Claims
- 1. A method for effecting reduction of the biologically active level of an undesired lipid present in the fluid media of the gastrointestinal tract of humans or animals, said undesired lipid capable of being bound by a substantially straight-chain aliphatic group ranging from 12-24 carbon atoms, comprising:orally administering therapeutically effective doses of a pharmaceutical composition containing a substantially water-soluble nondigestible polymer having multiple reactable hydroxyl groups, wherein said polymer is selected from the group consisting of cellulose polymers, algin, pectin, agar, chitin, polyvinyl alcohol and hydroxyethyl methacrylate, bonded through a biologically stable ether linkage to a substantially straight-chain aliphatic group ranging from 12-24 carbon atoms, the aliphatic group being capable of attracting and bonding, by means of van der Waals or hydrophobic forces, the undesired lipid present in the gastrointestinal tract for a time sufficient for the composition to be discharged from the gastrointestinal tract, and wherein the polymer is bonded to the aliphatic group by reacting the aliphatic group with the polymer at a ratio of 1-50% by weight of the aliphatic group relative to the polymer.
- 2. The method of claim 1 wherein the dosage ranges from about 0.1 gm/kg to 5.0 gm/kg body weight.
- 3. The method of claim 1 wherein said cellulosic polymer is selected from the group consisting of alpha cellulose, hydroxypropylmethyl cellulose, carboxymethyl cellulose, hydroxypropyl cellulose, hydroxyethyl cellulose and mixtures thereof.
- 4. The method of claim 1 wherein the undesired lipid is selected from cholesterol, cholesterol esters, fatty acids, fatty esters and derivatives thereof.
- 5. A method for effecting reduction of the biologically active level of an undesired lipid present in the fluid media of the gastrointestinal tract of humans or animals, said undesired lipid capable of being bound by a saturated or unsaturated alcohol, comprising:orally administering therapeutically effective doses of a pharmaceutical composition containing a substantially water-soluble nondigestible polymer having multiple reactable hydroxyl groups, wherein said polymer is selected from the group consisting of the group consisting of cellulose polymers, algin, pectin, agar, chitin, polyvinyl alcohol and hydroxyethyl methacrylate, bonded through a biologically stable ether linkage to a saturated or unsaturated alcohol, the saturated or unsaturated alcohol being capable of attracting and bonding, by means of van der Waals or hydrophobic forces, the undesired lipid present in the gastrointestinal tract for a time sufficient for the composition to be discharged from the gastrointestinal tract, and wherein the polymer is bonded to the saturated or unsaturated alcohol by reacting the saturated or unsaturated alcohol with the polymer at a ratio of 1-50% by weight of the saturated or unsaturated alcohol relative to the polymer.
- 6. The method of claim 5 wherein the dosage ranges from about 0.1 gm/kg to 5.0 gm/kg body weight.
- 7. The method of claim 5 wherein said cellulosic polymer is selected from the group consisting of alpha cellulose, hydroxypropylmethyl cellulose, carboxymethyl cellulose, hydroxypropyl cellulose, hydroxyethyl cellulose and mixtures thereof.
- 8. The method of claim 5 wherein the undesired lipid is selected from the group consisting of cholesterol, cholesterol esters, fatty acids, fatty esters and derivatives thereof.
CROSS-REFERENCE TO RELATED APPLICATION
This application is a continuation of U.S. patent application Ser. No. 08/234,719, filed Apr. 28, 1994 now U.S. Pat. No. 5,597,810, which is a continuation of U.S. patent application Ser. No. 07/888,396, filed May 20, 1992, now abandoned, which is a continuation of U.S. Ser. No. 07/609,013, filed Oct. 30, 1990, now abandoned, which is a continuation of U.S. Ser. No. 07/497,752, filed Mar. 20, 1990, now abandoned, which is a continuation of U.S. Ser. No. 07/382,042, filed Jul. 18, 1989, now abandoned, which is a continuation of U.S. Ser. No. 07/266,217, filed Oct. 28, 1988, now abandoned, which is a continuation of U.S. Ser. No. 07/136,476, filed Dec. 23, 1987, now abandoned, which is a continuation of U.S. Ser. No. 06/686,844, filed Dec. 27, 1984, now abandoned.
US Referenced Citations (19)
Non-Patent Literature Citations (6)
Entry |
Interaction of Proteins with Triton X-100-Substituted Sepharose 413, J. Nightingale Ju. 15, 1983 |
Hydrophobic Interaction Chromatography. J. Nightingale Journal of Chromatography, 101 (1974) 281-288. |
Non-ionic Adsorptive Immobilization of Proteins to Palmityl-(1982) Substituted Sepharose 4B. J. Nightingale Euc. J. Biochem 601-610. |
Performance of Hydrophobic Chromatography in Purification of Amylase Aug. 17, 1984. Chem. Eng. Dept. Kyoto University. |
Enzyme Immobilization on Palmityl-Sepharose. J. Nightingale Dept. of Biochemistry, Michigan State University. |
Pitha, Kociolek & Karon “Detergents Linked to Polysaccharides: Prepration & Effects on Membranes & Cells”, J. Biochem. 9411 18(1979). |
Continuations (8)
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Number |
Date |
Country |
Parent |
08/234719 |
Apr 1994 |
US |
Child |
08/485092 |
|
US |
Parent |
07/888396 |
May 1992 |
US |
Child |
08/234719 |
|
US |
Parent |
07/609013 |
Oct 1990 |
US |
Child |
07/888396 |
|
US |
Parent |
07/497752 |
Mar 1990 |
US |
Child |
07/609013 |
|
US |
Parent |
07/382042 |
Jul 1989 |
US |
Child |
07/497752 |
|
US |
Parent |
07/266217 |
Oct 1988 |
US |
Child |
07/382042 |
|
US |
Parent |
07/136476 |
Dec 1987 |
US |
Child |
07/266217 |
|
US |
Parent |
06/686844 |
Dec 1984 |
US |
Child |
07/136476 |
|
US |