Claims
- 1. A method of preventing the onset of cachexia and/or anorexia or treating existing cachexia and/or anorexia in a human, said method comprising enterally administering to the human on a daily basis at least:
(a) an oil blend containing ω-6 fatty acids and at least 450 mg of ω-3 fatty acids, the weight ratio of ω-6 fatty acids to ω-3 fatty acids being from about 0.1 to about 3.0; and (b) a source of amino-nitrogen wherein 15% to 50% by weight of the amino acids of said source of amino-nitrogen are branched-chain amino acids; and (c) an antioxidant component comprising at least one nutrient selected from the group comprising beta-carotene, vitamin C, vitamin E, selenium, and mixtures thereof; wherein at least said oil blend and said antioxidant are present in a liquid nutritional matrix.
- 2. The method according to claim 1, further comprising administering to the human a source of amino-nitrogen wherein tryptophan is present in an amount of less than about 5.0% by weight of the total amount of the amino acids present in said source of amino-nitrogen.
- 3. The method according to claim 1, further comprising administering to the human a source of amino-nitrogen wherein 15% to 25% by weight of the amino acids of said source of amino-nitrogen are branched-chain amino acids.
- 4. The method according to claim 1 which further comprises daily administering to the human:
(a) an oil blend containing ω-6 fatty acids and at least 1000 mg of ω-3 fatty acids, the weight ratio of ω-6 fatty acids to ω-3 fatty acids being from 0.1 to 1.0; and (b) a source of amino-nitrogen wherein 15% to 25% by weight of the amino acids are branched-chain amino acids, and wherein tryptophan is present in an amount of less than 3.0% by weight of the total amount of the amino acids present in said source of amino-nitrogen; and (c) an antioxidant mixture comprising beta-carotene, vitamin C, vitamin E and selenium.
- 5. The method of claim 4 wherein the antioxidant system of component (c) comprises about 2,500 to about 6,500 micrograms beta-carotene, about 250 to about 1,000 milligrams vitamin C, about 100 to about 500 I.U. vitamin E and about 75 to about 125 micrograms selenium per liter.
- 6. The method of claim 1 in which the ω-3 fatty acids comprise from about 15 to about 30% by weight of the total fatty acids and are selected from the group consisting of alpha-linolenic acid, stearidonic acid, eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid.
- 7. The method of claim 6 in which the ω-3 fatty acids comprise from about 15 to about 40% by weight of the total fatty acids and are selected from the group consisting of eicosapentaenoic acid and docosahexaenoic acid.
- 8. The method of claim 7 in which at least about 15% by weight of the total fatty acids is eicosapentaenoic acid.
- 9. The method of claim 1 wherein the weight ratio of ω-6 fatty acids to ω-3 fatty acids in said oil blend is from about 0.1 to about 1.0; about 15% to about 25% by weight of the amino acids of said source of amino-nitrogen are branched-chain amino acids; and said antioxidant component comprises a mixture of beta-carotene, vitamin C, vitamin E and selenium.
- 10. The method according to claim 1 which further comprises daily administering to the human:
(a) an oil blend containing ω-6 fatty acids and at least 1000 mg of ω-3 fatty acids, the weight ratio of ω-6 fatty acids to ω-3 fatty acids being from 0.1 to 1.0; and (b) a source of amino-nitrogen wherein 15% to 25% by weight of the amino acids are branched-chain amino acids, and wherein tryptophan is present in an amount of less than 5.0% by weight of the total amount of the amino acids present in said source of amino-nitrogen.
- 11. The method of claim 10 comprising feeding eicosapentaneoic acid as the ω-3 fatty acid.
- 12. A liquid nutritional composition comprising per liter:
(a) at least 450 mg of ω-3 fatty acids and wherein the weight ratio of ω-6 fatty acids to ω-3 fatty acids is from about 0.1 to about 3.0; (b) at least 50 grams of a source of amino-nitrogen wherein 15 to 50% by weight of the amino-nitrogen is branched-chain amino acids and wherein tryptophan is present in an amount less than about 5.0% by weight of the total amino-nitrogen; and (c) at least 1 gram of an antioxidant system comprising beta-carotene, vitamin C, vitamin E and selenium.
- 13. The composition according to claim 12, wherein the weight ratio of ω-6 fatty acids to ω-3 fatty acids is from about 0.1 to about 1.0, and wherein 15 to 25% by weight of the amino-nitrogen is branched-chain amino acids.
- 14. The composition according to claim 13, further comprising at least 1000 mg of ω-3 fatty acids per liter.
- 15. A liquid nutritional composition according to claim 12 wherein:
(a) at least 500 mg of ω-3 fatty acids are present and the weight ratio of ω-6 fatty acids to ω-3 fatty acids is from 0.2 to 2.0; (b) tryptophan is present in an amount of less than 3.0% by weight of the total amino-nitrogen; and (c) at least 2.0 grams of said antioxidant system is present per liter.
- 16. A method of preventing the onset of anorexia or of treating existing anorexia in a human comprising administering to the human a nutritional composition comprising amino acids wherein about 5 to 25 grams of branched-chain amino acids selected from valine, leucine, isoleucine, or mixtures thereof are present in an amount from about 15% to about 50% by weight of the total amount of amino acids present in said composition, and wherein tryptophan in an amount not greater than about 5.0 % by weight of the total amount of amino acids is present in said composition and wherein ω-6 and ω-3 fatty acids are present at a weight ratio of from about 0.1 to about 3.0 and at least one antioxidant is present in the nutritional composition.
- 17. A method for preventing immunosuppression in a human comprising administering to the human a liquid nutritional composition comprising:
(a) an oil blend containing ω-6 and ω-3 fatty acids, the weight ratio ω-6 fatty acids to ω-3 fatty acids being about from 0.1 to about 3.0; and (b) an antioxidant component comprising about 2,500 to about 6,500 micrograms per liter beta-carotene, about 250 to about 1,000 milligrams per liter vitamin C, about 100 to about 500 I.U. per liter vitamin E, and about 75 to about 125 microgram per liter selenium.
- 18. The method of claim 17 in which at least 400 mL of said liquid nutritional composition are administered to said human per day.
- 19. A method for enhancing the transport and efficacy of anticancer drugs in a human having a cancerous condition comprising administering to the human a nutritional composition comprising an oil blend containing ω-6 and ω-3 fatty acids, the weight ratio of total ω-6 fatty acids to ω-3 fatty acids being from about 0.1 to about 3.0.
Parent Case Info
[0001] This application is a continuation-in-part of prior application Ser. No. 08/635,179 filed Apr. 25, 1996, which is hereby incorporated by reference.
Divisions (1)
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Number |
Date |
Country |
Parent |
08842454 |
Apr 1997 |
US |
Child |
09479550 |
Jan 2000 |
US |
Continuations (2)
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Number |
Date |
Country |
Parent |
09642630 |
Aug 2000 |
US |
Child |
10002179 |
Dec 2001 |
US |
Parent |
09479550 |
Jan 2000 |
US |
Child |
09642630 |
Aug 2000 |
US |
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
08635179 |
Apr 1996 |
US |
Child |
08842454 |
Apr 1997 |
US |