaaatg tagatgatta tgaaataaac ga
#tgcgatat  37620
tatcaataca aacaaatgtg cacgccctaa tggatacggt taaacttgtt ga
#agttgaac  37680
tgcaaaagct acccccccat tgtattgctg ggacatctac cttatctcga gt
#agtaaagg  37740
atcttcataa actcgtcaca atggcacatg agaagaagga acaggcaaaa gt
#gttaatta  37800
ccgattgtga acgtgcacat aaacaacaaa cgactcgggt tttgtatgag cg
#ttggacac  37860
gtgatattat agcatgtctg gaggcaatgg aaacgcgcca tatatttaac gg
#gacagaac  37920
tggcacggtt gcgagatatg gccgctgcgg gagggtttga tatacacgca gt
#ttacccac  37980
aagcacgtca ggttgtagcg gcatgtgaaa ctacagccgt tacggcatta ga
#tactgtgt  38040
ttcgccacaa tccatatacc cccgaaaata caaatattcc accacctttg gc
#tttgttaa  38100
gagggttaac atggtttgat gatttttcga ttacggctcc cgtattcacc gt
#tatgtttc  38160
caggtgttag tattgaggga ctccttctgc ttatgcgtat tcgcgcggtt gt
#gttattat  38220
ccgccgatac gtctattaat ggaataccta actaccgaga tatgatatta cg
#aacctcgg  38280
gggatctatt acaaataccc gcattggctg ggtatgttga tttttacaca cg
#gtcttatg  38340
atcagtttat aaccgaaagt gtaacgttaa gtgaacttag agcagacatc ag
#acaggctg  38400
ccggggctaa acttacagaa gcaaataagg ctttggagga agtaactcat gt
#tcgggcac  38460
acgaaacggc taaacttgca cttaaagaag gtgtcttcat tacattacca ag
#cgaaggtt  38520
tattgattcg ggctatagag tattttacaa ctttcgatca taaacgattt at
#aggaacgg  38580
catatgaaag agttttacaa acaatggtag accgcgatct aaaggaggcc aa
#cgcagagc  38640
ttgcacagtt tcgtatggtg tgtcaggcaa caaagaaccg tgcaatacaa at
#tttacaaa  38700
acattgttga tacggccaat gccactgagc aacaagaaga cgtggatttc ac
#taacctga  38760
agacgttatt aaaactaacc ccccctccca aaacaattgc attggccatt ga
#tagatcta  38820
cttccgttca ggacattgtc acgcagtttg cattgctgtt agggcgtctg ga
#agaagaaa  38880
ctggtacgtt ggacattcag gcggttgact ggatgtacca agctcgcaat at
#tattgact  38940
cccatccact aagtgtgcgt atagacggta ccggccccct gcatacttat aa
#agataggg  39000
tggataaact ttatgcgtta cgaactaaat tagatctcct acgacgacga at
#agaaaccg  39060
gtgaggttac gtgggacgat gcatggacaa catttaaaag agaaacgggg ga
#tatgttgg  39120
catcggggga cacgtacgct acttccgtag atagtataaa ggcactccag gc
#atcggcgt  39180
ctgtggttga catgctttgt tccgaacccg aatttttttt attgcctgtg ga
#aacgaaaa  39240
accgtctcca aaaaaagcaa caggaacgta aaacggcgtt ggatgttgtg tt
#gcaaaaac  39300
aaagacagtt tgaagagacc gcgtctcgct tacgagcttt aattgaacgt at
#tccaacgg  39360
agagtgacca tgacgttctt cgtatgttat tacgtgattt cgatcaattt ac
#acatttgc  39420
ctatatggat aaaaacacag tatatgacat ttcgaaattt actcatggta cg
#gttaggct  39480
tgtatgcaag ttatgctgag atttttccac ccgcgtctcc aaacggagta tt
#tgctccta  39540
ttcccgccat gtcgggtgta tgtctagaag accaatcccg atgcattcgc gc
#gcgggtgg  39600
ccgcgtttat gggggaggcg tctgtggtgc aaacgtttag ggaagccaga tc
#ttctatag  39660
acgctttgtt tggaaaaaat ttaacctttt acttggatac tgatggggtt cc
#acttcgat  39720
atagagtgtg ttataaatca gttggggtta aacttggaac catgctatgc ag
#tcagggtg  39780
gattatcttt acgaccggca cttcccgatg aaggtattgt ggaagaaact ac
#actatcgg  39840
cattacgcgt ggccaatgag gtcaatgagc tacgcattga atacgaatcc gc
#tataaaat  39900
ccgggttttc tgccttttcc acctttgtta ggcatcgcca cgccgaatgg gg
#taaaacca  39960
acgcacgcag agccattgca gagatatacg ccggccttat aacaacaaca tt
#gacacgac  40020
aatacggggt tcattgggac aagcttattt attcttttga aaaacaccac ct
#aacttctg  40080
taatgggcaa tggactaact aaaccaatcc agagaagggg tgatgtacgc gt
#attagagt  40140
taaccctatc tgatattgta actattttgg ttgccacaac cccggtacat ct
#tctcaatt  40200
ttgctagatt ggatttaatt aaacagcatg agtatatggc ccgtaccctc ag
#acccgtaa  40260
tcgaggccgc atttagaggt cgtttactcg ttcgctcatt ggatggagac cc
#gaaaggca  40320
atgcccgggc cttttttaat gccgccccat ccaaacataa actcccgtta gc
#tcttggat  40380
caaaccaaga tcctaccggc gggagaatat ttgcatttcg gatggcagat tg
#gaaacttg  40440
ttaaaatgcc acagaaaata acggatcctt ttgcgccatg gcaactttcc cc
#cccccccg  40500
gggtaaaggc caatgtcgat gcagttaccc gtataatggc aacagatcgt ct
#tgcgacca  40560
ttactgtact tgggcgcatg tgtctcccgc caatttcctt agtgtcaatg tg
#gaatacgc  40620
tgcaaccgga ggaattcgca tacagaacac aagatgatgt ggacattata gt
#tgatgcga  40680
gactggattt gtcatccacg cttaatgcaa gatttgatac cgctcccagc aa
#taccacgt  40740
tagagtggaa tacagaccgt aaagtaatta cagatgctta tattcaaacc gg
#ggcaacga  40800
cagtttttac agtaacgggg gcggcaccaa ctcacgtttc taatgtaaca gc
#gtttgaca  40860
tagcaactac ggctatttta tttggggctc ctttggttat tgccatggaa ct
#tacatccg  40920
ttttttcaca aaattccgga cttactttgg ggttaaaatt attcgattcc cg
#gcatatgg  40980
ctacagattc gggtatatcc tcagccgtat ctcccgatat tgtttcttgg gg
#gttacgtt  41040
tactgcatat ggatcctcac ccaattgaaa atgcatgttt aattgtccaa ct
#agaaaaac  41100
tgtccgcgct cattgcaaac aaacctctta caaacaatcc cccgtgttta ct
#gctattgg  41160
acgaacatat gaatccctct tatgttttat gggaacgaaa agactcgatt cc
#agctccgg  41220
attatgtggt cttttggggg ccagaatctc ttattgattt gccgtacatc ga
#ctccgatg  41280
aggactcttt cccctcgtgt cccgatgatc cattttactc gcaaattatt gc
#cggttatg  41340
cgccccaagg ccccccaaac ctcgacacaa ctgattttta cccaacggag cc
#actattta  41400
agtctcccgt tcaagttgtt agaagttcca aatgtaaaaa aatgcccgtc cg
#gcccgcgc  41460
agcccgcgca gcccgcgcag cccgcgcagc ccgcgcagac cgtccagccc gc
#gcagccca  41520
tagaaccggg cacacaaata gtggtacaaa attttaagaa accccaaagc gt
#aaaaacaa  41580
cccttagcca aaaagatatt cccttgtatg tggaaaccga atcagaaacg gc
#tgtgctta  41640
tacctaagca attaaccacc tccattaaaa caaccgtttg taaaagtatt ac
#cccaccaa  41700
ataaccaatt gtcggattgg aaaaataatc cacagcaaaa ccaaacgtta aa
#ccaagcgt  41760
tcagtaaacc aatacttgag attacctcca ttccgacaga tgactcgata tc
#ttaccgga  41820
cttggattga aaaatcaaat caaacacaaa aacggcatca aaatgaccct cg
#aatgtata  41880
actccaaaac agtattccac cctgtaaata accaattacc ttcttgggtt ga
#cacggcag  41940
ccgatgcccc ccaaacggac ctattgacaa actataaaac aagacagccg tc
#gccaaact  42000
ttccgcggga cgtacacaca tggggcgtat cttctaaccc gtttaactca cc
#gaacagag  42060
acctatatca aagtgatttt agtgaacctt ctgacggcta tagcagtgag ag
#tgaaaatt  42120
ctatcgtact aagtctcgac gaacatcggt catgtcgcgt tcctaggcac gt
#acgcgttg  42180
ttaatgccga tgtagtcacc ggtcgacgtt atgtccgagg gaccgccttg gg
#agcactgg  42240
cactgttaag ccaggcatgt cggcgtatga tcgacaacgt tagatataca cg
#taaacttt  42300
taatggacca cacggaagat atatttcaag gcctggggta tgttaaattg tt
#attagatg  42360
gaacatatat ataaagtagc gcctattaaa gaaaaaaaaa aaacaacgat ta
#ttttctgt  42420
gtatttttat ttacacccta cgacttcttg aagcgtttcc agattgtccc gt
#gtgtgaca  42480
aggtctgtcc cttacccccc tggggggtat tttgggttgg gggcggggta ga
#ctgtggca  42540
cgccttgggc cgcgggcggt gatccggttg ttggctggac agtgcttgac tg
#tgctccct  42600
gttgcggttg ttgtccagaa gaccccgaca ccacgtgttg ctgttgtcca ac
#ggatgccg  42660
acgtcgtttg aggtgggggg tgttgcgggg atgatcccga aaacgccaac gc
#ggcgggct  42720
gttgtaaagc agactgatcg gcgctctgtg ttttttgcgg caatatagta gg
#ccccgaga  42780
ttcccaaact catggatgga tttgggggtt gtggtcgtat aatacgcggg tt
#aaacgtac  42840
gttttaagcc aaccgttggt cttaaccatg tcatagggtc agtctcggca aa
#catggccg  42900
ttcggcgtat cgtatttgca ttatggttag cgcgtgcacg cgcggcactg gc
#cgcggctc  42960
ccacggtgta aatgcttctg gcatcagcga tgtccacacg gtgaccaggt tg
#caaaggtc  43020
cactggcgtt taaaagtcgt attaaagcaa cgggggtgta agccgcaatt gc
#ttccaccg  43080
aaaatgtggt ggggttgctg ggatcaaaga ctacacgaga cgatgcgggt tg
#tgtcatcg  43140
tttattagtt tacgggacaa tcgataacag catacacgta catctgcgca gg
#atatgtac  43200
ggaaaggcaa tttatttcca gaaaagcacc gcccctaata caactaccag ta
#caattaca  43260
atgaacaggg catatgtcac gttagctacg ggtagagcaa gtttccagac ac
#gcgtagtt  43320
tgggtatcgg gtaacgcagg tttaatgtca ctttgcattt gaacagacgt gt
#ttggactt  43380
ccgttctcgg gtggggatct gaatgaaggc cgccagcgta tatattcatc ca
#aattattg  43440
ccagtttcct tatacatgta tgcatccgtg gcgcgggcca taagtttaat gg
#tgcgagat  43500
ggatcttccg gtcccataaa acgaaaggat aactgaacat atggcattcg ca
#caaagcag  43560
ttcacccaca ttaaagcctg gagaggtcgg cggtcaatac ccccacctcg tt
#taattgat  43620
tccaaagcag ataggttgat accggtactt aacgttgaac taagaatcac gt
#tattactg  43680
tcaatggaca cttcagccac tggtgcgtta gtcggacgaa aaaaaaaacc tt
#gaaatagc  43740
acagacaccc ccgtattttg aatttttatg taagggtcac aatctacttg cg
#cccaattc  43800
gccattaaac gcataatata ctctaccgga aaggcttcgg atacgttgtc tt
#cgccgtta  43860
aactgaaaaa cacaacgggc gggggggcgt tgtggatcaa atattggaag at
#ccccatcg  43920
caacattgaa gagcgcttgg taccaccaac cgaatacgtt gtaaaagatt at
#ctccgcaa  43980
cccctcctgc gttcactccg tacatacgtt ctccgtgaca tattgatcta ag
#gttgcaaa  44040
ccaaggcaca cgcgtgaagt atttagacca tttatcgtgg gatataggag ga
#gtttggag  44100
tgatccaccc cctgacgact tattaatgcg tttattttcc ccatgtatta ag
#catccttc  44160
aatatttcat gcaaatctag aaatttggcc atgactcccg caaagcgttc ac
#ggcgacgg  44220
gtcacgctgg cactatgttc acatggaaca acataagcag atttttctga at
#cgttactt  44280
tctttatgtt ttaaaacgga cgccaggcga ctggtaaatg atatataatt ta
#attgagcg  44340
tcagttgtag gtagaattgc ttctatttcc gggggaatta aattttcaaa cc
#aaacggaa  44400
agagtaaagg tgctatcagc aggaaaatac tttgactcca gtgcatcgat at
#ttaataga  44460
ttaacatcgg tgtctgtaat taaatcgcgg gccctcatcc cagagatgga tc
#gggtagaa  44520
tcagaagaac ccatggatgg attcgaatcg cccgtattct ccgaaaatac at
#cttctaat  44580
tccggatggt gttccgacgc attttccgat tcgtacatcg cttataatcc ag
#cccttctg  44640
ctaaaaaacg atttgttatt ttcagaattg ttatttgcct cccacttaat aa
#atgttccc  44700
cgtgcaatag aaaacaacgt cacttatgag gcctcttcgg cggtaggtgt gg
#ataatgaa  44760
atgacctcaa gtaccactga atttatagaa gaaattggag acgttttggc gt
#tagacaga  44820
gcctgtttgg tctgcagaac gcttgatttg tataaacgta aatttggact ga
#caccggaa  44880
tgggttgcgg actacgccat gttatgtatg aaaagtctgg catccccgcc ct
#gtgcagtt  44940
gtcactttta gcgctgcctt tgaatttgtg tatcttatgg atcgttacta cc
#tgtgccgt  45000
tataacgtta ctttggttgg gtcctttgcc aggcgcacgc tttccctgtt ag
#atatacaa  45060
agacattttt ttttgcatgt atgttttcgt accgatggag ggttaccagg ta
#tacgaccg  45120
ccccccggta aggaaatggc caacaaagta agatattcca attactcctt tt
#ttgtacag  45180
gcggtagtta gggctgcatt actatcgatc agcacgtctc gtttagacga aa
#ccgaaacg  45240
cgtaagtcat tttactttaa tcaggacgga ctgactggag gccctcaacc tt
#tagcggcc  45300
gccttggcta attggaaaga ttgcgcgcgg atggttgact gttcatcatc gg
#aacatcgc  45360
acaagtggga tgattacctg cgcggaacgt gcattaaaag aggatataga gt
#ttgaagat  45420
atattaatag acaaacttaa aaaatcgtct tacgtagaag cagcttgggg tt
#acgcagac  45480
ttggctttat tattactgag tggggttgct acttggaatg tagacgagcg ta
#caaattgt  45540
gctatagaaa ctcgcgttgg atgtgttaaa tcatactggc aggcgaaccg ga
#ttgaaaac  45600
tccagggacg ttccaaaaca attttccaaa tttacgagcg aggatgcctg tc
#ccgaagta  45660
gcatttgggc ctattttgtt aactacctta aaaaacgcaa agtgccgtgg tc
#gcacgaat  45720
accgaatgca tgttatgttg tttattaacc atagggcact attggatcgc tt
#tgcggcag  45780
tttaaaaggg atatattagc atactcagca aataacacaa gtttatttga ct
#gtatcgaa  45840
cctgtaatca atgcatggag cctagataac cccattaaac ttaaatttcc at
#ttaatgat  45900
gagggtcgat tcataaccat tgtaaaagca gcaggttccg aggccgtata ta
#aacattta  45960
ttttgcgatc tcctatgcgc tctctcggaa ttacagacaa accctaaaat tt
#tatttgcc  46020
catcctacaa ccgcggataa ggaagtgttg gagttatata aagcccaact gg
#ctgcacaa  46080
aacagatttg aaggtcgtgt atgtgctggc ctgtggacat tggcgtatgc at
#ttaaagcc  46140
taccagattt ttccacgcaa accaaccgcc aatgccgcat tcatacgaga tg
#gaggactt  46200
atgcttcgac gacatgcaat atcgctggtc tccctcgaac acaccctatc ga
#agtatgtc  46260
taggcgatat aaatccgtat ctcggagcgg gccttcgatg cgtgtacgct cc
#agaacgcc  46320
atgccgccgt caaaccattc gaggaaaact tatgtcaaag gagcggtctg tg
#taccgcca  46380
ttattttaat tacatcgcaa ggtccccccc agaagaacta gctaccgtta ga
#ggcttaat  46440
cgtgccaatt attaagacga cccctgtcac ccttccgttt aacttgggtc ag
#acagtggc  46500
ggataactgc ctgtcgttat ccggaatggg ttatcattta ggtctcggag gt
#tattgtcc  46560
gacatgcact gcatctggag aaccgcgtct atgtcgaacc gatcgggcgg ct
#ctgatact  46620
agcatatgtt cagcagctta acaacatata cgaatatcgt gtgtttcttg ca
#tccatttt  46680
ggcgctatca gaccgagcca acatgcaagc agcgtccgct gaacccctat tg
#tcgagcgt  46740
attggcacaa ccggaattat tttttatgta tcatattatg agggaggggg gc
#atgcgaga  46800
tatacgcgta cttttttatc gtgatggaga tgccggaggg tttatgatgt at
#gttatatt  46860
tccggggaaa tctgttcacc tccattacag actaatcgat catatacagg cc
#gcgtgtcg  46920
ggggtataaa atagtcgcac acgtttggca gacaacattt ttactgtcgg ta
#tgtcgcaa  46980
cccagaacaa caaacagaga ctgtggtgcc atccattgga acatcggacg tt
#tactgtaa  47040
aatgtgtgac cttaactttg atggagaatt gcttttggaa tacaaaagac tc
#tacgcatt  47100
atttgatgac tttgttcctc ctcggtgatt tcagcttcag tgttcatttt at
#tatcccag  47160
cacggggcgt gtatacaaac aaagcctgcc gcctgcaagc ggtttagcat tt
#taacgtta  47220
acaactcgtg tctctggaat aaaacgtttt aaaagccgtt ctgtgagttt ag
#tgtcgttt  47280
ccaaataacg ccttaaaagt tacactcgcc gtcccaatga gatgagaaaa at
#aatagtca  47340
atgtttaaag acagcccgtg tgatgttacg tgaatgggat cttccgctaa gt
#cagatatt  47400
attaacttac gctttgcttc cccacaccgt ttacctgcgg tattctgtaa ag
#gatctcca  47460
cgtagcaaag ctacactttt tgcatcagcc tccacttcgt ctgtgggggc ca
#caataaca  47520
taagggatgc gttctcgaac gtttgggatt tgaccctgtc tcattactaa tt
#tataatat  47580
actgttaagt gagccaagcg acggtttatg taggcggatg gtggacgact aa
#gctcggcc  47640
gtcataacaa acttattaat atccaatttg ggtgatgtaa tctggcgatg tg
#catctgca  47700
attatgcgtc caaacccggc catcccagac ggcatggccc gtctattcca tt
#cagcaatg  47760
gaaacacacg acgcctccgc cgcagcacgc gagacggtgt cgtcatataa ca
#acagttct  47820
acaagtttgc gggcataatc gttaataaat tgacagttgt tttttctaac ca
#agtcgact  47880
cccttcatta aaacctttcc gccgtaaatt accccaatgt actttttctt tg
#ttataagc  47940
aaaagtttta taaaagtttt ttcacactcc aactttatag gaggacaaaa ca
#gagccgtt  48000
gaaattatat gtgccatttt ctcgccgatt ttagctatcc cctcaacact aa
#cacccttg  48060
aatcggataa acacagaatc cgtatctcca tatataacct ttacctcgta cg
#ctttttgg  48120
gagagaacgc tactttcaat gtctggaaac gctgtaataa aacgttcaaa tg
#cggcccag  48180
ttattatgaa tataatctct ggtacttaat aacatttgac ggccaattgt ag
#tgacagtg  48240
gccgctacgt ataaacatgg cagaaatccc tgcgcaactc cagtaaaacc gt
#acacggaa  48300
ttacaaacta cttttatcgc ggcttgttgt ttgtctaata acactgcttc at
#ctgaagaa  48360
cttccgggta tgcgcgctct aatagccttg cgcatagcca accagtcttt ta
#aaagaaca  48420
cccagcagac tttctcgaac gttagagcgc acaaaaaaaa gacgttttcc tc
#caactgta  48480
aaggtggcat aatcggatgg attcaaacgt ttaaccgtct caaaatttaa cg
#ttagcgtg  48540
gtaaaacata agttatgggc ctgaattata cttggatata aacttgcaaa at
#ccaatacg  48600
accaccggat cgatataaaa tcccgtatca gggtcaaaaa ccctggctcc tt
#tatatcct  48660
acatttcgcc cacttgacgt accagtggga gaaacgctct cgtcttcatc ca
#tctcttcc  48720
tcaacatccc cgacatcggg aataacatcc ttatattcaa aagtagctgg gt
#atccccca  48780
tcgggtaaaa taaatcctcg agacgaagcc agtcctaata aacaggtgta aa
#tcctaacc  48840
tgctgtccgt cgtaaatagc cttggttaaa gtaattctag ctagccttgc aa
#ccgcggat  48900
aactcaaggt gtggtaaata tttaaaaaac agtttcccca caagagccga gt
#cttgtata  48960
caatattcac caataattcc tcgtgtattc ggtccactag cgtaatatcc cg
#gaatgtct  49020
ttgtagggca aatctctctt ggactcattt agagcttcac gtgcaaccga at
#ctaattta  49080
taactcgaga gttttaattt ttcagttgca attgcataca tatccagaga ta
#tgagaccg  49140
ttgatcttta ccttgcttcg tcgctgaaat ccggatttgc caacatccca ta
#tcttaaac  49200
agacccccac ggtttatact gccataacca tcaagcttga gactgtatat ag
#aattaagt  49260
ttctccataa taaacgccca atcaaaatta acaatgttat aacctgtggc aa
#actcggga  49320
gcgtactgtt ttacgagggt cataaatgca attaatagct cgaattcact at
#caaactcc  49380
agcacagtcg gctccggtaa ccccgcgtcc ttcatttctt gtacatacct tt
#gtggtaag  49440
tcacaagagc caagggaaaa cagtaaaatg tgttctaaag actgtcgagg ga
#ttgaatat  49500
aatagacaag aaatttggat tacaagatcc tccagatgtg ttgcatcggg aa
#acgccagc  49560
tcattagatc ctcctgattt acattcaata tcgaaacata acaacttgta gt
#caggccat  49620
gagtcatcgt ttggtatagc ctgcagatta tccgacatgc agtcaatttc aa
#cgtcgctt  49680
aacgttaatt ggcgacttgc cggtcgaact cgaacacgtt ccccatcaac tc
#caggtttt  49740
agttgatacc aaccaaaact aacaaagccg ggattatcca ttagaaaacg ag
#tggtagcg  49800
tctacccgac cttcatactt tttcaactcc gggtgaaagt tatcacaaag at
#aatttgta  49860
aatttagatg agggagaata caccctgtaa aacgcacatg gctgtgtatc gt
#agtaataa  49920
acatctgtgc gctcaataac ctcaacgcga aagctttctg gagatgcgct tt
#taaacgag  49980
gtaccatgaa aagcgttctt gtctccattt aacgttgcat cattttgtgt ta
#tcatagaa  50040
ctgcgtaaac actcggcaag taatacagat aactcgctac cggaacgtat gc
#cacaagcg  50100
gtatccacct cggctttgtt tatataaaaa tattgacaga tgccgtatac at
#gaactgcc  50160
accctttttc cacatcggga catgccaagt aaagtaataa cggtaccaag cg
#gtcgtgtt  50220
gcagttgcaa accgggatac atctccatta gacgcggctt ctgttgtttc ga
#caatatca  50280
tatacatgga atgtgttaaa gcgggggtca aacttatccc cacgaaagtc ga
#tttccccc  50340
caaatattca cgcgtctagg ccaggggctg gaacaacgaa aatccagaat cg
#gaacttct  50400
tttccattac agtaaacttt aggcggtcga ctaagtgtac cgacgtgaac cc
#cctttcgt  50460
tcttccatgg gcacatcttc atctaaacat ttaggggcca aaaattgaaa cg
#atgacatg  50520
gtagttttgt aactatgaag aaattctctg ttactaccgc gcccggttct tg
#ggttatat  50580
ttaatccctg atgcttgggt taaaaaggga ttacaaaacc ccgttctgat cg
#ccatttta  50640
tgttaacgat tgataatctt gtaaaaagcc agtgttactg agtaacacaa cc
#ccacgccc  50700
ttctaataca taaagtgtaa tcacgtgatt tgttgtggtt tccgcatatg ta
#atacccgt  50760
ttaaaagcct ctcttcttaa tgtatcgaca gactgggttt tgggtggtca tt
#tgaccctg  50820
ccaacaaccc cccattatta cgagtacttc accaaaatgg aaaatactca ga
#agactgtg  50880
acagtgccca cggggcccct gggttacgtt tatgcgtgcc gggttgaaga tt
#tggatctg  50940
gaggaaattt catttttggc cgctcgtagc acggactctg atttggcttt at
#tacctttg  51000
atgcgtaatt tgaccgtgga aaaaactttt acatccagcc tggcggtggt tt
#ctggagca  51060
cgcactacgg gtcttgccgg agctggtatt accttaaaac tcactaccag tc
#atttctat  51120
ccatctgtct ttgtctttca cggaggcaaa cacgttttac ccagctccgc gg
#ccccaaat  51180
ctcacacgcg cgtgtaacgc ggctcgagaa cggtttgggt tttcacgctg cc
#aagggcct  51240
cctgttgacg gtgctgttga gacgaccggc gctgagatat gcacccgcct tg
#gattagag  51300
ccagaaaata caatattata cttggtggtc acggcattgt ttaaggaagc cg
#tatttatg  51360
tgcaacgtgt ttctgcatta tggaggactc gatattgttc atattaacca tg
#gggatgtt  51420
atacgtatac cgttatttcc ggtacaactt ttcatgcccg atgttaaccg tc
#tggtaccc  51480
gacccattca acactcatca caggtctatc ggagagggtt ttgtataccc aa
#cacccttt  51540
tataacaccg ggttgtgcca tttaatacat gactgtgtta ttgctcccat gg
#ccgttgcc  51600
ttgcgcgtca gaaatgtaac tgccgtcgcc cgaggagcgg cccaccttgc tt
#ttgatgaa  51660
aatcacgagg gggcagtact cccccctgac attacgtaca cgtattttca gt
#cctcttca  51720
agtggaacca ctaccgcccg tggagcgcgt cgaaacgatg tcaactccac gt
#ctaagcct  51780
agcccatcgg gggggtttga aagacggttg gcgtctatta tggccgctga ca
#cagccttg  51840
cacgcagaag ttatattcaa cactggaatt tacgaagaaa ctccaacaga ta
#tcaaagaa  51900
tggccaatgt ttataggcat ggagggcact ttgccaaggc taaacgctct gg
#ggtcatat  51960
accgctcgtg tggccggggt cattggtgcg atggttttca gcccaaattc tg
#cgttgtat  52020
ctaactgagg tggaggatag cgggatgacc gaagccaagg atgggggacc gg
#gtccatca  52080
tttaatcgat tttaccagtt tgccggacct catttagctg cgaatcccca aa
#cagatcga  52140
gatggccacg ttctatccag tcagtctacg ggttcatcaa acacagagtt ta
#gcgtggat  52200
tatttggcac tcatttgtgg atttggagca cccctgttgg cgcgactgct tt
#tttatcta  52260
gaacgctgtg acgctggtgc gtttacaggg ggtcacgggg atgcgttaaa at
#atgttacg  52320
gggacctttg actctgaaat tccatgtagt ttatgtgaaa aacacacgcg gc
#cggtatgc  52380
gctcacacaa cagtacaccg acttagacaa cgcatgccgc gatttggaca ag
#ccacccgt  52440
caacctattg gggtgtttgg aacaatgaac agccaatata gcgactgcga tc
#ctctagga  52500
aactatgctc catatttaat ccttcgaaaa cccggggatc aaacggaagc ag
#caaaggca  52560
accatgcagg acacttatag ggctacacta gaacgcttgt ttatcgatct ag
#aacaagag  52620
cgactactgg atcgcggtgc cccatgttct tccgagggac tatcgtctgt ca
#ttgtggat  52680
catccaacgt ttcgtcgcat attagacaca ctgcgtgcgc gtatagaaca ga
#caacaaca  52740
caatttatga aagtgttggt tgagacccgc gattataaga tccgtgaagg at
#tatccgaa  52800
gccacccatt caatggcgtt aacgtttgat ccatactcag gagcattttg tc
#ccattacc  52860
aattttttag ttaaacgaac acacctagcc gtggtacaag acttagcatt aa
#gccaatgt  52920
cattgtgtat tttacggaca gcaagttgag gggcggaact ttcgtaacca at
#tccaacct  52980
gttttgcggc ggcgttttgt tgacctgttt aatggggggt ttatatcaac ac
#gctctata  53040
accgtaacat tatctgaagg tcctgtatcc gccccaaatc cgacattggg ac
#aagacgcg  53100
cccgcggggc gtacctttga tggggattta gcgcgcgtaa gcgtggaagt ta
#ttcgggat  53160
atacgagtta aaaatagggt cgttttttca ggtaactgta caaatctctc tg
#aggcagcc  53220
cgggcaaggc ttgtaggcct tgcaagtgcg taccaacgcc aagaaaaaag ag
#tggatatg  53280
ttacacgggg ccctagggtt tttgcttaaa cagtttcacg gcctgttatt tc
#ctcggggt  53340
atgccaccaa acagtaaatc ccccaacccg cagtggtttt ggaccctgtt ac
#aacgcaac  53400
cagatgccgg cagataaact tacacacgaa gagattacca ctattgcagc tg
#ttaaacgg  53460
tttaccgagg aatatgcagc aataaacttt attaatctac ccccaacctg ca
#taggagaa  53520
ttagcccagt tttatatggc aaatcttatt cttaaatact gcgatcattc ac
#agtacctt  53580
ataaatacct taacttctat aattacgggt gccaggcgcc cgcgtgaccc at
#catccgtt  53640
ttgcattgga ttcgtaaaga tgtcacgtcc gccgcggaca tagaaaccca ag
#caaaggcg  53700
cttcttgaaa aaacggaaaa cttaccggaa ttatggacta cggcttttac tt
#caactcat  53760
ttagtccgcg cggccatgaa tcaacgtccc atggtcgttt taggaataag ca
#ttagtaaa  53820
tatcacggag cggcaggaaa caaccgcgtc tttcaggcag ggaattggag cg
#gtttaaac  53880
gggggtaaaa atgtatgccc gctatttaca tttgatcgca ctcgccgttt ta
#taatagca  53940
tgtcctagag gaggttttat ctgccccgta acaggtccct cgtcgggaaa tc
#gagaaacc  54000
accctatccg accaagttcg cggtataatt gtcagtggcg gggccatggt tc
#aattagcc  54060
atatacgcca cggttgtgcg tgcagtgggc gctcgagcac aacatatggc at
#ttgacgac  54120
tggttaagtc ttacagacga tgagttttta gccagagact tggaggagtt ac
#acgaccag  54180
attatccaaa ccctggaaac gccctggacc gtagaaggcg ctctagaagc ag
#taaagatt  54240
ctagatgaaa aaacgacagc gggagatggg gaaaccccca caaacctagc at
#ttaatttt  54300
gattcttgtg aaccaagcca tgacaccaca tctaacgtat taaacatttc ag
#ggtcaaac  54360
atttcagggt caactgtccc tggtcttaaa cgaccccccg aagatgacga ac
#tctttgat  54420
cttagtggta ttcccataaa acatgggaac attacaatgg aaatgattta ac
#ctccctct  54480
ttatccaatt aaagcccaca cgcgggtgag tgtacgtaat aaacaagtca at
#attacata  54540
ttctgttgtg ttttcttttt ttgtgtgtag tccttaccca tatgacctgt aa
#tatagtgt  54600
gtctccaacc attcagctta cagtccagtg gacagtaaca gcccgataac at
#ggaattgg  54660
atattaatcg aacattgttg gttctactgg gtcaagttta tacgtacatc tt
#tcaggttg  54720
aactgctacg tcgatgtgat ccaagggtgg cgtgtcgctt tttatatcgg tt
#agcggcta  54780
actgtttgac agttcgttat ttattaaagc tgtttctccg gggatttaat ac
#ccagctaa  54840
aatttggaaa cactcccacg gtttgtgcac tgcattgggc attatgttat gt
#aaagggag  54900
aaggtgagcg tttgtttgag ttgctacaac attttaaaac gcgttttgtt ta
#tggtgaga  54960
ctaaagactc aaactgtatc aaagattact ttgtctcagc gtttaactta aa
#aacctgcc  55020
aatatcacca tgagctgtcg ttaacaacat acggaggtta cgtatcgagt ga
#aattcagt  55080
ttttacacga cattgagaat tttttaaaac agcttaatta ctgctatatt at
#cacgtctt  55140
ctcgtgaggc gctaaacaca ttggaaaccg tgacgcggtt tatgacagat ac
#tataggaa  55200
gcggtctaat accacccgtg gagttgtttg atccggcgca tccatgtgct at
#atgttttg  55260
aagaattatg tataacagct aaccaaggtg agaccttaca tcgtagatta tt
#aggatgta  55320
tctgcgatca cgttactaag caagttcggg ttaacgtgga tgttgacgat at
#tattcggt  55380
gtttaccata tatccctgat gtaccggata tcaaacgtca atccgccgtt ga
#agcgttac  55440
gaacacttca aaccaagacg gtagtcaatc ccatgggagc aaagaacgat ac
#gtttgacc  55500
aaacatacga aattgcgagc accatgcttg attcttataa tgtttttaaa cc
#tgcccctc  55560
ggtgtatgta cgccatcagc gagcttaaat tctggttaac gtctaattcc ac
#tgaaggac  55620
cccaacgtac tttagacgtg tttgttgata atttggatgt attaaacgaa ca
#tgaaaaac  55680
acgcagaact tacagccgta acggttgagt tggcgttatt tggaaaaact cc
#catacact  55740
ttgatagggc gttttctgaa gaactcggat ctctggatgc aattgatagt at
#tttggttg  55800
gcaatcgctc atcctcacca gacagtcaga tagaagcatt aattaaagcc tg
#ttatgccc  55860
atcatctatc gtcgcctctc atgcgtcaca tttctaaccc gagtcatgat aa
#cgaagccg  55920
ccttacgcca acttttagaa agagttgggt gtgaggatga tttaaccaaa ga
#ggcgagtg  55980
acagcgctac agcatccgaa tgtgatctga acgatgatag tagcataact tt
#tgctgttc  56040
atggatggga aaacctgtta tccaaagcaa aaattgacgc tgcggaaaga aa
#acgagtat  56100
atcttgaaca tctgtctaag cgctctctaa ccagcctcgg tagatgtatc cg
#cgaacagc  56160
gccaagagct agaaaaaaca ctcagggtaa acgtttatgg agaggcctta tt
#gcagacat  56220
ttgtttcgat gcaaaatggg tttggggcac gaaacgtgtt tttagctaag gt
#ttcccagg  56280
cagggtgtat tatcgacaat cgcattcagg aagcggcctt tgatgcacat ag
#atttataa  56340
ggaatacctt agttcgacat acagtagatg cggctatgtt acctgcactt ac
#acataaat  56400
tttttgagtt ggtcaacggc ccattgttta atcacgatga acaccgtttt gc
#acaacccc  56460
ctaacaccgc cttatttttt accgtggaaa acgttggcct atttccgcac tt
#aaaagagg  56520
aattggcaaa gtttatgggc ggtgtcgttg gttccaactg gcttctcagt cc
#atttaggg  56580
gcttttattg cttttctggg gtagaaggcg ttacttttgc acagagactt gc
#ctggaaat  56640
atattaggga gcttgtgttt gcaaccacac tattcacctc tgttttccat tg
#tggggagg  56700
tgcggttatg tcgcgttgac cgtctaggta aggatccacg cgggtgcacg tc
#tcaaccta  56760
aaggtatagg cagttcccac ggacccttag acggcattta tttaacgtac ga
#agaaacat  56820
gtccccttgt ggctattatt caaagtggag aaacagggat cgaccagaat ac
#cgtcgtaa  56880
tctacgattc agacgttttt tctcttctat acaccctaat gcagcggctg gc
#tccggatt  56940
caacggaccc ggcgttttca taacctccgt tacgggggtg tggttatgct tt
#ttatgcat  57000
attttctatg tttgttacgg cggttgtgtc ggtctctcca agctcgtttt at
#gagagttt  57060
acaagtagag cccacacaat cagaagatat aacccggtct gctcatctgg gc
#gatggtga  57120
tgaaatcaga gaagctatac acaagtccca ggacgccgaa acaaaaccca cg
#ttttacgt  57180
ctgcccaccg ccaacaggct ccacaatcgt acgattagaa ccaactcgga ca
#tgtccgga  57240
ttatcacctt ggtaaaaact ttacagaggg tattgctgtt gtttataaag aa
#aacattgc  57300
agcgtacaag tttaaggcga cggtatatta caaagatgtt atcgttagca cg
#gcgtgggc  57360
cggaagttct tatacgcaaa ttactaatag atatgcggat agggtaccaa tt
#cccgtttc  57420
agagatcacg gacaccattg ataagtttgg caagtgttct tctaaagcaa cg
#tacgtacg  57480
aaataaccac aaagttgaag cctttaatga ggataaaaat ccacaggata tg
#cctctaat  57540
cgcatcaaaa tataattctg tgggatccaa agcatggcat actaccaatg ac
#acgtacat  57600
ggttgccgga acccccggaa catataggac gggcacgtcg gtgaattgca tc
#attgagga  57660
agttgaagcc agatcaatat tcccttatga tagttttgga ctttccacgg ga
#gatataat  57720
atacatgtcc ccgttttttg gcctacggga tggtgcatac agagaacatt cc
#aattatgc  57780
aatggatcgt tttcaccagt ttgagggtta tagacaaagg gatcttgaca ct
#agagcatt  57840
actggaacct gcagcgcgga actttttagt cacgcctcat ttaacggttg gt
#tggaactg  57900
gaagccaaaa cgaacggaag tttgttcgct tgtcaagtgg cgtgaggttg aa
#gacgtagt  57960
tcgcgatgag tatgcacaca attttcgctt tacaatgaaa acactttcta cc
#acgtttat  58020
aagtgaaaca aacgagttta atcttaacca aatccatctc agtcaatgtg ta
#aaggagga  58080
agcccgggct attattaacc ggatctatac aaccagatac aactcatctc at
#gttagaac  58140
cggggatatc cagacctacc ttgccagagg ggggtttgtt gtggtgtttc aa
#cccctgct  58200
gagcaattcc ctcgcccgtc tctatctcca agaattggtc cgtgaaaaca ct
#aatcattc  58260
accacaaaaa cacccgactc gaaataccag atcccgacga agcgtgccag tt
#gagttgcg  58320
tgccaataga acaataacaa ccacctcatc ggtggaattt gctatgctcc ag
#tttacata  58380
tgaccacatt caagagcatg ttaatgaaat gttggcacgt atctcctcgt cg
#tggtgcca  58440
gctacaaaat cgcgaacgcg ccctttggag cggactattt ccaattaacc ca
#agtgcttt  58500
agcgagcacc attttggatc aacgtgttaa agctcgtatt ctcggcgacg tt
#atctccgt  58560
ttctaattgt ccagaactgg gatcagatac acgcattata cttcaaaact ct
#atgagggt  58620
atctggtagt actacgcgtt gttatagccg tcctttaatt tcaatagtta gt
#ttaaatgg  58680
gtccgggacg gtggagggcc agcttggaac agataacgag ttaattatgt cc
#agagatct  58740
gttagaacca tgcgtggcta atcacaagcg atattttcta tttgggcatc ac
#tacgtata  58800
ttatgaggat tatcgttacg tccgtgaaat cgcagtccat gatgtgggaa tg
#attagcac  58860
ttacgtagat ttaaacttaa cacttcttaa agatagagag tttatgccgc tg
#caagtata  58920
tacaagagac gagctgcggg atacaggatt actagactac agtgaaattc aa
#cgccgaaa  58980
tcaaatgcat tcgctgcgtt tttatgacat agacaaggtt gtgcaatatg at
#agcggaac  59040
ggccattatg cagggcatgg ctcagttttt ccagggactt gggaccgcgg gc
#caggccgt  59100
tggacatgtg gttcttgggg ccacgggagc gctgctttcc accgtacacg ga
#tttaccac  59160
gtttttatct aacccatttg gggcattggc cgtgggatta ttggttttgg cg
#ggactggt  59220
agcggccttt tttgcgtacc ggtacgtgct taaacttaaa acaagcccga tg
#aaggcatt  59280
atatccactc acaaccaagg ggttaaaaca gttaccggaa ggaatggatc cc
#tttgccga  59340
gaaacccaac gctactgata ccccaataga agaaattggc gactcacaaa ac
#actgaacc  59400
gtcggtaaat agcgggtttg atcccgataa atttcgagaa gcccaggaaa tg
#attaaata  59460
tatgacgtta gtatctgcgg ctgagcgcca agaatctaaa gcccgcaaaa aa
#aataagac  59520
tagcgccctt ttaacttcac gtcttaccgg ccttgcttta cgaaatcgcc ga
#ggatactc  59580
ccgtgttcgc accgagaatg taacgggggt gtaaatagcc agggggtttg tt
#ttaattta  59640
ttaataaaaa tgtgtattac gttactcatg tgtctccatt acgcatcaca gg
#gggtattt  59700
atacccgata atatacaaaa cgcgttttgt acctctaccg cacccgatat ct
#taacgggg  59760
ttattatgga atcgtctaac attaacgcgc tacaacaacc gtcgtctatc gc
#acatcatc  59820
cgtccaaaca gtgcgcttca agtctcaatg aaacagtaaa agattctccc cc
#cgcgattt  59880
atgaagatag gttagaacac acgccggtac aattaccccg cgacggtaca cc
#ccgagacg  59940
tatgttctgt gggacagcta acctgtcgag catgtgcaac gaaacctttt cg
#ccttaacc  60000
gcgacagcca atacgactac ttaaacacat gtccaggggg ccgtcatatt tc
#actggcac  60060
tggagattat aacgggtcga tgggtttgca tcccgcgtgt gtttccggat ac
#cccagagg  60120
aaaaatggat ggcgccatat attattccag accgagaaca accatcatca gg
#ggatgaag  60180
attctgacac cgattaaatt taacttaaat aaaaccttac cacccataaa aa
#cgccttct  60240
gtttgtttaa cacgacaccg cttaacaaaa aaaaaaaaac caaacacgcc tt
#ttatgaat  60300
gtaatacttt tatttgttgg ttaacaccgc cccaccatca tctgatttgc aa
#acatatcg  60360
gcgtcgtctg ccgtggaccc ctgtattaaa ggggccttgg aactcgcctc ca
#ctgcattt  60420
acatcttgtc caactgtatc tgtatgtggg gtgcttgttg tattttggga tg
#agcataga  60480
cccgaaacgc tttgaagctg ttttaataaa atcgatattc gaggatcccg tg
#tcccctct  60540
ggtatatttg tatggtgcga caaaggcatt tgtgtcccat tttgtgattt ta
#gctctgta  60600
acctcctgtt gcagttttgc cacaacccca gcaagctctt cgtgctgacc at
#tagaaact  60660
ctgtgtctcc tctgccaata tgatggagaa actcgacgtc tccgatgcgt ta
#tatacgtt  60720
ggttcaccgg gaaaatatat atttgaggga aactctccgt ccatttgaga ct
#ccccacta  60780
taaaaagaat ccaattccct ttgatccatg ctcttgaaat cccgttttcc tg
#gacgacgg  60840
acatcggttt tgtctggaaa atttacacac ggggtctgca agtcaatacc cc
#gttcggcg  60900
gccaatgcgt tcataaatgc ggacatttgc atttccaaac gattgggtgg tg
#gatatccc  60960
ggaaacccgt acggtccccc gaagtgtccc ggagggcaac cataaccccc tg
#tattaggt  61020
gggaaggcag gcgggtgtgg agatccatat ggcccgacga tatactgtcc gt
#tatttgga  61080
gctccaattg atacctgcgg atttttagtc tgcccggtta acagctgtga at
#aatacgcg  61140
gtaggtatca gtacaaattc ccctccggtt ggaacgcccg acgggggctg tg
#gtgagata  61200
ttactagcgt tacctgctac agaagccata tcgctgtcgt tcctacacaa ct
#gcgtaacc  61260
tttaaatgcg gaacagtctt ttcacaatct tcatttgatt ccccaacacc ca
#acgcgaga  61320
tcgtatatgg gcccgccggg gtggaatgtg gcgtttataa cacccgcgtt gg
#gtaattta  61380
gactccaccc cattaacgtt ggttatccga gcaagtccat atccggtgct ag
#cctgaaga  61440
taaacgtgac ccataattcc ggcttcgcgt ctacgttttg caaccacgtc cc
#atctatct  61500
cttaaaagca tattgttcac ggctgtggat aataacacct tggcgagttt at
#cttcgcta  61560
accttccata ctttatttaa acccgcgtag tctttaacca gcgacaataa cc
#gcgcttta  61620
ctttccatcg ataaaacccg gaatggttca attgaagatt ccggggtaca gt
#cataattg  61680
accactgttc caacgcgtct tccaacaaca cataacgcaa catgggtaaa aa
#aattaccg  61740
tctggtatct cattcgggga caatcgtttt gaagacaggg atacggaggg ta
#agtaattt  61800
gtgaccaagt ataacgcacg ttctagcgga gataatacag aatctctatt tc
#caaaaaaa  61860
ttcgaatggg ccgcttcaaa cagcaccgca tgtagttgag ggcatctaac ga
#tacccaaa  61920
aaaaaaggtc cgcgtatgtc ctcaatgatt gcgattactt cacccacgac ac
#agtctttt  61980
cgatgatcga tgtttattgg tattttacta gtaggcggca aagcggaccg ca
#caatctct  62040
ggggtaatat ttaattcccc ttcgtccttt gaatataagg ctaaataccc ag
#ccacgtat  62100
aacgcttcac agttctcttc gtcagcttca gcagccatta taaacacccc ac
#ggaccgga  62160
tagtgaatac tcacggtgtg gaggcaaact gaggaatgac acccaaacag ac
#aaaatata  62220
gaagatcata gtcactgtta acgttgaact gcgcaaggcg gcgactttct tc
#caatgccg  62280
cccttacacg cggttggtgc attaacattc caagtccccg ttcatattgc aa
#cataacac  62340
tgtcatgtat tgataccacg gcggctatgg gtagggatgt aacattttgt cg
#gcggtgtt  62400
ctaattccaa tgcaattaag cttatgagcc gatcttggta ctgtccagaa ga
#aatatcta  62460
ttacggttct tcctaaactt ccacgactaa gctgggtatg cgcgtctaaa ca
#aagagcaa  62520
ctaatccagg aaacatttca gtcagctctg tggtccgatt taacgtatac ag
#tggtgcta  62580
tatatcgttc acataaaaat tgaaagttat tattaccgct tttaaacttc cc
#atcaaacc  62640
ccgtcgctcc gcgcaagatt acattgttgg taggggttcc tgttgcttct ga
#cacaatca  62700
aacccagttg aaaattattt tttagtttat ctccgtatac gttcccgttc ca
#taataagc  62760
gccttaataa taataacgcc gtaatcgtgt caattgttaa ccttaataga gt
#ttggtctt  62820
ccataagaaa cacgttttgg gcccgttcta aatacgccgc ggccgcctgt tg
#aatcttgt  62880
ccacatatgc ggtatgattg cgatcaataa tgtcattaac cccaggatta aa
#ctgtccag  62940
gtgcaggcgg taggacctgc aaccgtataa gcgcatccat aacagaatgt ga
#cgttaagg  63000
cgccttgatc ataccgcccc ccacgagcat gaaactggtc gcgtggtaga cg
#atcatagc  63060
aaaattgata actgttttta ttttcgtgtg ttgtcatata attcacaaat gt
#ctcagtat  63120
attccggtag gtgctctata aggttcccga aggacgaaac ttgaggttcg tg
#gacactat  63180
tagatgtcct atacattaaa tataaacata ataccgcaca ctcgaacgcg ga
#gtacgctc  63240
tatctccaac atacattctc ccggcggact gtagacatgt taccgttgtg tt
#cataaacg  63300
tacgggaaat gcgcccgtct ttacaatcaa ctccgcgtgc agctacgggc ct
#atctaaca  63360
caagccgttc ctgcagagta cgataccatg gcccgaaaac aatccctgga ga
#gttattgc  63420
cccttgccct tcccaagtac accagggtga taaaatccac ttgaaagttt gt
#atcgtact  63480
gcaacggtgc atcatttttg gcaatctgta cctcggggtg tatagactca tt
#gcgtatta  63540
tttctgtacg tgtacattcc tcagattgtg catctgcttc ttccgcctcg gc
#agcagccg  63600
tctccaggga atccaaaacc ttggccatgc gcgttagttg ttcttcgagg gg
#ctttaaac  63660
gacgatctat ttccgttggt aacgtaatcg tttccccgcg aaggttgtct aa
#tgcggcaa  63720
cggccgccgc attttttaac gttaacgtat ttttttccaa atcgggattc at
#acgccctc  63780
ttaactcaaa cgcgggagcc gtccagtagt gtatggggaa gttgggggct at
#aaagttct  63840
tagtggtaga caaaaatatc ccacatttat tcggaaacga gatagatccg aa
#cccatatc  63900
tcgccgtcat ggtgtctgca gcaaacaaag tcaactggcg tgaatataaa cc
#ggtactgc  63960
tttaaaagct gttttcttac ccatgggaaa acatcccggt tatactttgt aa
#aattccac  64020
cacaagcacc taaagaaggc cttctaaggg gtaaatccac cccacaagct gc
#attttctt  64080
caaactttgt taaagcggaa cgatggcatg atttcgcacg ctttttcgca ag
#agaacata  64140
cgtgaatttt ctttttgcat agacgtcttc gctctctaac ggaccttatc gg
#gggggtat  64200
attccgctac attctccaaa tgcgacgcta gcataacaag gtttccatga at
#cacctttg  64260
ggggtaaccg agttacctgt aacaggttca gaccccgttg agatacaaac ac
#aaggaggg  64320
gggtcaccat tatttcatca gatcccgtgg gtgtggtttc ctttattaaa gc
#catggtat  64380
ccctcagctg gcgcataccc tcgcaaaact ggtgatactt agtaggggta tg
#tatattag  64440
cgctaaaacg gcaagatttt aattccacta taaaacaaac ggtctttccg gc
#accactgg  64500
attccgtttg tataatacaa acacaatcgg ggcgtcggcg tcccaaattt ac
#ttcaaacg  64560
acattgatat gcgtacagcc ctttgaacat ccacgtggga taacggcgac ag
#gagttttg  64620
ccagcctcgg gttgaacgcg tccgcgaaac ctcgacgtac gttatcaata tc
#ctttttga  64680
gtacatcgta aaaacgagtg tggcaacgtt gtcccaaacg aaaacacttg gc
#ccgaattc  64740
gactagcgga catatttgaa gttccgtccc agaagataac ctaagacgcg tt
#tgtctaca  64800
ataaacatgt caacggataa aaccgatgta aaaatgggcg ttttgcgtat tt
#atttggac  64860
ggggcgtatg gaattggaaa aacaaccgcc gccgaagaat ttttacacca ct
#ttgcaata  64920
acaccaaacc ggatcttact cattggggag cccctgtcgt attggcgtaa cc
#ttgcaggg  64980
gaggacgcca tttgcggaat ttacggaaca caaactcgcc gtcttaatgg ag
#acgtttcg  65040
cctgaagacg cacaacgcct cacggctcat tttcagagcc tgttctgttc tc
#cgcatgca  65100
attatgcatg cgaaaatctc ggcattgatg gacacaagta catcggatct cg
#tacaagta  65160
aataaggagc cgtataaaat tatgttatcc gaccgacacc caatcgcctc aa
#ctatatgt  65220
tttcccttgt ccagatactt agtgggagat atgtccccag cggcgcttcc tg
#ggttattg  65280
tttacgcttc ccgctgaacc ccccgggacc aacttggtag tttgtaccgt tt
#cactcccc  65340
agtcatttat ccagagtaag caaacgggcc agaccgggag aaacggttaa tc
#tgccgttt  65400
gttatggttc tgagaaatgt atatataatg cttattaata caattatatt tc
#ttaaaact  65460
aacaactggc acgcgggctg gaacacactg tcattttgta atgatgtatt ta
#aacagaaa  65520
ttacaaaaat ccgagtgtat aaaactacgc gaagtacctg ggattgaaga ca
#cgttattc  65580
gccgtgctta aacttccgga gctttgcgga gagtttggaa atattctgcc gt
#tatgggca  65640
tggggaatgg agaccctttc aaactgctca cgaagcatgt ctccgttcgt at
#tatcgtta  65700
gaacagacac cccagcatgc ggcacaagaa ctaaaaactc tgctacccca ga
#tgaccccg  65760
gcaaacatgt cctccggtgc atggaatata ttgaaagagc ttgttaatgc cg
#ttcaggac  65820
aacacttcct aaatatacct agtatttacg tatgtaccag taaaaagatg at
#acacattg  65880
tcatactcgc gtgtacgtgt ttttcttttt tatatatgcg tcatttatta cc
#acatcctt  65940
taatcccgcc tttatctccc taaaacggag tggtaatatt aaaagccgcc aa
#gcctgttg  66000
gtgggtgagg aggggtaaag gcacgctgtg tgcataacgt tgcggtgata tt
#gtagcgca  66060
agtaacagcg actatgtttg cgctagtttt agcggtggta attcttcctc tt
#tggaccac  66120
ggctaataaa tcttacgtaa caccaacccc tgcgactcgc tctatcggac at
#atgtctgc  66180
tcttctacga gaatattccg accgtaatat gtctctgaaa ttagaagcct tt
#tatcctac  66240
tggtttcgat gaagaactca ttaaatcact tcactgggga aatgatagaa aa
#cacgtttt  66300
cttggttatt gttaaggtta accctacaac acacgaagga gacgtcgggc tg
#gttatatt  66360
tccaaaatac ttgttatcgc cataccattt caaagcagaa catcgagcac cg
#tttcctgc  66420
tggacgtttt ggatttctta gtcaccctgt gacacccgac gtgagcttct tt
#gacagttc  66480
gtttgcgccg tatttaacta cgcaacatct tgttgcgttt actacgttcc ca
#ccaaaccc  66540
ccttgtatgg catttggaaa gagctgagac cgcagcaact gcagaaaggc cg
#tttggggt  66600
aagtctttta cccgctcgcc caacagtccc caagaatact attctggaac at
#aaagcgca  66660
ttttgctaca tgggatgccc ttgcccgaca tacttttttt tctgccgaag ca
#attatcac  66720
caactcaacg ttgagaatac acgttcccct ttttgggtcg gtatggccaa tt
#cgatactg  66780
ggccaccggt tcggtgcttc tcacaagcga ctcgggtcgt gtggaagtaa at
#attggtgt  66840
aggatttatg agctcgctca tttctttatc ctctggacca ccgatagaat ta
#attgttgt  66900
accacataca gtaaaactga acgcggttac aagcgacacc acatggttcc ag
#ctaaatcc  66960
accgggtccg gatccggggc catcttatcg agtttattta cttggacgtg gg
#ttggatat  67020
gaatttttca aagcatgcta cggtcgatat atgcgcatat cccgaagaga gt
#ttggatta  67080
ccgctatcat ttatccatgg cccacacgga ggctctgcgg atgacaacga ag
#gcggatca  67140
acatgacata aacgaggaaa gctattacca tatcgccgca agaatagcca ca
#tcaatttt  67200
tgcgttgtcg gaaatgggcc gtaccacaga atattttctg ttagatgaga tc
#gtagatgt  67260
tcagtatcaa ttaaaattcc ttaattacat tttaatgcgg ataggagcag ga
#gctcatcc  67320
caacactata tccggaacct cggatctgat ctttgccgat ccatcgcagc tt
#catgacga  67380
actttcactt ctttttggtc aggtaaaacc cgcaaatgtc gattatttta tt
#tcatatga  67440
tgaagcccgt gatcaactaa agaccgcata cgcgctttcc cgtggtcaag ac
#catgtgaa  67500
tgcactttct ctcgccaggc gtgttataat gagcatatac aaggggctgc tt
#gtgaagca  67560
aaatttaaat gctacagaga ggcaggcttt attttttgcc tcaatgattt ta
#ttaaattt  67620
ccgcgaagga ctagaaaatt catctcgggt attagacggt cgcacaactt tg
#cttttaat  67680
gacatccatg tgtacggcag ctcacgccac gcaagcagca cttaacatac aa
#gaaggcct  67740
ggcatactta aatccttcaa aacacatgtt tacaatacca aacgtataca gt
#ccttgtat  67800
gggttccctt cgtacagacc tcacggaaga gattcatgtt atgaatctcc tg
#tcggcaat  67860
accaacacgc ccaggactta acgaggtatt gcatacccaa ctagacgaat ct
#gaaatatt  67920
cgacgcggca tttaaaacca tgatgatttt taccacatgg actgccaaag at
#ttgcatat  67980
actccacacc catgtaccag aagtatttac gtgtcaagat gcagccgcgc gt
#aacggaga  68040
atatgtgctc attcttccag ctgtccaggg acacagttat gtgattacac ga
#aacaaacc  68100
tcaaaggggt ttggtatatt ccctggcaga tgtggatgta tataacccca ta
#tccgttgt  68160
ttatttaagc agggatactt gcgtgtctga acatggtgtc atagagacgg tc
#gcactgcc  68220
ccatccggac aatttaaaag aatgtttgta ttgcggaagt gtttttctta gg
#tatctaac  68280
cacgggggcg attatggata taattattat tgacagcaaa gatacagaac ga
#caactagc  68340
cgctatggga aactccacaa ttccaccctt caatccagac atgcacgggg at
#gactctaa  68400
ggctgtgttg ttgtttccaa acggaactgt ggtaacgctt ctaggattcg aa
#cgacgaca  68460
agccatacga atgtcgggac aataccttgg ggcctcttta ggaggggcgt tt
#ctggcggt  68520
agtggggttt ggtattatcg gatggatgtt atgtggaaat tcccgccttc ga
#gaatataa  68580
taaaatacct ctgacataaa aaacatgtat aataaaaagt cactataaac gt
#attctcta  68640
caatacttta ttcgcgaata atacacacta cctttgggtt tttttcccgt cc
#ccaaatgg  68700
tgtttggtgc actctaccaa aaaatagagc gcctaaatat gctatataac gc
#ctcccagc  68760
aaaatacggt tcaaaggcat tacccgatat tgtattgtag tacagggcaa tg
#ggaattga  68820
tgatcccaat aaacggcata gacgcacagc gccgttatag caggggtctc ca
#gagtacag  68880
ggtatctaag taccgggata tctcatactc atgcctttcc gtgacagaaa ca
#tcaaccgg  68940
aacagtatcc gataaaccaa ctcctgtttt tgcaaggcgt aaaattcgca ca
#ccttcctt  69000
ttttgcaaga tgtgacgttt ccttgtaaca gggaagctgg gggagtggta ag
#aacaacaa  69060
agtttcagcc aacgtgccaa taaagcccac ttccctcaag aggctgtttg ct
#gtatccac  69120
aatggtccgt attaaatctt gagcaacttg atccgtgtca tcatcactgg gt
#aacgcgtt  69180
aacataacta cgcgttaaat cttcaataac ggcataacaa ttaaacgctt cc
#caccgaga  69240
cagtatatat tgaacaatca cgaaccgttg acaggacgtc agatcacgtc cg
#taagcatg  69300
cccgaaaaat ggaagttccc cccgttcgcc atataccgca acaactgcag ta
#tatatcgt  69360
ctcacgggct tcattaagtt catcttcaag tccaggccat tttctggctt ta
#aatataac  69420
ctcgtccgca aaaaaaaccg cacatgataa cgcgcggata caatgagtag tg
#gctttatg  69480
gcgaggatcc caaatgtcca ttacccgggg gatggtccta atctgtacaa ag
#ttacttag  69540
tgtaatatga tcggacttct tacgccgtct aggctgtttc tcagaatacg gt
#tcacccga  69600
aatcggcaca tcatctgctt ttacgtcttc cgtaaccaca tcagcagcgc gc
#cgactaac  69660
aattatactt gttttttcat cgtcgttact tccgttaagc gcgtctcgta tc
#tcgggcgt  69720
cccgtcgaat aatccactca ctagctcctg caaactttct ggtaactcca ac
#atacgcat  69780
atacaccaat gaaaaactgg cttcgtttgg tacgtacata aagccatttg tg
#gtattaat  69840
ggcggtgggt gttggaaaca attttagctt attctcgcgc gtaacatcta cc
#cccgccac  69900
caatgttaaa tgcgtcacgg ggagggacac gagataatct gcgagcgtag gg
#tcctccac  69960
ttcaacatca aatgttccgc aaaggtcgcg atccaccgcc cccgatcccg ct
#gcaagtaa  70020
ggccactcga tccaaaaaca cgcagttatt attggatgat accgcccatg tc
#ttcccggt  70080
gcgattgagc tcacttcgaa cgtaactggc aacagatctg tcaccgggtc cg
#accccgcg  70140
aacaacatgt ccaaattttg cgatctcgcc tccatgtttg cggggtatgg aa
#attaagca  70200
tcccccgcat ataaaatacg ccctggtagc acgctcgtta aaataaaacg tt
#acgccgtt  70260
ataagatacg gttgaatgat atggaaattc catattaaag cgtttatcgg aa
#cattaacc  70320
tcgaacttgc cgtcccgtga tcgtgtgatc gccaacctta ggtccacacc ga
#atatgaga  70380
aatatataac tacacgcaaa cattcaaaac accgtggtat cattaacgtc at
#atgaaaag  70440
atccaatcaa tccaatcaac cacacctcct accgtttagc acgtcagcta tg
#tgacatgc  70500
tccaaacata cgtaaacatt tagagagggt gttataacag tctgtcaggc gg
#ggtatatt  70560
ctacataata caaggatcgg ctttaacttt gtcaacattt ttactttgga ct
#ataaactg  70620
cgactgaacg ttatgaaccc accccaagcc cgcgtctcgg aacagacaaa gg
#acttgctt  70680
agcgttatgg ttaaccagca ccccgaagag gacgcaaaag tgtgtaaatc ca
#gtgataat  70740
tcaccgcttt ataacaccat ggttatgtta tcgtatgggg gtgatacgga ct
#tactatta  70800
agctctgcat gtacccgcac atctaccgta aacaggtcgg cgtttacgca ac
#actccgtg  70860
ttttatatta tatccacggt gttgattcaa ccaatatgtt gtatcttctt tt
#ttttttac  70920
tataaagcga cacgctgtat gctcttattc acagccgggt tacttctgac ga
#ttctacat  70980
cactttcgac ttattattat gttattgtgt gtctacagaa atatacgatc ag
#acctgcta  71040
cccttatcta catcccagca actgctgctt ggaattattg ttgtgactcg aa
#caatgcta  71100
ttttgtatta cggcgtatta tactcttttt atagacaccc gggtgttctt tt
#tgattacc  71160
ggacacttgc aaagtgaggt tatttttcca gatagcgttt caaaaatact tc
#ctgtgtcg  71220
tggggtccaa gtccagccgt gttactggta atggcggcag ttatttacgc ta
#tggactgt  71280
ttggtggaca cggtatcctt tattgggcca agggtgtggg tccgtgttat gt
#taaaaaca  71340
tctatttcgt tttagtccat ttcaataaat gtactataat tgttcagtct aa
#aaataatg  71400
ttgggtattt ataattaccg cccccgtgtt acttggaaac acccatacat at
#gttccact  71460
ctacatcaaa cttctcgcag ttttcttgtt cccgcacacg tttacacgtc cg
#gattcaag  71520
tcgcaacgct gctgacaaaa tgacaacggt ttcatgtccc gctaacgtga tt
#actacaac  71580
ggaatctgat cgtattgctg ggttatttaa catcccagcg gggatcattc ca
#actggaaa  71640
tgtgctgtca accatagagg tgtgtgcaca ccgttgcatt tttgattttt tt
#aaacaaat  71700
acgatcagat gataacagcc tttactcggc tcaattcgat attcttttgg gg
#acatactg  71760
caatacatta aactttgtgc gttttctaga acttggactg tctgtcgctt gc
#atctgtac  71820
taaatttccg gagctggctt acgtgcgaga tggcgttatt caatttgagg ta
#caacaacc  71880
catgatagca cgtgatggcc cacatcccgt cgatcagcct gttcataatt at
#atggttaa  71940
gcggatacac aagcgttcgt taagcgctgc gtttgcaatt gcatcggaag cg
#ttgagttt  72000
gttaagtaac acatatgtcg atgggacaga gattgactca tcgttacgta ta
#agagctat  72060
ccaacagatg gctcgtaatt tacgcaccgt tttggactca tttgaacgag gc
#actgccga  72120
tcaacttctt ggtgttctat tggagaaagc cccaccgcta tcgctgcttt ca
#ccaattaa  72180
taaattccaa cccgagggac atctaaatcg tgttgcacgc gcggccctac tt
#tcggacct  72240
caaacgtaga gtctgtgcgg atatgttttt tatgacccga cacgccaggg aa
#cctaggct  72300
gatctctgcg tatctgtcgg atatggtttc gtgcacccaa ccatcggtga tg
#gtatcacg  72360
aataactcat acaaacactc gcggacggca ggttgacggt gtgttggtaa ca
#acagcaac  72420
cttaaaacgg caactattac agggaatttt acaaattgac gacaccgccg ct
#gacgtacc  72480
agtaacatat ggcgaaatgg ttctacaggg gacaaacttg gtaaccgccc tt
#gtgatggg  72540
aaaggccgtc cgcggaatgg atgatgtagc ccgccatctc cttgatataa cc
#gaccctaa  72600
cacgttaaac ataccgtcta tacccccaca atccaactcc gattcaacga ca
#gctgggct  72660
tccggttaac gcccgtgttc ctgcggattt agtgattgtt ggggataaac tt
#gtattctt  72720
agaagcatta gaacggcggg tctaccaagc tacgcgcgtt gcctaccctc tt
#attggaaa  72780
tatagatatt acgtttatca tgccaatggg agtgtttcag gcaaactcca tg
#gacagata  72840
tacacgacac gccggcgatt tttcaactgt atccgaacag gatccacgtc aa
#tttccacc  72900
ccaagggatt tttttttata ataaagatgg gatattaaca cagttgactc tt
#cgtgatgc  72960
aatgggtacc atctgccaca gttcattgct tgatgtcgag gccacacttg tt
#gccctccg  73020
ccaacaacat ttagatcgtc agtgttattt tggtgtatac gtggccgagg gt
#acagagga  73080
cacattggat gttcaaatgg ggaggtttat ggaaacgtgg gcagatatga tg
#cctcatca  73140
ccctcattgg gtaaacgaac atttaacaat tctacagttt atagctccga gc
#aacccgcg  73200
tctaaggttt gaattaaacc ccgcctttga tttttttgtt gcaccggggg ac
#gtagacct  73260
tcccggaccg cagcgtcccc cggaagccat gccaaccgtt aacgcaacat ta
#cggattat  73320
caacggaaac attcccgtgc ctctatgtcc catttcattt cgagactgtc gc
#ggaaccca  73380
actcggtttg ggaagacata caatgacccc ggcaaccatt aaagccgtaa ag
#gatacatt  73440
tgaagaccgc gcatacccaa ctattttcta catgctagag gctgttattc at
#ggaaacga  73500
aagaaacttc tgtgcgttac tgcgactgtt aacacagtgt attcgcgggt at
#tgggagca  73560
atcccacagg gtggcatttg taaataactt tcacatgtta atgtacataa ct
#acatatct  73620
cggaaacggt gagcttcccg aagtctgtat taatatatat cgggatttac tg
#cagcatgt  73680
aagagcatta cgccaaacta taaccgattt tacaatacaa ggagagggcc at
#aacggcga  73740
gacctcggaa gcgctaaata acatccttac ggatgacacg tttattgcac ct
#attctatg  73800
ggattgtgat gcgttaatat accgtgatga agccgcccga gaccgactcc cc
#gcaattcg  73860
tgtaagcggg cgaaacggat accaagccct tcactttgtg gatatggccg gg
#cataactt  73920
ccaacgacgc gataatgtgt taatccacgg gagacccgtt cggggagaca cg
#ggtcaggg  73980
tattcccatt actccacacc atgaccgtga atggggtatt ctctccaaga tt
#tactacta  74040
tattgtcatt cctgcatttt cccgcggttc ctgttgtaca atgggcgtgc gt
#tatgatcg  74100
cctataccct gcgttacagg cagttatcgt tccggaaatt cccgctgatg aa
#gaagcccc  74160
aactacccca gaagatccaa gacaccctct tcacgcacac caactcgttc cg
#aactctct  74220
taacgtttac ttccataatg cacacctaac cgttgatggt gatgcattgc tc
#acactaca  74280
agagttaatg ggagatatgg ctgaacgaac gacggccatt ttagtatcaa gc
#gcccccga  74340
tgcgggagcc gccacggcaa caaccagaaa tatgagaata tatgacggag cg
#ctttacca  74400
tggccttatt atgatggcat atcaggcgta cgatgaaacc attgcaacgg gt
#actttttt  74460
ttatcccgtt ccggtcaacc ctctgtttgc atgtccggaa catttggcat ca
#ttgcgtgg  74520
aatgacaaat gctaggcggg ttttggcaaa aatggtacca ccaatccctc ct
#tttctggg  74580
agccaaccac cacgcaacta tacgccaacc cgttgcctac catgtaacgc at
#agtaagtc  74640
ggattttaat actcttacat attctcttct tggagggtat tttaagttta ca
#ccaatatc  74700
tcttacacat caactacgaa cgggatttca ccccgggatt gcctttaccg ta
#gtgcgcca  74760
ggatcgcttt gccacagagc aacttttata tgccgagcgt gcttctgaat cg
#tactttgt  74820
cggacaaatc caagtacacc atcatgatgc tattgggggg gtaaacttta cc
#ctaaccca  74880
acccagagct cacgtggacc tgggagtcgg gtatacagct gtatgtgcca ca
#gcagccct  74940
gcgatgccct ctcacggata tgggcaatac tgcccaaaat cttttttttt ca
#cgaggagg  75000
agtgccaatg ttacatgata acgttaccga atcgttgcgt cgtataacag ca
#tcgggggg  75060
tcgcttaaat cccaccgaac ccctacccat cttcggcgga ctacgtcctg ct
#acatcggc  75120
aggaattgca cgagggcaag cctctgtgtg tgagtttgtg gccatgccgg tg
#tccactga  75180
cctacaatat tttagaactg catgcaatcc tagaggtcga gcatctggaa tg
#ttatatat  75240
gggtgaccgt gacgccgaca tagaggctat aatgtttgat cacacacaat cg
#gatgttgc  75300
ttatacagat cgagcaactc ttaacccatg ggcatcacaa aaacattcat ac
#ggtgacag  75360
gctatacaac ggaacataca accttacagg cgcttctcct atctacagcc ca
#tgctttaa  75420
gttttttaca ccagcggagg ttaacactaa ttgtaataca ctggatcggc tt
#ctaatgga  75480
ggcaaaggct gtggcgtcgc aaagctccac cgacactgaa tatcaattta aa
#cgccctcc  75540
cggttctacc gaaatgacac aggatccgtg tggccttttt caagaagcat at
#ccaccact  75600
atgctcaagc gatgcggcca tgttacgaac ggctcacgcg ggagaaaccg gg
#gcagatga  75660
agttcactta gcccaatatc tgattcgaga cgcgtcgccc cttaggggat gt
#cttcctct  75720
tccgcgataa tttcaccacg cccacatacc cactcccaat aaaagccctg ta
#gagcgcat  75780
tggcatctta cttgagattt ggatacgctc ggccgacttg gtctgtttca cg
#cttcctta  75840
aacaacatgg ctatgccatt tgagatagag gtattgttac caggagaact at
#ccccggcg  75900
gaaacatctg cattacagaa atgtgaggga aaaattatta ccttctcaac cc
#tgcgtcat  75960
cgagcttcac tggtggatat agcgctgtcg tcatattaca ttaacggtgc tc
#caccagac  76020
acgctctcgc tgttagaggc ataccgaatg cgattcgcgg cagttataac ac
#gggtcatc  76080
ccgggaaagt tgttggcgca tgccattggc gtgggtactc ctacacccgg gt
#tgtttatt  76140
caaaatacat cccccgttga tctttgtaat ggcgattaca tctgcttact tc
#ctccggtt  76200
ttcgggtccg cagactcaat tcgcttggac tctgtaggac tggaaattgt tt
#tcccttta  76260
accatccccc agaccttaat gcgagaaatc atcgccaaag tggttgcacg gg
#ccgttgag  76320
cgcacggccg cgggtgctca aattttaccc cacgaagttc tacgaggcgc gg
#atgtcatt  76380
tgttacaatg gaaggcgtta tgaactcgaa acaaatttac aacatcggga cg
#gatcggat  76440
gcggctattc gcacattggt tttaaatcta atgttttcca taaacgaggg at
#gtctgctt  76500
ttattggcgc tgattccaac tttgttagtc caaggagcac acgacggtta tg
#taaattta  76560
ttgatacaaa cggccaattg cgttagagaa accggccagt taattaatat ac
#cgccaatg  76620
ccgcggattc aagacggcca tcgccgattt cccatatatg aaactatttc at
#cttggata  76680
tcaacatcat ctagactggg ggataccttg ggaactcgcg caattttacg cg
#tctgtgtg  76740
tttgatggac cctctactgt tcatccggga gaccgcacgg ccgtgattca ag
#tgtaaaca  76800
ggtgttaata aaaacacaac cagtctagtt acatttcacg cgtcttgttt tt
#atttaata  76860
ggcataaaca cggaatccgg tatacatgaa ctgccaatat acacggacat aa
#ttaatgca  76920
accatcagat catctgacat tgttcccgtg gtacctttac ccgtgtaagt tt
#ttgtgtct  76980
agattaccca taccgccttt aattacctct gtcaggttat ccaactgttt ac
#atagatac  77040
tccacggggt ctacacctaa ctttactgtt agggatacaa gctcctgtga gg
#ctattata  77100
tttccggagt taaatcgttt aacaaaatag tctacggccg gcgttttttg tt
#tttgtaat  77160
aaaaaaaaag ggtacgccac gctacatccg ggaggtatgg aatgataaaa ca
#gtaacact  77220
ggagcggaag atagcacgtt tcccttttcg aggacagcaa actgttgtgc ta
#tagccaac  77280
gatatggcaa ctgcagaatc ctggctgctg tttccctcta tagaaacgtg ta
#cgtttgta  77340
aatgtattgg ggtgtaaagc gagtatgtgg cctaagcatt gagtaacgca ac
#gccctatc  77400
tcactggaag acgtgccagt taaagctcta agaaaaaagt gctccaatcc aa
#atataatc  77460
caatccgact tataacgacc aacaatcgct acaccagtac cagacgctcg tg
#tatttgag  77520
gtaaatgcag ggtctacgta aacgtacaac actgacgata atatagcaca at
#tcgcaacg  77580
gttgacggcc gatataaaat aaacctctca cgggcagttt ttgtaaataa tg
#gccggtca  77640
aaccccacac ccccagaatt ctgtttacgc ccacctacaa tttcctgcac ga
#aggagtcg  77700
gccataaata aatctgcagt gcgccgcatg gctccatcca ttgtgatgaa aa
#ccggctta  77760
tttaatacat aacacgaaca agctgtgaca tcgctatgtg ctaaaacacg cg
#gcatgtga  77820
tcgtcgcata catatgtaac aacgtttaac aactgatccg acgatccacg ta
#agttatac  77880
aaaaaacttg tacttgcttt tccggtattt gttgatgaaa caaaaataat tt
#tacaattg  77940
gtttgattta aaaatccgac tatagtttgt acagcatcag gtcgaataaa at
#tagcttca  78000
tccacaaaca gaagattaaa atcttgacct cggataccct ggaacgatag aa
#agatatat  78060
agttacccca ccaaagttta aatgtatcct taaataccac gtacgtaaaa aa
#tgtttgaa  78120
tacgtacata tttctttttt ttttccagta caaccatatc cggtgtataa tg
#gaagccca  78180
tttggcaaat gaaaccaaac atgcactttg gcataatgat cacacaaaag ga
#ttactaca  78240
cgttgtgata cctaacgcgg ggcttattgc ggccggaata gatcccgcat ta
#ctgatttt  78300
aaagaaaccc ggacaacgct tcaaggttga agtacaaaca agatatcatg ct
#acaggtca  78360
atgcgaaccg tggtgtcaag ttttcgccgc gtacattccc gataacgcct ta
#acaaatct  78420
cttaatacca aaaacggaac catttgtttc acacgttttt tcggccacgc at
#aattcagg  78480
gggattgatt ttatcattgc ctgtttatct tagccccggt ttattctttg at
#gcatttaa  78540
cgttgtagcg atacgaataa atactggaaa ccgcaagcac cgtgatattt gt
#attatgta  78600
tgcagaacta atcccaaacg gaacgcgtta ttttgctgat ggacaacggg ta
#cttttatt  78660
atgcaaacag ctgattgcgt atatccgatg cacccctcgt cttgcatcgt ct
#ataaaaat  78720
atacgcagag catatggtgg cagccatggg tgaatcacac acgtcaaatg gg
#gacaatat  78780
tggacccgtt tcatccataa tcgatcttga tcgacagtta acttctggag gt
#attgatga  78840
ctcccctgct gaaacacgca tacaggaaaa taatcgggac gtccttgagc ta
#ataaaacg  78900
ggccgtaaac attgttaact ccaggcaccc cgtccgacct tctagttccc gc
#gttgcatc  78960
tgggttgctt caaagtgcaa agggccacgg agcgcaaact tccaacacag at
#ccgatcaa  79020
taacggttcc tttgatggcg tccttgagcc gcctggacaa gggcgattta cg
#ggaaagaa  79080
aaacaattcg tccgccagca tcccaccttt acaagacgtt ctattgttta cc
#ccagcttc  79140
gacagaaccc caaagtctta tggaatggtt cgacatctgt tatgcccaat ta
#gttagcgg  79200
ggacactcca gcagatttct ggaaacggcg tcccctatca attgtaccgc ga
#cattacgc  79260
agaatccccc agtccgttga ttgtagtatc ttacaacgga tcctctgcct gg
#ggaggacg  79320
tattaccgga agtccaattt tatatcactc tgcacaggct attattgatg ct
#gcgtgtat  79380
aaatgcccgg gttgacaatc cccaaagcct acatgtgaca gctcgccaag ag
#ctagtcgc  79440
gcgtttaccg tttttggcta acgtcctaaa taatcaaacc cccttacccg cc
#tttaaacc  79500
aggcgccgaa atgtttttaa accaggtatt taaacaagcg tgtgtgacat cg
#ctaaccca  79560
aggtcttata acggagttac aaacgaaccc gactctacaa caactcatgg aa
#tatgatat  79620
tgcagattct tcccaaacgg ttattgatga aattgtagcc cgcacaccag ac
#ctgattca  79680
gactatagtt tcggtgttaa cggaaatgtc aatggatgcg ttttataaca gc
#tccttgat  79740
gtatgcggtt ttggcgtatc tgtcatctgt atatacacga ccacaaggtg gg
#gggtatat  79800
accctacctt cacgcttcct tcccatgctg gttaggtaat cgttctatat at
#ttatttga  79860
ctattataat tcaggagggg aaatacttaa gctttccaag gtccccgttc cc
#gtagcctt  79920
agaaaaggtt ggtattggta attccacaca actgaggggt aaatttatac gc
#agcgcgga  79980
tattgttgat attggaattt gttctaagta tttacccggt caatgttacg cg
#tacatttg  80040
tctaggattt aaccagcaat tacaatccat tttagtttta ccggggggat tt
#gcggcatg  80100
tttttgtatt accgataccc tacaggcagc actacctgca tcgttaatcg ga
#cctattct  80160
agacagattc tgcttctcta ttcccaaccc ccataaataa attagtgtca ct
#ataaaaac  80220
ataacaccag aatctcttca tatgtaattt tacgtcattt ctcccgtttc ca
#ccccctct  80280
taaaatataa aataaccggg tgggtggcat taaacccaca agtacccggg cg
#gcaatccg  80340
ctagactgtt tttctgctca tggaattaca acgcatattt ccgctgtaca cc
#gctacggg  80400
tgcagcgcgc aaattaaccc ccgaggcagt tcagagactc tgcgatgcat ta
#acgctgga  80460
tatgggatta tggaagtcca tcctgaccga tccccgggtg aaaataatgc ga
#tcaactgc  80520
ttttataact ttaaggatcg ctccgtttat cccccttcaa acggatacta ct
#aatattgc  80580
cgttgttgta gccacaattt acatcacgcg cccacgtcag atgaacttac ct
#ccgaagac  80640
ttttcatgta attgtaaatt ttaattacga ggtctcgtac gcaatgacgg cg
#actttaag  80700
aatttatccg gttgaaaaca tagaccatgt ttttggagca acgtttaaga ac
#ccgatcgc  80760
gtaccccctt ccaacatcta ttccggatcc tcgagcagat cccacccccg ca
#gatcttac  80820
accaacgcca aacttaagca actacttaca acccccgcgg cttccgaaaa at
#ccatacgc  80880
atgtaaagtt atttctccgg gagtgtggtg gtcagacgaa cgaaggcgtt ta
#tatgtact  80940
ggctatggaa cctaatttaa tagggctatg tcccgccgga tggcatgctc gg
#atacttgg  81000
ctctgtatta aatcgactcc tcagccatgc ggacggatgt gatgaatgta at
#catagagt  81060
tcacgtgggg gcactgtatg cgttacccca tgtcacaaat catgcggaag gt
#tgtgtgtg  81120
ttgggctccg tgtatgtgga gaaaggccgg tcagcgggaa ttaaaagtgg ag
#gtagacat  81180
tggcgccacg caggttcttt ttgtagatgt caccacctgc attcgaatta cg
#agtactaa  81240
aaatcctcgc attaccgcaa atcttggcga cgttatagcg ggaaccaacg cc
#agtggtct  81300
ctctgtacca gtaaattcat ctgggtggca gctttatatg tttggagaaa ca
#ttaagccg  81360
ggctattatt aacggctgtg gtctgcttca gcgaatttgc ttccccgaga ca
#caaagatt  81420
atcgggtgaa ccggaaccta caaccaccta gtatacctta actcaaccgc cg
#ttgtggaa  81480
aggtatatgt caacatttac agtaatatat taaaggttaa atttataaaa ca
#ctcacgtt  81540
tgtgttgtga cttgacgcga acaccgctgt gctgtaagac ccgtcggtaa at
#gaaaacgt  81600
aatagattcg ccttttacat gatccacgta atttgcccca aaccactgtt cc
#aggcgaga  81660
cttgataccc tcaaacacgg gttccgttgc tttgcgtata tgagccgtat aa
#cccacttt  81720
aattcctcta aacgtggcca ttactaaagc tattaatggt acaagaaacc at
#gttttccc  81780
atgtctacgt ggtaccaaaa acacagttga tttttgtttg aagtgttcta aa
#acactgtc  81840
agaaacactt ggcgtgttaa acactgtacg cagaaagcag tcaactctgt cg
#gcatgatc  81900
gcccaatagc accgatgaaa taaaatgcgt ggtgtgcatg aggatcattt tt
#tgaaacag  81960
ttccaacgtc cccttatatc tgccatagat tggaacgtca acctttgcgc gt
#ttgccatg  82020
acttccacac tcttcaatac tctcaaaaga tgtttccaca aggtacgaaa ac
#cgttgtgt  82080
aaaggtagac aactgacaga aactatccga cagagaaaac gcgcgaaatg tg
#ttcataac  82140
accgctatac gcatttcgat gaggtgctgc ttcttccggt gaatattcat aa
#aactgtac  82200
actactgaca gcctttttta attcagggct tacgtttgca tttaccgaat at
#cgccatgg  82260
tttcaaaact acattggggg tacagttgta ccctgttgac gatagaaacg cg
#ccaaacat  82320
tgcccgtcga gcagtagccg agaacagtgg aatatattca caacagttgt ga
#agcgttcc  82380
aattccggga ataacggcct gatgacgtcg ggttacatct atagcaaaat tc
#agaaacgg  82440
gatttgggtt gcgtttccca gagacccttg ccgcgtggaa cacggggtag gg
#gactccaa  82500
cgtcccaaag cgttcatccc tacgacgctt tagacgttca aaatatctta ca
#gattcttc  82560
accaagcgta cgaccaaaca ttatcaatga catttaacat caattcacgg aa
#tccgcctc  82620
atctcttgta agcagtaaaa caggaagccg cgtcatctta cgtactcgtt ac
#gtatatat  82680
cataaacatt ttcagggccg cattcattca ctttggtcat gtcaggccac ac
#tccaacct  82740
acgcttctca taggcgtaac cgtgtcaaac tagttgaggc gcataaccgc gc
#ggggttat  82800
ttaaagaacg gaccctcgat ctaatccgtg ggggtgcgag tgtacaagat cc
#agcatttg  82860
tgtatgcctt tactgctgca aaagaggcct gcgccgattt aaataaccag ct
#ccgctctg  82920
cagctcgcat agcttcagtt gaacagaaga ttcgtgatat acaatccaag gt
#tgaggaac  82980
aaacaagtat tcaacagatt ttaaatacaa acagacgcta tatagcaccc ga
#ttttattc  83040
gcggtttgga taaaacagaa gacgataata ccgataatat agacagactg ga
#agacgcgg  83100
taggaccgaa catcgaacac gaaaatcata cttggtttgg agaagacgac ga
#agcgttac  83160
ttacacaatg gatgctgacg acacaccccc caacctccaa atatctccaa ct
#gcaggacc  83220
tttgcgttcc caccacaata ccgacggaca tgaaccaaat gcaaccgcag cc
#gatcagca  83280
agaacgagaa tccaccaacc ccacacacgg atgtgtaaat catccatggg cc
#aatccgtc  83340
aactgcaaca tgcatggaat caccagaacg atcacaacag acaagcttat tt
#ttattaaa  83400
gcacggctta acgagagatc caatacatca acgcgaaagg gtggacgttt tt
#ccacaatt  83460
taacaaaccc ccatgggttt ttagaatttc caaattatcc cgtttaattg ta
#cccatctt  83520
cacgctcaat gaacagttat gtttttctaa attacagatt cgagatagac cc
#aggtttgc  83580
gggacgggga acgtatgggc gtgttcatat atacccatcg tcaaaaatag ct
#gtaaaaac  83640
catggacagt cgtgttttta atagagagtt aattaacgcg attttagcga gt
#gagggttc  83700
tatacgagca ggggaaaggc taggtatttc tagcatagtt tgccttttag gt
#ttttcgtt  83760
acaaaccaaa cagctactgt ttccggcata cgacatggat atggatgaat ac
#attgttcg  83820
cctgtccaga cggttgacaa tacctgatca catagacaga aaaattgccc at
#gtattttt  83880
agatttggct caagcgttga cgtttttaaa tcgaacgtgc ggcctgaccc ac
#ctagatgt  83940
gaaatgtggc aatatttttc ttaacgtcga caactttgcc tcgttggaaa ta
#accacagc  84000
agtaatcgga gactatagcc tagtaacatt aaatacgtat tccctttgta ct
#cgagcgat  84060
atttgaagtt ggaaatccat cccacccgga gcacgtacta cgcgtacccc gg
#gatgcatc  84120
gcagatgtca tttcgtttgg tgttgagtca tggaacaaac caaccccctg aa
#atcttgct  84180
tgattatatt aatggaacgg gccttactaa atatactgga accttgcccc aa
#agagttgg  84240
acttgcgatt gatctttatg cattgggcca agcactctta gaagttatcc tg
#ctaggacg  84300
tcttcccgga caactgccca tttcagtaca tcggaccccg cattatcact ac
#tacggtca  84360
taagttatca ccagatttgg cgcttgatac gctggcatat cgatgtgtcc tg
#gcgccata  84420
tatactccca tctgacatcc ccggggactt aaattataat ccctttatac ac
#gccggaga  84480
gctgaacacc cgtatttccc ggaattcttt acgccggata ttccagtgtc ac
#gcagtgcg  84540
ttacggcgta acgcactcaa agcttttcga aggcatacgc attccggcct ca
#ttataccc  84600
agccactgtt gttacatcgt tgttgtgtca cgataattca gaaatacgct cg
#gatcaccc  84660
tttattatgg cacgatcggg attggatagg atcgacataa gcccccagcc ag
#ccaaaaaa  84720
attgcccgtg tgggaggtct acagcaccct tttgtaaaaa cggatattaa ca
#cgattaac  84780
gttgaacacc attttataga cacgctacag aagacatcac cgaacatgga ct
#gtcgcggg  84840
atgacagcgg gtatttttat tcgtttatcc cacatgtata aaattctaac aa
#ctctggag  84900
tctccaaatg atgtaaccta cacaacaccc ggttctacca acgcactgtt ct
#ttaagacg  84960
tccacacagc ctcaggagcc gcgtccggaa gagttagcat ccaaattaac cc
#aagacgac  85020
attaaacgta ttctattaac aatagaatcg gagactcgtg gtcagggcga ca
#atgccatt  85080
tggacactac tcagacgaaa tttaatcacc gcatcaactc ttaaatggag tg
#tatctgga  85140
cccgtcattc cacctcagtg gttttaccac cataacacta cagacacata cg
#gtgatgcg  85200
gcggcaatgg cgtttggaaa aaccaacgaa ccggcggcac gagcgatagt tg
#aagcattg  85260
tttatagatc cggctgatat ccgtactcct gatcatttaa cgccagaagc ta
#caactaag  85320
ttttttaatt ttgacatgct caataccaaa tctccaagtc tccttgtggg ta
#caccaaga  85380
atcggaacgt atgaatgtgg acttttaatc gacgttcgaa cgggacttat ag
#gcgcgtcg  85440
ttggacgttc ttgtatgtga cagggaccct ttaactggca ccctaaatcc cc
#accctgca  85500
gaaaccgaca tttcattttt tgaaattaaa tgtcgtgcta aatacctctt tg
#atccagat  85560
gacaaaaata acccgctcgg tcggacgtac accacgttaa taaatagacc ta
#caatggca  85620
aatctacggg actttttata tactataaaa aacccatgtg taagcttctt tg
#gaccctca  85680
gcaaacccaa gtacacgcga ggccttaata acggatcacg ttgaatggaa ac
#gtttagga  85740
tttaaaggtg ggagggccct tacagaactc gacgcccatc atttgggcct ca
#atcggaca  85800
atctcatccc gagtgtgggt atttaatgat ccggacatac aaaaggggac aa
#ttacaacc  85860
attgcatggg ccactggaga tacggctctt caaattcctg tatttgccaa tc
#cgcggcac  85920
gctaacttta aacaaattgc cgtacaaacc tatgtattat ccggttactt tc
#cagcgcta  85980
aaactacggc ccttccttgt cacctttata ggacgtgtgc gccgaccaca cg
#aggtggga  86040
gtcccattgc gcgtcgatac acaagcggct gccatttacg aatataactg gc
#cgactatc  86100
ccaccccact gtgcggttcc ggttatagcc gttctaacgc ctatcgaagt tg
#atgtgcct  86160
agagtgacac aaatacttaa agacacagga aacaacgcga ttacatcagc at
#tgcggtca  86220
ttgcgatggg acaatcttca tccagcggtc gaggaggaat ctgtggattg tg
#caaacggt  86280
acaacgagct tgttacgtgc aacggagaaa ccgttgcttt gaactcagag tt
#ctttgaag  86340
actttgactt tgatgagaat gtaacagagg acgccgataa atccacacaa cg
#ccgcccac  86400
gagtgatcga tgtaacacca aaacgaaaac cttcgggaaa gagctcccat tc
#caaatgcg  86460
caaaatgtta aaccctgata aaccctgata aacgttctaa taaaaacatc aa
#atcatggt  86520
tggttactgt gaatgtttgt tttattgctt gggggtttac aagtacaacc ca
#cgctactc  86580
ccacccactg tttgatcgct cgtataacag ctcatcctcg cggtccgttt ca
#tatgttga  86640
gtcattttca tagacgtagc cgtagccttg tgatgggtaa tttgtgcggc ga
#gaatttct  86700
atgtgcaggt tttacttttc gtatgtatcc ccgtacccgc tcgggtactc tt
#cttacggc  86760
accgtagaac cgactgcgtt tctgtcgatg atacacatat gcacgcatca at
#ctgagaag  86820
caacatgaca acggaaaaca cggccaggca agccaaggtt ccccgagttg tg
#ggaattaa  86880
ccgtggagat tgaaccgata tagggtcata taatcggtcc atatacgagt gc
#gcggcggt  86940
tcccaacgta gcacaggcca cgagcgttcc cagggacggt cctattaaca cg
#tgtatata  87000
atgcgccaaa attaattctg atactataag atatacaact gacaatgtac ta
#aatgtaga  87060
catggccacg gacaccgatg accacagtcc cgtatgtaga tgattcgcca cc
#acaagttc  87120
cagcattaat gatacaaata ggatacatat cgccatcaac gcagccatca aa
#ttcacgaa  87180
cactgcgcgc gtaggccccg caaggcgata taaaaagacg ctctgctgtc gt
#aaatttgc  87240
gaccgctttt atgttcgttt cgtccaattt tccgcgtcca caaaaatacg tt
#gtaaatat  87300
tacacttgtc gcaaaatgtc caagatataa tgtagcagcc acgccgattt gc
#ttgtaagc  87360
taataataac acaacggcgt ttaataacca caatgacaaa agaccccaaa aa
#agtgttgt  87420
gggatctaca actaaccatg caacaccgga gctttgccgg acacgttgat tt
#ttcgtttc  87480
tcggtgtata atcgcggccg tgatcagtgt atataccgcc atggccattg cc
#gttaaagc  87540
cgtgtagtaa gtaaatgcca caacgctatg tggttccaaa aacaaaaccg gg
#gcgctgta  87600
tccacctcta tttccggacc ataccccccc atctagggtg gcgttaaata ac
#tcataatc  87660
aactacggca gcataaaaac aagggatccc ggtatattca gaagaggcgg ca
#attaacgt  87720
agccaggagc attaccgcac ccaaagtgaa catcatcacc tgaattatcc aa
#attcgcca  87780
attaagcgta tccatttgat gatctaacgc ttccacctcg ggtgtcgtgg tg
#tcgtacgg  87840
cgagactttt tcagaacgcg gccccttctt ttgagttccc atgtctccca ac
#accgggga  87900
gagcaacgcc gccgtctatg cgtccagtac acagctcgcg cgggcgttat at
#ggagggga  87960
tctggtttcg tggattaaac acacccaccc gggaattagc ctggaactgc aa
#ttggatgt  88020
tccagtaaaa ctaataaaac ctggtatgtc acaaactcgc ccggtaaccg tc
#gtacgtgc  88080
ccctatgggc tctggtaaaa caacagcctt gcttgagtgg cttcaacacg cg
#ttaaaggc  88140
agatattagc gtactggttg tctcatgtcg ccgtagcttt acccagacgt tg
#attcaacg  88200
gtttaacgat gcaggcctct ccggattcgt aacatatttg acatccgaga ca
#tatattat  88260
gggttttaaa cgtttgattg tgcaacttga aagcctacac cgcgtatcca gc
#gaagctat  88320
cgacagctac gacgtattaa tactggatga ggtaatgtca gtgattggac aa
#ttatactc  88380
ccccacaatg agacgtcttt ccgcggttga tagcctatta tatcgtcttt ta
#aatcgctg  88440
ttctcaaatt atcgcgatgg atgctacagt aaactcgcag tttattgatt ta
#atctccgg  88500
attgcgtgga gatgaaaaca tacacacaat tgtgtgtaca tacgcgggag tt
#gggttctc  88560
cggaagaact tgcacgatcc tgcgtgatat gggcatcgac acgcttgtgc ga
#gtcattaa  88620
acgatctcct gaacacgagg atgtacgtac catacaccaa ctacgtggaa ca
#ttttttga  88680
cgaactagca ctacgattac aatgtgggca taacatctgt atattttcat ca
#actttatc  88740
gttttcggag ctagttgctc agttttgtgc aatatttaca gactctattc tt
#attttaaa  88800
ctcaactcgg cccctatgta atgtaaacga atggaaacat tttcgcgtgt tg
#gtgtacac  88860
taccgtcgtg accgttggat tgagttttga catggctcat tttcatagca tg
#tttgctta  88920
cataaagcca atgtcatatg ggccggatat ggtatcggtc taccagtcat ta
#gggcgtgt  88980
acgtttattg ctacttaatg aagttttgat gtacgtcgat ggctcaagga cc
#agatgcgg  89040
acccctgttc tcgccaatgt tactaaactt taccatcgca aataaatttc aa
#tggtttcc  89100
tacacacacc caaataacta acaaactgtg ctgtgcattt aggcaacgat gt
#gcaaatgc  89160
atttacacgc tcgaacaccc atctcttctc aagatttaaa tacaaacacc tt
#ttcgagag  89220
atgctctctt tggagtttag ccgatagcat taatatctta caaactcttt tg
#gcctctaa  89280
ccaaattttg gttgtattgg atggcatggg tccaataacg gacgtttccc ca
#gttcaatt  89340
ttgtgcattt atacacgatc tcagacatag cgctaacgcc gtagcttcct gt
#atgcgttc  89400
tcttagacag gacaatgaca gctgcttgac cgattttggc ccttccggat tt
#atggccga  89460
taacattacc gcgtttatgg aaaagtatct tatggagtca attaataccg aa
#gaacaaat  89520
taaagtattt aaagcccttg catgtccaat agaacagcct agactagtca at
#acggcaat  89580
attgggggcg tgtatacgaa tacctgaagc gttggaagca tttgacgtat tt
#caaaaaat  89640
atacacgcac tacgcttccg gttggtttcc cgtcctggac aaaaccgggg aa
#tttagcat  89700
cgcgactata actaccgccc caaatttaac cacacattgg gagctgtttc gc
#cgttgtgc  89760
ctatattgca aaaacactca agtggaatcc gtccaccgaa ggctgtgtaa ca
#caagtttt  89820
ggatacggac attaatacac ttttcaatca acacggggat tcgctggctc aa
#ctaatatt  89880
tgaggttatg cgctgtaacg ttactgacgc taagattata ttaaaccgcc cg
#gtttggcg  89940
aacaaccgga ttcttagatg gatgccataa tcaatgcttc cgtccaatcc ct
#acaaaaca  90000
cgaatataac attgctctat ttcgtttaat ttgggaacaa ttatttggcg cc
#cgcgtaac  90060
taaaagtacc cagacctttc cgggaagtac tcgtgtgaaa aacctaaaaa aa
#aaagatct  90120
agaaacttta cttgattcaa ttaacgtgga tcgttctgca tgtcgtacct ac
#cgccagtt  90180
gtataacctg cttatgagcc agcgccattc gttctctcaa cagcgttaca aa
#attactgc  90240
ccccgcttgg gcacgccacg tgtattttca agcacatcaa atgcacttgg cc
#ccgcatgc  90300
cgaagccatg ctacaattag cgctatcgga actgtccccg ggatcgtggc cg
#cggataaa  90360
cggggcggta aattttgaaa gtttataacc cgttaatacc atatatggac at
#ccataggg  90420
ggggttacat aaatactaag cctctgtaca acacaaaggg cctctaacaa tg
#cactgaac  90480
cacaaccaag ctatggacgc aacgcagatt accttggtta gagaaagcgg ac
#acatttgt  90540
gccgcaagca tatacacatc ctggacacag tccggacaat taacacagaa cg
#gtctttcc  90600
gtgttatact acttattatg caaaaactca tgtgggaaat acgtccctaa gt
#ttgccgaa  90660
attaccgtac aacaagagga tttatgtcgc tactccaggc atggggggag tg
#tttctgcg  90720
gcaacgtttg cgtctatctg cagggcggcg tcctcggctg cgttagacgc ct
#ggcccctt  90780
gaaccactgg gtaacgcaga cacctggcgt tgtctccatg gcactgccct gg
#ccacttta  90840
cggcgcgtat tagggtttaa atcgttttat tcgccagtaa cattcgagac tg
#atacgaat  90900
acaggtcttc tgttaaaaac aatccccgat gaacacgcgt tgaataatga ca
#acacgcca  90960
tctaccggag tattgagggc taattttccc gtggccattg atgtttcagc ag
#tcagcgca  91020
tgtaacgccc acacgcaagg tacgtcgcta gcctacgccc gcctgaccgc ac
#ttaaatct  91080
aacggtgaca cccagcaaca aacaccttta gacgtggagg taattacacc aa
#aggcctac  91140
atacgtcgga aatataagtc tacgttttcc ccccctatag agcgggaagg cc
#aaacctcc  91200
gatttgttta accttgaaga acgccgcttg gttcttagtg gcaatcgcgc aa
#ttgtggta  91260
agggtactct taccgtgtta ttttgactgt ttaacaacgg attccaccgt ta
#catcttcc  91320
ctttcaatat tagcaacata tagactgtgg tacgcggcgg cgtttggaaa ac
#ccggggtt  91380
gtccgtccaa tctttgcgta tttaggcccg gaactcaatc cgaagggtga ag
#acagagac  91440
tacttttgta ctgtcggatt tcccggatgg accactcttc ggacacaaac tc
#cagccgtc  91500
gaatctattc gcacggctac ggagatgtac atggaaacgg atgggttgtg gc
#cagtaacc  91560
ggtattcagg cctttcatta tctagccccc tggggacagc atcccccctt ac
#ctccgcgg  91620
gtgcaggatc ttattgggca aatccctcaa gatactggac atgcagatgc aa
#ctgtcaat  91680
tgggacgcgg gccggatatc taccgtcttc aaacagcctg tacaactaca ag
#atcgttgg  91740
atggcaaagt ttgatttcag cgcctttttt cccacgatat actgcgctat gt
#tccccatg  91800
cattttagat taggcaaaat cgtcctggct agaatgcgtc gaggaatggg gt
#gcctaaaa  91860
cccgcgttgg tgtctttttt tggggggtta cggcacatac tcccgagtat at
#acaaagct  91920
attattttta tagccaatga aattagcctt tgcgtcgaac aaacggcctt gg
#aacagggc  91980
tttgctatat gtacttatat aaaagatgga ttttggggaa tcttcaccga tt
#tacatacg  92040
cgcaatgtat gttcagatca ggcacgttgt tcggccttaa atttagcggc ca
#cctgcgaa  92100
agagcagtca cgggcttatt acgaattcaa ctaggtctta actttacacc cg
#ccatggaa  92160
ccggtactcc gggtcgaggg tgtgtacact cacgcattta cctggtgtac ca
#cgggaagc  92220
tggctgtgga atttacaaac aaacacgcct ccggatttag ttggcgtgcc at
#ggcgaagt  92280
caggcggcgc gagatttaaa ggagcgtctt tcaggactcc tatgtaccgc aa
#caaaaatt  92340
cgagaacgga tacaggaaaa ttgcatatgg gaccatgtcc tatacgacat at
#gggccgga  92400
caagttgtgg aggctgccag aaaaacatac gtcgattttt ttgaacatgt tt
#ttgatcgc  92460
cgttatactc cggtatactg gagtcttcag gagcaaaatt cggaaacaaa ag
#caataccg  92520
gcatcttatc tgacatacgg acacatgcaa gataaggatt ataaaccaag ac
#agataatt  92580
atggttcgta atcccaaccc acatggacct cctactgttg tttactggga at
#tgctacca  92640
tcgtgtgcct gtattccccc catagactgc gctgctcatc tcaagcccct ta
#tacacacg  92700
tttgtcacta ttattaacca tcttctagat gctcataatg atttttcaag tc
#catcattg  92760
aaatttactg acgatcccct tgcttcatat aacttcttgt ttttatgaca aa
#aaaacacg  92820
ccgcaacaac ccatccttaa aataaaaggt ttatttactt tacaacccgt gg
#tgaatttt  92880
tatacgtttc aaataactga acatttttcg gtgttaccat ggtgcgattt aa
#ccaccaaa  92940
aatatacgct cttctgatat tccgaatctc gtaaaggtcc atttaacaat cc
#cgggggta  93000
cttgcaccac accatctgga cagggggggg ttccgtgggg caggtcaaaa cg
#ctgaccca  93060
ccccacatga atatatagcc tttataatat tgggggccgt tccaggctga gg
#gttcagta  93120
acttaacaaa catataatgc ggcaatacgc gggtttttgt aaaggggttg tt
#atcaacga  93180
catacattag agtgtttaac aaccataaaa ctccctcata taaaaaccga cg
#catttttt  93240
ccaaaggtcc tatttgacac tcaacgcgtc taagatatac agacaattgt ac
#aaacagcg  93300
atggagatgc cccggagggc ccaatgcctt ccagatacat taaaataaca ca
#taaggtaa  93360
aatctaggac attatccggg cggaatagag tcatccgata gattaacagg cg
#cggaggca  93420
cccccaccgt atacacccta tcttcaaccg cagttaatac ggaaaaaata aa
#tccgcgga  93480
acgctggttg agtaacacac tccatgtagt aacgatcaca ggacacctca ct
#tgaatcac  93540
cattcaacac tactaaaacg gtctcttggt gttccggttt tacgcgcagt ga
#tacaacag  93600
agtttgccaa aaagcgtggc ttcaaaccgg ttacctcccg cgcctcgcat ac
#gaatcttg  93660
gtattgcttg tattctaaga tcttcgatca cgtcgctcac atccaacccc tc
#ttcggctc  93720
gtgttagtaa gttgtcgatc gttacgctgc aacctaaaat gctgggtata tt
#tattccgg  93780
acatcccatc ggccatcccc gcgcctccgg tttgctcgaa ttttatccag ta
#aggtcgaa  93840
tccgctgcat ttaccttgtg tacccgtaac ctctcagggg ggtgtccttt ca
#taaaatgg  93900
gataggtttt tatatccaac atgcatgtat tggttattta ttttattggg tt
#ccgggatt  93960
ctttcgtcat cttctgtagg gtcaggcaaa ccccaggaag gacttggtgt tc
#tccgtggg  94020
ccccgtttta ttacctctgc gcgaacctgc atttcatata atattcggat tt
#gggataaa  94080
taggactctg ttctcgcctt tttaaaaata gcctggcata actcttcctc tg
#acctatgt  94140
acctcgcttt gagttaccaa gaatcctaat cgggtggccc gtaatatgaa tg
#aaaaatac  94200
ggcgcaacta gtaatgagat tgacgcattt gaatatgata cagaaatttc ct
#ggccttga  94260
ttattgttta cccggtgaag cttaaaacag cgaacaagtt cctgtttcca ta
#gctcagac  94320
aaacgtttta tatcatctcc ataagggggg atataacgag attgaaaact at
#tggcaata  94380
tatgcatcat cccctattat gccggtaaga tctataacct cgtgatttaa at
#cggcaata  94440
cgtgtttctt ctgccattgt aatatgtgac cctttagatg gctttatttt ta
#ccctctct  94500
tcccgtaacc gtttcagctc tccttctttg aactggagcc tttcggtcag at
#cgctgttc  94560
acatccttga gaccctcaat ggttttgaat aaattattca cataaccctc ga
#gcatgccg  94620
ttgatactgt taaccaccga agttttaaac gcactttgaa cgtttgttgt tc
#cggacatt  94680
gcccccccgt taaaggattg gttggccttg ccaaaccccg gttgtgatgt gt
#ccaccgat  94740
ccacttcctt ccagaatgtg attgcccgtt tcttctagat aggaacgtac gg
#tttcggta  94800
atatctccaa catgtctcat gttttttaag ttaactatta gctttacaag tc
#tagacgcg  94860
gccgatccag cccgtgttgt atcgttctcg cccattatac gatcaaccgc ac
#gtgtgctg  94920
tgagatctat catcttcatt ccggcgacct attaacacgc gcaaaggggc tg
#tatttaaa  94980
acttggcaga cgcgagcatg ttcacgtaat gcataacagg ccaacacctc cc
#cagaaagc  95040
cgctgtaagg gtgagtcaaa tactacaccc tccccacata caacgggcgg cc
#acacgacc  95100
aaacactctc ccttcatgcc cgttacatca tcctttgcca taattaatct tc
#ggttataa  95160
ttataataaa gacgcgtcct atcataatcc ataatagcaa cattttgcat ac
#actcaact  95220
aggcttgtga caaccgccgc tcctctggcc aacgttgcat cggcaacttt ta
#acatctgg  95280
gacagttctg ccgcttgacc catatacgta tttaatggtg caggggttcc at
#tctgttct  95340
gatcgtacct ttcttacaac gggcacaata cctacacagg ctatccagtc ca
#cgtatttg  95400
gcaaaaccga cccttccatt taaaccactg gtatagagac aaccggttat tc
#cacgcaga  95460
aactcaagta acgatgactg taatgtttga cgccaggttt caaaaacctg at
#gtgcaagc  95520
cgtacggctt ctgattctcc acatagccca taacgttccg ctagagcccc gg
#catgcagg  95580
ttacattgtt ggatgtggtg ttcccaatct gctgctaggt cctcataccg ag
#ttgcatcc  95640
aacgcgttca tcaaaacggt tgcctgaact tggcgaatta cagtttccgt ag
#accgtaca  95700
gcgctatata tgccttgtcc atcggtatat ccaaagtcac cggctaggat tt
#ttcgaaac  95760
aacatacttt gcgtggttgg gtgtattaac atccagccat cttcctccgg aa
#atgtacaa  95820
aaccctatat ccggggcgta ctcattccag tatatatcga acatgttctt gt
#attggtca  95880
tttgggttac ttccattcaa gccctggtca atagaaacag aacttgctat cc
#ttttttct  95940
tcactaccgg aactgttatt aaaaagagac gttatttcgg ccattgaaaa cc
#acgatgaa  96000
aagatcaatt tctgtagaca gttcttcacc caaaaacgtt tttaatccag ag
#acgcccaa  96060
tggatttgat gacagtgtat atttaaactt cacctctatg catagcattc aa
#cctatcct  96120
ctcacggatt cgagaacttg ccgcaattac gattccaaaa gaacgtgttc cg
#cggttgtg  96180
ttggtttaaa cagttactcg aactgcaagc gcctcctgaa atgcagagga at
#gagctccc  96240
cttctccgtt tatttaatta gcggaaatgc cggctccgga aaaagcacgt gt
#atccaaac  96300
gcttaacgaa gctatcgatt gcattattac cggatccacc agggttgctg cc
#caaaatgt  96360
tcatgctaag ttatcaacgg cttatgcgag tcgtccgata aacacaatct tt
#catgaatt  96420
tggttttcgc ggaaatcaca ttcaggctca gctgggccgt tacgcatata ac
#tggactac  96480
gaccccccct tctattgagg acctgcaaaa aagagatatt gtatactact gg
#gaagtttt  96540
aattgatata acaaaacgag tgtttcaaat gggggacgac ggtcgcggag ga
#acatcgac  96600
atttaaaacc ctgtgggcaa ttgaacgttt gcttaataaa cctacaggct ca
#atgtccgg  96660
aaccgcgttt atcgcatgcg gttcccttcc ggcttttacc cggagcaacg tt
#attgttat  96720
tgatgaagca ggattgctag ggcgtcatat tctcacggcc gttgtttact gt
#tggtggct  96780
tttgaatgct atatatcaaa gccctcagta cataaacggt cgaaaaccgg tc
#atagtatg  96840
cgtcggttcg cccacccaaa ctgactcgtt agaatctcat tttcaacatg ac
#atgcagcg  96900
ttcacacgta actcctagtg aaaatatact cacgtatata atctgcaatc aa
#actctgcg  96960
tcaatatact aacatctcac ataactgggc aatctttatt aataacaaac ga
#tgtcaaga  97020
ggacgatttt ggaaatcttt taaaaacgct tgagtacggg ctacctatta cc
#gaagcaca  97080
tgcgcgtctg gtcgatacat ttgttgtacc tgcatcctat attaacaatc ct
#gctaatct  97140
tcccggatgg acgcgtctgt attcgtcgca taaggaggtg agcgcgtata tg
#agtaagtt  97200
acacgcgcat ttaaaactat cgaaaaatga ccatttttct gtgtttgcct ta
#ccgactta  97260
tacattcatc cggctaacgg catttgatga ataccgcaaa ttaacgggac aa
#cccggact  97320
ttctgttgaa cattggatac gggcaaactc cggtcgtttg cacaattatt cc
#caaagccg  97380
agatcatgac atgggaacag ttaaatacga aacacattca aatcgcgact ta
#attgtagc  97440
ccgtacagac atcacttacg tgctaaatag tctcgtagtt gtaaccacaa ga
#ctacgtaa  97500
gttagttatt ggattcagtg gtacatttca atcgtttgca aaggttttac gt
#gacgactc  97560
ctttgtgaag gctcgaggag agacatccat cgaatatgct taccggtttc tg
#tcaaacct  97620
aatctttgga ggcttgatta acttttacaa ttttttgtta aataaaaacc ta
#catcccga  97680
taaggtatcg ttagcataca aacggttagc tgccttaacc ctggagttat tg
#tctggaac  97740
aaacaaagcc cccttacacg aagcagcggt taatggggcg ggtgccggga tt
#gactgtga  97800
tggtgcagct acttctgccg ataaagcctt ctgctttacc aaagcccccg ag
#tccaaagt  97860
aacggcctcc atacccgaag acccggatga tgtaattttt acggcactta ac
#gacgaggt  97920
tattgacttg gtatactgcc agtacgaatt ttcctatccc aaatcatcca at
#gaggtcca  97980
tgctcagttt ctgttaatga aagctattta cgatggtcga tatgccatat ta
#gcagagct  98040
tttcgaaagc agctttacaa ccgccccctt tagcgcgtat gtcgataatg tt
#aatttcaa  98100
cggaagcgag cttttgatcg gcaatgtgcg gggggggctg ttatctttgg ca
#ttacaaac  98160
agatacgtat acccttttgg ggtatacttt tgcacccgtg ccagtctttg ta
#gaggaact  98220
gacccgaaaa aagctgtacc gcgaaactac cgaaatgtta tatgctctac ac
#gtacctct  98280
tatggtctta caggatcaac atgggtttgt gtccatcgta aacgctaacg ta
#tgtgaatt  98340
taccgagtct atagaggatg cagaattggc aatggccacc acggtggact at
#ggccttag  98400
ttctaaacta gccatgacaa ttgcacgctc acagggtctg agtttagaga ag
#gtagctat  98460
ctgttttacg gcggataaac tgcgcctaaa tagtgtgtat gttgccatgt cg
#cgtacggt  98520
ctcctctagg ttcttaaaaa tgaatctaaa ccctctacgg gaacgatatg aa
#aaatccgc  98580
agaaattagc gatcacattc ttgccgctct acgtgatccc aacgtacacg tt
#gtgtatta  98640
aagcattgta taaaaacacg catgcgggct tgctgttctc atttctaggt tt
#tgtcttaa  98700
atacacccgc catgagcatc tctggacccc caacgacgtt tattttatat ag
#gttacatg  98760
gggttaggcg ggttcttcac tggactttac cggatcatga acaaacactc ta
#cgcattta  98820
cgggtgggtc aagatcaatg gcggtgaaga cggacgctcg atgtgataca at
#gagcggtg  98880
gtatgatcgt ccttcaacac acccatacag tgaccctgct aaccatagac tg
#ttctactg  98940
acttttcatc atacgcattt acgcaccggg atttccactt acaggacaaa cc
#ccacgcaa  99000
catttgcgat gccgtttatg tcctgggtcg gttctgaccc aacatctcag ct
#gtacagta  99060
atgtgggggg ggtactatcc gtaataacgg aagatgacct atccatgtgt at
#ctcaattg  99120
ttatatacgg tttacgggta aacagacctg acgatcagac cacaccaaca cc
#aaccccgc  99180
accagtatac atcgcaaagg cggcagcctg aaaccaactg tccttcttca cc
#acaaccgg  99240
cctttttcac atcagacgac gacgttcttt cgttaatatt acgggacgcc gc
#aaacgcgt  99300
aaagacagat tcaagactaa catttatccc aactgattac atttcatacg cg
#aataaacg  99360
acacaaaaaa tttatattta acggctttta atttgaagac acctatcctc tt
#aacgttga  99420
tgagccttgc aggttgggtg ccgcgcttca ccggtattat acataaccga tt
#taccgtgt  99480
ttacggcagt ctgaccattt accagtgtat gtctgtaata cgacgttgtt gt
#gtcccgac  99540
aaaattaact cgcgtacaaa tttctgatgt tcccccggcg tggcaacgct gg
#catttcca  99600
aacacattac gttctcgtac gtccatgacc gctattttca gtattaattg gt
#tggtcggt  99660
caaagtattt tccttatgta aaaggacacg atctaaagcc gtaaactcat ac
#acaaacac  99720
tggtaccaac ggacgcgatt ttccgtccgt tgagcgggtg taatatcggc ga
#ggtcttct  99780
tgcacgaata ctctcgtaca gtaggtttct gacacggggt gcatgggttt tt
#tgacacaa  99840
cacaaacatt tgcaggctct tatgactgga tggattgaat ttatttttag at
#agggtcac  99900
gtgtttttgt cgtgacacgc ctcgaccaga aaaggctgcg gttttcgtac ac
#gcgaccgt  99960
tatttcacag gcgttcataa ccaagctgcg gcggatggtg tcggttaatt gt
#ctccgccc 100020
aagttcgtca atagatgata ccatgaacaa cgtatcaaat ggtacatagt cg
#tctttggt 100080
tttctcaata cagcccgcgt gcccaatcgg aaatttttca tttgcatcaa cg
#ctattttc 100140
tgtaaaatcg ttctgaacac tgtgttggct ggctacctgt ttaaaatttg gg
#atcgaaca 100200
cggtccacga tgcaatcccc aaccccattg aagcaatgcc gtcggtacgg aa
#ggaggcaa 100260
ctccgaaaac attatggtac gcaagagggt cgattggagt gttatataac ac
#tccaatcg 100320
atctcgggtt cgcctttacg cgtaaaatac tcattggctt gaacgaaatg tc
#gacaattc 100380
cgaaatggaa cacgggacaa tggcgacgga tgcgcgtgtg ttagcaccag at
#gacatctt 100440
gaattcggtt gggttgtctt ctgtgcatgc gcaccccaca gcataaaaac ta
#accctgta 100500
cggttctcgc ataacctctg tagcacgcgt tgcaccagcc gcccccagcc ta
#agtataca 100560
tgcgaccccg gagtcccgcg acgaaccgta agcgtggtat tcagcaataa ca
#ccccctgc 100620
cttgcccaac tctccaggca tccgtgagtg ggcggagtca tatttgggta tg
#attccatg 100680
agggccgcaa aaatattttt aagactagac ggtggtgtta tgccacgttt ta
#cactaaac 100740
gctagcccat gtgcatgtcc cgcggtaggg tatggatctt gaccaataat ta
#caacgcga 100800
atgctctggg gtccgcaaaa tcgcgtccat gcaaaaatat cgcctgtaga tg
#gaagtatt 100860
tcttcccctg aatttaaaag acgattgtat tctaaaaaaa tacctttcgc gt
#acggctct 100920
ttaagttcgt ccgacaacag gtcataccac tcaggggaaa tgttaaactt gc
#tgaaaact 100980
tcaaccgaat ccagttgcga agagacgggg gtgaacgttt ccgtgtcgta at
#gatgtgac 101040
atgttattta acttgaaggt tggggggtct agcttaaccc ccaaaggcag cc
#cgcggggt 101100
cgcttgcggg tttttttggt aaccggatgg gccaaaacat aaatgtcctt tg
#aatccgat 101160
agtttcattt cattggcata cgcgttggaa caaacggtcg gctccccaga ca
#catccatt 101220
ttccgggata tttgtggaag atggagtaga gtctacccat acaccggaaa gg
#gcatccaa 101280
caaagcatcg cgtatgtccc cgcttttatg ttcttcacca acagattgtg cc
#agcccctt 101340
taaggtgacg tatggatttg tccagtacgc catttgtttg tctttaaacc aa
#agtataac 101400
ttccggtact ggacattttg tcttaaccac gattcccgat agcgcctcgc tg
#aggtttga 101460
taccgggggt gccgcatagt cccacgcctc atataccgat gacacgcacg gt
#tccgttat 101520
aatcaaactc acatccgata gcggtttggc tccaaaaaac aacggagtgt cg
#tcttggag 101580
atgaagacaa tacgcgattg tgatagtttt taaaaaaact atctgcagta ac
#catttatg 101640
tgatgccatg acgcttgtgt tttcccttca ctacgacgtt gtcgtatcct tt
#gaaaaact 101700
tgaccactct aatggaagca tggacaagta tgagttttat atatacagtt gg
#cctttagt 101760
taaactcttg gtgtcatatc tcattttcct aaaaagggcg atcttaatat gt
#caaacgtc 101820
acggcgtgcc gacaaagcga atttccatgc aagatttgga tgtagtattt at
#acacccaa 101880
tcacatgtca cgtattaagc tttacagtcc cccgttatct gatataatca ct
#tttcttaa 101940
cacgtcatcg ggaaaacaga tgtttatatt atacctctcg cggtcattta cg
#gcaaatac 102000
ttagaccgtt ttcaagcgga ctgaaaacgc tcaaattgcc ttttggaggc ct
#gcccaacg 102060
gccattatcc cttggatcta agattgattt gcggtaacgt ttgccaatca ag
#ctttaaaa 102120
acgtacccca aacttaaaac gctcaaattg ccttttggag gcctgcccaa cg
#gccattat 102180
cccttggatc tgagattgat ttacggtaac gtttgccaaa cccacgcatt tc
#agtttaaa 102240
tatttctaag cattcttagt gcgtacttgg cagcgtgctt aaaatatcaa cc
#aatatcca 102300
ttatgctaca cgtttccttc tatccgtttc aatccattaa aagtccatta ac
#aaaaatga 102360
tgcatcatac ctaattcacc taaaaacctg actcattgca gcagcgtttc ct
#ccttgcag 102420
actatccagt tggcatttta aacgggtccg gctgcctaaa ccgaaaacac cg
#ttgccttt 102480
actgtaagta caaaactaaa atttatattt gcgtgcgtat tttgtaacat at
#atgccttt 102540
tatccccccg caagtttgct ttaccctcgc cttcaccacc cccgccacct tc
#cggccatt 102600
ttaataactt taattgctat aagacatacc caaaccggat gatttttgcc gc
#tggaaaaa 102660
cagcttctaa ttttcccgtc tcaactcggc cttggttgca tctccaagta ta
#cctttagt 102720
ttgctcccgt agaggtgtat aaatacaaac ggtgacaagt attgagcgta at
#ctcaaatt 102780
tttgtaattt agggcggagc gcttacgaca gcacatgcgt actgttagac tg
#ttatgttt 102840
attgtatttg cagagcagga tgccccggtt actccgagac cggattgcgg gc
#attccgaa 102900
tcgtgtacgg acttaccagg gggcagtatt tacaccttgg gttccagata ta
#ccaaccct 102960
tacgaccaat agcaacactc aggtattttt aaaatgcacg tttaatgatc at
#aatttaca 103020
tacagttggt aataaagcag actgtggatg tttaaggcat ttccttcccc ct
#cccaacaa 103080
actaggactt cttcatcttg tttggaatac ctttacccgc tttaccggca ga
#gctttttt 103140
tggtaaggtg tttcagtgaa cctgatgttg atccggaggt ggagggggta tt
#ggactccc 103200
cctgtggaga ggcaactttg cgggttttac ttcccttaca tgccgaatca ga
#ctcagatg 103260
tcaggtctat tgttaagcat cgtttaacgt ctctgccggt atgaaataaa cg
#gcgcttag 103320
caccccttgc gcttcccggt ttaatccccg gtaacacaga aaaaagcctg ac
#tttttggg 103380
gtgtatttac caatcgggta tccctttcat cgccacgaga ggtctccccg gt
#tgaggtgg 103440
tttctggtct tacaattgga cctgtaatta gttggatggc tgtatctttc ca
#ggtccagg 103500
tttgcatggt taggcgggtt ggatcggtac atcgatccaa caagaataac at
#gtttgtta 103560
caaacggtcc tgttgaatca tgcaaaagac aacgcaggga tgtttttaat cc
#cgcctcat 103620
cacgcccgta aatacctata tagtttaata tcaacatttt tgtaggctct ac
#aatttcgg 103680
gttgatacag ttccgcaagt tgatcatcaa gccatccgag taaaggttgc at
#gtaacacg 103740
ggaatctcgc gtttccctct gttcctctat ccgtggctcg aaaaggcagt ct
#gtccatgg 103800
ttcgtgggtc ttgattaatt cccacagata ctggacgatc acggtagtcc tg
#ccccccgg 103860
tccggggttg ctgtgcagat tcaatcgagc catacaccac cggggtcgcc ga
#tcgaacag 103920
caggttggtc tttaaaaaat accttccgta aaaatgatgc ggtagagcat gt
#tttggtta 103980
caccagggct cgagtctcgg gtcggtggtt gtatagaatc ctgttgagag tc
#acttggtg 104040
actctgctgt gggctctcta gccgacgatt gaaggggccc agggtttggt ga
#ttgaatgg 104100
gctcccgact cgatcttgat gttggctgtt ggatggactc ccgactcggt cc
#tgggcttg 104160
gtggcagaag atctatgaca tctcccggta ggatgtcgat ggaatcttca aa
#tgacggct 104220
cagaaaaacc atcgtcgtcg gatgggtgca cttcatattc cttgtaactt gt
#atcactta 104280
cgatcttatg caggatggat tgcactggac accggcagag aggacactgg ac
#gctggtgg 104340
aggtccatgc ccgaatacaa acaaagcaga agtcgtgcaa acacggcatg gt
#ttttccga 104400
gatcggaaac ggtgctcatg catatggtgc aggtattatc cgaagcgtcg ga
#ggtgccgc 104460
taccgcccgc taatatggta tccatggtaa caactggctg tattctaatg tc
#cgggcatc 104520
caaacacgta gcagaactgc catgcgttct aaattgtgag ttgtggcgag ta
#cattttta 104580
taattggtac caacgaagac acacccctat atccctccac ccatttcttt ta
#agtcccac 104640
ccactaaaac gtgggtataa aatgtgtatt ggggtaggcg gacagtccca ac
#aaacaggg 104700
aagttgattg gtataacctt gggccgggta tacagctaag tgacatttta ga
#ttctgtct 104760
ttatttagat aaagagcgat acgaagacat ttctccaccc ccctgtaata cc
#cgtaaata 104820
aaggtaagtc cacaaacaaa agcactgtat ataggaagtc gggtgtattg gg
#acagttac 104880
tccattagag gcgtacaaac aatactggga tagggtaatg caagtccccc cc
#gatggtcg 104940
ccccgcaaac gcgcggggag gtggggtcgc tttttttttt ctctctcgag gg
#ggccgcga 105000
gagggctggc ctcctctccc ggggtccgcc gggcgcccag aaaccggggg gg
#ggttattt 105060
tcgggggggg gtccgaccag cccgcccgtc gcccgcccgc acagacagac ag
#acactttt 105120
ttcataaaaa ccgttccgct tttattaaca acaaacagtc cgcgcgccag tg
#gcgctcac 105180
gagaaaagga ggggactccg tcacccccga ctctgcgggg ggctcctccc cc
#cgcgccct 105240
ccccacacat cgtcctcgtc ctcggaggac gaggacgagg acaacagctc ca
#ccttgacc 105300
gccgggcgca aacccacccg gcggtctcgc agcacacccg gggccaccga ca
#cgatgctc 105360
accccaaagg atgaccccgg tgcgtccccg tcgtccccgc ccccctcctc gc
#tgtcccac 105420
gcgtcttcac accccacctc ccaatcgtcc agctccaaag cgtgttctct gt
#cgtctgcg 105480
gtgcgccgct gtcgccccgc ctgggtttct gacggccgtt ccgagccccc gt
#ggtgtccg 105540
aacacgaacc gtgttccgtc gctcccctcc aacaccgtct ccgcggcccc aa
#aaccgggc 105600
ggccacatta ctctgggaat cggggggagg gcattccgag cctcgtccgc cg
#acgcatac 105660
agcgccaccg accgaccggc cacgggtgga agcacgagtg gttctgcggc ag
#ggtcgggt 105720
tccagcaggg cgtggcggca aaacaccctc gcccaggtgg gtacgtcgcc gg
#cctccggc 105780
ccggcggccc ccggtctccg tccctcggga aggaagacgg gtcgaagcgc gg
#cacccagg 105840
ccccatcggt ttgctgcgcg gtggctatgt gccgcctcgt ccacaaagtc gg
#ctgccccg 105900
agccccagac cccgagactg tcgcgcgagg tccttgcaac cgtcaaaacc cg
#gcagcacg 105960
tactgccggt attcacgggg cgacaggggg acgcgggtct tggggcccgc gc
#gggtacac 106020
acggtgtatg cgacgttccc accgcggcac aaacacaggg gttgttcgcc cg
#ggtacagg 106080
ttggcaaacg cagtctcgat acgagcaaaa ctcgctggcc caaaggtgcg cg
#acgatgca 106140
aacacggccc gggcgagtcc ttctgtgacc gccgagtctg gccatcggac ga
#cggcctgg 106200
gcgtccggtc gcgccggggc ccggacgtac acgtgatact gagacaaagc gg
#gtccatcc 106260
ctgggccacc tctcgagggc caccgcgtcc aacaccagca accggcgccg gg
#cagaggcc 106320
aaccgcgagc ctagatactc gacggccccg gcaaaggcca ggtctcgggt cg
#acagtaat 106380
aaaacgcccc gggcgttcaa agcggacacg tccggcgggc cggtccagtt cc
#cggcccag 106440
gcatgagtgc tcggcaggca caaccggtta ctcagggctg ccaggaccac ag
#acagtccc 106500
cctcgggatg gactccatga cggtcccgga tctgtcgcga gggtgctctc ga
#gggggccg 106560
ttgatgtcct ctccgggcaa cggatcgtag atgatcagaa gcctcacatc ct
#ccgggtct 106620
gggatctgcc gcatccaggc gcacctccgt cgcagcgcct ccactccgct gg
#gtggacca 106680
aaccgtcggt ctcctccgcc cggacgccga gcggcgattt ccgccaaggc gc
#cgggatca 106740
aagcttagcg cagggcgcca ggccgtggga aacaatgggt cgtcgaccag ac
#gggcgatg 106800
gtttcggggg tacagtacgc cttgcgagcc tggtccgacg ggaccggggt at
#gcagggcc 106860
ccccggggaa tacgccgaaa tcccccgttt ggggccggtc cgtcaagtgg ca
#tcgttatt 106920
acggcggggg gatccaccac agggcccgag gtgatggtca cgggctcgga ta
#cccgcctc 106980
ttggccttgg aaaccacatg atcgtctgca acccgggcgt ccgcgacggg tg
#tctcccta 107040
atcttgtcga ggaggcttct gctctcgact ggctgggact tgcgcttgcg cg
#gagttcgt 107100
aaacgatcat ccggtggaca cacagaaaga gagcgtgcgg cggccgacgg ct
#gagggtcg 107160
ggagcctgtg tggccggggt tgttggagaa gggtgaccgc gggagatccg cg
#ccgccgga 107220
ctggagcccg ttgcctcggg gtatgccatg ctggcaaagg ctctgcggag ac
#tctgtagg 107280
ataaagtgtt tttgggcccg gtcgtatcga cggctcatag ccacggccgc gg
#ccgcgtgg 107340
gggagagccc agagggcctc ccccgtggcc atggcttcgc ctacatgcgg aa
#cgggagac 107400
gctacgctcc ccgtaacggc ggtacccgcc cgtcccggtg gcaacagctt tt
#ggtagaac 107460
tggttcaggg ccgagttgac accggtcagc ttggggttct ggagccatgc ta
#tagggtct 107520
ctgtctggac agtagatcag gttaatcagc gcgcggtact gtctagccgg at
#ctcccaac 107580
tccggcacgt aaagcggcac gggttccgtt gaggcctcgt aacgagcccg cg
#ccgctctc 107640
acagcctcat cctcccagtg accctctctg gtctccccgg acggtccaaa cc
#gcaccctg 107700
ttggatggga ggggtgccga tccgggccaa gggcttccgt cgggcatcat ga
#gcggcccc 107760
gacaccgggg gaattatcgg ggttctggat cgcggcaggg aaaatgattt ct
#gtctctgg 107820
cgccccggtt cccccgcaag acgtttggtc ttacgaatcc tcggatcggg ac
#cgctgatg 107880
gatcgatatc ccggttggat attttgtttc gtcgacccac catcatttga gt
#ccgaatca 107940
tccgaatttg acggggaagg ggcgtgttcg cgtccggacc tgctgcctgt ag
#tttcactt 108000
cccaccgaaa cgcgccgggg ttcatcgtct tcatcctccg atgacgatcc cc
#acgacgag 108060
gaagaggatg aagacgaaac aaactcacga ctctttggct ttttctccac tg
#ggctgtca 108120
tcctcaatcg ggtctggtgc gtgggatctt cccggcaggg ccaaaaacgc tc
#taggtttg 108180
ccccccgacg aacgtccagg gacgcgaggt gttatacccc gggcatcatg tt
#tccttggg 108240
cgggtatcat cggtctcaaa cggcaggtcc gcctttgccc ccttagcggg aa
#cgctgtcc 108300
gaaaggacgt ggtacaattg ctcaaccggg ccgggtacag gtccaccggg tt
#tccgcgcc 108360
gggagtggga ccttaacctt caaagtcttt ttcttcgggc tctttccctg ag
#cgggccgt 108420
tgagttttct ggagaactac tccgtccccc gatgcatgcg catgacccgc tt
#gctcatcg 108480
cccggctttt tacccgagat ggactgagtt tgtctgtctc gatggaccac cg
#acggcaaa 108540
cctggtgaat ttcctctcgt cgtttgtcgg ggtatagacc gctggtcttc cc
#gttgatcg 108600
ttcccggcgg cgtctccaac aggagacgcg ggggatacag gggagaaggc ct
#gcgggaac 108660
ggaggggtcg tacctctgcc cgtttcccca tcgttcatcg gtggttttgg ag
#acctagca 108720
agcttcgttc cgagagagac tgtctcaagg gagcgatcgg ctcctgttgg tt
#ctcgcgcg 108780
ccggcctccg agaatcgggt gtggaagacc tcggccagcg ggattacagg cg
#agcccatt 108840
agatcctgac cgtcctcgca tacgtagtcg tcttgtgtta gctcttcgcc aa
#catcttcc 108900
gttctgggtt ctggttgaag tcccgatacg gagggaattg aaacgatctc gt
#gttcccgt 108960
cccaccatga ccccgttctc tccaaatagt agatcgtcag gctgactcga gg
#tgaccacc 109020
cgggccctgt gttcggcggc cgccgcggcc gcgtccaaca ggtccattaa ct
#ccaaagta 109080
tcaggcgacc ccgcgcgttg gggtgtagag cgctgcatcg gcggcgtatc ca
#tcgcactg 109140
gggtgaattt agacgtaccc gagttttcca aacgctctcg cagccttcaa ag
#gattgcga 109200
ttgcggttgg tgagggagtt ccaacagtac ttaaaacgtg ttgtgccccc cc
#ctcgaccg 109260
catatttcct ccccgtgtcg tcaccgtgta aatattctta atgataagac ga
#tgtagtga 109320
ttggacgaga ctcgaggcgg gaagttcatg gaccatagta tgcgtttaag ga
#gagaccgc 109380
tggttggcga tgtacgcccg gtgtctattt ccgcatacct tacaacatca ta
#acaaggga 109440
taccagacat gtgaatttca tttacatatg tttaaataac aaccaatcat cg
#tgtgtcta 109500
cagacgatat ataatataca taaacacaat tggggttgtc tcacatgcaa aa
#catcttat 109560
ataacacggg ttgtttccac ccatccggca tctagttaat caaatgcacg tc
#gacggtgt 109620
gtttgggtcc ctctccgtcg tcattacgtt cgcgcaatca acaagcgtat ac
#accaccac 109680
ccctcccaac gattatgtca ggcggcacga agcccgcgat aacccataaa at
#acacacgg 109740
ggttgtggtg ttcacgtaac cccccgccga tggggagggg gcgcggtacc cc
#gccgatgg 109800
ggagggggcg cggtaccccg ccgatgggga gggggcgcgg taccccgccg at
#ggggaggg 109860
ggcgcggtac cccgccgatg gggagggggc gcggtacccc gccgatgttt at
#aaccataa 109920
ttctctaaac cgttgtagaa aatcacaaaa aaatttattc aaaaacaagt cg
#aagaactt 109980
catatctgag gcatgtaaac ccgttcgcac ttcctggggt ggaatggggt gg
#ggtggggg 110040
ggtgaaaaag ggggggggtt aaattgggcg tccgcatgtc tgtggtgtac gc
#caatcgga 110100
tacactcttt tgatctgcat tcgcacttcc cgttttttca ctgtatgggt tt
#tcatgttt 110160
tggcatgtgt ccaaccaccg ttcgcacttt ctttctatat atatatatat at
#atatatat 110220
atatatagag aaagagagag agtttcttgt tcgcgcgtgt tcccgcgatg tc
#gcggtttt 110280
atggggtgtg ggcgggcttt tcacagaata tatatattcc aaatggagcg gc
#aggctttt 110340
taaaatcgat ttgacgtgat aaaaaaaaac acacggggcc cccccctttt tt
#tggtgtta 110400
taaaggcaac ccaatcgaag gtctcccgcc ccggaatccc ccattgccat tt
#tacccaag 110460
tagccttatt catagatgta aacgtttggg tgtgtgtttt gttgtgcagg gt
#tcgtccga 110520
ttcataacgc gacagcgtcg agtcggtttt aagggaaaag gttactacgg cc
#ccaaggac 110580
atgttttgca cctcaccggc tacgcggggc gactcgtccg agtcaaaacc cg
#gggcatcg 110640
gttgatgtta acggaaagat ggaatatgga tctgcaccag gacccctgaa cg
#gccgggat 110700
acgtcgcggg gccccggcgc gttttgtact ccgggttggg agatccaccc gg
#ccaggctc 110760
gttgaggaca tcaaccgtgt ttttttatgt attgcacagt cgtcgggacg cg
#tcacgcga 110820
gattcacgaa gattgcggcg catatgcctc gacttttatc taatgggtcg ca
#ccagacag 110880
cgtcccacgt tagcgtgctg ggaggaattg ttacagcttc aacccaccca ga
#cgcagtgc 110940
ttacgcgcta ctttaatgga agtgtcccat cgaccccctc ggggggaaga cg
#ggttcatt 111000
gaggcgccga atgttccttt gcataggagc gcactggaat gtgacgtatc tg
#atgatggt 111060
ggtgaagacg atagcgacga tgatgggtct acgccatcgg atgtaattga at
#ttcgggat 111120
tccgacgcgg aatcatcgga cggggaagac tttatagtgg aagaagaatc ag
#aggagagc 111180
accgattctt gtgaaccaga cggggtaccc ggcgattgtt atcgagacgg gg
#atgggtgc 111240
aacaccccgt ccccaaagag accccagcgt gccatcgagc gatacgcggg tg
#cagaaacc 111300
gcggaatata cagccgcgaa agcgctcacc gcgttgggcg aggggggtgt ag
#attggaag 111360
cgacgtcgac acgaagcccc gcgccggcat gatataccgc ccccccatgg cg
#tgtagtct 111420
ttataaataa atacaatggt ttggctcgtg tctttttttg atgtctgtct gt
#gggggagt 111480
ggggtgttgt ggatattaga gggtagaggg tgctggtttg aacgtctcca tt
#aacccacg 111540
gggtccccac acgggccgtg tggtatgaat ctctgcggat cccgcggtga gc
#acccgggc 111600
ggtgaatatg ccggacttta ctgcacacga cacgataccc ccgcgcacca gg
#ctctcatg 111660
aacgacgccg aacggtactt cgccgccgcg ctatgcgcca tatctaccga gg
#cctacgag 111720
gcttttatac acagcccctc cgagagaccg tgcgcgagtt tgtgggggag gg
#caaaggac 111780
gccttcggac ggatgtgcgg ggagctcgca gcggatagac aacgtccacc ct
#cggttccg 111840
ccgatccgca gagcggtgtt atcgttatta cgcgagcaat gcatgccgga tc
#cacaatcg 111900
catctggagc tcagcgagcg gctgatattg atggcatatt ggtgctgttt gg
#gacacgcc 111960
ggacttccga ctattggatt gtcgcccgat aataaatgca tccgcgccga at
#tatatgac 112020
cgccccgggg gaatttgtca caggcttttt gacgcgtacc tgggctgcgg gt
#cccttgga 112080
gtcccaagaa cctacgagag atcctgacac cccatccctt tatatagaaa aa
#aaaaataa 112140
atttaaaaca tacaccggat aaaagcgtac tgttttttat ttaaatttac ac
#gctcggcg 112200
ttgccccggt tcggtgatca ccgggtctta tctatataca ccgtgtaact cg
#aacccccg 112260
tgactccctc caatcgcgtt accaaactct tcttccgtat ccgtagattc cg
#agtcctcg 112320
aaatcgtcca cttatccaac aaattgtgac gttatatatc ccaaggcaaa gg
#ccgctccc 112380
gtcatagcaa atacaaagac aattattagc gtaatataac agaatttttt ac
#gatgatat 112440
attttatgtt gatattttcc aattcgacgc aaaaattcat ctgccgtttc at
#tttcgcta 112500
tcactataat aacacttttc agccgaacgg ctcggttgta tggctgttat cg
#ttgtatta 112560
tttggttgcg ctcgcggggt taccaccgct tccatcagta aggccacggc ct
#caccctcc 112620
atggtgtttt gtccggccat agaaatccag attgtaaggc cagcaggcta gt
#ttaaaagt 112680
gtttaatacc acaccttttg atatttatat acatgcaaga ttctagatta tt
#catcaata 112740
ggtcgtttaa agcgcgtttt cataaacgtt gtcagctata ccgacattct ca
#caaagagg 112800
taaagttacc ttacgttatt attaaataaa acatgtagac attattaata at
#cctaggaa 112860
caatcaaatc catatttgta agttatgttt aacccctccc ctttttgtca tt
#atctccgc 112920
cctcttataa tcggatcact ttataagtgt gtcggtgagt atattttgta ca
#gttgttgg 112980
acaacaggtt tttggttcat taacactatc aacataagtc ggggtataca ag
#tataatga 113040
acgacgttga tgcaacagac acctttgttg gacaaggaaa gttccgtggc gc
#catctcaa 113100
catcaccgtc acatattatg caaacatgtg ggtttataca acagatgttt cc
#agttgaaa 113160
tgtcgcccgg catagaatct gaggatgatc ccaattatga cgttaacatg ga
#tatacagt 113220
cttttaatat atttgatggt gtacacgaaa ctgaagccga agcctctgtg gc
#attgtgcg 113280
cagaagcacg cgttggaatt aataaagcgg gatttgtaat attaaaaacg tt
#tacaccag 113340
gggcggaagg ttttgcgttt gcgtgtatgg acagtaaaac atgtgaacat gt
#ggtcatta 113400
aagcgggtca acgtcaagga acggccaccg aggcaaccgt gttaagagcg tt
#aacccacc 113460
catccgttgt acagcttaaa ggaacgttta cgtataacaa aatgacatgt ct
#tatattac 113520
cacgttaccg aacagattta tactgctatc tagctgcaaa gcgcaacctc cc
#catatgtg 113580
acattttagc aattcagcga tctgtattac gcgcgttaca gtatcttcat aa
#taacagta 113640
ttattcaccg tgatataaaa tctgaaaata tatttattaa ccacccaggt ga
#tgtttgtg 113700
tgggagactt tggagcagcg tgtttccccg tggatattaa tgccaacagg ta
#ttatggct 113760
gggctggaac aatcgccaca aactctcctg agttattggc tagagatcca ta
#tggacctg 113820
ccgtggacat atggagtgcc gggattgtat tatttgaaat ggctacagga ca
#gaactcgt 113880
tatttgaacg agacggttta gatggcaatt gtgacagtga gcgtcaaatt aa
#acttatta 113940
tacgacgatc tggaactcat cccaatgaat ttcccattaa ccctacatca aa
#tcttcgtc 114000
gacaatacat tggtttggca aaacggtctt ctcgaaaacc cggatccagg cc
#attgtgga 114060
caaatctata tgagttgcca attgatttgg agtatttgat atgtaagatg tt
#atcgtttg 114120
acgcacgtca tcgaccatca gcagaggtgt tgcttaacca ctctgttttc ca
#aactcttc 114180
ccgatccata tccaaatcca atggaagttg gagattaaaa ttcattaagc ct
#gttaataa 114240
aatattgtat aaattgtgtt tataacgtat aacccgttaa ggcaaatagg gt
#acaaacgc 114300
gcaatgtttt gaaatactaa tataaataac ataaccaata gaaacttaat ac
#agagtcac 114360
gccccattac aacaaggata aaacacggga tcattttctt aacattgtag ta
#gcgctgaa 114420
aagcgtcccc tcccccggct cacagagctg ctcttcggtg tagttgggta ta
#ctggtgcg 114480
cctcatttaa tcgcgatgtt tttaatccaa tgtttgatat cggccgttat at
#tttacata 114540
caagtgacca acgctttgat cttcaagggc gaccacgtga gcttgcaagt ta
#acagcagt 114600
ctcacgtcta tccttattcc catgcaaaat gataattata cagagataaa ag
#gacagctt 114660
gtctttattg gagagcaact acctaccggg acaaactata gcggaacact gg
#aactgtta 114720
tacgcggata cggtggcgtt ttgtttccgg tcagtacaag taataagata cg
#acggatgt 114780
ccccggatta gaacgagcgc ttttatttcg tgtaggtaca aacattcgtg gc
#attatggt 114840
aactcaacgg atcggatatc aacagagccg gatgctggtg taatgttgaa aa
#ttaccaaa 114900
ccgggaataa atgatgctgg tgtgtatgta cttcttgttc ggttagacca ta
#gcagatcc 114960
accgatggtt tcattcttgg tgtaaatgta tatacagcgg gctcgcatca ca
#acattcac 115020
ggggttatct acacttctcc gtctctacag aatggatatt ctacaagagc cc
#tttttcaa 115080
caagctcgtt tgtgtgattt acccgcgaca cccaaagggt ccggtacctc cc
#tgtttcaa 115140
catatgcttg atcttcgtgc cggtaaatcg ttagaggata acccttggtt ac
#atgaggac 115200
gttgttacga cagaaactaa gtccgttgtt aaggagggga tagaaaatca cg
#tatatcca 115260
acggatatgt ccacgttacc cgaaaagtcc cttaatgatc ctccagaaaa tc
#tacttata 115320
attattccta tagtagcgtc tgtcatgatc ctcaccgcca tggttattgt ta
#ttgtaata 115380
agcgttaagc gacgtagaat taaaaaacat ccaatttatc gcccaaatac aa
#aaacaaga 115440
aggggcatac aaaatgcgac accagaatcc gatgtgatgt tggaggccgc ca
#ttgcacaa 115500
ctagcaacga ttcgcgaaga atccccccca cattccgttg taaacccgtt tg
#ttaaatag 115560
aactaattat cccggatttt atattaaata aactatatgc gttttattta gc
#gttttgat 115620
tacgcgttgt gatatgaggg gaaggattaa gaatctccta actataagtt aa
#cacgccca 115680
catttgggcg gggatgtttt atgaagcctt aaaggccgag ctggtataca cg
#agagcagt 115740
ccatggtttt agacctcggg cgaattgcgt ggttttaagt gactatattc cg
#agggtcgc 115800
ctgtaatatg gggacagtta ataaacctgt ggtgggggta ttgatggggt tc
#ggaattat 115860
cacgggaacg ttgcgtataa cgaatccggt cagagcatcc gtcttgcgat ac
#gatgattt 115920
tcacaccgat gaagacaaac tggatacaaa ctccgtatat gagccttact ac
#cattcaga 115980
tcatgcggag tcttcatggg taaatcgggg agagtcttcg cgaaaagcgt ac
#gatcataa 116040
ctcaccttat atatggccac gtaatgatta tgatggattt ttagagaacg ca
#cacgaaca 116100
ccatggggtg tataatcagg gccgtggtat cgatagcggg gaacggttaa tg
#caacccac 116160
acaaatgtct gcacaggagg atcttgggga cgatacgggc atccacgtta tc
#cctacgtt 116220
aaacggcgat gacagacata aaattgtaaa tgtggaccaa cgtcaatacg gt
#gacgtgtt 116280
taaaggagat cttaatccaa aaccccaagg ccaaagactc attgaggtgt ca
#gtggaaga 116340
aaatcacccg tttactttac gcgcaccgat tcagcggatt tatggagtcc gg
#tacaccga 116400
gacttggagc tttttgccgt cattaacctg tacgggagac gcagcgcccg cc
#atccagca 116460
tatatgttta aaacatacaa catgctttca agacgtggtg gtggatgtgg at
#tgcgcgga 116520
aaatactaaa gaggatcagt tggccgaaat cagttaccgt tttcaaggta ag
#aaggaagc 116580
ggaccaaccg tggattgttg taaacacgag cacactgttt gatgaactcg aa
#ttagaccc 116640
ccccgagatt gaaccgggtg tcttgaaagt acttcggaca gaaaaacaat ac
#ttgggtgt 116700
gtacatttgg aacatgcgcg gctccgatgg tacgtctacc tacgccacgt tt
#ttggtcac 116760
ctggaaaggg gatgaaaaaa caagaaaccc tacgcccgca gtaactcctc aa
#ccaagagg 116820
ggctgagttt catatgtgga attaccactc gcatgtattt tcagttggtg at
#acgtttag 116880
cttggcaatg catcttcagt ataagataca tgaagcgcca tttgatttgc tg
#ttagagtg 116940
gttgtatgtc cccatcgatc ctacatgtca accaatgcgg ttatattcta cg
#tgtttgta 117000
tcatcccaac gcaccccaat gcctctctca tatgaattcc ggttgtacat tt
#acctcgcc 117060
acatttagcc cagcgtgttg caagcacagt gtatcaaaat tgtgaacatg ca
#gataacta 117120
caccgcatat tgtctgggaa tatctcatat ggagcctagc tttggtctaa tc
#ttacacga 117180
cgggggcacc acgttaaagt ttgtagatac acccgagagt ttgtcgggat ta
#tacgtttt 117240
tgtggtgtat tttaacgggc atgttgaagc cgtagcatac actgttgtat cc
#acagtaga 117300
tcattttgta aacgcaattg aagagcgtgg atttccgcca acggccggtc ag
#ccaccggc 117360
gactactaaa cccaaggaaa ttacccccgt aaaccccgga acgtcaccac tt
#ctacgata 117420
tgccgcatgg accggagggc ttgcagcagt agtactttta tgtctcgtaa ta
#tttttaat 117480
ctgtacggct aaacgaatga gggttaaagc ctatagggta gacaagtccc cg
#tataacca 117540
aagcatgtat tacgctggcc ttccagtgga cgatttcgag gactcggaat ct
#acggatac 117600
ggaagaagag tttggtaacg cgattggagg gagtcacggg ggttcgagtt ac
#acggtgta 117660
tatagataag acccggtgat caccgaaccg gggcaacgcc gagcgtgtaa at
#ttaaataa 117720
aaaacagtac gcttttatcc ggtgtatgtt ttaaatttat tttttttttc ta
#tataaagg 117780
gatggggtgt caggatctct cgtaggttct tgggactcca agggacccgc ag
#cccaggta 117840
cgcgtcaaaa agcctgtgac aaattccccc ggggcggtca tataattcgg cg
#cggatgca 117900
tttattatcg ggcgacaatc caatagtcgg aagtccggcg tgtcccaaac ag
#caccaata 117960
tgccatcaat atcagccgct cgctgagctc cagatgcgat tgtggatccg gc
#atgcattg 118020
ctcgcgtaat aacgataaca ccgctctgcg gatcggcgga accgagggtg ga
#cgttgtct 118080
atccgctgcg agctccccgc acatccgtcc gaaggcgtcc tttgccctcc cc
#cacaaact 118140
cgcgcacggt ctctcggagg ggctgtgtat aaaagcctcg taggcctcgg ta
#gatatggc 118200
gcatagcgcg gcggcgaagt accgttcggc gtcgttcatg agagcctggt gc
#gcgggggt 118260
atcgtgtcgt gtgcagtaaa gtccggcata ttcaccgccc gggtgctcac cg
#cgggatcc 118320
gcagagattc ataccacacg gcccgtgtgg ggaccccgtg ggttaatgga ga
#cgttcaaa 118380
ccagcaccct ctaccctcta atatccacaa caccccactc ccccacagac ag
#acatcaaa 118440
aaaagacacg agccaaacca ttgtatttat ttataaagac tacacgccat gg
#gggggcgg 118500
tatatcatgc cggcgcgggg cttcgtgtcg acgtcgcttc caatctacac cc
#ccctcgcc 118560
caacgcggtg agcgctttcg cggctgtata ttccgcggtt tctgcacccg cg
#tatcgctc 118620
gatggcacgc tggggtctct ttggggacgg ggtgttgcac ccatccccgt ct
#cgataaca 118680
atcgccgggt accccgtctg gttcacaaga atcggtgctc tcctctgatt ct
#tcttccac 118740
tataaagtct tccccgtccg atgattccgc gtcggaatcc cgaaattcaa tt
#acatccga 118800
tggcgtagac ccatcatcgt cgctatcgtc ttcaccacca tcatcagata cg
#tcacattc 118860
cagtgcgctc ctatgcaaag gaacattcgg cgcctcaatg aacccgtctt cc
#ccccgagg 118920
gggtcgatgg gacacttcca ttaaagtagc gcgtaagcac tgcgtctggg tg
#ggttgaag 118980
ctgtaacaat tcctcccagc acgctaacgt gggacgctgt ctggtgcgac cc
#attagata 119040
aaagtcgagg catatgcgcc gcaatcttcg tgaatctcgc gtgacgcgtc cc
#gacgactg 119100
tgcaatacat aaaaaaacac ggttgatgtc ctcaacgagc ctggccgggt gg
#atctccca 119160
acccggagta caaaacgcgc cggggccccg cgacgtatcc cggccgttca gg
#ggtcctgg 119220
tgcagatcca tattccatct ttccgttaac atcaaccgat gccccgggtt tt
#gactcgga 119280
cgagtcgccc cgcgtagccg gtgaggtgca aaacatgtcc ttggggccgt ag
#taaccttt 119340
tcccttaaaa ccgactcgac gctgtcgcgt tatgaatcgg acgaaccctg ca
#caacaaaa 119400
cacacaccca aacgtttaca tctatgaata aggctacttg ggtaaaatgg ca
#atggggga 119460
ttccggggcg ggagaccttc gattgggttg cctttataac accaaaaaaa gg
#ggggggcc 119520
ccgtgtgttt ttttttatca cgtcaaatcg attttaaaaa gcctgccgct cc
#atttggaa 119580
tatatatatt ctgtgaaaag cccgcccaca ccccataaaa ccgcgacatc gc
#gggaacac 119640
gcgcgaacaa gaaactctct ctctttctct atatatatat atatatatat at
#atatatat 119700
agaaagaaag tgcgaacggt ggttggacac atgccaaaac atgaaaaccc at
#acagtgaa 119760
aaaacgggaa gtgcgaatgc agatcaaaag agtgtatccg attggcgtac ac
#cacagaca 119820
tgcggacgcc caatttaacc cccccccttt ttcacccccc caccccaccc ca
#ttccaccc 119880
caggaagtgc gaacgggttt acatgcctca gatatgaagt tcttcgactt gt
#ttttgaat 119940
aaattttttt gtgattttct acaacggttt agagaattat ggttataaac at
#cggcgggg 120000
taccgcgccc cctccccatc ggcggggtac cgcgccccct ccccatcggc gg
#ggtaccgc 120060
gccccctccc catcggcggg gtaccgcgcc ccctccccat cggcggggta cc
#gcgccccc 120120
tccccatcgg cggggggtta cgtgaacacc acaaccccgt gtgtatttta tg
#ggttatcg 120180
cgggcttcgt gccgcctgac ataatcgttg ggaggggtgg tggtgtatac gc
#ttgttgat 120240
tgcgcgaacg taatgacgac ggagagggac ccaaacacac cgtcgacgtg ca
#tttgatta 120300
actagatgcc ggatgggtgg aaacaacccg tgttatataa gatgttttgc at
#gtgagaca 120360
accccaattg tgtttatgta tattatatat cgtctgtaga cacacgatga tt
#ggttgtta 120420
tttaaacata tgtaaatgaa attcacatgt ctggtatccc ttgttatgat gt
#tgtaaggt 120480
atgcggaaat agacaccggg cgtacatcgc caaccagcgg tctctcctta aa
#cgcatact 120540
atggtccatg aacttcccgc ctcgagtctc gtccaatcac tacatcgtct ta
#tcattaag 120600
aatatttaca cggtgacgac acggggagga aatatgcggt cgaggggggg gc
#acaacacg 120660
ttttaagtac tgttggaact ccctcaccaa ccgcaatcgc aatcctttga ag
#gctgcgag 120720
agcgtttgga aaactcgggt acgtctaaat tcaccccagt gcgatggata cg
#ccgccgat 120780
gcagcgctct acaccccaac gcgcggggtc gcctgatact ttggagttaa tg
#gacctgtt 120840
ggacgcggcc gcggcggccg ccgaacacag ggcccgggtg gtcacctcga gt
#cagcctga 120900
cgatctacta tttggagaga acggggtcat ggtgggacgg gaacacgaga tc
#gtttcaat 120960
tccctccgta tcgggacttc aaccagaacc cagaacggaa gatgttggcg aa
#gagctaac 121020
acaagacgac tacgtatgcg aggacggtca ggatctaatg ggctcgcctg ta
#atcccgct 121080
ggccgaggtc ttccacaccc gattctcgga ggccggcgcg cgagaaccaa ca
#ggagccga 121140
tcgctccctt gagacagtct ctctcggaac gaagcttgct aggtctccaa aa
#ccaccgat 121200
gaacgatggg gaaacgggca gaggtacgac ccctccgttc ccgcaggcct tc
#tcccctgt 121260
atcccccgcg tctcctgttg gagacgccgc cgggaacgat caacgggaag ac
#cagcggtc 121320
tataccccga caaacgacga gaggaaattc accaggtttg ccgtcggtgg tc
#catcgaga 121380
cagacaaact cagtccatct cgggtaaaaa gccgggcgat gagcaagcgg gt
#catgcgca 121440
tgcatcgggg gacggagtag ttctccagaa aactcaacgg cccgctcagg ga
#aagagccc 121500
gaagaaaaag actttgaagg ttaaggtccc actcccggcg cggaaacccg gt
#ggacctgt 121560
acccggcccg gttgagcaat tgtaccacgt cctttcggac agcgttcccg ct
#aagggggc 121620
aaaggcggac ctgccgtttg agaccgatga tacccgccca aggaaacatg at
#gcccgggg 121680
tataacacct cgcgtccctg gacgttcgtc ggggggcaaa cctagagcgt tt
#ttggccct 121740
gccgggaaga tcccacgcac cagacccgat tgaggatgac agcccagtgg ag
#aaaaagcc 121800
aaagagtcgt gagtttgttt cgtcttcatc ctcttcctcg tcgtggggat cg
#tcatcgga 121860
ggatgaagac gatgaacccc ggcgcgtttc ggtgggaagt gaaactacag gc
#agcaggtc 121920
cggacgcgaa cacgcccctt ccccgtcaaa ttcggatgat tcggactcaa at
#gatggtgg 121980
gtcgacgaaa caaaatatcc aaccgggata tcgatccatc agcggtcccg at
#ccgaggat 122040
tcgtaagacc aaacgtcttg cgggggaacc ggggcgccag agacagaaat ca
#ttttccct 122100
gccgcgatcc agaaccccga taattccccc ggtgtcgggg ccgctcatga tg
#cccgacgg 122160
aagcccttgg cccggatcgg cacccctccc atccaacagg gtgcggtttg ga
#ccgtccgg 122220
ggagaccaga gagggtcact gggaggatga ggctgtgaga gcggcgcggg ct
#cgttacga 122280
ggcctcaacg gaacccgtgc cgctttacgt gccggagttg ggagatccgg ct
#agacagta 122340
ccgcgcgctg attaacctga tctactgtcc agacagagac cctatagcat gg
#ctccagaa 122400
ccccaagctg accggtgtca actcggccct gaaccagttc taccaaaagc tg
#ttgccacc 122460
gggacgggcg ggtaccgccg ttacggggag cgtagcgtct cccgttccgc at
#gtaggcga 122520
agccatggcc acgggggagg ccctctgggc tctcccccac gcggccgcgg cc
#gtggctat 122580
gagccgtcga tacgaccggg cccaaaaaca ctttatccta cagagtctcc gc
#agagcctt 122640
tgccagcatg gcataccccg aggcaacggg ctccagtccg gcggcgcgga tc
#tcccgcgg 122700
tcacccttct ccaacaaccc cggccacaca ggctcccgac cctcagccgt cg
#gccgccgc 122760
acgctctctt tctgtgtgtc caccggatga tcgtttacga actccgcgca ag
#cgcaagtc 122820
ccagccagtc gagagcagaa gcctcctcga caagattagg gagacacccg tc
#gcggacgc 122880
ccgggttgca gacgatcatg tggtttccaa ggccaagagg cgggtatccg ag
#cccgtgac 122940
catcacctcg ggccctgtgg tggatccccc cgccgtaata acgatgccac tt
#gacggacc 123000
ggccccaaac gggggatttc ggcgtattcc ccggggggcc ctgcataccc cg
#gtcccgtc 123060
ggaccaggct cgcaaggcgt actgtacccc cgaaaccatc gcccgtctgg tc
#gacgaccc 123120
attgtttccc acggcctggc gccctgcgct aagctttgat cccggcgcct tg
#gcggaaat 123180
cgccgctcgg cgtccgggcg gaggagaccg acggtttggt ccacccagcg ga
#gtggaggc 123240
gctgcgacgg aggtgcgcct ggatgcggca gatcccagac ccggaggatg tg
#aggcttct 123300
gatcatctac gatccgttgc ccggagagga catcaacggc cccctcgaga gc
#accctcgc 123360
gacagatccg ggaccgtcat ggagtccatc ccgaggggga ctgtctgtgg tc
#ctggcagc 123420
cctgagtaac cggttgtgcc tgccgagcac tcatgcctgg gccgggaact gg
#accggccc 123480
gccggacgtg tccgctttga acgcccgggg cgttttatta ctgtcgaccc ga
#gacctggc 123540
ctttgccggg gccgtcgagt atctaggctc gcggttggcc tctgcccggc gc
#cggttgct 123600
ggtgttggac gcggtggccc tcgagaggtg gcccagggat ggacccgctt tg
#tctcagta 123660
tcacgtgtac gtccgggccc cggcgcgacc ggacgcccag gccgtcgtcc ga
#tggccaga 123720
ctcggcggtc acagaaggac tcgcccgggc cgtgtttgca tcgtcgcgca cc
#tttgggcc 123780
agcgagtttt gctcgtatcg agactgcgtt tgccaacctg tacccgggcg aa
#caacccct 123840
gtgtttgtgc cgcggtggga acgtcgcata caccgtgtgt acccgcgcgg gc
#cccaagac 123900
ccgcgtcccc ctgtcgcccc gtgaataccg gcagtacgtg ctgccgggtt tt
#gacggttg 123960
caaggacctc gcgcgacagt ctcggggtct ggggctcggg gcagccgact tt
#gtggacga 124020
ggcggcacat agccaccgcg cagcaaaccg atggggcctg ggtgccgcgc tt
#cgacccgt 124080
cttccttccc gagggacgga gaccgggggc cgccgggccg gaggccggcg ac
#gtacccac 124140
ctgggcgagg gtgttttgcc gccacgccct gctggaaccc gaccctgccg ca
#gaaccact 124200
cgtgcttcca cccgtggccg gtcggtcggt ggcgctgtat gcgtcggcgg ac
#gaggctcg 124260
gaatgccctc cccccgattc ccagagtaat gtggccgccc ggttttgggg cc
#gcggagac 124320
ggtgttggag gggagcgacg gaacacggtt cgtgttcgga caccacgggg gc
#tcggaacg 124380
gccgtcagaa acccaggcgg ggcgacagcg gcgcaccgca gacgacagag aa
#cacgcttt 124440
ggagctggac gattgggagg tggggtgtga agacgcgtgg gacagcgagg ag
#gggggcgg 124500
ggacgacggg gacgcaccgg ggtcatcctt tggggtgagc atcgtgtcgg tg
#gccccggg 124560
tgtgctgcga gaccgccggg tgggtttgcg cccggcggtc aaggtggagc tg
#ttgtcctc 124620
gtcctcgtcc tccgaggacg aggacgatgt gtggggaggg cgcgggggga gg
#agcccccc 124680
gcagagtcgg gggtgacgga gtcccctcct tttctcgtga gcgccactgg cg
#cgcggact 124740
gtttgttgtt aataaaagcg gaacggtttt tatgaaaaaa gtgtctgtct gt
#ctgtgcgg 124800
gcgggcgacg ggcgggctgg tcggaccccc ccccgaaaat aacccccccc cg
#gtttctgg 124860
gcgcccggcg gaccccggga gagg
#
#            124884
<210> SEQ ID NO 2
<211> LENGTH: 125157
<212> TYPE: DNA
<213> ORGANISM: Varicella virus
<220> FEATURE:
<221> NAME/KEY: misc_feature
<222> LOCATION: (1)..(125157)
<223> OTHER INFORMATION: Attenuated Oka strain
<400> SEQUENCE: 2
ggcccagccc tctcgcggcc ccctcgagag agaaaaaaaa aagcgacccc ac
#ctccccgc     60
gcgtttgcgg ggcgaccatc gggggggatg ggattttttg ccgggaaacc cc
#ccccgcca    120
gcctttaaca aaacccgcgc cttttgcgtc cacccctcgt ttactgctcg ga
#tggcgacc    180
gtgcactact cccgccgacc tgggaccccg ccggtcaccc tcacgtcgtc cc
#ccggcatg    240
gatgacgttg cgacccccat tccctaccta cccacatacg ccgaggccgt gg
#cagacgcg    300
cccccccctt acagaagccg cgagagtctg gtgttctccc cgcctctttt tc
#ctcacgtg    360
gagaatggca ccacccaaca gtcttacgat tgcctagact gcgcttatga tg
#gaatccac    420
agacttcagc tggcttttct aagaattcgc aaatgctgtg taccggcttt tt
#taattctt    480
tttggtattc tcacccttac tgctgtcgtg gtcgccattg ttgccgtttt tc
#ccgaggaa    540
cctcccaact caactacacg aaactactgt ccggaagggg aaggtattta tt
#ctcgcttg    600
cagcttgtcg cgcgtgtatg cacaacaaaa gctatatatg tcaccaaagc ca
#acgtcgcc    660
atctggagta ctacacccag tacattgcat aacctgtcca tytgcatttt ca
#gttgcgcg    720
gacgcctttc tccgggatcg tggccttggg acatcaacca gyggaataag aa
#ccgccggt    780
ggtcttgccc gaacgacgag tggcgacgcg ttgttctgca taagctctgt at
#gctgatac    840
ataaacacag agtctgtatc gctatcagat tcccgaacac cttccggtac cc
#catactcc    900
gataccctgg acattgcgga tcccaaaaat ataatattaa caggatttgc tt
#atactttg    960
ctacagctta tataaattta tgtgcgatac atcttaagtg catccgtacg tt
#atttatac   1020
attgcctgtc acgtgaaaag actgtgttac ccaataaagg ttctacaaaa aa
#tgctttat   1080
tgggtgtttg tttaatagct attatcgtaa cccacccccg taaaatcata aa
#atgcatgt   1140
aatttctgag acacttgcat atgggcatgt tcccgcattt attatgggct cc
#actctggt   1200
gcgtcccagt ttaaacgcca ccgccgagga aaatcccgcg tcagaaacgc ga
#tgtttatt   1260
acgagtgctt gcggggagaa ctgtagacct gccaggcgga ggaacgttac ac
#attacctg   1320
taccaaaacc tatgtaatta ttggcaaata tagcaaaccc ggcgaacgtc tt
#agccttgc   1380
ccgtctaata gggcgtgcaa tgacgcctgg aggtgcaagg acatttatta tt
#ttggcgat   1440
gaaggaaaag cgatccacaa cgcttgggta tgaatgtggt acgggcttgc at
#ttactggc   1500
tccatctatg ggtacatttc tccgcacaca cggtttaagt aacagagatc tc
#tgtttatg   1560
gcggggtaat atttatgata tgcatatgca acgtcttatg ttttgggaga at
#atcgcgca   1620
aaataccact gaaacacctt gtataacgtc gacgttaaca tgcaacttga ca
#gaagactc   1680
tggtgaagcc gcacttacca cgtcagaccg acccactctc ccaaccctaa ca
#gcccaagg   1740
aagaccaaca gtttccaaca ttcgtggaat attgaaagga tccccccgtc aa
#cagccggt   1800
ctgtcaccgg gttagatttg ccgaacctac ggagggcgta ttgatgtaat ca
#ctaaataa   1860
aatacacctt ttttcgattg tacgtatttt tatttaaatg tgtagttcat ag
#tccgccga   1920
cagccgctcg ggcttttccc ccacatacaa catgatcgta tgcctcggat gc
#accggtcc   1980
aacactccgc cgagaagggg gatttacaat gacagtgata cccaatagcc gc
#cagatgta   2040
cacccagctg tccggactcc agcatcatct gctgagttgc ggcgctgaag gg
#tgcatcgc   2100
atagggtgtt ataattagcc atttccggta acagtcgttg ggaatttagg ag
#gctgcaaa   2160
acggctgtag gtcaacatac attggggatt cagatggttt atctcgacgt cc
#aagtccaa   2220
tcaaaaaagc gtgtaaatca tcagcccggc cgcatgttgc tcgaagagca ca
#taacctct   2280
taacaccgta cagaggggat ggcgtcggtg catgtgagtt ggcagggcat gt
#ccacgttg   2340
tttccaacgc cagtggcggt ataacttgtg taaacgacgc caacgggtca gg
#tttaagat   2400
tcactcggat gggttgactg ctttcggaag ctcccgttgt atccattaat ta
#aacgttcg   2460
gtacacgtct ggtgtgtgtt ttacccgaat cagagacgga attgcaaaga ta
#tyggtttg   2520
aaagcaatgt aatcccgccc atatatcccc aacgtcgcct taaaaactcc ca
#caatatta   2580
catttttatt agtcttttat taatatagaa tcacataaac aattgataaa at
#caaggggt   2640
ggtgtataat gattaaaaat ataaattgat atgttttaca agcatgaaat ag
#gtatttac   2700
tattctaaca ggtaaatatg cttaatgatt aaaaatacaa attagtatgt tt
#tgacaagc   2760
atgaaaaagg tattttttat tttagcagtt aaaggtacta cacttaaaat at
#ttaccgta   2820
tggacgggcg tcagaaagat gcccggccca agttgagagg gtacattcaa ca
#cgaccaca   2880
ctcgcgttgg tgggtgatta gggcctctaa aacaccggcc agacatgacc cg
#ggtgtata   2940
ttcttgtaac acttgaacgt tacaactgat atcatcatat tccacaaatt ta
#gagccacg   3000
gacaactata ttagcaatgc gggcaatcat aacaaacata taagtagtaa ta
#cacgtgat   3060
atcactaaaa cgttgctggc gcaacagttc ggggagagta cgagacccca aa
#tcgttgtc   3120
cctgtttaga agaagacatc ttacaaaagg ccccagcttt aactttaaat tc
#tccaaaag   3180
tgacttcgag gttgcaacaa tgggattatt tgtgtagatg ggcaagtttt tt
#gccgctaa   3240
cattttaatc cacgttaaca gttcatccgc agactccaac gcttcaatca aa
#gattctcc   3300
acgtatgact ctctcacgca acgcgcgggc aatacgtgag tccattttat at
#gactcaaa   3360
ggtacgataa agttcatgtc cgtacaacat caactccggc caagatgtgt tt
#tgttttat   3420
ccccggaaaa catccaccgg aagcccatga atcaccctct tgtattgtgg ca
#tatcggac   3480
taccagtttt tcaattgttt catctaaatg gcgtaccgag tcaatggtca cg
#ctggctcc   3540
cgcggtggag acgacttcaa tagcacggcc cgtaattcga tcgaccggga ta
#tcatactc   3600
ttttcgaata cgctctcggc gggcgtctct cttggaaaat cgcaacctgt ac
#gattcgtc   3660
atgtgtctga tcatttcttt ctcccgtggt cattgcagga ggcgttgtag ga
#cgccgtct   3720
tcgatttgac agggatcgat cacggtgttt tcttgaactt tgggtgttat aa
#gatctgga   3780
tgatcgtcga tgtccccgtt cgatgcgtgc atatccagtc tccacgtctc tt
#cctccatg   3840
atggtttgaa tcgggtaata caacaaccaa agttttcggg cgattgtggt gg
#tagctttc   3900
acgccttccg tgccttcgtt tggaataccg tggattatat gctgtatctg ca
#gtacgctc   3960
cacatacaca gttctagacg ttgtggagtc ctcgcctgga gtggagccaa ta
#gcttcatc   4020
atttgcccaa tcggtgactt ccaatgcaaa gtcatccgaa ggttcgtctg gt
#agcaaatt   4080
cataaagtct tcacaaatag tagacacgtc tgggtcggtt ggaattgaag ca
#gaggccat   4140
ggctgcaaaa tatctgacaa ttgcgtgttt gcagttgcct gtatcttccg cc
#aatgttgt   4200
agaatttata ggctcaccca accccgcaat gggcgtgttt agtcacatga tt
#aatgtttc   4260
tgggagtttt cactttcccc aaacaagctt acctgcaccc tttgttcgta at
#gcataaaa   4320
ataaccactg ctatagcaaa tatgacgata taaaaacatt ttatagcaag gc
#cggacatt   4380
actgtagcgc aacatgttgt gcatatacca cgtattcccc ccgtattgat at
#gatttaaa   4440
tgattatcct tggttggttt tggtctaaca taagatataa gctctactat ag
#cgagcgtg   4500
catacaacaa cccaggccag aatccgaatg tatgtggggt ataataacgc gc
#atggtgta   4560
tatgcaacgc caagcgttaa aagcacaata catccagatg atatatgagc ga
#taacctcc   4620
aaaagcatca ataacgtaac acctttatgc atatataaaa aacttatagg gt
#cagcatta   4680
aatactttac tcataccatc ccgtcgcatg gaaacatcac ataacaacct tg
#ccaacttt   4740
gtatatgggt aaccaagaag aatgttcgaa ataacccgtg ttacgtaatt ca
#gtgaatat   4800
gatgtggggg atattaactc acaggatgat cggaatggcc caaacatacg ac
#gtattcgt   4860
cgaaattgta aatacatacc atatacaaac catgcaaaaa aaatcatttt ta
#gctgcacg   4920
caccaaaaat aagcgtgaca attacgtgtt cccagaacaa ttcgaatttt gt
#catgcaaa   4980
ggtgtagaaa tagcggtttt taccatagta tctcctgata atagattttc cc
#ggcagctg   5040
taatcgtatc cagataggcc atccaaaaac gttgagtggt ttacaaacgt ta
#catatata   5100
agagagttgt tataagaccc ccatacaacc ggtccaccat taatcaccgt gg
#ttgcatac   5160
acacactcat gttcaaactt tacacgagcg gtataccata gggtaaaaac ag
#catgtccg   5220
ctaagtagac acataattat aaaatgttct gtcttgattc ctaaagcctg ca
#tgacccgt   5280
ggaagatggc aattcaagca cgatgtagta tcacacggtt ggtgttaact cg
#aagttaaa   5340
tttggataat taggtacttc tagagtaaag attgtatgca tgcgattgct at
#cgcacttt   5400
gtagcaaaac attgttgtgc aagcgaaata cacaaacggt tgtgatgatc ca
#ctcgcaga   5460
gacacaaatg tccggggagc cgttcttcct ccgcgatggg gatatcgaag ac
#aagtgaac   5520
ccttttgttc cgcatatgag ctgaaataac acccagtccc ttttgatggc ga
#tacacttt   5580
gatgatgtta aggtatattc gcgatcacgc ccggggaaat gaacagcaat at
#gctccaca   5640
atagattcta atattgtgct gtcgacaaag gcctccagtg taaatgcgtc ca
#gacaagtt   5700
accccgcgct cttttagagc ctttgttaaa gatatttgcg gggggctaaa ta
#tttgttta   5760
ttacgcgcaa ccttacgttc aaaaaactct gcgtattccc ccccaaggtt at
#gtaaaata   5820
aattgcactg gaacattcga ctgcggtctt gaatgaaaat gaaagtttgc cg
#ggtttcta   5880
tgtgatgtca caaacgctaa tatatcaata cactgctcag gtacaacata aa
#atgggagt   5940
agttgtccaa ccgccgtccc tgtggttgtt actttggaga aaaaaggcag tc
#ttaaacta   6000
tgtccgtggc tataaacacc agtatctata aacgaaaagt cccgtaaata cg
#gaccaata   6060
tattcaacaa attcccgttc cagcaacacc gcttgctgta atatttgtgc aa
#accccttt   6120
aaagtggaag accccactaa cgcataggga tttgggattg gtacgcatac cc
#tgaaacct   6180
attttctctt tacagttaca gggtagagtt tcatgcaagt tttcattgtt tg
#atacatcg   6240
gcgtgtgtat ggacttcaga cgttgtctgt gtatcaaaaa accatacatc ct
#ctgtataa   6300
ttctcttcta cacacgtgta taattcgcca ttttctatgt aaaaatcgat gt
#cagaatgg   6360
ctggttatat ccaataaatt atcatcatcc aacacctcaa cggtaggttc ag
#gacatgca   6420
gttttataaa aataacatgg gtctttgtta gggtttacca cggcctttgg aa
#aaagtaat   6480
tgcatggccg ttaaaatacc atgacgaaat gctcgcatgc cggcatgtaa aa
#tacccaat   6540
gggatgggtt ttcttatatg aaagtctaca tcaagtatga ggtttgtgat ta
#taagattt   6600
gtattaaata gctcattcct gtttatataa agctgatctt tgggtatgtt tg
#atgaaatt   6660
ttagaaacgt ttttaacaga cgtagataat agtaaagtca actgcatatc tc
#gtagtgaa   6720
gcggcaacaa aattacatgg attaatttgt ttaaggtcct ccgcaattaa tc
#gagcctcg   6780
tgcggtaaag tgtaacggtt tgttattgat gaccacgtat cattagcaat aa
#cagcaaat   6840
gcttgggcgc cttgaggcaa ggctacccga tatacaggca ttggtccagt ta
#cctcagaa   6900
tggccgatga gggcttctaa tggagtttta taactcagga tggatacatc at
#gtgtggct   6960
atcccagtgg cagcagagaa aaacagtaat agttttgtaa tccccgggct cg
#tatcaaaa   7020
ccagtacgac cactttggtt aggtgtatcg tttgcaaagt tggctgctcg ta
#acgcctcc   7080
gcggaaacaa ccgaatcctc aaaattagac aattcgtcaa aaccgggtgg at
#ttgaggga   7140
atagtggagg accatccata tggactaaat tgtttttcaa tgttttccac ac
#gacgagtt   7200
agcgttgtag ctaggtcaca tacgcctata aacttgctag gttttgcggc at
#acgtaaga   7260
cttaaagtat atgttttagt aattgtatat ttatgtccaa tctcaggtcc aa
#gttcagtg   7320
acatcacaaa ttacgttctt ttttatatag tcacgcatgt tgagacgaga ac
#gtacatga   7380
ttaaaaaaat tagcagtagc tctttttccc aggttggatg attttaagag ga
#ccggttta   7440
ttcacaaaat ctgagtatgt aaccgcttgt aggtggtctg cgatctgttt cc
#gattgaaa   7500
cattcaaaat gtgccagata aatataatca acaaattcac ggtctggaac tt
#taaggcct   7560
tttctatcgt tggtaatata ctccgatact gcgtgtattt ccgttgtgtc tg
#tatgtatt   7620
cgctgtaaaa tgtacgatag agcatttttg gctgtcaaac ctcgtgtata tg
#ttgaggaa   7680
caacaaaaca tggaaagttt atcaaaagac aacaagtccg aaatattgta cc
#cactacaa   7740
ttaggtaatg ctgggacttg gtaagttaaa aacaaatctt taattgcctg ta
#agtcatat   7800
aagggggttt ccaacgtatt gtaacttgtg tccgtttgta acaagtaata gc
#gtgtagcc   7860
aacactagcg ttttttcaga gggtccaaat cgaacaatat accaaaacgg cg
#agcatcca   7920
tacccccagt agagtcgtcg atatgcagcc aatacttgac gttcgtaatg gg
#catataat   7980
gatgttagct cctgacgacc aacggatttt ttaactaact tgcagagtgt tg
#cctctgtg   8040
atgcataggc cgttgtccga taatcccttt cggtttaaat ggtgtgttgt ta
#ccatcaga   8100
gtttgtataa cttccgagtg aatgtcaaac gtctccgata tacatagggt at
#cagatatt   8160
atatgcggat ttaggggtgc tccataccat aacgccttat ataaagcttt aa
#aatcagtt   8220
tgggttttaa aacaacaaaa aaatataggc cagacccggg atcgtacatc tc
#cagttgaa   8280
aatccaccaa ttaaataaaa aataacgttg acgtccctac tacaaaataa at
#gcattatt   8340
tggttttctt catcgttttc agttacttca cgtgggcgtt tagttgggat ta
#cttgcgtg   8400
atctcttccc tcccattttt gacaaagacg tcatctaagt cgggagtcca ag
#tataactc   8460
accacataca gaggttctgt gcttatctgc ccggtaagca acaacagcga gt
#gggagatt   8520
gcacatccct ttgtggcaaa taataaccga atcgtcggtt tggaggattt at
#ccatagtt   8580
caatacgttg gaaagccagt caatcatgca gacggtgtgt gccagcttat gt
#ggatatgc   8640
tcgaatacca actgaagagc catcttatga agaggtgcgt gtaaacacgc ac
#ccccaagg   8700
agccgccctg ctccgcctcc aagaggcttt aaccgctgtg aatggattat tg
#cctgcacc   8760
tctaacgtta gaagacgtag tcgcttctgc agataatacc cgtcgtttgg tc
#cgcgccca   8820
ggctttggcg cgaacttacg ctgcatgttc tcgtaacatt gaatgtttaa aa
#cagcacca   8880
ttttactgaa gataaccccg gtcttaacgc cgtggtccgt tcacacatgg aa
#aactcaaa   8940
acggcttgct gatatgtgtt tagctgcaat tacccatttg tatttatcgg tt
#ggcgcggt   9000
ggatgttact acggatgata ttgtcgatca aaccctgaga atgaccgctg aa
#agtgaagt   9060
ggtcatgtct gatgttgttc ttttggagaa aactcttggg gtcgttgcta aa
#cctcaggc   9120
atcgtttgat gtttcccaca accatgaatt atctatagct aaaggggaaa at
#gtgggttt   9180
aaaaacatca cctattaaat cggaggcgac acaattatct gaaattaaac cc
#ccacttat   9240
agaagtatcg gataataaca catctaacct aacaaaaaaa acgtatccga ca
#gaaactct   9300
tcagcccgtg ttgaccccaa aacagacgca agatgtacaa cgcacaaccc cc
#gcgatcaa   9360
gaaatcccat gttatgcttg tataaatatt gaaataaaaa ctaaaaacgt tt
#ctggtgta   9420
tgtttttatt ttgtatataa aattaaaaca ttgctggccg gcgtggttat ta
#catttaat   9480
gttttagtag aaaatcgaca tcgtttgttt ctttatcagt tgaaccaaat cc
#acgcgttc   9540
cccgttcgct gggtgtggct attagatcta acgttttagt aaaataccat tg
#tacacccg   9600
gtatgccaca tttaccgcgg atagcataag gaaatgcaat attacttaaa ac
#gttgtgtt   9660
ttaagtgtat ttgggtgttg tgatctatta acaggacctg tgcaagacga tc
#tcccgttt   9720
ttatacgtat gtcatcaccc gtgagattat atacgtagaa tttacagtgt tc
#tcctgcag   9780
gccatgccgt tggacacacg ataatgcctg atcggctttt cgatgatctt cc
#aaaaatat   9840
aagcgtttat actcggatgt tgtaagtccc agtctcttat aatcggtaag ac
#aattttta   9900
taaattcatt cctttttaaa tataggttat atggtacaca aatatcatat cc
#cgcgtctt   9960
cttggcgttt tggattgatg atatgtttgt aggttaaggg aacatcgata tg
#gtattctg  10020
cagaatccct atgtaaaggt tgcccctgct gtaccgtgga aatatcagca aa
#ttcagata  10080
taacgggttt ttcataattt gacggcgagt ttgataaggg ttgaacttgt at
#cgatttaa  10140
aaattggatc cagatgttta agaacgtttt ttgggagaag gcgactttgt ct
#taatttta  10200
ccgggaacaa gtagattgtt aaatgtccgg gtaaaataac ggttactcct gg
#ccggtaat  10260
acaaaagggc tgaaattact cctctgtaac ccgcatcaat aactccgttg gc
#gacaaaaa  10320
aattgtcttc atcagcaagg gcagtatctt tgcattgaat taacaacagt gc
#gtattcat  10380
tgggaggcgc cgacttaacc aacagctcca actgctgcat ataaaaaccg cc
#ccgtgtta  10440
cagatttttc agatggcagt tcgagtttct tgtggttccg gagtaacaac gg
#ttgatgtc  10500
gacttacttt atcgtctaac acgcattgca gcgtatctgc acattcaggt tg
#aacttcta  10560
ttaaaattgt atcttttaaa caccgattcg gaatagtttg gctacaaaac at
#atcacctg  10620
tatttactgc cgtttccaag atgggatcaa ttaccgcttc gttcatatta at
#aacgatgc  10680
aaattttatt tttttgtgaa gacagcagtg gggagccaaa ctttgcagaa cg
#gaattttt  10740
ggcatgccag ctgttcggct cgtggagttt atatcgacgg atcaatgatc ac
#cacccttt  10800
tcttctacgc atcccttttg ggggtgtgtg tagcccttat ttcgttagct ta
#tcatgcgt  10860
gtttccggtt atttactcgt tctgtattac gcagcacgyg gtaaacccgt tt
#gcctataa  10920
aaggggcagg cgtgtataag agggcccctg tttaatacgc ggtctgccgt gt
#ttggatat  10980
ttcacgaccc tatcgtttat ttacgtaatg gcatcttccg acggtgacag ac
#tttgtcgc  11040
tctaatgcag tgcgtcgtaa aacaacgcct agttattccg gacaatatcg aa
#ccgcgcgg  11100
cgaagtgtgg tcgtaggacc ccccgatgat tcagacgact cgttgggtta ca
#ttaccaca  11160
gttggggccg attctccttc tccagtgtac gcggatcttt attttgaaca ta
#aaaatacg  11220
acccctcgcg tacatcaacc aaacgactcc agcggatcgg aagatgactt tg
#aagacatc  11280
gatgaagtag tggccgcctt tcgggaggcc cgtttgagac atgaactggt tg
#aagatgct  11340
gtatatgaaa acccgctaag tgtagaaaaa ccatctagat cttttactaa aa
#atgcggcg  11400
gttaaaccta aattagagga ttcaccgaag cgagctcccc cgggagcagg cg
#caattgcc  11460
agcgggagac caatttcctt cagcactgca ccaaaaaccg caacaagctc gt
#ggtgcggt  11520
cctacgccat catataacaa acgcgtcttt tgtgaagcgg tccggcgcgt ag
#ccgccatg  11580
caggcacaaa aggctgccga agcggcttgg aatagtaatc ccccaaggaa ta
#acgccgaa  11640
ttagaccgtt tgttaaccgg agccgttatt cgtattacgg tgcatgaggg tt
#taaattta  11700
atacaagccg ctaatgaagc agacctaggt gaaggagcat cggtatccaa ac
#gtggacat  11760
aatcgaaaaa ctggagattt acaggggggc atgggtaatg aacctatgta cg
#cacaagtt  11820
cgtaagccaa aaagtcgaac ggatacacaa acgactgggc gtataactaa tc
#gaagtagg  11880
gcccgttcgg catcaagaac tgatgcgcga aaatagggat ataattacgc ag
#taacggtt  11940
tacccggtat tatgtataat aaataaacgt ataaaagaca gtcgtggttt gt
#gtttatta  12000
taaatgtgta ttatatgtca catattataa actgtttaaa tagtaccacg tg
#gtattatg  12060
aacagtttat aatcagttgc taccaaacaa accccattag acggcgggtt tt
#gataaagg  12120
gaatcgctta tttaaactaa agattttact ctataagtat ggagtgtaat tt
#aggaaccg  12180
aacatcatag tacagatacg tggaatcgta gtaaaacgga acaagcggtt gt
#ggacgcat  12240
ttgatgaatc gttgtttggt gatgtagcat cggatattgg atccgaaacg tc
#gttatatt  12300
cacatgcagt taaaactgct ccgtctccgc cttgggtagc tagccctaaa at
#tttatatc  12360
aacagttaat acgggatctt gatttttcag aagggccgcg tttactatca tg
#tcttgaaa  12420
cctggaacga ggatttattc tcatgttttc ctattaatga ggacctatat tc
#cgatatga  12480
tggttttatc cccggatcca gatgacgtta tctcaaccgt ttcaaccaaa ga
#ccatgttg  12540
aaatgtttaa tttaacaacc cggggttccg ttcgattgcc tagtccacca aa
#gcaaccga  12600
cggggcttcc agcttacgtt caggaggtcc aggattcgtt taccgtagaa ct
#acgcgccc  12660
gggaagaagc atacacaaaa ctactagtta cttattgtaa atcgattata cg
#ttatctcc  12720
aaggaacggc gaaaaggacg acaataggtc ttaatataca aaaccctgac ca
#gaaagytt  12780
acacgcaact caggcaaagt attctactta gatattatcg tgaggtggca ag
#tttggcgc  12840
gtcttctgta cctacattta tatttaaccg taacgcgtga attttcctgg cg
#tttgtacg  12900
ccagtcaatc tgcacacccg gacgtgtttg cggctttaaa attcacctgg ac
#cgaacgtc  12960
gacagttcac gtgtgcgttt catcctgtat tatgcaacca cggcattgtg tt
#attagaag  13020
ggaaaccact aacagcgtct gccttgaggg aaataaatta ccgccgccga ga
#actgggac  13080
tgcctctagt tagatgtggt cttgttgaag aaaacaaatc tccgttggtt ca
#acaaccct  13140
cattttcggt tcatttacca cggtcggtgg ggtttcttac ccaccacatt aa
#gcgtaagt  13200
tagacgcata tgcggtcaaa catcctcaag aaccgagaca tgtacgagcg ga
#tcatcctt  13260
acgcaaaagt tgttgaaaat agaaactacg gtagtagcat cgaagctatg at
#tttagcac  13320
ctccgtcccc atccgagatc ctgccggggg acccaccacg cccacccacg tg
#tgggtttt  13380
taacgcgtta aacgtcattg gggtaaaggg tgtaaataaa ttacgaaaac gt
#gcatgcgt  13440
tttttatttt tacaatgcgc cgtatatggt atgtctgtca tgtgctctaa ag
#tcccatat  13500
ataaaagaag ccccaacgag tgtatgcgta ttgcgtaccg cgaccctggg at
#gttttaca  13560
ggcgcgtttg tttgtctcgg ttataagtat gcagtcgggt cattataacc gg
#aggcaatc  13620
ccgccgacag cggatatcgt ctaataccac agactccccc cgtcacacac ac
#ggaacacg  13680
ttatcggtca accaattggt atacacaccc accccagata ttgtccaatt ca
#gaaacatt  13740
agttgcggtt caagaactac tgaactccga gatggatcag gacagcagtt ct
#gacgcatc  13800
ggatgatttt ccgggatacg ccttacatca ttctacatat aatggatccg aa
#caaaatac  13860
atcaacttcc agacatgaaa atcgcatatt taaattaacg gagagggaag ct
#aatgagga  13920
aatcaacatc aatacggacg cgatcgacga cgagggagag gcggaggagg ga
#gaggcgga  13980
ggaggacgcg atcgacgacg agggagaggc ggaggaggga gaggcggagg ag
#gacgcgat  14040
tgacgacgag ggagaggcgg aggagggaga ggcggaggag gacgcggcgg ag
#gaggacgc  14100
gatcgacgac gagggagagg cggaggagga cgcgatcgac gacgagggag ag
#gcggagga  14160
ggacgcgatc gacgacgagg gagaggcgga ggaggattat ttttctgtaa gt
#caagtttg  14220
cagtcgagac gcggatgagg tttattttac gttagacccg gaaataagtt ac
#agtaccga  14280
tcttcgcatt gcaaaggtta tggagcctgc ggtatcaaag gaacttaatg ta
#tcaaaacg  14340
ttgcgttgaa cctgttaccc taacaggctc tatgttagcg cataatgggt tt
#gatgagtc  14400
ctggtttgct atgcgcgaat gtacccgtcg cgaatatatt acggtccaag ga
#ttatacga  14460
cccaattcat ttacggtatc agtttgatac ttcccggatg acacccccac ag
#attttgag  14520
aactatacca gcccttccta acatgacact tggtgaactt ttattgattt tt
#cctattga  14580
atttatggcc cagccaattt ctatagaacg tattttagtt gaagatgtat tt
#ttagatag  14640
gcgggcttcc agtaaaacac ataaatacgg cccgcgttgg aattccgtct ac
#gcacttcc  14700
atataatgcg ggtaaaatgt atgtacaaca cattcctggg ttttatgacg tg
#tccttacg  14760
tgctgtgggc caaggaacgg ccatttggca tcacatgata ttatccacag ca
#gcatgcgc  14820
tatttctaat cgcatttcac atggagatgg attaggattt ttgttagacg cg
#gcaattcg  14880
tattagcgca aactgtattt ttttgggacg taacgataat tttggcgtgg gg
#gatccatg  14940
ttggttagaa gaccatcttg ccggattacc acgagaagcc gtacccgacg ta
#ctccaagt  15000
gacacagttg gttttgccaa atcggggtcc aacggttgcc attatgcgtg gt
#ttttttgg  15060
ggcgttggca tattggcccg aactaagaat tgctataagt gaaccatcta ca
#tctttggt  15120
gcgatatgct accggtcaca tggaacttgc cgaatggttt ttattttcac gt
#acacatag  15180
tttaaagcca caatttaccc caacggaacg ggaaatgtta gcgtcatttt tt
#acgttgta  15240
tgttactctt ggtggaggaa tgttgaactg gatctgtaga gcaactgcaa tg
#tatttagc  15300
tgctccttac cattcccgtt cggcttacat cgcggtctgt gaatctctgc cc
#tattacta  15360
tatcccggtt aatagtgacc tgttatgtga tttagaggta ttactgttag gc
#gaggtcga  15420
cctcccaact gtttgtgaat cctacgcaac tattgcacac gaattaaccg ga
#tatgaggc  15480
tgttcgcaca gcagccacaa attttatgat agagtttgcc gattgttata ag
#gaaagtga  15540
gaccgattta atggtaagcg cgtacctggg ggccgtttta ttgttacaac gg
#gtgttggg  15600
tcatgcaaat cttcttttgt tgcttctctc cggtgctgcg ttgtacggag ga
#tgttcaat  15660
ttacatcccc cgaggtattt tagatgcata taatacttta atgttggcag ca
#agtcctct  15720
ttacgctcac caaactttaa catccttttg gaaagaccgc gatgatgcaa tg
#caaacttt  15780
ggggattcga ccgacaacgg acgttttacc caaagagcaa gacaggatag tt
#caggcatc  15840
acctatagag atgaacttcc gttttgtggg attggagacc atctatcccc ga
#gaacagcc  15900
cattccctcc gtggacctag ccgaaaatct tatgcaatac aggaatgaaa tt
#ctgggttt  15960
ggattggaaa agcgtagcca tgcatttact acgaaaatat taagggttgt ga
#tttttttc  16020
attaggatga aaagaacgtt tcctagccac acccacaaag gagtttgtaa aa
#taaaatct  16080
ctgtttagac cttaaaattt gttgtgtgtg ttgtgtgggg ggtccgtgag ga
#tcgacctt  16140
tacaagatat aatttgtcca tatcgcaatg ttttctcggt ttgcgcgttc ct
#tttccagc  16200
gatgatagaa cgcgtaaatc ttatgatggt agttaccaaa gttttaatgc cg
#gcgaacgt  16260
gatttgccca cacctacccg ggactggtgt tctatttccc aacgcataac ca
#gcgagcgc  16320
gtgagggatg gatgtcttat tccaacgccc ggcgaggctt tggagacggc gg
#taaaggct  16380
ttatctgaaa agaccgacag cctaacatcg ccggttttac aaagtaccga aa
#gacacagt  16440
gttctgcttg gattacacca taataatgtt cctgaatcgt tggtggtctc gt
#gtatgtct  16500
aacgatgttc atgacgggtt tatgcagcgt tatatggaaa caattcaaag at
#gtttggat  16560
gacctgaaac tttctgggga tggactttgg tgggtttatg aaaatacata tt
#ggcagtat  16620
ctcaaataca ccacaggagc cgaggtaccg gtgacttcag agaaggtaaa ta
#aaaagtct  16680
aaatccacgg ttttgttgtt ttcatccgta gttgccaata aaccaatatc ca
#gacatcct  16740
tttaaatcta aagttataaa ttcggattac cggggaatat gtcaggagct ac
#gtgaggcg  16800
ttaggagctg tgcaaaagta tatgtatttt atgcgtccag atgatcctac aa
#accccagc  16860
ccggatacaa gaatacgtgt acaagaaatt gcggcttaca cggctactgg ct
#acgggtgg  16920
atgttatggt tcttggacgt tgtggacgcc agggtatgtc gccatctcaa ac
#ttcaattt  16980
cgacggattc gagggccgcg cgcgtctgtt attccagatg atttgcttag ac
#gacattta  17040
aaaacgggtc ctgcggtctc agcgggcaca ggagttgcgt ttattttagc ag
#caacaact  17100
gccagcgctc ttactgcgct tttgcgtatt agtgtattat ggcgaaagga ag
#agtggcgg  17160
gatggtttaa atggaaccgc agctgcaatt gttgcggcgg ttgaacttat ta
#cgcttttg  17220
caccaccatt ttcaatactt aattaatatg atgcttattg gatatgcatg tt
#ggggggat  17280
gggggattaa acgatcctta tatattaaag gcgctacgtg cccagggacg gt
#ttttatat  17340
tttgcgggtc agttggttag aacaatgtca acacacagtt gggttgtgtt ag
#agaccagc  17400
acccatatgt ggttttcccg ggccgtggcg cagagtattt tagcacatgg gg
#gtaaaccc  17460
acaaagtatt atgctcaggt tcttgccgcc agtaaacggt atactccgtt ac
#atttaaga  17520
cgtatatccg aaccatcgag tgtgtctgat cagccgtata ttcgttttaa tc
#gactggga  17580
tctccaatag ggacaggtat agggaatttg gaatgtgtct gtttaacggg aa
#attattta  17640
tctgacgacg taaatgcaag ttcgcatgta attaatacag aagcaccgtt aa
#acagtata  17700
gcacccgata caaatagaca gcggacttct cgcgttttag ttcgtccaga ca
#cgggtttg  17760
gatgtaactg tccgaaaaaa ccactgtttg gacataggcc atacggacgg ta
#gtccagtt  17820
gacccaacgt atcctgatca ttacacccgg ataaaggcgg aatatgaagg tc
#cggttcgg  17880
gatgaatcaa acacaatgtt tgaccaaaga tcggatttac gtcacataga aa
#cccaagca  17940
tctttaaatg atcacgtata tgaaaatata ccacccaagg aagtgggttt ta
#actcatct  18000
tcagacctgg atgtggatag ccttaacggg tacacttccg gagacatgca ta
#cagacgat  18060
gacttatcac cagattttat acccaacgac gttcccgtta gatgtaaaac ca
#cggttacg  18120
tttaggaaaa atacgcctaa gagtcatcat taagtacagc ggttaataga ta
#gttatgga  18180
ctaggcactt tggcggtcat ttccacaacc aggttaaaat tgggggattt gg
#gagaaaat  18240
agtctattgc gtattttctg ttcaataatt ggactgcgtt atttaaaggt ct
#gattggtt  18300
gattgggtta taaaaggaat tactccttta aattttactt aatgtaccca ca
#atatcaag  18360
tggtcgtttg tatttaacga ttattaccgg taccatggga gacttgtcat gt
#tggacaaa  18420
agtgccgggt tttacgttaa ccggcgaact tcagtactta aaacaagtgg at
#gatatttt  18480
aaggtatgga gttcggaaac gcgatcgaac aggaatcgga acgttatctt ta
#tttggaat  18540
gcaagctcga tacaatttgc gaaatgaatt tcctctttta actacaaagc gt
#gttttttg  18600
gagggccgtc gtggaagagt tgttatggtt tatccgcggg tcaaccgatt cc
#aaagaact  18660
cgccgctaaa gatatacaca tatgggatat atacggatcg agcaaatttc ta
#aataggaa  18720
tggcttccat aaaagacaca cgggggacct tggccccatt tacggcttcc ag
#tggagaca  18780
ttttggagcg gaatataaag actgtcaatc aaactattta cagcaaggaa tc
#gatcagct  18840
gcaaactgtt atagatacaa ttaaaacaaa cccagaaagc cgacgaatga tt
#atatcgtc  18900
ttggaatcca aaggatatcc ccttaatggt actacctcca tgtcacacgt ta
#tgtcagtt  18960
ttacgttgca aacggtgaat tatcctgcca agtataccag agatcggggg at
#atgggcct  19020
tggggtaccg ttcaacattg ctggatatgc acttcttacc tacatagtag cg
#catgttac  19080
aggacttaaa accggagatt taattcatac aatgggggat gcacatattt ac
#ttgaatca  19140
tatagatgct ttaaaagtgc agctagctcg atccccaaaa ccttttcctt gc
#cttaaaat  19200
tattcgaaat gtaacagata taaacgactt taaatgggac gattttcagc tt
#gatggata  19260
taatccacac ccccccctaa aaatggaaat ggctctttaa tggattttta aa
#tgttgtca  19320
agacagtaga tgtgttgcga atgtaataaa atgatataca cagacgcgtt tg
#gttggttt  19380
ctgtytatga acagcaacgg atgcataggg ttgcgataac tgcgataaga cc
#caatgtcc  19440
caaggataga tatcacacca attataactg ctacaacgga aaatgtagtg gc
#gtaggtag  19500
atgcatcgta ggtataaacg gccgaaaacg gagggaattt tttagggtaa cc
#atctagat  19560
gacacgaata ggtgataggt ccgtcgagtt ccgatgttgg acaagaactt tg
#catgttta  19620
caaaccgttt gttttgatca cacaccccag taatctcact gttttcgtgg tt
#gatgggag  19680
aatcgttaac ccaccatacg aaatgtacaa cgccacgtgg cacacatttt gc
#cgtacata  19740
ctatgtgtcc atcaataata cctatagaca cgttgggaaa tggatagacg tc
#aggggtaa  19800
cgacagcaga atatttcata ttagagacgc catcccgaat ccataaaaca tt
#acattgga  19860
tggctggggg tgggtaatcc atttgttttt gctgtggaat tcgtaccgcc ga
#aacataac  19920
taaataatcc attggcatat tcttgtattg catcggttat aaaatttttt cc
#gatgttac  19980
caaaccttga agtccaccga acacgtaccg agtgcggtgg ataatacttt ga
#tacgttac  20040
agtaggctgc gtatgtctgt ccggttaaga ctggatcgcc gacaacggta at
#atttggac  20100
gataatacgt tgtaactgta atactgtgtt ccgatatgac gttcttagtt tt
#tgtattaa  20160
cgactcgcca aatatacgtt ccctccgtgg tagcatccat agataaaatt gt
#tacagaaa  20220
aatcagacgt tgttttaaca tctggtatta cataattttc cttagcgtgt gt
#aaatatct  20280
cagggttgtt tattaagttt aaatcggcac tgttgctata taacataacc gg
#taaatctg  20340
gcatgcgtat taacgcattg cccagttgac ggtgcggatc tataaggtga cg
#cgtaaacc  20400
aaacttcaat atgaagatcg gggcgtataa gcgacttcca ccttgttata tt
#tgaacctt  20460
ccggatctaa agaatattgt tcatatgttt tttgttgctg cttaaaggcc gc
#ctgttgtc  20520
cggtcgttag acgcatgtaa caaggcatga taaatgtgtg aaaatagggt at
#ggattgta  20580
ttccgccgtg aacgcattgt atattttcaa atagaaaagg tggttgtgaa tg
#ttgggcgt  20640
tggctgcggg atcgggcttt cgggtagcgg ccgaggtggg cgcgacggcg gg
#atcgggat  20700
ttcgggaagc ggccgaggtg ggcgcgacgg cgggatcggg atttcgggaa gc
#ggccgagg  20760
tgggcgcgac ggcgggatcg ggatttcggg tagcggccga ggtgggcgcg ac
#ggcgggat  20820
cgggctttcg ggaagcggcc gaggtgggcg cgacggcggg atcgggcttt cg
#ggaagcgg  20880
ccgaggtggg cgcgacggcg ggatcgggct ttcgggaagc ggccgaggtg gg
#cgcgacgg  20940
cgggatcggg ctttcgggaa gcggccgagg tatataattc agttatactt ac
#gggtgtgg  21000
gttgagattc agtcgataat tgtatacacg cgatcgttaa aattaaattt at
#ttgtatcc  21060
gcttcatcct ggtttttatt gacacatcca cgctcccctt aaataaaaga tt
#aaaacacc  21120
caccgcggaa tttaaatgat ggaaacgttt ttttcgacat tgggaataat aa
#aaacggct  21180
tttgcaactt taaaaacttt atttatctcg attacgatac atatgtacca ca
#tagatagc  21240
atagatttat tataatataa acacacacgt gatatacttt agtgatatga ga
#tgccataa  21300
aacagtcaat aggtttaacg cttaatctca tcatctgaat acacgtcaaa cc
#cgccgcaa  21360
ctgttgatgt tagaattata atagctcccc atgaaatgcc ggcaaatgtt ac
#agctatac  21420
ccgtcaccga ggtcgttgta tataatacaa ttacccatag gttttttttt tc
#ttgatata  21480
aaacggcaaa accctgtaac ccaaatgcta taatatgacc tcctattgaa ac
#tgctaacg  21540
ttacttgtgt aagtttgata aaatgattta atttaattat atgtgagatt gc
#ccacatta  21600
atggggtaac tatatataac accgggggta taacagacat tatacgaatt cc
#tttaaaca  21660
cgcgtttaag ggtccgggaa ctttctctat ggtcacatac tctcccgcgg tc
#attttgtg  21720
tatatacaac ggcaaaacct aaatctgtat aagtgtttaa ttgcttatgg cg
#atttttac  21780
gatatataca cgtatcttgc aaatcggtgg cggcatcgac aattgaaact ag
#tgtgacaa  21840
tagatataca caatccaata agaacctcat atttactgac atacatatat aa
#aataacgg  21900
ttagtaaacc tcccaaccca gttcccaaca tcataacata aaaataaata tg
#cggtccat  21960
tgaatgtcgt aacaaagttg tagtaatgga tatgcacagc agccactgtt cc
#ggtaatcg  22020
cggatatgga aattcccagt aattctacaa atggaagatc ccgggatatt gg
#gcaaccaa  22080
ccgcccataa cacagcaaaa cccaacacga ccaccgtctg caaacatcgt cc
#caattttg  22140
ctaatgtgcg tagaaatttc acggatgttg gccataaccc cgaaacgacg at
#caacccca  22200
taatagttgc attgacggca gcttcgcaga cgtgatattg taaaattaac cc
#ggacgtga  22260
taacacttgc ttgtagtccc acgagaaaca accgcgatgc tgaggttatt gc
#acacgaat  22320
tacattcttg agggtttccg acacatcctt ggattgattg agcgcggatt aa
#ttctctgt  22380
ctaacacacc caggttttca tcatggacag ctctttcacc attcacggcc at
#gtcttaag  22440
tttaataatt caaaacagat aaaaatgtgt tcatctatgg tacacacaag tt
#tgtatgta  22500
aaatataagc aaaagttgca cttatttaac tgtacatatt acgtcagatt ca
#cgtgataa  22560
ttcagaataa tccagggttc ctgcagggtc cactggagga gccacacaat at
#tcgcgaat  22620
tccgattccc tcctgccatg tggtttcggg gagtttcccc cccattttat tt
#ccggtatt  22680
tttttcgttt ctttttgtta ataaattgcg tctttttttt aatggtggtt ca
#tccttcac  22740
agattccgtg ttcgcaaata attgcatcga ggttaatttt tctttaaggt ct
#ttgggact  22800
taagaacgtt gcataaaaaa aagaatgcac gggtgcggaa cgttggatat ac
#aatccaac  22860
catgggggag ttagttaagg cgagataaaa attaatataa cacgtctcat cc
#cgtgttaa  22920
cttaagattt tgtacggcag aacggaatcc actgtgtgtt tccaataata ct
#ccaaattc  22980
acgcatactc ccgctgccat aaacaacatt attaaggatc ctttttgaat tt
#gtgattga  23040
gcgtattaaa ttatatggtg taggcttgct tccgtttata tccaaggaaa ca
#ttaaatga  23100
gataaaacca cccccggcgg tctggatgta catatccgtg gctgttagaa tg
#aagcatgt  23160
tgtaaaccca aaagttttaa gtagtcgctg taaacgggtg aattgatcgc gt
#tttaagca  23220
aatgcttata tctggagtta gatttgggaa catcattgta taacaagcga gt
#tcacgttt  23280
tacaacttgt ttgtaacatt gtacttgatc atctggacca caatcacccg gg
#cgttgcca  23340
taccatcgtt tggataatac tccgctcggg gggttgtccg gtaaatttaa aa
#tataaccg  23400
tgttggggtc gacggatctt ttgtatggcg aaacgcgtca ataagcgagg ac
#cgtccctc  23460
cgttgccgcg agtacaacca ttctcggccc agtccaatta tactggtcaa ac
#atatttgc  23520
cggtatagga atatacagtt gttctgtttc caaactacag tgaataatta at
#ccttcgtc  23580
gctgaatatt aaaatagaat cccttagtct attaaccaga ggtgatatag ac
#gaaattaa  23640
accagtaagc gttttttccg ttaaaacagc tctggcgatt tctggggcgt ca
#aaacccgc  23700
atgcaattcc atgtccaaag catcgtctgt acgcgacctc aaatccataa tt
#tactactt  23760
aaaatgttta ctatagaaaa agtaatcata tgtaaacaca cgagtttcgt ta
#atatgttt  23820
gtttaacccg atccggtgac ttaagtacat aaacaggcat gatatttgaa ta
#gtacggcc  23880
catgggaggg aacatttcca cgtgttccaa tacagggggt gttccttaat ag
#ggactgtg  23940
caataaaata cgtaagaagt taccagattt gatgtaatgt ttgtcataaa aa
#atatgtac  24000
atcattatat acgtctgtaa ttaacacaag atcacatcga agaattactg aa
#gccgctgt  24060
gaaacctttc acaagacgat ataaacttgg ttaagtgtat tgatggggct ct
#ttggactg  24120
acacgcttta tccatgaaca taaactggtt aaacccagca tcatttcaac gc
#cacccgga  24180
gttttaaccc ccgtggcggt agacgtatgg aacgtcatgt acacattgtt gg
#aacgttta  24240
taccctgtgg gtaaacgcga gaatttacac ggaccatctg taacgataca tt
#gtcttgga  24300
gtcttattgc ggctattaac acaacggtca tactatccga tatttgtatt gg
#aacgttgt  24360
acagacggcc cattatcacg tggagccaag gcaattatgt cacgggccat ga
#accacgat  24420
gaaaggggaa cctcggactt aacccgtgtt ctactatcat ccaacacatg tt
#ctatcaag  24480
tataacaaaa catcggaaac atatgacagt gtgtttcgaa actcttccgc ga
#gttgtatt  24540
cctagcgaag aaaacaaatc ccaggatatg tttttggacg gttgtccacg ac
#aaactgac  24600
aagatgatct gcctgcgcga ccaaaacgta tgcagtctta cctctacaat gc
#catcccga  24660
ggacatccta accatcgatt atatcacaaa ttgtgtgcaa gtcttattag at
#ggatgggg  24720
tatgcatacg tcgaggcggt tgacattgag gcggacgagg catgtgcaaa ct
#tatttcat  24780
acgcgtacag tggctttggt ttatacgaca gatactgatt tactcttcat gg
#gctgtgat  24840
attttgttag atgcaattcc tatgtttgct ccagtagtac gatgtcgcga tt
#tgcttcaa  24900
tatttaggaa ttacataccc tgaatttttg gttgcctttg ttcgctgtca ga
#ccgatttg  24960
catacaagtg acaacctaaa atctgttcag caagttattc aggataccgg cc
#tgaaaatt  25020
ccacatcaaa tggacacttc aacgcgctcc cccacttacg actcgtggag ac
#atggcgag  25080
gttttcaaaa gtcttaccgt agccacgtcg ggtaaaacag aaaacggagt gt
#ccgtttcc  25140
aaatatgcat ctaaccgatc ggaggtgaca gtagacgcca gttgggcttt aa
#accttctg  25200
ccaccctcat cctccccatt ggataatttg gaacgcgcat ttgttgaaca ta
#taatcgcc  25260
gtggtaactc cattgacccg cggtcgccta aagttaatga aacgtgtaaa ta
#ttatgcaa  25320
aatacggcag acccatatat ggttattaac accttatatc ataacttaaa gg
#gggaaaaa  25380
atggctcgcc aatacgcacg tatttttaaa cagtttattc ctactccact cc
#cactaaac  25440
actgtattaa caaaatattg gaattaaaac acacataaga gcgacttaat gg
#ttcattgt  25500
tttattttgc tcgtatatac atgttataaa tcgtttatca ctgtgcccgc at
#aagatgta  25560
ctgtgtctct caaaaaaatt tgtgttttta tctgcaatca taaatgcaag tg
#gaaagtcc  25620
gaatcgggag gtggggtgtt aaatagtttt ggtacattaa tcgctgataa aa
#gcctgtcc  25680
gcgctgaatt tcacgtattg tgtaattgca tcgacgttca ccaaacgggt tt
#tgggtgca  25740
tgggatttta aaaacgcaca ctcgatttca acggcttccg aaaacagttg at
#gtattctg  25800
gtgatagcgg gtttttcggg tacatagtta ttgtatatac aacacgatgc gc
#tggtatgt  25860
atggcttcat ctcggcttat aaggtcgtta aattgacaag ttacaacaaa ta
#gtccgtta  25920
ttgcgtaaat atgcaatagc cgcgaacgat gatacaaaaa aaatgccctc ta
#taagaatc  25980
attagtatat atttttctgc aacggatggg ttgtcccgta ccttttcttc ca
#accattgt  26040
actttttgtt ggatcgacgg attattaata gtgacgttta cgtattgtac cc
#gcaacgat  26100
tcatcccctc tgaacaacat tagttgaatt tgactataga cacgcgcgtg ga
#caacctcg  26160
atgcactctt gttcaatgta gtaatggtga atatcctttt gggaaaagag tt
#gggttaga  26220
gagcccaaat taacatttac cagatcatct gccgccgata aaaatgtaaa aa
#taaatctg  26280
tagaatatta gttcatcttc cgttaaacag tccaagtatt gataatcatc tt
#caatgata  26340
aaatcgcttt ctaaccaacg attcgaaatg ctcagggcac gtaaattgtt ta
#tatctgga  26400
cactccggcc tgtaaaaaaa atgactgcaa tctttctgat ccattttgga at
#agtttccc  26460
gtgtaaattt ataaagcaca actggtacag gttaattcgc ctcccgcaaa ca
#gtccgctg  26520
ttcgtagctt tacgaatttt acagtagtac atacccgttt taaggccggc tt
#tataggca  26580
cgtataagca aattcattat tttggaggcg ggaattgtcc cgtctgggcg tt
#cctcaata  26640
aataaagtca ttgattgact ttggtcaata aatggcgccc tttctgcaca ca
#tatcaacg  26700
agatcctctt gctcatattc aaacgctgtt ttatatttta agagtgggtg ac
#tattagat  26760
aaacagccaa acgaacgtat tactgaccat tggtttttct caagtatgtt ta
#taacttcc  26820
agtcgttttt cttcacatga atacatatct cttagttcgt ccataaggtc ta
#agttgggt  26880
ctaagtaact cacccgaggt ggtgacctta ctaaacatat tattataaat tg
#gagagaaa  26940
ccctcactgc actccgttac ctgtgcagat gaaactgtgg gcattaacgc ta
#agaactgc  27000
gagttgtata acccataagc gcaaatatca tctcgcaggg tacaccatgg ta
#aatctaaa  27060
taacttatcg tagaaaaccc atcttggtgt aaccatccct tagcatattt ac
#tttcggta  27120
aaacccttaa acggggctaa gccgccaatc ttacacattt ccatgcttgt tt
#tcattgtc  27180
tcatacaaca ttaactccgc tatttgtaca tttaaccgtc tagctggttg gg
#aagttaaa  27240
tcaaatccta agcggagaca agttgtatgt aacccttgta tgccaatgcc aa
#gtgatcgg  27300
ttgtttttta cacctttaca tgatttttta catggaaagt tcccagccgc ca
#ggaccccg  27360
tttaaaaaaa taacagtcgt tcttgctgtc aattgaaggt cgtttaaatt aa
#atgacact  27420
gggcctttgg ataagcacgt tgtaagattt atgctggcaa gattacatac gc
#cgtgttga  27480
tgagcgtctg ccttttgaac aatttccgta cacaaatttg accccgtgat ag
#catttcct  27540
tgggtattca tatgataatt acgattacag gcatctttga acattaaaaa gg
#ggcttcct  27600
gttacagcag cactgcgtat gattgtgaat gcgatatctt gaatgggaac ag
#aagaaacg  27660
cctaatcctt ctctctctaa acgtaaatag gttgaagtga atgcctcccc gt
#gtaatgtt  27720
cgaaggatat cggctctgtt atcaaaaaga gtccactgaa cattactagc cc
#cttttaga  27780
tagcttaggt atctttcaaa aaataaatct ggggtccata aacaacaaaa ta
#tgttatca  27840
catcgaaata tttcatcacg aaccaacatt ccacgtgtgg ccaaaacagt tt
#gtagatcg  27900
acgtgccatg gttctatgta aacacaaact ccagttggtc gttcacaatc ac
#tgttaatt  27960
gccataacca tgcaatctaa aagttttaaa actgcaagaa gacctttcgt tt
#gattttcc  28020
gtaggtatta aattcagact ctgtagagaa attcccactc cacctcgact tt
#gtaatacc  28080
gttcccacat cgcctgtgat agctcgaaca gctctcccaa cagtgatgga tt
#ccgggtcc  28140
attaaataac aactggccgt tgccccggtc tctcgaccta aaaacatcat aa
#ccggtgta  28200
gccgggacaa ttttctgaca tgccaacgct gtgaaaaata cccgacagac at
#cagtccat  28260
gtataaccat catttattcc gggaataaga gttgcgattt taggcaggtt ta
#cgatttct  28320
gttgtcacgg tggccgccag tcttaaaaag aattggcaaa gcgactctaa tt
#taccttcc  28380
tctaacttag ttaaataaaa gtcttcgtac tttaaagcag actgtagtcc aa
#gggtagct  28440
aaagcggggt attgatcttt caaaaacggt tctaatatag cccgacgaat tt
#cgtccctc  28500
cgcccttcaa ttgcttggcg gactcgggga gttaaacaga gaattgggga ag
#tcaaccac  28560
gtttccatgg aaacggatcg taggttaata cggcaatgga taagttctcc ac
#aacatcgg  28620
tacactcgct catcttgtcg cgtcaccgcc ttaagttttg agacgatagt gc
#taatatac  28680
tccattaatt ccaccggtgt ggttgattcg ggcggaatga tgtattcctt gt
#agccatgt  28740
tgacataatc ggtttataat gtcatgaacc gtattaaaaa ttcttttgaa ct
#ccataacg  28800
gataacgtat ttaggctccg gaataaacct ttaaacccta aactcacagc tg
#agttagtt  28860
ctacaatatt gtagactccc ttatatatgg ttacgtacag cctgcccctc cc
#cagtatat  28920
aatatcacgc aaaacccacg ctatgttaaa ttcagtttat tttacataca tg
#ctttaata  28980
ataacattcg ttccatgtat ttgtaccccc ccacacaacc ccctctaacc aa
#atagttgg  29040
cacgttataa cctccgaacc gttccatgcg tcttgtataa cgcacagact ct
#gatggaat  29100
tgttccaatt aacgtatatg ccgcatacat gcaggataat tgtgtgggaa gg
#ccccgaaa  29160
atcgccggtc cattgataca atcgctgtct agccaagttc caatttactc ct
#gtaatttc  29220
gccaatacta catcgagggc ttgtcgggtc attggataac tgcacaagcg gc
#aacgccct  29280
tgtgttatat ggctggtggg tatttgcaac cccttcagtc ccccaggcgg ca
#ttttcagc  29340
tcgtatgcgt cctaacagga agccaatacc acgaccaaaa cattgttcgt tt
#agttggct  29400
taatgcaaga tgcagtctta caccttctcg ttggcgtcgc tgtgtatata ca
#aaaaccaa  29460
gaacacatgc ttcagtccgt ccgcggaaag atgtaaatct ttgtcaacgt cc
#caaaatac  29520
gcaggccggg atgttggctg tgaccctgcg agttgaagtt ttgtctgtac gt
#gcagcttc  29580
ttggggacct ttggccacgg cggttatatt gcataaatta tcctgaatgg ta
#tattccag  29640
cagggaccca aaaaaactta taaatcgatg tggaaataca tgacattgta cc
#atcgcacg  29700
taaacactcc gaaaacctta tgagccgcgt ttccatacga ctgcatccat ag
#gcagaaac  29760
aattgctgtt ctgttggcat ccgctgcctg tttatccgta tattcttctg cc
#cggcatgc  29820
ggcgatgaaa cttaatgacg ttacatatgc tctaagcccc ccaccttctc ca
#acggtcca  29880
aggagccgtg caggcattga ataggtttcg taaaccctct agtagtacat cg
#gggtcacg  29940
tccagcctgt gtaagtgtat tagcttctcc aatcatgtca gatggatgac ga
#aggattaa  30000
gacgattgac ccagcatgct caatgtccgg acgaaaaaaa tcggttaatg ac
#acttgttg  30060
gattagctgt gtcgttgatt taaaattatt taacgggagt ctaatggtaa ct
#tgcgggtt  30120
accaattgaa gttggattta tttgaatgtt gttcatacga ttaataacaa tt
#gaacgggg  30180
ggttacttga atagacgcgg tttctgtacg ttttggtggt acatgtatcg gt
#tgtttgtt  30240
cagacctcca aagcgagggc caattgttaa atcgcgactc caatttccga ag
#aagcccgg  30300
agcataagtc atatgaagcc cgttccctat ttgaataaaa cggttatttc ct
#aaaagact  30360
gatattagtt ccacatagcg tttgttcgtt taaagtaaaa tgcgagttgg tt
#ggttgact  30420
ccccatagct gaggggttaa attcacacaa tgcaatcgtg acgtggtact at
#ctgaaatg  30480
ttgcctgggg tatgtgtaca cattatacag tcgtagtacc gtttatataa tg
#ttaggtag  30540
gaggagccta taaaaatatt ttgattggcg ttaaaaggtt cttcaactta cc
#gtgacgtc  30600
ctttttatta acatgcgttt ttattgatgt tacatttatg tcttttcatt cc
#ggacggat  30660
gtagcttttt catatcacgt tataaagtta agtcagcgta gaatatacca tg
#gaagaacc  30720
aatttgttat gatacacaaa aacttttgga tgatttaagt aacttgaaag ta
#caagaagc  30780
ggacaacgaa agaccatggt caccagagaa aacagaaatc gccagagtta ag
#gtagttaa  30840
gtttttacga tctacccaga aaattccagc taaacatttt attcagatat gg
#gaacccct  30900
gcattctaat atctgttttg tatattccaa tacatttttg gcggaggctg ct
#ttcacggc  30960
cgaaaattta cccggactgt tgttttggag actagatcta gactggacga ta
#gaggagcc  31020
aggtaatagc ttaaaaattt taacccagct atcaagtgta gtacaagatt cc
#gagacgtt  31080
acatcgttta tcggccaata aattacgaac ctcgtctaaa tttggacccg tt
#tcgataca  31140
cttcattata acggactgga taaatatgta cgaggtcgcc ttaaaggatg ca
#acaacagc  31200
cattgaatca ccattcactc acgctcgtat tggaatgttg gaaagcgcca tt
#gcagcttt  31260
aacacaacat aaatttgcga tcatttacga tatgccattt gttcaagagg gg
#attcgtgt  31320
tttaacacaa tatgcaggat ggcttcttcc gtttaatgtt atgtggaatc ag
#attcaaaa  31380
tagctcactc actcctctaa cacgagccct ttttataatc tgtatgattg at
#gaatatct  31440
cacggaaacg ccagtacata gcatatcaga attatttgca gatactgtaa at
#ttaattaa  31500
agatgaggcg ttcgtatcca tcgaagaagc ggtaacgaat ccacgaacgg tg
#cacgagtc  31560
acgaatttcc tcagctctgg cttatcgaga cccttatgtt tttgagacat cc
#ccgggaat  31620
gcttgctagg agacttagat tagacaatgg tatatgggaa agcaacctct ta
#tcgttgtc  31680
cayccccgga attcatattg aggcgctgtt acatttacta aactccgacc cg
#gaagcgga  31740
aaccacatct ggaagtaatg tagcagaaca cacccgtggc atttgggaaa ag
#gttcaggc  31800
tagtacatcg cctagtatgt taataagcac ccttgccgaa tccgggttta ca
#agattttc  31860
atgcaaattg ctacgtcggt ttattgctca ccacacactc gccggtttta tt
#cacggaag  31920
cgttgtagca gacgagcata ttacagattt ccaacaaaca ctaggatgtc tc
#gctttagt  31980
gggtggactg gcataccaat tagtggaaac gtacgctcct actaccgagt at
#gtgttaac  32040
atatacacgg acagtaaacg agaccgaaaa acggtatgaa acgctattac cc
#gccttagg  32100
attaccaccg ggaggcctgg gacaaattat gcggcgctgt tttgctccac ga
#ccccttat  32160
tgaaagtata caagcgacac gcgtaatact acttaatgaa atttcacatg ca
#gaagctag  32220
agaggcaaca tattttaagc aaacacataa tcaatcctca ggtgcgttat ta
#ccacaagc  32280
aggacaaagt gccgtacgcg aagccgtact aacctggttt gacctacgta tg
#gattcaag  32340
atggggtatt actcccccgg tggatgtggg tatgacacct cctatttgtg tt
#gatccacc  32400
ggctacaggg ttggaagctg tcatgataac agaagcacta aagattgcat at
#cctaccga  32460
atataatcgc tctagcgtgt ttgtggaacc gtcgtttgtg ccttatatta tt
#gcaacaag  32520
cacgcttgat gccctttcgg caacaatagc tttgtctttt gatacacggg ga
#atacagca  32580
agccttgtct attcttcagt gggctcgcga ttatggatcc ggaaccgtgc cc
#aatgcaga  32640
tggatatcgc acaaaactat ctgctcttat aacaatatta gaacctttta cc
#cgtacaca  32700
ccccccagta cttttaccat ctcacgtttc tactatagat tcccttatat gc
#gaacttca  32760
tcggactgtt ggcattgccg ttgacctgct tccccagcac gtccgtcctt tg
#gttcctga  32820
ccgtccttct attacaaata gcgttttttt agcaactctc tattatgatg aa
#ctttacgg  32880
tcgttggacc cgactggata aaacatcgca ggcgttggtt gaaaatttta ca
#tccaacgc  32940
gttagtggtt tctcggtaca tgttaatgtt acaaaaattt tttgcgtgtc gt
#ttttatcc  33000
aacgccagat cttcaggctg ttggtatctg taacccaaag gttgaacgcg at
#gaacaatt  33060
tggggtatgg cgtttaaacg atcttgctga tgcggttggt catattgttg gg
#acaataca  33120
aggaatccga acgcaaatga gagtgggaat atccagcctg cgcacaatta tg
#gccgatgc  33180
ttcctcagcc cttagggaat gtgaaaattt aatgactaaa acctccactt ct
#gctattgg  33240
gcctcttttt tcaacgatgg cttcccggta tgcacggttt acacaggatc aa
#atggacat  33300
tttaatgcgt gttgacaaac taacaacagg agaaaatata cccggtcttg ca
#aatgtaga  33360
gattttttta aataggtggg aacgaatagc aacagcttgt aggcatgcca cg
#gcagtccc  33420
gtcggccgaa tctattgcaa ccgtgtgtaa tgaattgagg cgcggtttaa aa
#aatataca  33480
agaggatcgt gtaaatgccc caacctcata tatgagtcac gcccgaaatc tg
#gaagatca  33540
caaggcagca gtttcattcg ttatggactc caggcaacag tttattgtgg at
#tctggacc  33600
tcagatgggc gcggttttaa cttcacaatg taatatagga acatgggaga at
#gtaaatgc  33660
aacgttttta cacgacaacg ttaaaataac gacaacggtc agagacgtaa tt
#tcagaggc  33720
tccgacgctg ataataggac aaagatggct tcgtccagat gagattttat ct
#aatgtaga  33780
tttgcgtctt ggcgtacccg ggaatacaag tgggagtgac ccttaatata aa
#acaggcgt  33840
gtttatgtac attaaagtat ttgtggtttt tattgactgg gcgtttcgtt tg
#tataacgc  33900
tgttgttgct agtattttca taacctccta ggtttttgga gctacacgtg ct
#tattcaac  33960
gctctttggg atttgaatca tcgtaaacgt agcgtcccta ccagttgagc gc
#gtaatttt  34020
cgtaagcaat aaaatggata taattccgcc tatagctgtc actgttgcgg ga
#gtgggaag  34080
ccgtaatcaa tttgacggtg ccctgggacc ggcgtcaggt ctgtcatgtt ta
#agaacatc  34140
tttatcgttt ttgcatatga catatgcgca tggaattaat gcaaccctgt ca
#tcagacat  34200
gattgatgga tgtttacaag agggtgcagc atggactacg gatctgtcta at
#atggggag  34260
gggtgtccca gatatgtgtg ctcttgttga tctccccaat cgaatttcat at
#attaaact  34320
gggggacact accagtacgt gctgcgtttt gtctagaata tacggcgata gc
#catttttt  34380
taccgttcca gacgagggtt ttatgtgcac acaaattccc gctagagcgt tt
#ttcgatga  34440
tgtgtggatg ggacgtgaag agtcgtatac aattataact gtagactcaa cg
#ggaatggc  34500
catctatcgt cagggaaaca tatcttttat ttttgatcca catggccatg gg
#actatagg  34560
acaggctgta gttgttcggg tgaataccac ggatgtgtac tcttatatcg ca
#tcggagta  34620
tacccaccgc cccgataacg tagaatccca atgggccgct gcattagttt tt
#tttgtcac  34680
cgcaaacgac ggtcccgtaa gcgaagaagc gctatcttcg gcagtaacgc tt
#atatacgg  34740
aagctgtgat acatatttta cagatgaaca atattgcgaa aaactggtta ca
#gctcaaca  34800
tccgttgctt ctttcacctc ctaattccac gacaattgtg cttaataaat cg
#tctatagt  34860
acctcttcac caaaacgttg gtgaaagtgt atccttggaa gcaaccctac at
#tcaacgtt  34920
aaccaacacg gttgcactgg accctagatg tagttacagc gaggttgatc ct
#tggcatgc  34980
ggttctagaa acaacctcga ctgggtctgg cgttttggat tgtcgtcgta ga
#cgccgtcc  35040
ttcatggact cctccttcaa gcgaggaaaa tttagcttgt atcgacgatg gc
#ttggtaaa  35100
taatacacat tccacggata atttacataa acccgctaaa aaggttctca aa
#tttaaacc  35160
aactgtagac gtgccggata aaacacaagt ggcacatgta ttaccccgcc ta
#cgagaagt  35220
tgctaacacc ccagacgttg tgttaaatgt atccaatgta gatacgcctg aa
#tccagtcc  35280
cactttttca cggaacatga atgtaggaag cagtttgaaa gatcggaagc ca
#tttctatt  35340
tgaacagagt ggtgatgtca acatggttgt cgaaaaacta ctacaacatg gg
#catgaaat  35400
tagcaatgga tacgtacaaa atgcggtggg tacgttggat actgttatta cc
#ggtcatac  35460
aaatgttccc atttgggtaa caaggccctt ggtcatgcca gacgaaaagg at
#ccattgga  35520
gctttttatt aacctcacca ttttgcgttt aacgggattt gtggtggaaa at
#ggaacacg  35580
tacacatcat ggtgctacaa gcgttgtatc agactttata ggtccccttg gg
#gaaatttt  35640
aacaggattt ccctccgccg cggaacttat acgcgttaca agtttgatat ta
#acaaacat  35700
gccgggggcg gaatatgcta ttaaaactgt tctccggaaa aaatgtacaa tt
#ggcatgct  35760
cattatcgct aagtttggtc tagttgccat gcgggttcag gatacaaccg gc
#gctttaca  35820
tgccgaacta gatgtgttag aagcggatct aggaggttcg tcgcccatag ac
#ctctattc  35880
tagactgtcg acaggtctta taagtatact aaattcgcct attatttctc at
#cccggact  35940
ttttgccgag cttattccaa cccgtacagg gtccctgtct gaacgaatac gt
#cttctttg  36000
tgaattagtc tcggcccggg agacacgcta tatgcgtgaa cacaccgcgc tt
#gtttctag  36060
tgtaaaggct ttagagaatg cattacggtc tacccgcaat aaaattgatg cc
#attcaaat  36120
accagaagtt ccccaggaac ccccggaaga aaccgacatt ccacccgaag ag
#ttaattcg  36180
gcgtgtatat gagatacgat ccgaagttac aatgctattg acctcggctg tt
#acagaata  36240
cttcacccgc ggagtgttat atagcacacg ggccttgatc gctgaacaat cc
#cctaggcg  36300
ttttcgggtc gcgaccgcaa gtacggcacc cattcaacgg cttttagatt ct
#cttccgga  36360
attcgacgct aaattaacgg caatcatatc gtccctgtct atacaccctc ct
#cctgagac  36420
tatacaaaat ctccccgtcg tatctctgtt aaaagagctt attaaagaag gg
#gaagattt  36480
aaacacagac acggctctcg tatcgtggtt atctgtagtc ggggaagctc aa
#accgcagg  36540
ttacttatcc agacgagagt tcgatgaatt atcacgtaca attaaaacca tt
#aatacacg  36600
cgcaacgcaa cgggcttccg cggaagcaga gttgtcttgc tttaatacgc ta
#agcgcggc  36660
cgtagaccaa gccgtaaagg actatgaaac atataacaat ggtgaggtca ag
#tatcctga  36720
aataacacgg gatgatttat tagcaacaat tgtacgtgct acagacgatt tg
#gtgcgaca  36780
gataaaaatt ttaagtgatc caatgatcca atccggttta caaccttcga tt
#aaaagacg  36840
attggaaaca aggcttaaag aggttcagac gtatgcaaac gaggcccgaa cc
#acacagga  36900
cacaataaag agtcgaaaac aggcggcata taataaactc ggggggttac tt
#cgcccggt  36960
aaccggtttt gtgggactta gggctgcagt agatttatta ccggaacttg ct
#tctgagtt  37020
agatgtccaa ggagccctgg taaatctcag gaccaaagtc ttagaggcgc cg
#gtagagat  37080
ccgttctcaa cttacgggtg atttctgggc gttatttaac caatatcgag ac
#attttaga  37140
acatcccgga aacgcacgca catctgtctt aggaggactg ggagcttgtt tt
#acagctat  37200
tatcgaaatt gtgccgatac ctacggagta tagaccatca ttgcttgcgt tt
#tttggtga  37260
cgtggcagat gtgcttgcat ccgacatcgc gaccgtatct actaacccgg aa
#agtgagtc  37320
cgccataaac gctgttgttg caactcttag taaagcgacg ttagtttcat ct
#acagtgcc  37380
agccttatcc tttgtgttgt cgttatataa aaaatatcag gctttacaac aa
#gaaattac  37440
gaatacccat aagttgactg aattacaaaa acaacttgga gatgacttct cc
#accctagc  37500
tgtctcatct ggacacttga agtttatatc atcttcaaat gtagatgatt at
#gaaataaa  37560
cgatgcgata ttatcaatac aaacaaatgt gcacgccctg atggatacgg tt
#aaacttgt  37620
tgaagttgaa ctgcaaaagc taccccccca ttgtattgct gggacatcta cc
#ttatctcg  37680
agtagtaaag gatcttcata aactcgtcac aatggcacat gagaagaagg aa
#caggcaaa  37740
agtgttaatt accgattgtg aacgtgcaca taaacaacaa acgactcggg tt
#ttgtatga  37800
gcgttggaca cgtgatatta tagcatgtct ggaggcaatg gaaacgcgcc at
#gtatttaa  37860
cgggacagaa ctggcacggt tgcgagatat ggccgctgcg ggagggtttg at
#atacacgc  37920
agtttaccca caagcacgtc aggttgtagc ggcatgtgaa actacagccg tt
#acggcatt  37980
agatacygtg tttcgccaca atccacatac ccccgaaaat acaaatattc cc
#ccaccttt  38040
ggctttgtta agagggttaa catggtttga tgatttttcg attacggctc cc
#gtattcac  38100
cgttatgttt ccaggtgtta gtattgaagg actccttctg cttatgcgta tt
#cgcgcggt  38160
tgtgttatta tccgccgata cgtctattaa tggaatacct aactaccgag at
#atgatatt  38220
acgaacctcg ggggatctat tacaaatacc cgcattggct gggtatgttg at
#ttttacac  38280
acggtcttat gatcagttta taaccgaaag tgtaacgtta agtgaactta ga
#gcagacat  38340
cagacaggct gccggggcta aacttacaga agcaaataag gctttggagg aa
#gtaactca  38400
tgttcgggca cacgaaacgg ctaaacttgc acttaaagaa ggtgtcttca tt
#acattacc  38460
aagcgaaggt ttattgattc gggctataga gtattttaca actttcgatc at
#aaacgatt  38520
tataggaacg gcatatgaaa gagttttaca aacaatggta gaccgcgatc ta
#aaggaggc  38580
caacgcagag cttgcacagt ttcgtatggt gtgtcaggca acaaagaacc gt
#gcaataca  38640
aattttacaa aacattgttg atactgctaa tgccactgag caacaagaag ac
#gtggattt  38700
cactaacctg aagacgttat taaaactaac cccccctccc aaaacaattg ca
#ttggccat  38760
tgatagatct acttccgttc aggacattgt cacgcagttt gcattgctgt ta
#gggcgtct  38820
ggaagaagaa actggtacgt tggacattca ggcggttgac tggatgtacc aa
#gctcgcaa  38880
tattattgac tcccatccac taagtgtgcg tatagacggt accggccccc tg
#catactta  38940
taaagatagg gtggataaac tttatgcgtt acggactaaa ttagatctcc ta
#cgacgacg  39000
aatagaaacc ggtgaggtta cgtgggacga tgcatggaca acatttaaaa ga
#gaaacggg  39060
ggatatgttg gcatcggggg acacgtacgc tacttccgta gatagtataa ag
#gcactcca  39120
ggcatcggcg tctgtggttg acatgctttg ttccgaaccc gaattttttt ta
#ttgcckgt  39180
ggaaacgaaa aaccgtctcc aaaaaaagca acaagaacgt aaaacggcgt tg
#gatgttgt  39240
gttgcaaaaa caaagacagt ttgaagagac cgcgtctcgc ttacgagctt ta
#attgaacg  39300
tattccaacg gagagtgacc atgacgttct tcgtatgtta ttacatgatt tc
#gatcaatt  39360
tacacatttg cctatatgga taaaaacaca gtatatgaca tttcgaaatt ta
#ctcatggt  39420
acggttaggc ttgtatgcaa gttatgctga gatttttcca cccgcgtctc ca
#aacggagt  39480
gtttgctcct attcccgcca tgtcgggtgt atgtctagaa gaccaatccc ga
#tgcattcg  39540
cgcgcgggtg gccgcgttta tgggggaggc gtctgtggtg caaacgttta gg
#gaagccag  39600
atcttctata gacgctttgt ttggaaaaaa tttaaccttt tacttggata ct
#gatggggt  39660
tccacttcga tatagagtgt gttataaatc agttggggtt aaacttggaa cc
#atgctatg  39720
cagtcagggt ggattatctt tacgaccggc acttcccgat gaaggtattg tg
#gaagaaac  39780
tacactatcg gcattacgcg tggccaatga ggtcaatgag ctacgcattg aa
#tacgaatc  39840
cgctataaaa tccgggtttt ctgccttttc cacctttgtt aggcatcgcc ac
#gccgaatg  39900
gggtaaaacc aacgcacgca gagccattgc agagatatac gccggcctta ta
#acaacaac  39960
attgacacga caatacgggg ttcattggga caagcttatt tattcttttg aa
#aaacacca  40020
cctaacttct gtaatgggca atggactaac taaaccaatc cagagaaggg gt
#gatgtacg  40080
cgtattagag ttaaccctat ctgatattgt aactattttg gttgccacaa cc
#ccggtaca  40140
tcttctcaat tttgctagat tggatttaat taaacagcat gagtatatgg cc
#cgtaccct  40200
cagacccgta atcgaggccg catttagagg tcgtttactc gttcgctcat tg
#gatggaga  40260
cccgaaaggc aatgcccggg ccttttttaa tgccgcccca tccaaacata aa
#ctcccgtt  40320
agctcttgga tcaaaccagg atcctaccgg cgggagaata tttgcatttc gg
#atggcaga  40380
ttggaaactt gttaaaatgc cacagaaaat aacggatcct tttgcgccat gg
#caactttc  40440
cccccccccc ggggtaaagg ccaatgtcga tgcagttacc cgtataatgg ca
#acagatcg  40500
tcttgcgacc attactgtac ttgggcgcat gtgtctcccg ccaatttcct ta
#gtgtcaat  40560
gtggaatacg ctgcaaccgg aggaattcgc atacagaaca caagatgatg tg
#gacattat  40620
agttgatgcg agactggatt tgtcatccac gcttaatgca agatttgata cc
#gctcccag  40680
caataccacg ttagagtgga atacagaccg taaagtaatt acagatgctt at
#attcaaac  40740
cggggcaacg acagttttta cagtaacggg ggcggcacca actcacgttt ct
#aatgtaac  40800
agcgtttgac atagcaacta cggctatttt atttggggct cctttggtta tt
#gccatgga  40860
acttacatcc gttttttcac aaaattccgg acttactttg gggttaaaat ta
#ttcgattc  40920
ccggcatatg gctacagatt cgggtatatc ctcagccgta tctcccgata tt
#gtttcttg  40980
ggggttacgt ttactgcata tggatcccca cccaattgaa aatgcatgtt ta
#attgtcca  41040
actagaaaaa ctgtccgcgc tcattgcaaa caaacctctt acaaacaatc cc
#ccgtgttt  41100
actgctattg gacgaacata tgaatccctc ttatgtttta tgggaacgaa aa
#gactcgat  41160
tccagctccg gattatgtgg tcttttgggg gccagaatct cttattgatt tg
#ccgtacat  41220
cgactccgat gaggactctt tcccctcgtg tcccgatgat ccattttact cg
#caaattat  41280
tgccggttat gcgccccaag gccccccaaa cctcgacaca actgattttt ac
#ccaacgga  41340
gccactattt aagtctcccg ttcaagttgt tagaagttcc aaatgtaaaa aa
#atgcccgt  41400
ccagcccgtc cagcccgtcc agcccgcgca gcccgtccag cccgcgcagc cc
#gcgcagcc  41460
cgtccagccc gcgcagcccg tccagcccgc gcagcccata gaaccgggca ca
#caaatagt  41520
ggtacaaaat tttaagaaac cccaaagcgt aaaaacaacc cttagccaaa aa
#gatattcc  41580
cttgtatgtg gaaactgaat cagaaacggc tgtgcttata cctaagcaat ta
#accacctc  41640
cattaaaaca accgtttgta aaagtattac cccaccaaat aaccaattgt cg
#gattggaa  41700
aaataatcca cagcaaaacc aaacgttaaa ccaagcgttc aataaaccaa ta
#cttgagat  41760
tacctccatt ccgacagatg actcgatatc ttaccggact tggattgaaa aa
#tcaaatca  41820
aacacaaaaa cggcatcaaa atgaccctcg aatgtataac tccaaaacag ta
#ttccaccc  41880
tgtaaataac caattacctt cttgggttga cacggcagcc gatgcccccc aa
#acggacct  41940
attgacaaac tataaaacaa gacagccgtc gccaaacttt ccgcgggacg ta
#cacacatg  42000
gggcgtatct tctaacccgt ttaactcacc gaacagagac ctatatgaaa gt
#gattttag  42060
tgaaccttct gacggctata gcagtgagag tgaaaattct atcgtactaa gt
#ctcgacga  42120
acatcggtca tgtcgcgttc ctaggcacgt acgtgttgtt aatgccgatg ta
#gtcaccgg  42180
tcgacgttat gtccgaggga ccgccttggg agcactggcc ctgttaagcc ag
#gcatgtcg  42240
gcgtatgatc gacaacgtta gatatacacg taaactttta atggaccaca cg
#gaagatat  42300
atttcaaggc ctggggtatg ttaaattgtt attagatgga acatatatat aa
#agtagcgc  42360
ctattaaaga aaaaaaaaca acgattattt tctgtgtatt tttatttaca cc
#ctacgact  42420
tcttgaagcg tttccagatt gtcccgtgtg ggacaaggtc tgtcccttac cc
#ccctgggg  42480
ggtattttgg gttgggggcg gggtagactg tggcacgcct tgggccgcgg gc
#ggtgatcc  42540
ggttgttggc tggacagtgc ttgactgtgc tccctgttgc ggttgttgtc ca
#gaagaccc  42600
cgacaccacg tgttgctgtt gtccaacgga tgccgacgtc gtttgaggtg gg
#gggtgttg  42660
cggggatgat cccgaaaacg ccaacgcggc gggctgttgt aaagcagact ga
#tcggcgct  42720
ctgtgttttt tgcggcaata tagtaggccc cgagattccc aaactcatgg at
#ggatttgg  42780
gggttgtggt cgtataatac gcgggttaaa cgtacgtttt aagccaaccg tt
#ggtcttaa  42840
ccatgtcata gggtcagtct cggcaaacat ggccgttcgg cgtatcgtat tt
#gcattatg  42900
gttagcgcgt gcacgcgcgg cactggccgc ggctcccacg gtgtaaatgc tt
#ctggcatc  42960
agcgatgtcc acacggtgac caggttgcaa aggtccactg gcgtttaaaa gt
#cgtattaa  43020
agcaacgggg gtgtaagccg caattgcttc caccgaaaat gtggtggggt tg
#ctgggatc  43080
aaagactaca cgagacgatg cgggttgtgt catcgtttat tagtttacgg ga
#caatcgat  43140
aacagcatac acgtacatct gcgcaggata tgtacggaaa ggcaatttat tt
#ccagaaaa  43200
gcaccgcccc taatacaact accagtacaa ttacaacgaa cagggcatat gt
#cacgttag  43260
ctacgggtag agcaagtttc cagacacgcg tagtttgggt atcgggtaac gc
#aggtttaa  43320
tgtcactttg catttgaaca gacgtgtttg gacttccgtt ctcgggtggg ga
#tctgaatg  43380
aaggccgcca gcgtatatat tcatccaaat tattgccagt ttccttatac at
#gtatgcat  43440
ccgtggcgcg ggccataagt ttaatggtgc gagatggatc ttccggtccc at
#aaaacgaa  43500
aggataactg aacatatggc attcgcacaa agcagttcac ccacattaaa gc
#ctggagag  43560
gtcggcggtc aataccccca cctcgtttaa ttgattccaa agcagatagg tt
#gataccgg  43620
tacttaacgt tgaactaaga atcacgttat tactgtcaat ggacacttca gc
#cactggtg  43680
cgttagtcgg acgaaaaaaa aaaccttgaa atagcacaga cacccccgta tt
#ttgaattt  43740
ttatgtaagg gtcacaatct acttgcgccc aattcgccat taaacgcata at
#atactcta  43800
ccggaaaggc ttcggatacg ttgtcttcgc cgttaaactg aaaaacacaa cg
#ggcggggg  43860
ggcgttgtgg atcaaatatt ggaagatccc catcgcaaca ttgaagagcg ct
#tggtacca  43920
ccaaccgaat acgttgtaaa agattatctc cgcaacccct cctgcgttca ct
#ccgtacat  43980
acgttctccg tgacatattg atctaaggtt gcaaaccaag gcacacgcgt ga
#agtattta  44040
gaccatttat cgtgggatat aggaggagtt tggagtgatc caccccctga cg
#acttatta  44100
atgcgtttat tttccccatg tattaagcat ccttcaatat ttcatgcaaa tc
#tagaaatt  44160
tggccatgac tcccgcaaag cgttcacggc gacgggtcac gctggcacta tg
#ttcacatg  44220
gaacaacata agcagatttt tctgaatcgt tactttcttt atgttttaaa ac
#ggacgcca  44280
ggcgactggt aaatgatata taatttaatt gagcgtcagt tgtaggtaga at
#tgcttcta  44340
tttccggggg aattaaattt tcaaaccaaa cggaaagagt aaaggtgcta tc
#agcaggaa  44400
aatactttga ctccagtgca tcgatattta atagattaac atcggtgtct gt
#aattaaat  44460
cgcgggccct catcccagag atggatcggg tagaatcaga agaacccatg ga
#tggattcg  44520
aatcgcccgt attctccgaa aatacatctt ctaattccgg atggtgttcc ga
#cgcatttt  44580
ccgattcgta catcgcttat aatccagccc ttctgctaaa aaacgatttg tt
#attttcag  44640
aattgttatt tgcctcccac ttaataaatg ttccccgtgc aatagaaaac aa
#cgtcactt  44700
atgaggcctc ttcggcggta ggtgtggata atgaaatgac ctcaagtacc ac
#tgaattta  44760
tagaagaaat tggagacgtt ttggcgttag acagagcctg tttggtctgt ag
#aacgcttg  44820
atttgtataa acgtaaattt ggactgacac cggaatgggt tgcggactac gc
#catgttat  44880
gtatgaaaag tctggcatcc ccgccctgtg cagttgtcac ttttagcgct gc
#ctttgaat  44940
ttgtgtatct tatggatcgt tactacctgt gccgttataa cgttactttg gt
#tgggtcct  45000
ttgccaggcg cacgctttcc ctgttagata tacaaagaca tttttttttg ca
#tgtatgtt  45060
ttcgtaccga tggagggtta ccaggtatac gaccgccccc cggtaaggaa at
#ggccaaca  45120
aagtaagata ttccaattac tccttttttg tacaggcggt agttagggct gc
#attactat  45180
cgatcagcac gtctcgttta gacgaaaccg aaacgcgtaa gtcattttac tt
#taatcagg  45240
acggactgac tggaggccct caacctttag cggccgcctt ggctaattgg aa
#agattgcg  45300
cgcggatggt tgactgttca tcatcggaac atcgcacaag tgggatgatt ac
#ctgcgcgg  45360
aacgtgcatt aaaagaggat atagagtttg aagatatatt aatagacaaa ct
#taaaaaat  45420
cgtcttacgt agaagcagct tggggttacg cagacttggc tttattatta ct
#gagtgggg  45480
ttgctacttg gaatgtagac gagcgtacaa attgtgctat agaaactcgc gt
#tggatgtg  45540
ttaaatcata ctggcaggcg aaccggattg aaaactccag ggacgttcca aa
#acaatttt  45600
ccaaatttac gagcgaggat gcctgtcccg aagtagcatt tgggcctatt tt
#gttaacta  45660
ccttaaaaaa cgcaaagtgc cgtggtcgca cgaataccga atgcatgtta tg
#ttgtttat  45720
taaccatagg gcactattgg atcgctttgc ggcagtttaa aagggatata tt
#agcatact  45780
cagcaaataa cacaagttta tttgactgta tcgaacctgt aatcaatgca tg
#gagcctag  45840
ataaccccat taaacttaaa tttccattta atgatgaggg tcgattcata ac
#cattgtaa  45900
aagcagcagg ttccgaggcc gtatataaac atttattttg cgatctccta tg
#cgctctct  45960
cggaattaca gacaaaccct aaaattttat ttgcccatcc tacaaccgcg ga
#taaggaag  46020
tgttggagtt atataaagcc caactggctg cacaaaacag atttgaaggt cg
#tgtatgtg  46080
ctggcctgtg gacattggcg tatgcattta aagcctacca gatttttcca cg
#caaaccaa  46140
ccgccaatgc cgcattcata cgagatggag gacttatgct tcgacgacat gc
#aatatcgc  46200
tggtctccct cgaacacacc ctatcgaagt atgtctaggc gatataaatc cg
#tatctcgg  46260
agcgggcctt cgatgcgtgt acgctccaga acgccatgcc gccgtcaaac ca
#ttcgagga  46320
aaacttatgt caaaggagcg gtctgtgtac cgccattatt ttaattacat cg
#caaggtcc  46380
cccccagaag aactagctac cgttagaggc ttaatcgtgc caattattaa ga
#cgacccct  46440
gtcacccttc cgtttaactt gggtcagaca gtggcggata actgcctgtc gt
#tatccgga  46500
atgggttatc atttaggtct cggaggttat tgtccgacat gcactgcatc tg
#gagaaccg  46560
cgtctatgtc gaaccgatcg ggcggctctg atactagcat atgttcagca gc
#ttaacaac  46620
atatacgaat atcgtgtgtt tcttgcatcc attttggcgc tatcagaccg ag
#ccaacatg  46680
caagcagcgt ccgctgaacc cctattgtcg agcgtattgg cacaaccgga at
#tatttttt  46740
atgtatcata ttatgaggga ggggggcatg cgagatatac gcgtactttt tt
#atcgtgat  46800
ggagatgccg gagggtttat gatgtatgtt atatttccgg ggaaatctgt tc
#acctccat  46860
tacagactaa tcgatcatat acaggccgcg tgtcgggggt ataaaatagt cg
#cacacgtt  46920
tggcagacaa catttttact gtcggtatgt cgcaacccag aacaacaaac ag
#agactgtg  46980
gtgccatcca ttggaacatc ggacgtttac tgtaaaatgt gtgaccttaa ct
#ttgatgga  47040
gaattgcttt tggaatacaa aagactctac gcattatttg atgactttgt tc
#ctcctcgg  47100
tgatttcagc ttcagtgttc attttattat cccagcgcgg ggcgtgtata ca
#aacaaagc  47160
ctgccgcctg caagcggttt agcattttaa cgttaacaac tcgtgtctct gg
#aataaaac  47220
gttttaaaag ccgttctgtg agtttagtgt cgtttccaaa taacgcctta aa
#agttacac  47280
tcgccgtccc aatgagatga gaaaaataat agtcaatgtt taaagacagc cc
#gtgtgatg  47340
ttacgtgaat gggatcttcc gctaagtcag atattattaa cttacgcttt gc
#ttccccac  47400
accgtttacc tgcggtattc tgtaaaggat ctccacgtag caaagctaca ct
#ttttgcat  47460
cagcctccac ttcgtctgtg ggggccacaa taacataagg gatgcgttct cg
#aacgtttg  47520
ggatttgacc ctgtctcatt actaatttat aatatactgt taagtgagcc aa
#gcgacggt  47580
ttatgtaggc ggatggtgga cgactaagct cggccgtcat aacaaactta tt
#aatatcca  47640
atttgggtga tgtaatctgg cgatgtgcat ctgcaattat gcgtccaaac cc
#ggccatcc  47700
cagacggcat ggcccgtcta ttccattcag caatggaaac acacgacgcc tc
#cgccgcag  47760
cacgcgagac ggtgtcgtca tataacaaca gttctacaag tttgcgggca ta
#atcgttaa  47820
taaattgaca gttgtttttt ctaaccaagt cgactccctt cattaaaacc tt
#tccgccgt  47880
aaattacccc aatgtacttt ttctttgtta taagtaaaag ttttataaaa gt
#tttttcac  47940
actccaactt tataggagga caaaacagag ccgttgaaat tatatgtgcc at
#tttctcgc  48000
cgattttagc tatcccctca acaccaacac ccttgaatcg gataaacaca ga
#atccgtat  48060
ctccatatat aacctttacc tcgtacgctt tttgggagag aacgctactt tc
#aatgtctg  48120
gaaacgctgt aataaaacgt tcaaatgcgg cccagttatt atgaatataa tc
#tctggtac  48180
ttaataacat ttgacggcca attgtagtga cagtggccgc tacgtataaa ca
#tggcagaa  48240
atccctgcgc aactccagta aaaccgtaca cggaattaca aactactttt at
#cgcggctt  48300
gttgtttgtc taataacact gcttcatctg aagaacttcc gggtatgcgc gc
#tctaatag  48360
ccttgcgcat agccaaccag tcttttaaaa gaacacccag cagactttct cg
#aacgttag  48420
agcgcacaaa aaaaagacgt tttcctccaa ctgtaaaggt ggcataatcg ga
#tggattca  48480
aacgtttaac cgtctcaaaa tttaacgtta gcgtggtaaa acataagtta tg
#ggcctgaa  48540
ttatacttgg atataaactt gcaaaatcca atacgaccac cggatcgata ta
#aaatcccg  48600
tatcagggtc aaaaaccctg gctcctttat atcctacatt tcgcccactt ga
#cgtaccag  48660
tgggagaaac gctctcgtct tcatccatct cttcctcaac atccccgaca tc
#gggaataa  48720
catccttata ttcaaaagta gctgggtatc ccccatcggg taaaataaat cc
#tcgagacg  48780
aagccagtcc taataaacaa gtgtaaatcc taacctgctg tccgtcgtaa at
#agccttgg  48840
ttaaagtaat tctagctagc cttgcaaccg cggataactc aaggtgtggt aa
#atatttaa  48900
aaaacagttt ccccacaaga gccgagtctt gtatacaata ttcaccaata at
#tcctcgtg  48960
tattcggtcc actagcgtaa tatcccggaa tgtctttgta gggcaaatct ct
#cttggact  49020
catttagagc ttcacgtgca accgaatcta atttataact cgagagtttt aa
#tttttcag  49080
ttgcaattgc atacatatcc agagatatga gaccgttgat ctttaccttg ct
#tcgtcgct  49140
gaaatccgga tttgccaaca tcccatatct taaacagacc cccacggttt at
#actgccat  49200
aaccatcaag cttgagactg tatatagaat taagtttctc cataataaac gc
#ccaatcaa  49260
aattaacaat gttataacct gtggcaaact cgggagcgta ctgttttacg ag
#ggtcataa  49320
atgcaattaa tagctcgaat tcactatcaa actccagcac agtcggctcc gg
#taaccccg  49380
cgtccttcat ttcttgtaca tacctttgtg gtaagtcaca agagccaagg ga
#aaacagta  49440
aaatgtgttc taaagactgt cgagggattg aatataatag acaagaaatt tg
#gattacaa  49500
gatcctccaa atgtgttgca tcgggaaacg ccagctcatt agatcctcct ga
#tttacatt  49560
caatatcgaa acataacaac ttgtagtcag gccatgagtc atcgtttggt at
#agcctgca  49620
gattatccga catgcagtca atttcaacgt cgcttaacgt taattggcga ct
#tgccggtc  49680
gaactcgaac acgttcccca tcaactccag gttttagttg ataccaacca aa
#actaacaa  49740
agccgggatt atccattaga aaacgagtgg tagcgtctac ccgaccttca ta
#ctttttca  49800
actccgggtg aaagttatca caaagataat ttgtaaattt agatgaggga ga
#atacaccc  49860
tgtaaaacgc acatggctgt gtatcgtagt aataaacatc tgtgcgctca at
#aacctcaa  49920
cgcgaaagct ttctggagat gcgcttttaa acgaggtacc atgaaaagcg tt
#cttgtctc  49980
catttaacgt tgcatcattt tgtgttatca tagaactgcg taaacactcg gc
#aagtaata  50040
cagataactc gctacaggaa cgtatgccac aagcggtatc cacctcggct tt
#gtttatat  50100
aaaaatattg acagatgccg tatacatgaa ctgccaccct ttttccacat cg
#ggacatgc  50160
caagtaaagt aataacggta ccaagcggtc gtgttgcagt tgcaaaccgg ga
#tacatctc  50220
cattagacgc ggcttctgtt gtttcgacaa tatcatatac atggaatgtg tt
#aaagcggg  50280
ggtcaaactt atccccacga aagtcgattt ccccccaaat attcacgcgt ct
#aggccagg  50340
ggctggaaca acgaaaatcc agaatcggaa cttcttttcc attacagtaa ac
#tttaggcg  50400
gtcgactaag tgtaccgacg tgaaccccct ttcgttcttc catgggcaca tc
#ttcatcta  50460
aacatttagg ggccaaaaat tgaaacgatg acatggtagt tttgtaacta tg
#aagaaatt  50520
ctctgttact accgcgcccg gttcttgggt tatatttaat ccctgatgct tg
#ggttaaaa  50580
agggattaca aaaccccgtt ctgatcgcca ttttatgtta acgattgata at
#cttgtaaa  50640
aagccagtgt tactgagtaa cacaacccca cgcccttcta atacataaag tg
#taatcacg  50700
tgatttgttg tggtttccgc atatgtaata cccgtttaaa agcctctctt ct
#taatgtat  50760
cgacagactg ggttttgggt ggtcatttga ccctgccaac aaccccccat ta
#ttacgagt  50820
acttcaccaa aatggaaaat actcagaaga ctgtgacagt gcccacgggg cc
#cctgggtt  50880
acgtttatgc gtgccgggtt gaagatttgg atctggagga aatttcattt tt
#ggccgctc  50940
gtagcacgga ctctgatttg gctttattac ctttgatgcg taatttgacc gt
#ggaaaaaa  51000
cttttacatc cagcctggcg gtggtttctg gagcacgcac tacgggtctt gc
#cggagctg  51060
gtattacctt aaaactcact accagtcatt tctatccatc tgtctttgtc tt
#tcacggag  51120
gcaaacacgt tttacccagc tctgcggccc caaatctcac acgcgcgtgt aa
#cgcggctc  51180
gagaacggtt tgggttttca cgctgccaag ggcctcctgt tgacggtgct gt
#tgagacga  51240
ccggcgctga gatatgcacc cgccttggat tagagccaga aaatacaata tt
#atacttgg  51300
tggtcacggc attgtttaag gaagccgtat ttatgtgcaa cgtgtttctg ca
#ttatggag  51360
gactcgatat tgttcatatt aaccatgggg atgttatacg tataccgtta tt
#tccggtac  51420
aacttttcat gcccgatgtt aaccgtctgg tacccgaccc attcaacact ca
#tcacaggt  51480
ctatcggaga gggttttgta tacccaacac ccttttataa caccgggttg tg
#ccatttaa  51540
tacatgactg tgttattgct cccatggccg ttgccttgcg cgtcagaaat gt
#aactgccg  51600
tcgcccgagg agcggcccac cttgcttttg atgaaaatca cgagggggca gt
#actccccc  51660
ctgacattac gtacacgtat tttcagtcct cttcaagtgg aaccactacc gc
#ccgtggag  51720
cgcgtcgaaa cgatgtcaac tccacgtcta agcctagccc atcggggggg tt
#tgaaagac  51780
ggttggcgtc tattatggcc gctgacacag ccttgcacgc agaagttata tt
#caacactg  51840
gaatttacga agaaactcca acagatatca aagaatggcc aatgtttata gg
#catggagg  51900
gcactttgcc aaggctaaac gctctggggt catataccgc tcgtgtggcc gg
#ggtcattg  51960
gtgcgatggt tttcagccca aattctgcgt tgtatctaac tgaggtggag ga
#tagcggga  52020
tgaccgaagc caaggatggg ggaccgggtc catcatttaa tcgattttac ca
#gtttgccg  52080
gacctcattt agctgcgaat ccccaaacag atcgagatgg ccacgttcta tc
#cagtcagt  52140
ctacgggttc atcaaacaca gagtttagcg tggattattt ggcactcatt tg
#tggatttg  52200
gagcacccct gttggcgcga ctgctttttt atctagaacg ctgtgacgct gg
#tgcgttta  52260
cagggggtca cggggatgcg ttaaaatatg ttacggggac ctttgactct ga
#aattccat  52320
gtagtttatg tgaaaaacac acgcggccgg tatgcgctca cacaacagta ca
#ccgactta  52380
gacaacgcat gccgcgattt ggacaagcca cccgtcaacc tattggggtg tt
#tggaacaa  52440
tgaacagcca atatagcgac tgcgatcctc taggaaacta tgctccatat tt
#aatccttc  52500
gaaaacccgg ggatcaaacg gaagcagcaa aggcaaccat gcaggacact ta
#tagggcta  52560
cactagaacg cttgtttatc gatctagaac aagagcgact actggatcgc gg
#tgccccat  52620
gttcttccga gggactatcg tctgtcattg tggatcatcc aacgtttcgt cg
#catattag  52680
acacactgcg tgcgcgtata gaacagacaa caacacaatt tatgaaagtg tt
#ggttgaga  52740
cccgcgatta taagatccgt gaaggattat ccgaagccac ccattcaatg gc
#gttaacgt  52800
ttgatccata ctcaggagca ttttgtccca ttaccaattt tttagttaaa cg
#aacacacc  52860
tagccgtggt acaagactta gcattaagcc agtgtcattg tgtattttac gg
#acagcaag  52920
ttgaggggcg gaactttcgt aaccaattcc aacctgtttt gcggcggcgt tt
#tgttgacc  52980
tgtttaatgg ggggtttata tcaacacgct ctataaccgt aacattatct ga
#aggtcctg  53040
tatccgcccc aaatccgaca ttgggacaag acgcgcccgc ggggcgtacc tt
#tgatgggg  53100
atttagcgcg cgtaagcgtg gaagttattc gggatatacg agttaaaaat ag
#ggtcgttt  53160
tttcaggtaa ctgtacaaat ctctctgagg cagcccgggc aaggcttgta gg
#ccttgcaa  53220
gtgcgtacca acgccaagaa aaaagagtgg atatgttaca cggggcccta gg
#gtttttgc  53280
ttaaacagtt tcacggcctg ttatttcctc ggggtatgcc accaaacagt aa
#atccccca  53340
acccgcagtg gttttggacc ctgttacaac gcaaccagat gccggcagat aa
#acttacac  53400
acgaagagat taccactatt gcagctgtta aacggtttac cgaggaatat gc
#agcactaa  53460
actttattaa tctaccccca acctgcatag gagaattagc ccagttttat at
#ggcaaatc  53520
ttattcttaa atactgcgat cattcacagt accttataaa taccttaact tc
#tataatta  53580
cgggtgccag gcgcccgcgt gacccatcat ccgttttgca ttggattcgt aa
#agatgtca  53640
cgtccgccgc ggacatagaa acccaagcaa aggcgcttct tgaaaaaacg ga
#aaacttac  53700
cggaattatg gactacggct tttacttcaa ctcatttagt ccgcgcggcc at
#gaatcaac  53760
gtcccatggt cgttttagga ataagcatta gtaaatatca cggagcggca gg
#aaacaacc  53820
gcgtctttca ggcagggaat tggagcggtt taaacggggg taaaaatgta tg
#cccgctat  53880
ttacatttga tcgcactcgc cgttttataa taacatgtcc tagaggaggt tt
#tatctgcc  53940
ccgtaacagg tccctcgtcg ggaaatcgag aaaccaccct atccgaccaa gt
#tcgcggta  54000
taattgtcag tggcggggcc atggttcaat tagccatata cgccacggtt gt
#gcgtgcag  54060
tgggcgctcg agcacaacat atggcatttg acgactggtt aagtcttaca ga
#cgatgagt  54120
ttttagccag agacttggag gagttacacg accagattat ccaaaccctg ga
#aacgccct  54180
ggaccgtaga aggcgctcta gaagcagtaa agattctaga tgaaaaaacg ac
#agcgggag  54240
atggggaaac ccccacaaac ctagcattta attttgattc ttgtgaacca ag
#ccatgaca  54300
ccacatctaa cgtattaaac atttcagggt caactgtccc tggtcttaaa cg
#accccccg  54360
aagatgacga actctttgat cttagtggta ttcccataaa acatgggaac at
#tacaatgg  54420
aaatgattta acctccctct ttatccaatt aaagcccaca cgcgggtgag tg
#tacgtaat  54480
aaacaagtca atattacata ttctgttgtg ttttcttttt tgcgtgtagt cc
#ttacccat  54540
atgacctgta atatagtgtg tctccaacca ttcagcttac agtccagtgg ac
#agtaacag  54600
cccgataaca tggaattgga tattaatcga acattgttgg ttctactggg tc
#aagtttat  54660
acgtacatct ttcaggttga actgctacgt cgatgtgatc caagggtggc gt
#gtcgcttt  54720
ttatatcggt tagcggctaa ctgtttgaca gttcgttatt tattaaagct gt
#ttctccgg  54780
ggatttaata cccagctaaa atttggaaac actcccacgg tttgtgcact gc
#attgggca  54840
ttatgttatg taaagggaga aggtgagcgt ttgtttgagt tgctacaaca tt
#ttaaaacg  54900
cgttttgttt atggtgagac taaagactca aactgtatca aagattactt tg
#tctcagcg  54960
tttaacttaa aaacctgcca atatcaccat gagctgtcgt taacaacata cg
#gaggttac  55020
gtatcgagtg aaattcagtt tttacacgac attgagaatt ttttaaaaca gc
#ttaattac  55080
tgctatatta tcacgtcttc tcgtgaggcg ctaaacacat tggaaaccgt ga
#cgcggttt  55140
atgacagata ctataggaag cggtctaata ccacccgtgg agttgtttga tc
#cggcgcat  55200
ccatgtgcta tatgttttga agaattatgt ataacagcta accaaggtga ga
#ccttacat  55260
cgtagattat taggatgtat ctgcgatcac gttactaagc aagttcgggt ta
#acgtggat  55320
gttgacgata ttattcggtg tttaccatat atccctgatg taccggatat ca
#aacgtcaa  55380
tccgccgttg aagcgttacg aacacttcaa accaagacgg tagtcaatcc ca
#tgggagca  55440
aagaacgata cgtttgacca aacatacgaa attgcgagca ccatgcttga tt
#cttataat  55500
gtttttaaac ctgcccctcg gtgtatgtac gccatcagcg agcttaaatt ct
#ggttaacg  55560
tctaattcca ctgaaggacc ccaacgtact ttagacgtgt ttgttgataa tt
#tggatgta  55620
ttaaacgaac atgaaaaaca cgcagaactt acagccgtaa cggttgagtt gg
#cgttattt  55680
ggaaaaactc ccatacactt tgatagggcg ttttctgaag aactcggatc tc
#tggatgca  55740
attgatagta ttttggttgg caatcgctca tcctcaccgg acagtcagat ag
#aagcatta  55800
attaaagcct gttatgccca tcatctatcg tcgcctctca tgcgtcacat tt
#ctaacccg  55860
agtcatgata acgaagccgc cttacgccaa cttttagaaa gagttgggtg tg
#aggatgat  55920
ttaaccaaag aggcgagtga cagcgctaca gcatccgaat gtgatctgaa cg
#atgatagt  55980
agcataactt ttgctgttca tggatgggaa aacctgttat ccaaagcaaa aa
#ttgacgct  56040
gcggaaagaa aacgagtata tcttgaacat ctgtctaagc gctctctaac ca
#gcctcggt  56100
agatgtatcc gcgaacagcg ccaagagcta gaaaaaacac tcagggtaaa cg
#tttatgga  56160
gaggccttat tgcagacatt tgtttcgatg caaaatgggt ttggggcacg aa
#acgtgttt  56220
ttagctaagg tttcccaggc agggtgtatt atcgacaatc gcattcagga ag
#cggccttt  56280
gatgcacata gatttataag gaatacctta gttcgacata cagtagatgc gg
#ctatgtta  56340
cctgcactta cacataaatt ttttgagttg gtcaacggcc cattgtttaa tc
#acgatgaa  56400
caccgttttg cacaaccccc taacaccgcc ttatttttta ccgtggaaaa cg
#ttggccta  56460
tttccgcact taaaagagga attggcaaag tttatgggcg gtgtcgttgg tt
#ccaactgg  56520
cttctcagtc catttagggg cttttattgc ttttctgggg tagaaggcgt ta
#cttttgca  56580
cagagacttg cctggaaata tattagggag cttgtgtttg caaccacact at
#tcacctct  56640
gttttccatt gtggggaggt gcggttatgt cgcgttgacc gtctaggtaa gg
#atccacgc  56700
gggtgcacgt ctcaacctaa aggtataggc agttcccacg gacccttaga cg
#gcatttat  56760
ttaacgtacg aagaaacatg tccccttgtg gctattattc aaagtggaga aa
#cagggatc  56820
gaccagaata ccgtcgtaat ctacgattca gacgtttttt ctcttctata ca
#ccctaatg  56880
cagcggctgg ctccggattc aacggacccg gcgttttcat aacctccgtt ac
#gggggtgt  56940
ggttatgctt tttatgcata ttttctatgt ttgttacggc ggttgtgtcg gt
#ctctccaa  57000
gctcgtttta tgagagttta caagtagagc ccacacaatc agaagatata ac
#ccggtctg  57060
ctcatctggg cgatggtgat gaaatcagag aagctataca caagtcccag ga
#cgccgaaa  57120
caaaacccac gttttacgtc tgcccaccgc caacaggctc cacaatcgta cg
#attagaac  57180
cacctcggac atgtccggat tatcaccttg gtaaaaactt tacagagggt at
#tgctgttg  57240
tttataaaga aaacattgcc gcgtacaagt ttaaggcgac ggtatattac aa
#agatgtta  57300
tcgttagcac ggcgtgggcc ggaagttctt atacgcaaat tactaataga ta
#tgctgata  57360
gggtaccaat tcccgtttca gagatcacgg acaccattga taagtttggc aa
#gtgttctt  57420
ctaaagcaac gtacgtacga aataaccaca aagttgaagc ctttaatgag ga
#taaaaatc  57480
cacaggatat gcctctaatc gcatcaaaat ataattctgt gggatccaaa gc
#atggcata  57540
ctaccaatga cacgtacatg gttgccggaa cccccggaac atataggacg gg
#cacgtcgg  57600
tgaattgcat cattgaggaa gttgaagcca gatcaatatt cccttatgat ag
#ttttggac  57660
tttccacggg agatataata tacatgtccc cgttttttgg cctacgggat gg
#tgcataca  57720
gagaacattc caattatgca atggatcgtt ttcaccagtt tgagggttat ag
#acaaaggg  57780
atcttgacac tagagcatta ctggaacctg cagcgcggaa ctttttagtc ac
#gcctcatt  57840
taacggttgg ttggaactgg aagccaaaac gaacggaagt ttgttcgctt gt
#caagtggc  57900
gtgaggttga agacgtagtt cgcgatgagt atgcacacaa ttttcgcttt ac
#aatgaaaa  57960
cactttctac cacgtttata agtgaaacaa acgagtttaa tcttaaccaa at
#ccatctca  58020
gtcaatgtgt aaaggaggaa gcccgggcta ttattaaccg gatctataca ac
#cagataca  58080
actcatctca tgttagaacc ggggatatcc agacctacct tgccagaggg gg
#gtttgttg  58140
tggtgtttca acccctgctg agcaattccc tcgcccgtct ctatctccaa ga
#attggtcc  58200
gtgaaaacac taatcattca ccacaaaaac acccgactcg aaataccaga tc
#ccgacgaa  58260
gcgtgccagt tgagttgcgt gccaatagaa caataacaac cacctcatcg gt
#ggaatttg  58320
ctatgctcca gtttacatat gaccacattc aagagcatgt taatgaaatg tt
#ggcacgta  58380
tctcctcgtc gtggtgccag ctacaaaatc gcgaacgcgc cctttggagc gg
#actatttc  58440
caattaaccc aagtgcttta gcgagcacca ttttggatca acgtgttaaa gc
#tcgtattc  58500
tcggcgacgt tatctccgtt tctaattgtc cagaactggg atcagataca cg
#crttatac  58560
ttcaaaactc tatgagggta tctggtagta ctacgcgttg ttatagccgt cc
#tttaattt  58620
caatagttag tttaaatggg tccgggacgg tggagggcca gcttggaaca ga
#taacgagt  58680
taattatgtc cagagatctg ttagaaccat gcgtggctaa tcacaagcga ta
#ttttctat  58740
ttgggcatca ctacgtatat tatgaggatt atcgttacgt ccgtgaaatc gc
#agtccatg  58800
atgtgggaat gattagcact tacgtagatt taaacttaac acttcttaaa ga
#tagagagt  58860
ttatgccgct gcaagtatat acaagagacg agctgcggga tacaggatta ct
#agactaca  58920
gtgaaattca acgccgaaat caaatgcatt cgctgcgttt ttatgacata ga
#caaggttg  58980
tgcaatatga tagcggaacg gccattatgc agggcatggc tcagtttttc ca
#gggacttg  59040
ggaccgcggg ccaggccgtt ggacatgtgg ttcttggggc cacgggagcg ct
#gctttcca  59100
ccgtacacgg atttaccacg tttttatcta acccatttgg ggcattggcc gt
#gggattat  59160
tggttttggc gggactggta gcggcctttt ttgcgtaccg gtacgtgctt aa
#acttaaaa  59220
caagcccgat gaaggcatta tatccrctca caaccaaggg gttaaaacag tt
#accggaag  59280
gaatggatcc ctttgccgag aaacccaacg ctactgatac cccaatagaa ga
#aattggcg  59340
actcacaaaa cactgaaccg tcggtaaata gcgggtttga tcccgataaa tt
#tcgagaag  59400
cccaggaaat gattaaatat atgacgttag tatctgcggc tgagcgccaa ga
#atctaaag  59460
cccgcaaaaa aaataagact agcgcccttt taacttcacg tcttaccggc ct
#tgctttac  59520
gaaatcgccg aggatactcc cgtgttcgca ccgagaatgt aacgggggtg ta
#aatagcca  59580
gggggtttgt tttaatttat taataaaaat gtgtattacg ttactcatgt gt
#ctccatta  59640
cgcatcacag ggggtattta tacccgataa tatacaaaac gcgttttgta cc
#tctaccgc  59700
acccgatatc ttaacggggg ttattatgga atcgtctaac attaacgcgc ta
#caacaacc  59760
gtcgtctatc gcacatcatc cgtccaaaca gtgcgcttca agtctcaatg aa
#acagtaaa  59820
agattctccc cccgcgattt atgaagatag gttagaacac acgccggtac aa
#ttaccccg  59880
cgacggtaca ccccgagacg tatgttctgt gggacagcta acctgtcgag ca
#tgtgcaac  59940
gaaacctttt cgccttaacc gcgacagcca atacgactac ttaaacacat gt
#ccaggggg  60000
ccgtcatatt tcactggcac tggagattat aacgggtcga tgggtttgca tc
#ccgcgtgt  60060
gtttccggat accccagagg aaaaatggat ggcgccatat attattccag ac
#cgagaaca  60120
accatcatca ggggatgaag attctgacac cgattaaatt taacttaaat aa
#aaccttac  60180
cacccataaa aacgccttct gtttgtttaa cacgacaccg cttaacaaaa aa
#aaacccaa  60240
acacgccttt tatgaatgta atacttttat ttgttggtta acaccgcccc ac
#catcatct  60300
gatttgcaaa catatcggcg tcgtctgccg tggacccctg tattaaaggg gc
#cttggaac  60360
tagcctccac tgcatttaca tcttgtccaa ctgtatctgt atgtggggtg ct
#tgttgtat  60420
tttgggatga gcatagaccc gaaacgcttt gaagctgttt taataaaatc ga
#tattcgag  60480
gatcccgtgt cccctctggt atatttgtat ggtgcgacaa aggcatttgt gt
#cccatttt  60540
gtgattttag ctctgtaacc tcctgttgca gttttgccac aaccccagca ag
#ctcttcgt  60600
gctgaccatt agaaactctg tgtctcctct gccaatatga tggagaaact cg
#acgtctcc  60660
gatgcgttat atacgttggt tcaccgggaa aatatatatt tgagggaaac tc
#tccgtcca  60720
tttgagactc cccactagaa aaagaatcca attccctttg atccatgctc tt
#gaaatccc  60780
gttttcctgg acgacggaca tcggttttgt ctggaaaatt tacacacggg gt
#ctgcaagt  60840
caataccccg ttcggcggcc aatgcgttca taaatgcgga catttgcatt tc
#caaacgat  60900
tgggtggtgg atatcccgga aacccgtacg gtcccccgaa gtgtcccgga gg
#gcaaccat  60960
aaccccctgt attaaatggg aaggcaggcg ggtgtggaga tccatatggc cc
#gacgatat  61020
actgtccgtt atttggagct ccaattgata cctgcggatt tttagtctgc cc
#ggttaaca  61080
gctgtgaata atacgcggta ggtatcagta caaattcccc tccggttgga ac
#gcccgacg  61140
ggggctgtgg tgagatacca ctagcgttac ctgctacaga agccatatcg ct
#gtcgttcc  61200
tacacaactg cgtaaccttt aaatgcggaa cagtcttttc acaatcttca tt
#tgattccc  61260
caacacccaa cgcgagatcg tatatgggcc cgccggggtg gaatgtggcg tt
#tataacac  61320
ccgcgttggg taatttagac tccaccccat taacgttggt tatccgagca ag
#tccatatc  61380
cggtgctagc ctgaagataa acgtgaccca taattccggc ttcgcgtcta cg
#ttttgcaa  61440
ccacgtccca tctatctctt aaaagcatat tgttcacggc tgtggataat aa
#caccttgg  61500
cgagtttatc ttcgctaacc ttccatactt tatttaaacc cgcgtagtct tt
#aaccagcg  61560
acaataaccg cgctttactt tccatcgata aaacccggaa tggttcaatt ga
#agattccg  61620
gggtacagtc ataattgacc actgttccaa cgcgtcttcc aacaacacat aa
#cgcaacat  61680
gggtaaaaaa attaccgtct ggtatctcat tcggggacaa tcgttttgaa ga
#cagggata  61740
cggagggtaa gtaatttgtg accaagtata acgcacgttc tagcggagat aa
#tacagaat  61800
ctctatttcc aaaaaaattc gaatgggccg cttcaaacag caccgcatgt ag
#ttgagggc  61860
atctaacgat acccaaaaaa aaaggtccgc gtatgtcctc aatgattgcg at
#tacttcac  61920
ccacgacaca gtcttttcga tgatcgatgt ttattggtat tttactagta gg
#cggcaaag  61980
cggaccgcac aatctctggg gtaatattta attccccttc gtcctttgaa ta
#taaggcta  62040
aatacccagc cacgtataac gcttcacagt tctcttcgtc agcttcagca gc
#cattataa  62100
acaccccacg gaccggatag tgaatactca cggtgtggag gcaaactgag ga
#atgacacc  62160
caaacagaca aaatatagaa gatcatagtc actgttaacg ttgaactgcg ca
#aggcggcg  62220
actttcttcc aatgccgccc ttacacgcgg ttggtgcatt aacattccaa gt
#ccccgttc  62280
atattgcaac ataacactgt catgtattga taccacggcg gctatgggta gg
#gatgtaac  62340
attttgtcgg cggtgttcta attccaatgc aattaagctt atgagccgat ct
#tggtactg  62400
tccagaagaa atatctatta cggttcttcc taaacttcca cgactaagct gg
#gtatgcgc  62460
gtctaaacaa agagcaacta atccaggaaa catttcagtc agctctgtgg tc
#cgatttaa  62520
cgtatacagt ggtgctatat atcgttcaca taaaaattga aagttattat ta
#ccgctttt  62580
aaacttccca tcaaaccccg tcgctccgcg caagattaca ttgttggtag gg
#gttcctgt  62640
tgcttctgac acaatcaaac ccagttgaaa attatttttt agtttatctc cg
#tatacgtt  62700
cccgttccat aataagcgcc ttaataataa taacgccgta atcgtgtcaa tt
#gttaacct  62760
taatagagtt tggtcttcca taagaaacac gttttgggcc cgttctaaat ac
#gccgcggc  62820
cgcctgttga atcttgtcca catatgcggt atgattgcga tcaataatgt ca
#ttaacccc  62880
aggattaaac tgtccaggtg caggcggtag gacctgcaac cgtataagcg ca
#tccataac  62940
agaatgtgac gttaaggcgc cttgatcata ccgcccccca cgagcatgaa ac
#tggtcgcg  63000
tggtagacga tcatagcaaa attgataact gtttttattt tcgtgtgttg tc
#atataatt  63060
cacaaatgtc tcagtatatt ccggtaggtg ctctataagg ttcccgaagg ac
#gaaacttg  63120
aggttcgtgg acactattag atgtcctata cattaaatat aaacataata cc
#gcacactc  63180
gaacgcggag tacgctctat ctccaacata cattctcccg gcggactgta ga
#catgttac  63240
cgttgtgttc ataaacgtac gggaaatgcg cccgtcttta caatcaactc cg
#cgtgcagc  63300
tacgggccta tctaacacaa gccgttcctg cagagtacga taccatggcc cg
#aaaacaat  63360
ccctggagag ttattgcccc ttgcccttcc caagtacacc agggtgataa aa
#tccacttg  63420
aaagtttgta tcgtactgca acggtgcatc atttttggca atctgtacct cg
#gggtgtat  63480
agactcattg cgtattattt ctgtacgtgt acattcctca gattgtgcat ct
#gcttcttc  63540
cgcctcggca gcagccgtct ccagggaatc caaaaccttg gccatgcgcg tt
#agttgttc  63600
ttcgaggggc tttaaacgac gatctatttc cgttggtaac gtaatcgttt cc
#ccgcgaag  63660
gttgtctaat gcggcaacgg ccgccgcatt ttttaacgtt aacgtatttt tt
#tccaaatc  63720
gggattcata cgccctctta actcaaacgc gggagccgtc cagtagtgta tg
#gggaagtt  63780
gggggctata aagttcttag tggtagacaa aaatatccca catttattcg ga
#aacgagat  63840
agatccgaac ccatatctcg ccgtcatggt gtctgcagca aacaaagtca ac
#tggcgtga  63900
atataaaccg gtactgcttt aaaagctgtt ttcttaccca tgggaaaaca tc
#ccggttat  63960
actttgtaaa attccaccac aagcacctaa agaaggcctt ctaaggggta aa
#tccacccc  64020
acargctgca ttttcttcaa actttgttaa agcggaacga tggcatgatt tc
#gcacgctt  64080
tttcgcaaga gagcatacgt gaattttctt tttgcataga cgtcttcgct ct
#ctaacgga  64140
ccttatcggg ggggtatatt ccgctacatt ctccaaatgc gacgctagca ta
#acaaggtt  64200
tccatgaatc accttcgggg gtaaccgagt tacctgtaac aggttcagac cc
#cgttgaga  64260
tacaaacaca aggagggggg tcaccattat ttcatcagat cccgtgggtg tg
#gtttcctt  64320
tattaaagcc acggtatccc tcagctggcg cataccctcg caaaactggt ga
#tacttagt  64380
aggggtatgt atattagcgc taaaacggca agattttaat tccactataa aa
#caaacggt  64440
ctttccggca ccactggatt ccgtttgtat aatacaaaca caatcggggc gt
#cggcgtcc  64500
caaatttact tcaaacgaca ttgatatgcg tacagccctt tgaacatcca cg
#tgggataa  64560
cggcgacagg agttttgcca gcctcgggtt gaacgcgtcc gcgaaacctc ga
#cgtacgtt  64620
atcaatatcc tttttgagta catcgtaaaa acgagtgtgg caacgttgtc cc
#aaacgaaa  64680
acacttggcc cgaattcgac tagcggacat atttgaagtt ccgtcccaga ag
#ataaccta  64740
agacgcgttt gtctacaata aacatgtcaa cggataaaac cgatgtaaaa at
#gggcgttt  64800
tgcgtattta tttggacggg gcgtatggaa ttggaaaaac aaccgccgcc ga
#agaatttt  64860
tacaccactt tgcaataaca ccaaaccgga tcttactcat tggggagccc ct
#gtcgtatt  64920
ggcgtaacct tgcaggggag gacgctattt gcggaattta cggaacacaa ac
#tcgccgtc  64980
ttaatggaga cgtttcgcct gaagacgcac aacgcctcac ggctcatttt ca
#gagcctgt  65040
tctgttctcc gcatgcaatt atgcatgcga aaatctcggc attgatggac ac
#aagtacat  65100
cggatctcgt acaagtaaat aaggagccgt ataaaattat gttatccgac cg
#acacccaa  65160
tcgcctcaac tatatgtttt cccttgtcca gatacttagt gggagatatg tc
#cccagcgg  65220
cgcttcctgg gttattgttt acgcttcccg ctgaaccccc cgggaccaac tt
#ggtagttt  65280
gtaccgtttc actccccagt catttatcca gagtaagcaa acgggccaga cc
#gggagaaa  65340
cggttaatct gccgtttgtt atggttctga gaaatgtata tataatgctt at
#taatacaa  65400
ttatatttct taaaactaac aactggcacg cgggctggaa cacactgtca tt
#ttgtaatg  65460
atgtatttaa acagaaatta caaaaatccg agtgtataaa actacgcgaa gt
#acctggga  65520
ttgaagacac gttattcgcc gtgcttaaac ttccggagct ttgcggagag tt
#tggaaata  65580
ttctgccgtt atgggcatgg ggaatggaga ccctttcaaa ctgcttacga ag
#catgtctc  65640
cgttcgtatt atcgttagaa cagacacccc agcatgcggc acaagaacta aa
#aactctgc  65700
taccccagat gaccccggca aacatgtcct ccggtgcatg gaatatattg aa
#agagcttg  65760
ttaatgccgt tcaggacaac acttcctaaa tatacctagt atttacgtat gt
#accagtaa  65820
aaagatgata cacattgtca tactcgcgtg tacgtgtttt tcttttttat at
#atgcgtca  65880
tttattacca catcctttaa tcccgccttt atctccctaa aacggagtgg ta
#atattaaa  65940
agccgccaag cctgttggtg ggtgaggagg ggtaaaggca cgctgtgtgc at
#aacgttgc  66000
ggtgatattg tagcgcaagt aacagcgact atgtttgcgc tagttttagc gg
#tggtaatt  66060
cttcctcttt ggaccacggc taataaatct tacgtaacac caacccctgc ga
#ctcgctct  66120
atcggacata tgtctgctct tctacgagaa tattccgacc gtaatatgtc tc
#tgaaatta  66180
gaagcctttt atcctactgg tttcgatgaa gaactcatta aatcacttca ct
#ggggaaat  66240
gatagaaaac acgttttctt ggttattgtt aaggttaacc ctacaacaca cg
#aaggagac  66300
gtcgggctgg ttatatttcc aaaatacttg ttatcgccat accatttcaa ag
#cagaacat  66360
cgagcaccgt ttcctgctgg acgttttgga tttcttagtc accctgtgac ac
#ccgacgtg  66420
agcttctttg acagttcgtt tgcgccgtat ttaactacgc aacatcttgt tg
#cgtttact  66480
acgttcccac caaaccccct tgtatggcat ttggaaagag ctgagaccgc ag
#caactgca  66540
gaaaggccgt ttggggtaag tcttttaccc gctcgcccaa cagtccccaa ga
#atactatt  66600
cttgaacata aagcgcattt tgctacatgg gatgcccttg cccgacatac tt
#ttttttct  66660
gccgaagcaa ttatcaccaa ctcaacgttg agaatacacg ttcccctttt tg
#ggtcggta  66720
tggccaattc gatactgggc caccggttcg gtgcttctca caagcgactc gg
#gtcgtgtg  66780
gaagtaaata ttggtgtagg atttatgagc tcgctcattt ctttatcctc tg
#gactaccg  66840
atagaattaa ttgttgtacc acatacagta aaactgaacg cggttacaag cg
#acaccaca  66900
tggttccagc taaatccacc gggtccggat ccggggccat cttatcgagt tt
#atttactt  66960
ggacgtgggt tggatatgaa tttttcaaag catgctacgg tcgatatatg cg
#catatccc  67020
gaagagagtt tggattaccg ctatcattta tccatggccc acacggaggc tc
#tgcggatg  67080
acaacgaagg cggatcaaca tgacataaac gaggaaagct attaccatat cg
#ccgcaaga  67140
atagccacat caatttttgc gttgtcggaa atgggccgta ccacagaata tt
#ttctgtta  67200
gatgagatcg tagatgttca gtatcaatta aaattcctta attacatttt aa
#tgcggata  67260
ggagcaggag ctcatcccaa cactatatcc ggaacctcgg atctgatctt tg
#ccgatcca  67320
tcgcagcttc atgacgaact ttcacttctt tttggtcagg taaaacccgc aa
#atgtcgat  67380
tattttattt catatgatga agcccgtgat caactaaaga ccgcatacgc gc
#tttcccgt  67440
ggtcaagacc atgtgaatgc actttctctc gccaggcgtg ttataatgag ca
#tatacaag  67500
gggctgcttg tgaagcaaaa tttaaatgct acagagaggc aggctttatt tt
#ttgcctca  67560
atgattttat taaatttccg cgaaggacta gaaaattcat ctcgggtatt ag
#acggtcgc  67620
acaactttgc ttttaatgac atccatgtgt acggcagctc acgccacgca ag
#cagcactt  67680
aacatacaag aaggcctggc atacttaaat ccttcaaaac acatgtttac aa
#taccaaac  67740
gtatacagtc cttgtatggg ttcccttcgt acagacctca cggaagagat tc
#atgttatg  67800
aatctcctgt cggcaatacc aacacgccca ggacttaacg aggtattgca ta
#cccaacta  67860
gacgaatctg aaatattcga cgcggcattt aaaaccatga tgatttttac ca
#catggact  67920
gccaaagatt tgcatatact ccacacccat gtaccagaag tatttacgtg tc
#aagatgca  67980
gccgcgcgta acggagaata tgtgctcatt cttccagctg tccagggaca ca
#gttatgtg  68040
attacacgaa acaaacctca aaggggtttg gtatattccc tggcagatgt gg
#atgtatat  68100
aaccccatat ccgttgttta tttaagcaag gatacttgcg tgtctgaaca tg
#gtgtcata  68160
gagacggtcg cactgcccca tccggacaat ttaaaagaat gtttgtattg cg
#gaagtgtt  68220
tttcttaggt atctaaccac gggggcgatt atggatataa ttattattga ca
#gcaaagat  68280
acagaacgac aactagccgc tatgggaaac tccacaattc cacccttcaa tc
#cagacatg  68340
cacggggatg actctaaggc tgtgttgttg tttccaaacg gaactgtggt aa
#cgcttcta  68400
ggattcgaac gacgacaagc catacgaatg tcgggacaat accttggggc ct
#ctttagga  68460
ggggcgtttc tggcggtagt ggggtttggt attatcggat ggatgttatg tg
#gaaattcc  68520
cgccttcgag aatataataa aatacctctg acataaaaaa catgtataat aa
#aaagtcac  68580
tataaacgta ttctctacaa tactttattc gcgaataata cacactacct tt
#gggttttt  68640
ttcccgtccc caaatggtgt ttggtgcact ctaccaaaaa atagagcgcc ta
#aatatgct  68700
atataacgcc tcccagcaaa atacggttca aaggcattac ccgatattgt at
#tgtagtac  68760
agggcaatgg gaattgatga tcccaataaa cggcatagac gcacagcgcc gt
#tatagcag  68820
gggtctccag agtacagggt atctaagtac cgggatatct catactcatg cc
#tttccgtg  68880
acagaaacat caaccggaac agtatccgat aaaccaactc ctgtttttgc aa
#ggcgtaaa  68940
attcgcacac cttccttttt tgcaagatgt gacgtttcct tgtaacaggg aa
#gctggggg  69000
agtggtaaga acaacaaagt ttcagccaac gtgccaataa agcccacttc cc
#tcaagagg  69060
ctgtttgctg tatccacaat ggtccgtatt aaatcttgag caacttgatc cg
#tgtcatca  69120
tcactgggta acgcgttaac ataactacgc gttaaatctt caataacggc at
#aacaatta  69180
aacgcttccc accgagacag tatatattga acaatcacga accgttgaca gg
#acgtcaga  69240
tcacgtccgt aagcatgccc gaaaaatgga agttcccccc gttcgccata ta
#ccgcaaca  69300
actgcggtat atatcgtctc acgggcttca ttaagttcat cttcaagtcc ag
#gccatttt  69360
ctggctttaa atataacctc gtccgcaaaa aaaaccgcac atgataacgc gc
#ggatacaa  69420
tgagtagtgg ctttatggcg aggatcccaa atgtccatta cccgggggat gg
#tcctaatc  69480
tgtacaaagt tacttagtgt aatatgatcg gacttcttac gccgtctagg ct
#gtttctca  69540
gaatacggtt cacccgaaat cggcacatca tctgctttta cgtcttccgt aa
#ccacatca  69600
gcagcgcgcc gactaacaat tatacttgtt ttttcatcgt cgttacttcc gt
#taagcgcg  69660
tctcgtatct cgggcgtccc gtcgaataat ccactcacta gctcctgcaa ac
#cttctggt  69720
aactccaaca tacgcatata caccaatgaa aaactggctt cgtttggtac gt
#acataaag  69780
ccatttgtgg tattaatggc ggtgggtgtt ggaaacaatt ttagcttatt ct
#cgcgcgta  69840
acatctaccc ccgccaccaa tgttaaatgc gtcacgggga gggacacgag at
#aatctgcg  69900
agcgtagggt cctccacttc aacatcaaat gttccgcaaa ggtcgcgatc ca
#ccgccccc  69960
gatcccgctg caagtaaggc cactcgatcc aaaaacacgc agttattatt gg
#atgatacc  70020
gcccatgtct tcccggtgcg attgagctca cttcgaacgt aactggcaac ag
#atctgtca  70080
ccgggtccga ccccgcgaac aacatgtcca aattttgcga tctcgcctcc at
#gtttgcgg  70140
ggtatggaaa ttaagcatcc cccgcatata aaatacgccc tggtagcacg ct
#cgttaaaa  70200
taaaacgtta cgccgttata agatacggtt gaatgatatg gaaattccat at
#taaagcgt  70260
ttatcggaac attaacctcg aacttgccgt cccgtgatcg tgtgatcgcc aa
#ccttaggt  70320
ccacaccgaa tatgagaaat atataactac acgcaaacat tcaaaacacc gt
#ggtatcat  70380
taacgtcata tgaaaagatc caatcaatcc aatcaaccac acctcctacc gt
#ttagcacg  70440
tcagctatgt gacatgctcc aaacatacgt aaacatttag agagggtgtt at
#aacagtct  70500
gtcaggcggg gtatattcta cataatacaa ggatcggctt taactttgtc aa
#cattttta  70560
ctttggacta taaactgcga ctgaacgtta tgaacccacc ccaagcccgc gt
#ctcggaac  70620
agacaaagga cttgcttagc gttatggtta accagcaccc cgaagaggac gc
#aaaagtgt  70680
gtaaatccag tgataattca ccgctttata acaccatggt tatgttatcg ta
#tgggggtg  70740
atacggactt actattaagc tctgcatgta cccgcacatc taccgtaaac ag
#gtcggcgt  70800
ttacgcaaca ctccgtgttt tatattatat ccacggtgtt gattcaacca at
#atgttgta  70860
tcttcttttt tttttactat aaagcgacac gctgtatgct cttattcaca gc
#cgggttac  70920
ttctgacgat tctacatcac tttcgactta ttattatgtt attgtgtgtc ta
#cagaaata  70980
tacgatcaga cctgctaccc ttatctacat cccagcaact gctgcttgga at
#tattgttg  71040
tgactcgaac aatgctattt tgtattacgg cgtattatac tctttttata ga
#cacccggg  71100
tgttcttttt gattaccgga cacttgcaaa gtgaggttat ttttccagat ag
#cgtttcaa  71160
aaatacttcc tgtgtcgtgg ggtccaagtc cagccgtgtt actggtaayg gc
#ggcagtta  71220
tttacgctat ggactgtttg gtggacacgg tatcctttat tgggccaagg gt
#gtgggtcc  71280
gtgttatgtt aaaaacatct atttcgtttt agtccatttc aataaatgta ct
#ataattgt  71340
tcagtctaaa aataatgttg ggtatttata attaccgccc ccgtgttact tg
#gaaacacc  71400
catacatatg ttccactcta catcaaactt ctcgcagttt tcttgttccc gc
#acacgttt  71460
acacgtccgg attcaagtcg caacgctgct gacaaaatga caacggtttc at
#gtcccgct  71520
aacgtgatta ctacaacgga atctgatcgt attgctgggt tatttaacat cc
#cagcgggg  71580
atcattccaa ctggaaatgt gctgtcaacc atagaggtgt gtgcacaccg tt
#gcattttt  71640
gattttttta aacaaatacg atcagatgat aacagccttt actcggctca at
#tcgatatt  71700
cttttgggga catactgcaa tacattaaac tttgtgcgtt ttctagaact tg
#gactgtct  71760
gtcgcttgca tctgtactaa atttccggag ctggcttacg tgcgagatgg cg
#ttattcaa  71820
tttgaggtac aacaacccat gatagcacgt gatggcccac atcccgtcga tc
#agcctgtt  71880
cataattata tggttaagcg gatacacaag cgttcgttaa gcgctgcgtt tg
#caattgca  71940
tcggaagcgt tgagtttgtt aagtaacaca tatgtcgatg ggacagagat tg
#actcatcg  72000
ttacgtataa gagctatcca acagatggct cgtaatttac gcaccgtttt gg
#actcattt  72060
gaacgaggca ctgccgatca acttcttggt gttctattgg agaaagcccc ac
#cgctatcg  72120
ctgctttcac caattaataa attccaaccc gagggacatc taaatcgtgt tg
#cacgcgcg  72180
gccctacttt cggacctcaa acgtagagtc tgtgcggata tgttttttat ga
#cccgacac  72240
gccagggaac ctaggctgat ctctgcgtat ctgtcggata tggtttcgtg ca
#cccaacca  72300
tcggtgatgg tatcacgaat aactcataca aacactcgcg gacggcaggt tg
#acggtgtg  72360
ttggtaacaa cagcaacctt aaaacggcaa ctattacagg gaattttaca aa
#ttgacgac  72420
accgccgctg acgtaccagt aacatatggc gaaatggttc tacaggggac aa
#acttggta  72480
accgcccttg tgatgggaaa ggccgtccgc ggaatggatg atgtagcccg cc
#atctcctt  72540
gatataaccg accctaacac gttaaacata ccgtctatac ccccacaatc ca
#actccgat  72600
tcaacgacag ctgggcttcc ggttaacgcc cgtgttcctg cggatttagt ga
#ttgttggg  72660
gataaacttg tattcttaga agcattagaa cggcgggtct accaagctac gc
#gcgttgcc  72720
taccctctta ttggaaatat agatattacg tttatcatgc caatgggagt gt
#ttcaggca  72780
aactccatgg acagatatac acgacacgcc ggcgattttt caactgtatc cg
#aacaggat  72840
ccacgtcaat ttccacccca agggattttt ttttataata aagatgggat at
#taacacag  72900
ttgactcttc gtgatgcaat gggtaccatc tgccacagtt cattgcttga tg
#ttgaggcc  72960
acacttgttg ccctccgcca acaacattta gatcgtcagt gttattttgg tg
#tatacgtg  73020
gccgagggta cagaggacac attggatgtt caaatgggga ggtttatgga aa
#cgtgggca  73080
gatatgatgc ctcatcaccc tcattgggta aacgaacatt taacaattct ac
#agtttata  73140
gctccgagca acccgcgtct aaggtttgaa ttaaaccccg cctttgattt tt
#ttgttgca  73200
ccgggggacg tagaccttcc cggaccgcag cgtcccccgg aagccatgcc aa
#ccgttaac  73260
gcaacattac ggattatcaa cggaaacatt cccgtgcctc tatgtcccat tt
#catttcga  73320
gactgtcgcg gaacccaact cggtttggga agacatacaa tgaccccggc aa
#ccattaaa  73380
gccgtaaagg atacatttga agaccgcgca tacccaacta ttttctacat gc
#tagaggct  73440
gttattcatg gaaacgaaag aaacttctgt gcgttactgc gactgttaac ac
#agtgtatt  73500
cgcgggtatt gggagcaatc ccacagggtg gcatttgtaa ataactttca ca
#tgttaatg  73560
tacataacta catatctcgg aaacggtgag cttcccgaag tctgtattaa ta
#tatatcgg  73620
gatttactgc agcatgtaag agcattacgc caaactataa ccgattttac aa
#tacaagga  73680
gagggccata acggcgagac ctcggaagcg ctaaataaca tccttacgga tg
#acacgttt  73740
attgcaccta ttctatggga ttgtgatgcg ttaatatacc gtgatgaagc cg
#cccgagac  73800
cgactccccg caattcgtgt aagcgggcga aacggatacc aagcccttca ct
#ttgtggat  73860
atggccgggc ataacttcca acgacgcgat aatgtgttaa tccacgggag ac
#ccgttcgg  73920
ggagacacgg gtcagggtat tcccattacc ccacaccatg accgtgaatg gg
#gtattctc  73980
tccaagattt actactatat tgtcattcct gcattttccc gcggttcctg tt
#gtacaatg  74040
ggcgtgcgtt atgatcgcct ataccctgcg ttacaggcag ttatcgttcc gg
#aaattccc  74100
gctgatgaag aagccccaac taccccagaa gatccaagac accctcttca cg
#cacaccaa  74160
ctcgttccga actctcttaa cgtttacttc cataatgcac acctaaccgt tg
#atggtgat  74220
gcattgctca cactacaaga gttaatggga gatatggctg aacgaacgac gg
#ccatttta  74280
gtatcaagcg cccccgatgc gggagccgcc acggcaacaa ccagaaatat ga
#gaatatat  74340
gacggagcgc tttaccatgg ccttattatg atggcatatc aggcgtacga tg
#aaaccatt  74400
gcaacgggta ctttttttta tcccgttccg gtcaaccctc tgtttgcatg tc
#cggaacat  74460
ttggcatcat tgcgtggaat gacaaatgct aggcgggttt tggcaaaaat gg
#taccacca  74520
atccctcctt ttctgggagc caaccaccac gcaactatac gccaacccgt tg
#cctaccat  74580
gtaacgcata gtaagtcgga ttttaatact cttacatatt ctcttcttgg ag
#ggtatttt  74640
aagtttacac caatatctct tacacatcaa ctacgaacgg gatttcaccc cg
#ggattgcc  74700
tttaccgtag tgcgccagga tcgctttgcc acagagcaac ttttatatgc cg
#agcgtgct  74760
tctgaatcgt actttgtcgg acaaatccaa gtacaccatc atgatgctat tg
#ggggggta  74820
aactttaccc taacccaacc cagagctcac gtggacctgg gagtcgggta ta
#cagctgta  74880
tgtgccacag cagccctgcg atgccctctc acggatatgg gcaatactgc cc
#aaaatctt  74940
tttttttcac gaggaggagt gccaatgtta catgataacg ttaccgaatc gt
#tgcgtcgt  75000
ataacagcat cggggggtcg cttaaatccc accgaacccc tacccatctt cg
#gcggacta  75060
cgtcctgcta catcggcagg aattgcacga gggcaagcct ctgtgtgtga gt
#ttgtggcc  75120
atgccggtgt ccactgacct acaatatttt agaactgcat gcaatcctag ag
#gtcgagca  75180
tctggaatgt tatatatggg tgaccgtgac gccgacatag aggctataat gt
#ttgatcac  75240
acacaatcgg atgttgctta tacagatcga gcaactctta acccatgggc at
#cacaaaaa  75300
cattcatacg gtgacaggct atacaacgga acatacaacc ttacaggcgc tt
#ctcctatc  75360
tacagcccat gctttaagtt ttttacacca gcggaggtta acactaattg ta
#atacactg  75420
gatcggcttc taatggaggc aaaggctgtg gcgtcgcaaa gctccaccga ca
#ctgaatat  75480
caatttaaac gccctcccgg ttctaccgaa atgacacagg atccgtgtgg cc
#tttttcaa  75540
gaagcatatc caccactatg ctcaagcgat gcggccatgt tacgaacggc tc
#acgcggga  75600
gaaaccgggg cagatgaagt tcacttagcc caatatctga ttcgagacgc gt
#cgcccctt  75660
aggggatgtc ttcctcttcc gcgataattt caccacgccc acatacccac tc
#ccaataaa  75720
agccctgtag agcgcattgg catcttactt gagatttgga tacgctcggc cg
#acttggtc  75780
tgtttcacgc ttccttaaac aacatggcta tgccatttga gatagaggta tt
#gttaccag  75840
gagaactatc cccggcggaa acatctgcat tacagaaatg tgagggaaaa at
#tattacct  75900
tctcaaccct gcgtcatcga gcttcactgg tggatatagc gctgtcgtca ta
#ttacatta  75960
acggtgctcc accagacacg ctctcgctgt tagaggcata ccgaatgcga tt
#cgcggcag  76020
ttataacacg ggtcatcccg ggaaagttgt tggcgcatgc cattggcgtg gg
#tactccta  76080
cacccgggtt gtttattcaa aatacatccc ccgttgatct ttgtaatggc ga
#ttacatct  76140
gcttacttcc tccggttttc gggtccgcag actcaattcg cttggactct gt
#aggactgg  76200
aaattgtttt ccctttaacc atcccccaga ccttaatgcg agaaatcatc gc
#caaagtgg  76260
ttgcacgggc cgttgagcgc acggccgcgg gtgctcaaat tttaccccac ga
#agttctac  76320
gaggcgcgga tgtcatttgt tacaatggaa ggcgttatga actcgaaaca aa
#tttacaac  76380
atcgggacgg atcggatgcg gctattcgca cattggtttt aaatctaatg tt
#ttccataa  76440
acgagggatg tctgctttta ttggcgctga ttccaacttt gttagttcaa gg
#agcacacg  76500
acggttatgt aaatttattg atacaaacgg ccaattgcgt tagagaaacc gg
#ccagttaa  76560
ttaatatacc gccaatgccg cggattcaag acggccatcg ccgatttccc at
#atatgaaa  76620
ctatttcatc ttggatatca acatcatcta gactggggga taccttggga ac
#tcgcgcaa  76680
ttttacgcgt ctgtgtgttt gatggaccct ctactgttca tccgggagac cg
#cacggccg  76740
tgattcaagt gtaaacaggt gttaataaaa acacaaccag tctagttaca tt
#tcacgcgt  76800
cttgttttta tttaataggc ataaacacgg aatccggtat acatgaactg cc
#aatataca  76860
cggacataat taatgcaacc atcagatcat ctgacattgt tcccgtggta cc
#tttacccg  76920
tgtaagtttt tgtgtctaga ttacccatac cgcctttaat tacctctgtc ag
#gttatcca  76980
actgtttaca tagatactcc acggggtcta cacctaactt tactgttagg ga
#tacaagct  77040
cctgtgaggc tattatattt ccggagttaa atcgtttaac aaaatagtct ac
#ggccggcg  77100
ttttttgttt ttgtaataaa aaaaaagggt acgccacgct acatccggga gg
#tatggaat  77160
gataaaacag taacactgga gcggaagata gcacgtttcc cttttcgagg ac
#agcaaact  77220
gttgtgctat agccaacgat atggcaactg cagaatcctg gctgctgttt cc
#ctctatag  77280
aaacgtgtac gtttgtaaat gtattggggt gtaaagcgag tatgtggcct aa
#gcattgag  77340
taacgcaacg ccctatctca ctggaagacg tgccagttaa agctctaaga aa
#aaagtgct  77400
ccaatccaaa tataatccaa tccgacttat aacgaccaac aatcgctaca cc
#agtaccag  77460
acgctcgtgt atttgaggta aatgcagggt ctacgtaaac gtacaacact ga
#cgataata  77520
tagcacaatt cgcaacggtt gacggccgat ataaaataaa cctctcacgg gc
#agtttttg  77580
taaataatgg ccggtcaaac cccacacccc cagaattctg tttacgccca cc
#tacaattt  77640
cctgcacgaa ggagtcggcc ataaataaat ctgcagtgcg ccgcatggct cc
#atccattg  77700
tgatgaaaac cggcttattt aatacataac acgaacaagc tgtgacatcg ct
#atgtgcta  77760
aaacacgcgg catgtgatcg tcgcatacat atgtaacaac gtttaacaac tg
#atccgacg  77820
atccacgtaa gttatacaaa aaacttgtac ttgcttttcc ggtatttgtt ga
#tgaaacaa  77880
aaataatttt acaattggtt tgatttaaaa atccgactat agtttgtaca gc
#atcaggtc  77940
gaataaaatt agcttcatcc acaaacagaa gattaaaatc ttgacctcgg at
#accctgga  78000
acgatagaaa gatatatagt taccccacca aagtttaaat gtatccttaa at
#accacgta  78060
cgtaaaaaat gtttgaatac gtacatattt cttttttttt ccagtacaac ca
#tatccggt  78120
gtataatgga agcccatttg gcaaatgaaa ccaaacatgc actttggcat aa
#tgatcaca  78180
caaaaggatt actacacgtt gtgataccta acgcggggct tattgcggcc gg
#aatagatc  78240
ccgcattact gattttaaag aaacccggac aacgcttcaa ggttgaagta ca
#aacaagat  78300
atcatgctac aggtcaatgc gaaccgtggt gtcaagtttt cgccgcgtac at
#tcccgata  78360
acgccttaac aaatctctta ataccaaaaa cggaaccatt tgtttcacac gt
#tttttcgg  78420
ccacgcataa ttcaggggga ttgattttat cattgcctgt ttatcttagc cc
#cggtttat  78480
tctttgatgc atttaacgtt gtagcgatac gaataaatac tggaaaccgc aa
#gcaccgtg  78540
atatttgtat tatgtatgca gaactaatcc caaacggaac gcgttatttt gc
#tgatggac  78600
aacgggtact tttattatgc aaacagctga ttgcgtatat ccgatgcacc cc
#tcgtcttg  78660
catcgtctat aaaaatatac gcagagcata tggtggcagc catgggtgaa tc
#acacacgt  78720
caaatgggga caatattgga cccgtttcat ccataatcga tcttgatcga ca
#gttaactt  78780
ctggaggtat tgatgactcc cctgctgaaa cacgcataca ggaaaataat cg
#ggacgtcc  78840
ttgagctaat aaaacgggcc gtaaacattg ttaactccag gcaccccgtc cg
#accttcta  78900
gttcccgcgt tgcatctggg ttgcttcaaa gtgcaaaggg ccacggagcg ca
#aacttcca  78960
acacagatcc gatcaataac ggttcctttg atggcgtcct tgagccgcct gg
#acaagggc  79020
gatttacggg aaagaaaaac aattcgtccg ccagcatccc acctttacaa ga
#cgttctat  79080
tgtttacccc agcttcgaca gaaccccaaa gtcttatgga atggttcgac at
#ctgttatg  79140
cccaattagt tagcggggac actccagcag atttctggaa acggcgtccc ct
#atcaattg  79200
taccgcgaca ttacgcagaa tcccccagtc cgttgattgt agtatcttac aa
#cggatcct  79260
ctgcctgggg aggacgtatt accggaagtc caattttata tcactctgca ca
#ggctatta  79320
ttgatgctgc gtgtataaat gcccgggttg acaatcccca aagcctacat gt
#gacagctc  79380
gccaagagct agtcgcgcgt ttaccgtttt tggctaacgt cctaaataat ca
#aaccccct  79440
tacccgcctt taaaccaggc gccgaaatgt ttttaaacca ggtatttaaa ca
#agcgtgtg  79500
tgacatcgct aacccaaggt cttataacgg agttacaaac gaacccgact ct
#acaacaac  79560
tcatggaata tgatattgca gattcttccc aaacggttat tgatgaaatt gt
#agcccgca  79620
caccagacct gattcagact atagtttcgg tgttaacgga aatgtcaatg ga
#tgcgtttt  79680
ataacagctc cttgatgtat gcggttttgg cgtatctgtc atctgtatat ac
#acgaccac  79740
aaggtggggg gtatataccc taccttcacg cttccttccc atgctggtta gg
#taatcgtt  79800
ctatatattt atttgactat tataattcag gaggggaaat acttaagctt tc
#caaggtcc  79860
ccgttcccgt agccttagaa aaggttggta ttggtaattc cacacaactg ag
#gggtaaat  79920
ttatacgcag cgcggatatt gttgatattg gaatttgttc taagtattta cc
#cggtcaat  79980
gttacgcgta catttgtcta ggatttaacc agcaattaca atccatttta gt
#tttaccgg  80040
ggggatttgc ggcatgtttt tgtattaccg ataccctaca ggcagcacta cc
#tgcatcgt  80100
taatcggacc tattctagac agattctgct tctctattcc caacccccat aa
#ataaatta  80160
gtgtcactat aaaaacataa caccagaatc tcttcatatt taattttacg tc
#atttctcc  80220
cgtttccacc ccctcttaaa atataaaata accgggtggg tggcattaaa cc
#cacaagta  80280
cccgggcggc aatccgctag actgtttttc tgctcatgga attacaacgc at
#atttccgc  80340
tgtacaccgc tacgggtgca gcgcgcaaat taacccccga ggcagttcag ag
#actctgcg  80400
atgcattaac gctggatatg ggattatgga agtccatcct gaccgatccc cg
#ggtgaaaa  80460
taatgcgatc aactgctttt ataactttaa ggatcgctcc gtttatcccc ct
#tcaaacgg  80520
atactactaa tattgccgtt gttgtagcca caatttacat cacgcgccca cg
#tcagatga  80580
acttacctcc gaagactttt catgtaattg taaattttaa ttacgaggtc tc
#gtacgcaa  80640
tgacggcgac tttaagaatt tatccggttg aaaacataga ccatgttttt gg
#agcaacgt  80700
ttaagaaccc gatcgcgtac ccccttccaa catctattcc ggatcctcga gc
#agatccca  80760
cccccgcaga tcttacacca acgccaaact taagcgacta cttacaaccc cc
#gcggcttc  80820
cgaaaaatcc atacgcatgt aaagttattt ctccgggagt gtggtggtca ga
#cgaacgaa  80880
ggcgtttata tgtactggct atggaaccta atttaatagg gctatgtccc gc
#cggatggc  80940
atgctcggat acttggctct gtattaaatc gactcctcag ccatgcggac gg
#atgtgatg  81000
aatgtaatca tagagttcac gtgggggcac tgtatgcgtt accccatgtc ac
#aaatcatg  81060
cggaaggttg tgtgtgttgg gctccgtgta tgtggagaaa ggccggtcag cg
#ggaattaa  81120
aagtggaggt agacattggc gctacgcagg ttctttttgt agatgtcacc ac
#ctgcattc  81180
gaattacgag tactaaaaat cctcgcatta ccgcaaatct tggcgacgtt at
#agcgggaa  81240
ccaacgccag tggtctctct gtaccagtaa attcatctgg gtggcagctt ta
#tatgtttg  81300
gagaaacatt aagccgggct attattaacg gctgtggtct gcttcagcga at
#ttgcttcc  81360
ccgagacaca aagattatcg ggtgaaccgg aacctacaac cacctagtat ac
#cttaactc  81420
aaccgccgtt gtggaaaggt atatgtcaac atttacagta atatattaaa gg
#ttaaattt  81480
ataaaacact cacgtttgtg ttgtgacttg acgcgaacac cgctgtgctg ta
#agacccgt  81540
cggtaaatga aaacgtaata gattcgcctt ttacatgatc cacgtaattt gc
#cccaaacc  81600
actgttccag gcgagacttg ataccctcaa acacgggttc cgttgctttg cg
#tatatgag  81660
ccgtataacc cactttaatt cctctaaacg tggccattac taaagctatt aa
#tggtacaa  81720
gaaaccatgt tttcccatgt ctacgtggta ccaaaaacac agttgatttt tg
#tttgaagt  81780
gttctaaaac actgtcagaa acacttggcg tgttaaacac tgtacgcaga aa
#gcagtcaa  81840
ctctgtcggc atgatcgccc aatagcaccg atgaaataaa atgcgtggtg tg
#catgagga  81900
tcattttttg aaacagttcc aacgtcccct tatatctgcc atagattgga ac
#gtcaacct  81960
ttgcgcgttt gccatgactt ccacactctt caatactctc aaaagatgtt tc
#cacaaggt  82020
acgaaaaccg ttgtgtaaag gtagacaact gacagaaact atccgacaga ga
#aaacgcgc  82080
gaaatgtgtt cataacaccg ctatacgcat ttcgatgagg tgctgcttct tc
#cggtgaat  82140
attcataaaa ctgtacacta ctgacagcct tttttaattc rgggcttacg tt
#tgcattta  82200
ccgaatatcg ccatggtttc aaaactacat tgggggtaca gttgtaccct gt
#tgacgata  82260
gaaacgcgcc aaacattgcc cgtcgagcag tagccgagaa cagtggaata ta
#ttcacaac  82320
agttgtgaag cgttccaatt ccgggaataa cggcctgatg acgtcgggtt ac
#atctatag  82380
caaaattcag aaacgggatt tgggttgcgt ttcccagaga cccttgccgc gt
#ggaacacg  82440
gggtagggga ctccaacgtc ccaaagcgtt catccctacg acgctttaga cg
#ttcaaaat  82500
atcttacaga ttcttcacca agcgtacgac caaacattat caatgacatt ta
#acatcaat  82560
tcacggaatc cgcctcatct cttgtaagca gtaaaacagg aagccgcgtc at
#cttacgta  82620
ctcgttacgt atatatcata aacattttca gggccgcatt cattcacttt gg
#tcatgtca  82680
ggccacactc caacctacgc ttctcatagg cgtaaccgtg tcaaactagt tg
#aggcgcat  82740
aaccgcgcgg ggttatttaa agaacggacc ctcgatctaa tccgtggggg tg
#cgagtgta  82800
caagatccag catttgtgta tgcctttact gctgcaaaag aggcctgcgc cg
#atttaaat  82860
aaccagctcc gctctgcagc tcgcatagct tcagttgaac agaagattcg tg
#atatacaa  82920
tccaaggttg aggaacaaac aagtattcaa cagattttaa atacaaacag ac
#gctatata  82980
gcacccgatt ttattcgcgg tttggataaa acagaagacg ataataccga ta
#atatagac  83040
agactggaag acgcggtagg accgaacatc gaacacgaaa atcatacttg gt
#ttggagaa  83100
gacgacgaag cgttacttac acaatggatg ctgacgacac accccccaac ct
#ccaaatat  83160
ctccaactgc aggacctttg cgttcccacc acaataccga cggacatgaa cc
#aaatgcaa  83220
ccgcagccga tcagcaagaa cgagaatcca ccaaccccac acacggatgt gt
#aaatcatc  83280
catgggccaa tccgtcaact gcaacatgca tggaatcacc agaacgatca ca
#acagacaa  83340
gcttattttt attaaagcac ggcttaacga gagatccaat acatcaacgc ga
#aagggtgg  83400
acgtttttcc acaatttaac aaacccccat gggtttttag aatttccaaa tt
#atcccgtt  83460
taattgtacc catcttcacg ctcaatgaac agttatgttt ttctaaatta ca
#gattcgag  83520
atagacccag gtttgcggga cggggaacgt atgggcgtgt tcatatatac cc
#atcgtcaa  83580
aaatagctgt aaaaaccatg gacagtcgtg tttttaatag agagttaatt aa
#cgcgattt  83640
tagcgagtga gggttctata cgagcagggg aaaggctagg tatttctagc at
#agtttgcc  83700
ttttaggttt ttcgttacaa accaaacagc tactgtttcc ggcatacgac at
#ggatatgg  83760
atgaatacat tgttcgcctg tccagacggt tgacaatacc tgatcacata ga
#cagaaaaa  83820
ttgcccatgt atttttagat ttggctcaag cgttgacgtt tttaaatcga ac
#gtgcggcc  83880
tgacccacct agatgtgaaa tgtggcaata tttttcttaa cgtcgacaac tt
#tgcctcgt  83940
tggaaataac cacagcagta atcggagact atagcctagt aacattaaat ac
#gtattccc  84000
tttgtactcg agcgatattt gaagttggaa atccatccca cccggarcac gt
#actacgcg  84060
taccccggga tgcatcgcag atgtcatttc gtttggtgtt gagtcatgga ac
#aaaccaac  84120
cccctgaaat cttgcttgat tatattaatg gaacgggcct tactaaatat ac
#tggaacct  84180
tgccccaaag agttggactt gcgattgatc tttatgcatt gggccaagca ct
#cttagaag  84240
ttatcctgct aggacgtctt cccggacaac tgcccatttc agtacatcgg ac
#cccgcatt  84300
atcactacta cggtcataag ttatcaccag atttggcgct tgatacgctg gc
#atatcgat  84360
gtgtcctggc gccatatata ctcccatctg acatccccgg ggacttaaat ta
#taatccct  84420
ttatacacgc cggagagctg aacacccgta tttcccggaa ttctttacgc cg
#gatattcc  84480
agtgtcacgc agtgcgttac ggcgtaacgc actcaaagct tttcgaaggc at
#acgcattc  84540
cggcctcatt atacccagcc actgttgtta cgtcgttgtt gtgtcacgat aa
#ttcagaaa  84600
tacgctcgga tcacccttta ttatggcacg atcgggattg gataggatcg ac
#ataagccc  84660
ccagccagcc aaaaaaattg cccgtgtggg aggtctacag cacccttttg ta
#aaaacgga  84720
tattaacacg attaacgttg aacaccattt tatagacacg ctacagaaga ca
#tcaccgaa  84780
catggactgt cgcgggatga cagcgggtat ttttattcgt ttatcccaca tg
#tataaaat  84840
tctaacaact ctggagtctc caaatgatgt aacctacaca acacccggtt ct
#accaacgc  84900
actgttcttt aagacgtcca cacagcctca ggagccgcat ccggaagagt ta
#gcatccaa  84960
attaacccaa gacgacatta aacgtattct attaacaata gaatcggaga ct
#cgtggtca  85020
gggcgacaat gccatttgga cactactcag acgaaattta atcaccgcat ca
#actcttaa  85080
atggagtgta tctggacccg tcattccacc tcagtggttt taccaccata ac
#actacaga  85140
cacatacggt gatgcggcgg caatggcgtt tggaaaaacc aacgaaccgg cg
#gcacgagc  85200
gatagttgaa gcattgttta tagatccggc tgatatccgt actcctgatc at
#ttaacgcc  85260
agaagctaca actaagtttt ttaattttga catgctcaat accaaatctc ca
#agtctcct  85320
tgtgggtaca ccaagaatcg gaacgtatga atgtggactt ttaatcgacg tt
#cgaacggg  85380
acttataggc gcgtcgttgg acgttcttgt atgtgacagg gaccctttaa ct
#ggcaccct  85440
aaatccccac cctgcagaaa ccgacatttc attttttgaa attaaatgtc gt
#gctaaata  85500
cctctttgat ccagatgata aaaataaccc gctcggtcgg acgtacacca cg
#ttaataaa  85560
tagacctaca atggcaaatc tacgggactt tttatatact ataaaaaacc ca
#tgtgtaag  85620
cttctttgga ccctcagcaa acccaagtac acgcgaggcc ttaataacgg at
#cacgttga  85680
atggaaacgt ttaggattta aaggtgggag ggcccttaca gaactcgacg cc
#catcattt  85740
gggcctcaat cggacaatct catcccgagt gtgggtattt aatgatccgg ac
#atacaaaa  85800
ggggacaatt acaaccattg catgggccac tggagatacg gctcttcaaa tt
#cctgtatt  85860
tgccaatccg cggcacgcta actttaaaca aattgccgta caaacctatg ta
#ttatccgg  85920
ttactttcca gcgctaaaac tacggccctt ccttgtcacc tttataggac gt
#gtgcgccg  85980
accacacgag gtgggagtcc cattgcgcgt cgatacacaa gcggctgcca tt
#tacgaata  86040
taactggccg actatcccac cccactgtgc ggttccggtt atagccgttc ta
#acgcctat  86100
cgaagttgat gtgcctagag tgacaaaaat acttaaagac acaggaaaca ac
#gcgattac  86160
atcagcattg cggtcattgc gatgggacaa tcttcatcca gcggtcgagg ag
#gaatctgt  86220
ggattgtgca aacggtacaa cgagcttgtt acgtgcaacg gagaaaccgt tg
#ctttgaac  86280
tcagagttct ttgaagactt tgactttgat gagaatgtaa cagaggacgc cg
#ataaatcc  86340
acacaacgcc gcccacgagt gatcgatgta acaccaaaac gaaaaccttc gg
#gaaagagc  86400
tcccattcca aatgcgcaaa atgttaaacc ctgataaacg ttctaataaa aa
#catcaaat  86460
catggttggt tactgtgaat gtttgtttta ttgcttgggg ggttacaagt ac
#aacccacg  86520
ctactcccac ccactgtttg atcgctcgta taacagctca tcctcgcggt cc
#gtttcata  86580
tgttgagtca ttttcataga cgtagccgta gccttgtgat gggtaatttg tg
#cggcgaga  86640
atttctatgt gcaggtttta cttttcgtat gtatccccgt acccgctcgg gt
#actcttct  86700
tacggcaccg tagaaccgac tgcgtttctg tcgatgatac acatatgcac gc
#atcaatct  86760
gagaagcaac atgacaacgg aaaacacggc caggcaagcc aaggttcccc ga
#gttgtggg  86820
aattaaccgt ggagattgaa ccgatatagg gtcatataat cggtccatat ac
#gagtgcgc  86880
ggcggttccc aacgtagcac aggccacgag cgttcccagg gacggtccta tt
#aacacgtg  86940
tatataatgc gccaaaatta attctgatac tataagatat acaactgaca at
#gtactaaa  87000
tgtagacatg gccacggaca ccgatgacca cagtcccgta tgtagatgat tc
#gccaccac  87060
aagttccagc attaatgata caaataggat acatatcgcc atcaacgcag cc
#atcaaatt  87120
cacgaacact gcgcgcgtag gccccgcaag gcgatataaa aagacgctct gc
#tgtcgtaa  87180
atttgcgacc gcttttatgt tcgtttcgtc caattttccg cgtccrcaaa aa
#tacgttgt  87240
aaatattaca cytgtcgcaa aatgtccaag atataatgta gcagccacgc cg
#atttgctt  87300
gtaagctaat aataacacaa cggcgtttaa taaccacaat gacaaaagac cc
#caaaaaag  87360
tgttgtggga tctacaacta accatgcaac accggagctt tgccggacac gt
#tgattttt  87420
cgtttctcgg tgtataatcg cggccgtgat cagtgtatat accgccatgg cc
#attgccgt  87480
taaagccgtg tagtaagtaa atgccacaac gctatgtggt tccaaaaaca aa
#accggggc  87540
gctgtatcca cctctatttc cggaccatac ccccccatct agggtggcgt ta
#aataactc  87600
ataatcaact acggcagcat aaaaacaagg gatcccggta tattcagaag ag
#gcggcaat  87660
taacgtagcc aggagcatta ccgcacccaa agtgaacatc atcacctgaa tt
#atccaaat  87720
tcgccaatta agcgtatcca tttgatgatc taacgcttcc acctcgggtg tc
#gtggtgtc  87780
gtacggtgag actttttcag aacgcggccc cttcttttga gttcccatgt ct
#cccaacac  87840
cggggagagc aacgccgccg tctatgcgtc cagtacacag ctcgcgcggg cg
#ttatatgg  87900
aggggatctg gtttcgtgga ttaaacacac ccacccggga attagcctgg aa
#ctgcaatt  87960
ggatgttcca gtaaaactaa taaaacctgg tatgtcacaa actcgcccgg ta
#accgtcgt  88020
acgtgcccct atgggctctg gtaaaacaac agccttgctt gagtggcttc aa
#cacgcgtt  88080
aaaggcagat attagcgtac tggttgtctc atgtcgccgt agctttaccc ag
#acgttgat  88140
tcaacggttt aacgatgcag gcctctccgg attcgtaaca tatttgacat cc
#gagacata  88200
tattatgggt tttaaacgtt tgattgtgca acttgaaagc ctacaccgcg ta
#tccagcga  88260
agctatcgac agctacgacg tattaatact ggatgaggta atgtcagtga tt
#ggacaatt  88320
atactccccc acaatgagac gtctttccgc ggttgatagc ctattatatc gt
#cttttaaa  88380
tcgctgttct caaattatcg cgatggatgc tacagtaaac tctcagttta tt
#gatttaat  88440
ctccggattg cgtggagatg aaaacataca cacaattgtg tgtacatacg cg
#ggagttgg  88500
gttctccgga agaacttgca cgatcctgcg tgatatgggc atcgacacgc tt
#gtgcgagt  88560
cattaaacga tctcctgaac acgaggatgt acgtaccata caccaactac gt
#ggaacatt  88620
ttttgacgaa ctagcactac gattacaatg tgggcataac atctgtatat tt
#tcatcaac  88680
tttatcgttt tcggagctag ttgctcagtt ttgtgcaata tttacagact ct
#attcttat  88740
tttaaactca actcggcccc tatgtaatgt aaacgaatgg aaacattttc gc
#gtgttggt  88800
gtacactacc gtcgtgaccg ttggattgag ttttgacatg gctcattttc at
#agcatgtt  88860
tgcttacata aagccaatgt catatgggcc ggatatggta tcggtctacc ag
#tcattagg  88920
gcgtgtacgt ttattgctac ttaatgaagt tttgatgtac gtcgatggct ca
#aggaccag  88980
atgcggaccc ctgttctcgc caatgttact aaactttacc atcgcaaata aa
#tttcaatg  89040
gtttcctaca cacacccaaa taactaacaa actgtgctgt gcatttaggc aa
#cgatgtgc  89100
aaatgcattt acacgctcga acacccatct cttctcaaga tttaaataca aa
#cacctttt  89160
cgagagatgc tctctttgga gtttagccga tagcattaat atcttacaaa ct
#cttttggc  89220
ctctaaccaa attttggttg tattggatgg catgggtcca ataacggacg tt
#tccccagt  89280
tcaattttgt gcatttatac acgatctcag acatagcgct aacgccgtag ct
#tcctgtat  89340
gcgttctctt agacaggaca atgacagctg cttgaccgat tttggccctt cc
#ggatttat  89400
ggccgataac attaccgcgt ttatggaaaa gtatcttatg gagtcaatta at
#accgaaga  89460
acaaattaaa gtatttaaag cccttgcatg tccaatagaa cagcctagac ta
#gtcaatac  89520
ggcaatattg ggggcgtgta tacgaatacc tgaagcgttg gaagcatttg ac
#gtatttca  89580
aaaaatatac acgcactacg cttccggttg gtttcccgtc ctggacaaaa cc
#ggggaatt  89640
tagcatcgcg actataacta ccgccccaaa tttaaccacr cattgggagc tg
#tttcgccg  89700
ttgtgcctat attgcaaaaa cactcaagtg gaatccgtcc accgaaggct gt
#gtaacaca  89760
agttttggat acggacatta atacactttt caatcaacac ggggattcgc tg
#gctcaact  89820
aatatttgag gttatgcgct gtaacgttac cgacgctaag attatattaa ac
#cgcccggt  89880
ttggcgaaca accggattct tagatggatg ccataatcaa tgcttccgtc ca
#atccctac  89940
aaaacacgaa tataacattg ctctatttcg tttaatttgg gaacaattat tt
#ggcgcccg  90000
cgtaactaaa agtacccaga cctttccggg aagtactcgt gtgaaaaacc ta
#aaaaaaaa  90060
agatctagaa actttacttg attcaattaa cgtggatcgt tctgcatgtc gt
#acctaccg  90120
ccagttgtat aacctgctta tgagccatcg ccattcgttc tcccaacagc gt
#tacaaaat  90180
tactgccccc gcttgggcac gccacgtgta ttttcaagca catcaaatgc ac
#ttggcccc  90240
gcatgccgaa gccatgctac aattagcgct atcggaactg tccccgggat cg
#tggccgcg  90300
gataaacggg gcggtaaatt ttgaaagttt ataacccatt aataccatat at
#ggacatcc  90360
ataggggggg ttacataaat actaagcctc tgtacaacac aaagggcctc ta
#acaatgca  90420
ctgaaccaca accaagctat ggacgcaacg cagattacct tggttagaga aa
#gcggacac  90480
rtttgtgccg caagcatata cacatcctgg acacagtccg gacaattaac ac
#agaacggt  90540
ctttccgtgt tatactactt attatgcaaa aactcatgtg ggaaatacgt cc
#ctaagttt  90600
gccgaaatta ccgtacaaca agaggattta tgtcgctact ccaggcatgg gg
#ggagtgtt  90660
tctgcggcaa cgtttgcgtc tatctgcagg gcggcgtcct cggctgcgtt ag
#acgcctgg  90720
ccccttgaac cactgggtaa cgcagacacc tggcgttgtc tccatggcac tg
#ccctggcc  90780
actttacggc gcgtattagg gtttaaatcg ttttattcgc cagtaacatt cg
#agactgat  90840
acgaatacag gtcttctgtt aaaaacaatc cccgatgaac acgcgttgaa ta
#atgacaac  90900
acgccatcta ccggagtatt gagggctaat tttcccgtgg ccattgatgt tt
#cagcagtc  90960
agcgcatgta acgcccacac gcaaggtacg tcgctagcct acgcccgcct ga
#ccgcactt  91020
aaatctaacg gtgacaccca gcaacaaaca cctttagacg tggaggtaat ta
#caccaaag  91080
gcctacatac gtcggaaata taagtctacg ttttcccccc ctatagagcg gg
#aaggtcaa  91140
acctccgatt tgtttaacct tgaagaacgc cgcttggttc ttagtggcaa tc
#gcgcaatt  91200
gtggtaaggg tactcttacc gtgttatttt gactgtttaa caacggattc ca
#ccgttaca  91260
tcttcccttt caatattagc aacatataga ctgtggtacg cggcggcgtt tg
#gaaaaccc  91320
ggggttgtcc gtccaatctt tgcgtattta ggcccggaac tcaatccgaa gg
#gtgaagac  91380
agagactact tttgtactgt cggatttccc ggatggacca ctcttcggac ac
#aaactcca  91440
gccgtcgaat ctattcgcac ggctacggag atgtacatgg aaacggatgg gt
#tgtggcca  91500
gtaaccggta ttcaggcctt tcattatcta gccccctggg gacagcatcc cc
#ccttacct  91560
ccgcgggtgc aggatcttat tgggcaaatc cctcaagata ctggacatgc ag
#atgcaact  91620
gtcaattggg acgcgggccg gatatctacc gtcttcaaac agcctgtaca ac
#tacaagat  91680
cgttggatgg caaagtttga tttcagcgcc ttttttccca cgatatactg cg
#ctatgttc  91740
cccatgcatt ttagattagg caaaatcgtc ctggctagaa tgcgtcgagg aa
#tggggtgc  91800
ctaaaacccg cgttggtgtc tttttttggg gggttacggc acatactccc ga
#gtatatac  91860
aaagctatta tttttatagc caatgaaatt agcctttgcg tcgaacaaac gg
#ccttggaa  91920
cagggctttg ctatatgtac ttatataaaa gatggatttt ggggaatctt cg
#ccgattta  91980
catacgcgca atgtatgttc agatcaggca cgttgttcgg ccttaaattt ag
#cggccgcc  92040
tgcgaaagag cagtcacggg cttattacga attcaactag gtcttaactt ta
#cacccgcc  92100
atggaaccgg tactccgggt cgagggtgtg tacactcacg catttacctg gt
#gtaccacg  92160
ggaagctggc tgtggaattt acaaacaaac acgcctccgg atttagttgg cg
#tgccatgg  92220
cgaagtcagg cggcgcgaga tttaaaggag cgtctttcag gactcctatg ta
#ccgcaaca  92280
aaaattcgag aacggataca ggaaaattgc atatgggacc gtgtcctata cg
#acatatgg  92340
gccggacaag ttgtggaggc tgccagaaaa acatacgtcg atttttttga ac
#atgttttt  92400
gatcgccgtt atactccggt atactggagt cttcaggagc aaaattcgga aa
#caaaagca  92460
ataccggcat cttatctgac atacggacac atgcaagata aggattataa ac
#caagacag  92520
ataattatgg ttcgtaatcc caacccacat ggacctccta ctgttgttta ct
#gggaattg  92580
ctaccatcgt gtgcctgtat tccccccata gactgcgctg ctcatctcaa gc
#cccttata  92640
cacacgtttg tcactattat taaccatctt ctagatgctc ataatgattt tt
#caagtcca  92700
tcattgaaat ttactgacga tccccttgct tcatataact tcttgttttt at
#gacaaaaa  92760
aacacgccgc aacaacccat ccttaaaata aaaggtttat ttactttaca ac
#ccgtggtg  92820
aatttttata cgtttcaaat aactgaacat ttttcggtgt taccatggtg cg
#atttaacc  92880
accaaaaata tacgctcttc tgatattccg aatctcgtaa aggtccattt aa
#caatcccg  92940
ggggcacttg caccacacca tctggacagg ggggggttcc gtggggcagg tc
#aaaacgct  93000
gacccacccc acatgaatat atagccttta taatattggg ggccgttcca gg
#ctgagggt  93060
tcagtaactt aacaaacata taatgcggca atacgcgggt ttttgtaaag gg
#gttgttat  93120
caacgacata cattagagtg tttaacaacc ataaaactcc ctcatataaa aa
#ccgacgca  93180
ttttttccaa aggtcctatt tgacactcaa cgcgtctaag atatacagac aa
#ttgtacaa  93240
acagcgatgg agatgccccg gagggcccaa tgccttccag atacattaaa at
#aacacata  93300
aggtaaaatc taggacatta tccgggcgga atagagtcat ccgatagatt aa
#caggcgcg  93360
gaggcacccc caccgtatac accctatctt caaccgcagt taatacggaa aa
#aataaatc  93420
cgcggaacgc tggttgagta acacactcca tgtagtaacg atcacaggac ac
#ctcacttg  93480
aatcaccatt caacactact aaaacggtct cttggtgttc cggttttacg cg
#cagtgata  93540
caacagagtt tgccaaaaag cgtggcttca aaccggttac ctcccgcgcc tc
#gcatacga  93600
atcttggtat tgcttgtatt ctaagatctt cgatcacgtc gctcacatcc aa
#cccctctt  93660
cggctcgtgt tagtaagttg tcgatcgtta cgctgcaacc taaaatgctg gg
#tatattta  93720
ttccggacat cccatcggcc atccccgcgc ctccggtttg ctcgaatttt at
#ccagtaag  93780
gtcgaatccg ctgcatttac cttgtgtacc cgtaacctct caggggggtg tc
#ctttcata  93840
aaatgggata ggtttttata tccaacatgc atgtattggt tatttatttt at
#tgggttcc  93900
gggattcttt cgtcatcttc tgtagggtca ggcaaacccc aggaaggact tg
#gtgttctc  93960
cgtgggcccc gttttattac ctctgcgcga acctgcattt catataatat tc
#ggatttgg  94020
gataaatagg actctgttct cgccttttta aaaatagcct ggcataactc tt
#cctctgac  94080
ctatgtacct cgctttgagt taccaagaat cccaatcggg tggcccgtaa ta
#tgaatgaa  94140
aaatacggcg caactagtaa tgagattgac gcatttgaat atgatacaga aa
#tttcctgg  94200
ccttgattat tgtttacccg gtgaagctta aaacagcgaa caagttcctg tt
#tccatagc  94260
tcagacaaac gttttatatc atctccataa ggggggatat aacgagattg aa
#aactattg  94320
gcaatatatg catcatcccc tattatgccg gtaagatcta taacctcgtg at
#ttaaatcg  94380
gcaatacgtg tttcttctgc cattgtaata tgtgaccctt tagatggctt ta
#tttttacc  94440
ctctcttccc gtaaccgttt cagctctcct tctttgaact ggagcctttc gg
#tcagatcg  94500
ctgttcacat ccttgagacc ctcaatggtt ttgaataaat tattcacata ac
#cctcgagc  94560
atgccgttga tactgttgac caccgatgtt ttaaacgcac tttgaacgtt tg
#ttgttccg  94620
gacattgccc ccccgttaaa ggattggttg gccttgccaa accccggttg tg
#atgtgtcc  94680
accgatccac ttccttccag aatgtgattg cccgtttctt ctagatagga ac
#gtacggtt  94740
tcggtaatat ctccaacatg tctcatgttt tttaagttaa ctattagctt ta
#caagtcta  94800
gacgcggccg atccagcccg tgttgtatcg ttctcgccca ttatacgatc aa
#ccgcacgt  94860
gtgctgtgag atctatcatc ttcattccgg cgacctatta acacgcgcaa ag
#gggctgta  94920
tttaaaactt ggcagacgcg agcatgttca cgtaatgcat aacaggccaa ca
#cctcccca  94980
gaaagccgct gtaagggtga gtcaaatact acaccctccc cacatacaac gg
#gcggccac  95040
acgaccaaac actctccctt catgcccgtt acatcatcct ttgccataat ta
#atcttcgg  95100
ttataattat aataaagacg cgtcctatca taatccataa tagcaacatt tt
#gcatacac  95160
tcaactaggc ttgtgacaac cgccgcccct ctggccaacg ttgcatcggc aa
#cttttaac  95220
atctgggaca gttctgccgc ttgacccata tacgtattta atggtgcagg gg
#ttccattc  95280
tgttctgatc gtacctttct tacaacgggc acaataccta cacaggctat cc
#agtccacg  95340
tatttggcaa aaccgaccct tccatttaaa ccactggtat agagacaacc gg
#ttattcca  95400
cgcagaaact caagtaacga tgactgtaat gtttgacgcc aggtttcaaa aa
#cctgatgt  95460
gcaagccgta cggcttctga ttctccacat aacccataac gttccgctag ag
#ccccggca  95520
tgcaggttac attgttggat gtggtggtcc caatctgctg ctaggtcctc at
#accgagtt  95580
gcatccaacg cgttcatcaa aacggttgcc tgaacttggc gaattacagt tt
#ccgtagac  95640
cgtacagcgc tatatatgcc ttgtccatcg gtatatccaa agtcaccggc ta
#ggattttt  95700
cgaaacaaca tactttgcgt ggttgggtgt attaacatcc agccatcttc ct
#ccggaaat  95760
gtacaaaacc ctatatccgg ggcgtactca ttccagtata tatcgaacat gt
#tcttgtat  95820
tggtcatttg ggttacttcc attcaagccc tggtcaatag aaacagaact tg
#ctatcctt  95880
ttttcttcac taccggaact gttattaaaa agagacgtta tttcggccat tg
#aaaaccac  95940
gatgaaaaga tcaatttctg tagacagttc ttcacccaaa aacgttttta at
#ccagagac  96000
gcccaatgga tttgatgaca gtgtatattt aaacttcacc tctatgcata gc
#attcaacc  96060
tatcctctca cggattcgag aacttgccgc aattacgatt ccaaaagaac gt
#gttccgcg  96120
gttgtgttgg tttaaacagt tactcgaact gcaagcgcct cctgaaatgc ag
#aggaatga  96180
gctccccttc tccgtttatt taattagcgg aaatgccggc tccggaaaaa gc
#acgtgtat  96240
ccaaacgctt aacgaagcta tcgattgcat tattaccgga tccaccaggg tt
#gctgccca  96300
aaatgttcat gctaagttat caacggctta tgcgagtcgt ccgataaaca ca
#atctttca  96360
tgaatttggt tttcgcggaa atcacattca ggctcagctg ggccgttacg ca
#tataactg  96420
gactacgacc cccccttcta ttgaggacct gcaaaaaaga gatattgtat ac
#tactggga  96480
agttttaatt gatataacaa aacgagtgtt tcaaatgggg gacgacggtc gc
#ggaggaac  96540
atcgacattt aaaaccctgt gggcaattga acgtttgctt aataaaccta ca
#ggctcaat  96600
gtccggaacc gcgtttatcg catgcggttc ccttccggct tttacccgga gc
#aacgttat  96660
tgttattgat gaagcaggat tgctagggcg tcatattctc acggccgttg tt
#tactgttg  96720
gtggcttttg aatgctatat atcaaagccc tcagtacata aacggtcgaa aa
#ccggtcat  96780
agtatgcgtc ggttcgccca cccaaactga ctcgttagaa tctcattttc aa
#catgacat  96840
gcagcgttca cacgtaactc ctagtgaaaa tatactcacg tatataatct gc
#aatcaaac  96900
tctgcgtcaa tatactaaca tctcacataa ctgggcaatc tttattaata ac
#aaacgatg  96960
tcaagaggac gattttggaa atcttttaaa aacgcttgag tacgggctac ct
#attaccga  97020
agcacatgcg cgtctggtcg atacatttgt tgtacctgca tcctatatta ac
#aatcctgc  97080
taatctcccc ggatggacgc gtctgtattc gtcgcataag gaggtgagcg cg
#tatatgag  97140
taagttacac gcgcatttaa aactatcgaa aaatgaccat ttttctgtgt tt
#gccttacc  97200
gacttataca ttcatccggc taacggcatt tgatgaatac cgcaaattaa cg
#ggacaacc  97260
cggactttct gttgaacatt ggatacgggc aaactccggt cgtttgcaca at
#tattccca  97320
aagccgagat catgacatgg gaacagttaa atacgaaaca cattcaaatc gc
#gacttaat  97380
tgtagcccgt acagacatca cttacgtgct aaatagtctc gtagttgtaa cc
#acaagact  97440
acgtaagtta gttattggat tcagtggtac atttcaatcg tttgcaaagg tt
#ttacgtga  97500
cgactccttt gtgaaggctc gaggagagac atccattgaa tatgcttacc gg
#tttctgtc  97560
aaacctaatc tttggaggct tgattaactt ttacaatttt ttgttaaata aa
#aacctaca  97620
tcccgataag gtatcgttag catacaaacg gttagctgcc ttaaccctgg ag
#ttattgtc  97680
tggaacaaac aaarccccct tacacgaagc agcggttaat ggggcgggtg cc
#gggattga  97740
cygtgatggt gcagctactt ctgccgataa agccttctgc tttaccaaag cc
#cccgagtc  97800
caaagtaacg gcctccatac ccgaagaccc ggatgatgta atttttacgg ca
#cttaacga  97860
cgaggttatt gacttggtat actgccagta cgaattttcc tatcccaaat ca
#tccaatga  97920
ggtccatgct cagtttctgt taatgaaagc tatttacgat ggtcgatatg cc
#atattagc  97980
agagcttttc gaaagcagct ttacaaccgc cccctttagc gcgtatgtcg at
#aatgttaa  98040
tttcaacgga agcgagcttt tgatcggcaa tgtgcggggg gggctgttat ct
#ttggcatt  98100
acaaacagat acgtataccc ttttggggta tacttttgca cccgtgccag tc
#tttgtaga  98160
ggaactgacc cgaaaaaagc tgtaccgcga aactaccgaa atgttatatg ct
#ctacacgt  98220
acctcttatg gtcttacagg atcaacatgg gtttgtgtcc atcgtaaacg ct
#aacgtatg  98280
tgaatttacc gagtctatag aggatgcaga attggcaatg gccaccacgg tg
#gactatgg  98340
ccttagttct aaactagcca tgacaattgc acgctcacag ggcctgagtt ta
#gagaaggt  98400
agctatctgt tttacggcgg ataaactgcg cctaaatagt gtgtatgttg cc
#atgtcgcg  98460
tacggtctcc tctaggttct taaaaatgaa tctaaaccct ctacgggaac ga
#tatgaaaa  98520
atccgcagaa attagcgatc acattcttgc cgctctacgt gatcccaacg ta
#cacgttgt  98580
gtattaaagc attgtataaa aacacgcatg cgggcttgct gttctcattt ct
#aggttttg  98640
tcttaaatac acccgccatg agcatctctg gacccccaac gacgtttatt tt
#atataggt  98700
tacatggggt caggcgggtt cttcactgga ctttaccgga tcatgaacaa ac
#cctctacg  98760
catttacggg tgggtcaaga tcaatggcgg tgaagacgga cgctcgatgt ga
#tacaatga  98820
gcggtggtat gatcgtcctt caacacaccc atacagtgac cctgctaacc at
#agactgtt  98880
ctactgactt ttcatcatac gcatttacgc accgggattt ccacttacag ga
#caaacccc  98940
acgcaacatt tgcgatgccg tttatgtcct gggtcggttc tgacccaaca tc
#tcagctgt  99000
acagtaatgt ggggggggta ctatccgtaa taacggaaga tgacctatcc at
#gtgtatct  99060
caattgttat atacggttta cgggtaaaca gacctgacga tcagaccaca cc
#aacaccaa  99120
ccccgcacca gtatacatcg caaaggcggc agcctgaaac caactgtcct tc
#accacaac  99180
cggccttttt cacatcagac gacgacgttc tttcgttaat attacgggac gc
#cgcaaacg  99240
cgtaaagaca gattcaagac taacatttat cccaactgat tacatttcat ac
#gcgaataa  99300
acgacacaaa aaatttatat ttaacggctt ttaatttgaa gacacctatc ct
#cttaacgt  99360
tgaggagcct tgcaggttgg gtgccgcgct tcaccggtat tatacataac cg
#atttaccg  99420
tgtttacggc agtctgacca tttaccagtg tatgtctgta atacgacgtt gt
#tgtgtccc  99480
gacaaaatta actcgcgtac aaatttctga tgttcccccg gcgtggcaac gc
#tggcattt  99540
ccaaacacat tacgttctcg tacgtccatg accgctattt tcagtattaa tt
#ggttggtc  99600
ggtcaaagta ttttccttat gtaaaaggac acgatctaaa gccgtaaact cg
#tacacaaa  99660
cactggtacc aacggacgcg attttccgtc cgttgagcgg gtgtaatatc gg
#cgaggtct  99720
tcttgcacga atactctcgt acagtaggtt tctgacacgg ggtgcatggg tt
#ttttgaca  99780
caacacaaac atttgcaggc tcttatgact ggatggattg aatttatttt ta
#gatagggt  99840
cacgtgtttt tgtcgtgaca cgcctcgacc agaaaaggct gcggttttcg ta
#cacgcgac  99900
cgttatttca caggcgttca taatcaagct gcggcggatg gtgtcggtta at
#tgtctccg  99960
cccaagttcg tcaatagatg ataccatgaa caacgtatca aatggtacat ag
#tcgtcttt 100020
ggttttctca atacagcccg cgtgcccaat cggaaaattt tcatttgcat ca
#acgctatt 100080
ttctgtaaaa tcggtctgaa cactgtgttg gctggctacc tgtttaaaat tt
#gggatcga 100140
acacggtcca cgatgcaatc cccaacccca ttgaagcaat gccgtcggta cg
#gaaggagg 100200
caactccgaa aacattatgg tacgcgagag ggtcgattgg agtgttatat aa
#cactccaa 100260
tcgatctcgg gttcgccttt acgcgtaaaa tactcattgg cttgaacgaa at
#gtcgacaa 100320
ttccgaaatg gaacacggga caatggcgac ggatgcgcgt gtgttagcac ca
#gatgacat 100380
cttgaattcg gttgggttgt cttctgtgca tgcgcacccc acagcataaa aa
#ctaaccct 100440
gtacggttct cgcataacct ctgtagcacg cgttgcacca gccgccccca gc
#ctaagtat 100500
acatgcgacc ccggagtccc gcgacgaacc gtaagcgtgg tattcagcaa ta
#acaccccc 100560
tgccttgccc aactctccag gcatccgtga gtgggcggag tcatatttgg gt
#atgattcc 100620
atgagggccg caaaaatatt tttaagacta gacggtggtg ttatgccacg tt
#ttacacta 100680
aacgctagcc catgtgcatg tcccgcggta gggtatggat cttgaccaat aa
#ttacaacg 100740
cgaatgctct ggggtccgca aaatcgcgtc catgcaaaaa tatcgcctgt ag
#atggaagt 100800
atttcttccc ctgaatttaa aagacgattg tattctaaaa aaataccttt cg
#cgtacggc 100860
tctttaagtt cgtccgacaa caggtcatac cactcagggg aaatgttaaa ct
#tgctgaaa 100920
acttcaaccg aatccagttg cgaagagacg ggggtgaacg tttccgtgtc gt
#aatgatgt 100980
gacatgttat ttaacttgaa ggttgggggg tctagcttaa cccccaaagg cr
#gcccgcgg 101040
ggtcgcttgc gggttttttt ggtaaccgga tgggccaaaa cataaatgtc ct
#ttgaatcc 101100
gatagtttca tttcattggc atacgcgttg gaacaaacgg tcggctcccc ag
#acacatcc 101160
attttccggg atatttgtgg aagatggagt agagtctacc catacaccgg aa
#agggcatc 101220
caacaaagca tcgcgtatgt ccccgctttt atgttcttca ccaacagatt gt
#gtcagccc 101280
ctttaaggtg acgtatggat ttgtccagta cgccatttgt ttgtctttaa ac
#caaagtat 101340
aacttccggt actggacatt ttgtcttaac cacgattccc gatagcgcct cg
#ctgaggtt 101400
tgataccggg ggtgccgcat agtcccacgc ctcatatacc gatgacacgc ac
#ggttccgt 101460
tataatcaaa ctcacatccg atagcggttt ggctccaaaa aacaacggag tg
#tcgtcttg 101520
gagatgaaga caatacgcga ttgtgatagt ttttaaaaaa actatcatct gc
#agtaacca 101580
tttatgtgat gccatgacgc ttgtgttttc ccttcactac gacgttgtcg ta
#tcctttga 101640
aaaacttgac cactctaatg gaagcatgga caagtatgag ttttatatat ac
#agttggcc 101700
tttagttaaa ctcttggtgt catatctcat tttcctaaaa agggcgatct ta
#atatgtca 101760
aacgtcacgg cgtgccgaca aagcgaattt ccatgcaaga tttggatgta gt
#atttatac 101820
acccaatcac acgtcacgta ttaagcttta cagtcccccg ttatctgata ta
#atcacttt 101880
tcttaacacg tcatcgggaa aacagatgtt tatattatac ctctcgcggt ca
#tttatggc 101940
aaatacttag accgttttca agcggactga aaacgctcaa attgcctttt gg
#aggcctgc 102000
ccaacggcca ttatcccttg gatctaagat tgatttgcgg taacgtttgc ca
#atcaagct 102060
ttaaaaacgt accccaaact taaaacgctc aaattgcctt ttggaggcct gc
#ccaacggc 102120
cattatccct tggatctaag attgatttgc ggtaacgttt gccaatcaag ct
#ttaaaaac 102180
gtaccccaaa cttaaaacgc tcaaattgcc ttttggaggc ctgcccaacg gc
#cattatcc 102240
cttggatcta agattgattt gcggtaacgt ttgccaaacc cacgcatttc ag
#tttaaata 102300
tttctaagca ttcttagtgc gtacttggca gcgtgcttaa aatatcaacc aa
#tatccatt 102360
atgctaaacg tttccttcta tccgtttcaa tccattaaaa gtccattacc aa
#aaatgatg 102420
catcatacct aattcaccta aaaacctgac tcattgcagc agcgtttcct cc
#ttgcagac 102480
tatccagttg gcattttaaa cgggtccggc tgcctgaacc gaaaacaccg tt
#gcctttac 102540
tgtaagtaca aaactaaaat ttatatttgc gtgcgtattt tgtaacatat at
#gcctttta 102600
tccccccgca agtttgcttt accctcgcct tcaccacccc cgccaccttc cg
#gccattgt 102660
aataacttta attgctataa gacataccca aaccggatga tttttgccgc tg
#gaaaaaca 102720
gcttctaatt ttcccgtctc aactcggcct tggttgcatc tccaagtata cc
#tttagttt 102780
gctcccgtag aggtgtataa atacaaacgg tgacaagtat tgagcgtaat ct
#caaatttt 102840
tgtaatttag ggcggagcgc ttacgacagc acatgcgtac tgttagactg tt
#atgtttat 102900
tgtatttgca gagcaggatg ccccggttac tccgagaccg gattgcgggc at
#tccgaatc 102960
gtgtacggac ttaccagggg gcagtattta caccttgggt tccagatata cc
#aaccctta 103020
cgaccaatag caacactcag gtatttttaa aatgcacgtt taatgatcat aa
#tttacata 103080
cagttggtaa taaagcagac cgtggatgtt taaggcattt ccttccccct cc
#caacaaac 103140
taggacttct tcatcttgtt tggaatacct ttacccgctt taccggcaga gc
#tttttttg 103200
gtaaggtgtt tcagtgaacc tgatgttgat ccggaggtgg agggggtatt gg
#actccccc 103260
tgtggagagg caactttgcg ggttttactt cccttacatg ccgaatcaga ct
#cagatgtc 103320
aggtctattg ttaagcatcg tttaacgtct ctgccggtat gaaataaacg gc
#gcttagca 103380
ccccttgcgc ttcccggttt aatccccggt aacacagaaa aaagcctgac tt
#tttggggt 103440
gtatttacca atcgggtatc cctttcatcg ccacgagagg tctccccggt tg
#aggtggtt 103500
tctggtctta caattggacc tgtaattagt tggatggctg tatctttcca gg
#tccaggtt 103560
tgcatggtta ggcgggttgg atcggtacat cgatccaaca agaataacat gt
#ttgttaca 103620
aacggtcctg ttgaatcatg caaaagacaa cgcagggatg tttttaatcc cg
#cctcatca 103680
cgcccgtaaa tacctatata gtttaatatc aacatttttg taggctctac aa
#tttcgggt 103740
tgatacagtt ccgcaagttg atcatcaagc catccgagta aaggttgcat gt
#aacacggg 103800
aatctcgcgt ttccctctgt tcctctatcc gtggctcgaa aaggcagtct gt
#ccatggtt 103860
cgtgggtctt gattaattcc cacagatact ggacgatcac ggtagtcctg cc
#ccccggtc 103920
cggggttgct gtgcagattc aatcgagcca tacaccaccg gggtcgccga tc
#gaacagca 103980
ggttggtctt taaaaaatac cttccgtaaa aatgatgcgg tagagcatgt tt
#tggttaca 104040
ccagggctcg agtctcgggt cggtggttgt atagaatcct gttgagagtc ac
#ttggtgac 104100
tctgctgtgg gctctctagc cgacgattga aggggcccag ggtttggtga tt
#gaatgggc 104160
tcccgactcg atcttgatgt tggctgttgg atggactccc gactcggtcc tg
#ggcttggt 104220
ggcagaagat ctatgacatc tcccggtagg atgtcgatgg aatcttcaaa tg
#acggctca 104280
gaaaaaccat cgtcgtcgga tgggtgcact tcatattcct tgtaacttgt at
#cacttacg 104340
atcttatgca ggatggattg cactggacac cggcagagag gacactggac gc
#tggtggag 104400
gtccatgccc gaatacaaac aaagcagaag tcgtgcaaac acggcatggt tt
#ttccgaga 104460
tcggaaacgg tgctcatgca tatggtgcag gtattatccg aagcgtcgga gg
#tgccgcta 104520
ccgcccgcta atatggtatc catggtaaca actggctgta ttctaatgtc cg
#ggcatcca 104580
aacacgtagc agaactgcca tgcgttctaa attgtgagtt gtggcgagta ca
#tttttata 104640
attggtacca acgaagacac acccctatat ccctccaccc atttctttta ag
#tcccaccc 104700
actaaaacgt gggtataaaa tgtgtattgg ggtaggcgga cagtcccaac aa
#acagggaa 104760
gttgattggt ataaccttgg gccgggtata cagctaagtg acattttaga tt
#ctgtcttt 104820
atttagataa agagcgatac gaagacattt ctccaccccc ctgtaatacc cg
#taaataaa 104880
ggtaagtcca caaacaaaag cactgtatat aggaagtcgg gtgtattggg ac
#agttactc 104940
cattagaggc gtacagacaa tactgggata gggtaatgca agtccccccc ga
#tggtcgcc 105000
ccgcaaacgc gcggggaggt ggggtcgctt ttttttttct ctctcgaggg gg
#ccgcgaga 105060
gggctgggcc cccccccccg gggtccgccg ggcgcccaga aaccgggggg gg
#ttattttc 105120
ggggggggtc cgaccagccc gcccgtcgcc cgcccgcaca gacagacaga ca
#cttttttc 105180
ataaaaaccg ttccgctttt attaacaaac aacaaacagt ccgcgcgccr gt
#ggcgctca 105240
cgagaaaagg aggggactcc gtcacccccg actctgcggg gggctcctcc cc
#ccgcgccc 105300
tccccacaca tcgtcctcgt cctcggagga cgaggacgag gacaacagct cc
#accttgac 105360
cgccgggcgc ragcccaccc ggcggtctcg cagcacaccc ggggccaccg ac
#acgacgct 105420
caccccaaag gatgaccccg gtgcgtcccc gtcgtccccg cccccctcct cg
#ctgtccca 105480
cgcgtcttca caccccacct cccaatcgtc cggctccaaa gcgtgttctc tg
#tcgtctgc 105540
ggtgcgccgc tgtcgccccg cctgggtttc tgccggccgt tccgagcccc cg
#tggtgtcc 105600
gaacgcgaac cgtgttccgt cgctcccctc caacaccgtc tccgcggccc ca
#aaaccggg 105660
cggccacatt actctgggaa tcggggggag ggcattccga gcctcgtccg cc
#gacgcata 105720
cagcgccacc gaccgaccgg ccacgggtgg aagcacgagt ggttccgcgg ca
#gggtcggg 105780
ttccagcagg gcgtggcggc aaaacaccct cgcccaggtg ggtacgtcgc cg
#gcctccgg 105840
cccggcggcc cccggtctcc gtccctcggg aaggaagacg ggtcgaagcg cg
#gcacccag 105900
gccccatcgg tttgctgcgc ggtggctatg tgccgcctcg tccacaaagt cg
#gctgcccc 105960
gagccccaga ccccgagact gtcgcgcgag gtccttgcaa ccgtcaaaac cc
#ggcagcac 106020
gtactgccgg tattcacggg gcgacagggg gacgcgggtc ttggggcccg cg
#cgggtaca 106080
cacggtgtat gcgacgttcc caccgcggca caaacacagg ggttgttcgc cc
#gggtacag 106140
gttggcaaac gcagtctcga tacgagcaaa actcgctggc ccaaaggtgc gc
#gacgatgc 106200
aaacacggcc cgggcgagtc cttctgtgac cgccgagtct ggccatcgga cg
#acggcctg 106260
ggcgtccggt cgcgccgggg cccggacgta cacgtgatac tgagacaaag cg
#ggtccatc 106320
cccgggccac ctctcgaggg ccaccgcgtc caacaccagc aaccggcgcc gg
#gcagaggc 106380
caaccgcgag cctagatact cgacggcccc ggcaaaggcc aggtctcggg tc
#gacagtaa 106440
taaaacgccc cgggcgttca aagcggacac gtccggcggg ccggtccagt tc
#ccggccca 106500
ggcatgagtg ctcggcaggc acaaccggtt actcagggct gccaggacca ca
#gacagtcc 106560
ccctcgggat ggactccatg acggtcccgg atctgtcgcg agggtgctct cg
#agggggcc 106620
gttgatgtcc tctccgggca acggatcgta gatgatcaga agcctcacat cc
#tccgggtc 106680
tgggatctgc cgcatccagg cgcacctccg tcgcagcgcc tccactccgc tg
#ggtggacc 106740
aaaccgtcgg tctcctccgc ccggacgccg agcggcgatt tccgccaagg cg
#ccgggatc 106800
aaagcttagc gcagggcgcc aggccgtggg aaacaatggg tcgtcgacca ga
#cgggcgat 106860
ggtttcgggg gtacagtacg ccttgcgagc ctggtccgac gggaccgggg ta
#tgcagggc 106920
cccccgggga atacgccgaa atcccccgtt tggggccggt ccgtcaagtg gc
#atcgttat 106980
tacggcgggg ggatccacca cagggcccga ggtgatggtc acgggctcgg at
#acccgcct 107040
cttggccttg gaaaccacat gatcgtctgc aacccgggcg tccgcgacgg gt
#gtctccct 107100
aatcttgtcg aggaggcttc tgctctcgac tggctgggac ttgcgcttgc gc
#ggagttcg 107160
taaacgatca tccggtggac acacagaaag agagcgcgcg gcggccgacg gc
#tgagggtc 107220
gggagtctgt gtggccgggg ttgttggaga agggtgaccg cgggagatcc gc
#gccgccgg 107280
actggagccc gttgcctcgg ggtatgccat gccggcaaag gctctgcgga ga
#ctctgtag 107340
gataaagtgt ttttgggccc ggtcgtaccg acggctcata gccacggccg cg
#gccgcgtg 107400
ggggagagcc cagagggcct cccccgtggc catggcttcg cctacatgcg ga
#acgggaga 107460
cgctacgctc cccgtaacgg cggtacccgc ccgtcccggt ggcaacagct tt
#tggtagaa 107520
ctggttcagg gccgagttga caccggtcag cttggggttc tggagccatg ct
#atagggtc 107580
tctgtctgga cagtagatca ggttaatcag cgcgcggtac tgtctagccg ga
#tctcccaa 107640
ctccggcacg taaagcggcr cgggttcagt tgaggcctcg taacgagccc gc
#gccgctct 107700
cacagcctca tcctcccagt gaccctctct ggtctccccg gacggtccaa ac
#cgcaccct 107760
gttggatggg aggggcgccg atccgggcca agggcttccg tcgggcatca tg
#agcggccc 107820
cgacaccggg ggaattatcg gggttctgga tcgcggcagg gaaaatgatt tc
#tgtctctg 107880
gcgccccggt tcccccgcaa gacgtttggt cttacgaatc ctcggatcgg ga
#ccgctgat 107940
ggatcgatat cccggttgga tattttgttt cgtcgaccca ccatcatttg ag
#tccgaatc 108000
atccgaattt gacggggaag gggcgtgttc gcgtccggac ctgctgcctg ta
#gtttcact 108060
tcccaccgaa acgcgccggg gttcatcgtc ttcatcctcc gatgacgatc cc
#cacgacga 108120
ggaagaggat gaagacgaaa caaactcacg actctttggc tttttctcca cc
#gggctgtc 108180
atcctcaatc gggtctggtg cgtgggatct tcccggcagg gccaaaaacg ct
#ctaggttt 108240
gccccccgac gaacgtccag ggacgcgagg tgttataccc cgggcatcat gt
#ttccttgg 108300
gcgggtatca tcggtctcaa acggcaggtc cgcctttgcc cccttagcgg ga
#acgctgtc 108360
cgaaaggacg tggtacaatt gctcaaccgg gccgggtaca ggtccaccgg gt
#ttccgcgc 108420
cgggagtggg accttaacct tcaaagtctt tttcttcggg ctctttccct ga
#gcgggccg 108480
ttgagttttc tggagaacta ctccgtcccc cgatgcatgc gcatgacccg ct
#tgctcatc 108540
gcccggcttt ttacccgaga tggactgagt ttgtctgtct cgatggacca cc
#gacggcaa 108600
acctggtgaa tttcctctcg tcgtttgtcg gggtatagac cgctggtctt cc
#cgttgatc 108660
gttcccggcg gcgtctccaa caggagacgc gggggataca ggggagaagg cc
#tgcgggaa 108720
cggaggggtc gtacctctgc ccgtttcccc atcgttcatc ggtggttttg ga
#gacctagc 108780
aagcttcgtt ccgagagaga ctgtctcgag ggagcgatcg gctcctgttg gt
#tctcgcgc 108840
gccggcctcc gagaatcggg tgtggaagac ctcggccagc gggattacag gc
#gagcccrt 108900
tagatcctga ccgtcctcgc atacgtagtc gtcttgtgtt agctcttcgc ca
#acatcttc 108960
cgttctgggt tctggttgaa gtcccgatac ggagggaatt gaaacgatct ca
#tgttcccg 109020
tcccaccatg accccgttct ctccaaatag tagatcgtca ggctgactcg ag
#gtgaccac 109080
ccgggccctg tgttcggcgg ccgcggcggc cgcgtccaac aggtccatta ac
#tccaaagt 109140
atcaggcgac cccgcgcgtt ggggtgtaga gcgctgcatc ggcggcgtat cc
#atcgcrct 109200
ggggtgaatt tagacgtacc cgagttttcc aaacgctctc gcagccttca aa
#ggattgcg 109260
rttgcggttg gtgagggagt tccaacagta cttaaaacgt gttgtgcccc cc
#cctcgacc 109320
gcatatttcc tccccgtgtc gtcaccgtgt aaatattctt aatgataaga cg
#atgtagtg 109380
attggacgag actcgaggcg ggaagttcat ggaccatagt atgcgtttaa gg
#agagaccg 109440
ctggttggcg atgtacgccc ggtgtctatt tccgcatacc ttacaacatc at
#aacaaggg 109500
ataccagaca tgtgaatttc atttacatat gtttaaataa caaccaatca tc
#gtgtgtct 109560
acagacgata tataatatac ataaacacaa ttggggttgt ctcacatgca aa
#acatctta 109620
tataacacgg gttgtttcca cccatccggc atctagttaa tcaaatgcac gt
#cgacggtg 109680
tgtttgggtc cctctccgtc gtcattacgt tcgctcaatc aacaagcgta ta
#caccacca 109740
cccctcccaa cgattatcat gtcaggcggc acgaagcccg cgataaccca ta
#aaatacac 109800
acggggttgt ggtgttcacg taaccccccg ccgatgggga gggggcgcgg ta
#ccccgccg 109860
atggggaggg ggcgcggtac cccgccgatg gggagggggc gcggtacccc gc
#cgatgggg 109920
agggggcgcg gtaccccgcc gatggggagg gggcgcggta ccccgccgat gg
#ggaggggg 109980
cgcggtaccc cgccgatggg gagggggcgc ggtaccccgc cgatggggag gg
#ggcgcggt 110040
accccgccga tggggagggg gcgcggtacc ccgccgatgt ttataaccat aa
#ttctctaa 110100
accgttgtag aaaatcacaa aaaaatttat tcaaaaacaa gtcgaagaac tt
#catatctg 110160
aggcatgtaa acccattcgc acttcctggg gtggaatggg gtggggtggg gg
#ggtgaaaa 110220
aggggggggt taaattgggc gtccgcatgt ctgtggtgta cgccaatcgg at
#acactctt 110280
ttaatctgca ttcgcacttc ccgttttttc actgtatggg ttttcatgtt tt
#ggcatgtg 110340
tccaaccacc gttcgcactt tctttctata tatatatata tatagagaga ga
#gagagaga 110400
gagggagaga gtttcttgtt cgcgcgtgtt cccgcgatgt cgcggtttta tg
#gggtgtgg 110460
gcgggctttt cacagaatat atatattcca aatggagcgg caggcttttt aa
#aatcgatt 110520
tgacgtgata aaaaaaaaca cacgggcccc cccttttttt ggtgttataa ag
#gcaaccca 110580
atcgaaggtc tcccgccccg gaatccccca ttgccatttt acccaagtag cc
#ttattcat 110640
agatgtaaac gtttgggtgt gtgttttgtt gtgcagggtt cgtccgattc at
#aacgcgac 110700
agcgtcgagt cggttttaag ggaaaaggtt actacggccc caaggacatg tt
#ttgcacct 110760
caccggctac gcggggcgac tcgtccgagt caaaacccgg ggcatcggtt ga
#tgttaacg 110820
gaaagatgga atatggatct gcaccaggac ccctgaacgg ccgggatacg tc
#gcggggcc 110880
ccggcgcgtt ttgtactccg ggttgggaga tccacccggc caggctcgtt ga
#ggacatca 110940
accgtgtttt tttatgtatt gcacagtcgt cgggacgcgt cacgcgagat tc
#acgaagat 111000
tgcggcgcat atgcctcgac ttttatctaa tgggtcgcac cagacagcgt cc
#cacgttag 111060
cgtgctggga ggaattgtta cagcttcaac ccacccagac gcagtgctta cg
#cgctactt 111120
taatggaagt gtcccatcga ccccctcggg gggaagacgg gttcattgag gc
#gccgaatg 111180
ttcctttgca taggagcgca ctggaatgtg acgtatctga tgatggtggt ga
#agacgata 111240
gcgacgatga tgggtctacg ccatcggatg taattgaatt tcgggattcc ga
#cgcggaat 111300
catcggacgg ggaagacttt atagtggaag aagaatcaga ggagagcacc ga
#ttcttgtg 111360
aaccagacgg ggtacccggc gattgttatc gagacgggga tgggtgcaac ac
#cccgtccc 111420
caaagagacc ccagcgtgcc atcgagcgat acgcgggtgc agaaaccgcg ga
#atatacgg 111480
ccgcgaaagc gctcaccgcg ttgggcgagg ggggtgtaga ttggaagcga cg
#tcgacacg 111540
aagccccgcg ccggcatgat ataccgcccc cccatggcgt gtagtcttta ta
#aataaata 111600
caatggtttg gctcgtgtct ttttttgatg tctgtctgtg ggggagtggg gt
#gttgtgga 111660
tattagaggg tagagggtgc tggtttgaac gtctccatta acccacgggg tc
#cccacacg 111720
ggccgtgtgg tatgaatctc tgcggatccc gcggtgagca cccgggcggt ga
#atatgccg 111780
gactttactg cacacgacac gatacccccg cgcaccrggc tctcatgaac ga
#cgccgaac 111840
ggtacttcgc cgccgcgcta tgcgccatat ctaccgaggc ctacgaggct tt
#tatacaca 111900
gcccctccga gagaccgtgc gcgagtttgt gggggagggc aaaggacgcc tt
#cggacgga 111960
tgtgcgggga gctcgcagcg gatagacaac gtccaccctc ggttccgccg at
#ccgcagag 112020
cggtgttatc gttattacgc gagcaatgca tgccggatcc acaatcgcat ct
#ggagctca 112080
gcgagcggct gatattgatg gcatattggt gctgtttggg acacgccgga ct
#tccgacta 112140
ttggattgtc gcccgataat aaatgcatcc gcgccgaatt atatgaccgc cc
#cgggggaa 112200
tttgtcacag gctttttgac gcgtacctgg gctgcgggtc ccttggagtc cc
#aagaaccc 112260
acgagagatc ctgacacccc atccctttat atagaaaaaa aaataaattt aa
#aacataca 112320
ccggataaaa gcgtactgtt ttttatttaa atttacacgc tcgacgttgc cc
#cggttcgg 112380
tgatcaccgg gtcttatcta tatacaccgt gtaactcgaa cccccgtgac tc
#cctccaat 112440
cgcgttacca aactcttctt ccgtatccgt agattccgag tcctcgaaat cg
#tccactta 112500
tccaacaaat tgtgacgtta tatatcccaa ggcaaaggcc gctcccgtca ta
#gcaaatac 112560
aaagacaatt attagcgtaa tataacagaa ttttttacga tgatatattt ta
#tgttgata 112620
ttttccaatt cgacgcaaaa attcatctgc cgtttcattt tcgctatcac ta
#taataaca 112680
cttttcagcc gaacggctcg gttgtatggc tgttatcgtt gtattatttg gt
#tgcgctcg 112740
cggggttacc accgcttcca tcagtaaggc cacggcctca ccctccatgg tg
#ttttgtcc 112800
ggccatagaa atccagattg taaggccagc aggctagttt aaaagtgttt aa
#taccacac 112860
cttttgatat ttatatacat gcaagattct agattattca tcaataggtc gt
#ttaaagcg 112920
cgttttcata aacgttgtca gctataccga cattctcaca aagaggtaaa gt
#taccttac 112980
gttattatta aataaaacat gtagacatta ttaataatcc taggaacaat ca
#aatccata 113040
tttgtaagtt atgtttaacc cctccccttt ttgtcattat ctccgccctc tt
#ataatcgg 113100
atcactttat aagtgtgtcg gtgagtatat tttgtacagt tgttggacaa ca
#ggtttttg 113160
gttcattaac actatcaaca taagtcgggg tatacaagta taatgaacga cg
#ttgatgca 113220
acagacacct ttgttggaca aggaaagttc cgtggcgcca tctcaacatc ac
#cgtcacat 113280
attatgcaaa catgtgggtt tatacaacag atgtttccag ttgaaatgtc gc
#ccggcata 113340
gaatctgagg atgatcccaa ttatgacgtt aacatggata tacagtcttt ta
#atatattt 113400
gatggtgtac acgaaactga agccgaagcc tctgtggcat tgtgcgcaga ag
#cacgcgtt 113460
ggaattaata aagcgggatt tgtaatatta aaaacgttta caccaggggc gg
#aaggtttt 113520
gcgtttgcgt gtatggacag taaaacatgt gaacatgtgg tcattaaagc gg
#gtcaacgt 113580
caaggaacgg ccaccgaggc aaccgtgtta agagcgttaa cccacccatc cg
#ttgtacag 113640
cttaaaggaa cgtttacgta taacaaaatg acatgtctta tattaccacg tt
#accgaaca 113700
gatttatact gctatctagc tgcaaagcgc aacctcccca tatgtgacat tt
#tagcaatt 113760
cagcgatctg tattacgcgc gttacagtat cttcataata acagtattat tc
#accgtgat 113820
ataaaatctg aaaatatatt tattaaccac ccaggtgatg tttgtgtggg ag
#actttgga 113880
gcagcgtgtt tccccgtgga tattaatgcc aacaggtatt atggctgggc tg
#gaacaatc 113940
gccacaaact ctcctgagtt attggctaga gatccatatg gacctgccgt gg
#acatatgg 114000
agtgccggga ttgtattatt tgaaatggct acaggacaga actcgttatt tg
#aacgagac 114060
ggtttagatg gcaattgtga cagtgagcgt caaattaaac ttattatacg ac
#gatctgga 114120
actcatccca atgaatttcc cattaaccct acatcaaatc ttcgtcgaca at
#acattggt 114180
ttggcaaaac ggtcttctcg aaaacccgga tccaggccat tgtggacaaa tc
#tatatgag 114240
ttgccaattg atttggagta tttgatatgt aagatgttat cgtttgacgc ac
#gtcatcga 114300
ccatcggcag aggtgttgct taaccactct gttttccaaa ctcttcccga tc
#catatcca 114360
aatccaatgg aagttggaga ttaaaattca ttaagcctgt taataaaata tt
#gtataaat 114420
tgtgtttata acgtataacc cgttaaggca aatagggtac aaacgcgcaa tg
#ttttgaaa 114480
tactaatata aataacataa ccaatagaaa cttaatacag agtcacgccc ca
#ttacaaca 114540
aggataaaac acgggatcat tttcttaaca ttgtagtagc gctgaaaagc gt
#cccctccc 114600
ccggctcaca gagctgctct tcggtgtagt tgggtatact ggtgcgcctc at
#ttaatcgc 114660
gatgttttta atccaatgtt tgatatcggc cgttatattt tacatacaag tg
#accaacgc 114720
tttgatcttc aagggcgacc acgtgagctt gcaagttaac agcagtctca cg
#tctatcct 114780
tattcccatg caaaatgata attatacaga gataaaagga cagcttgtct tt
#attggaga 114840
gcaactacct accgggacaa actatagcgg aacactggaa ctgttatacg cg
#gatacggt 114900
ggcgttttgt ttccggtcag tacaagtaat aagatacgac ggatgtcccc gg
#attagaac 114960
gagcgctttt atttcgtgta ggtacaaaca ttcgtggcat tatggtaact ca
#acggatcg 115020
gatatcaaca gagccggatg ctggtgtaat gttgaaaatt accaaaccgg ga
#ataaatga 115080
tgctggtgtg tatgtacttc ttgttcggtt agaccatagc agatccaccg at
#ggtttcat 115140
tcttggtgta aatgtatata cagcgggctc gcatcacaac attcacgggg tt
#atctacac 115200
ttctccatct ctacagaatg gatattctac aagagccctt tttcaacaag ct
#cgtttgtg 115260
tgatttaccc gcgacaccca aagggtccgg tacctccctg tttcaacata tg
#cttgatct 115320
tcgtgccggt aaatcgttag aggataaccc ttggttacat gaggacgttg tt
#acgacaga 115380
aactaagtcc gttgttaagg aggggataga aaatcacgta tatccaacgg at
#atgtccac 115440
gttacccgaa aagtccctta atgatcctcc agaaaatcta cttataatta tt
#cctatagt 115500
agcgtctgtc atgatcctca ccgccatggt tattgttatt gtaataagcg tt
#aagcgacg 115560
tagaattaaa aaacatccaa tttatcgccc aaatacaaaa acaagaaggg gc
#atacaaaa 115620
tgcgacacca gaatccgatg tgatgttgga ggccgccatt gcacaactag ca
#acgattcg 115680
cgaagaatcc cccccacatt ccgttgtaaa cccgtttgtt aaatagaact aa
#ttatcccg 115740
gattttatat taaataaact atatgcgttt tatttagcgt tttgattacg cg
#ttgtgata 115800
tgaggggaag gattaagaat ctcctaacta taagttaaca cgcccacatt tg
#ggcgggga 115860
tgttttatga agccttaaag gccgagctgg tatacacgag agcagtccat gg
#ttttagac 115920
ctcgggcgaa ttgcgtggtt ttaagtgact atattccgag ggtcgcctgt aa
#tatgggga 115980
cagttaataa acctgtggtg ggggtattga tggggttcgg aattatcacg gg
#aacgttgc 116040
gtataacgaa tccggtcaga gcatccgtct tgcgatacga tgattttcac at
#cgatgaag 116100
acaaactgga tacaaactcc gtatatgagc cttactacca ttcagatcat gc
#ggagtctt 116160
catgggtaaa tcggggagag tcttcgcgaa aagcgtacga tcataactca cc
#ttatatat 116220
ggccacgtaa tgattatgat ggatttttag agaacgcaca cgaacaccat gg
#ggtgtata 116280
atcagggccg tggtatcgat agcggggaac ggttaatgca acccacacaa at
#gtctgcac 116340
aggaggatct tggggacgat acgggcatcc acgttatccc tacgttaaac gg
#cgatgaca 116400
gacataaaat tgtaaatgtg gaccaacgtc aatacggtga cgtgtttaaa gg
#agatctta 116460
atccaaaacc ccaaggccaa agactcattg aggtgtcagt ggaagaaaat ca
#cccgttta 116520
ctttacgcgc accgattcag cggatttatg gagtccggta caccgagact tg
#gagctttt 116580
tgccgtcatt aacctgtacg ggagacgcag cgcccgccat ccagcatata tg
#tttaaaac 116640
atacaacatg ctttcaagac gtggtggtgg atgtggattg cgcggaaaat ac
#taaagagg 116700
atcagttggc cgaaatcagt taccgttttc aaggtaagaa ggaagcggac ca
#accgtgga 116760
ttgttgtaaa cacgagcaca ctgtttgatg aactcgaatt agaccccccc ga
#gattgaac 116820
cgggtgtctt gaaagtactt cggacagaaa aacaatactt gggtgtgtac at
#ttggaaca 116880
tgcgcggctc cgatggtacg tctacctacg ccacgttttt ggtcacctgg aa
#aggggatg 116940
aaaaaacaag aaaccctacg cccgcagtaa ctcctcaacc aagaggggct ga
#gtttcata 117000
tgtggaatta ccactcgcat gtattttcag ttggtgatac gtttagcttg gc
#aatgcatc 117060
ttcagtataa gatacatgaa gcgccatttg atttgctgtt agagtggttg ta
#tgtcccca 117120
tcgatcctac atgtcaacca atgcggttat attctacgtg tttgtatcat cc
#caacgcac 117180
cccaatgcct ctctcatatg aattccggtt gtacatttac ctcgccacat tt
#agcccagc 117240
gtgttgcaag cacagtgtat caaaattgtg aacatgcaga taactacacc gc
#atattgtc 117300
tgggaatatc tcatatggag cctagctttg gtctaatctt acacgacggg gg
#caccacgt 117360
taaagtttgt agatacaccc gagagtttgt cgggattata cgtttttgtg gt
#gtatttta 117420
acgggcatgt tgaagccgta gcatacactg ttgtatccac agtagatcat tt
#tgtaaacg 117480
caattgaaga gcgtggattt ccgccaacgg ccggtcagcc accggcgact ac
#taaaccca 117540
aggaaattac ccccgtaaac cccggaacgt caccacttct acgatatgcc gc
#atggaccg 117600
gagggcttgc agcagtagta cttttatgtc tcgtaatatt tttaatctgt ac
#ggctaaac 117660
gaatgagggt taaagcctat agggtagaca agtccccgta taaccaaagc at
#gtattacg 117720
ctggccttcc agtggacgat ttcgaggact cggaatctac ggatacggaa ga
#agagtttg 117780
gtaacgcgat tggagggagt cacgggggtt cgagttacac ggtgtatata ga
#taagaccc 117840
ggtgatcacc gaaccggggc aacgtcgagc gtgtaaattt aaataaaaaa ca
#gtacgctt 117900
ttatccggtg tatgttttaa atttattttt ttttctatat aaagggatgg gg
#tgtcagga 117960
tctctcgtgg gttcttggga ctccaaggga cccgcagccc aggtacgcgt ca
#aaaagcct 118020
gtgacaaatt cccccggggc ggtcatataa ttcggcgcgg atgcatttat ta
#tcgggcga 118080
caatccaata gtcggaagtc cggcgtgtcc caaacagcac caatatgcca tc
#aatatcag 118140
ccgctcgctg agctccagat gcgattgtgg atccggcatg cattgctcgc gt
#aataacga 118200
taacaccgct ctgcggatcg gcggaaccga gggtggacgt tgtctatccg ct
#gcgagctc 118260
cccgcacatc cgtccgaagg cgtcctttgc cctcccccac aaactcgcgc ac
#ggtctctc 118320
ggaggggctg tgtataaaag cctcgtaggc ctcggtagat atggcgcata gc
#gcggcggc 118380
gaagtaccgt tcggcgtcgt tcatgagagc ccggtgcgcg ggggtatcgt gt
#cgtgtgca 118440
gtaaagtccg gcatattcac cgcccgggtg ctcaccgcgg gatccgcaga ga
#ttcatacc 118500
acacggcccg tgtggggacc ccgtgggtta atggagacgt tcaaaccagc ac
#cctctacc 118560
ctctaatatc cacaacaccc cactccccca cagacagaca tcaaaaaaag ac
#acgagcca 118620
aaccattgta tttatttata aagactacac gccatggggg ggcggtatat ca
#tgccggcg 118680
cggggcttcg tgtcgacgtc gcttccaatc tacacccccc tcgcccaacg cg
#gtgagcgc 118740
tttcgcggcc gtatattccg cggtttctgc acccgcgtat cgctcgatgg ca
#cgctgggg 118800
tctctttggg gacggggtgt tgcacccatc cccgtctcga taacaatcgc cg
#ggtacccc 118860
gtctggttca caagaatcgg tgctctcctc tgattcttct tccactataa ag
#tcttcccc 118920
gtccgatgat tccgcgtcgg aatcccgaaa ttcaattaca tccgatggcg ta
#gacccatc 118980
atcgtcgcta tcgtcttcac caccatcatc agatacgtca cattccagtg cg
#ctcctatg 119040
caaaggaaca ttcggcgcct caatgaaccc gtcttccccc cgagggggtc ga
#tgggacac 119100
ttccattaaa gtagcgcgta agcactgcgt ctgggtgggt tgaagctgta ac
#aattcctc 119160
ccagcacgct aacgtgggac gctgtctggt gcgacccatt agataaaagt cg
#aggcatat 119220
gcgccgcaat cttcgtgaat ctcgcgtgac gcgtcccgac gactgtgcaa ta
#cataaaaa 119280
aacacggttg atgtcctcaa cgagcctggc cgggtggatc tcccaacccg ga
#gtacaaaa 119340
cgcgccgggg ccccgcgacg tatcccggcc gttcaggggt cctggtgcag at
#ccatattc 119400
catctttccg ttaacatcaa ccgatgcccc gggttttgac tcggacgagt cg
#ccccgcgt 119460
agccggtgag gtgcaaaaca tgtccttggg gccgtagtaa ccttttccct ta
#aaaccgac 119520
tcgacgctgt cgcgttatga atcggacgaa ccctgcacaa caaaacacac ac
#ccaaacgt 119580
ttacatctat gaataaggct acttgggtaa aatggcaatg ggggattccg gg
#gcgggaga 119640
ccttcgattg ggttgccttt ataacaccaa aaaaaggggg ggcccgtgtg tt
#ttttttta 119700
tcacgtcaaa tcgattttaa aaagcctgcc gctccatttg gaatatatat at
#tctgtgaa 119760
aagcccgccc acaccccata aaaccgcgac atcgcgggaa cacgcgcgaa ca
#agaaactc 119820
tctccctctc tctctctctc tctctatata tatatatata tagaaagaaa gt
#gcgaacgg 119880
tggttggaca catgccaaaa catgaaaacc catacagtga aaaaacggga ag
#tgcgaatg 119940
cagattaaaa gagtgtatcc gattggcgta caccacagac atgcggacgc cc
#aatttaac 120000
cccccccttt ttcacccccc caccccaccc cattccaccc caggaagtgc ga
#atgggttt 120060
acatgcctca gatatgaagt tcttcgactt gtttttgaat aaattttttt gt
#gattttct 120120
acaacggttt agagaattat ggttataaac atcggcgggg taccgcgccc cc
#tccccatc 120180
ggcggggtac cgcgccccct ccccatcggc ggggtaccgc gccccctccc ca
#tcggcggg 120240
gtaccgcgcc ccctccccat cggcggggta ccgcgccccc tccccatcgg cg
#gggtaccg 120300
cgccccctcc ccatcggcgg ggtaccgcgc cccctcccca tcggcggggt ac
#cgcgcccc 120360
ctccccatcg gcggggtacc gcgccccctc cccatcggcg gggggttacg tg
#aacaccac 120420
aaccccgtgt gtattttatg ggttatcgcg ggcttcgtgc cgcctgacat ga
#taatcgtt 120480
gggaggggtg gtggtgtata cgcttgttga ttgagcgaac gtaatgacga cg
#gagaggga 120540
cccaaacaca ccgtcgacgt gcatttgatt aactagatgc cggatgggtg ga
#aacaaccc 120600
gtgttatata agatgttttg catgtgagac aaccccaatt gtgtttatgt at
#attatata 120660
tcgtctgtag acacacgatg attggttgtt atttaaacat atgtaaatga aa
#ttcacatg 120720
tctggtatcc cttgttatga tgttgtaagg tatgcggaaa tagacaccgg gc
#gtacatcg 120780
ccaaccagcg gtctctcctt aaacgcatac tatggtccat gaacttcccg cc
#tcgagtct 120840
cgtccaatca ctacatcgtc ttatcattaa gaatatttac acggtgacga ca
#cggggagg 120900
aaatatgcgg tcgagggggg ggcacaacac gttttaagta ctgttggaac tc
#cctcacca 120960
accgcaaycg caatcctttg aaggctgcga gagcgtttgg aaaactcggg ta
#cgtctaaa 121020
ttcaccccag ygcgatggat acgccgccga tgcagcgctc tacaccccaa cg
#cgcggggt 121080
cgcctgatac tttggagtta atggacctgt tggacgcggc cgccgcggcc gc
#cgaacaca 121140
gggcccgggt ggtcacctcg agtcagcctg acgatctact atttggagag aa
#cggggtca 121200
tggtgggacg ggaacatgag atcgtttcaa ttccctccgt atcgggactt ca
#accagaac 121260
ccagaacgga agatgttggc gaagagctaa cacaagacga ctacgtatgc ga
#ggacggtc 121320
aggatctaay gggctcgcct gtaatcccgc tggccgaggt cttccacacc cg
#attctcgg 121380
aggccggcgc gcgagaacca acaggagccg atcgctccct cgagacagtc tc
#tctcggaa 121440
cgaagcttgc taggtctcca aaaccaccga tgaacgatgg ggaaacgggc ag
#aggtacga 121500
cccctccgtt cccgcaggcc ttctcccctg tatcccccgc gtctcctgtt gg
#agacgccg 121560
ccgggaacga tcaacgggaa gaccagcggt ctataccccg acaaacgacg ag
#aggaaatt 121620
caccaggttt gccgtcggtg gtccatcgag acagacaaac tcagtccatc tc
#gggtaaaa 121680
agccgggcga tgagcaagcg ggtcatgcgc atgcatcggg ggacggagta gt
#tctccaga 121740
aaactcaacg gcccgctcag ggaaagagcc cgaagaaaaa gactttgaag gt
#taaggtcc 121800
cactcccggc gcggaaaccc ggtggacctg tacccggccc ggttgagcaa tt
#gtaccacg 121860
tcctttcgga cagcgttccc gctaaggggg caaaggcgga cctgccgttt ga
#gaccgatg 121920
atacccgccc aaggaaacat gatgcccggg gtataacacc tcgcgtccct gg
#acgttcgt 121980
cggggggcaa acctagagcg tttttggccc tgccgggaag atcccacgca cc
#agacccga 122040
ttgaggatga cagcccggtg gagaaaaagc caaagagtcg tgagtttgtt tc
#gtcttcat 122100
cctcttcctc gtcgtgggga tcgtcatcgg aggatgaaga cgatgaaccc cg
#gcgcgttt 122160
cggtgggaag tgaaactaca ggcagcaggt ccggacgcga acacgcccct tc
#cccgtcaa 122220
attcggatga ttcggactca aatgatggtg ggtcgacgaa acaaaatatc ca
#accgggat 122280
atcgatccat cagcggtccc gatccgagga ttcgtaagac caaacgtctt gc
#gggggaac 122340
cggggcgcca gagacagaaa tcattttccc tgccgcgatc cagaaccccg at
#aattcccc 122400
cggtgtcggg gccgctcatg atgcccgacg gaagcccttg gcccggatcg gc
#gcccctcc 122460
catccaacag ggtgcggttt ggaccgtccg gggagaccag agagggtcac tg
#ggaggatg 122520
aggctgtgag agcggcgcgg gctcgttacg aggcctcaac tgaacccgyg cc
#gctttacg 122580
tgccggagtt gggagatccg gctagacagt accgcgcgct gattaacctg at
#ctactgtc 122640
cagacagaga ccctatagca tggctccaga accccaagct gaccggtgtc aa
#ctcggccc 122700
tgaaccagtt ctaccaaaag ctgttgccac cgggacgggc gggtaccgcc gt
#tacgggga 122760
gcgtagcgtc tcccgttccg catgtaggcg aagccatggc cacgggggag gc
#cctctggg 122820
ctctccccca cgcggccgcg gccgtggcta tgagccgtcg gtacgaccgg gc
#ccaaaaac 122880
actttatcct acagagtctc cgcagagcct ttgccggcat ggcatacccc ga
#ggcaacgg 122940
gctccagtcc ggcggcgcgg atctcccgcg gtcacccttc tccaacaacc cc
#ggccacac 123000
agactcccga ccctcagccg tcggccgccg cgcgctctct ttctgtgtgt cc
#accggatg 123060
atcgtttacg aactccgcgc aagcgcaagt cccagccagt cgagagcaga ag
#cctcctcg 123120
acaagattag ggagacaccc gtcgcggacg cccgggttgc agacgatcat gt
#ggtttcca 123180
aggccaagag gcgggtatcc gagcccgtga ccatcacctc gggccctgtg gt
#ggatcccc 123240
ccgccgtaat aacgatgcca cttgacggac cggccccaaa cgggggattt cg
#gcgtattc 123300
cccggggggc cctgcatacc ccggtcccgt cggaccaggc tcgcaaggcg ta
#ctgtaccc 123360
ccgaaaccat cgcccgtctg gtcgacgacc cattgtttcc cacggcctgg cg
#ccctgcgc 123420
taagctttga tcccggcgcc ttggcggaaa tcgccgctcg gcgtccgggc gg
#aggagacc 123480
gacggtttgg tccacccagc ggagtggagg cgctgcgacg gaggtgcgcc tg
#gatgcggc 123540
agatcccaga cccggaggat gtgaggcttc tgatcatcta cgatccgttg cc
#cggagagg 123600
acatcaacgg ccccctcgag agcaccctcg cgacagatcc gggaccgtca tg
#gagtccat 123660
cccgaggggg actgtctgtg gtcctggcag ccctgagtaa ccggttgtgc ct
#gccgagca 123720
ctcatgcctg ggccgggaac tggaccggcc cgccggacgt gtccgctttg aa
#cgcccggg 123780
gcgttttatt actgtcgacc cgagacctgg cctttgccgg ggccgtcgag ta
#tctaggct 123840
cgcggttggc ctctgcccgg cgccggttgc tggtgttgga cgcggtggcc ct
#cgagaggt 123900
ggcccgggga tggacccgct ttgtctcagt atcacgtgta cgtccgggcc cc
#ggcgcgac 123960
cggacgccca ggccgtcgtc cgatggccag actcggcggt cacagaagga ct
#cgcccggg 124020
ccgtgtttgc atcgtcgcgc acctttgggc cagcgagttt tgctcgtatc ga
#gactgcgt 124080
ttgccaacct gtacccgggc gaacaacccc tgtgtttgtg ccgcggtggg aa
#cgtcgcat 124140
acaccgtgtg tacccgcgcg ggccccaaga cccgcgtccc cctgtcgccc cg
#tgaatacc 124200
ggcagtacgt gctgccgggt tttgacggtt gcaaggacct cgcgcgacag tc
#tcggggtc 124260
tggggctcgg ggcagccgac tttgtggacg aggcggcaca tagccaccgc gc
#agcaaacc 124320
gatggggcct gggtgccgcg cttcgacccg tcttccttcc cgagggacgg ag
#accggggg 124380
ccgccgggcc ggaggccggc gacgtaccca cctgggcgag ggtgttttgc cg
#ccacgccc 124440
tgctggaacc cgaccctgcc gcggaaccac tcgtgcttcc acccgtggcc gg
#tcggtcgg 124500
tggcgctgta tgcgtcggcg gacgaggctc ggaatgccct ccccccgatt cc
#cagagtaa 124560
tgtggccgcc cggttttggg gccgcggaga cggtgttgga ggggagcgac gg
#aacacggt 124620
tcgcgttcgg acaccacggg ggctcggaac ggccggcaga aacccaggcg gg
#gcgacagc 124680
ggcgcaccgc agacgacaga gaacacgctt tggagccgga cgattgggag gt
#ggggtgtg 124740
aagacgcgtg ggacagcgag gaggggggcg gggacgacgg ggacgcaccg gg
#gtcatcct 124800
ttggggtgag cgtcgtgtcg gtggccccgg gtgtgctgcg agaccgccgg gt
#gggctygc 124860
gcccggcggt caaggtggag ctgttgtcct cgtcctcgtc ctccgaggac ga
#ggacgatg 124920
tgtggggagg gcgcgggggg aggagccccc cgcagagtcg ggggtgacgg ag
#tcccctcc 124980
ttttctcgtg agcgccacyg gcgcgcggac tgtttgttgt ttgttaataa aa
#gcggaacg 125040
gtttttatga aaaaagtgtc tgtctgtctg tgcgggcggg cgacgggcgg gc
#tggtcgga 125100
ccccccccga aaataacccc ccccggtttc tgggcgcccg gcggaccccg gg
#ggggg    125157
<210> SEQ ID NO 3
<211> LENGTH: 25
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: PCR Primer used for de
#tecting a mutation of the
560th nucleotide of a varicella v
#accine virus
<400> SEQUENCE: 3
tcgtttactg ctcggatggc gaccg
#
#               25
<210> SEQ ID NO 4
<211> LENGTH: 25
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: PCR Primer used for de
#tecting a mutation of the
560th nucleotide of a varicella v
#accine virus
<400> SEQUENCE: 4
gtgtttatgt atcagcatac agagc
#
#               25
<210> SEQ ID NO 5
<211> LENGTH: 24
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: PCR Primer used for de
#tecting a mutation of the
5745th nucleotide of a varicella
#vaccine virus
<400> SEQUENCE: 5
ttgtatgcat gcgattgcta tcgc
#
#                24
<210> SEQ ID NO 6
<211> LENGTH: 25
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: PCR Primer used for de
#tecting a mutation of the
5745th nucleotide of a varicella
#vaccine virus
<400> SEQUENCE: 6
ggtcttccac tttaaagggg tttgc
#
#               25
<210> SEQ ID NO 7
<211> LENGTH: 25
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: PCR Primer used for de
#tecting a mutation of the
26125th nucleotide of a varicella
#vaccine virus
<400> SEQUENCE: 7
gaatcattag tatatatttt tctgc
#
#               25
<210> SEQ ID NO 8
<211> LENGTH: 25
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: PCR Primer used for de
#tecting a mutation of the
26125th nucleotide of a varicella
#vaccine virus
<400> SEQUENCE: 8
tgttcagagg ggatgaatcg ttgcg
#
#               25
<210> SEQ ID NO 9
<211> LENGTH: 25
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: PCR Primer used for de
#tecting a mutation of the
94167th nucleotide of a varicella
#vaccine virus
<400> SEQUENCE: 9
cgatcacgtc gctcacatcc aaccc
#
#               25
<210> SEQ ID NO 10
<211> LENGTH: 25
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: PCR Primer used for de
#tecting a mutation of the
94167th nucleotide of a varicella
#vaccine virus
<400> SEQUENCE: 10
atggcagaag aaacacgtat tgccg
#
#               25
<210> SEQ ID NO 11
<211> LENGTH: 25
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: PCR Primer used for de
#tecting a mutation of the
105356th, 124353rd, and 124541st
#nucleotide of a varicella
vaccine virus
<400> SEQUENCE: 11
gaggacaaca gctccacctt gaccg
#
#               25
<210> SEQ ID NO 12
<211> LENGTH: 25
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: PCR Primer used for de
#tecting a mutation of the
105356th, 124353rd, and 124541st
#nucleotide of a varicella
vaccine virus
<400> SEQUENCE: 12
gagtaatgtg gccgcccggt tttgg
#
#               25
<210> SEQ ID NO 13
<211> LENGTH: 25
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: PCR Primer used for de
#tecting a mutation of the
105705th, 106262nd, 123635th, and 12
#4192nd  nucleotide of a
varicella vaccine virus
<400> SEQUENCE: 13
ccaaaaccgg gcggccacat tactc
#
#               25
<210> SEQ ID NO 14
<211> LENGTH: 25
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: PCR Primer used for de
#tecting a mutation of the
105705th, 106262nd, 123635th, and 12
#4192nd  nucleotide of a
varicella vaccine virus
<400> SEQUENCE: 14
attactgtcg acccgagacc tggcc
#
#               25
<210> SEQ ID NO 15
<211> LENGTH: 18
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: PCR Primer used for de
#tecting a mutation of the
107136th, 107252nd, 122645th, and 12
#2761st  nucleotide of a
varicella vaccine virus
<400> SEQUENCE: 15
gatcaaagct tagcgcag
#
#
#  18
<210> SEQ ID NO 16
<211> LENGTH: 18
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: PCR Primer used for de
#tecting a mutation of the
107136th, 107252nd, 122645th, and 12
#2761st  nucleotide of a
varicella vaccine virus
<400> SEQUENCE: 16
cctatagcat ggctccag
#
#
#  18
<210> SEQ ID NO 17
<211> LENGTH: 25
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: PCR Primer used for de
#tecting a mutation of the
108111st and 121786th  nucleotide
#of a varicella vaccine virus
<400> SEQUENCE: 17
aagggcttcc gtcgggcatc atgag
#
#               25
<210> SEQ ID NO 18
<211> LENGTH: 25
<212> TYPE: DNA
<213> ORGANISM: Artificial Sequence
<220> FEATURE:
<223> OTHER INFORMATION: PCR Primer used for de
#tecting a mutation of the
108111st and 121786th  nucleotide
#of a varicella vaccine virus
<400> SEQUENCE: 18
tcgggtaaaa agccgggcga tgagc
#
#               25
<210> SEQ ID NO 19
<211> LENGTH: 18
<212> TYPE: DNA
<213> ORGANISM: Varicella virus
<400> SEQUENCE: 19
ggacgcgatc gacgacga
#
#
#  18
<210> SEQ ID NO 20
<211> LENGTH: 18
<212> TYPE: DNA
<213> ORGANISM: Varicella virus
<400> SEQUENCE: 20
ggacgcgatt gacgacga
#
#
#  18
<210> SEQ ID NO 21
<211> LENGTH: 15
<212> TYPE: DNA
<213> ORGANISM: Varicella virus
<400> SEQUENCE: 21
gggagaggcg gagga
#
#
#    15
<210> SEQ ID NO 22
<211> LENGTH: 15
<212> TYPE: DNA
<213> ORGANISM: Varicella virus
<400> SEQUENCE: 22
ggacgcggcg gagga
#
#
#    15
<210> SEQ ID NO 23
<211> LENGTH: 261
<212> TYPE: DNA
<213> ORGANISM: Varicella virus
<220> FEATURE:
<221> NAME/KEY: misc_feature
<222> LOCATION: (1)..(261)
<223> OTHER INFORMATION: Attenuated Oka strain
<400> SEQUENCE: 23
ggacgcgatc gacgacgagg gagaggcgga ggagggagag gcggaggagg ac
#gcgatcga     60
cgacgaggga gaggcggagg agggagaggc ggaggaggac gcgattgacg ac
#gagggaga    120
ggcggaggag ggagaggcgg aggaggacgc ggcggaggag gacgcgatcg ac
#gacgaggg    180
agaggcggag gaggacgcga tcgacgacga gggagaggcg gaggaggacg cg
#atcgacga    240
cgagggagag gcggaggagg a
#
#                 261
<210> SEQ ID NO 24
<211> LENGTH: 27
<212> TYPE: DNA
<213> ORGANISM: Varicella virus
<400> SEQUENCE: 24
ccccgccgat ggggaggggg cgcggta
#
#             27
<210> SEQ ID NO 25
<211> LENGTH: 11
<212> TYPE: DNA
<213> ORGANISM: Varicella virus
<400> SEQUENCE: 25
ccccgccgat g
#
#
#       11
<210> SEQ ID NO 26
<211> LENGTH: 335
<212> TYPE: DNA
<213> ORGANISM: Varicella virus
<220> FEATURE:
<221> NAME/KEY: misc_feature
<222> LOCATION: (1)..(335)
<223> OTHER INFORMATION: Attenuated Oka strain
<400> SEQUENCE: 26
ccccgccgat ggggaggggg cgcggtaccc cgccgatggg gagggggcgc gg
#taccccgc     60
cgatggggag ggggcgcggt accccgccga tggggagggg gcgcggtacc cc
#gccgatgg    120
ggagggggcg cggtaccccg ccgatgggga gggggcgcgg taccccgccg at
#ggggaggg    180
ggcgcggtac cccgccgatg gggagggggc gcggtacccc gccgatgggg ag
#ggggcgcg    240
gtaccccgcc gatggggagg gggcgcggta ccccgccgat ggggaggggg cg
#cggtaccc    300
cgccgatggg gagggggcgc ggtaccccgc cgatg
#
#      335
<210> SEQ ID NO 27
<211> LENGTH: 14
<212> TYPE: DNA
<213> ORGANISM: Varicella virus
<400> SEQUENCE: 27
tatatatata tata
#
#
#     14
<210> SEQ ID NO 28
<211> LENGTH: 265
<212> TYPE: DNA
<213> ORGANISM: Varicella virus
<220> FEATURE:
<221> NAME/KEY: misc_feature
<222> LOCATION: (1)..(265)
<223> OTHER INFORMATION: Dumas strain
<400> SEQUENCE: 28
gtacgccaat cggatacact cttttgatct gcattcgcac ttcccgtttt tt
#cactgtat     60
gggtttcatt gttttggcat gtgtccaacc accgttcgca ctttctttct at
#atatatat    120
atatatatat atatatatat agagaaagag agagagtttc ttgttcgcgc gt
#gttcccgc    180
gatgtcgcgg ttttatgggg tgtgggcggg cttttcacag aatatatata tt
#ccaaatgg    240
agcggcaggc tttttaaaat cgatt
#
#              265
<210> SEQ ID NO 29
<211> LENGTH: 271
<212> TYPE: DNA
<213> ORGANISM: Varicella virus
<220> FEATURE:
<221> NAME/KEY: misc_feature
<222> LOCATION: (1)..(271)
<223> OTHER INFORMATION: Parental Oka strain
<400> SEQUENCE: 29
gtacgccaat cggatacact cttttaatct gcattcgcac ttcccgtttt tt
#cactgtat     60
gggtttcatt gttttggcat gtgtccaacc accgttcgca ctttctttct at
#atatatat    120
atatatatat atagagagag agagagagag agagggagag agtttcttgt tc
#gcgcgtgt    180
tcccgcgatg tcgcggtttt atggggtgtg ggcgggcttt tcacagaata ta
#tatattcc    240
aaatggagcg gcaggctttt taaaatcgat t
#
#         271
<210> SEQ ID NO 30
<211> LENGTH: 263
<212> TYPE: DNA
<213> ORGANISM: Varicella virus
<220> FEATURE:
<221> NAME/KEY: misc_feature
<222> LOCATION: (1)..(263)
<223> OTHER INFORMATION: Attenuated Oka strain
<400> SEQUENCE: 30
gtacgccaat cggatacact cttttaatct gcattcgcac ttcccgtttt tt
#cactgtat     60
gggtttcatt gttttggcat gtgtccaacc accgttcgca ctttctttct at
#atatatat    120
atatatagag agagagagag agagagggag agagtttctt gttcgcgcgt gt
#tcccgcga    180
tgtcgcggtt ttatggggtg tgggcgggct tttcacagaa tatatatatt cc
#aaatggag    240
cggcaggctt tttaaaatcg att
#
#               263
<210> SEQ ID NO 31
<211> LENGTH: 228
<212> TYPE: DNA
<213> ORGANISM: Varicella virus
<220> FEATURE:
<221> NAME/KEY: misc_feature
<222> LOCATION: (1)..(228)
<223> OTHER INFORMATION: Parental Oka strain
<400> SEQUENCE: 31
ggacgcgatc gacgacgagg gagaggcgga ggagggagag gcggaggagg ac
#gcgatcga     60
cgacgaggga gaggcggagg agggagaggc ggaggaggac gcgattgacg ac
#gagggaga    120
ggcggaggag ggagaggcgg aggaggacgc ggcggaggag gacgcgatcg ac
#gacgaggg    180
agaggcggag gaggacgcga tcgacgacga gggagaggcg gaggagga
#               228
<210> SEQ ID NO 32
<211> LENGTH: 306
<212> TYPE: DNA
<213> ORGANISM: Varicella virus
<220> FEATURE:
<221> NAME/KEY: misc_feature
<222> LOCATION: (1)..(306)
<223> OTHER INFORMATION: Dumas strain
<400> SEQUENCE: 32
ggacgcgatc gacgacgagg gagaggcgga ggagggagag gcggaggagg ac
#gcgatcga     60
cgacgaggga gaggcggagg agggagaggc ggaggaggac gcgattgacg ac
#gagggaga    120
ggcggaggag ggagaggcgg aggaggacgc gattgacgac gagggagagg cg
#gaggaggg    180
agaggcggag gagggagagg cggaggaggg agaggcggag gaggacgcga tc
#gacgacga    240
gggagaggcg gaggaggacg cggcggagga ggacgcgatc gacgacgagg ga
#gaggcgga    300
ggagga
#
#
#          306
<210> SEQ ID NO 33
<211> LENGTH: 138
<212> TYPE: DNA
<213> ORGANISM: Varicella virus
<220> FEATURE:
<221> NAME/KEY: misc_feature
<222> LOCATION: (1)..(138)
<223> OTHER INFORMATION: Attenuated Oka strain
<400> SEQUENCE: 33
gcccgtccag cccgtccagc ccgcgcagcc cgtccagccc gtccagcccg cg
#cagcccgt     60
ccagcccgtc cagcccgcgc agcccgtcca gcccgcgcag cccgtccagc cc
#gcgcagcc    120
cgtccagccc gcgcagga
#
#
# 138
<210> SEQ ID NO 34
<211> LENGTH: 93
<212> TYPE: DNA
<213> ORGANISM: Varicella virus
<220> FEATURE:
<221> NAME/KEY: misc_feature
<222> LOCATION: (1)..(93)
<223> OTHER INFORMATION: Attenuated Oka strain
<400> SEQUENCE: 34
gcccgtccag cccgtccagc ccgcgcagcc cgtccagccc gcgcagcccg cg
#cagcccgt     60
ccagcccgcg cagcccgtcc agcccgcgca gga
#
#         93
<210> SEQ ID NO 35
<211> LENGTH: 93
<212> TYPE: DNA
<213> ORGANISM: Varicella virus
<220> FEATURE:
<221> NAME/KEY: misc_feature
<222> LOCATION: (1)..(93)
<223> OTHER INFORMATION: Attenuated Oka strain
<400> SEQUENCE: 35
gcccgtccag cccgtccagc ccgcgcagcc cgtccagccc gcgcagcccg tc
#cagcccgt     60
ccagcccgcg cagcccgtcc agcccgcgca gga
#
#         93
<210> SEQ ID NO 36
<211> LENGTH: 75
<212> TYPE: DNA
<213> ORGANISM: Varicella virus
<220> FEATURE:
<221> NAME/KEY: misc_feature
<222> LOCATION: (1)..(75)
<223> OTHER INFORMATION: Attenuated Oka strain
<400> SEQUENCE: 36
gcccgtccag cccgtccagc ccgcgcagcc cgtccagccc gcgcagcccg cg
#cagcccgt     60
ccagcccgcg cagga
#
#
#    75
<210> SEQ ID NO 37
<211> LENGTH: 48
<212> TYPE: DNA
<213> ORGANISM: Varicella virus
<220> FEATURE:
<221> NAME/KEY: misc_feature
<222> LOCATION: (1)..(48)
<223> OTHER INFORMATION: Attenuated Oka strain
<400> SEQUENCE: 37
gcccgtccag cccgtccagc ccgcgcagcc cgtccagccc gcgcagga
#                48
<210> SEQ ID NO 38
<211> LENGTH: 30
<212> TYPE: DNA
<213> ORGANISM: Varicella virus
<220> FEATURE:
<221> NAME/KEY: misc_feature
<222> LOCATION: (1)..(30)
<223> OTHER INFORMATION: Attenuated Oka strain
<400> SEQUENCE: 38
gcccgtccag cccgtccagc ccgcgcagga
#
#           30
<210> SEQ ID NO 39
<211> LENGTH: 66
<212> TYPE: DNA
<213> ORGANISM: Varicella virus
<220> FEATURE:
<221> NAME/KEY: misc_feature
<222> LOCATION: (1)..(66)
<223> OTHER INFORMATION: Parental Oka strain
<400> SEQUENCE: 39
gcccgtccag cccgtccagc ccgcgcagcc cgtccagccc gcgcagcccg tc
#cagcccgc     60
gcagga
#
#
#           66
<210> SEQ ID NO 40
<211> LENGTH: 66
<212> TYPE: DNA
<213> ORGANISM: Varicella virus
<220> FEATURE:
<221> NAME/KEY: misc_feature
<222> LOCATION: (1)..(66)
<223> OTHER INFORMATION: Dumas strain
<400> SEQUENCE: 40
gcccgcgcag cccgcgcagc ccgcgcagcc cgcgcagccc gcgcagaccg tc
#cagcccgc     60
gcagga
#
#
#           66
<210> SEQ ID NO 41
<211> LENGTH: 308
<212> TYPE: DNA
<213> ORGANISM: Varicella virus
<220> FEATURE:
<221> NAME/KEY: misc_feature
<222> LOCATION: (1)..(308)
<223> OTHER INFORMATION: Parental Oka strain
<400> SEQUENCE: 41
ccccgccgat ggggaggggg cgcggtaccc cgccgatggg gagggggcgc gg
#taccccgc     60
cgatggggag ggggcgcggt accccgccga tggggagggg gcgcggtacc cc
#gccgatgg    120
ggagggggcg cggtaccccg ccgatgggga gggggcgcgg taccccgccg at
#ggggaggg    180
ggcgcggtac cccgccgatg gggagggggc gcggtacccc gccgatgggg ag
#ggggcgcg    240
gtaccccgcc gatggggagg gggcgcggta ccccgccgat ggggaggggg cg
#cggtaccc    300
cgccgatg
#
#
#         308
<210> SEQ ID NO 42
<211> LENGTH: 146
<212> TYPE: DNA
<213> ORGANISM: Varicella virus
<220> FEATURE:
<221> NAME/KEY: misc_feature
<222> LOCATION: (1)..(146)
<223> OTHER INFORMATION: Dumas strain
<400> SEQUENCE: 42
ccccgccgat ggggaggggg cgcggtaccc cgccgatggg gagggggcgc gg
#taccccgc     60
cgatggggag ggggcgcggt accccgccga tggggagggg gcgcggtacc cc
#gccgatgg    120
ggagggggcg cggtaccccg ccgatg
#
#             146

Claims

1. A method for the quality control of an attenuated varicella live vaccine, which comprises subjecting the genomic DNA of a sample varicella vaccine virus to sequence analysis and confirming that the genomic DNA of said sample varicella vaccine virus conserves without suffering mutation the following 5 nucleotides:the 5,745th G, the 105,356th C, the 105,544th G, the 106,262nd C and the 107,252nd C, wherein the nucleotide numbers are in accordance with the nucleotide numbering system of the nucleotide sequence of the genomic DNA of the varicella virus Dumas strain of SEQ ID NO: 1.

2. The method according to claim 1, wherein the conservation of said 5 nucleotides combination is confirmed by an RFLP analysis using the following primers:a pair of primers of SEQ ID NOs: 5 and 6 with respect to the confirmation of the 5,745th G; a pair of primers of SEQ ID NOs: 11 and 12 with respect to the confirmation of the 105,356th C and the 105,544th G; a pair of primers of SEQ ID NOs: 13 and 14 with respect to the confirmation of the 106,262nd C; and a pair of primers of SEQ ID NOs: 15 and 16 with respect to the confirmation of the 107,252nd C.

3. The method according to claim 1, which further comprises confirming that the genomic DNA of said sample varicella vaccine virus conserves without suffering mutation the following 4 nucleotides:the 122,645th G, the 123,635th G, the 124,353rd C and the 124,541st G, wherein the nucleotide numbers are in accordance with the nucleotide numbering system of the nucleotide sequence of the genomic DNA of the varicella virus Dumas strain of SEQ ID NO: 1.

4. The method according to claim 3, wherein the conservation of said 4 nucleotides is confirmed by an RFLP analysis using the following primers:a pair of primers of SEQ ID NOs: 11 and 12 with respect to the confirmation of the 124,353rd C and the 124,541st G; a pair of primers of SEQ ID NOs: 13 and 14 with respect to the confirmation of the 123,635th G; and a pair of primers of SEQ ID NOs: 15 and 16 with respect to the confirmation of the 122,645th G.

5. The method according to claim 1, which further comprises confirming that the genomic DNA of said sample varicella vaccine virus conserves without suffering mutation the following 49 nucleotides:the 560th C, the 703rd Y, the 763rd Y, the 2,515th Y, the 10,900th Y, the 12,779 the Y, the 19,431st Y, the 26,125th G, the 31,732nd Y, the 38,036th Y, the 39,227th K, the 58,595th R, the 59,287th R, the 64,067th R, the 71,252nd Y, the 82,225th R, the 84,091st R, the 87,280th R, the 87,306th Y, the 89,734th R, the 90,535th R, the 94,167th C, the 97,748th R, the 97,796th Y, the 101,089th R, the 105,169th R, the 105,310th R, the 105,705th C, the 106,710th R, the 107,136th C, the 107,599th R, the 107,797th R, the 108,111st C, the 108,838th R, the 109,137th R, the 109,200th R, the 111,640th R, the 118,247th Y, the 120,697th Y, the 120,760th Y, the 121,059th Y, the 121,786th G, the 122,100th Y, the 122,298th Y, the 122,761st G, the 123,187th Y, the 124,192nd G, the 124,587th Y, and the 124,728th Y, wherein: the nucleotide numbers are in accordance with the nucleotide numbering system of the nucleotide sequence of the genomic DNA of the varicella virus Dumas strain of SEQ ID NO: 1, R represents A or G, Y represents C or T, and K represents G or T.

6. The method according to claim 5, wherein the conservation of the 560th C, the 26,125th G, the 94,167th C, the 105,705th C, the 107,136th C, the 108,111st C, the 121,786th G, the 122,761st G and the 124,192nd G among said 49 nucleotides is confirmed by an RFLP analysis using the following primers:a pair of primers of SEQ ID NOs: 3 and 4 with respect to the confirmation of the 560th C; a pair of primers of SEQ ID NOs: 7 and 8 with respect to the confirmation of the 26,125th G; a pair of primers of SEQ ID NOs: 9 and 10 with respect to the confirmation of the 94,167th C; a pair of primers of SEQ ID NOs: 13 and 14 with respect to the confirmation of the 105,705th C and the 124,192nd G; a pair of primers of SEQ ID NOs: 15 and 16 with respect to the confirmation of the 107,136th C and the 122,761st G; and a pair of primers of SEQ ID NOs: 17 and 18 with respect to the confirmation of the 108,111st C and the 121,786th G.

7. The method according to claim 1, which further comprises confirming deletion mutations in two origins of replication of the genomic DNA of said sample varicella vaccine virus,wherein each of said deletion mutations occurs with respect to the 133rd to 141st nucleotides of the origin of replication of the varicella virus Dumas strain of SEQ ID NO:28, and wherein said two origins of replication are contained in the inverted repeats, and said two origins of replication are a region corresponding to the 110,087th to 110,350th nucleotides of the sense strand of the genomic DNA of the varicella virus Dumas strain of SEQ ID NO:1 and a region corresponding to the 119,547th to 119,810th nucleotides of the genomic DNA of the antisense strand of said Dumas strain.

8. The method according to claim 1, which further comprises confirming that the repetitive sequence of one whole R1 region of the genomic DNA of said sample varicella vaccine virus is a nucleotide sequence of abbabba′bbb′abababx (SEQ ID NO:23) arranged in the direction of from the 5′ end to the 3′ end,wherein: a represents a nucleotide sequence of GGACGCGATCGACGACGA (SEQ ID NO:19); a′ represents a nucleotide sequence of GGACGCGATTGACGACGA (SEQ ID NO:20); b represents a nucleotide sequence of GGGAGAGGCGGAGGA (SEQ ID NO:21); b′ represents a nucleotide sequence of GGACGCGGCGGAGGA (SEQ ID NO:22); and x represents a nucleotide sequence of GGA, wherein said whole R1 region is a region corresponding to the 13,937th to 14,242nd nucleotides of the genomic DNA of the varicella virus Dumas strain of SEQ ID NO: 1.

9. The method according to claim 1, which further comprises confirming that the repetitive sequence of each of two whole R4 regions of the genomic DNA of said sample varicella vaccine virus is a nucleotide sequence of aaaaaaaaaaaax (SEQ ID NO:26) arranged in the direction of from the 5′ end to the 3′ end,wherein: a represents a nucleotide sequence of CCCCGCCGATGGGGAGGGGGCGCGGTA (SEQ ID NO:24); and x represents a nucleotide sequence of CCCCGCCGATG (SEQ ID NO:25) wherein said two whole R4 regions are a region corresponding to the 109,762nd to 109,907th nucleotides of the sense strand of the genomic DNA of the varicella virus Dumas strain of SEQ ID NO: 1 and a region corresponding to the 119,990th to 120,135th nucleotides of the antisense strand of the genomic DNA of said Dumas strain.