Method for the preparation of dicarboxylic imides

Abstract

The present invention relates to a method for the preparation of a carboxylic imide having the general formula

Description

Claims

1. A method for the preparation of a dicarboxylic imide having the general formula (I) R1—(CO)—(NR3)—(CO)—R2   (I),wherein a dicarboxylic imide having the general formula (II) R1—(CO)—O—(CO)—R2   (II)is reacted with urea or a urea derivative of the form (R3HN)—(CO)—(NR3H) in a solvent to form a dicarboxylic imide (I),whereinR1, R2 and R3 independently of one another can be substituted or unsubstituted, unbranched or branched or cyclic C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, C4-C10 aryl, C4-C10 heteroaryl, or wherein R1 and R2 can be bound to each other to form a ring, and/or wherein R3 can also be H.

2. The method of claim 1 for the preparation of dicarboxylic imides having the general formula (III)

3. The method of claim 2 for the preparation of substituted or unsubstituted piperidine-2,6-diones wherein R4 is a substituted or unsubstituted 1,3-propanediyl.

4. The method of claim 3 for the preparation of unsubstituted or substituted 3-phthalimidopiperidine-2,6-diones wherein R4 is an unsubstituted or a substituted 1-phthalimido-1,3-propanediyl.

5. The method of claim 1 wherein the solvent is a high-boiling solvent having a boiling point of more than 150° C., preferably of more than 170° C., most preferably of more than 190° C.

6. The method of claim 1 wherein the solvent is selected from the group consisting of aprotic sulfones, saturated lactames, carboxylic amides, ethers, ureas, polyethylene glycols, aromatics substituted by one or more alkyl groups, ionic liquids, siloxanes, saturated or partially saturated carbocycles, carbonic esters, aromatic amines, or the mixtures thereof.

7. The method of claim 6 wherein the aprotic sulfone is tetrahydrothiophene-1,1-dioxide (sulfolane), the saturated lactame is N-methyl pyrrolidone (NMP), the carboxylic amide is N,N-dimethyl acetamide (DMA) or formamide, the ether is diphenyl ether, the urea is 1,3-dimethyl-2-imidazolidinone (DMI), the polyethylene glycol is diethyleneglycol diethylether, the aromatic substituted by one or more alkyl groups is selected from diethylbenzene, pseudocumene, cumene or mesitylene, the ionic liquid is 1-ethyl-3-methyl imidazolium tosylate, the siloxane is decamethylcyclopentasiloxane, the saturated or partially saturated carbocycle is tetraline or decaline, the carbonic ester is propylene carbonate, and/or the aromatic amine is N,N-diethylaniline, and wherein tetrahydrothiophene-1,1-dioxide is preferably used as the aprotic sulfone.

8. The method of claim 1 wherein the temperature during the reaction is in a range of 140° C. to 220° C., preferably in a range of 150° C. to 210° C., even more preferably in a range of 160° C. to 200° C.

9. The method of claim 1 wherein the substances are reacted under atmospheric pressure.

10. The method of claim 1 wherein in addition a foam inhibitor is employed.

11. The method of claim 10 wherein the foam inhibitor is selected from the group consisting of decaline and tetraline.

12. The method of claim 1 wherein the dicarboxylic imide (I) is purified in a subsequent step by recrystallization or by chromatographic purification procedures.

13. The method of claim 12 wherein for recrystallization of the dicarboxylic imide (I) a suitable solvent or solvent mixture, preferably a solvent or solvent mixture selected from the group consisting of methanol, ethanol, a mixture of DMF and water, a mixture of ethylether and methanol, and a mixture of ethylether and ethanol is employed.