Claims
- 1. A method for treating diarrhea, comprising, administering an effective amount for inhibiting Cl− secretion of an aromatic compound to a subject, wherein the aromatic compound has the general formula:
- 2. The method of claim 1, wherein the aromatic compound does not include any compound encompassed by formula (II):
- 3. The method of claim 1, wherein the aromatic compound is selected from the group consisting of aromatic compounds wherein p=0, X is absent, (C1-C3) alkyl, (C1-C3) alkenyl, (C1-C3) or alkynyl; R′ is absent, -halo, —R, —OR, —SR, —NR2, —ONR2, —NO2, —CN, —C(O)R, —C(S)R, —C(O)OR, —C(S)OR, —C(O)SR, —C(S)SR, —C(O)NR2, —C(S)NR2, —C(O)NR(OR), —C(S)NR(OR), —C(O)NR(SR), C(S)NR(SR), —CH(CN)2, —CH[C(O)R]2, —CH[C(S)R]2, —CH[C(O)OR]2, —CH[C(S)OR]2, —CH[C(O)SR]2, —CH[C(S)SR]2, or aryl; Ar1 is aryl, substituted aryl, heteroaryl other than imidazole, nitroimidazole and triazole, heteroarylium other than imidazolium, nitroimidazolium and triazolium, (C5-C8) cycloalkyl or (C5-C8) heterocycloalkyl; Ar2 is aryl or substituted aryl; and Ar3 is aryl, substituted aryl, biaryl, or heteroaryl other than imidazole, nitroimidazole and triazole.
- 4. The method of claim 2, wherein the aromatic compound is administered orally.
- 5. The method of claim 2, wherein the subject is a human.
- 6. The method of claim 5, further comprising administering an anti-diarrheal agent to the subject.
- 7. The method of claim 6, wherein the anti-diarrheal agent is an oral rehydration fluid.
- 8. The method of claim 2, wherein the aromatic compound is selected from the group consisting of 7, 10, 12, 13, 14, 15, 16, 18, 20, 21, 22, 23, 24, 27, 29, 30, 31, 32, 33, 34, 35, 37, 38, 42, 43, 44, 45, 46, 47, 49, 50, 51, 52, 53, 55, 56, 58, 59, 60, 62, 64, 65, 67, 68, 69, 70, 73, 75, 78, 79, 80, 81, 82, 83, 86, 87, 88 and 90.
- 9. A veterinary preparation comprising:
an aromatic compound in an amount effective to inhibit scours in a subject, the aromatic compound having the general formula: 107or a pharmaceutically acceptable salt or hydrate thereof, wherein: n is 0, 1, 2, 3 or 4; p is 0 or 1; X is absent, (C1-C3) alkyl, (C1-C3) alkenyl, (C1-C3) alkynyl, SCH2, OCH2,or NOCH2; Y is C, N, P, Si or Ge; R′ is absent, -halo, —R, —OR, —SR, —NR2, —ONR2, —NO2, —CN, —C(O)R, —C(S)R, —C(O)OR, —C(S)OR, —C(O)SR, —C(S)SR, —C(O)NR2, —C(S)NR2, —C(O)NR(OR), —C(S)NR(OR), —C(O)NR(SR), C(S)NR(SR), —CH(CN)2, —CH[C(O)R]2, —CH[C(S)R]2, —CH[C(O)OR]2, —CH[C(S)OR]2, —CH[C(O)SR]2, —CH[C(S)SR]2, aryl, or heteroaryl; Ar1 is aryl, substituted aryl, heteroaryl, (C5-C8) cycloalkyl or (C5-C8) heterocycloalkyl; Ar2 is aryl or substituted aryl; Ar3 is aryl, substituted aryl, biaryl, biphenyl, bibenzyl, or heteroaryl other than imidazole, nitroimidazole and triazole; each R is independently selected from the group consisting of —H, (C1-C6) alkyl, substituted (C1-C6) alkyl, (C1-C6) alkenyl, substituted (C1-C6) alkenyl (C1-C6) alkynyl, substituted (C1-C6) alkynyl, and (C1-C6) alkoxy; the aryl substituents are each independently selected from the group consisting of -halo, trihalomethyl, —R, —R1, —OR1, —SR1, NR12, —NO2, —CN, —C(O)R1, —C(S)R1, —C(O)OR1, —C(S)OR1, —C(O)SR1 and —C(S)SR1; the alkyl, alkenyl and alkynyl substituents are each independently selected from the group consisting of -halo, —R1, —OR1, —SR1, N(R1)2, —NO2, —CN, —C(O)R1, —C(S)R1, —C(O)OR1, —C(S)OR1, —C(O)SR1, —C(S)SR1, aryl, γ-butyrolactonyl, pyrrolidinyl and succinic anhydridyl; and each R1 is independently selected from the group consisting of —H, (C1-C6) alkyl, (C1-C6) alkenyl and (C1-C6) alkynyl. ; and, an anti-scours agent
- 10. A veterinary preparation as in claim 9, wherein the aromatic compound does not include any compound encompassed by formula (II):
- 11. The veterinary preparation as in claim 9, wherein the anti-scours agent is a colostral extract.
- 12. The veterinary preparation as in claim 9, wherein the anti-scours agent is an immunological preparation of colostrum.
- 13. The veterinary preparation as in claim 9, wherein the anti-scours agent is a microorganism specific immunological preparation.
- 14. The veterinary preparation as in claim 9, wherein the anti-scours agent is an oral rehydration fluid.
- 15. The veterinary preparation as in claim 9, wherein the anti-scours agent is a replacement electrolyte composition.
- 16. The veterinary preparation as in claim 9, wherein the anti-scours agent is an antibiotic composition.
- 17. The veterinary preparation as in claim 9, wherein the veterinary preparation is a dry preparation.
- 18. The veterinary preparation as in claim 9, wherein the aromatic compound is selected from the group consisting of 7, 10, 12, 13, 14, 15, 16, 18, 20, 21, 22, 23, 24, 27, 29, 30, 31, 32, 33, 34, 35, 37, 38, 42, 43, 44, 45, 46, 47, 49, 50, 51, 52, 53, 55, 56, 58, 59, 60, 62, 64, 65, 67, 68, 69, 70, 73, 75, 78, 79, 80, 81, 82, 83, 86, 87, 88 and 90.
- 19. A pharmaceutical preparation, comprising:
an aromatic compound in an amount effective to inhibit diarrhea, the aromatic compound having the general formula: 109or a pharmaceutically acceptable salt or hydrate thereof, wherein: n is 0, 1, 2, 3 or 4; p is 0 or 1; X is absent, (C1-C3) alkyl, (C1-C3) alkenyl, (C1-C3) alkynyl, SCH2, OCH2,or NOCH2; Y is C, N, P, Si or Ge; R′ is absent, -halo, —R, —OR, —SR, —NR2, —ONR2, —NO2, —CN, —C(O)R, —C(S)R, —C(O)OR, —C(S)OR, —C(O)SR, —C(S)SR, —C(O)NR2, —C(S)NR2, —C(O)NR(OR), —C(S)NR(OR), —C(O)NR(SR), C(S)NR(SR), —CH(CN)2, —CH[C(O)R]2, —CH[C(S)R]2, —CH[C(O)OR]2, —CH[C(S)OR]2, —CH[C(O)SR]2, —CH[C(S)SR]2, aryl, or heteroaryl; Ar1 is aryl, substituted aryl, heteroaryl, (C5-C8) cycloalkyl or (C5-C8) heterocycloalkyl; Ar2 is aryl or substituted aryl; Ar3 is aryl, substituted aryl, biaryl, biphenyl, bibenzyl, or heteroaryl other than imidazole, nitroimidazole and triazole; each R is independently selected from the group consisting of —H, (C1-C6) alkyl, substituted (C1-C6) alkyl, (C1-C6) alkenyl, substituted (C1-C6) alkenyl (C1-C6) alkynyl, substituted (C1-C6) alkynyl, and (C1-C6) alkoxy; the aryl substituents are each independently selected from the group consisting of -halo, trihalomethyl, —R, —R1, —OR1, —SR1, NR12, —NO2, —CN, —C(O)R1, —C(S)R1, —C(O)OR1, —C(S)OR1, —C(O)SR1 and —C(S)SR1; the alkyl, alkenyl and alkynyl substituents are each independently selected from the group consisting of -halo, —R1, —OR1, —SR1, N(R1)2, —NO2, —CN, —C(O)R1, —C(S)R1, —C(O)OR1, —C(S)OR1, —C(O)SR1, —C(S)SR1, aryl, γ-butyrolactonyl, pyrrolidinyl and succinic anhydridyl; and each R1 is independently selected from the group consisting of —H, (C1-C6) alkyl, (C1-C6) alkenyl and (C1-C6) alkynyl; and, an anti-diarrheal agent.
- 20. The pharmaceutical preparation as in claim 19, wherein the aromatic compound does not include any compound encompassed by formula (II):
- 21. The pharmaceutical preparation as in claim 20, wherein the aromatic compound is selected from the group consisting of 7, 10, 12, 13, 14, 15, 16, 18, 20, 21, 22, 23, 24, 27, 29, 30, 31, 32, 33, 34, 35, 37, 38, 42, 43, 44, 45, 46,47, 49, 50, 51, 52, 53, 55, 56, 58, 59, 60, 62, 64, 65, 67, 68, 69, 70, 73, 75, 78, 79, 80, 81, 82, 83, 86, 87, 88 and 90.
- 22. The pharmaceutical preparation as in claim 20, wherein the anti-diarrheal agent is an oral rehydration fluid.
- 23. The pharmaceutical preparation as in claim 20, wherein the anti-diarrheal agent is an antibiotic.
- 24. The pharmaceutical preparation as in claim 20, wherein the anti-diarrheal agent is an electrolyte composition.
- 25. The pharmaceutical preparation as in claim 20, wherein the anti-diarrheal agent is an immunoglobulin preparation from bovine colostrum.
- 26. The pharmaceutical preparation as in claim 20, wherein the anti-diarrheal agent is an oral sugar-electrolyte solution.
- 27. A method for treating scours, the method comprising the step of:
administering to a subject in need of such treatment, an aromatic compound in an amount effective to inhibit scours, wherein the aromatic compound has the general formula: 111or a pharmaceutically acceptable salt or hydrate thereof, wherein: n is 0, 1, 2, 3 or 4; p is 0 or 1; X is absent, (C1-C3) alkyl, (C1-C3) alkenyl, (C1-C3) alkynyl, SCH2, OCH2,or NOCH2; Y is C, N, P, Si or Ge; R′ is absent, -halo, —R, —OR, —SR, —NR2, —ONR2, —NO2, —CN, —C(O)R, —C(S)R, —C(O)OR, —C(S)OR, —C(O)SR, —C(S)SR, —C(O)NR2, —C(S)NR2, —C(O)NR(OR), —C(S)NR(OR), —C(O)NR(SR), C(S)NR(SR), —CH(CN)2, —CH[C(O)R]2, —CH[C(S)R]2, —CH[C(O)OR]2, —CH[C(S)OR]2, —CH[C(O)SR]2, —CH[C(S)SR]2, aryl, or heteroaryl; Ar1 is aryl, substituted aryl, heteroaryl, (C5-C8) cycloalkyl or (C5-C8) heterocycloalkyl; Ar2 is aryl or substituted aryl; Ar3 is aryl, substituted aryl, biaryl, biphenyl, bibenzyl, or heteroaryl other than imidazole, nitroimidazole and triazole; each R is independently selected from the group consisting of —H, (C1-C6) alkyl, substituted (C1-C6) alkyl, (C1-C6) alkenyl, substituted (C1-C6) alkenyl (C1-C6) alkynyl, substituted (C1-C6) alkynyl, and (C1-C6) alkoxy; the aryl substituents are each independently selected from the group consisting of -halo, trihalomethyl, —R, —R1, —OR1, —SR1, NR12, —NO2, —CN, —C(O)R1, —C(S)R1, —C(O)OR1, —C(S)OR1, —C(O)SR1 and —C(S)SR1; the alkyl, alkenyl and alkynyl substituents are each independently selected from the group consisting of -halo, —R1, —OR1, —SR1, N(R1)2, —NO2, —CN, —C(O)R1, —C(S)R1, —C(O)OR1, —C(S)OR1, —C(O)SR1, —C(S)SR1, aryl, γ-butyrolactonyl, pyrrolidinyl and succinic anhydridyl; and each R1 is independently selected from the group consisting of —H, (C1-C6) alkyl, (C1-C6) alkenyl and (C1-C6) alkynyl.
- 28. The method for treating scours as in claim 27,wherein the aromatic compound does not include any compound encompassed by formula (II):
- 29. The method for treating scours as in claim 27, wherein the aromatic compound is selected from the group consisting of 7, 10, 12, 13, 14, 15, 16, 18, 20, 21, 22, 23, 24, 27, 29, 30, 31, 32, 33, 34, 35, 37, 38, 42, 43, 44, 45, 46, 47, 49, 50, 51, 52, 53, 55, 56, 58, 59, 60, 62, 64, 65, 67, 68, 69, 70, 73, 75, 78, 79, 80, 81, 82, 83, 86, 87, 88 and 90.
- 30. The method for treating scours as in claim 28, wherein the aromatic compound is administered orally.
- 31. The method for treating scours as in claim 28, wherein the subject is selected from the group consisting of a horse, a cow, a pig, and a goat.
- 32. The method for treating scours as in claim 28, further comprising administering an anti-scours agent to the subject.
CROSS-REFERENCE TO RELATED APPLICATIONS
[0001] This application is a continuation-in-part of application Ser. No. 08/621,169, filed Mar. 20, 1996, now pending, which is incorporated herein in its entirety by reference.
Divisions (1)
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Number |
Date |
Country |
Parent |
09159399 |
Sep 1998 |
US |
Child |
10290861 |
Nov 2002 |
US |
Continuations (1)
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Number |
Date |
Country |
Parent |
08621169 |
Mar 1996 |
US |
Child |
09159399 |
Sep 1998 |
US |