METHOD FOR THE AUTOMATIC CONTROL OF THE AMOUNT OF ACTIVE INGREDIENT OF TABLETS DURING THE PRODUCTION IN A ROTARY TABLET PRESS

Abstract

Method for the automatic control of the amount of active ingredient of tablets during the production in a rotary tablet press, which has a die table with die bores, upper and lower punches assigned to the die bores, a filling station, a metering cam for the lower punches in the filling station, at least one pressing station with at least one upper and one lower pressing roller, wherein at least the lower pressing roller is adjustable with respect to the other pressing roller by means of a pressing roller adjustment equipment, a metering cam adjustment equipment for height adjustment of the metering cam, a compression force measuring equipment at the pressing station, a control- and operating computer and an active ingredient measuring equipment, characterised by the following procedural steps: during the tablet production, the amount of active ingredient of tablets is measured and values for the amount of active ingredient are compared with a predetermined desired active ingredient value in the control- and operating computer, andthe metering cam is adjusted in accordance with the deviation of the measured amount of active ingredient from the desired active ingredient value.

Description

BRIEF DESCRIPTION OF THE SEVERAL VIEWS OF THE DRAWINGS

FIG. 1 shows schematically a part of a rotary press for the production of tablets, with an automatic control of the active ingredient content of the tablets.

DETAILED DESCRIPTION OF THE INVENTION

While this invention may be embodied in many different forms, there are described in detail herein a specific preferred embodiment of the invention. This description is an exemplification of the principles of the invention and is not intended to limit the invention to the particular embodiment illustrated

In FIG. 1, a dismanteled rotor 10 of a rotary tablet press is represented in a schematic manner. It contains a die table 12 with die bores 14, to each one of which one lower punch 16 and one upper punch 18 is assigned. The pressing punches are guided by individual guiding cam elements 20 and 22, respectively. They will not be described in detail, with the exception of a filling cam element 24 and a metering cam element 26. Besides, the rotor 10 contains punch guideways 28 and 30, respectively. A filling station 32 is assigned to the rotor, which subsequently fills pressing material 34 into individual die bores 14. Such equipments are commonly known and will not be explained in more detail. The filling cam element 24 for the lower punches 16 takes care that the lower punches have a predetermined position during filling. The metering cam element 26 causes a minimum lifting of the lower punches after the filling process, through which the definite amount which is to be accommodated by the die bores 14 is predetermined. In the production direction, which is indicated by an arrow 36, two pressing stations 38 and 40, respectively, are arranged behind the filling station 32, each one with an upper pressing roller 42 and 44, respectively, and a lower pressing roller 46 and 48, respectively. Thus, 38 is the pre-pressing station and 40 the main pressing station. With the aid of the pressing stations 38, 40, the pressing material 34 in the die bores 14 is pressed to a tablet. Downstream in the production direction after the main pressing station 40, the upper punches 18 are drawn back and the tablets 50 are ejected with the aid of the lower punches 16 and the ejection cam 22. Subsequently, stripping them off from the upper side of the die table 12 takes place, which is not shown, however.

At 52 it is wanted to indicate that one or some of the produced tablets 50 are branched off to a checker device 54 for active ingredient and/or weight. The digitalised values for the amount of active ingredient of the tablets and the weight thereof from the checker device are given up to a control- and operating computer 56, which for the rest is also otherwise controlling or automatically controlling, respectively, the operation of the tablet press.

The pressing rollers 42, 44 and 46 are drawn so as to be stationary in the figure. Normally, the pressing rollers are realised as to be shiftable in height. The pressing roller 48 is mounted in a guideway 58, also as being shiftable in height, and can be adjusted with respect to the upper pressing roller 44 with the aid of a pressing roller adjustment equipment 60, in order to change the cylindrical height of a tablet and/or to vary the compression force.

Besides, a compression force measuring equipment 62 is assigned to the lower pressing roller 48, the values of which are given up to the control- and operating computer 56 in a digitalised form.

The metering cam element 26 is also adjustable in the height with the aid of a metering cam adjustment equipment 64. Through this, the amount of the pressing material to be filled into the die bores 14 is changeable.

In the control- and operating computer 56, the value for the measured amount of active ingredient is compared with a desired value. When the measured value differs from the desired value, a signal in accordance with the control deviation is given up to the pressing roller adjustment equipment 60 via the function line 66, which adjusts the pressing roller. Through this, the compression force measuring equipment 62 measures a changed compression force. This measurement is given up to the control- and operating computer 56 via the function line 68. The control- and operating computer compares the measured compression force value with a desired compression force value. In the case of a deviation, an actuating signal in accordance with the control deviation is given up to the metering cam adjustment equipment 64, through which the amount filled into the die bores 14 is changed.

When the amount of active ingredient is too small, the pressing roller 48 is moved downward by the adjustment equipment 58. Through this, the actual compression force is diminished. The control deviation of the compression forces, which is detected in the control- and operating computer 56, leads to an adjustment of the metering cam 26, through which the actual compression force approaches the desired compression force again. When the amount of active ingredient is too big, it is proceeded in a reverse manner, i.e. adjustment of the pressing roller 48 towards the upside takes place. The compression force difference established thereafter leads to a decrease of the material that is filled in, so that actual and desired values of the compression force approach each other again.

As has been already mentioned, the amount of active ingredient can be measured and automatically controlled absolutely. However, it is also possible to measure and automatically control the ratio to weight, thus the proportion of the active ingredient.

The above disclosure is intended to be illustrative and not exhaustive. This description will suggest many variations and alternatives to one of ordinary skill in this art. All these alternatives and variations are intended to be included within the scope of the claims where the term “comprising” means “including, but not limited to”. Those familiar with the art may recognize other equivalents to the specific embodiments described herein which equivalents are also intended to be encompassed by the claims.

Further, the particular features presented in the dependent claims can be combined with each other in other manners within the scope of the invention such that the invention should be recognized as also specifically directed to other embodiments having any other possible combination of the features of the dependent claims. For instance, for purposes of claim publication, any dependent claim which follows should be taken as alternatively written in a multiple dependent form from all prior claims which possess all antecedents referenced in such dependent claim if such multiple dependent format is an accepted format within the jurisdiction (e.g. each claim depending directly from claim 1 should be alternatively taken as depending from all previous claims). In jurisdictions where multiple dependent claim formats are restricted, the following dependent claims should each be also taken as alternatively written in each singly dependent claim format which creates a dependency from a prior antecedent-possessing claim other than the specific claim listed in such dependent claim below.

This completes the description of the preferred and alternate embodiments of the invention. Those skilled in the art may recognize other equivalents to the specific embodiment described herein which equivalents are intended to be encompassed by the claims attached hereto.

Claims

1. Method for the automatic control of the amount of active ingredient of tablets during the production in a rotary tablet press, which has a die table with die bores, upper and lower punches assigned to the die bores, a filling station, a metering cam for the lower punches in the filling station, at least one pressing station with at least one upper and one lower pressing roller, wherein at least the lower pressing roller is adjustable with respect to the other pressing roller by means of a pressing roller adjustment equipment, a metering cam adjustment equipment for height adjustment of the metering cam, a compression force measuring equipment at the pressing station, a control- and operating computer and an active ingredient measuring equipment, characterised by the following procedural steps: during the tablet production, the amount of active ingredient of tablets is measured and values for the amount of active ingredient are compared with a predetermined desired active ingredient value in the control- and operating computer, andthe metering cam is adjusted in accordance with the deviation of the measured amount of active ingredient from the desired active ingredient value.

2. Method according to patent claim 1, characterised in that during the tablet production, the compression forces on the lower and/or upper pressing roller are measured, and the control- and operating computer compares the measured values with a predetermined desired value of the compression force, the lower pressing roller is adjusted in accordance with the deviation when there is a deviation of the measured amount of active ingredient from the desired value, and the metering cam is adjusted in accordance with the control deviation of the compression force values.

3. Method according to patent claim 1, characterised in that the active ingredient measuring equipment measures also the weight of the tablets, and the control- and operating computer compares the relation of a measured amount of active ingredient to the weight with the relation of a predetermined desired value for the amount of active ingredient to the weight.

4. Method according to patent claim 1, characterised in that the measurement of the amount of active ingredient is performed in the tablet press.

5. Method according to patent claim 1, characterised in that the measurement of the amount of active ingredient and, as the case may be, of the weight of the tablets is performed in an external device.

6. Method according to patent claim 1, characterised in that the measurement of the amount of active ingredient is performed by the NIRS or LIF method.