The invention concerns a method for medical treatment of patients with a laser beam from a semiconductor or diode laser, as well as a corresponding device.
Laser systems now represent an essential tool in medicine. They permit precise, point-like and contactless work. There are a variety of laser systems for medical applications. Of central significance here for each laser is its active medium, which stipulates the emission wavelength and therefore the area of application of the laser in medicine. The choice is essentially made by the wavelength-dependent absorption of the laser radiation in tissue.
Different laser systems are used both in human medicine, as for example, eye surgery, dermatology, plastic surgery, gynecology, neurosurgery, urology and dentistry and in veterinary medicine. In dentistry the laser is used, for example, to treat parodontosis and gum diseases, and as a drill replacement.
The basis of generation of laser radiation is always stimulated emission. By excitation of atoms or molecules in a laser-active medium, occupation of higher energy levels occurs, which are responsible for the laser transition. If excitation is strong enough in order to generate (pump) an overpopulation of the upper laser level, one speaks of population inversion. Ultimately, as a result of spontaneous emission transition to stimulated emission, an artificially generated depopulation of the upper laser level and emission of laser beams occur.
The method with which the laser medium is excited depends on the employed laser medium. The three most essential excitation types are
Semiconductors are used in diode lasers as active medium, which during excitation emit a coherent beam in the visible and near-infrared spectral range. The energy states of the electrons in semiconductors are not sharp, as in free atoms, but produce broad bands. The ground state is formed by the valence band, the excited state by the conduction band. Excitation ordinarily occurs at the so-called pn-transition after application of external voltage. The electrons are passed from the valence band into the conduction band, which leads to population inversion. During subsequent stimulated emission they return to the valence band and then emit light. The emission wavelength depends on the energy distance between the valence and conduction band, the band distance being obtained from selection of appropriate semiconductor compounds.
Diode lasers have been used in medicine since the mid-90s. The main areas of application are coagulation (hemostasis), surgery (ablation of soft tissue) and elimination of disease pathogens. In addition, high-powered diode lasers, as described in DE 10 2004 006 932, can also be used for hair removal (epilation).
Diode lasers have been successfully used in dentistry since the mid-90s for surgical incision, killing of germs, soft laser therapy and bleaching of teeth. Whereas a power of 1 to 3 watts is sufficient for the mentioned applications, the initial power of the device in surgical incisions influences the cutting speed. A higher output power is therefore desirable here. The devices offered on the market, however, only reach an increase in cutting speed by output powers to 15 watts.
Diode lasers are available in several discrete wavelengths. For example, wavelengths of 635 nm (visible, red), 810 nm, 940 nm and 980 nm (all infrared, invisible) are known with sufficient power for the described situations. There are additional wavelengths that have insufficient output power for the described applications.
Diode lasers of 810 nm and 980 nm are mostly used in dentistry.
The action principle of these diode lasers on the patient is absorption of laser light by biological tissue. Absorption by water is insignificant in this wavelength range (0.01 to 0.1%). The essential action mechanism develops by absorption of laser light by melanin (skin) or hemoglobin (red blood dye). Surgical incisions with a diode laser therefore require tissue with good blood supply.
Unlike other laser systems (gas or solid lasers), which are capable of storing optical energy and releasing it in a short pulse, diode lasers can only be switched on and off like an incandescent lamp. Whereas a solid laser, like an Nd:YAG laser, can release an energy pulse of more than one joule in a short time (typically a few μs), which corresponds to a peak power of several thousand watts, the diode laser can only be switched on with a maximum power (typically 2 to 15 watts). If this occurs in a period of few μS, as in Nd:YAG lasers, energies of only a few mJ are reached. Diode lasers are therefore mostly operated in medical applications continuously (CW) or with relatively long quasipulses (a few ms).
For the thermal effect on biological tissue, however, the energy release behavior over time is enormously important. If the laser energy is released in a short pulse, the thermal load on the tissue is lower. With extremely short pulses in the ns-fs range (femtosecond lasers), thermal energy transferred to the tissue no longer occurs at all.
In diode lasers with increasing laser power, with which the cutting speed in surgical applications can be increased, the thermal load leads to burning of the tissue. This is referred to as carbonization and means: carbonized tissue. Because of this wound healing is disturbed and toxic byproducts occur. The thermal effect of carbonization therefore limits the maximum useable laser power and therefore the cutting speed.
Another aspect of previously known diode lasers is poor coupling of the laser radiation into the tissue. The less hemoglobin contained in the tissue, the less laser radiation is absorbed by the tissue. In dental practice this is often a problem because blood supply is reduced by anesthetics. The laser beam then often shows no or only a weak reaction on the irradiated tissue.
The task of the present invention is to make a diode laser more appropriate for medical application.
Applying the laser beam in the form of pulses on the area being treated leads to solution of the task.
This means the pulse behavior of solid lasers, like the Nd:YAG laser, is stimulated with a diode laser in order to eliminate the effects described above.
One requirement for such a diode laser system is a laser source that has sufficient power. For this purpose at least 5 watts, preferably 25 to 50 watts permanent power should be available. The higher the maximum output power, the higher the pulse energy at a specified time interval. In addition, the laser source must have the correct wavelength. The range between 700 to 1050 nm works here. Laser sources with 810 nm are preferably used because absorption in hemoglobin is very good here. The same also applies for a laser source with a wavelength of 940±10 nm.
The switch-on time of the laser should lie in the range from 2 to 500 μs, preferably 10 to 50 μs and the pause time between two pulses should be greater than the pulse time, preferably 2 to 5 times as long as the pulse time so that surgical cutting with significantly increased speed occurs without interfering carbonization effects. Another observation is that coupling into completely anemic tissue without blood supply even occurs.
The electronic control that furnishes the current for the laser diode is set in a preferred practical example permanently during operation at a value that is just below the value at which the laser diode begins to generate laser energy. The control is briefly induced to switch on the maximum admissible current of the laser diode. This process is periodically repeated.
The best results can be achieved with rectangular pulse forms. Because of restrictions of power supply, rectangular pulse forms, however, are not possible in very short pulses (<50 μs). Because of the finite rise and fall times the pulse will be Gaussian or bell-shaped. An essential point for a Gaussian pulse is a steeply rising flank in order to quickly reach the maximum pulse energy.
Quartz fibers are often used to apply laser radiation. The smaller the diameter of the quartz fiber, the greater effect on the tissue because the power density in thinner fibers increases quadratically.
For application of laser light a hand piece is situated on the distal end of the transmission fiber, which permits the physician to apply the laser energy in targeted fashion. In a special variant this hand piece is designed in two parts and provided with coupling optics. In this way transmission fibers and application fibers are separated. Because of this the entire fiber need not be replaced during damage or soiling, but only the application part.
A useful supplement to the described system is expansion by a second laser source, preferably an Er:YAG laser source. All conceivable applications could be conducted in dentistry with it.
Additional advantages, features and details of the invention are apparent from the following description of the preferred practical examples and with reference to the drawing; in the drawing
According to
Since the rectangular shape can only be achieved with difficulty in a diode laser, generally the pulses 1.3 and 1.4 according to the method of the invention must be emitted in the form of a Gaussian curve. This is shown in
A particular preferred variant of the method according to the invention is shown in
Number | Date | Country | Kind |
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10 2005 055 523.3 | Nov 2005 | DE | national |
Filing Document | Filing Date | Country | Kind | 371c Date |
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PCT/EP2006/011003 | 11/16/2006 | WO | 00 | 5/26/2009 |