Method for the prophylaxis and/or treatment of proliferative and/or inflammatory skin disorders

Abstract

The present invention relates generally to a method for the prophylaxis and/or treatment of skin disorders, and in particular proliferative and/or inflammatory skin disorders, and to genetic molecules useful for same. The present invention is particularly directed to genetic molecules capable of modulating growth factor interaction with its receptor on epidermal keratinocytes to inhibit, reduce or otherwise decrease stimulation of this layer of cells. The present invention contemplates, in a most preferred embodiment, a method for the prophylaxis and/or treatment of psoriasis.

Description

[0001] The present invention relates generally to a method for the prophylaxis and/or treatment of skin disorders, and in particular proliferative and/or inflammatory skin disorders, and to genetic molecules useful for same. The present invention is particularly directed to genetic molecules capable of modulating growth factor interaction with its receptor on epidermal keratinocytes to inhibit, reduce or otherwise decrease stimulation of this layer of cells. The present invention contemplates, in a most preferred embodiment, a method for the prophylaxis and/or treatment of psoriasis.

[0002] Bibliographic details of the publications numerically referred to in this specification are collected at the end of the description. Sequence Identity Numbers (SEQ ID NOs.) for the nucleotide sequences referred to in the specification are defined following the bibliography.

[0003] Throughout this specification, unless the context requires otherwise, the word “comprise”, or variations such as “comprises” or “comprising”, will be understood to imply the inclusion of a stated element or integer or group of elements or integers but not the exclusion of any other element or integer or group of elements or integers.

[0004] Psoriasis and other similar conditions are common and often distressing proliferative and/or inflammatory skin disorders affecting or having the potential to affect a significant proportion of the population. The condition arises from over proliferation of basal keratinocytes in the epidermal layer of the skin associated with inflammation in the underlying dermis. Whilst a range of treatments have been developed, none is completely effective and free of adverse side effects. Although the underlying cause of psoriasis remains elusive, there is some consensus of opinion that the condition arises at least in part from over expression of local growth factors and their interaction with their receptors supporting keratinocyte proliferation via keratinocyte receptors which appear to be more abundant during psoriasis.

[0005] One important group of growth factors are the dermally-derived insulin-like growth factors (IGFs) which support keratinocyte proliferation. In particular, IGF-I and IGF-II are ubiquitous peptides each with potent mitogenic effects on a broad range of cells. Molecules of the IGF type are also known as “progression factors” promoting “competent” cells through DNA synthesis. The IGFs act through a common receptor known as the Type I or IGF-I receptor, which is tyrosine kinase linked. They are synthesised in mesenchymal tissues, including the dermis, and act on adjacent cells of mesodermal, endodermal or ectodermal origin. The regulation of their synthesis involves growth hormone (GH) in the liver, but is poorly defined in most tissues (1).

[0006] Particular proteins, referred to as IGF binding proteins (IGFBPs), appear to be involved in autocrine/paracrine regulation of tissue IGF availability (2). Six IGFBPs have so far been identified. The exact effects of the IGFBPs is not clear and observed effects in vitro have been inhibitory or stimulatory depending on the experimental method employed (3). There is some evidence, however, that certain IGFBPs are involved in targeting IGF-I to its cell surface receptor.

[0007] Skin, comprising epidermis and underlying dermis, has GH receptors on dermal fiboblasts (4). Fibroblasts synthesize IGF-I as well as IGFBPs-3, -4, -5 and -6 (5) which may be involved in targeting IGF-I to adjacent cells as well as to the overlaying epidermis. The major epidermal cell type, the keratinocyte, does not synthesize IGF-I, but possesses IGF-I receptors and is responsive to IGF-I (6).

[0008] It is apparent, therefore, that IGF-I and other growth promoting molecules, are responsible for or at least participate in a range of skin cell activities. In accordance with the present invention, the inventors have established that abberations in the normal functioning of these molecules or abberations in their interaction with their receptors is an important factor in proliferative and/or inflammatory skin disorders. It is proposed, therefore, to target these molecules or other molecules which facilitate their functioning or interaction with their receptors to thereby ameliorate the effects of abberant activity during or leading to skin disease conditions.

[0009] Accordingly, one aspect of the present invention contemplates a method for ameliorating the effects of a proliferative and/or inflammatory skin disorder in a mammal, said method comprising contacting the proliferating and/or inflamed skin or skin capable of proliferation and/or inflammation with an effective amount of a nucleic acid molecule or chemical analogue thereof capable of inhibiting or otherwise reducing a growth factor mediated cell proliferation and/or inflammation. Growth factor mediated cell proliferation and inflammation are also referred to as epidermal hyperplasias and may be mediated by any number of molecules such as but not limited to IGF-I, keratinocyte growth factor (KGF), transforming growth factor-α (TGFα), tumour necrosis factor-α (TNFα), interleukin-1, -4, -6 and 8 (IL-1, IL-4, IL-6 and IL-8, respectively), basic fibroblast growth factor (bFGF) or a combination of one or more of the above. The present invention is particularly described and exemplified with reference to IGF-I and its receptor (IGF-I receptor) and to IGF-I facilitating molecules, IGFBPs, since targeting these molecules according to the methods contemplated herein provides the best results to date. This is done, however, with the understanding that the present invention extends to any growth factor or cytokine-like molecule, a receptor thereof or a facilitating molecule like the IGFBPs involved in skin cell proliferation such as those molecules contemplated above and/or their receptors and/or facilitating molecules therefor.

[0010] According to this preferred embodiment, there is provided a method for ameliorating the effects of a proliferative and/or inflammatory skin disorder in a mammal, said method comprising contacting the proliferating and/or inflamed skin or skin capable of proliferation and/or inflammation with an effective amount of a nucleic acid molecule or chemical analogue thereof capable of inhibiting or otherwise reducing IGF-I mediated cell proliferation and/or inflammation.

[0011] The present invention is particularly described by psoriasis as the proliferative skin disorder. However, the subject invention extends to a range of proliferative and/or inflammatory skin disorders or epidermal hyperplasias such as but not limited to psoriasis, ichthyosis, pityriasis rubra pilaris (“PRP”), seborrhoea, keloids, keratoses, neoplasias and scleroderma, warts, benign growths and cancers of the skin.

[0012] In a preferred embodiment, therefore, the present invention is directed to a method for ameliorating the effects of psoriasis, said method comprising contacting proliferating skin or skin capable of proliferation with an effective amount of a nucleic acid molecule or chemical analogue thereof capable of inhibiting or otherwise reducing IGF-I mediated cell proliferation.

[0013] The present invention extends to any mammal such as but not limited to humans, livestock animals (e.g. horses, sheep, cows, goats, pigs, donkeys), laboratory test animals (e.g. rabbits, mice, guinea pigs), companion animals (e.g. cats, dogs) and captive wild animals. However, the instant invention is particularly directed to proliferative and/or inflammatory skin disorders such as psoriasis in humans.

[0014] The aspects of the subject invention instantly contemplated are particularly directed to the topical application of one or more suitable nucleic molecules capable of inhibiting, reducing or otherwise interfering with IGF-mediated cell proliferation and/or inflammation. More particularly, the nucleic acid molecule targets IGF-I interaction with its receptor. Conveniently, therefore, the nucleic acid molecule is an antagonist of IGF-I interaction with its receptor. Most conveniently, the nucleic acid molecule antagonist is an antisense molecule to the IGF-I receptor, to IGF-I itself or to a molecule capable of facilitating IGF-I interaction with its receptor such as but not limited to an IGFBP.

[0015] Insofar as the invention relates to IGFBPs, the preferred molecules are IGFBP-2, -3, -4, -5 and -6. The most preferred molecules are IGFBP-2 and IGFBP-3.

[0016] The nucleotide sequences of IGFBP-2 and IGFBP-3 are set forth in FIGS. 1 (SEQ ID NO. 1) and 2 (SEQ ID NO. 2), respectively. According to a particularly preferred aspect of the present invention, there is provided a nucleic acid molecule comprising at least about ten nucleotides capable of hybridising to, forming a heterodouplex or otherwise interacting with an mRNA molecule directed from a gene corresponding to a genomic form of SEQ ID NO. 1 and/or SEQ ID NO. 2 and which thereby reduces or inhibits translation of said mRNA molecule. Preferably, the nucleic acid molecule is at least about 15 nucleotides in length and more preferably at least about 20-25 nucleotides in length. However, the instant invention extends to any length nucleic acid molecule including a molecule of 100-200 nucleotides in length to correspond to the full length of or near full length of the subject genes.

[0017] The nucleotide sequence of the antisense molecules may correspond exactly to a region or portion of SEQ ID NO. 1 or SEQ ID NO. 2 or may differ by one or more nucleotide substitutions, deletions and/or additions. It is a requirement, however, that the nucleic acid molecule interact with an mRNA molecule to thereby reduce its translation into active protein.

[0018] Examples of potential antisense molecules for IGFBP-2 and IGFBP-3 are those capable of interacting with sequences selected from the lists in Examples 6 and 7, respectively.

[0019] The nucleic acid molecules in the form of an antisense molecule may be linear or covalently closed circular and single stranded or partially double stranded. A double stranded molecule may form a triplex with target mRNA or a target gene. The molecule may also be protected from, for example, nucleases, by any number of means such as using a nonionic backbone or a phosphorothioate linkage. A convenient nonionic backbone contemplated herein is ethylphosphotriester linkage or a 2′-O-methylribosyl derivative.

[0020] Examples of suitable oligonucleotide analogues are conveniently described in Ts'O et al (7).

[0021] Alternatively, the antisense molecules of the present invention may target the IGF-I gene itself or its receptor or a multivalent antisense molecule may be constructed or separate molecules administered which target at least two or an IGFBP, IGF-I and/or IGF-I-receptor. Examples of suitable antisense molecules capable of targetting the IGF-I receptor are those capable of interacting with sequences selected from the list in Example 8. One particularly useful antisense molecule is 5′-ATCTCTCCGCTTCCTTTC-3′ (SEQ ID NO. 10). A particularly preferred embodiment of the present invention contemplates a method of ameliorating the effects of psoriasis, said method comprising contacting proliferating skin or skin capable of proliferation with an effective amount of one or more nucleic acid molecules or chemical analogues thereof capable of inhibiting or otherwise reducing IGF-I mediated cell proliferation wherein said one or more molecules comprises a polynucleotide capable of interacting with mRNA directed from two or more of an IGF-I gene, an IGF-I receptor gene or a gene encoding an IGFBP such as IGFBP-2 and/or IGFBP-3.

[0022] In accordance with one aspect of the present invention the nucleic acid molecule is topically applied in aqueous solution or in conjunction with a cream, ointment, oil or other suitable carrier and/or diluent. A single application may be sufficient depending on the severity or exigencies of the condition although more commonly, multiple applications are required ranging from hourly, multi-hourly, daily, multi-daily, weekly or monthly, or in some other suitable time interval. The treatment might comprise solely the application of the nucleic acid molecule or this may be applied in conjunction with other treatments for the skin proliferation and/or inflammatory disorder being treated or for other associated conditions including microbial infection, bleeding and the formation of a variety of rashes.

[0023] As an alternative to or in conjunction with antisense therapy, the subject invention extends to the nucleic acid molecule as, or incorporating, a ribozyme including a minizyme to, for example, IGF-I, its receptor or to molecules such as IGFBPs and in particular IGFBP-2 and -3. Ribozymes are synthetic nucleic acid molecules which possess highly specific endoribonuclease activity. In particular, they comprise a hybridising region which is complementary in nucleotide sequence to at least part of a target RNA. Ribozymes are well described by Haseloff and Gerlach (8) and in International Patent Application No. WO 89/05852. The present invention extends to ribozymes which target mRNA specified by genes encoding IGF-I, its receptor or one or more IGFBPs such as IGFBP-2 and/or IGFBP-3.

[0024] According to this embodiment, there is provided in a particularly preferred aspect a ribozyme comprising a hybridising region and a catalytic region wherein the hybridising region is capable of hybridising to at least part of a target mRNA sequence transcribed from a genomic gene corresponding to SEQ ID NO. 1 or SEQ ID NO. 2 wherein said catalytic domain is capable of cleaving said target mRNA sequence to reduce or inhibit IGF-I mediated cell proliferation and/or inflammation.

[0025] Yet another aspect of the present invention contemplates co-suppression to reduce expression or to inhibit translation of an endogenous gene encoding, for example, IGF-I, its receptor, or IGFBPs such as IGFBP-2 and/or -3. In co-suppression, a second copy of an endogenous gene or a substantially similar copy or analogue of an endogenous gene is introduced into a cell following topical administration. As with antisense molecules, nucleic acid molecules defining a ribozyme or nucleic acid molecules useful in co-suppression may first be protected such as by using a nonionic backbone.

[0026] The efficacy of the nucleic acid molecules of the present invention can be conveniently tested and screened using an in vitro system comprising a basal keratinocyte cell line. A particularly useful system comprises the HaCaT cell line described by Boukamp et al (9). In one assay, IGF-I is added to an oligonucleotide treated HaCaT cell line. Alternatively, growth of oligonucleotide treated HaCaT cells is observed on a feeder layer of irradiated 3T3 fibroblasts. Using such in vitro assays, it is observed that antisense oligonucleotides to IGFBP-3, for example, inhibit production of IGFBP-3 by HaCaT cells. Other suitable animal models include the nude mouse/human skin graft model (15; 16) and the “flaky skin” mouse model (17; 18). In the nude mouse model, microdermatome biopsies of psoriasis lesions are taken under local anaesthetic from volunteers then transplanted to congenital athymic (nude) mice. These transplanted human skin grafts maintain the characteristic hyperproliferating epidermis for 6-8 weeks. They are an established model for testing the efficacy of topically applied therapies for psoriasis. In the “flaky skin” mouse model, the fsn/fsn mutation produces mice with skin resembling human psoriasis. This mouse, or another mutant mouse with a similar phenotype is a further in vivo model to test the efficacy of topically applied therapies for psoriasis.

[0027] Another aspect of the present invention contemplates a pharmaceutical composition for topical administration which comprises a nucleic acid molecule capable of inhibiting or otherwise reducing IGF-I mediated cell proliferation such as psoriasis and one or more pharmaceutically acceptable carriers and/or diluents. Preferably, the nucleic acid molecule is an antisense molecule to IGF-I, the IGF-I receptor or an IGFBP such as IGFBP-2 and/or IGFBP-3 or comprises a ribozyme to one or more of these targets or is a molecule suitable for co-suppression of one or more of these targets. The composition may comprise a single species of a nuleic acid molecule capable of targeting one of IGF-I, its receptor or an IGFBP, such as IGFBP-2 or IGFBP-3 or may be a multi-valent molecule capable of targeting two or more of IGF-I, its receptor or an IGFBP, such as IGFBP-2 and/or IGFBP-3.

[0028] The nucleic acid molecules may be administered in dispersions prepared in creams, ointments, oil or other suitable carrier and/or diluent such as glycerol, liquid polyethylene glycols and/or mixtures thereof. Under ordinary conditions of storage and use, these preparations may contain a preservative to prevent the growth of microorganisms.

[0029] The pharmaceutical forms suitable for topical use include sterile aqueous solutions (where water soluble) or dispersions and powders for the extemporaneous preparation of topical solutions or dispersion. In all cases, the form is preferably sterile although this is not an absolute requirement and is stable under the conditions of manufacture and storage. The carrier can be a solvent or dispersion medium containing, for example, water, ethanol, polyol (for example, glycerol, propylene glycol, and liquid polyethylene glycol, and the like), suitable mixtures thereof and vegetable oils. The proper fluidity can be maintained, for example, by the use of a coating such as lecithin, by the maintenance of the required particle size in the case of dispersion and by the use of superfactants. The prevention of the action of microorganism can be brought about by various antibacterial and antifungal agents, for example, parabens, chlorobutanol, phenol, sorbic acid, thirmerosal and the like. In many cases, it will be preferable to include isotonic agents, for example, sugars or sodium chloride.

[0030] Topical solutions arc prepared by incorporating the nucleic acid molecule compound in the required amount in the appropriate solvent with various of the other ingredients enumerated above, as required, followed by where necessary filter sterilization.

[0031] As used herein “pharmaceutically acceptable carriers and/or diluents” include any and all solvents, dispersion media, aqueous solutions, coatings, antibacterial and antifungal agents, isotonic and absorption delaying agents, and the like. The use of such media and agents for pharmaceutical active substances is well known in the art. Except insofar as any conventional media or agent is incompatable with the active ingredient, use thereof in the pharmaceutical compositions is contemplated. Supplementary active ingredients can also be incorporated into the compositions. Conveniently, the nucleic acid molecules of the present invention are stored in freeze-dried form and are reconstituted prior to use.

[0032] Yet another aspect of the present invention contemplates the use of a nucleic acid molecule in the manufacture of a medicament for the treatment of proliferative and/or inflammatory skin disorders mediated by a growth factor. The proliferative and/or inflammatory skin disorder is generally psoriasis and the nucleic acid molecule targets IGF-I, the IGF-I receptor and/or an IGFBP such as IGFBP-2 and/or IGFBP-3.

[0033] Still a further aspect of the present invention contemplates an agent comprising a nucleic acid molecule as hereinbefore defined useful in the treatment of proliferative and/or inflammatory skin disorders, such as psoriasis.

[0034] The present invention is further described by the following non-limiting Figures and/or Examples.

[0035] In the Figures:

[0036] FIG. 1 is a representation of the nucleotide sequence of IGFBP-2.

LOCUS      HSIGFBP2   1433 bp  RNA     PRI    31-JAN-1990
DEFINITION Human mRNA for insulin-like growth factor binding protein (IGFBP-2)
ACCESSION  X16302
KEYWORDS   insulin-like growth factor binding protein.
SOURCE     human
           ORGANISM     Homo sapiens
                        Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
                        Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE  1 (bases 1 to 1433)
           AUTHORS      Binkert,C., Landwehr,J., Mary,J.L., Schwander,J. and Heinrich,G.
           TITLE        Cloning, sequence analysis and expression of a cDNA encoding a
                        novel insulin-like growth factor binding protein (IGFBP-2)
           JOURNAL      EMBO J. 8, 2497-2502 (1989)
           STANDARD     full automatic
COMMENT    NCBI gi: 33009
FEATURES   Location/Qualifiers
           source       1. .1433
                        /organism=“Homo sapiens”
                        /dev_stage=“fetal”
                        /tissue_type=“liver”
           misc_feature 1416. .1420
                        /note=“pot. polyadenylation signal”
           polyA_site   1433
                        /note=“polyadenylation site”
           CDS          118. .1104
                        /note=“precursor polypeptide; (AA -39 to 289); NCBI gi:
                        33010.”
                        /codon_start=1
                        /translation=“MLPRVGCPALPLPPPPLLPLLPLLLLLLGASGGGGGARAEVLFR
                        CPPCTPERLAACGPPPVAPPAAVAAVAGGARMPCAELVREPGCGCCSVCARLEGEACG
                        VYTPRCGQGLRCYPHPGSELPLQALVMGEGTCEKRRDAEYGASPEQVADNGDDHSEGG
                        LVENHVDSTMNMLGGGGSAGRKPLKSGMKELAVFREKVTEQHRQMGKGGKHHLGLEEP
                        KKLRPPPARTPCQQELDQVLERISTMRLPDERGPLEHLYSLHIPNCDKHGLYNLKQCK
                        MSLNGQRGECWCVNPNTGKLIQGAPTIRGDPECHLFYNEQQEACGVHTQRMQ”
           CDS          118. .234
                        /note=“signal peptide; (AA -39 to -1); NCBI gi: 33011.”
                        /codon_start=1
                        /translation=“MLPRVGCPALPLPPPPLLPLLPLLLLLLGASGGGGGARA”
           CDS          235. .1101
                        /note=“mature IGFBP-2; (AA 1 to 289); NCBI gi: 33012.”
                        /codon_start=1
                        /translation=“EVLFRCPPCTPERLAACGPPPVAPPAAVAAVAGGARMPCAELVR
                        EPGCGCCSVCARLEGEACGVYTPRCGQGLRCYPHPGSELPLQALVMGEGTCEKRRDAE
                        YGASPEQVADNGDDHSEGGLVENHVDSTMNMLGGGGSAGRKPLKSGMKELAVFREKVT
                        EQHRQMGKGGKHHKGLEEPKKLRPPPARTPCQQELDQVLERISTMRLPDERGPLEHLY
                        SLHIPNCDKEGLYNLKQCKMSLNGQRGECWCVNPNTGKLIQGAPTIRGDPECHLFYNE
                        QQEACGVHTQRMQ”
BASE COUNT   239 a   466 c   501 g   227 t
ORIGIN
HSIGFBP2 Length:  1433 May 11, 1994 10:06 Type: N Check: 6232 ..

[0037] FIG. 2 is a representation of the nucleotide sequence of IGFBP-3.

LOCUS      HUMGFIBPA   2474 bp ss-mRNA     PRI    15-JUN-1990
DEFINITION Human growth hormone-dependent insulin-like growth factor-binding
           protein mRNA, complete cds.
ACCESSION  M31159
KEYWORDS   insulin-like growth factor binding protein.
SOURCE     Human plasma, eDNA to mRNA, clone BP-53.
           ORGANISM Homo sapiens
                    Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria;
                    Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE  1 (bases 1 to 2474)
           AUTHORS  Wood,W.I., Cachianes,G., Henzel,W.J., Winslow,G.A., Spencer,S.A.,
                    Hellmiss,R., Martin,J.L. and Baxter,R.C.
           TITLE    Cloning and expression of the growth hormone-dependent insulin-like
                    growth factor-binding protein
           JOURNAL  Mol. Endocrinol. 2, 1176-1185 (1988)
           STANDARD full automatic
COMMENT    NCBI gi: 183115
FEATURES   Location/Qualifiers
           mRNA     <1. .2474
                    /note=“GFIBP mRNA”
           CDS      110. .985
                    /gene=“IGFBP1”
                    /note=“insulin-like growth factor-binding protein; NCBI
                    gi: 183116.”
                    /codon_start=1
                    /translation=“MQRARPTLWAAALTLLVLLRGPPVARAGASSGGLGPVVRCEPCD
                    ARALAQCAPPPAVCAELVREPGCGCCLTCALSEGQPCGIYTERCGSGLRCQPSPDEAR
                    PLQALLDGRGLCVNASAVSRLAYLLJPAPPAPGNASESEEDRSAGSVESPSVSSTHRV
                    SDPKFWPLHSKIIIIKKGHAKDSQRYKDYESQSTDTQNFSSESKRETEYGPCRREME
                    DTLNHLKFLNVLSPRGHIPNCDKKGFYKKKKQCRPSKGRKRGFCWCVCDKYGQPLPGYT
                    TKGKEDVHCYSMQSK”
           source   1. .2474
                    /organism=“Homo sapiens”
BASE COUNT   597 a   646 c   651 g   580 t
ORIGIN
HUMGFIBPA Length: 2474 May 11, 1994 10:00 Type: N Check: 9946 ..

[0038] FIG. 3 is a representation of the nucleotide sequence of IGF-l-receptor.

LOCUS      HSIGFIRR   4989 bp  RNA     PRI    28-MAR-1991
DEFINITION Human mRNA for insulin-like growth factor I receptor
ACCESSION  X04434 M24599
KEYWORDS   glycoprotein; insulin receptor;
           insulin-like growth factor I receptor; membrane glycoprotein;
           receptor; tyrosine kinase.
SOURCE     human
           ORGANISM     Homo sapiens
                        Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
                        Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE  1 (bases 1 to 4989)
           AUTHORS      Ullrich,A., Gray,A., Tam,A.W., Yang-Feng,T., Tsubokawa,M.,
                        Collins,C., Henzel,W., Bon,T.L., Kathuria,S., Chen,E., Jakobs,S.,
                        Francke , U., Ramachandran, J. and Fujita-Yamaguchi, Y.
           TITLE        Insulin-like growth factor I receptor primary structure: comparison
                        with insulin receptor suggests structural dererminants that define
                        functional specificity
           JOURNAL      EMBO J. 5, 2503-2512 (1986)
           STANDARD     full automatic
COMMENT    NCBI gi: 33058
FEATURES   Location/Qualifiers
           source       1. .4989
                        /organism=“Homo sapiens”
                        /tissue_type=“placenta”
                        /clone—lib=“ (lamda)gt10”
                        /clone=“ (lambda) IGF-1-R.85, (lambda) IGF-1-R.76”
           sig_peptide  32. .121
           mat_peptide  122. .4132
                        /note=“IGF-I receptor”
           misc_feature 122. .2251
                        /note=“alpha-subunit (AA 1 - 710)”
           misc_feature 182. .190
                        /note=“pot.N-linked glycosylation site (AA 21 - 23)”
           misc_feature 335. .343
                        /note=“pot.N-linked glycostlation site (AA 72 - 74)”
           misc_feature 434. .442
                        /note=“pot.N-linked glycostlation site (AA 105 - 107)”
           misc_feature 761. .769
                        /note=“pot.N-linked glycostlation site (AA 214 - 216)”
           misc_feature 971. .979
                        /note=“pot.N-linked glycostlation site (AA 284 - 286)”
           misc feature 1280. .1288
                        /note=“pot.N-linked glycostlation site (AA 387 - 389)”
           misc_feature 1343. .1351
                        /note=“pot.N-linked glycosylation site (AA 408 - 410)”
           misc_feature 1631. .1639
                        /note=“pot.N-linked glycostlation site (AA 504 - 506)”
           misc_feature 1850. .1858
                        /note=“pot.N-linked glycosylation site (AA 577 - 579)”
           misc feature 1895. .1903
                        /note.“pot.N-linked glycosylation site (AA 592 - 594)”
           misc_feature 1949. .1957
                        /note=“pot.N- linked glycosylation site (AA 610 - 612)”
           misc_feature 2240. .2251
                        /note=“putative proreceptor processing site (AA 707 -
                        710)”
           misc_feature 2252. .4132
                        /note=“beta-subunit (AA 711 - 1337)”
           misc_feature 2270. .2278
                        /note=“pot.N-linked glycosylation site (AA 717 - 719]”
           misc_feature 2297. .2305
                        /note=“pot.N-linked glycosylation site (AA 726 - 728)”
           misc feature 2321. .2329
                        /note=“pot.N-linked glycosylation site (AA 734 - 736)”
           misc_feature 2729. .2737
                        /note=“pot.N-linked glycosylation site (AA 870 - 872)”
           misc feature 2768. .2776
                        /note=“pot.N-linked glycosylation site (AA 883 - 885)”
           misc_feature 2837. .2908
                        /note=“transmembrane region (AA 906 - 929)”
           misc feature 2918. .2926
                        /note=“pot.N-linked glycosylation site (AA 933 - 935)”
           misc_feature 3047. .3049
                        /note=“pot.ATP binding site (AA 976)”
           misc feature 3053. .3055
                        /note=“pot.ATP binding site (AA 978)”
           misc feature 3062. .3064
                        /note=“pot.ATP binding site (AA 981)”
           misc_feature 3128. .3130
                        /note=“pot.ATP binding site (AA 1003)”
           CDS          32. .4132
                        /product=“IGF-I receptor”
                        /note=“50 stops when translation attempted, frame 1, code
                        0”
BASE COUNT   1216 a   1371 c   1320 g   1082 t
ORIGIN
HSIGFIRR Length: 4989 May 11, 1994 12:10 Type: N Check: 133 ..

[0039] FIG. 4A is a photographic representation of a Western ligand blot of HaCaT conditioned medium showing IGFBP-3 secreted in 24 hours after 7 day treatment with phosphorothioate oligonucleotides (BP3AS2, BP3AS3 and BP3S) at 0.5 μM and 5 μM; * no oligonucleotide added.

[0040] FIG. 4B is a graphical representation of a scanning imaging desitometry of Western ligand blot (FIG. 4A), showing relative band intensities of IGFBP-3 and the 24 kDa IGFBP-4 after treatment with phosphorothioate oligonucleotides; * no oligonucleotide added.

[0041] FIG. 5A is a photographic representation of a Western ligand blot of HaCaT conditioned medium showing IGFBP-3 secreted in 24 hours after 7 day treatment with phosophorothioate oligonucleotide BP3AS2 at 0.5 μM compared with several control oligonucleotides at 0.5 μM. (a) oligonucleotide BP3AS2NS; (b) oligonucleotide BP3AS4; (c) oligonucleotide BP3AS4NS; and (untreated), no oligonucleotide added.

[0042] FIG. 5B is a graphical representation of a scanning imaging densitometry of Western ligand blot (FIG. 5A), showing relative band intensities of IGFBP-3 after treatment with phosphorothioate oligonucleotides as in FIG. 5A, showing IGFBP-3 band intensities expressed as a percentage of the average band intensity from conditioned medium of cells not treated with oligonucleotide.

[0043] FIG. 6 is a graphical representation showing inhibition of IGF-I binding by antisense oligonucleotides to IGF-I receptor. IGFR.AS: antisense; IGFR.S: sense.

[0044] FIG. 7 is a graphical representation showing inhibition of IGFBP-3 production in culture medium following initial treatment with antisense oligonucleotides once daily over a 2 day period.

[0045] FIG. 8 is a graphical representation showing optimization of IGFBP-3 antisense oligonucleotide concentration as determined by relative IGFBP-3 concentration in culture medium.

EXAMPLE 1

In Vitro Assay

[0046] Cells

[0047] The differentiated human keratinocyte cell line, HaCaT (9) was used in the in vitro assay. Cells at passage numbers 33 to 36 were maintained as monolayer cultures in 5% v/v CO2 at 37° C. in Keratinocyte-SFM (Gibco) containing EGF and bovine pituitary extract as supplied. Media containing foetal calf serum were avoided because of the high content of IGF-I binding proteins in serum.

[0048] Feeder layer plates of lethally irradiated 3T3 fibroblasts were prepared exactly as described by Rheinwald and Green (10).

EXAMPLE 2

In Vitro Assay

[0049] Thymidine Incorporation Assay

[0050] Cells were grown to 4 days post confluence in 2 cm2 wells with daily medium changes of Keratinocyte-SFM, then the medium was changed to DMEM (Cytosystems, Australia), with the following additions: 25 mM Hepes, 0.19% w/v, sodium bicarbonate, 0.03% w/v glutamine (Sigma Chemical Co, USA), 50 IU/ml penicillin and 50 μg/ml streptomycin (Flow Laboratories). After 24 hours, IGF-I or tIGF-I was added to triplicate wells, at the concentrations indicated, in 0.5 ml fresh DMEM containing 0.02% v/v bovine serum albumin (Sigma molecular biology grade) and incubated for a further 21 hours. [3H]-Thymidine (0.1 μCi/well) was then added and the cells incubated for a further 3 hours. The medium was then aspirated and the cells washed once with ice-cold PBS and twice with ice-cold 10% v/v TCA. The TCA-precipitated monolayers were then solubilized with 0.25M NaOH (200 μl/well), transferred to scintillation vials and radioactivity determined by liquid scintillation counting (Pharmacia Wallac 1410 liquid scintillation counter).

EXAMPLE 3

Western Ligand Blotting

[0051] HaCaT conditioned medium (250 μl) was concentrated by adding 750 μl cold ethanol, incubating at −20° C. for 2 hours and centrifuging at 16,000 g for 20 min at 4° C. The resulting pellet was air dried, resuspended thoroughly in non-reducing Laemmli sample buffer, heated to 90° C. for 5 minutes and separated on 12% w/v SDS-PAGE according to the method of Laemmli (1970). Separated proteins were electrophoretically transferred to nitrocellulose membrane (0.45 mm, Schleicher and Schuell, Dassel, Germany) in a buffer containing 25 mM Tris, 192 mM glycine and 20% v/v methanol. IGFBPs were then visualised by the procedure of Hossenlopp et al (11), using [125I]-IGF-I, followed by autoradiography. Autoradiographs were scanned in a BioRad Model GS-670 Imaging Densitometer and band densities were determined using the Molecular Analyst program.

EXAMPLE 4

Antisense Oligonucleotides

[0052] Phosphorothioate oligodeoxynucleotides were synthesised by Bresatec, Adelaide, South Australia, Australia. The following antisense sequences were used: BP3AS2, 5′-GCG CCC GCT GCA TGA CGC CTG CAA C-3′ (SEQ ID NO. 4), a 25mer complementary to the start codon region of the human IGFBP-3 mRNA; BP3AS3, 5′-CGG GCG GCT CAC CTG GAG CTG GCG-3′ (SEQ ID NO. 5), a 24 mer complementary to the exon 1/intron 1 splice site; BP3AS4, 5′-AGG CGG CTG ACG GCA CTA-3′ (SEQ ID NO. 6), an 18 mer complementary to a region of the coding sequence lacking RNA secondary structure and oligonucleotide-dimer formation (using the computer software “OLIGO for PC”). Since BP3AS4 was found to be ineffective at inhibiting IGFBP-3 synthesis, it was used as a control. The following additional control oligonucleotide sequences were used: BP3S, 5′-CAG GCG TCA TGC AGC GGG C-3′ (SEQ ID NO. 7), an 18 mer sense control sequence equivalent to the start codon region; BP3AS2NS, 5′-CGG AGA TGC CGC ATG CCA GCG CAG G-3′ (SEQ ID NO. 8), a 25 mer randomised sequence with the same GC content as BP3AS2; BP3AS4NS, 5′-GAC AGC GTC GGA GCG ATC-3′ (SEQ ID NO. 9), an 18 mer randomised sequence with the same GC content as BP3AS4NS. Design of the oligonucleotides was based on the human IGFBP-3 cDNA sequence of Spratt et al (12).

[0053] Cells were grown to one day post confluence in 2 cm2 wells with daily medium changes of 0.5 ml Keratinocyte-SFM, then subjected to daily medium changes of Keratinocyte-SFM for a further 4 days. Daily additions of 0.5 ml fresh Keratinocyte-SFM were then continued for a further 7 days, except that at the time of medium addition, 5 μl oligonucleotide in PBS was added to give the final concentrations indicated, then the wells were shaken to mix the oligonucleotide. After the final addition, cells were incubated for 24 hours and the medium collected for assay of IGFBPs. Cells were then counted after trypsinisation in a Coulter Industrial D Counter, Coulter Bedfordshire, UK. Cell numbers after oligonucleotide treatment differed by less than 10%.

EXAMPLE5

Antisense Oligonucleotides Inhibit IGFBP-3 Synthesis

[0054] HaCaT cells secrete mainly IGFBP-3 (>95%), with the only other IGFBP detectable in HaCaT conditioned medium being IGFBP-4 (<5%). The effect on IGFBP-3 and IGFBP-4 synthesis of antisense oligonucleotides at two concentrations, 5 μM and 0.5 μM, was tested. Two oligonucleotides were used, BP3AS2 and BP3AS3, directed against the start site and the intron 1/exon 1 splice site, respectively of the IGFBP-3 mRNA. As a control, a sense oligonucleotide corresponding to the start site was used. As shown in FIGS. 4A and 4B, all oligonucleotides at 5 μM caused a significant reduction of IGFBP-3 synthesis compared with untreated cells, however, the two antisense oligonucleotides inhibited IGFBP-3 synthesis of approximately 50% compared to the sense control (FIG. 4B). The antisense oligonucleotide directed to the start codon appeared to be more effective of the two, the difference being more apparent at the lower concentration of 0.5 μM. The cells of IGFBP4 secreted by the HaCaT cells make photographic reproduction of the bands on Western ligand blots difficult, however densitometry measurements provide adequate relative quantitation. This resulted in the significant observation that IGFBP4 levels were unaffected by oligonucleotide addition to the cells, suggesting that the observed inhibitory effects on IGFBP-3 are specific.

[0055] To further investigate the inhibitory effects of the more effective of the two antisense oligonucleotides, BP3AS2, inhibition by this oligonucleotide at 0.5 μM was compared with a number of control oligonucleotides, including one antisense oligonucleotide to IGFBP-3 that had proved to be ineffective at 0.5 μM. As shown in FIGS. 5A and 5B, BP3AS2 was again inhibitory, resulting in levels of IGFBP-3 of approximately 50% of the most non-specifically inhibitory control oligonucleotide, the randomised equivalent of BP3AS2. The other control oligonucleotides caused no reduction in IGFBP-3 levels at 0.5 μM, compared to untreated cells. Of possible significance is the fact that this control oligonucleotide, BP3AS2NS, like BP3AS2 itself, has the highest potential Tm of the three control oligonucleotides used in this experiment, enhancing the probability of non-specific base pairing with ron-target mRNAs. However, the lack of inhibition of IGFBP4 secretion by BP3AS2 suggests that this oligonucleotide is selective even compared with the most closely related protein likely to be present in this cell line.

EXAMPLE 6

Antisense Oligonucleotides of IGFBP2

[0056] Antisense oligonucleotides to IGFBP2 may be selected from molecules capable of interacting with one or more of the following sense oligonucleotides:

ATTCGGGGCGAGGGA	AAGAAGCGGAGGAGG	CCCGCTCGCAGGGCC
TTCGGGGCGAGGGAG	AGAAGCGGAGGAGGC	CCGCTCGCAGGGCCG
TCGGGGCGAGGGAGG	GAAGCGGAGGAGGCG	CGCTCGCAGGGCCGT
CGGGGCGAGGGAGGA	AAGCGGAGGAGGCGG	GCTCGCAGGGCCGTG
GGGGCGAGGGAGGAG	AGCGGAGGAGGCGGC	CTCGCAGGGCCGTGC
GGGCGAGGGAGGAGG	GCGGAGGAGGCGGCT	TCGCAGGGCCGTGCA
GGCGAGGGAGGAGGA	CGGAGGAGGCGGCTC	CGCAGGGCCGTGCAC
GCGAGGGAGGAGGAA	GGAGGAGGCGGCTCC	GCAGGGCCGTGCACC
CGAGGGAGGAGGAAG	GAGGAGGCGGCTCCC	CAGGGCCGTGCACCT
GAGGGAGGAGGAAGA	AGGAGGCGGCTCCCG	AGGGCCGTGCACCTG
AGGGAGGAGGAAGAA	GGAGGCGGCTCCCGC	GGGCCGTGCACCTGC
GGGAGGAGGAAGAAG	GAGGCGGCTCCCGCT	GGCCGTGCACCTGCC
GGAGGAGGAAGAAGC	AGGCGGCTCCCGCTC	GCCGTGCACCTGCCC
GAGGAGGAAGAAGCG	GGCGGCTCCCGCTCG	CCGTGCACCTGCCCG
AGGAGGAAGAAGCGG	GCGGCTCCCGCTCGC	CGTGCACCTGCCCGC
GGAGGAAGAAGCGGA	CGGCTCCCGCTCGCA	GTGCACCTGCCCGCC
GAGGAAGAAGCGGAG	GGCTCCCGCTCGCAG	TGCACCTGCCCGCCC
AGGAAGAAGCGGAGG	GCTCCCGCTCGCAGG	GCACCTGCCCGCCCG
GGAAGAAGCGGAGGA	CTCCCGCTCGCAGGG	CACCTGCCCGCCCGC
GAAGAAGCGGAGGAG	TCCCGCTCGCAGGGC	ACCTGCCCGCCCGCC
CCTGCCCGCCCGCCC	CATGCTGCCGAGAGT	CGCTGCTGCCGCTGC
CTGCCCGCCCGCCCG	ATGCTGCCGAGAGTG	GCTGCTGCCGCTGCT
TGCCCGCCCGCCCGC	TGCTGCCGAGAGTGG	CTGCTGCCGCTGCTG
GCCCGCCCGCCCGCT	GCTGCCGAGAGTGGG	TGCTGCCGCTGCTGC
CCCGCCCGCCCGCTC	CTGCCGAGAGTGGGC	GCTGCCGCTGCTGCT
CCGCCCGCCCGCTCG	TGCCGAGAGTGGGCT	CTGCCGCTGCTGCTG
CGCCCGCCCGCTCGC	GCCGAGAGTGGGCTG	TGCCGCTGCTGCTGC
GCCCGCCCGCTCGCT	CCGAGAGTGGGCTGC	GCCGCTGCTGCTGCT
CCCGCCCGCTCGCTC	CGAGAGTGGGCTGCC	CCGCTGCTGCTGCTG
CCGCCCGCTCGCTCG	GAGAGTGGGCTGCCC	CGCTGCTGCTGCTGC
CGCCCGCTCGCTCGC	AGAGTGGGCTGCCCC	GCTGCTGCTGCTGCT
GCCCGCTCGCTCGCT	GAGTGGGCTGCCCCG	CTGCTGCTGCTGCTA
CCCGCTCGCTCGCTC	AGTGGGCTGCCCCGC	TGCTGCTGCTGCTAC
CCGCTCGCTCGCTCG	GTGGGCTGCCCCGCG	GCTGCTGCTGCTACT
CGCTCGCTCGCTCGC	TGGGCTGCCCCGCGC	CTGCTGCTGCTACTG
GCTCGCTCGCTCGCC	GGGCTGCCCCGCGCT	TGCTGCTGCTACTGG
CTCGCTCGCTCGCCC	GGCTGCCCCGCGCTG	GCTGCTGCTACTGGG
TCGCTCGCTCGCCCG	GCTGCCCCGCGCTGC	CTGCTGCTACTGGGC
CGCTCGCTCGCCCGC	CTGCCCCGCGCTGCC	TGCTGCTACTGGGCG
GCTCGCTCGCCCGCC	TGCCCCGCGCTGCCG	GCTGCTACTGGGCGC
CTCGCTCGCCCGCCG	GCCCCGCGCTGCCGC	CTGCTACTGGGCGCG
TCGCTCGCCCGCCGC	CCCCGCGCTGCCGCT	TGCTACTGGGCGCGA
CGCTCGCCCGCCGCG	CCCGCGCTGCCGCTG	GCTACTGGGCGCGAG
GCTCGCCCGCCGCGC	CCGCGCTGCCGCTGC	CTACTGGGCGCGAGT
CTCGCCCGCCGCGCC	CGCGCTGCCGCTGCC	TACTGGGCGCGAGTG
TCGCCCGCCGCGCCG	GCGCTGCCGCTGCCG	ACTGGGCGCGAGTGG
CGCCCGCCGCGCCGC	CGCTGCCGCTGCCGC	CTGGGCGCGAGTGGC
GCCCGCCGCGCCGCG	GCTGCCGCTGCCGCC	TGGGCGCGAGTGGCG
CCCGCCGCGCCGCGC	CTGCCGCTGCCGCCG	GGGCGCGAGTGGCGG
CCGCCGCGCCGCGCT	TGCCGCTGCCGCCGC	GGCGCGAGTGGCGGC
CGCCGCGCCGCGCTG	GCCGCTGCCGCCGCC	GCGCGAGTGGCGGCG
GCCGCGCCGCGCTGC	CCGCTGCCGCCGCCG	CGCGAGTGGCGGCGG
CCGCGCCGCGCTGCC	CGCTGCCGCCGCCGC	GCGAGTGGCGGCGGC
CGCGCCGCGCTGCCG	GCTGCCGCCGCCGCC	CGAGTGGCGGCGGCG
GCGCCGCGCTGCCGA	CTGCCGCCGCCGCCG	GAGTGGCGGCGGCGG
CGCCGCGCTGCCGAC	TGCCGCCGCCGCCGC	AGTGGCGGCGGCGGC
GCCGCGCTGCCGACC	GCCGCCGCCGCCGCT	GTGGCGGCGGCGGCG
CCGCGCTGCCGACCG	CCGCCGCCGCCGCTG	TGGCGGCGGCGGCGG
CGCGCTGCCGACCGC	CGCCGCCGCCGCTGC	GGCGGCGGCGGCGGG
GCGCTGCCGACCGCC	GCCGCCGCCGCTGCT	GCGGCGGCGGCGGGG
CGCTGCCGACCGCCA	CCGCCGCCGCTGCTG	CGGCGGCGGCGGGGC
GCTGCCGACCGCCAG	CGCCGCCGCTGCTGC	GGCGGCGGCGGGGCG
CTGCCGACCGCCAGC	GCCGCCGCTGCTGCC	GCGGCGGCGGGGCGC
TGCCGACCGCCAGCA	CCGCCGCTGCTGCCG	CGGCGGCGGGGCGCG
GCCGACCGCCAGCAT	CGCCGCTGCTGCCGC	GGCGGCGGGGCGCGC
CCGACCGCCAGCATG	GCCGCTGCTGCCGCT	GCGGCGGGGCGCGCG
CGACCGCCAGCATGC	CCGCTGCTGCCGCTG	CGGCGGGGCGCGCGC
GACCGCCAGCATGCT	CGCTGCTGCCGCTGC	GGCGGGGCGCGCGCG
ACCGCCAGCATGCTG	GCTGCTGCCGCTGCT	GCGGGGCGCGCGCGG
CCGCCAGCATGCTGC	CTGCTGCCGCTGCTG	CGGGGCGCGCGCGGA
CGCCAGCATGCTGCC	TGCTGCCGCTGCTGC	GGGGCGCGCGCGGAG
GCCAGCATGCTGCCG	GCTGCCGCTGCTGCC	GGGCGCGCGCGGAGG
CCAGCATGCTGCCGA	CTGCCGCTGCTGCCG	GGCGCGCGCGGAGGT
CAGCATGCTGCCGAG	TGCCGCTGCTGCCGC	GCGCGCGCGGAGGTG
AGCATGCTGCCGAGA	GCCGCTGCTGCCGCT	CGCGCGCGGAGGTGC
GCATGCTGCCGAGAG	CCGCTGCTGCCGCTG	GCGCGCGGAGGTGCT
CGCGCGGAGGTGCTG	CGGGCCCCCGCCGGT	GCATGCCATGCGCGG
GCGCGGAGGTGCTGT	GGGCCCCCGCCGGTT	CATGCCATGCGCGGA
CGCGGAGGTGCTGTT	GGCCCCCGCCGGTTG	ATGCCATGCGCGGAG
GCGGAGGTGCTGTTC	GCCCCCGCCGGTTGC	TGCCATGCGCGGAGC
CGGAGGTGCTGTTCC	CCCCCGCCGGTTGCG	GCCATGCGCGGAGCT
GGAGGTGCTGTTCCG	CCCCGCCGGTTGCGC	CCATGCGCGGAGCTC
GAGGTGCTGTTCCGC	CCCGCCGGTTGCGCC	CATGCGCGGAGCTCG
AGGTGCTGTTCCGCT	CCGCCGGTTGCGCCG	ATGCGCGGAGCTCGT
GGTGCTGTTCCGCTG	CGCCGGTTGCGCCGC	TGCGCGGAGCTCGTC
GTGCTGTTCCGCTGC	GCCGGTTGCGCCGCC	GCGCGGAGCTCGTCC
TGCTGTTCCGCTGCC	CCGGTTGCGCCGCCC	CGCGGAGCTCGTCCG
GCTGTTCCGCTGCCC	CGGTTGCGCCGCCCG	GCGGAGCTCGTCCGG
CTGTTCCGCTGCCCG	GGTTGCGCCGCCCGC	CGGAGCTCGTCCGGG
TGTTCCGCTGCCCGC	GTTGCGCCGCCCGCC	GGAGCTCGTCCGGGA
GTTCCGCTGCCCGCC	TTGCGCCGCCCGCCG	GAGCTCGTCCGGGAG
TTCCGCTGCCCGCCC	TGCGCCGCCCGCCGC	AGCTCGTCCGGGAGC
TCCGCTGCCCGCCCT	GCGCCGCCCGCCGCG	GCTCGTCCGGGAGCC
CCGCTGCCCGCCCTG	CGCCGCCCGCCGCGG	CTCGTCCGGGAGCCG
CGCTGCCCGCCCTGC	GCCGCCCGCCGCGGT	TCGTCCGGGAGCCGG
GCTGCCCGCCCTGCA	CCGCCCGCCGCGGTG	CGTCCGGGAGCCGGG
CTGCCCGCCCTGCAC	CGCCCGCCGCGGTGG	GTCCGGGAGCCGGGC
TGCCCGCCCTGCACA	GCCCGCCGCGGTGGC	TCCGGGAGCCGGGCT
GCCCGCCCTGCACAC	CCCGCCGCGGTGGCC	CCGGGAGCCGGGCTG
CCCGCCCTGCACACC	CCGCCGCGGTGGCCG	CGGGAGCCGGGCTGC
CCGCCCTGCACACCC	CGCCGCGGTGGCCGC	GGGAGCCGGGCTGCG
CGCCCTGCACACCCG	GCCGCGGTGGCCGCA	GGAGCCGGGCTGCGG
GCCCTGCACACCCGA	CCGCGGTGGCCGCAG	GAGCCGGGCTGCGGC
CCCTGCACACCCGAG	CGCGGTGGCCGCAGT	AGCCGGGCTGCGGCT
CCTGCACACCCGAGC	GCGGTGGCCGCAGTG	GCCGGGCTGCGGCTG
CTGCACACCCGAGCG	CGGTGGCCGCAGTGG	CCGGGCTGCGGCTGC
TGCACACCCGAGCGC	GGTGGCCGCAGTGGC	CGGGCTGCGGCTGCT
GCACACCCGAGCGCC	GTGGCCGCAGTGGCC	GGGCTGCGGCTGCTG
CACACCCGAGCGCCT	TGGCCGCAGTGGCCG	GGCTGCGGCTGCTGC
ACACCCGAGCGCCTG	GGCCGCAGTGGCCGG	GCTGCGGCTGCTGCT
CACCCGAGCGCCTGG	GCCGCAGTGGCCGGA	CTGCGGCTGCTGCTC
ACCCGAGCGCCTGGC	CCGCAGTGGCCGGAG	TGCGGCTGCTGCTCG
CCCGAGCGCCTGGCC	CGCAGTGGCCGGAGG	GCGGCTGCTGCTCGG
CCGAGCGCCTGGCCG	GCAGTGGCCGGAGGC	CGGCTGCTGCTCGGT
CGAGCGCCTGGCCGC	CAGTGGCCGGAGGCG	GGCTGCTGCTCGGTG
GAGCGCCTGGCCGCC	AGTGGCCGGAGGCGC	GCTGCTGCTCGGTGT
AGCGCCTGGCCGCCT	GTGGCCGGAGGCGCC	CTGCTGCTCGGTGTG
GCGCCTGGCCGCCTG	TGGCCGGAGGCGCCC	TGCTGCTCGGTGTGC
CGCCTGGCCGCCTGC	GGCCGGAGGCGCCCG	GCTGCTCGGTGTGCG
GCCTGGCCGCCTGCG	GCCGGAGGCGCCCGC	CTGCTCGGTGTGCGC
CCTGGCCGCCTGCGG	CCGGAGGCGCCCGCA	TGCTCGGTGTGCGCC
CTGGCCGCCTGCGGG	CGGAGGCGCCCGCAT	GCTCGGTGTGCGCCC
TGGCCGCCTGCGGGC	GGAGGCGCCCGCATG	CTCGGTGTGCGCCCG
GGCCGCCTGCGGGCC	GAGGCGCCCGCATGC	TCGGTGTGCGCCCGG
GCCGCCTGCGGGCCC	AGGCGCCCGCATGCC	CGGTGTGCGCCCGGC
CCGCCTGCGGGCCCC	GGCGCCCGCATGCCA	GGTGTGCGCCCGGCT
CGCCTGCGGGCCCCC	GCGCCCGCATGCCAT	GTGTGCGCCCGGCTG
GCCTGCGGGCCCCCG	CGCCCGCATGCCATG	TGTGCGCCCGGCTGG
CCTGCGGGCCCCCGC	GCCCGCATGCCATGC	GTGCGCCCGGCTGGA
CTGCGGGCCCCCGCC	CCCGCATGCCATGCG	TGCGCCCGGCTGGAG
TGCGGGCCCCCGCCG	CCGCATGCCATGCGC	GCGCCCGGCTGGAGG
GCGGGCCCCCGCCGG	CGCATGCCATGCGCG	CGCCCGGCTGGAGGG
GCCCGGCTGGAGGGC	GCGCTGCTATCCCCA	AGGGCACTTGTGAGA
CCCGGCTGGAGGGCG	CGCTGCTATCCCCAC	GGGCACTTGTGAGAA
CCGGCTGGAGGGCGA	GCTGCTATCCCCACC	GGCACTTGTGAGAAG
CGGCTGGAGGGCGAG	CTGCTATCCCCACCC	GCACTTGTGAGAAGC
GGCTGGAGGGCGAGG	TGCTATCCCCACCCG	CACTTGTGAGAAGCG
GCTGGAGGGCGAGGC	GCTATCCCCACCCGG	ACTTGTGAGAAGCGC
CTGGAGGGCGAGGCG	CTATCCCCACCCGGG	CTTGTGAGAAGCGCC
TGGAGGGCGAGGCGT	TATCCCCACCCGGGC	TTGTGAGAAGCGCCG
GGAGGGCGAGGCGTG	ATCCCCACCCGGGCT	TGTGAGAAGCGCCGG
GAGGGCGAGGCGTGC	TCCCCACCCGGGCTC	GTGAGAAGCGCCGGG
AGGGCGAGGCGTGCG	CCCCACCCGGGCTCC	TGAGAAGCGCCGGGA
GGGCGAGGCGTGCGG	CCCACCCGGGCTCCG	GAGAAGCGCCGGGAC
GGCGAGGCGTGCGGC	CCACCCGGGCTCCGA	AGAAGCGCCGGGACG
GCGAGGCGTGCGGCG	CACCCGGGCTCCGAG	GAAGCGCCGGGACGC
CGAGGCGTGCGGCGT	ACCCGGGCTCCGAGC	AAGCGCCGGGACGCC
GAGGCGTGCGGCGTC	CCCGGGCTCCGAGCT	AGCGCCGGGACGCCG
AGGCGTGCGGCGTCT	CCGGGCTCCGAGCTG	GCGCCGGGACGCCGA
GGCGTGCGGCGTCTA	CGGGCTCCGAGCTGC	CGCCGGGACGCCGAG
GCGTGCGGCGTCTAC	GGGCTCCGAGCTGCC	GCCGGGACGCCGAGT
CGTGCGGCGTCTACA	GGCTCCGAGCTGCCC	CCGGGACGCCGAGTA
GTGCGGCGTCTACAC	GCTCCGAGCTGCCCC	CGGGACGCCGAGTAT
TGCGGCGTCTACACC	CTCCGAGCTGCCCCT	GGGACGCCGAGTATG
GCGGCGTCTACACCC	TCCGAGCTGCCCCTG	GGACGCCGAGTATGG
CGGCGTCTACACCCC	CCGAGCTGCCCCTGC	GACGCCGAGTATGGC
GGCGTCTACACCCCG	CGAGCTGCCCCTGCA	ACGCCGAGTATGGCG
GCGTCTACACCCCGC	GAGCTGCCCCTGCAG	CGCCGAGTATGGCGC
CGTCTACACCCCGCG	AGCTGCCCCTGCAGG	GCCGAGTATGGCGCC
GTCTACACCCCGCGC	GCTGCCCCTGCAGGC	CCGAGTATGGCGCCA
TCTACACCCCGCGCT	CTGCCCCTGCAGGCG	CGAGTATGGCGCCAG
CTACACCCCGCGCTG	TGCCCCTGCAGGCGC	GAGTATGGCGCCAGC
TACACCCCGCGCTGC	GCCCCTGCAGGCGCT	AGTATGGCGCCAGCC
ACACCCCGCGCTGCG	CCCCTGCAGGCGCTG	GTATGGCGCCAGCCC
CACCCCGCGCTGCGG	CCCTGCAGGCGCTGG	TATGGCGCCAGCCCG
ACCCCGCGCTGCGGC	CCTGCAGGCGCTGGT	ATGGCGCCAGCCCGG
CCCCGCGCTGCGGCC	CTGCAGGCGCTGGTC	TGGCGCCAGCCCGGA
CCCGCGCTGCGGCCA	TGCAGGCGCTGGTCA	GGCGCCAGCCCGGAG
CCGCGCTGCGGCCAG	GCAGGCGCTGGTCAT	GCGCCAGCCCGGAGC
CGCGCTGCGGCCAGG	CAGGCGCTGGTCATG	CGCCAGCCCGGAGCA
GCGCTGCGGCCAGGG	AGGCGCTGGTCATGG	GCCAGCCCGGAGCAG
CGCTGCGGCCAGGGG	GGCGCTGGTCATGGG	CCAGCCCGGAGCAGG
GCTGCGGCCAGGGGC	GCGCTGGTCATGGGC	CAGCCCGGAGCAGGT
CTGCGGCCAGGGGCT	CGCTGGTCATGGGCG	AGCCCGGAGCAGGTT
TGCGGCCAGGGGCTG	GCTGGTCATGGGCGA	GCCCGGAGCAGGTTG
GCGGCCAGGGGCTGC	CTGGTCATGGGCGAG	CCCGGAGCAGGTTGC
CGGCCAGGGGCTGCG	TGGTCATGGGCGAGG	CCGGAGCAGGTTGCA
GGCCAGGGGCTGCGC	GGTCATGGGCGAGGG	CGGAGCAGGTTGCAG
GCCAGGGGCTGCGCT	GTCATGGGCGAGGGC	GGAGCAGGTTGCAGA
CCAGGGGCTGCGCTG	TCATGGGCGAGGGCA	GAGCAGGTTGCAGAC
CAGGGGCTGCGCTGC	CATGGGCGAGGGCAC	AGCAGGTTGCAGACA
AGGGGCTGCGCTGCT	ATGGGCGAGGGCACT	GCAGGTTGCAGACAA
GGGGCTGCGCTGCTA	TGGGCGAGGGCACTT	CAGGTTGCAGACAAT
GGGCTGCGCTGCTAT	GGGCGAGGGCACTTG	AGGTTGCAGACAATG
GGCTGCGCTGCTATC	GGCGAGGGCACTTGT	GGTTGCAGACAATGG
GCTGCGCTGCTATCC	GCGAGGGCACTTGTG	GTTGCAGACAATGGC
CTGCGCTGCTATCCC	CGAGGGCACTTGTGA	TTGCAGACAATGGCG
TGCGCTGCTATCCCC	GAGGGCACTTGTGAG	TGCAGACAATGGCGA
GCAGACAATGGCGAT	CACCATGAACATGTT	GTATGAAGGAGCTGG
CAGACAATGGCGATG	ACCATGAACATGTTG	TATGAAGGAGCTGGC
AGACAATGGCGATGA	CCATGAACATGTTGG	ATGAAGGAGCTGGCC
GACAATGGCGATGAC	CATGAACATGTTGGG	TGAAGGAGCTGGCCG
ACAATGGCGATGACC	ATGAACATGTTGGGC	GAAGGAGCTGGCCGT
CAATGGCGATGACCA	TGAACATGTTGGGCG	AAGGAGCTGGCCGTG
AATGGCGATGACCAC	GAACATGTTGGGCGG	AGGAGCTGGCCGTGT
ATGGCGATGACCACT	AACATGTTGGGCGGG	GGAGCTGGCCGTGTT
TGGCGATGACCACTC	ACATGTTGGGCGGGG	GAGCTGGCCGTGTTC
GGCGATGACCACTCA	CATGTTGGGCGGGGG	AGCTGGCCGTGTTCC
GCGATGACCACTCAG	ATGTTGGGCGGGGGA	GCTGGCCGTGTTCCG
CGATGACCACTCAGA	TGTTGGGCGGGGGAG	CTGGCCGTGTTCCGG
GATGACCACTCAGAA	GTTGGGCGGGGGAGG	TGGCCGTGTTCCGGG
ATGACCACTCAGAAG	TTGGGCGGGGGAGGC	GGCCGTGTTCCGGGA
TGACCACTCAGAAGG	TGGGCGGGGGAGGCA	GCCGTGTTCCGGGAG
GACCACTCAGAAGGA	GGGCGGGGGAGGCAG	CCGTGTTCCGGGAGA
ACCACTCAGAAGGAG	GGCGGGGGAGGCAGT	CGTGTTCCGGGAGAA
CCACTCAGAAGGAGG	GCGGGGGAGGCAGTG	GTGTTCCGGGAGAAG
CACTCAGAAGGAGGC	CGGGGGAGGCAGTGC	TGTTCCGGGAGAAGG
ACTCAGAAGGAGGCC	GGGGGAGGCAGTGCT	GTTCCGGGAGAAGGT
CTCAGAAGGAGGCCT	GGGGAGGCAGTGCTG	TTCCGGGAGAAGGTC
TCAGAAGGAGGCCTG	GGGAGGCAGTGCTGG	TCCGGGAGAAGGTCA
CAGAAGGAGGCCTGG	GGAGGCAGTGCTGGC	CCGGGAGAAGGTCAC
AGAAGGAGGCCTGGT	GAGGCAGTGCTGGCC	CGGGAGAAGGTCACT
GAAGGAGGCCTGGTG	AGGCAGTGCTGGCCG	GGGAGAAGGTCACTG
AAGGAGGCCTGGTGG	GGCAGTGCTGGCCGG	GGAGAAGGTCACTGA
AGGAGGCCTGGTGGA	GCAGTGCTGGCCGGA	GAGAAGGTCACTGAG
GGAGGCCTGGTGGAG	CAGTGCTGGCCGGAA	AGAAGGTCACTGAGC
GAGGCCTGGTGGAGA	AGTGCTGGCCGGAAG	GAAGGTCACTGAGCA
AGGCCTGGTGGAGAA	GTGCTGGCCGGAAGC	AAGGTCACTGAGCAG
GGCCTGGTGGAGAAC	TGCTGGCCGGAAGCC	AGGTCACTGAGCAGC
GCCTGGTGGAGAACC	GCTGGCCGGAAGCCC	GGTCACTGAGCAGCA
CCTGGTGGAGAACCA	CTGGCCGGAAGCCCC	GTCACTGAGCAGCAC
CTGGTGGAGAACCAC	TGGCCGGAAGCCCCT	TCACTGAGCAGCACC
TGGTGGAGAACCACG	GGCCGGAAGCCCCTC	CACTGAGCAGCACCG
GGTGGAGAACCACGT	GCCGGAAGCCCCTCA	ACTGAGCAGCACCGG
GTGGAGAACCACGTG	CCGGAAGCCCCTCAA	CTGAGCAGCACCGGC
TGGAGAACCACGTGG	CGGAAGCCCCTCAAG	TGAGCAGCACCGGCA
GGAGAACCACGTGGA	GGAAGCCCCTCAAGT	GAGCAGCACCGGCAG
GAGAACCACGTGGAC	GAAGCCCCTCAAGTC	AGCAGCACCGGCAGA
AGAACCACGTGGACA	AAGCCCCTCAAGTCG	GCAGCACCGGCAGAT
GAACCACGTGGACAG	AGCCCCTCAAGTCGG	CAGCACCGGCAGATG
AACCACGTGGACAGC	GCCCCTCAAGTCGGG	AGCACCGGCAGATGG
ACCACGTGGACAGCA	CCCCTCAAGTCGGGT	GCACCGGCAGATGGG
CCACGTGGACAGCAC	CCCTCAAGTCGGGTA	CACCGGCAGATGGGC
CACGTGGACAGCACC	CCTCAAGTCGGGTAT	ACCGGCAGATGGGCA
ACGTGGACAGCACCA	CTCAAGTCGGGTATG	CCGGCAGATGGGCAA
CGTGGACAGCACCAT	TCAAGTCGGGTATGA	CGGCAGATGGGCAAG
GTGGACAGCACCATG	CAAGTCGGGTATGAA	GGCAGATGGGCAAGG
TGGACAGCACCATGA	AAGTCGGGTATGAAG	GCAGATGGGCAAGGG
GGACAGCACCATGAA	AGTCGGGTATGAAGG	CAGATGGGCAAGGGT
GACAGCACCATGAAC	GTCGGGTATGAAGGA	AGATGGGCAAGGGTG
ACAGCACCATGAACA	TCGGGTATGAAGGAG	GATGGGCAAGGGTGG
CAGCACCATGAACAT	CGGGTATGAAGGAGC	ATGGGCAAGGGTGGC
AGCACCATGAACATG	GGGTATGAAGGAGCT	TGGGCAAGGGTGGCA
GCACCATGAACATGT	GGTATGAAGGAGCTG	GGGCAAGGGTGGCAA
GGCAAGGGTGGCAAG	CCCTGCCAGGACTCC	CCATGCGCCTTCCGG
GCAAGGGTGGCAAGC	CCTGCCAGGACTCCC	CATGCGCCTTCCGGA
CAAGGGTGGCAAGCA	CTGCCAGGACTCCCT	ATGCGCCTTCCGGAT
AAGGGTGGCAAGCAT	TGCCAGGACTCCCTG	TGCGCCTTCCGGATG
AGGGTGGCAAGCATC	GCCAGGACTCCCTGC	GCGCCTTCCGGATGA
GGGTGGCAAGCATCA	CCAGGACTCCCTGCC	CGCCTTCCGGATGAG
GGTGGCAAGCATCAC	CAGGACTCCCTGCCA	GCCTTCCGGATGAGC
GTGGCAAGCATCACC	AGGACTCCCTGCCAA	CCTTCCGGATGAGCG
TGGCAAGCATCACCT	GGACTCCCTGCCAAC	CTTCCGGATGAGCGG
GGCAAGCATCACCTT	GACTCCCTGCCAACA	TTCCGGATGAGCGGG
GCAAGCATCACCTTG	ACTCCCTGCCAACAG	TCCGGATGAGCGGGG
CAAGCATCACCTTGG	CTCCCTGCCAACAGG	CCGGATGAGCGGGGC
AAGCATCACCTTGGC	TCCCTGCCAACAGGA	CGGATGAGCGGGGCC
AGCATCACCTTGGCC	CCCTGCCAACAGGAA	GGATGAGCGGGGCCC
GCATCACCTTGGCCT	CCTGCCAACAGGAAC	GATGAGCGGGGCCCT
CATCACCTTGGCCTG	CTGCCAACAGGAACT	ATGAGCGGGGCCCTC
ATCACCTTGGCCTGG	TGCCAACAGGAACTG	TGAGCGGGGCCCTCT
TCACCTTGGCCTGGA	GCCAACAGGAACTGG	GAGCGGGGCCCTCTG
CACCTTGGCCTGGAG	CCAACAGGAACTGGA	AGCGGGGCCCTCTGG
ACCTTGGCCTGGAGG	CAACAGGAACTGGAC	GCGGGGCCCTCTGGA
CCTTGGCCTGGAGGA	AACAGGAACTGGACC	CGGGGCCCTCTGGAG
CTTGGCCTGGAGGAG	ACAGGAACTGGACCA	GGGGCCCTCTGGAGC
TTGGCCTGGAGGAGC	CAGGAACTGGACCAG	GGGCCCTCTGGAGCA
TGGCCTGGAGGAGCC	AGGAACTGGACCAGG	GGCCCTCTGGAGCAC
GGCCTGGAGGAGCCC	GGAACTGGACCAGGT	GCCCTCTGGAGCACC
GCCTGGAGGAGCCCA	GAACTGGACCAGGTC	CCCTCTGGAGCACCT
CCTGGAGGAGCCCAA	AACTGGACCAGGTCC	CCTCTGGAGCACCTC
CTGGAGGAGCCCAAG	ACTGGACCAGGTCCT	CTCTGGAGCACCTCT
TGGAGGAGCCCAAGA	CTGGACCAGGTCCTG	TCTGGAGCACCTCTA
GGAGGAGCCCAAGAA	TGGACCAGGTCCTGG	CTGGAGCACCTCTAC
GAGGAGCCCAAGAAG	GGACCAGGTCCTGGA	TGGAGCACCTCTACT
AGGAGCCCAAGAAGC	GACCAGGTCCTGGAG	GGAGCACCTCTACTC
GGAGCCCAAGAAGCT	ACCAGGTCCTGGAGC	GAGCACCTCTACTCC
GAGCCCAAGAAGCTG	CCAGGTCCTGGAGCG	AGCACCTCTACTCCC
AGCCCAAGAAGCTGC	CAGGTCCTGGAGCGG	GCACCTCTACTCCCT
GCCCAAGAAGCTGCG	AGGTCCTGGAGCGGA	CACCTCTACTCCCTG
CCCAAGAAGCTGCGA	GGTCCTGGAGCGGAT	ACCTCTACTCCCTGC
CCAAGAAGCTGCGAC	GTCCTGGAGCGGATC	CCTCTACTCCCTGCA
CAAGAAGCTGCGACC	TCCTGGAGCGGATCT	CTCTACTCCCTGCAC
AAGAAGCTGCGACCA	CCTGGAGCGGATCTC	TCTACTCCCTGCACA
AGAAGCTGCGACCAC	CTGGAGCGGATCTCC	CTACTCCCTGCACAT
GAAGCTGCGACCACC	TGGAGCGGATCTCCA	TACTCCCTGCACATC
AAGCTGCGACCACCC	GGAGCGGATCTCCAC	ACTCCCTGCACATCC
AGCTGCGACCACCCC	GAGCGGATCTCCACC	CTCCCTGCACATCCC
GCTGCGACCACCCCC	AGCGGATCTCCACCA	TCCCTGCACATCCCC
CTGCGACCACCCCCT	GCGGATCTCCACCAT	CCCTGCACATCCCCA
TGCGACCACCCCCTG	CGGATCTCCACCATG	CCTGCACATCCCCAA
GCGACCACCCCCTGC	GGATCTCCACCATGC	CTGCACATCCCCAAC
CGACCACCCCCTGCC	GATCTCCACCATGCG	TGCACATCCCCAACT
GACCACCCCCTGCCA	ATCTCCACCATGCGC	GCACATCCCCAACTG
ACCACCCCCTGCCAG	TCTCCACCATGCGCC	CACATCCCCAACTGT
CCACCCCCTGCCAGG	CTCCACCATGCGCCT	ACATCCCCAACTGTG
CACCCCCTGCCAGGA	TCCACCATGCGCCTT	CATCCCCAACTGTGA
ACCCCCTGCCAGGAC	CCACCATGCGCCTTC	ATCCCCAACTGTGAC
CCCCCTGCCAGGACT	CACCATGCGCCTTCC	TCCCCAACTGTGACA
CCCCTGCCAGGACTC	ACCATGCGCCTTCCG	CCCCAACTGTGACAA
CCCAACTGTGACAAG	CGGGCAGCGTGGGGA	GAGCCCCCACCATCC
CCAACTGTGACAAGC	GGGCAGCGTGGGGAG	AGCCCCCACCATCCG
CAACTGTGACAAGCA	GGCAGCGTGGGGAGT	GCCCCCACCATCCGG
AACTGTGACAAGCAT	GCAGCGTGGGGAGTG	CCCCCACCATCCGGG
ACTGTGACAAGCATG	CAGCGTGGGGAGTGC	CCCCACCATCCGGGG
CTGTGACAAGCATGG	AGCGTGGGGAGTGCT	CCCACCATCCGGGGG
TGTGACAAGCATGGC	GCGTGGGGAGTGCTG	CCACCATCCGGGGGG
GTGACAAGCATGGCC	CGTGGGGAGTGCTGG	CACCATCCGGGGGGA
TGACAAGCATGGCCT	GTGGGGAGTGCTGGT	ACCATCCGGGGGGAC
GACAAGCATGGCCTG	TGGGGAGTGCTGGTG	CCATCCGGGGGGACC
ACAAGCATGGCCTGT	GGGGAGTGCTGGTGT	CATCCGGGGGGACCC
CAAGCATGGCCTGTA	GGGAGTGCTGGTGTG	ATCCGGGGGGACCCC
AAGCATGGCCTGTAC	GGAGTGCTGGTGTGT	TCCGGGGGGACCCCG
AGCATGGCCTGTACA	GAGTGCTGGTGTGTG	CCGGGGGGACCCCGA
GCATGGCCTGTACAA	AGTGCTGGTGTGTGA	CGGGGGGACCCCGAG
CATGGCCTGTACAAC	GTGCTGGTGTGTGAA	GGGGGGACCCCGAGT
ATGGCCTGTACAACC	TGCTGGTGTGTGAAC	GGGGGACCCCGAGTG
TGGCCTGTACAACCT	GCTGGTGTGTGAACC	GGGGACCCCGAGTGT
GGCCTGTACAACCTC	CTGGTGTGTGAACCC	GGGACCCCGAGTGTC
GCCTGTACAACCTCA	TGGTGTGTGAACCCC	GGACCCCGAGTGTCA
CCTGTACAACCTCAA	GGTGTGTGAACCCCA	GACCCCGAGTGTCAT
CTGTACAACCTCAAA	GTGTGTGAACCCCAA	ACCCCGAGTGTCATC
TGTACAACCTCAAAC	TGTGTGAACCCCAAC	CCCCGAGTGTCATCT
GTACAACCTCAAACA	GTGTGAACCCCAACA	CCCGAGTGTCATCTC
TACAACCTCAAACAG	TGTGAACCCCAACAC	CCGAGTGTCATCTCT
ACAACCTCAAACAGT	GTGAACCCCAACACC	CGAGTGTCATCTCTT
CAACCTCAAACAGTG	TGAACCCCAACACCG	GAGTGTCATCTCTTC
AACCTCAAACAGTGC	GAACCCCAACACCGG	AGTGTCATCTCTTCT
ACCTCAAACAGTGCA	AACCCCAACACCGGG	GTGTCATCTCTTCTA
CCTCAAACAGTGCAA	ACCCCAACACCGGGA	TGTCATCTCTTCTAC
CTCAAACAGTGCAAG	CCCCAACACCGGGAA	GTCATCTCTTCTACA
TCAAACAGTGCAAGA	CCCAACACCGGGAAG	TCATCTCTTCTACAA
CAAACAGTGCAAGAT	CCAACACCGGGAAGC	CATCTCTTCTACAAT
AAACAGTGCAAGATG	CAACACCGGGAAGCT	ATCTCTTCTACAATG
AACAGTGCAAGATGT	AACACCGGGAAGCTG	TCTCTTCTACAATGA
ACAGTGCAAGATGTC	ACACCGGGAAGCTGA	CTCTTCTACAATGAG
CAGTGCAAGATGTCT	CACCGGGAAGCTGAT	TCTTCTACAATGAGC
AGTGCAAGATGTCTC	ACCGGGAAGCTGATC	CTTCTACAATGAGCA
GTGCAAGATGTCTCT	CCGGGAAGCTGATCC	TTCTACAATGAGCAG
TGCAAGATGTCTCTG	CGGGAAGCTGATCCA	TCTACAATGAGCAGC
GCAAGATGTCTCTGA	GGGAAGCTGATCCAG	CTACAATGAGCAGCA
CAAGATGTCTCTGAA	GGAAGCTGATCCAGG	TACAATGAGCAGCAG
AAGATGTCTCTGAAC	GAAGCTGATCCAGGG	ACAATGAGCAGCAGG
AGATGTCTCTGAACG	AAGCTGATCCAGGGA	CAATGAGCAGCAGGA
GATGTCTCTGAACGG	AGCTGATCCAGGGAG	AATGAGCAGCAGGAG
ATGTCTCTGAACGGG	GCTGATCCAGGGAGC	ATGAGCAGCAGGAGG
TGTCTCTGAACGGGC	CTGATCCAGGGAGCC	TGAGCAGCAGGAGGC
GTCTCTGAACGGGCA	TGATCCAGGGAGCCC	GAGCAGCAGGAGGCT
TCTCTGAACGGGCAG	GATCCAGGGAGCCCC	AGCAGCAGGAGGCTT
CTCTGAACGGGCAGC	ATCCAGGGAGCCCCC	GCAGCAGGAGGCTTG
TCTGAACGGGCAGCG	TCCAGGGAGCCCCCA	CAGCAGGAGGCTTGC
CTGAACGGGCAGCGT	CCAGGGAGCCCCCAC	AGCAGGAGGCTTGCG
TGAACGGGCAGCGTG	CAGGGAGCCCCCACC	GCAGGAGGCTTGCGG
GAACGGGCAGCGTGG	AGGGAGCCCCCACCA	CAGGAGGCTTGCGGG
AACGGGCAGCGTGGG	GGGAGCCCCCACCAT	AGGAGGCTTGCGGGG
ACGGGCAGCGTGGGG	GGAGCCCCCACCATC	GGAGGCTTGCGGGGT
GAGGCTTGCGGGGTG	GGCGCCCCTGCCCCC	GTGGTGGGTGCTGGA
AGGCTTGCGGGGTGC	GCGCCCCTGCCCCCC	TGGTGGGTGCTGGAG
GGCTTGCGGGGTGCA	CGCCCCTGCCCCCCG	GGTGGGTGCTGGAGG
GCTTGCGGGGTGCAC	GCCCCTGCCCCCCGC	GTGGGTGCTGGAGGA
CTTGCGGGGTGCACA	CCCCTGCCCCCCGCC	TGGGTGCTGGAGGAT
TTGCGGGGTGCACAC	CCCTGCCCCCCGCCC	GGGTGCTGGAGGATT
TGCGGGGTGCACACC	CCTGCCCCCCGCCCC	GGTGCTGGAGGATTT
GCGGGGTGCACACCC	CTGCCCCCCGCCCCT	GTGCTGGAGGATTTT
CGGGGTGCACACCCA	TGCCCCCCGCCCCTC	TGCTGGAGGATTTTC
GGGGTGCACACCCAG	GCCCCCCGCCCCTCT	GCTGGAGGATTTTCC
GGGTGCACACCCAGC	CCCCCCGCCCCTCTC	CTGGAGGATTTTCCA
GGTGCACACCCAGCG	CCCCCGCCCCTCTCC	TGGAGGATTTTCCAG
GTGCACACCCAGCGG	CCCCGCCCCTCTCCA	GGAGGATTTTCCAGT
TGCACACCCAGCGGA	CCCGCCCCTCTCCAA	GAGGATTTTCCAGTT
GCACACCCAGCGGAT	CCGCCCCTCTCCAAA	AGGATTTTCCAGTTC
CACACCCAGCGGATG	CGCCCCTCTCCAAAC	GGATTTTCCAGTTCT
ACACCCAGCGGATGC	GCCCCTCTCCAAACA	GATTTTCCAGTTCTG
CACCCAGCGGATGCA	CCCCTCTCCAAACAC	ATTTTCCAGTTCTGA
ACCCAGCGGATGCAG	CCCTCTCCAAACACC	TTTTCCAGTTCTGAC
CCCAGCGGATGCAGT	CCTCTCCAAACACCG	TTTCCAGTTCTGACA
CCAGCGGATGCAGTA	CTCTCCAAACACCGG	TTCCAGTTCTGACAC
CAGCGGATGCAGTAG	TCTCCAAACACCGGC	TCCAGTTCTGACACA
AGCGGATGCAGTAGA	CTCCAAACACCGGCA	CCAGTTCTGACACAC
GCGGATGCAGTAGAC	TCCAAACACCGGCAG	CAGTTCTGACACACG
CGGATGCAGTAGACC	CCAAACACCGGCAGA	AGTTCTGACACACGT
GGATGCAGTAGACCG	CAAACACCGGCAGAA	GTTCTGACACACGTA
GATGCAGTAGACCGC	AAACACCGGCAGAAA	TTCTGACACACGTAT
ATGCAGTAGACCGCA	AACACCGGCAGAAAA	TCTGACACACGTATT
TGCAGTAGACCGCAG	ACACCGGCAGAAAAC	CTGACACACGTATTT
GCAGTAGACCGCAGC	CACCGGCAGAAAACG	TGACACACGTATTTA
CAGTAGACCGCAGCC	ACCGGCAGAAAACGG	GACACACGTATTTAT
AGTAGACCGCAGCCA	CCGGCAGAAAACGGA	ACACACGTATTTATA
GTAGACCGCAGCCAG	CGGCAGAAAACGGAG	CACACGTATTTATAT
TAGACCGCAGCCAGC	GGCAGAAAACGGAGA	ACACGTATTTATATT
AGACCGCAGCCAGCC	GCAGAAAACGGAGAG	CACGTATTTATATTT
GACCGCAGCCAGCCG	CAGAAAACGGAGAGT	ACGTATTTATATTTG
ACCGCAGCCAGCCGG	AGAAAACGGAGAGTG	CGTATTTATATTTGG
CCGCAGCCAGCCGGT	GAAAACGGAGAGTGC	GTATTTATATTTGGA
CGCAGCCAGCCGGTG	AAAACGGAGAGTGCT	TATTTATATTTGGAA
GCAGCCAGCCGGTGC	AAACGGAGAGTGCTT	ATTTATATTTGGAAA
CAGCCAGCCGGTGCC	AACGGAGAGTGCTTG	TTTATATTTGGAAAG
AGCCAGCCGGTGCCT	ACGGAGAGTGCTTGG	TTATATTTGGAAAGA
GCCAGCCGGTGCCTG	CGGAGAGTGCTTGGG	TATATTTGGAAAGAG
CCAGCCGGTGCCTGG	GGAGAGTGCTTGGGT	ATATTTGGAAAGAGA
CAGCCGGTGCCTGGC	GAGAGTGCTTGGGTG	TATTTGGAAAGAGAC
AGCCGGTGCCTGGCG	AGAGTGCTTGGGTGG	ATTTGGAAAGAGACC
GCCGGTGCCTGGCGC	GAGTGCTTGGGTGGT	TTTGGAAAGAGACCA
CCGGTGCCTGGCGCC	AGTGCTTGGGTGGTG	TTGGAAAGAGACCAG
CGGTGCCTGGCGCCC	GTGCTTGGGTGGTGG	TGGAAAGAGACCAGC
GGTGCCTGGCGCCCC	TGCTTGGGTGGTGGG	GGAAAGAGACCAGCA
GTGCCTGGCGCCCCT	GCTTGGGTGGTGGGT	GAAAGAGACCAGCAC
TGCCTGGCGCCCCTG	CTTGGGTGGTGGGTG	AAAGAGACCAGCACC
GCCTGGCGCCCCTGC	TTGGGTGGTGGGTGC	AAGAGACCAGCACCG
CCTGGCGCCCCTGCC	TGGGTGGTGGGTGCT	AGAGACCAGCACCGA
CTGGCGCCCCTGCCC	GGGTGGTGGGTGCTG	GAGACCAGCACCGAG
TGGCGCCCCTGCCCC	GGTGGTGGGTGCTGG	AGACCAGCACCGAGC
GACCAGCACCGAGCT	CACCTGCTCCTTCTT	GGGTACAGGTTTGGG
ACCAGCACCGAGCTC	ACCTGCTCCTTCTTG	GGTACAGGTTTGGGG
CCAGCACCGAGCTCG	CCTGCTCCTTCTTGC	GTACAGGTTTGGGGA
CAGCACCGAGCTCGG	CTGCTCCTTCTTGCT	TACAGGTTTGGGGAG
AGCACCGAGCTCGGC	TGCTCCTTCTTGCTT	ACAGGTTTGGGGAGG
GCACCGAGCTCGGCA	GCTCCTTCTTGCTTT	CAGGTTTGGGGAGGG
CACCGAGCTCGGCAC	CTCCTTCTTGCTTTC	AGGTTTGGGGAGGGG
ACCGAGCTCGGCACC	TCCTTCTTGCTTTCC	GGTTTGGGGAGGGGG
CCGAGCTCGGCACCT	CCTTCTTGCTTTCCC	CTTTGGGGAGGGGGA
CGAGCTCGGCACCTC	CTTCTTGCTTTCCCC	TTTGGGGAGGGGGAA
GAGCTCGGCACCTCC	TTCTTGCTTTCCCCG	TTGGGGAGGGGGAAG
AGCTCGGCACCTCCC	TCTTGCTTTCCCCGC	TGGGGAGGGGGAAGA
GCTCGGCACCTCCCC	CTTGCTTTCCCCGGG	GGGGAGGGGGAAGAG
CTCGGCACCTCCCCG	TTGCTTTCCCCGGGG	GGGAGGGGGAAGAGA
TCGGCACCTCCCCGG	TGCTTTCCCCGGGGG	GGAGGGGGAAGAGAA
CGGCACCTCCCCGGC	GCTTTCCCCGGGGGA	GAGGGGGAAGAGAAA
GGCACCTCCCCGGCC	CTTTCCCCGGGGGAG	AGGGGGAAGAGAAAT
GCACCTCCCCGGCCT	TTTCCCCGGGGGAGG	GGGGGAAGAGAAATT
CACCTCCCCGGCCTC	TTCCCCGGGGGAGGA	GGGGAAGAGAAATTT
ACCTCCCCGGCCTCT	TCCCCGGGGGAGGAA	GGGAAGAGAAATTTT
CCTCCCCGGCCTCTC	CCCCGGGGGAGGAAG	GGAAGAGAAATTTTT
CTCCCCGGCCTCTCT	CCCGGGGGAGGAAGG	GAAGAGAAATTTTTA
TCCCCGGCCTCTCTC	CCGGGGGAGGAAGGG	AAGAGAAATTTTTAT
CCCCGGCCTCTCTCT	CGGGGGAGGAAGGGG	AGAGAAATTTTTATT
CCCGGCCTCTCTCTT	GGGGGAGGAAGGGGG	GAGAAATTTTTATTT
CCGGCCTCTCTCTTC	GGGGAGGAAGGGGGT	AGAAATTTTTATTTT
CGGCCTCTCTCTTCC	GGGAGGAAGGGGGTT	GAAATTTTTATTTTT
GGCCTCTCTCTTCCC	GGAGGAAGGGGGTTG	AAATTTTTATTTTTG
GCCTCTCTCTTCCCA	GAGGAAGGGGGTTGT	AATTTTTATTTTTGA
CCTCTCTCTTCCCAG	AGGAAGGGGGTTGTG	ATTTTTATTTTTGAA
CTCTCTCTTCCCAGC	GGAAGGGGGTTGTGG	TTTTTATTTTTGAAC
TCTCTCTTCCCAGCT	GAAGGGGGTTGTGGT	TTTTATTTTTGAACC
CTCTCTTCCCAGCTG	AAGGGGGTTGTGGTC	TTTATTTTTGAACCC
TCTCTTCCCAGCTGC	AGGGGGTTGTGGTCG	TTATTTTTGAACCCC
CTCTTCCCAGCTGCA	GGGGGTTGTGGTCGG	TATTTTTGAACCCCT
TCTTCCCAGCTGCAG	GGGGTTGTGGTCGGG	ATTTTTGAACCCCTG
CTTCCCAGCTGCAGA	GGGTTGTGGTCGGGG	TTTTTGAACCCCTGT
TTCCCAGCTGCAGAT	GGTTGTGGTCGGGGA	TTTTGAACCCCTGTG
TCCCAGCTGCAGATG	GTTGTGGTCGGGGAG	TTTGAACCCCTGTGT
CCCAGCTGCAGATGC	TTGTGGTCGGGGAGC	TTGAACCCCTGTGTC
CCAGCTGCAGATGCC	TGTGGTCGGGGAGCT	TGAACCCCTGTGTCC
CAGCTGCAGATGCCA	GTGGTCGGGGAGCTG	GAACCCCTGTGTCCC
AGCTGCAGATGCCAC	TGGTCGGGGAGCTGG	AACCCCTGTGTCCCT
GCTGCAGATGCCACA	GGTCGGGGAGCTGGG	ACCCCTGTGTCCCTT
CTGCAGATGCCACAC	GTCGGGGAGCTGGGG	CCCCTGTGTCCCTTT
TGCAGATGCCACACC	TCGGGGAGCTGGGGT	CCCTGTGTCCCTTTT
GCAGATGCCACACCT	CGGGGAGCTGGGGTA	CCTGTGTCCCTTTTG
CAGATGCCACACCTG	GGGGAGCTGGGGTAC	CTGTGTCCCTTTTGC
AGATGCCACACCTGC	GGGAGCTGGGGTACA	TGTGTCCCTTTTGCA
GATGCCACACCTGCT	GGAGCTGGGGTACAG	GTGTCCCTTTTGCAT
ATGCCACACCTGCTC	GAGCTGGGGTACAGG	TGTCCCTTTTGCATA
TGCCACACCTGCTCC	AGCTGGGGTACAGGT	GTCCCTTTTGCATAA
GCCACACCTGCTCCT	GCTGGGGTACAGGTT	TCCCTTTTGCATAAG
CCACACCTGCTCCTT	CTGGGGTACAGGTTT	CCCTTTTGCATAAGA
CACACCTGCTCCTTC	TGGGGTACAGGTTTG	CCTTTTGCATAAGAT
ACACCTGCTCCTTCT	GGGGTACAGGTTTGG	CTTTTGCATAAGATT
TTTTGCATAAGATTA
TTTGCATAAGATTAA
TTGCATAAGATTAAA
TGCATAAGATTAAAG
GCATAAGATTAAAGG
CATAAGATTAAAGGA
ATAAGATTAAAGGAA
TAAGATTAAAGGAAG
AAGATTAAAGGAAGG
AGATTAAAGGAAGGA
GATTAAAGGAAGGAA
ATTAAAGGAAGGAAA
TTAAAGGAAGGAAAA
TAAAGGAAGGAAAAG
AAAGGAAGGAAAAGT

EXAMPLE 7

Antisense Oligonucleotides of IGFBP3

[0057] Antisense oligonucleotides to IGFBP3 may be selected from molecules capable of interacting with one or more of the following sense oligonucleotides:

CTCAGCGCCCAGCCG	CCACAGCTTCGCGCC	ATCCCTGCGCGCCCA
TCAGCGCCCAGCCGC	CACAGCTTCGCGCCG	TCCCTGCGCGCCCAG
CAGCGCCCAGCCGCT	ACAGCTTCGCGCCGT	CCCTGCGCGCCCAGC
AGCGCCCAGCCGCTT	CAGCTTCGCGCCGTG	CCTGCGCGCCCAGCC
GCGCCCAGCCGCTTC	AGCTTCGCGCCGTGT	CTGCGCGCCCAGCCT
CGCCCAGCCGCTTCC	GCTTCGCGCCGTGTA	TGCGCGCCCAGCCTG
GCCCAGCCGCTTCCT	CTTCGCGCCGTGTAC	GCGCGCCCAGCCTGC
CCCAGCCGCTTCCTG	TTCGCGCCGTGTACT	CGCGCCCAGCCTGCC
CCAGCCGCTTCCTGC	TCGCGCCGTGTACTG	GCGCCCAGCCTGCCA
CAGCCGCTTCCTGCC	CGCGCCGTGTACTGT	CGCCCAGCCTGCCAA
AGCCGCTTCCTGCCT	GCGCCGTGTACTGTC	GCCCAGCCTGCCAAG
GCCGCTTCCTGCCTG	CGCCGTGTACTGTCG	CCCAGCCTGCCAAGC
CCGCTTCCTGCCTGG	GCCGTGTACTGTCGC	CCAGCCTGCCAAGCA
CGCTTCCTGCCTGGA	CCGTGTACTGTCGCC	CAGCCTGCCAAGCAG
GCTTCCTGCCTGGAT	CGTGTACTGTCGCCC	AGCCTGCCAAGCAGC
CTTCCTGCCTGGATT	GTGTACTGTCGCCCC	GCCTGCCAAGCAGCG
TTCCTGCCTGGATTC	TGTACTGTCGCCCCA	CCTGCCAAGCAGCGT
TCCTGCCTGGATTCC	GTACTGTCGCCCCAT	CTGCCAAGCAGCGTG
CCTGCCTGGATTCCA	TACTGTCGCCCCATC	TGCCAAGCAGCGTGC
CTGCCTGGATTCCAC	ACTGTCGCCCCATCC	GCCAAGCAGCGTGCC
TGCCTGGATTCCACA	CTGTCGCCCCATCCC	CCAAGCAGCGTGCCC
GCCTGGATTCCACAG	TGTCGCCCCATCCCT	CAAGCAGCGTGCCCC
CCTGGATTCCACAGC	GTCGCCCCATCCCTG	AAGCAGCGTGCCCCG
CTGGATTCCACAGCT	TCGCCCCATCCCTGC	AGCAGCGTGCCCCGG
TGGATTCCACAGCTT	CGCCCCATCCCTGCG	GCAGCGTGCCCCGGT
GGATTCCACAGCTTC	GCCCCATCCCTGCGC	CAGCGTGCCCCGGTT
GATTCCACAGCTTCG	CCCCATCCCTGCGCG	AGCGTGCCCCGGTTG
ATTCCACAGCTTCGC	CCCATCCCTGCGCGC	GCGTGCCCCGGTTGC
TTCCACAGCTTCGCG	CCATCCCTGCGCGCC	CGTGCCCCGGTTGCA
TCCACAGCTTCGCGC	CATCCCTGCGCGCCC	GTGCCCCGGTTGCAG
TGCCCCGGTTGCAGG	TGACTCTGCTGGTGC	GGGGGCTTGGGTCCC
GCCCCGGTTGCAGGC	GACTCTGCTGGTGCT	GGGGCTTGGGTCCCG
CCCCGGTTGCAGGCG	ACTCTGCTGGTGCTG	GGGCTTGGGTCCCGT
CCCGGTTGCAGGCGT	CTCTGCTGGTGCTGC	GGCTTGGGTCCCGTG
CCGGTTGCAGGCGTC	TCTGCTGGTGCTGCT	GCTTGGGTCCCGTGG
CGGTTGCAGGCGTCA	CTGCTGGTGCTGCTC	CTTGGGTCCCGTGGT
GGTTGCAGGCGTCAT	TGCTGGTGCTGCTCC	TTGGGTCCCGTGGTG
GTTGCAGGCGTCATG	GCTGGTGCTGCTCCG	TGGGTCCCGTGGTGC
TTGCAGGCGTCATGC	CTGGTGCTGCTCCGC	GGGTCCCGTGGTGCG
TGCAGGCGTCATGCA	TGGTGCTGCTCCGCG	GGTCCCGTGGTGCGC
GCAGGCGTCATGCAG	GGTGCTGCTCCGCGG	GTCCCGTGGTGCGCT
CAGGCGTCATGCAGC	GTGCTGCTCCGCGGG	TCCCGTGGTGCGCTG
AGGCGTCATGCAGCG	TGCTGCTCCGCGGGC	CCCGTGGTGCGCTGC
GGCGTCATGCAGCGG	GCTGCTCCGCGGGCC	CCGTGGTGCGCTGCG
GCGTCATGCAGCGGG	CTGCTCCGCGGGCCG	CGTGGTGCGCTGCGA
CGTCATGCAGCGGGC	TGCTCCGCGGGCCGC	GTGGTGCGCTGCGAG
GTCATGCAGCGGGCG	GCTCCGCGGGCCGCC	TGGTGCGCTGCGAGC
TCATGCAGCGGGCGC	CTCCGCGGGCCGCCG	GGTGCGCTGCGAGCC
CATGCAGCGGGCGCG	TCCGCGGGCCGCCGG	GTGCGCTGCGAGCCG
ATGCAGCGGGCGCGA	CCGCGGGCCGCCGGT	TGCGCTGCGAGCCGT
TGCAGCGGGCGCGAC	CGCGGGCCGCCGGTG	GCGCTGCGAGCCGTG
GCAGCGGGCGCGACC	GCGGGCCGCCGGTGG	CGCTGCGAGCCGTGC
CAGCGGGCGCGACCC	CGGGCCGCCGGTGGC	GCTGCGAGCCGTGCG
AGCGGGCGCGACCCA	GGGCCGCCGGTGGCG	CTGCGAGCCGTGCGA
GCGGGCGCGACCCAC	GGCCGCCGGTGGCGC	TGCGAGCCGTGCGAC
CGGGCGCGACCCACG	GCCGCCGGTGGCGCG	GCGAGCCGTGCGACG
GGGCGCGACCCACGC	CCGCCGGTGGCGCGG	CGAGCCGTGCGACGC
GGCGCGACCCACGCT	CGCCGGTGGCGCGGG	GAGCCGTGCGACGCG
GCGCGACCCACGCTC	GCCGGTGGCGCGGGC	AGCCGTGCGACGCGC
CGCGACCCACGCTCT	CCGGTGGCGCGGGCT	GCCGTGCGACGCGCG
GCGACCCACGCTCTG	CGGTGGCGCGGGCTG	CCGTGCGACGCGCGT
CGACCCACGCTCTGG	GGTGGCGCGGGCTGG	CGTGCGACGCGCGTG
GACCCACGCTCTGGG	GTGGCGCGGGCTGGC	GTGCGACGCGCGTGC
ACCCACGCTCTGGGC	TGGCGCGGGCTGGCG	TGCGACGCGCGTGCA
CCCACGCTCTGGGCC	GGCGCGGGCTGGCGC	GCGACGCGCGTGCAC
CCACGCTCTGGGCCG	GCGCGGGCTGGCGCG	CGACGCGCGTGCACT
CACGCTCTGGGCCGC	CGCGGGCTGGCGCGA	GACGCGCGTGCACTG
ACGCTCTGGGCCGCT	GCGGGCTGGCGCGAG	ACGCGCGTGCACTGG
CGCTCTGGGCCGCTG	CGGGCTGGCGCGAGC	CGCGCGTGCACTGGC
GCTCTGGGCCGCTGC	GGGCTGGCGCGAGCT	GCGCGTGCACTGGCC
CTCTGGGCCGCTGCG	GGCTGGCGCGAGCTC	CGCGTGCACTGGCCC
TCTGGGCCGCTGCGC	GCTGGCGCGAGCTCG	GCGTGCACTGGCCCA
CTGGGCCGCTGCGCT	CTGGCGCGAGCTCGG	CGTGCACTGGCCCAG
TGGGCCGCTGCGCTG	TGGCGCGAGCTCGGG	GTGCACTGGCCCAGT
GGGCCGCTGCGCTGA	GGCGCGAGCTCGGGG	TGCACTGGCCCAGTG
GGCCGCTGCGCTGAC	GCGCGAGCTCGGGGG	GCACTGGCCCAGTGC
GCCGCTGCGCTGACT	CGCGAGCTCGGGGGG	CACTGGCCCAGTGCG
CCGCTGCGCTGACTC	GCGAGCTCGGGGGGC	ACTGGCCCAGTGCGC
CGCTGCGCTGACTCT	CGAGCTCGGGGGGCT	CTGGCCCAGTGCGCG
GCTGCGCTGACTCTG	GAGCTCGGGGGGCTT	TGGCCCAGTGCGCGC
CTGCGCTGACTCTGC	AGCTCGGGGGGCTTG	GGCCCAGTGCGCGCC
TGCGCTGACTCTGCT	GCTCGGGGGGCTTGG	GCCCAGTGCGCGCCT
GCGCTGACTCTGCTG	CTCGGGGGGCTTGGG	CCCAGTGCGCGCCTC
CGCTGACTCTGCTGG	TCGGGGGGCTTGGGT	CCAGTGCGCGCCTCC
GCTGACTCTGCTGGT	CGGGGGGCTTGGGTC	CAGTGCGCGCCTCCG
CTGACTCTGCTGGTG	GGGGGGCTTGGGTCC	AGTGCGCGCCTCCGC
GTGCGCGCCTCCGCC	GCTGCCTGACGTGCG	TGTGGCTCCGGCCTT
TGCGCGCCTCCGCCC	CTGCCTGACGTGCGC	GTGGCTCCGGCCTTC
GCGCGCCTCCGCCCG	TGCCTGACGTGCGCA	TGGCTCCGGCCTTCG
CGCGCCTCCGCCCGC	GCCTGACGTGCGCAC	GGCTCCGGCCTTCGC
GCGCCTCCGCCCGCC	CCTGACGTGCGCACT	GCTCCGGCCTTCGCT
CGCCTCCGCCCGCCG	CTGACGTGCGCACTG	CTCCGGCCTTCGCTG
GCCTCCGCCCGCCGT	TGACGTGCGCACTGA	TCCGGCCTTCGCTGC
CCTCCGCCCGCCGTG	GACGTGCGCACTGAG	CCGGCCTTCGCTGCC
CTCCGCCCGCCGTGT	ACGTGCGCACTGAGC	CGGCCTTCGCTGCCA
TCCGCCCGCCGTGTG	CGTGCGCACTGAGCG	GGCCTTCGCTGCCAG
CCGCCCGCCGTGTGC	GTGCGCACTGAGCGA	GCCTTCGCTGCCAGC
CGCCCGCCGTGTGCG	TGCGCACTGAGCGAG	CCTTCGCTGCCAGCC
GCCCGCCGTGTGCGC	GCGCACTGAGCGAGG	CTTCGCTGCCAGCCG
CCCGCCGTGTGCGCG	CGCACTGAGCGAGGG	TTCGCTGCCAGCCGT
CCGCCGTGTGCGCGG	GCACTGAGCGAGGGC	TCGCTGCCAGCCGTC
CGCCGTGTGCGCGGA	CACTGAGCGAGGGCC	CGCTGCCAGCCGTCG
GCCGTGTGCGCGGAG	ACTGAGCGAGGGCCA	GCTGCCAGCCGTCGC
CCGTGTGCGCGGAGC	CTGAGCGAGGGCCAG	CTGCCAGCCGTCGCC
CGTGTGCGCGGAGCT	TGAGCGAGGGCCAGC	TGCCAGCCGTCGCCC
GTGTGCGCGGAGCTG	GAGCGAGGGCCAGCC	GCCAGCCGTCGCCCG
TGTGCGCGGAGCTGG	AGCGAGGGCCAGCCG	CCAGCCGTCGCCCGA
GTGCGCGGAGCTGGT	GCGAGGGCCAGCCGT	CAGCCGTCGCCCGAC
TGCGCGGAGCTGGTG	CGAGGGCCAGCCGTG	AGCCGTCGCCCGACG
GCGCGGAGCTGGTGC	GAGGGCCAGCCGTGC	GCCGTCGCCCGACGA
CGCGGAGCTGGTGCG	AGGGCCAGCCGTGCG	CCGTCGCCCGACGAG
GCGGAGCTGGTGCGC	GGGCCAGCCGTGCGG	CGTCGCCCGACGAGG
CGGAGCTGGTGCGCG	GGCCAGCCGTGCGGC	GTCGCCCGACGAGGC
GGAGCTGGTGCGCGA	GCCAGCCGTGCGGCA	TCGCCCGACGAGGCG
GAGCTGGTGCGCGAG	CCAGCCGTGCGGCAT	CGCCCGACGAGGCGC
AGCTGGTGCGCGAGC	CAGCCGTGCGGCATC	GCCCGACGAGGCGCG
GCTGGTGCGCGAGCC	AGCCGTGCGGCATCT	CCCGACGAGGCGCGA
CTGGTGCGCGAGCCG	GCCGTGCGGCATCTA	CCGACGAGGCGCGAC
TGGTGCGCGAGCCGG	CCGTGCGGCATCTAC	CGACGAGGCGCGACC
GGTGCGCGAGCCGGG	CGTGCGGCATCTACA	GACGAGGCGCGACCG
GTGCGCGAGCCGGGC	GTGCGGCATCTACAC	ACGAGGCGCGACCGC
TGCGCGAGCCGGGCT	TGCGGCATCTACACC	CGAGGCGCGACCGCT
GCGCGAGCCGGGCTG	GCGGCATCTACACCG	GAGGCGCGACCGCTG
CGCGAGCCGGGCTGC	CGGCATCTACACCGA	AGGCGCGACCGCTGC
GCGAGCCGGGCTGCG	GGCATCTACACCGAG	GGCGCGACCGCTGCA
CGAGCCGGGCTGCGG	GCATCTACACCGAGC	GCGCGACCGCTGCAG
GAGCCGGGCTGCGGC	CATCTACACCGAGCG	CGCGACCGCTGCAGG
AGCCGGGCTGCGGCT	ATCTACACCGAGCGC	GCGACCGCTGCAGGC
GCCGGGCTGCGGCTG	TCTACACCGAGCGCT	CGACCGCTGCAGGCG
CCGGGCTGCGGCTGC	CTACACCGAGCGCTG	GACCGCTGCAGGCGC
CGGGCTGCGGCTGCT	TACACCGAGCGCTGT	ACCGCTGCAGGCGCT
GGGCTGCGGCTGCTG	ACACCGAGCGCTGTG	CCGCTGCAGGCGCTG
GGCTGCGGCTGCTGC	CACCGAGCGCTGTGG	CGCTGCAGGCGCTGC
GCTGCGGCTGCTGCC	ACCGAGCGCTGTGGC	GCTGCAGGCGCTGCT
CTGCGGCTGCTGCCT	CCGAGCGCTGTGGCT	CTGCAGGCGCTGCTG
TGCGGCTGCTGCCTG	CGAGCGCTGTGGCTC	TGCAGGCGCTGCTGG
GCGGCTGCTGCCTGA	GAGCGCTGTGGCTCC	GCAGGCGCTGCTGGA
CGGCTGCTGCCTGAC	AGCGCTGTGGCTCCG	CAGGCGCTGCTGGAC
GGCTGCTGCCTGACG	GCGCTGTGGCTCCGG	AGGCGCTGCTGGACG
GCTGCTGCCTGACGT	CGCTGTGGCTCCGGC	GGCGCTGCTGGACGG
CTGCTGCCTGACGTG	GCTGTGGCTCCGGCC	GCGCTGCTGGACGGC
TGCTGCCTGACGTGC	CTGTGGCTCCGGCCT	CGCTGCTGGACGGCC
GCTGCTGGACGGCCG	CCTACCTGCTGCCAG	CGCAGCGCCGGCAGT
CTGCTGGACGGCCGC	CTACCTGCTGCCAGC	GCAGCGCCGGCAGTG
TGCTGGACGGCCGCG	TACCTGCTGCCAGCG	CAGCGCCGGCAGTGT
GCTGGACGGCCGCGG	ACCTGCTGCCAGCGC	AGCGCCGGCAGTGTG
CTGGACGGCCGCGGG	CCTGCTGCCAGCGCC	GCGCCGGCAGTGTGG
TGGACGGCCGCGGGC	CTGCTGCCAGCGCCG	CGCCGGCAGTGTGGA
GGACGGCCGCGGGCT	TGCTGCCAGCGCCGC	GCCGGCAGTGTGGAG
GACGGCCGCGGGCTC	GCTGCCAGCGCCGCC	CCGGCAGTGTGGAGA
ACGGCCGCGGGCTCT	CTGCCAGCGCCGCCA	CGGCAGTGTGGAGAG
CGGCCGCGGGCTCTG	TGCCAGCGCCGCCAG	GGCAGTGTGGAGAGC
GGCCGCGGGCTCTGC	GCCAGCGCCGCCAGC	GCAGTGTGGAGAGCC
GCCGCGGGCTCTGCG	CCAGCGCCGCCAGCT	CAGTGTGGAGAGCCC
CCGCGGGCTCTGCGT	CAGCGCCGCCAGCTC	AGTGTGGAGAGCCCG
CGCGGGCTCTGCGTC	AGCGCCGCCAGCTCC	GTGTGGAGAGCCCGT
GCGGGCTCTGCGTCA	GCGCCGCCAGCTCCA	TGTGGAGAGCCCGTC
CGGGCTCTGCGTCAA	CGCCGCCAGCTCCAG	GTGGAGAGCCCGTCC
GGGCTCTGCGTCAAC	GCCGCCAGCTCCAGG	TGGAGAGCCCGTCCG
GGCTCTGCGTCAACG	CCGCCAGCTCCAGGA	GGAGAGCCCGTCCGT
GCTCTGCGTCAACGC	CGCCAGCTCCAGGAA	GAGAGCCCGTCCGTC
CTCTGCGTCAACGCT	GCCAGCTCCAGGAAA	AGAGCCCGTCCGTCT
TCTGCGTCAACGCTA	CCAGCTCCAGGAAAT	GAGCCCGTCCGTCTC
CTGCGTCAACGCTAG	CAGCTCCAGGAAATG	AGCCCGTCCGTCTCC
TGCGTCAACGCTAGT	AGCTCCAGGAAATGC	GCCCGTCCGTCTCCA
GCGTCAACGCTAGTG	GCTCCAGGAAATGCT	CCCGTCCGTCTCCAG
CGTCAACGCTAGTGC	CTCCAGGAAATGCTA	CCGTCCGTCTCCAGC
GTCAACGCTAGTGCC	TCCAGGAAATGCTAG	CGTCCGTCTCCAGCA
TCAACGCTAGTGCCG	CCAGGAAATGCTAGT	GTCCGTCTCCAGCAC
CAACGCTAGTGCCGT	CAGGAAATGCTAGTG	TCCGTCTCCAGCACG
AACGCTAGTGCCGTC	AGGAAATGCTAGTGA	CCGTCTCCAGCACGC
ACGCTAGTGCCGTCA	GGAAATGCTAGTGAG	CGTCTCCAGCACGCA
CGCTAGTGCCGTCAG	GAAATGCTAGTGAGT	GTCTCCAGCACGCAC
GCTAGTGCCGTCAGC	AAATGCTAGTGAGTC	TCTCCAGCACGCACC
CTAGTGCCGTCAGCC	AATGCTAGTGAGTCG	CTCCAGCACGCACCG
TAGTGCCGTCAGCCG	ATGCTAGTGAGTCGG	TCCAGCACGCACCGG
AGTGCCGTCAGCCGC	TGCTAGTGAGTCGGA	CCAGCACGCACCGGG
GTGCCGTCAGCCGCC	GCTAGTGAGTCGGAG	CAGCACGCACCGGGT
TGCCGTCAGCCGCCT	CTAGTGAGTCGGAGG	AGCACGCACCGGGTG
GCCGTCAGCCGCCTG	TAGTGAGTCGGAGGA	GCACGCACCGGGTGT
CCGTCAGCCGCCTGC	AGTGAGTCGGAGGAA	CACGCACCGGGTGTC
CGTCAGCCGCCTGCG	GTGAGTCGGAGGAAG	ACGCACCGGGTGTCT
GTCAGCCGCCTGCGC	TGAGTCGGAGGAAGA	CGCACCGGGTGTCTG
TCAGCCGCCTGCGCG	GAGTCGGAGGAAGAC	GCACCGGGTGTCTGA
CAGCCGCCTGCGCGC	AGTCGGAGGAAGACC	CACCGGGTGTCTGAT
AGCCGCCTGCGCGCC	GTCGGAGGAAGACCG	ACCGGGTGTCTGATC
GCCGCCTGCGCGCCT	TCGGAGGAAGACCGC	CCGGGTGTCTGATCC
CCGCCTGCGCGCCTA	CGGAGGAAGACCGCA	CGGGTGTCTGATCCC
CGCCTGCGCGCCTAC	GGAGGAAGACCGCAG	GGGTGTCTGATCCCA
GCCTGCGCGCCTACC	GAGGAAGACCGCAGC	GGTGTCTGATCCCAA
CCTGCGCGCCTACCT	AGGAAGACCGCAGCG	GTGTCTGATCCCAAG
CTGCGCGCCTACCTG	GGAAGACCGCAGCGC	TGTCTGATCCCAAGT
TGCGCGCCTACCTGC	GAAGACCGCAGCGCC	GTCTGATCCCAAGTT
GCGCGCCTACCTGCT	AAGACCGCAGCGCCG	TCTGATCCCAAGTTC
CGCGCCTACCTGCTG	AGACCGCAGCGCCGG	CTGATCCCAAGTTCC
GCGCCTACCTGCTGC	GACCGCAGCGCCGGC	TGATCCCAAGTTCCA
CGCCTACCTGCTGCC	ACCGCAGCGCCGGCA	GATCCCAAGTTCCAC
GCCTACCTGCTGCCA	CCGCAGCGCCGGCAG	ATCCCAAGTTCCACC
TCCCAAGTTCCACCC	AAGACAGCCAGCGCT	TTCTCCTCCGAGTCC
CCCAAGTTCCACCCC	AGACAGCCAGCGCTA	TCTCCTCCGAGTCCA
CCAAGTTCCACCCCC	GACAGCCAGCGCTAC	CTCCTCCGAGTCCAA
CAAGTTCCACCCCCT	ACAGCCAGCGCTACA	TCCTCCGAGTCCAAG
AAGTTCCACCCCCTC	CAGCCAGCGCTACAA	CCTCCGAGTCCAAGC
AGTTCCACCCCCTCC	AGCCAGCGCTACAAA	CTCCGAGTCCAAGCG
GTTCCACCCCCTCCA	GCCAGCGCTACAAAG	TCCGAGTCCAAGCGG
TTCCACCCCCTCCAT	CCAGCGCTACAAAGT	CCGAGTCCAAGCGGG
TCCACCCCCTCCATT	CAGCGCTACAAAGTT	CGAGTCCAAGCGGGA
CCACCCCCTCCATTC	AGCGCTACAAAGTTG	GAGTCCAAGCGGGAG
CACCCCCTCCATTCA	GCGCTACAAAGTTGA	AGTCCAAGCGGGAGA
ACCCCCTCCATTCAA	CGCTACAAAGTTGAC	GTCCAAGCGGGAGAC
CCCCCTCCATTCAAA	GCTACAAAGTTGACT	TCCAAGCGGGAGACA
CCCCTCCATTCAAAG	CTACAAAGTTGACTA	CCAAGCGGGAGACAG
CCCTCCATTCAAAGA	TACAAAGTTGACTAC	CAAGCGGGAGACAGA
CCTCCATTCAAAGAT	ACAAAGTTGACTACG	AAGCGGGAGACAGAA
CTCCATTCAAAGATA	CAAAGTTGACTACGA	AGCGGGAGACAGAAT
TCCATTCAAAGATAA	AAAGTTGACTACGAG	GCGGGAGACAGAATA
CCATTCAAAGATAAT	AAGTTGACTACGAGT	CGGGAGACAGAATAT
CATTCAAAGATAATC	AGTTGACTACGAGTC	GGGAGACAGAATATG
ATTCAAAGATAATCA	GTTGACTACGAGTCT	GGAGACAGAATATGG
TTCAAAGATAATCAT	TTGACTACGAGTCTC	GAGACAGAATATGGT
TCAAAGATAATCATC	TGACTACGAGTCTCA	AGACAGAATATGGTC
CAAAGATAATCATCA	GACTACGAGTCTCAG	GACAGAATATGGTCC
AAAGATAATCATCAT	ACTACGAGTCTCAGA	ACAGAATATGGTCCC
AAGATAATCATCATC	CTACGAGTCTCAGAG	CAGAATATGGTCCCT
AGATAATCATCATCA	TACGAGTCTCAGAGC	AGAATATGGTCCCTG
GATAATCATCATCAA	ACGAGTCTCAGAGCA	GAATATGGTCCCTGC
ATAATCATCATCAAG	CGAGTCTCAGAGCAC	AATATGGTCCCTGCC
TAATCATCATCAAGA	GAGTCTCAGAGCACA	ATATGGTCCCTGCCG
AATCATCATCAAGAA	AGTCTCAGAGCACAG	TATGGTCCCTGCCGT
ATCATCATCAAGAAA	GTCTCAGAGCACAGA	ATGGTCCCTGCCGTA
TCATCATCAAGAAAG	TCTCAGAGCACAGAT	TGGTCCCTGCCGTAG
CATCATCAAGAAAGG	CTCAGAGCACAGATA	GGTCCCTGCCGTAGA
ATCATCAAGAAAGGG	TCAGAGCACAGATAC	GTCCCTGCCGTAGAG
TCATCAAGAAAGGGC	CAGAGCACAGATACC	TCCCTGCCGTAGAGA
CATCAAGAAAGGGCA	AGAGCACAGATACCC	CCCTGCCGTAGAGAA
ATCAAGAAAGGGCAT	GAGCACAGATACCCA	CCTGCCGTAGAGAAA
TCAAGAAAGGGCATG	AGCACAGATACCCAG	CTGCCGTAGAGAAAT
CAAGAAAGGGCATGC	GCACAGATACCCAGA	TGCCGTAGAGAAATG
AAGAAAGGGCATGCT	CACAGATACCCAGAA	GCCGTAGAGAAATGG
AGAAAGGGCATGCTA	ACAGATACCCAGAAC	CCGTAGAGAAATGGA
GAAAGGGCATGCTAA	CAGATACCCAGAACT	CGTAGAGAAATGGAA
AAAGGGCATGCTAAA	AGATACCCAGAACTT	GTAGAGAAATGGAAG
AAGGGCATGCTAAAG	GATACCCAGAACTTC	TAGAGAAATGGAAGA
AGGGCATGCTAAAGA	ATACCCAGAACTTCT	AGAGAAATGGAAGAC
GGGCATGCTAAAGAC	TACCCAGAACTTCTC	GAGAAATGGAAGACA
GGCATGCTAAAGACA	ACCCAGAACTTCTCC	AGAAATGGAAGACAC
GCATGCTAAAGACAG	CCCAGAACTTCTCCT	GAAATGGAAGACACA
CATGCTAAAGACAGC	CCAGAACTTCTCCTC	AAATGGAAGACACAC
ATGCTAAAGACAGCC	CAGAACTTCTCCTCC	AATGGAAGACACACT
TGCTAAAGACAGCCA	AGAACTTCTCCTCCG	ATGGAAGACACACTG
GCTAAAGACAGCCAG	GAACTTCTCCTCCGA	TGGAAGACACACTGA
CTAAAGACAGCCAGC	AACTTCTCCTCCGAG	GGAAGACACACTGAA
TAAAGACAGCCAGCG	ACTTCTCCTCCGAGT	GAAGACACACTGAAT
AAAGACAGCCAGCGC	CTTCTCCTCCGAGTC	AAGACACACTGAATC
AGACACACTGAATCA	TTCCCAACTGTGACA	GGCAGGAAGCGGGGC
GACACACTGAATCAC	TCCCAACTGTGACAA	GCAGGAAGCGGGGCT
ACACACTGAATCACC	CCCAACTGTGACAAG	CAGGAAGCGGGGCTT
CACACTGAATCACCT	CCAACTGTGACAAGA	AGGAAGCGGGGCTTC
ACACTGAATCACCTG	CAACTGTGACAAGAA	GGAAGCGGGGCTTCT
CACTGAATCACCTGA	AACTGTGACAAGAAG	GAAGCGGGGCTTCTG
ACTGAATCACCTGAA	ACTGTGACAAGAAGG	AAGCGGGGCTTCTGC
CTGAATCACCTGAAG	CTGTGACAAGAAGGG	AGCGGGGCTTCTGCT
TGAATCACCTGAAGT	TGTGACAAGAAGGGA	GCGGGGCTTCTGCTG
GAATCACCTGAAGTT	GTGACAAGAAGGGAT	CGGGGCTTCTGCTGG
AATCACCTGAAGTTC	TGACAAGAAGGGATT	GGGGCTTCTGCTGGT
ATCACCTGAAGTTCC	GACAAGAAGGGATTT	GGGCTTCTGCTGGTG
TCACCTGAAGTTCCT	ACAAGAAGGGATTTT	GGCTTCTGCTGGTGT
CACCTGAAGTTCCTC	CAAGAAGGGATTTTA	GCTTCTGCTGGTGTG
ACCTGAAGTTCCTCA	AAGAAGGGATTTTAT	CTTCTGCTGGTGTGT
CCTGAAGTTCCTCAA	AGAAGGGATTTTATA	TTCTGCTGGTGTGTG
CTGAAGTTCCTCAAT	GAAGGGATTTTATAA	TCTGCTGGTGTGTGG
TGAAGTTCCTCAATG	AAGGGATTTTATAAG	CTGCTGGTGTGTGGA
GAAGTTCCTCAATGT	AGGGATTTTATAAGA	TGCTGGTGTGTGGAT
AAGTTCCTCAATGTG	GGGATTTTATAAGAA	GCTGGTGTGTGGATA
AGTTCCTCAATGTGC	GGATTTTATAAGAAA	CTGGTGTGTGGATAA
GTTCCTCAATGTGCT	GATTTTATAAGAAAA	TGGTGTGTGGATAAG
TTCCTCAATGTGCTG	ATTTTATAAGAAAAA	GGTGTGTGGATAAGT
TCCTCAATGTGCTGA	TTTTATAAGAAAAAG	GTGTGTGGATAAGTA
CCTCAATGTGCTGAG	TTTATAAGAAAAAGC	TGTGTGGATAAGTAT
CTCAATGTGCTGAGT	TTATAAGAAAAAGCA	GTGTGGATAAGTATG
TCAATGTGCTGAGTC	TATAAGAAAAAGCAG	TGTGGATAAGTATGG
CAATGTGCTGAGTCC	ATAAGAAAAAGCAGT	GTGGATAAGTATGGG
AATGTGCTGAGTCCC	TAAGAAAAAGCAGTG	TGGATAAGTATGGGC
ATGTGCTGAGTCCCA	AAGAAAAAGCAGTGT	GGATAAGTATGGGCA
TGTGCTGAGTCCCAG	AGAAAAAGCAGTGTC	GATAAGTATGGGCAG
GTGCTGAGTCCCAGG	GAAAAAGCAGTGTCG	ATAAGTATGGGCAGC
TGCTGAGTCCCAGGG	AAAAAGCAGTGTCGC	TAAGTATGGGCAGCC
GCTGAGTCCCAGGGG	AAAAGCAGTGTCGCC	AAGTATGGGCAGCCT
CTGAGTCCCAGGGGT	AAAGCAGTGTCGCCC	AGTATGGGCAGCCTC
TGAGTCCCAGGGGTG	AAGCAGTGTCGCCCT	GTATGGGCAGCCTCT
GAGTCCCAGGGGTGT	AGCAGTGTCGCCCTT	TATGGGCAGCCTCTC
AGTCCCAGGGGTGTA	GCAGTGTCGCCCTTC	ATGGGCAGCCTCTCC
GTCCCAGGGGTGTAC	CAGTGTCGCCCTTCC	TGGGCAGCCTCTCCC
TCCCAGGGGTGTACA	AGTGTCGCCCTTCCA	GGGCAGCCTCTCCCA
CCCAGGGGTGTACAC	GTGTCGCCCTTCCAA	GGCAGCCTCTCCCAG
CCAGGGGTGTACACA	TGTCGCCCTTCCAAA	GCAGCCTCTCCCAGG
CAGGGGTGTACACAT	GTCGCCCTTCCAAAG	CAGCCTCTCCCAGGC
AGGGGTGTACACATT	TCGCCCTTCCAAAGG	AGCCTCTCCCAGGCT
GGGGTGTACACATTC	CGCCCTTCCAAAGGC	GCCTCTCCCAGGCTA
GGGTGTACACATTCC	GCCCTTCCAAAGGCA	CCTCTCCCAGGCTAC
GGTGTACACATTCCC	CCCTTCCAAAGGCAG	CTCTCCCAGGCTACA
GTGTACACATTCCCA	CCTTCCAAAGGCAGG	TCTCCCAGGCTACAC
TGTACACATTCCCAA	CTTCCAAAGGCAGGA	CTCCCAGGCTACACC
GTACACATTCCCAAC	TTCCAAAGGCAGGAA	TCCCAGGCTACACCA
TACACATTCCCAACT	TCCAAAGGCAGGAAG	CCCAGGCTACACCAC
ACACATTCCCAACTG	CCAAAGGCAGGAAGC	CCAGGCTACACCACC
CACATTCCCAACTGT	CAAAGGCAGGAAGCG	CAGGCTACACCACCA
ACATTCCCAACTGTG	AAAGGCAGGAAGCGG	AGGCTACACCACCAA
CATTCCCAACTGTGA	AAGGCAGGAAGCGGG	GGCTACACCACCAAG
ATTCCCAACTGTGAC	AGGCAGGAAGCGGGG	GCTACACCACCAAGG
CTACACCACCAAGGG	CGCCTGCCGCAAGTT	CCAAGGACATGACCA
TACACCACCAAGGGG	GCCTGCCGCAAGTTA	CAAGGACATGACCAG
ACACCACCAAGGGGA	CCTGCCGCAAGTTAA	AAGGACATGACCAGC
CACCACCAAGGGGAA	CTGCCGCAAGTTAAT	AGGACATGACCAGCA
ACCACCAAGGGGAAG	TGCCGCAAGTTAATG	GGACATGACCAGCAG
CCACCAAGGGGAAGG	GCCGCAAGTTAATGT	GACATGACCAGCAGC
CACCAAGGGGAAGGA	CCGCAAGTTAATGTG	ACATGACCAGCAGCT
ACCAAGGGGAAGGAG	CGCAAGTTAATGTGG	CATGACCAGCAGCTG
CCAAGGGGAAGGAGG	GCAAGTTAATGTGGA	ATGACCAGCAGCTGG
CAAGGGGAAGGAGGA	CAAGTTAATGTGGAG	TGACCAGCAGCTGGC
AAGGGGAAGGAGGAC	AAGTTAATGTGGAGC	GACCAGCAGCTGGCT
AGGGGAAGGAGGACG	AGTTAATGTGGAGCT	ACCAGCAGCTGGCTA
GGGGAAGGAGGACGT	GTTAATGTGGAGCTC	CCAGCAGCTGGCTAC
GGGAAGGAGGACGTG	TTAATGTGGAGCTCA	CAGCAGCTGGCTACA
GGAAGGAGGACGTGC	TAATGTGGAGCTCAA	AGCAGCTGGCTACAG
GAAGGAGGACGTGCA	AATGTGGAGCTCAAA	GCAGCTGGCTACAGC
AAGGAGGACGTGCAC	ATGTGGAGCTCAAAT	CAGCTGGCTACAGCC
AGGAGGACGTGCACT	TGTGGAGCTCAAATA	AGCTGGCTACAGCCT
GGAGGACGTGCACTG	GTGGAGCTCAAATAT	GCTGGCTACAGCCTC
GAGGACGTGCACTGC	TGGAGCTCAAATATG	CTGGCTACAGCCTCG
AGGACGTGCACTGCT	GGAGCTCAAATATGC	TGGCTACAGCCTCGA
GGACGTGCACTGCTA	GAGCTCAAATATGCC	GGCTACAGCCTCGAT
GACGTGCACTGCTAC	AGCTCAAATATGCCT	GCTACAGCCTCGATT
ACGTGCACTGCTACA	GCTCAAATATGCCTT	CTACAGCCTCGATTT
CGTGCACTGCTACAG	CTCAAATATGCCTTA	TACAGCCTCGATTTA
GTGCACTGCTACAGC	TCAAATATGCCTTAT	ACAGCCTCGATTTAT
TGCACTGCTACAGCA	CAAATATGCCTTATT	CAGCCTCGATTTATA
GCACTGCTACAGCAT	AAATATGCCTTATTT	AGCCTCGATTTATAT
CACTGCTACAGCATG	AATATGCCTTATTTT	GCCTCGATTTATATT
ACTGCTACAGCATGC	ATATGCCTTATTTTG	CCTCGATTTATATTT
CTGCTACAGCATGCA	TATGCCTTATTTTGC	CTCGATTTATATTTC
TGCTACAGCATGCAG	ATGCCTTATTTTGCA	TCGATTTATATTTCT
GCTACAGCATGCAGA	TGCCTTATTTTGCAC	CGATTTATATTTCTG
CTACAGCATGCAGAG	GCCTTATTTTGCACA	GATTTATATTTCTGT
TACAGCATGCAGAGC	CCTTATTTTGCACAA	ATTTATATTTCTGTT
ACAGCATGCAGAGCA	CTTATTTTGCACAAA	TTTATATTTCTGTTT
CAGCATGCAGAGCAA	TTATTTTGCACAAAA	TTATATTTCTGTTTG
AGCATGCAGAGCAAG	TATTTTGCACAAAAG	TATATTTCTGTTTGT
GCATGCAGAGCAAGT	ATTTTGCACAAAAGA	ATATTTCTGTTTGTG
CATGCAGAGCAAGTA	TTTTGCACAAAAGAC	TATTTCTGTTTGTGG
ATGCAGAGCAAGTAG	TTTGCACAAAAGACT	ATTTCTGTTTGTGGT
TGCAGAGCAAGTAGA	TTGCACAAAAGACTG	TTTCTGTTTGTGGTG
GCAGAGCAAGTAGAC	TGCACAAAAGACTGC	TTCTGTTTGTGGTGA
CAGAGCAAGTAGACG	GCACAAAAGACTGCC	TCTGTTTGTGGTGAA
AGAGCAAGTAGACGC	CACAAAAGACTGCCA	CTGTTTGTGGTGAAC
GAGCAAGTAGACGCC	ACAAAAGACTGCCAA	TGTTTGTGGTGAACT
AGCAAGTAGACGCCT	CAAAAGACTGCCAAG	GTTTGTGGTGAACTG
GCAAGTAGACGCCTG	AAAAGACTGCCAAGG	TTTGTGGTGAACTGA
CAAGTAGACGCCTGC	AAAGACTGCCAAGGA	TTGTGGTGAACTGAT
AAGTAGACGCCTGCC	AAGACTGCCAAGGAC	TGTGGTGAACTGATT
AGTAGACGCCTGCCG	AGACTGCCAAGGACA	GTGGTGAACTGATTT
GTAGACGCCTGCCGC	GACTGCCAAGGACAT	TGGTGAACTGATTTT
TAGACGCCTGCCGCA	ACTGCCAAGGACATG	GGTGAACTGATTTTT
AGACGCCTGCCGCAA	CTGCCAAGGACATGA	GTGAACTGATTTTTT
GACGCCTGCCGCAAG	TGCCAAGGACATGAC	TGAACTGATTTTTTT
ACGCCTGCCGCAAGT	GCCAAGGACATGACC	GAACTGATTTTTTTT
AACTGATTTTTTTTA	CTTTGAATGGTAAAC	TTGAATTTTCTTGTC
ACTGATTTTTTTTAA	TTTGAATGGTAAACT	TGAATTTTCTTGTCG
CTGATTTTTTTTAAA	TTGAATGGTAAACTT	GAATTTTCTTGTCGC
TGATTTTTTTTAAAC	TGAATGGTAAACTTG	AATTTTCTTGTCGCT
GATTTTTTTTAAACC	GAATGGTAAACTTGA	ATTTTCTTGTCGCTT
ATTTTTTTTAAACCA	AATGGTAAACTTGAG	TTTTCTTGTCGCTTC
TTTTTTTTAAACCAA	ATGGTAAACTTGAGC	TTTCTTGTCGCTTCC
TTTTTTTAAACCAAA	TGGTAAACTTGAGCA	TTCTTGTCGCTTCCT
TTTTTTAAACCAAAG	GGTAAACTTGAGCAT	TCTTGTCGCTTCCTA
TTTTTAAACCAAAGT	GTAAACTTGAGCATC	CTTGTCGCTTCCTAT
TTTTAAACCAAAGTT	TAAACTTGAGCATCT	TTGTCGCTTCCTATC
TTTAAACCAAAGTTT	AAACTTGAGCATCTT	TGTCGCTTCCTATCA
TTAAACCAAAGTTTA	AACTTGAGCATCTTT	GTCGCTTCCTATCAA
TAAACCAAAGTTTAG	ACTTGAGCATCTTTT	TCGCTTCCTATCAAA
AAACCAAAGTTTAGA	CTTGAGCATCTTTTC	CGCTTCCTATCAAAA
AACCAAAGTTTAGAA	TTGAGCATCTTTTCA	GCTTCCTATCAAAAT
ACCAAAGTTTAGAAA	TGAGCATCTTTTCAC	CTTCCTATCAAAATA
CCAAAGTTTAGAAAG	GAGCATCTTTTCACT	TTCCTATCAAAATAT
CAAAGTTTAGAAAGA	AGCATCTTTTCACTT	TCCTATCAAAATATT
AAAGTTTAGAAAGAG	GCATCTTTTCACTTT	CCTATCAAAATATTC
AAGTTTAGAAAGAGG	CATCTTTTCACTTTC	CTATCAAAATATTCA
AGTTTAGAAAGAGGT	ATCTTTTCACTTTCC	TATCAAAATATTCAG
GTTTAGAAAGAGGTT	TCTTTTCACTTTCCA	ATCAAAATATTCAGA
TTTAGAAAGAGGTTT	CTTTTCACTTTCCAG	TCAAAATATTCAGAG
TTAGAAAGAGGTTTT	TTTTCACTTTCCAGT	CAAAATATTCAGAGA
TAGAAAGAGGTTTTT	TTTCACTTTCCAGTA	AAAATATTCAGAGAC
AGAAAGAGGTTTTTG	TTCACTTTCCAGTAG	AAATATTCAGAGACT
GAAAGAGGTTTTTGA	TCACTTTCCAGTAGT	AATATTCAGAGACTC
AAAGAGGTTTTTGAA	CACTTTCCAGTAGTC	ATATTCAGAGACTCG
AAGAGGTTTTTGAAA	ACTTTCCAGTAGTCA	TATTCAGAGACTCGA
AGAGGTTTTTGAAAT	CTTTCCAGTAGTCAG	ATTCAGAGACTCGAG
GAGGTTTTTGAAATG	TTTCCAGTAGTCAGC	TTCAGAGACTCGAGC
AGGTTTTTGAAATGC	TTCCAGTAGTCAGCA	TCAGAGACTCGAGCA
GGTTTTTGAAATGCC	TCCAGTAGTCAGCAA	CAGAGACTCGAGCAC
GTTTTTGAAATGCCT	CCAGTAGTCAGCAAA	AGAGACTCGAGCACA
TTTTTGAAATGCCTA	CAGTAGTCAGCAAAG	GAGACTCGAGCACAG
TTTTGAAATGCCTAT	AGTAGTCAGCAAAGA	AGACTCGAGCACAGC
TTTGAAATGCCTATG	GTAGTCAGCAAAGAG	GACTCGAGCACAGCA
TTGAAATGCCTATGG	TAGTCAGCAAAGAGC	ACTCGAGCACAGCAC
TGAAATGCCTATGGT	AGTCAGCAAAGAGCA	CTCGAGCACAGCACC
GAAATGCCTATGGTT	GTCAGCAAAGAGCAG	TCGAGCACAGCACCC
AAATGCCTATGGTTT	TCAGCAAAGAGCAGT	CGAGCACAGCACCCA
AATGCCTATGGTTTC	CAGCAAAGAGCAGTT	GAGCACAGCACCCAG
ATGCCTATGGTTTCT	AGCAAAGAGCAGTTT	AGCACAGCACCCAGA
TGCCTATGGTTTCTT	GCAAAGAGCAGTTTG	GCACAGCACCCAGAC
GCCTATGGTTTCTTT	CAAAGAGCAGTTTGA	CACAGCACCCAGACT
CCTATGGTTTCTTTG	AAAGAGCAGTTTGAA	ACAGCACCCAGACTT
CTATGGTTTCTTTGA	AAGAGCAGTTTGAAT	CAGCACCCAGACTTC
TATGGTTTCTTTGAA	AGAGCAGTTTGAATT	AGCACCCAGACTTCA
ATGGTTTCTTTGAAT	GAGCAGTTTGAATTT	GCACCCAGACTTCAT
TGGTTTCTTTGAATG	AGCAGTTTGAATTTT	CACCCAGACTTCATG
GGTTTCTTTGAATGG	GCAGTTTGAATTTTC	ACCCAGACTTCATGC
GTTTCTTTGAATGGT	CAGTTTGAATTTTCT	CCCAGACTTCATGCG
TTTCTTTGAATGGTA	AGTTTGAATTTTCTT	CCAGACTTCATGCGC
TTCTTTGAATGGTAA	GTTTGAATTTTCTTG	CAGACTTCATGCGCC
TCTTTGAATGGTAAA	TTTGAATTTTCTTGT	AGACTTCATGCGCCC
GACTTCATGCGCCCG	ACTTTGTGACTTAGG	CCCCGTACAGTGCGC
ACTTCATGCGCCCGT	CTTTGTGACTTAGGC	CCCGTACAGTGCGCA
CTTCATGCGCCCGTG	TTTGTGACTTAGGCG	CCGTACAGTGCGCAC
TTCATGCGCCCGTGG	TTGTGACTTAGGCGG	CGTACAGTGCGCACA
TCATGCGCCCGTGGA	TGTGACTTAGGCGGC	GTACAGTGCGCACAG
CATGCGCCCGTGGAA	GTGACTTAGGCGGCT	TACAGTGCGCACAGG
ATGCGCCCGTGGAAT	TGACTTAGGCGGCTG	ACAGTGCGCACAGGC
TGCGCCCGTGGAATG	GACTTAGGCGGCTGT	CAGTGCGCACAGGCT
GCGCCCGTGGAATGC	ACTTAGGCGGCTGTG	AGTGCGCACAGGCTT
CGCCCGTGGAATGCT	CTTAGGCGGCTGTGT	GTGCGCACAGGCTTT
GCCCGTGGAATGCTC	TTAGGCGGCTGTGTT	TGCGCACAGGCTTTA
CCCGTGGAATGCTCA	TAGGCGGCTGTGTTG	GCGCACAGGCTTTAT
CCGTGGAATGCTCAC	AGGCGGCTGTGTTGC	CGCACAGGCTTTATC
CGTGGAATGCTCACC	GGCGGCTGTGTTGCC	GCACAGGCTTTATCG
GTGGAATGCTCACCA	GCGGCTGTGTTGCCT	CACAGGCTTTATCGA
TGGAATGCTCACCAC	CGGCTGTGTTGCCTA	ACAGGCTTTATCGAG
GGAATGCTCACCACA	GGCTGTGTTGCCTAT	CAGGCTTTATCGAGA
GAATGCTCACCACAT	GCTGTGTTGCCTATG	AGGCTTTATCGAGAA
AATGCTCACCACATG	CTGTGTTGCCTATGT	GGCTTTATCGAGAAT
ATGCTCACCACATGT	TGTGTTGCCTATGTA	GCTTTATCGAGAATA
TGCTCACCACATGTT	GTGTTGCCTATGTAG	CTTTATCGAGAATAG
GCTCACCACATGTTG	TGTTGCCTATGTAGA	TTTATCGAGAATAGG
CTCACCACATGTTGG	GTTGCCTATGTAGAG	TTATCGAGAATAGGA
TCACCACATGTTGGT	TTGCCTATGTAGAGA	TATCGAGAATAGGAA
CACCACATGTTGGTC	TGCCTATGTAGAGAA	ATCGAGAATAGGAAA
ACCACATGTTGGTCG	GCCTATGTAGAGAAC	TCGAGAATAGGAAAA
CCACATGTTGGTCGA	CCTATGTAGAGAACA	CGAGAATAGGAAAAC
CACATGTTGGTCGAA	CTATGTAGAGAACAC	GAGAATAGGAAAACC
ACATGTTGGTCGAAG	TATGTAGAGAACACG	AGAATAGGAAAACCT
CATGTTGGTCGAAGC	ATGTAGAGAACACGC	GAATAGGAAAACCTT
ATGTTGGTCGAAGCG	TGTAGAGAACACGCT	AATAGGAAAACCTTT
TGTTGGTCGAAGCGG	GTAGAGAACACGCTT	ATAGGAAAACCTTTA
GTTGGTCGAAGCGGC	TAGAGAACACGCTTC	TAGGAAAACCTTTAA
TTGGTCGAAGCGGCC	AGAGAACACGCTTCA	AGGAAAACCTTTAAA
TGGTCGAAGCGGCCG	GAGAACACGCTTCAC	GGAAAACCTTTAAAC
GGTCGAAGCGGCCGA	AGAACACGCTTCACC	GAAAACCTTTAAACC
GTCGAAGCGGCCGAC	GAACACGCTTCACCC	AAAACCTTTAAACCC
TCGAAGCGGCCGACC	AACACGCTTCACCCC	AAACCTTTAAACCCC
CGAAGCGGCCGACCA	ACACGCTTCACCCCC	AACCTTTAAACCCCG
GAAGCGGCCGACCAC	CACGCTTCACCCCCA	ACCTTTAAACCCCGG
AAGCGGCCGACCACT	ACGCTTCACCCCCAC	CCTTTAAACCCCGGT
AGCGGCCGACCACTG	CGCTTCACCCCCACT	CTTTAAACCCCGGTC
GCGGCCGACCACTGA	GCTTCACCCCCACTC	TTTAAACCCCGGTCA
CGGCCGACCACTGAC	CTTCACCCCCACTCC	TTAAACCCCGGTCAT
GGCCGACCACTGACT	TTCACCCCCACTCCC	TAAACCCCGGTCATC
GCCGACCACTGACTT	TCACCCCCACTCCCC	AAACCCCGGTCATCC
CCGACCACTGACTTT	CACCCCCACTCCCCG	AACCCCGGTCATCCG
CGACCACTGACTTTG	ACCCCCACTCCCCGT	ACCCCGGTCATCCGG
GACCACTGACTTTGT	CCCCCACTCCCCGTA	CCCCGGTCATCCGGA
ACCACTGACTTTGTG	CCCCACTCCCCGTAC	CCCGGTCATCCGGAC
CCACTGACTTTGTGA	CCCACTCCCCGTACA	CCGGTCATCCGGACA
CACTGACTTTGTGAC	CCACTCCCCGTACAG	CGGTCATCCGGACAT
ACTGACTTTGTGACT	CACTCCCCGTACAGT	GGTCATCCGGACATC
CTGACTTTGTGACTT	ACTCCCCGTACAGTG	GTCATCCGGACATCC
TGACTTTGTGACTTA	CTCCCCGTACAGTGC	TCATCCGGACATCCC
GACTTTGTGACTTAG	TCCCCGTACAGTGCG	CATCCGGACATCCCA
ATCCGGACATCCCAA	TGAAACAAGGGCGTG	TGTACTGCTTGGGGA
TCCGGACATCCCAAC	GAAACAAGGGCGTGG	GTACTGCTTGGGGAC
CCGGACATCCCAACG	AAACAAGGGCGTGGA	TACTGCTTGGGGACT
CGGACATCCCAACGC	AACAAGGGCGTGGAT	ACTGCTTGGGGACTA
GGACATCCCAACGCA	ACAAGGGCGTGGATC	CTGCTTGGGGACTAT
GACATCCCAACGCAT	CAAGGGCGTGGATCC	TGCTTGGGGACTATT
ACATCCCAACGCATG	AAGGGCGTGGATCCC	GCTTGGGGACTATTG
CATCCCAACGCATGC	AGGGCGTGGATCCCT	CTTGGGGACTATTGG
ATCCCAACGCATGCT	GGGCGTGGATCCCTC	TTGGGGACTATTGGA
TCCCAACGCATGCTC	GGCGTGGATCCCTCA	TGGGGACTATTGGAG
CCCAACGCATGCTCC	GCGTGGATCCCTCAA	GGGGACTATTGGAGA
CCAACGCATGCTCCT	CGTGGATCCCTCAAC	GGGACTATTGGAGAA
CAACGCATGCTCCTG	GTGGATCCCTCAACC	GGACTATTGGAGAAA
AACGCATGCTCCTGG	TGGATCCCTCAACCA	GACTATTGGAGAAAA
ACGCATGCTCCTGGA	GGATCCCTCAACCAA	ACTATTGGAGAAAAT
CGCATGCTCCTGGAG	GATCCCTCAACCAAG	CTATTGGAGAAAATA
GCATGCTCCTGGAGC	ATCCCTCAACCAAGA	TATTGGAGAAAATAA
CATGCTCCTGGAGCT	TCCCTCAACCAAGAA	ATTGGAGAAAATAAG
ATGCTCCTGGAGCTC	CCCTCAACCAAGAAG	TTGGAGAAAATAAGG
TGCTCCTGGAGCTCA	CCTCAACCAAGAAGA	TGGAGAAAATAAGGT
GCTCCTGGAGCTCAC	CTCAACCAAGAAGAA	GGAGAAAATAAGGTG
CTCCTGGAGCTCACA	TCAACCAAGAAGAAT	GAGAAAATAAGGTGG
TCCTGGAGCTCACAG	CAACCAAGAAGAATG	AGAAAATAAGGTGGA
CCTGGAGCTCACAGC	AACCAAGAAGAATGT	GAAAATAAGGTGGAG
CTGGAGCTCACAGCC	ACCAAGAAGAATGTT	AAAATAAGGTGGAGT
TGGAGCTCACAGCCT	CCAAGAAGAATGTTT	AAATAAGGTGGAGTC
GGAGCTCACAGCCTT	CAAGAAGAATGTTTA	AATAAGGTGGAGTCC
GAGCTCACAGCCTTC	AAGAAGAATGTTTAT	ATAAGGTGGAGTCCT
AGCTCACAGCCTTCT	AGAAGAATGTTTATG	TAAGGTGGAGTCCTA
GCTCACAGCCTTCTG	GAAGAATGTTTATGT	AAGGTGGAGTCCTAC
CTCACAGCCTTCTGT	AAGAATGTTTATGTC	AGGTGGAGTCCTACT
TCACAGCCTTCTGTG	AGAATGTTTATGTCT	GGTGGAGTCCTACTT
CACAGCCTTCTGTGG	GAATGTTTATGTCTT	GTGGAGTCCTACTTG
ACAGCCTTCTGTGGT	AATGTTTATGTCTTC	TGGAGTCCTACTTGT
CAGCCTTCTGTGGTG	ATGTTTATGTCTTCA	GGAGTCCTACTTGTT
AGCCTTCTGTGGTGT	TGTTTATGTCTTCAA	GAGTCCTACTTGTTT
GCCTTCTGTGGTGTC	GTTTATGTCTTCAAG	AGTCCTACTTGTTTA
CCTTCTGTGGTGTCA	TTTATGTCTTCAAGT	GTCCTACTTGTTTAA
CTTCTGTGGTGTCAT	TTATGTCTTCAAGTG	TCCTACTTGTTTAAA
TTCTGTGGTGTCATT	TATGTCTTCAAGTGA	CCTACTTGTTTAAAA
TCTGTGGTGTCATTT	ATGTCTTCAAGTGAC	CTACTTGTTTAAAAA
CTGTGGTGTCATTTC	TGTCTTCAAGTGACC	TACTTGTTTAAAAAA
TGTGGTGTCATTTCT	GTCTTCAAGTGACCT	ACTTGTTTAAAAAAT
GTGGTGTCATTTCTG	TCTTCAAGTGACCTG	CTTGTTTAAAAAATA
TGGTGTCATTTCTGA	CTTCAAGTGACCTGT	TTGTTTAAAAAATAT
GGTGTCATTTCTGAA	TTCAAGTGACCTGTA	TGTTTAAAAAATATG
GTGTCATTTCTGAAA	TCAAGTGACCTGTAC	GTTTAAAAAATATGT
TGTCATTTCTGAAAC	CAAGTGACCTGTACT	TTTAAAAAATATGTA
GTCATTTCTGAAACA	AAGTGACCTGTACTG	TTAAAAAATATGTAT
TCATTTCTGAAACAA	AGTGACCTGTACTGC	TAAAAAATATGTATC
CATTTCTGAAACAAG	GTGACCTGTACTGCT	AAAAAATATGTATCT
ATTTCTGAAACAAGG	TGACCTGTACTGCTT	AAAAATATGTATCTA
TTTCTGAAACAAGGG	GACCTGTACTGCTTG	AAAATATGTATCTAA
TTCTGAAACAAGGGC	ACCTGTACTGCTTGG	AAATATGTATCTAAG
TCTGAAACAAGGGCG	CCTGTACTGCTTGGG	AATATGTATCTAAGA
CTGAAACAAGGGCGT	CTGTACTGCTTGGGG	ATATGTATCTAAGAA
TATGTATCTAAGAAT	GGCCCTCCTCTTCAG	GCTTTTGCTGCGGCC
ATGTATCTAAGAATG	GCCCTCCTCTTCAGG	CTTTTGCTGCGGCCC
TGTATCTAAGAATGT	CCCTCCTCTTCAGGA	TTTTGCTGCGGCCCC
GTATCTAAGAATGTT	CCTCCTCTTCAGGAA	TTTGCTGCGGCCCCG
TATCTAAGAATGTTC	CTCCTCTTCAGGAAT	TTGCTGCGGCCCCGT
ATCTAAGAATGTTCT	TCCTCTTCAGGAATC	TGCTGCGGCCCCGTG
TCTAAGAATGTTCTA	CCTCTTCAGGAATCT	GCTGCGGCCCCGTGG
CTAAGAATGTTCTAG	CTCTTCAGGAATCTT	CTGCGGCCCCGTGGG
TAAGAATGTTCTAGG	TCTTCAGGAATCTTC	TGCGGCCCCGTGGGG
AAGAATGTTCTAGGG	CTTCAGGAATCTTCC	GCGGCCCCGTGGGGT
AGAATGTTCTAGGGC	TTCAGGAATCTTCCT	CGGCCCCGTGGGGTA
GAATGTTCTAGGGCA	TCAGGAATCTTCCTG	GGCCCCGTGGGGTAG
AATGTTCTAGGGCAC	CAGGAATCTTCCTGA	GCCCCGTGGGGTAGG
ATGTTCTAGGGCACT	AGGAATCTTCCTGAA	CCCCGTGGGGTAGGA
TGTTCTAGGGCACTC	GGAATCTTCCTGAAG	CCCGTGGGGTAGGAG
GTTCTAGGGCACTCT	GAATCTTCCTGAAGA	CCGTGGGGTAGGAGG
TTCTAGGGCACTCTG	AATCTTCCTGAAGAC	CGTGGGGTAGGAGGG
TCTAGGGCACTCTGG	ATCTTCCTGAAGACA	GTGGGGTAGGAGGGA
CTAGGGCACTCTGGG	TCTTCCTGAAGACAT	TGGGGTAGGAGGGAC
TAGGGCACTCTGGGA	CTTCCTGAAGACATG	GGGGTAGGAGGGACA
AGGGCACTCTGGGAA	TTCCTGAAGACATGG	GGGTAGGAGGGACAG
GGGCACTCTGGGAAC	TCCTGAAGACATGGC	GGTAGGAGGGACAGA
GGCACTCTGGGAACC	CCTGAAGACATGGCC	GTAGGAGGGACAGAG
GCACTCTGGGAACCT	CTGAAGACATGGCCC	TAGGAGGGACAGAGA
CACTCTGGGAACCTA	TGAAGACATGGCCCA	AGGAGGGACAGAGAG
ACTCTGGGAACCTAT	GAAGACATGGCCCAG	GGAGGGACAGAGAGA
CTCTGGGAACCTATA	AAGACATGGCCCAGT	GAGGGACAGAGAGAC
TCTGGGAACCTATAA	AGACATGGCCCAGTC	AGGGACAGAGAGACG
CTGGGAACCTATAAA	GACATGGCCCAGTCG	GGGACAGAGAGACGG
TGGGAACCTATAAAG	ACATGGCCCAGTCGA	GGACAGAGAGACGGG
GGGAACCTATAAAGG	CATGGCCCAGTCGAA	GACAGAGAGACGGGA
GGAACCTATAAAGGC	ATGGCCCAGTCGAAG	ACAGAGAGACGGGAG
GAACCTATAAAGGCA	TGGCCCAGTCGAAGG	CAGAGAGACGGGAGA
AACCTATAAAGGCAG	GGCCCAGTCGAAGGC	AGAGAGACGGGAGAG
ACCTATAAAGGCAGG	GCCCAGTCGAAGGCC	GAGAGACGGGAGAGT
CCTATAAAGGCAGGT	CCCAGTCGAAGGCCC	AGAGACGGGAGAGTC
CTATAAAGGCAGGTA	CCAGTCGAAGGCCCA	GAGACGGGAGAGTCA
TATAAAGGCAGGTAT	CAGTCGAAGGCCCAG	AGACGGGAGAGTCAG
ATAAAGGCAGGTATT	AGTCGAAGGCCCAGG	GACGGGAGAGTCAGC
TAAAGGCAGGTATTT	GTCGAAGGCCCAGGA	ACGGGAGAGTCAGCC
AAAGGCAGGTATTTC	TCGAAGGCCCAGGAT	CGGGAGAGTCAGCCT
AAGGCAGGTATTTCG	CGAAGGCCCAGGATG	GGGAGAGTCAGCCTC
AGGCAGGTATTTCGG	GAAGGCCCAGGATGG	GGAGAGTCAGCCTCC
GGCAGGTATTTCGGG	AAGGCCCAGGATGGC	GAGAGTCAGCCTCCA
GCAGGTATTTCGGGC	AGGCCCAGGATGGCT	AGAGTCAGCCTCCAC
CAGGTATTTCGGGCC	GGCCCAGGATGGCTT	GAGTCAGCCTCCACA
AGGTATTTCGGGCCC	GCCCAGGATGGCTTT	AGTCAGCCTCCACAT
GGTATTTCGGGCCCT	CCCAGGATGGCTTTT	GTCAGCCTCCACATT
GTATTTCGGGCCCTC	CCAGGATGGCTTTTG	TCAGCCTCCACATTC
TATTTCGGGCCCTCC	CAGGATGGCTTTTGC	CAGCCTCCACATTCA
ATTTCGGGCCCTCCT	AGGATGGCTTTTGCT	AGCCTCCACATTCAG
TTTCGGGCCCTCCTC	GGATGGCTTTTGCTG	GCCTCCACATTCAGA
TTCGGGCCCTCCTCT	GATGGCTTTTGCTGC	CCTCCACATTCAGAG
TCGGGCCCTCCTCTT	ATGGCTTTTGCTGCG	CTCCACATTCAGAGG
CGGGCCCTCCTCTTC	TGGCTTTTGCTGCGG	TCCACATTCAGAGGC
GGGCCCTCCTCTTCA	GGCTTTTGCTGCGGC	CCACATTCAGAGGCA
CACATTCAGAGGCAT	GTGTTTTGTAGTTCA	AAGGCAAAGCTTTAT
ACATTCAGAGGCATC	TGTTTTGTAGTTCAA	AGGCAAAGCTTTATT
CATTCAGAGGCATCA	GTTTTGTAGTTCAAC	GGCAAAGCTTTATTT
ATTCAGAGGCATCAC	TTTTGTAGTTCAACA	GCAAAGCTTTATTTT
TTCAGAGGCATCACA	TTTGTAGTTCAACAA	CAAAGCTTTATTTTC
TCAGAGGCATCACAA	TTGTAGTTCAACAAC	AAAGCTTTATTTTCA
CAGAGGCATCACAAG	TGTAGTTCAACAACT	AAGCTTTATTTTCAT
AGAGGCATCACAAGT	GTAGTTCAACAACTC	AGCTTTATTTTCATC
GAGGCATCACAAGTA	TAGTTCAACAACTCA	GCTTTATTTTCATCT
AGGCATCACAAGTAA	AGTTCAACAACTCAA	CTTTATTTTCATCTC
GGCATCACAAGTAAT	GTTCAACAACTCAAG	TTTATTTTCATCTCT
GCATCACAAGTAATG	TTCAACAACTCAAGA	TTATTTTCATCTCTC
CATCACAAGTAATGG	TCAACAACTCAAGAC	TATTTTCATCTCTCA
ATCACAAGTAATGGC	CAACAACTCAAGACG	ATTTTCATCTCTCAT
TCACAAGTAATGGCA	AACAACTCAAGACGA	TTTTCATCTCTCATC
CACAAGTAATGGCAC	ACAACTCAAGACGAA	TTTCATCTCTCATCT
ACAAGTAATGGCACA	CAACTCAAGACGAAG	TTCATCTCTCATCTT
CAAGTAATGGCACAA	AACTCAAGACGAAGC	TCATCTCTCATCTTT
AAGTAATGGCACAAT	ACTCAAGACGAAGCT	CATCTCTCATCTTTT
AGTAATGGCACAATT	CTCAAGACGAAGCTT	ATCTCTCATCTTTTG
GTAATGGCACAATTC	TCAAGACGAAGCTTA	TCTCTCATCTTTTGT
TAATGGCACAATTCT	CAAGACGAAGCTTAT	CTCTCATCTTTTGTC
AATGGCACAATTCTT	AAGACGAAGCTTATT	TCTCATCTTTTGTCC
ATGGCACAATTCTTC	AGACGAAGCTTATTT	CTCATCTTTTGTCCT
TGGCACAATTCTTCG	GACGAAGCTTATTTC	TCATCTTTTGTCCTC
GGCACAATTCTTCGG	ACGAAGCTTATTTCT	CATCTTTTGTCCTCC
GCACAATTCTTCGGA	CGAAGCTTATTTCTG	ATCTTTTGTCCTCCT
CACAATTCTTCGGAT	GAAGCTTATTTCTGA	TCTTTTGTCCTCCTT
ACAATTCTTCGGATG	AAGCTTATTTCTGAG	CTTTTGTCCTCCTTA
CAATTCTTCGGATGA	AGCTTATTTCTGAGG	TTTTGTCCTCCTTAG
AATTCTTCGGATGAC	GCTTATTTCTGAGGA	TTTGTCCTCCTTAGC
ATTCTTCGGATGACT	CTTATTTCTGAGGAT	TTGTCCTCCTTAGCA
TTCTTCGGATGACTG	TTATTTCTGAGGATA	TGTCCTCCTTAGCAC
TCTTCGGATGACTGC	TATTTCTGAGGATAA	GTCCTCCTTAGCACA
CTTCGGATGACTGCA	ATTTCTGAGGATAAG	TCCTCCTTAGCACAA
TTCGGATGACTGCAG	TTTCTGAGGATAAGC	CCTCCTTAGCACAAT
TCGGATGACTGCAGA	TTCTGAGGATAAGCT	CTCCTTAGCACAATG
CGGATGACTGCAGAA	TCTGAGGATAAGCTC	TCCTTAGCACAATGT
GGATGACTGCAGAAA	CTGAGGATAAGCTCT	CCTTAGCACAATGTA
GATGACTGCAGAAAA	TGAGGATAAGCTCTT	CTTAGCACAATGTAA
ATGACTGCAGAAAAT	GAGGATAAGCTCTTT	TTAGCACAATGTAAA
TGACTGCAGAAAATA	AGGATAAGCTCTTTA	TAGCACAATGTAAAA
GACTGCAGAAAATAG	GGATAAGCTCTTTAA	AGCACAATGTAAAAA
ACTGCAGAAAATAGT	GATAAGCTCTTTAAA	GCACAATGTAAAAAA
CTGCAGAAAATAGTG	ATAAGCTCTTTAAAG	CACAATGTAAAAAAG
TGCAGAAAATAGTGT	TAAGCTCTTTAAAGG	ACAATGTAAAAAAGA
GCAGAAAATAGTGTT	AAGCTCTTTAAAGGC	CAATGTAAAAAAGAA
CAGAAAATAGTGTTT	AGCTCTTTAAAGGCA	AATGTAAAAAAGAAT
AGAAAATAGTGTTTT	GCTCTTTAAAGGCAA	ATGTAAAAAAGAATA
GAAAATAGTGTTTTG	CTCTTTAAAGGCAAA	TGTAAAAAAGAATAG
AAAATAGTGTTTTGT	TCTTTAAAGGCAAAG	GTAAAAAAGAATAGT
AAATAGTGTTTTGTA	CTTTAAAGGCAAAGC	TAAAAAAGAATAGTA
AATAGTGTTTTGTAG	TTTAAAGGCAAAGCT	AAAAAAGAATAGTAA
ATAGTGTTTTGTAGT	TTAAAGGCAAAGCTT	AAAAAGAATAGTAAT
TAGTGTTTTGTAGTT	TAAAGGCAAAGCTTT	AAAAGAATAGTAATA
AGTGTTTTGTAGTTC	AAAGGCAAAGCTTTA	AAAGAATAGTAATAT
AAGAATAGTAATATC	GACACTGGGAGCACA	TGCTTTTCTTTATAA
AGAATAGTAATATCA	ACACTGGGAGCACAT	GCTTTTCTTTATAAT
GAATAGTAATATCAG	CACTGGGAGCACATA	CTTTTCTTTATAATT
AATAGTAATATCAGA	ACTGGGAGCACATAG	TTTTCTTTATAATTC
ATAGTAATATCAGAA	CTGGGAGCACATAGA	TTTCTTTATAATTCA
TAGTAATATCAGAAC	TGGGAGCACATAGAG	TTCTTTATAATTCAC
AGTAATATCAGAACA	GGGAGCACATAGAGA	TCTTTATAATTCACA
GTAATATCAGAACAG	GGAGCACATAGAGAT	CTTTATAATTCACAC
TAATATCAGAACAGG	GAGCACATAGAGATT	TTTATAATTCACACA
AATATCAGAACAGGA	AGCACATAGAGATTC	TTATAATTCACACAT
ATATCAGAACAGGAA	GCACATAGAGATTCA	TATAATTCACACATA
TATCAGAACAGGAAG	CACATAGAGATTCAC	ATAATTCACACATAT
ATCAGAACAGGAAGG	ACATAGAGATTCACC	TAATTCACACATATA
TCAGAACAGGAAGGA	CATAGAGATTCACCC	AATTCACACATATAT
CAGAACAGGAAGGAG	ATAGAGATTCACCCA	ATTCACACATATATG
AGAACAGGAAGGAGG	TAGAGATTCACCCAT	TTCACACATATATGC
GAACAGGAAGGAGGA	AGAGATTCACCCATG	TCACACATATATGCA
AACAGGAAGGAGGAA	GAGATTCACCCATGT	CACACATATATGCAG
ACAGGAAGGAGGAAT	AGATTCACCCATGTT	ACACATATATGCAGA
CAGGAAGGAGGAATG	GATTCACCCATGTTT	CACATATATGCAGAG
AGGAAGGAGGAATGG	ATTCACCCATGTTTG	ACATATATGCAGAGA
GGAAGGAGGAATGGC	TTCACCCATGTTTGT	CATATATGCAGAGAA
GAAGGAGGAATGGCT	TCACCCATGTTTGTT	ATATATGCAGAGAAG
AAGGAGGAATGGCTT	CACCCATGTTTGTTG	TATATGCAGAGAAGA
AGGAGGAATGGCTTG	ACCCATGTTTGTTGA	ATATGCAGAGAAGAT
GGAGGAATGGCTTGC	CCCATGTTTGTTGAA	TATGCAGAGAAGATA
GAGGAATGGCTTGCT	CCATGTTTGTTGAAC	ATGCAGAGAAGATAT
AGGAATGGCTTGCTG	CATGTTTGTTGAACT	TGAGAGAAGATATG
GGAATGGCTTGCTGG	ATGTTTGTTGAACTT	GCAGAGAAGATATGT
GAATGGCTTGCTGGG	TGTTTGTTGAACTTA	CAGAGAAGATATGTT
AATGGCTTGCTGGGG	GTTTGTTGAACTTAG	AGAGAAGATATGTTC
ATGGCTTGCTGGGGA	TTTGTTGAACTTAGA	GAGAAGATATGTTCT
TGGCTTGCTGGGGAG	TTGTTGAACTTAGAG	AGAAGATATGTTCTT
GGCTTGCTGGGGAGC	TGTTGAACTTAGAGT	GAAGATATGTTCTTG
GCTTGCTGGGGAGCC	GTTGAACTTAGAGTC	AAGATATGTTCTTGT
CTTGCTGGGGAGCCC	TTGAACTTAGAGTCA	AGATATGTTCTTGTT
TTGCTGGGGAGCCCA	TGAACTTAGAGTCAT	GATATGTTCTTGTTA
TGCTGGGGAGCCCAT	GAACTTAGAGTCATT	ATATGTTCTTGTTAA
GCTGGGGAGCCCATC	AACTTAGAGTCATTC	TATGTTCTTGTTAAC
CTGGGGAGCCCATCC	ACTTAGAGTCATTCT	ATGTTCTTGTTAACA
TGGGGAGCCCATCCA	CTTAGAGTCATTCTC	TGTTCTTGTTAACAT
GGGGAGCCCATCCAG	TTAGAGTCATTCTCA	GTTCTTGTTAACATT
GGGAGCCCATCCAGG	TAGAGTCATTCTCAT	TTCTTGTTAACATTG
GGAGCCCATCCAGGA	AGAGTCATTCTCATG	TCTTGTTAACATTGT
GAGCCCATCCAGGAC	GAGTCATTCTCATGC	CTTGTTAACATTGTA
AGCCCATCCAGGACA	AGTCATTCTCATGCT	TTGTTAACATTGTAT
GCCCATCCAGGACAC	GTCATTCTCATGCTT	TGTTAACATTGTATA
CCCATCCAGGACACT	TCATTCTCATGCTTT	GTTAACATTGTATAC
CCATCCAGGACACTG	CATTCTCATGCTTTT	TTAACATTGTATACA
CATCCAGGACACTGG	ATTCTCATGCTTTTC	TAACATTGTATACAA
ATCCAGGACACTGGG	TTCTCATGCTTTTCT	AACATTGTATACAAC
TCCAGGACACTGGGA	TCTCATGCTTTTCTT	ACATTGTATACAACA
CCAGGACACTGGGAG	CTCATGCTTTTCTTT	CATTGTATACAACAT
CAGGACACTGGGAGC	TCATGCTTTTCTTTA	ATTGTATACAACATA
AGGACACTGGGAGCA	CATGCTTTTCTTTAT	TTGTATACAACATAG
GGACACTGGGAGCAC	ATGCTTTTCTTTATA	TGTATACAACATAGC
GTATACAACATAGCC	TGTTAGAGATGCTAT	CCAGAGACTGGGCTG
TATACAACATAGCCC	GTTAGAGATGCTATA	CAGAGACTGGGCTGC
ATACAACATAGCCCC	TTAGAGATGCTATAT	AGAGACTGGGCTGCT
TACAACATAGCCCCA	TAGAGATGCTATATG	GAGACTGGGCTGCTC
ACAACATAGCCCCAA	AGAGATGCTATATGA	AGACTGGGCTGCTCT
CAACATAGCCCCAAA	GAGATGCTATATGAT	GACTGGGCTGCTCTC
AACATAGCCCCAAAT	AGATGCTATATGATA	ACTGGGCTGCTCTCC
ACATAGCCCCAAATA	GATGCTATATGATAC	CTGGGCTGCTCTCCC
CATAGCCCCAAATAT	ATGCTATATGATACA	TGGGCTGCTCTCCCG
ATAGCCCCAAATATA	TGCTATATGATACAA	GGGCTGCTCTCCCGG
TAGCCCCAAATATAG	GCTATATGATACAAC	GGCTGCTCTCCCGGA
AGCCCCAAATATAGT	CTATATGATACAACT	GCTGCTCTCCCGGAG
GCCCCAAATATAGTA	TATATGATACAACTG	CTGCTCTCCCGGAGG
CCCCAAATATAGTAA	ATATGATACAACTGT	TGCTCTCCCGGAGGC
CCCAAATATAGTAAG	TATGATACAACTGTG	GCTCTCCCGGAGGCC
CCAAATATAGTAAGA	ATGATACAACTGTGG	CTCTCCCGGAGGCCA
CAAATATAGTAAGAT	TGATACAACTGTGGC	TCTCCCGGAGGCCAA
AAATATAGTAAGATC	GATACAACTGTGGCC	CTCCCGGAGGCCAAA
AATATAGTAAGATCT	ATACAACTGTGGCCA	TCCCGGAGGCCAAAC
ATATAGTAAGATCTA	TACAACTGTGGCCAT	CCCGGAGGCCAAACC
TATAGTAAGATCTAT	ACAACTGTGGCCATG	CCGGAGGCCAAACCC
ATAGTAAGATCTATA	CAACTGTGGCCATGA	CGGAGGCCAAACCCA
TAGTAAGATCTATAC	AACTGTGGCCATGAC	GGAGGCCAAACCCAA
AGTAAGATCTATACT	ACTGTGGCCATGACT	GAGGCCAAACCCAAG
GTAAGATCTATACTA	CTGTGGCCATGACTG	AGGCCAAACCCAAGA
TAAGATCTATACTAG	TGTGGCCATGACTGA	GGCCAAACCCAAGAA
AAGATCTATACTAGA	GTGGCCATGACTGAG	GCCAAACCCAAGAAG
AGATCTATACTAGAT	TGGCCATGACTGAGG	CCAAACCCAAGAAGG
GATCTATACTAGATA	GGCCATGACTGAGGA	CAAACCCAAGAAGGT
ATCTATACTAGATAA	GCCATGACTGAGGAA	AAACCCAAGAAGGTC
TCTATACTAGATAAT	CCATGACTGAGGAAA	AACCCAAGAAGGTCT
CTATACTAGATAATC	CATGACTGAGGAAAG	ACCCAAGAAGGTCTG
TATACTAGATAATCC	ATGACTGAGGAAAGG	CCCAAGAAGGTCTGG
ATACTAGATAATCCT	TGACTGAGGAAAGGA	CCAAGAAGGTCTGGC
TACTAGATAATCCTA	GACTGAGGAAAGGAG	CAAGAAGGTCTGGCA
ACTAGATAATCCTAG	ACTGAGGAAAGGAGC	AAGAAGGTCTGGCAA
CTAGATAATCCTAGA	CTGAGGAAAGGAGCT	AGAAGGTCTGGCAAA
TAGATAATCCTAGAT	TGAGGAAAGGAGCTC	GAAGGTCTGGCAAAG
AGATAATCCTAGATG	GAGGAAAGGAGCTCA	AAGGTCTGGCAAAGT
GATAATCCTAGATGA	AGGAAAGGAGCTCAC	AGGTCTGGCAAAGTC
ATAATCCTAGATGAA	GGAAAGGAGCTCACG	GGTCTGGCAAAGTCA
TAATCCTAGATGAAA	GAAAGGAGCTCACGC	GTCTGGCAAAGTCAG
AATCCTAGATGAAAT	AAAGGAGCTCACGCC	TCTGGCAAAGTCAGG
ATCCTAGATGAAATG	AAGGAGCTCACGCCC	CTGGCAAAGTCAGGC
TCCTAGATGAAATGT	AGGAGCTCACGCCCA	TGGCAAAGTCAGGCT
CCTAGATGAAATGTT	GGAGCTCACGCCCAG	GGCAAAGTCAGGCTC
CTAGATGAAATGTTA	GAGCTCACGCCCAGA	GCAAAGTCAGGCTCA
TAGATGAAATGTTAG	AGCTCACGCCCAGAG	CAAAGTCAGGCTCAG
AGATGAAATGTTAGA	GCTCACGCCCAGAGA	AAAGTCAGGCTCAGG
GATGAAATGTTAGAG	CTCACGCCCAGAGAC	AAGTCAGGCTCAGGG
ATGAAATGTTAGAGA	TCACGCCCAGAGACT	AGTCAGGCTCAGGGA
TGAAATGTTAGAGAT	CACGCCCAGAGACTG	GTCAGGCTCAGGGAG
GAAATGTTAGAGATG	ACGCCCAGAGACTGG	TCAGGCTCAGGGAGA
AAATGTTAGAGATGC	CGCCCAGAGACTGGG	CAGGCTCAGGGAGAC
AATGTTAGAGATGCT	GCCCAGAGACTGGGC	AGGCTCAGGGAGACT
ATGTTAGAGATGCTA	CCCAGAGACTGGGCT	GGCTCAGGGAGACTC
GCTCAGGGAGACTCT	CTCTCCTTGAAAACA	TATTTTTTTAACTTT
CTCAGGGAGACTCTG	TCTCCTTGAAAACAG	ATTTTTTTAACTTTT
TCAGGGAGACTCTGC	CTCCTTGAAAACAGA	TTTTTTTAACTTTTT
CAGGGAGACTCTGCC	TCCTTGAAAACAGAG	TTTTTTAACTTTTTG
AGGGAGACTCTGCCC	CCTTGAAAACAGAGG	TTTTTAACTTTTTGG
GGGAGACTCTGCCCT	CTTGAAAACAGAGGG	TTTTAACTTTTTGGG
GGAGACTCTGCCCTG	TTGAAAACAGAGGGG	TTTAACTTTTTGGGG
GAGACTCTGCCCTGC	TGAAAACAGAGGGGT	TTAACTTTTTGGGGG
AGACTCTGCCCTGCT	GAAAACAGAGGGGTC	TAACTTTTTGGGGGG
GACTCTGCCCTGCTG	AAAACAGAGGGGTCT	AACTTTTTGGGGGGA
ACTCTGCCCTGCTGC	AAACAGAGGGGTCTC	ACTTTTTGGGGGGAA
CTCTGCCCTGCTGCA	AACAGAGGGGTCTCA	CTTTTTGGGGGGAAA
TCTGCCCTGCTGCAG	ACAGAGGGGTCTCAA	TTTTTGGGGGGAAAA
CTGCCCTGCTGCAGA	CAGAGGGGTCTCAAG	TTTTGGGGGGAAAAG
TGCCCTGCTGCAGAC	AGAGGGGTCTCAAGA	TTTGGGGGGAAAAGT
GCCCTGCTGCAGACC	GAGGGGTCTCAAGAC	TTGGGGGGAAAAGTA
CCCTGCTGCAGACCT	AGGGGTCTCAAGACA	TGGGGGGAAAAGTAT
CCTGCTGCAGACCTC	GGGGTCTCAAGACAT	GGGGGGAAAAGTATT
CTGCTGCAGACCTCG	GGGTCTCAAGACATT	GGGGGAAAAGTATTT
TGCTGCAGACCTCGG	GGTCTCAAGACATTC	GGGGAAAAGTATTTT
GCTGCAGACCTCGGT	GTCTCAAGACATTCT	GGGAAAAGTATTTTT
CTGCAGACCTCGGTG	TCTCAAGACATTCTG	GGAAAAGTATTTTTG
TGCAGACCTCGGTGT	CTCAAGACATTCTGC	GAAAAGTATTTTTGA
GCAGACCTCGGTGTG	TCAAGACATTCTGCC	AAAAGTATTTTTGAG
CAGACCTCGGTGTGG	CAAGACATTCTGCCT	AAAGTATTTTTGAGA
AGACCTCGGTGTGGA	AAGACATTCTGCCTA	AAGTATTTTTGAGAA
GACCTCGGTGTGGAC	AGACATTCTGCCTAC	AGTATTTTTGAGAAG
ACCTCGGTGTGGACA	GACATTCTGCCTACC	GTATTTTTGAGAAGT
CCTCGGTGTGGACAC	ACATTCTGCCTACCT	TATTTTTGAGAAGTT
CTCGGTGTGGACACA	CATTCTGCCTACCTA	ATTTTTGAGAAGTTT
TCGGTGTGGACACAC	ATTCTGCCTACCTAT	TTTTTGAGAAGTTTG
CGGTGTGGACACACG	TTCTGCCTACCTATT	TTTTGAGAAGTTTGT
GGTGTGGACACACGC	TCTGCCTACCTATTA	TTTGAGAAGTTTGTC
GTGTGGACACACGCT	CTGCCTACCTATTAG	TTGAGAAGTTTGTCT
TGTGGACACACGCTG	TGCCTACCTATTAGC	TGAGAAGTTTGTCTT
GTGGACACACGCTGC	GCCTACCTATTAGCT	GAGAAGTTTGTCTTG
TGGACACACGCTGCA	CCTACCTATTAGCTT	AGAAGTTTGTCTTGC
GGACACACGCTGCAT	CTACCTATTAGCTTT	GAAGTTTGTCTTGCA
GACACACGCTGCATA	TACCTATTAGCTTTT	AAGTTTGTCTTGCAA
ACACACGCTGCATAG	ACCTATTAGCTTTTC	AGTTTGTCTTGCAAT
CACACGCTGCATAGA	CCTATTAGCTTTTCT	GTTTGTCTTGCAATG
ACACGCTGCATAGAG	CTATTAGCTTTTCTT	TTTGTCTTGCAATGT
CACGCTGCATAGAGC	TATTAGCTTTTCTTT	TTGTCTTGCAATGTA
ACGCTGCATAGAGCT	ATTAGCTTTTCTTTA	TGTCTTGCAATGTAT
CGCTGCATAGAGCTC	TTAGCTTTTCTTTAT	GTCTTGCAATGTATT
GCTGCATAGAGCTCT	TAGCTTTTCTTTATT	TCTTGCAATGTATTT
CTGCATAGAGCTCTC	AGCTTTTCTTTATTT	CTTGCAATGTATTTA
TGCATAGAGCTCTCC	GCTTTTCTTTATTTT	TTGCAATGTATTTAT
GCATAGAGCTCTCCT	CTTTTCTTTATTTTT	TGCAATGTATTTATA
CATAGAGCTCTCCTT	TTTTCTTTATTTTTT	GCAATGTATTTATAA
ATAGAGCTCTCCTTG	TTTCTTTATTTTTTT	CAATGTATTTATAAA
TAGAGCTCTCCTTGA	TTCTTTATTTTTTTA	AATGTATTTATAAAT
AGAGCTCTCCTTGAA	TCTTTATTTTTTTAA	ATGTATTTATAAATA
GAGCTCTCCTTGAAA	CTTTATTTTTTTAAC	TGTATTTATAAATAG
AGCTCTCCTTGAAAA	TTTATTTTTTTAACT	GTATTTATAAATAGT
GCTCTCCTTGAAAAC	TTATTTTTTTAACTT	TATTTATAAATAGTA
ATTTATAAATAGTAA
TTTATAAATAGTAAA
TTATAAATAGTAAAT
TATAAATAGTAAATA
ATAAATAGTAAATAA
TAAATAGTAAATAAA
AAATAGTAAATAAAG
AATAGTAAATAAAGT
ATAGTAAATAAAGTT
TAGTAAATAAAGTTT
AGTAAATAAAGTTTT
GTAAATAAAGTTTTT
TAAATAAAGTTTTTA
AAATAAAGTTTTTAC
AATAAAGTTTTTACC
ATAAAGTTTTTACCA
TAAAGTTTTTACCAT
AAAGTTTTTACCATT

EXAMPLE 8

Antisense Oligonucleotides of IGF-I Receptor

[0058] Antisense oligonucleotides to IGF-I may selected from molecules capable of interacting with one or the following sense oligonucleotides:

TTTTTTTTTTTTTTG	TCATCCCAAATAAAA	GGCTCCGGAGGAGGG
TTTTTTTTTTTTTGA	CATCCCAAATAAAAG	GCTCCGGAGGAGGGT
TTTTTTTTTTTTGAG	ATCCCAAATAAAAGG	CTCCGGAGGAGGGTC
TTTTTTTTTTTGAGA	TCCCAAATAAAAGGA	TCCGGAGGAGGGTCC
TTTTTTTTTTGAGAA	CCCAAATAAAAGGAA	CCGGAGGAGGGTCCC
TTTTTTTTTGAGAAA	CCAAATAAAAGGAAT	CGGAGGAGGGTCCCC
TTTTTTTTGAGAAAG	CAAATAAAAGGAATG	GGAGGAGGGTCCCCG
TTTTTTTGAGAAAGG	AAATAAAAGGAATGA	GAGGAGGGTCCCCGA
TTTTTTGAGAAAGGG	AATAAAAGGAATGAA	AGGAGGGTCCCCGAC
TTTTTGAGAAAGGGA	ATAAAAGGAATGAAG	GGAGGGTCCCCGACC
TTTTGAGAAAGGGAA	TAAAAGGAATGAAGT	GAGGGTCCCCGACCT
TTTGAGAAAGGGAAT	AAAAGGAATGAAGTC	AGGGTCCCCGACCTC
TTGAGAAAGGGAATT	AAAGGAATGAAGTCT	GGGTCCCCGACCTCG
TGAGAAAGGGAATTT	AAGGAATGAAGTCTG	GGTCCCCGACCTCGC
GAGAAAGGGAATTTC	AGGAATGAAGTCTGG	GTCCCCGACCTCGCT
AGAAAGGGAATTTCA	GGAATGAAGTCTGGC	TCCCCGACCTCGCTG
GAAAGGGAATTTCAT	GAATGAAGTCTGGCT	CCCCGACCTCGCTGT
AAAGGGAATTTCATC	AATGAAGTCTGGCTC	CCCGACCTCGCTGTG
AAGGGAATTTCATCC	ATGAAGTCTGGCTCC	CCGACCTCGCTGTGG
AGGGAATTTCATCCC	TGAAGTCTGGCTCCG	CGACCTCGCTGTGGG
GGGAATTTCATCCCA	GAAGTCTGGCTCCGG	GACCTCGCTGTGGGG
GGAATTTCATCCCAA	AAGTCTGGCTCCGGA	ACCTCGCTGTGGGGG
GAATTTCATCCCAAA	AGTCTGGCTCCGGAG	CCTCGCTGTGGGGGC
AATTTCATCCCAAAT	GTCTGGCTCCGGAGG	CTCGCTGTGGGGGCT
ATTTCATCCCAAATA	TCTGGCTCCGGAGGA	TCGCTGTGGGGGCTC
TTTCATCCCAAATAA	CTGGCTCCGGAGGAG	CGCTGTGGGGGCTCC
TTCATCCCAAATAAA	TGGCTCCGGAGGAGG	GCTGTGGGGGCTCCT
CTGTGGGGGCTCCTG	AATCTGCGGGCCAGG	AGAACTGCACGGTGA
TGTGGGGGCTCCTGT	ATCTGCGGGCCAGGC	GAACTGCACGGTGAT
GTGGGGGCTCCTGTT	TCTGCGGGCCAGGCA	AACTGCACGGTGATC
TGGGGGCTCCTGTTT	CTGCGGGCCAGGCAT	ACTGCACGGTGATCG
GGGGGCTCCTGTTTC	TGCGGGCCAGGCATC	CTGCACGGTGATCGA
GGGGCTCCTGTTTCT	GCGGGCCAGGCATCG	TGCACGGTGATCGAG
GGGCTCCTGTTTCTC	CGGGCCAGGCATCGA	GCACGGTGATCGAGG
GGCTCCTGTTTCTCT	GGGCCAGGCATCGAC	CACGGTGATCGAGGG
GCTCCTGTTTCTCTC	GGCCAGGCATCGACA	ACGGTGATCGAGGGC
CTCCTGTTTCTCTCC	GCCAGGCATCGACAT	CGGTGATCGAGGGCT
TCCTGTTTCTCTCCG	CCAGGCATCGACATC	GGTGATCGAGGGCTA
CCTGTTTCTCTCCGC	CAGGCATCGACATCC	GTGATCGAGGGCTAC
CTGTTTCTCTCCGCC	AGGCATCGACATCCG	TGATCGAGGGCTACC
TGTTTCTCTCCGCCG	GGCATCGACATCCGC	GATCGAGGGCTACCT
GTTTCTCTCCGCCGC	GCATCGACATCCGCA	ATCGAGGGCTACCTC
TTTCTCTCCGCCGCG	CATCGACATCCGCAA	TCGAGGGCTACCTCC
TTCTCTCCGCCGCGC	ATCGACATCCGCAAC	CGAGGGCTACCTCCA
TCTCTCCGCCGCGCT	TCGACATCCGCAACG	GAGGGCTACCTCCAC
CTCTCCGCCGCGCTC	CGACATCCGCAACGA	AGGGCTACCTCCACA
TCTCCGCCGCGCTCT	GACATCCGCAACGAC	GGGCTACCTCCACAT
CTCCGCCGCGCTCTC	ACATCCGCAACGACT	GGCTACCTCCACATC
TCCGCCGCGCTCTCG	CATCCGCAACGACTA	GCTACCTCCACATCC
CCGCCGCGCTCTCGC	ATCCGCAACGACTAT	CTACCTCCACATCCT
CGCCGCGCTCTCGCT	TCCGCAACGACTATC	TACCTCCACATCCTG
GCCGCGCTCTCGCTC	CCGCAACGACTATCA	ACCTCCACATCCTGC
CCGCGCTCTCGCTCT	CGCAACGACTATCAG	CCTCCACATCCTGCT
CGCGCTCTCGCTCTG	GCAACGACTATCAGC	CTCCACATCCTGCTC
GCGCTCTCGCTCTGG	CAACGACTATCAGCA	TCCACATCCTGCTCA
CGCTCTCGCTCTGGC	AACGACTATCAGCAG	CCACATCCTGCTCAT
GCTCTCGCTCTGGCC	ACGACTATCAGCAGC	CACATCCTGCTCATC
CTCTCGCTCTGGCCG	CGACTATCAGCAGCT	ACATCCTGCTCATCT
TCTCGCTCTGGCCGA	GACTATCAGCAGCTG	CATCCTGCTCATCTC
CTCGCTCTGGCCGAC	ACTATCAGCAGCTGA	ATCCTGCTCATCTCC
TCGCTCTGGCCGACG	CTATCAGCAGCTGAA	TCCTGCTCATCTCCA
CGCTCTGGCCGACGA	TATCAGCAGCTGAAG	CCTGCTCATCTCCAA
GCTCTGGCCGACGAG	ATCAGCAGCTGAAGC	CTGCTCATCTCCAAG
CTCTGGCCGACGAGT	TCAGCAGCTGAAGCG	TGCTCATCTCCAAGG
TCTGGCCGACGAGTG	CAGCAGCTGAAGCGC	GCTCATCTCCAAGGC
CTGGCCGACGAGTGG	AGCAGCTGAAGCGCC	CTCATCTCCAAGGCC
TGGCCGACGAGTGGA	GCAGCTGAAGCGCCT	TCATCTCCAAGGCCG
GGCCGACGAGTGGAG	CAGCTGAAGCGCCTG	CATCTCCAAGGCCGA
GCCGACGAGTGGAGA	AGCTGAAGCGCCTGG	ATCTCCAAGGCCGAG
CCGACGAGTGGAGAA	GCTGAAGCGCCTGGA	TCTCCAAGGCCGAGG
CGACGAGTGGAGAAA	CTGAAGCGCCTGGAG	CTCCAAGGCCGAGGA
GACGAGTGGAGAAAT	TGAAGCGCCTGGAGA	TCCAAGGCCGAGGAC
ACGAGTGGAGAAATC	GAAGCGCCTGGAGAA	CCAAGGCCGAGGACT
CGAGTGGAGAAATCT	AAGCGCCTGGAGAAC	CAAGGCCGAGGACTA
GAGTGGAGAAATCTG	AGCGCCTGGAGAACT	AAGGCCGAGGACTAC
AGTGGAGAAATCTGC	GCGCCTGGAGAACTG	AGGCCGAGGACTACC
GTGGAGAAATCTGCG	CGCCTGGAGAACTGC	GGCCGAGGACTACCG
TGGAGAAATCTGCGG	GCCTGGAGAACTGCA	GCCGAGGACTACCGC
GGAGAAATCTGCGGG	CCTGGAGAACTGCAC	CCGAGGACTACCGCA
GAGAAATCTGCGGGC	CTGGAGAACTGCACG	CGAGGACTACCGCAG
AGAAATCTGCGGGCC	TGGAGAACTGCACGG	GAGGACTACCGCAGC
GAAATCTGCGGGCCA	GGAGAACTGCACGGT	AGGACTACCGCAGCT
AAATCTGCGGGCCAG	GAGAACTGCACGGTG	GGACTACCGCAGCTA
GACTACCGCAGCTAC	GTTCCGAGTGGCTGG	TCCGCGGCTGGAAAC
ACTACCGCAGCTACC	TTCCGAGTGGCTGGC	CCGCGGCTGGAAACT
CTACCGCAGCTACCG	TCCGAGTGGCTGGCC	CGCGGCTGGAAACTC
TACCGCAGCTACCGC	CCGAGTGGCTGGCCT	GCGGCTGGAAACTCT
ACCGCAGCTACCGCT	CGAGTGGCTGGCCTC	CGGCTGGAAACTCTT
CCGCAGCTACCGCTT	GAGTGGCTGGCCTCG	GGCTGGAAACTCTTC
CGCAGCTACCGCTTC	AGTGGCTGGCCTCGA	GCTGGAAACTCTTCT
GCAGCTACCGCTTCC	GTGGCTGGCCTCGAG	CTGGAAACTCTTCTA
CAGCTACCGCTTCCC	TGGCTGGCCTCGAGA	TGGAAACTCTTCTAC
AGCTACCGCTTCCCC	GGCTGGCCTCGAGAG	GGAAACTCTTCTACA
GCTACCGCTTCCCCA	GCTGGCCTCGAGAGC	GAAACTCTTCTACAA
CTACCGCTTCCCCAA	CTGGCCTCGAGAGCC	AAACTCTTCTACAAC
TACCGCTTCCCCAAG	TGGCCTCGAGAGCCT	AACTCTTCTACAACT
ACCGCTTCCCCAAGC	GGCCTCGAGAGCCTC	ACTCTTCTACAACTA
CCGCTTCCCCAAGCT	GCCTCGAGAGCCTCG	CTCTTCTACAACTAC
CGCTTCCCCAAGCTC	CCTCGAGAGCCTCGG	TCTTCTACAACTACG
GCTTCCCCAAGCTCA	CTCGAGAGCCTCGGA	CTTCTACAACTACGC
CTTCCCCAAGCTCAC	TCGAGAGCCTCGGAG	TTCTACAACTACGCC
TTCCCCAAGCTCACG	CGAGAGCCTCGGAGA	TCTACAACTACGCCC
TCCCCAAGCTCACGG	GAGAGCCTCGGAGAC	CTACAACTACGCCCT
CCCCAAGCTCACGGT	AGAGCCTCGGAGACC	TACAACTACGCCCTG
CCCAAGCTCACGGTC	GAGCCTCGGAGACCT	ACAACTACGCCCTGG
CCAAGCTCACGGTCA	AGCCTCGGAGACCTC	CAACTACGCCCTGGT
CAAGCTCACGGTCAT	GCCTCGGAGACCTCT	AACTACGCCCTGGTC
AAGCTCACGGTCATT	CCTCGGAGACCTCTT	ACTACGCCCTGGTCA
AGCTCACGGTCATTA	CTCGGAGACCTCTTC	CTACGCCCTGGTCAT
GCTCACGGTCATTAC	TCGGAGACCTCTTCC	TACGCCCTGGTCATC
CTCACGGTCATTACC	CGGAGACCTCTTCCC	ACGCCCTGGTCATCT
TCACGGTCATTACCG	GGAGACCTCTTCCCC	CGCCCTGGTCATCTT
CACGGTCATTACCGA	GAGACCTCTTCCCCA	GCCCTGGTCATCTTC
ACGGTCATTACCGAG	AGACCTCTTCCCCAA	CCCTGGTCATCTTCG
CGGTCATTACCGAGT	GACCTCTTCCCCAAC	CCTGGTCATCTTCGA
GGTCATTACCGAGTA	ACCTCTTCCCCAACC	CTGGTCATCTTCGAG
GTCATTACCGAGTAC	CCTCTTCCCCAACCT	TGGTCATCTTCGAGA
TCATTACCGAGTACT	CTCTTCCCCAACCTC	GGTCATCTTCGAGAT
CATTACCGAGTACTT	TCTTCCCCAACCTCA	GTCATCTTCGAGATG
ATTACCGAGTACTTG	CTTCCCCAACCTCAC	TCATCTTCGAGATGA
TTACCGAGTACTTGC	TTCCCCAACCTCACG	CATCTTCGAGATGAC
TACCGAGTACTTGCT	TCCCCAACCTCACGG	ATCTTCGAGATGACC
ACCGAGTACTTGCTG	CCCCAACCTCACGGT	TCTTCGAGATGACCA
CCGAGTACTTGCTGC	CCCAACCTCACGGTC	CTTCGAGATGACCAA
CGAGTACTTGCTGCT	CCAACCTCACGGTCA	TTCGAGATGACCAAT
GAGTACTTGCTGCTG	CAACCTCACGGTCAT	TCGAGATGACCAATC
AGTACTTGCTGCTGT	AACCTCACGGTCATC	CGAGATGACCAATCT
GTACTTGCTGCTGTT	ACCTCACGGTCATCC	GAGATGACCAATCTC
TACTTGCTGCTGTTC	CCTCACGGTCATCCG	AGATGACCAATCTCA
ACTTGCTGCTGTTCC	CTCACGGTCATCCGC	GATGACCAATCTCAA
CTTGCTGCTGTTCCG	TCACGGTCATCCGCG	ATGACCAATCTCAAG
TTGCTGCTGTTCCGA	CACGGTCATCCGCGG	TGACCAATCTCAAGG
TGCTGCTGTTCCGAG	ACGGTCATCCGCGGC	GACCAATCTCAAGGA
GCTGCTGTTCCGAGT	CGGTCATCCGCGGCT	ACCAATCTCAAGGAT
CTGCTGTTCCGAGTG	GGTCATCCGCGGCTG	CCAATCTCAAGGATA
TGCTGTTCCGAGTGG	GTCATCCGCGGCTGG	CAATCTCAAGGATAT
GCTGTTCCGAGTGGC	TCATCCGCGGCTGGA	AATCTCAAGGATATT
CTGTTCCGAGTGGCT	CATCCGCGGCTGGAA	ATCTCAAGGATATTG
TGTTCCGAGTGGCTG	ATCCGCGGCTGGAAA	TCTCAAGGATATTGG
CTCAAGGATATTGGG	TGAGAAAAATGCTGA	ATGCGGTGTCCAATA
TCAAGGATATTGGGC	GAGAAAAATGCTGAC	TGCGGTGTCCAATAA
CAAGGATATTGGGCT	AGAAAAATGCTGACC	GCGGTGTCCAATAAC
AAGGATATTGGGCTT	GAAAAATGCTGACCT	CGGTGTCCAATAACT
AGGATATTGGGCTTT	AAAAATGCTGACCTC	GGTGTCCAATAACTA
GGATATTGGGCTTTA	AAAATGCTGACCTCT	GTGTCCAATAACTAC
GATATTGGGCTTTAC	AAATGCTGACCTCTG	TGTCCAATAACTACA
ATATTGGGCTTTACA	AATGCTGACCTCTGT	GTCCAATAACTACAT
TATTGGGCTTTACAA	ATGCTGACCTCTGTT	TCCAATAACTACATT
ATTGGGCTTTACAAC	TGCTGACCTCTGTTA	CCAATAACTACATTG
TTGGGCTTTACAACC	GCTGACCTCTGTTAC	CAATAACTACATTGT
TGGGCTTTACAACCT	CTGACCTCTGTTACC	AATAACTACATTGTG
GGGCTTTACAACCTG	TGACCTCTGTTACCT	ATAACTACATTGTGG
GGCTTTACAACCTGA	GACCTCTGTTACCTC	TAACTACATTGTGGG
GCTTTACAACCTGAG	ACCTCTGTTACCTCT	AACTACATTGTGGGG
CTTTACAACCTGAGG	CCTCTGTTACCTCTC	ACTACATTGTGGGGA
TTTACAACCTGAGGA	CTCTGTTACCTCTCC	CTACATTGTGGGGAA
TTACAACCTGAGGAA	TCTGTTACCTCTCCA	TACATTGTGGGGAAT
TACAACCTGAGGAAC	CTGTTACCTCTCCAC	ACATTGTGGGGAATA
ACAACCTGAGGAACA	TGTTACCTCTCCACT	CATTGTGGGGAATAA
CAACCTGAGGAACAT	GTTACCTCTCCACTG	ATTGTGGGGAATAAG
AACCTGAGGAACATT	TTACCTCTCCACTGT	TTGTGGGGAATAAGC
ACCTGAGGAACATTA	TACCTCTCCACTGTG	TGTGGGGAATAAGCC
CCTGAGGAACATTAC	ACCTCTCCACTGTGG	GTGGGGAATAAGCCC
CTGAGGAACATTACT	CCTCTCCACTGTGGA	TGGGGAATAAGCCCC
TGAGGAACATTACTC	CTCTCCACTGTGGAC	GGGGAATAAGCCCCC
GAGGAACATTACTCG	TCTCCACTGTGGACT	GGGAATAAGCCCCCA
AGGAACATTACTCGG	CTCCACTGTGGACTG	GGAATAAGCCCCCAA
GGAACATTACTCGGG	TCCACTGTGGACTGG	GAATAAGCCCCCAAA
GAACATTACTCGGGG	CCACTGTGGACTGGT	AATAAGCCCCCAAAG
AACATTACTCGGGGG	CACTGTGGACTGGTC	ATAAGCCCCCAAAGG
ACATTACTCGGGGGG	ACTGTGGACTGGTCC	TAAGCCCCCAAAGGA
CATTACTCGGGGGGC	CTGTGGACTGGTCCC	AAGCCCCCAAAGGAA
ATTACTCGGGGGGCC	TGTGGACTGGTCCCT	AGCCCCCAAAGGAAT
TTACTCGGGGGGCCA	GTGGACTGGTCCCTG	GCCCCCAAAGGAATG
TACTCGGGGGGCCAT	TGGACTGGTCCCTGA	CCCCCAAAGGAATGT
ACTCGGGGGGCCATC	GGACTGGTCCCTGAT	CCCCAAAGGAATGTG
CTCGGGGGGCCATCA	GACTGGTCCCTGATC	CCCAAAGGAATGTGG
TCGGGGGGCCATCAG	ACTGGTCCCTGATCC	CCAAAGGAATGTGGG
CGGGCGGCCATCAGG	CTGGTCCCTGATCCT	CAAAGGAATGTGGGG
GGGGGGCCATCAGGA	TGGTCCCTGATCCTG	AAAGGAATGTGGGGA
GGGGGCCATCAGGAT	GGTCCCTGATCCTGG	AAGGAATGTGGGGAC
GGGGCCATCAGGATT	GTCCCTGATCCTGGA	AGGAATGTGGGGACC
GGGCCATCAGGATTG	TCCCTGATCCTGGAT	GGAATGTGGGGACCT
GGCCATCAGGATTGA	CCCTGATCCTGGATG	GAATGTGGGGACCTG
GCCATCAGGATTGAG	CCTGATCCTGGATGC	AATGTGGGGACCTGT
CCATCAGGATTGAGA	CTGATCCTGGATGCG	ATGTGGGGACCTGTG
CATCAGGATTGAGAA	TGATCCTGGATGCGG	TGTGGGGACCTGTGT
ATCAGGATTGAGAAA	GATCCTGGATGCGGT	GTGGGGACCTGTGTC
TCAGGATTGAGAAAA	ATCCTGGATGCGGTG	TGGGGACCTGTGTCC
CAGGATTGAGAAAAA	TCCTGGATGCGGTGT	GGGGACCTGTGTCCA
AGGATTGAGAAAAAT	CCTGGATGCGGTGTC	GGGACCTGTGTCCAG
GGATTGAGAAAAATG	CTGGATGCGGTGTCC	GGACCTGTGTCCAGG
GATTGAGAAAAATGC	TGGATGCGGTGTCCA	GACCTGTGTCCAGGG
ATTGAGAAAAATGCT	GGATGCGGTGTCCAA	ACCTGTGTCCAGGGA
TTGAGAAAAATGCTG	GATGCGGTGTCCAAT	CCTGTGTCCAGGGAC
CTGTGTCCAGGGACC	TGAGTACAACTACCG	CGTGTGGGAAGCGGG
TGTGTCCAGGGACCA	GAGTACAACTACCGC	GTGTGGGAAGCGGGC
GTGTCCAGGGACCAT	AGTACAACTACCGCT	TGTGGGAAGCGGGCG
TGTCCAGGGACCATG	GTACAACTACCGCTG	GTGGGAAGCGGGCGT
GTCCAGGGACCATGG	TACAACTACCGCTGC	TGGGAAGCGGGCGTG
TCCAGGGACCATGGA	ACAACTACCGCTGCT	GGGAAGCGGGCGTGC
CCAGGGACCATGGAG	CAACTACCGCTGCTG	GGAAGCGGGCGTGCA
CAGGGACCATGGAGG	AACTACCGCTGCTGG	GAAGCGGGCGTGCAC
AGGGACCATGGAGGA	ACTACCGCTGCTGGA	AAGCGGGCGTGCACC
GGGACCATGGAGGAG	CTACCGCTGCTGGAC	AGCGGGCGTGCACCG
GGACCATGGAGGAGA	TACCGCTGCTGGACC	GCGGGCGTGCACCGA
GACCATGGAGGAGAA	ACCGCTGCTGGACCA	CGGGCGTGCACCGAG
ACCATGGAGGAGAAG	CCGCTGCTGGACCAC	GGGCGTGCACCGAGA
CCATGGAGGAGAAGC	CGCTGCTGGACCACA	GGCGTGCACCGAGAA
CATGGAGGAGAAGCC	GCTGCTGGACCACAA	GCGTGCACCGAGAAC
ATGGAGGAGAAGCCG	CTGCTGGACCACAAA	CGTGCACCGAGAACA
TGGAGGAGAAGCCGA	TGCTGGACCACAAAC	GTGCACCGAGAACAA
GGAGGAGAAGCCGAT	GCTGGACCACAAACC	TGCACCGAGAACAAT
GAGGAGAAGCCGATG	CTGGACCACAAACCG	GCACCGAGAACAATG
AGGAGAAGCCGATGT	TGGACCACAAACCGC	CACCGAGAACAATGA
GGAGAAGCCGATGTG	GGACCACAAACCGCT	ACCGAGAACAATGAG
GAGAAGCCGATGTGT	GACCACAAACCGCTG	CCGAGAACAATGAGT
AGAAGCCGATGTGTG	ACCACAAACCGCTGC	CGAGAACAATGAGTG
GAAGCCGATGTGTGA	CCACAAACCGCTGCC	GAGAACAATGAGTGC
AAGCCGATGTGTGAG	CACAAACCGCTGCCA	AGAACAATGAGTGCT
AGCCGATGTGTGAGA	ACAAACCGCTGCCAG	GAACAATGAGTGCTG
GCCGATGTGTGAGAA	CAAACCGCTGCCAGA	AACAATGAGTGCTGC
CCGATGTGTGAGAAG	AAACCGCTGCCAGAA	ACAATGAGTGCTGCC
CGATGTGTGAGAAGA	AACCGCTGCCAGAAA	CAATGAGTGCTGCCA
GATGTGTGAGAAGAC	ACCGCTGCCAGAAAA	AATGAGTGCTGCCAC
ATGTGTGAGAAGACC	CCGCTGCCAGAAAAT	ATGAGTGCTGCCACC
TGTGTGAGAAGACCA	CGCTGCCAGAAAATG	TGAGTGCTGCCACCC
GTGTGAGAAGACCAC	GCTGCCAGAAAATGT	GAGTGCTGCCACCCC
TGTGAGAAGACCACC	CTGCCAGAAAATGTG	AGTGCTGCCACCCCG
GTGAGAAGACCACCA	TGCCAGAAAATGTGC	GTGCTGCCACCCCGA
TGAGAAGACCACCAT	GCCAGAAAATGTGCC	TGCTGCCACCCCGAG
GAGAAGACCACCATC	CCAGAAAATGTGCCC	GCTGCCACCCCGAGT
AGAAGACCACCATCA	CAGAAAATGTGCCCA	CTGCCACCCCGAGTG
GAAGACCACCATCAA	AGAAAATGTGCCCAA	TGCCACCCCGAGTGC
AAGACCACCATCAAC	GAAAATGTGCCCAAG	GCCACCCCGAGTGCC
AGACCACCATCAACA	AAAATGTGCCCAAGC	CCACCCCGAGTGCCT
GACCACCATCAACAA	AAATGTGCCCAAGCA	CACCCCGAGTGCCTG
ACCACCATCAACAAT	AATGTGCCCAAGCAC	ACCCCGAGTGCCTGG
CCACCATCAACAATG	ATGTGCCCAAGCACG	CCCCGAGTGCCTGGG
CACCATCAACAATGA	TGTGCCCAAGCACGT	CCCGAGTGCCTGGGC
ACCATCAACAATGAG	GTGCCCAAGCACGTG	CCGAGTGCCTGGGCA
CCATCAACAATGAGT	TGCCCAAGCACGTGT	CGAGTGCCTGGGCAG
CATCAACAATGAGTA	GCCCAAGCACGTGTG	GAGTGCCTGGGCAGC
ATCAACAATGAGTAC	CCCAAGCACGTGTGG	AGTGCCTGGGCAGCT
TCAACAATGAGTACA	CCAAGCACGTGTGGG	GTGCCTGGGCAGCTG
CAACAATGAGTACAA	CAAGCACGTGTGGGA	TGCCTGGGCAGCTGC
AACAATGAGTACAAC	AAGCACGTGTGGGAA	GCCTGGGCAGCTGCA
ACAATGAGTACAACT	AGCACGTGTGGGAAG	CCTGGGCAGCTGCAG
CAATGAGTACAACTA	GCACGTGTGGGAAGC	CTGGGCAGCTGCAGC
AATGAGTACAACTAC	CACGTGTGGGAAGCG	TGGGCAGCTGCAGCG
ATGAGTACAACTACC	ACGTGTGGGAAGCGG	GGGCAGCTGCAGCGC
GGCAGCTGCAGCGCG	CTATGCCGGTGTCTG	GGCGCTGTGTGGACC
GCAGCTGCAGCGCGC	TATGCCGGTGTCTGT	GCGCTGTGTGGACCG
CAGCTGCAGCGCGCC	ATGCCGGTGTCTGTG	CGCTGTGTGGACCGT
AGCTGCAGCGCGCCT	TGCCGGTGTCTGTGT	GCTGTGTGGACCGTG
GCTGCAGCGCGCCTG	GCCGGTGTCTGTGTG	CTGTGTGGACCGTGA
CTGCAGCGCGCCTGA	CCGGTGTCTGTGTGC	TGTGTGGACCGTGAC
TGCAGCGCGCCTGAC	CGGTGTCTGTGTGCC	GTGTGGACCGTGACT
GCAGCGCGCCTGACA	GGTGTCTGTGTGCCT	TGTGGACCGTGACTT
CAGCGCGCCTGACAA	GTGTCTGTGTGCCTG	GTGGACCGTGACTTC
AGCGCGCCTGACAAC	TGTCTGTGTGCCTGC	TGGACCGTGACTTCT
GCGCGCCTGACAACG	GTCTGTGTGCCTGCC	GGACCGTGACTTCTG
CGCGCCTGACAACGA	TCTGTGTGCCTGCCT	GACCGTGACTTCTGC
GCGCCTGACAACGAC	CTGTGTGCCTGCCTG	ACCGTGACTTCTGCG
CGCCTGACAACGACA	TGTGTGCCTGCCTGC	CCGTGACTTCTGCGC
GCCTGACAACGACAC	GTGTGCCTGCCTGCC	CGTGACTTCTGCGCC
CCTGACAACGACACG	TGTGCCTGCCTGCCC	GTGACTTCTGCGCCA
CTGACAACGACACGG	GTGCCTGCCTGCCCG	TGACTTCTGCGCCAA
TGACAACGACACGGC	TGCCTGCCTGCCCGC	GACTTCTGCGCCAAC
GACAACGACACGGCC	GCCTGCCTGCCCGCC	ACTTCTGCGCCAACA
ACAACGACACGGCCT	CCTGCCTGCCCGCCC	CTTCTGCGCCAACAT
CAACGACACGGCCTG	CTGCCTGCCCGCCCA	TTCTGCGCCAACATC
AACGACACGGCCTGT	TGCCTGCCCGCCCAA	TCTGCGCCAACATCC
ACGACACGGCCTGTG	GCCTGCCCGCCCAAC	CTGCGCCAACATCCT
CGACACGGCCTGTGT	CCTGCCCGCCCAACA	TGCGCCAACATCCTC
GACACGGCCTGTGTA	CTGCCCGCCCAACAC	GCGCCAACATCCTCA
ACACGGCCTGTGTAG	TGCCCGCCCAACACC	CGCCAACATCCTCAG
CACGGCCTGTGTAGC	GCCCGCCCAACACCT	GCCAACATCCTCAGC
ACGGCCTGTGTAGCT	CCCGCCCAACACCTA	CCAACATCCTCAGCG
CGGCCTGTGTAGCTT	CCGCCCAACACCTAC	CAACATCCTCAGCGC
GGCCTGTGTAGCTTG	CGCCCAACACCTACA	AACATCCTCAGCGCC
GCCTGTGTAGCTTGC	GCCCAACACCTACAG	ACATCCTCAGCGCCG
CCTGTGTAGCTTGCC	CCCAACACCTACAGG	CATCCTCAGCGCCGA
CTGTGTAGCTTGCCG	CCAACACCTACAGGT	ATCCTCAGCGCCGAG
TGTGTAGCTTGCCGC	CAACACCTACAGGTT	TCCTCAGCGCCGAGA
GTGTAGCTTGCCGCC	AACACCTACAGGTTT	CCTCAGCGCCGAGAG
TGTAGCTTGCCGCCA	ACACCTACAGGTTTG	CTCAGCGCCGAGAGC
GTAGCTTGCCGCCAC	CACCTACAGGTTTGA	TCAGCGCCGAGAGCA
TAGCTTGCCGCCACT	ACCTACAGGTTTGAG	CAGCGCCGAGAGCAG
AGCTTGCCGCCACTA	CCTACAGGTTTGAGG	AGCGCCGAGAGCAGC
GCTTGCCGCCACTAC	CTACAGGTTTGAGGG	GCGCCGAGAGCAGCG
CTTGCCGCCACTACT	TACAGGTTTGAGGGC	CGCCGAGAGCAGCGA
TTGCCGCCACTACTA	ACAGGTTTGAGGGCT	GCCGAGAGCAGCGAC
TGCCGCCACTACTAC	CAGGTTTGAGGGCTG	CCGAGAGCAGCGACT
GCCGCCACTACTACT	AGGTTTGAGGGCTGG	CGAGAGCAGCGACTC
CCGCCACTACTACTA	GGTTTGAGGGCTGGC	GAGAGCAGCGACTCC
CGCCACTACTACTAT	GTTTGAGGGCTGGCG	AGAGCAGCGACTCCG
GCCACTACTACTATG	TTTGAGGGCTGGCGC	GAGCAGCGACTCCGA
CCACTACTACTATGC	TTGAGGGCTGGCGCT	AGCAGCGACTCCGAG
CACTACTACTATGCC	TGAGGGCTGGCGCTG	GCAGCGACTCCGAGG
ACTACTACTATGCCG	GAGGGCTGGCGCTGT	CAGCGACTCCGAGGG
CTACTACTATGCCGG	AGGGCTGGCGCTGTG	AGCGACTCCGAGGGG
TACTACTATGCCGGT	GGGCTGGCGCTGTGT	GCGACTCCGAGGGGT
ACTACTATGCCGGTG	GGCTGGCGCTGTGTG	CGACTCCGAGGGGTT
CTACTATGCCGGTGT	GCTGGCGCTGTGTGG	GACTCCGAGGGGTTT
TACTATGCCGGTGTC	CTGGCGCTGTGTGGA	ACTCCGAGGGGTTTG
ACTATGCCGGTGTCT	TGGCGCTGTGTGGAC	CTCCGAGGGGTTTGT
TCCGAGGGGTTTGTG	CATCCGCAACGGCAG	AGGTCTGTGAGGAAG
CCGAGGGGTTTGTGA	ATCCGCAACGGCAGC	GGTCTGTGAGGAAGA
CGAGGGGTTTGTGAT	TCCGCAACGGCAGCC	GTCTGTGAGGAAGAA
GAGGGGTTTGTGATC	CCGCAACGGCAGCCA	TCTGTGAGGAAGAAA
AGGGGTTTGTGATCC	CGCAACGGCAGCCAG	CTGTGAGGAAGAAAA
GGGGTTTGTGATCCA	GCAACGGCAGCCAGA	TGTGAGGAAGAAAAG
GGGTTTGTGATCCAC	CAACGGCAGCCAGAG	GTGAGGAAGAAAAGA
GGTTTGTGATCCACG	AACGGCAGCCAGAGC	TGAGGAAGAAAAGAA
GTTTGTGATCCACGA	ACGGCAGCCAGAGCA	GAGGAAGAAAAGAAA
TTTGTGATCCACGAC	CGGCAGCCAGAGCAT	AGGAAGAAAAGAAAA
TTGTGATCCACGACG	GGCAGCCAGAGCATG	GGAAGAAAAGAAAAC
TGTGATCCACGACGG	GCAGCCAGAGCATGT	GAAGAAAAGAAAACA
GTGATCCACGACGGC	CAGCCAGAGCATGTA	AAGAAAAGAAAACAA
TGATCCACGACGGCG	AGCCAGAGCATGTAC	AGAAAAGAAAACAAA
GATCCACGACGGCGA	GCCAGAGCATGTACT	GAAAAGAAAACAAAG
ATCCACGACGGCGAG	CCAGAGCATGTACTG	AAAAGAAAACAAAGA
TCCACGACGGCGAGT	CAGAGCATGTACTGC	AAAGAAAACAAAGAC
CCACGACGGCGAGTG	AGAGCATGTACTGCA	AAGAAAACAAAGACC
CACGACGGCGAGTGC	GAGCATGTACTGCAT	AGAAAACAAAGACCA
ACGACGGCGAGTGCA	AGCATGTACTGCATC	GAAAACAAAGACCAT
CGACGGCGAGTGCAT	GCATGTACTGCATCC	AAAACAAAGACCATT
GACGGCGAGTGCATG	CATGTACTGCATCCC	AAACAAAGACCATTG
ACGGCGAGTGCATGC	ATGTACTGCATCCCT	AACAAAGACCATTGA
CGGCGAGTGCATGCA	TGTACTGCATCCCTT	ACAAAGACCATTGAT
GGCGAGTGCATGCAG	GTACTGCATCCCTTG	CAAAGACCATTGATT
GCGAGTGCATGCAGG	TACTGCATCCCTTGT	AAAGACCATTGATTC
CGAGTGCATGCAGGA	ACTGCATCCCTTGTG	AAGACCATTGATTCT
GAGTGCATGCAGGAG	CTGCATCCCTTGTGA	AGACCATTGATTCTG
AGTGCATGCAGGAGT	TGCATCCCTTGTGAA	GACCATTGATTCTGT
GTGCATGCAGGAGTG	GCATCCCTTGTGAAG	ACCATTGATTCTGTT
TGCATGCAGGAGTGC	CATCCCTTGTGAAGG	CCATTGATTCTGTTA
GCATGCAGGAGTGCC	ATCCCTTGTGAAGGT	CATTGATTCTGTTAC
CATGCAGGAGTGCCC	TCCCTTGTGAAGGTC	ATTGATTCTGTTACT
ATGCAGGAGTGCCCC	CCCTTGTGAAGGTCC	TTGATTCTGTTACTT
TGCAGGAGTGCCCCT	CCTTGTGAAGGTCCT	TGATTCTGTTACTTC
GCAGGAGTGCCCCTC	CTTGTGAAGGTCCTT	GATTCTGTTACTTCT
CAGGAGTGCCCCTCG	TTGTGAAGGTCCTTG	ATTCTGTTACTTCTG
AGGAGTGCCCCTCGG	TGTGAAGGTCCTTGC	TTCTGTTACTTCTGC
GGAGTGCCCCTCGGG	GTGAAGGTCCTTGCC	TCTGTTACTTCTGCT
GAGTGCCCCTCGGGC	TGAAGGTCCTTGCCC	CTGTTACTTCTGCTC
AGTGCCCCTCGGGCT	GAAGGTCCTTGCCCG	TGTTACTTCTGCTCA
GTGCCCCTCGGGCTT	AAGGTCCTTGCCCGA	GTTACTTCTGCTCAG
TGCCCCTCGGGCTTC	AGGTCCTTGCCCGAA	TTACTTCTGCTCAGA
GCCCCTCGGGCTTCA	GGTCCTTGCCCGAAG	TACTTCTGCTCAGAT
CCCCTCGGGCTTCAT	GTCCTTGCCCGAAGG	ACTTCTGCTCAGATG
CCCTCGGGCTTCATC	TCCTTGCCCGAAGGT	CTTCTGCTCAGATGC
CCTCGGGCTTCATCC	CCTTGCCCGAAGGTC	TTCTGCTCAGATGCT
CTCGGGCTTCATCCG	CTTGCCCGAAGGTCT	TCTGCTCAGATGCTC
TCGGGCTTCATCCGC	TTGCCCGAAGGTCTG	CTGCTCAGATGCTCC
CGGGCTTCATCCGCA	TGCCCGAAGGTCTGT	TGCTCAGATGCTCCA
GGGCTTCATCCGCAA	GCCCGAAGGTCTGTG	GCTCAGATGCTCCAA
GGCTTCATCCGCAAC	CCCGAAGGTCTGTGA	CTCAGATGCTCCAAG
GCTTCATCCGCAACG	CCGAAGGTCTGTGAG	TCAGATGCTCCAAGG
CTTCATCCGCAACGG	CGAAGGTCTGTGAGG	CAGATGCTCCAAGGA
TTCATCCGCAACGGC	GAAGGTCTGTGAGGA	AGATGCTCCAAGGAT
TCATCCGCAACGGCA	AAGGTCTGTGAGGAA	GATGCTCCAAGGATG
ATGCTCCAAGGATGC	GAATAACATTGCTTC	CCTACGTGAAGATCC
TGCTCCAAGGATGCA	AATAACATTGCTTCA	CTACGTGAAGATCCG
GCTCCAAGGATGCAC	ATAACATTGCTTCAG	TACGTGAAGATCCGC
CTCCAAGGATGCACC	TAACATTGCTTCAGA	ACGTGAAGATCCGCC
TCCAAGGATGCACCA	AACATTGCTTCAGAG	CGTGAAGATCCGCCA
CCAAGGATGCACCAT	ACATTGCTTCAGAGC	GTGAAGATCCGCCAT
CAAGGATGCACCATC	CATTGCTTCAGAGCT	TGAAGATCCGCCATT
AAGGATGCACCATCT	ATTGCTTCAGAGCTG	GAAGATCCGCCATTC
AGGATGCACCATCTT	TTGCTTCAGAGCTGG	AAGATCCGCCATTCT
GGATGCACCATCTTC	TGCTTCAGAGCTGGA	AGATCCGCCATTCTC
GATGCACCATCTTCA	GCTTCAGAGCTGGAG	GATCCGCCATTCTCA
ATGCACCATCTTCAA	CTTCAGAGCTGGAGA	ATCCGCCATTCTCAT
TGCACCATCTTCAAG	TTCAGAGCTGGAGAA	TCCGCCATTCTCATG
GCACCATCTTCAAGG	TCAGAGCTGGAGAAC	CCGCCATTCTCATGC
CACCATCTTCAAGGG	CAGAGCTGGAGAACT	CGCCATTCTCATGCC
ACCATCTTCAAGGGC	AGAGCTGGAGAACTT	GCCATTCTCATGCCT
CCATCTTCAAGGGCA	GAGCTGGAGAACTTC	CCATTCTCATGCCTT
CATCTTCAAGGGCAA	AGCTGGAGAACTTCA	CATTCTCATGCCTTG
ATCTTCAAGGGCAAT	GCTGGAGAACTTCAT	ATTCTCATGCCTTGG
TCTTCAAGGGCAATT	CTGGAGAACTTCATG	TTCTCATGCCTTGGT
CTTCAAGGGCAATTT	TGGAGAACTTCATGG	TCTCATGCCTTGGTC
TTCAAGGGCAATTTG	GGAGAACTTCATGGG	CTCATGCCTTGGTCT
TCAAGGGCAATTTGC	GAGAACTTCATGGGG	TCATGCCTTGGTCTC
CAAGGGCAATTTGCT	AGAACTTCATGGGGC	CATGCCTTGGTCTCC
AAGGGCAATTTGCTC	GAACTTCATGGGGCT	ATGCCTTGGTCTCCT
AGGGCAATTTGCTCA	AACTTCATGGGGCTC	TGCCTTGGTCTCCTT
GGGCAATTTGCTCAT	ACTTCATGGGGCTCA	GCCTTGGTCTCCTTG
GGCAATTTGCTCATT	CTTCATGGGGCTCAT	CCTTGGTCTCCTTGT
GCAATTTGCTCATTA	TTCATGGGGCTCATC	CTTGGTCTCCTTGTC
CAATTTGCTCATTAA	TCATGGGGCTCATCG	TTGGTCTCCTTGTCC
AATTTGCTCATTAAC	CATGGGGCTCATCGA	TGGTCTCCTTGTCCT
ATTTGCTCATTAACA	ATGGGGCTCATCGAG	GGTCTCCTTGTCCTT
TTTGCTCATTAACAT	TGGGGCTCATCGAGG	GTCTCCTTGTCCTTC
TTGCTCATTAACATC	GGGGCTCATCGAGGT	TCTCCTTGTCCTTCC
TGCTCATTAACATCC	GGGCTCATCGAGGTG	CTCCTTGTCCTTCCT
GCTCATTAACATCCG	GGCTCATCGAGGTGG	TCCTTGTCCTTCCTA
CTCATTAACATCCGA	GCTCATCGAGGTGGT	CCTTGTCCTTCCTAA
TCATTAACATCCGAC	CTCATCGAGGTGGTG	CTTGTCCTTCCTAAA
CATTAACATCCGACG	TCATCGAGGTGGTGA	TTGTCCTTCCTAAAA
ATTAACATCCGACGG	CATCGAGGTGGTGAC	TGTCCTTCCTAAAAA
TTAACATCCGACGGG	ATCGAGGTGGTGACG	GTCCTTCCTAAAAAA
TAACATCCGACGGGG	TCGAGGTGGTGACGG	TCCTTCCTAAAAAAC
AACATCCGACGGGGG	CGAGGTGGTGACGGG	CCTTCCTAAAAAACC
ACATCCGACGGGGGA	GAGGTGGTGACGGGC	CTTCCTAAAAAACCT
CATCCGACGGGGGAA	AGGTGGTGACGGGCT	TTCCTAAAAAACCTT
ATCCGACGGGGGAAT	GGTGGTGACGGGCTA	TCCTAAAAAACCTTC
TCCGACGGGGGAATA	GTGGTGACGGGCTAC	CCTAAAAAACCTTCG
CCGACGGGGGAATAA	TGGTGACGGGCTACG	CTAAAAAACCTTCGC
CGACGGGGGAATAAC	GGTGACGGGCTACGT	TAAAAAACCTTCGCC
GACGGGGGAATAACA	GTGACGGGCTACGTG	AAAAAACCTTCGCCT
ACGGGGGAATAACAT	TGACGGGCTACGTGA	AAAAACCTTCGCCTC
CGGGGGAATAACATT	GACGGGCTACGTGAA	AAAACCTTCGCCTCA
GGGGGAATAACATTG	ACGGGCTACGTGAAG	AAACCTTCGCCTCAT
GGGGAATAACATTGC	CGGGCTACGTGAAGA	AACCTTCGCCTCATC
GGGAATAACATTGCT	GGGCTACGTGAAGAT	ACCTTCGCCTCATCC
GGAATAACATTGCTT	GGCTACGTGAAGATC	CCTTCGCCTCATCCT
CTTCGCCTCATCCTA	CGACAACCAGAACTT	AAGCAGGGAAAATGT
TTCGCCTCATCCTAG	GACAACCAGAACTTG	AGCAGGGAAAATGTA
TCGCCTCATCCTAGG	ACAACCAGAACTTGC	GCAGGGAAAATGTAC
CGCCTCATCCTAGGA	CAACCAGAACTTGCA	CAGGGAAAATGTACT
GCCTCATCCTAGGAG	AACCAGAACTTGCAG	AGGGAAAATGTACTT
CCTCATCCTAGGAGA	ACCAGAACTTGCAGC	GGGAAAATGTACTTT
CTCATCCTAGGAGAG	CCAGAACTTGCAGCA	GGAAAATGTACTTTG
TCATCCTAGGAGAGG	CAGAACTTGCAGCAA	GAAAATGTACTTTGC
CATCCTAGGAGAGGA	AGAACTTGCAGCAAC	AAAATGTACTTTGCT
ATCCTAGGAGAGGAG	GAACTTGCAGCAACT	AAATGTACTTTGCTT
TCCTAGGAGAGGAGC	AACTTGCAGCAACTG	AATGTACTTTGCTTT
CCTAGGAGAGGAGCA	ACTTGCAGCAACTGT	ATGTACTTTGCTTTC
CTAGGAGAGGAGCAG	CTTGCAGCAACTGTG	TGTACTTTGCTTTCA
TAGGAGAGGAGCAGC	TTGCAGCAACTGTGG	GTACTTTGCTTTCAA
AGGAGAGGAGCAGCT	TGCAGCAACTGTGGG	TACTTTGCTTTCAAT
GGAGAGGAGCAGCTA	GCAGCAACTGTGGGA	ACTTTGCTTTCAATC
GAGAGGAGCAGCTAG	CAGCAACTGTGGGAC	CTTTGCTTTCAATCC
AGAGGAGCAGCTAGA	AGCAACTGTGGGACT	TTTGCTTTCAATCCC
GAGGAGCAGCTAGAA	GCAACTGTGGGACTG	TTGCTTTCAATCCCA
AGGAGCAGCTAGAAG	CAACTGTGGGACTGG	TGCTTTCAATCCCAA
GGAGCAGCTAGAAGG	AACTGTGGGACTGGG	GCTTTCAATCCCAAA
GAGCAGCTAGAAGGG	ACTGTGGGACTGGGA	CTTTCAATCCCAAAT
AGCAGCTAGAAGGGA	CTGTGGGACTGGGAC	TTTCAATCCCAAATT
GCAGCTAGAAGGGAA	TGTGGGACTGGGACC	TTCAATCCCAAATTA
CAGCTAGAAGGGAAT	GTGGGACTGGGACCA	TCAATCCCAAATTAT
AGCTAGAAGGGAATT	TGGGACTGGGACCAC	CAATCCCAAATTATG
GCTAGAAGGGAATTA	GGGACTGGGACCACC	AATCCCAAATTATGT
CTAGAAGGGAATTAC	GGACTGGGACCACCG	ATCCCAAATTATGTG
TAGAAGGGAATTACT	GACTGGGACCACCGC	TCCCAAATTATGTGT
AGAAGGGAATTACTC	ACTGGGACCACCGCA	CCCAAATTATGTGTT
GAAGGGAATTACTCC	CTGGGACCACCGCAA	CCAAATTATGTGTTT
AAGGGAATTACTCCT	TGGGACCACCGCAAC	CAAATTATGTGTTTC
AGGGAATTACTCCTT	GGGACCACCGCAACC	AAATTATGTGTTTCC
GGGAATTACTCCTTC	GGACCACCGCAACCT	AATTATGTGTTTCCG
GGAATTACTCCTTCT	GACCACCGCAACCTG	ATTATGTGTTTCCGA
GAATTACTCCTTCTA	ACCACCGCAACCTGA	TTATGTGTTTCCGAA
AATTACTCCTTCTAC	CCACCGCAACCTGAC	TATGTGTTTCCGAAA
ATTACTCCTTCTACG	CACCGCAACCTGACC	ATGTGTTTCCGAAAT
TTACTCCTTCTACGT	ACCGCAACCTGACCA	TGTGTTTCCGAAATT
TACTCCTTCTACGTC	CCGCAACCTGACCAT	GTGTTTCCGAAATTT
ACTCCTTCTACGTCC	CGCAACCTGACCATC	TGTTTCCGAAATTTA
CTCCTTCTACGTCCT	GCAACCTGACCATCA	GTTTCCGAAATTTAC
TCCTTCTACGTCCTC	CAACCTGACCATCAA	TTTCCGAAATTTACC
CCTTCTACGTCCTCG	AACCTGACCATCAAA	TTCCGAAATTTACCG
CTTCTACGTCCTCGA	ACCTGACCATCAAAG	TCCGAAATTTACCGC
TTCTACGTCCTCGAC	CCTGACCATCAAAGC	CCGAAATTTACCGCA
TCTACGTCCTCGACA	CTGACCATCAAAGCA	CGAAATTTACCGCAT
CTACGTCCTCGACAA	TGACCATCAAAGCAG	GAAATTTACCGCATG
TACGTCCTCGACAAC	GACCATCAAAGCAGG	AAATTTACCGCATGG
ACGTCCTCGACAACC	ACCATCAAAGCAGGG	AATTTACCGCATGGA
CGTCCTCGACAACCA	CCATCAAAGCAGGGA	ATTTACCGCATGGAG
GTCCTCGACAACCAG	CATCAAAGCAGGGAA	TTTACCGCATGGAGG
TCCTCGACAACCAGA	ATCAAAGCAGGGAAA	TTACCGCATGGAGGA
CCTCGACAACCAGAA	TCAAAGCAGGGAAAA	TACCGCATGGAGGAA
CTCGACAACCAGAAC	CAAAGCAGGGAAAAT	ACCGCATGGAGGAAG
TCGACAACCAGAACT	AAAGCAGGGAAAATG	CCGCATGGAGGAAGT
CGCATGGAGGAAGTG	CAGGAACAACGGGGA	CCACCACGTCGAAGA
GCATGGAGGAAGTGA	AGGAACAACGGGGAG	CACCACGTCGAAGAA
CATGGAGGAAGTGAC	GGAACAACGGGGAGA	ACCACGTCGAAGAAT
ATGGAGGAAGTGACG	GAACAACGGGGAGAG	CCACGTCGAAGAATC
TGGAGGAAGTGACGG	AACAACGGGGAGAGA	CACGTCGAAGAATCG
GGAGGAAGTGACGGG	ACAACGGGGAGAGAG	ACGTCGAAGAATCGC
GAGGAAGTGACGGGG	CAACGGGGAGAGAGC	CGTCGAAGAATCGCA
AGGAAGTGACGGGGA	AACGGGGAGAGAGCC	GTCGAAGAATCGCAT
GGAAGTGACGGGGAC	ACGGGGAGAGAGCCT	TCGAAGAATCGCATC
GAAGTGACGGGGACT	CGGGGAGAGAGCCTC	CGAAGAATCGCATCA
AAGTGACGGGGACTA	GGGGAGAGAGCCTCC	GAAGAATCGCATCAT
AGTGACGGGGACTAA	GGGAGAGAGCCTCCT	AAGAATCGCATCATC
GTGACGGGGACTAAA	GGAGAGAGCCTCCTG	AGAATCGCATCATCA
TGACGGGGACTAAAG	GAGAGAGCCTCCTGT	GAATCGCATCATCAT
GACGGGGACTAAAGG	AGAGAGCCTCCTGTG	AATCGCATCATCATA
ACGGGGACTAAAGGG	GAGAGCCTCCTGTGA	ATCGCATCATCATAA
CGGGGACTAAAGGGC	AGAGCCTCCTGTGAA	TCGCATCATCATAAC
GGGGACTAAAGGGCG	GAGCCTCCTGTGAAA	CGCATCATCATAACC
GGGACTAAAGGGCGC	AGCCTCCTGTGAAAG	GCATCATCATAACCT
GGACTAAAGGGCGCC	GCCTCCTGTGAAAGT	CATCATCATAACCTG
GACTAAAGGGCGCCA	CCTCCTGTGAAAGTG	ATCATCATAACCTGG
ACTAAAGGGCGCCAA	CTCCTGTGAAAGTGA	TCATCATAACCTGGC
CTAAAGGGCGCCAAA	TCCTGTGAAAGTGAC	CATCATAACCTGGCA
TAAAGGGCGCCAAAG	CCTGTGAAAGTGACG	ATCATAACCTGGCAC
AAAGGGCGCCAAAGC	CTGTGAAAGTGACGT	TCATAACCTGGCACC
AAGGGCGCCAAAGCA	TGTGAAAGTGACGTC	CATAACCTGGCACCG
AGGGCGCCAAAGCAA	GTGAAAGTGACGTCC	ATAACCTGGCACCGG
GGGCGCCAAAGCAAA	TGAAAGTGACGTCCT	TAACCTGGCACCGGT
GGCGCCAAAGCAAAG	GAAAGTGACGTCCTG	AACCTGGCACCGGTA
GCGCCAAAGCAAAGG	AAAGTGACGTCCTGC	ACCTGGCACCGGTAC
CGCCAAAGCAAAGGG	AAGTGACGTCCTGCA	CCTGGCACCGGTACC
GCCAAAGCAAAGGGG	AGTGACGTCCTGCAT	CTGGCACCGGTACCG
CCAAAGCAAAGGGGA	GTGACGTCCTGCATT	TGGCACCGGTACCGG
CAAAGCAAAGGGGAC	TGACGTCCTGCATTT	GGCACCGGTACCGGC
AAAGCAAAGGGGACA	GACGTCCTGCATTTC	GCACCGGTACCGGCC
AAGCAAAGGGGACAT	ACGTCCTGCATTTCA	CACCGGTACCGGCCC
AGCAAAGGGGACATA	CGTCCTGCATTTCAC	ACCGGTACCGGCCCC
GCAAAGGGGACATAA	GTCCTGCATTTCACC	CCGGTACCGGCCCCC
CAAAGGGGACATAAA	TCCTGCATTTCACCT	CGGTACCGGCCCCCT
AAAGGGGACATAAAC	CCTGCATTTCACCTC	GGTACCGGCCCCCTG
AAGGGGACATAAACA	CTGCATTTCACCTCC	GTACCGGCCCCCTGA
AGGGGACATAAACAC	TGCATTTCACCTCCA	TACCGGCCCCCTGAC
GGGGACATAAACACC	GCATTTCACCTCCAC	ACCGGCCCCCTGACT
GGGACATAAACACCA	CATTTCACCTCCACC	CCGGCCCCCTGACTA
GGACATAAACACCAG	ATTTCACCTCCACCA	CGGCCCCCTGACTAC
GACATAAACACCAGG	TTTCACCTCCACCAC	GGCCCCCTGACTACA
ACATAAACACCAGGA	TTCACCTCCACCACC	GCCCCCTGACTACAG
CATAAACACCAGGAA	TCACCTCCACCACCA	CCCCCTGACTACAGG
ATAAACACCAGGAAC	CACCTCCACCACCAC	CCCCTGACTACAGGG
TAAACACCAGGAACA	ACCTCCACCACCACG	CCCTGACTACAGGGA
AAACACCAGGAACAA	CCTCCACCACCACGT	CCTGACTACAGGGAT
AACACCAGGAACAAC	CTCCACCACCACGTC	CTGACTACAGGGATC
ACACCAGGAACAACG	TCCACCACCACGTCG	TGACTACAGGGATCT
CACCAGGAACAACGG	CCACCACCACGTCGA	GACTACAGGGATCTC
ACCAGGAACAACGGG	CACCACCACGTCGAA	ACTACAGGGATCTCA
CCAGGAACAACGGGG	ACCACCACGTCGAAG	CTACAGGGATCTCAT
TACAGGGATCTCATC	CACAGAGTATGATGG	TGGACCTCCCGCCCA
ACAGGGATCTCATCA	ACAGAGTATGATGGG	GGACCTCCCGCCCAA
CAGGGATCTCATCAG	CAGAGTATGATGGGC	GACCTCCCGCCCAAC
AGGGATCTCATCAGC	AGAGTATGATGGGCA	ACCTCCCGCCCAACA
GGGATCTCATCAGCT	GAGTATGATGGGCAG	CCTCCCGCCCAACAA
GGATCTCATCAGCTT	AGTATGATGGGCAGG	CTCCCGCCCAACAAG
GATCTCATCAGCTTC	GTATGATGGGCAGGA	TCCCGCCCAACAAGG
ATCTCATCAGCTTCA	TATGATGGGCAGGAT	CCCGCCCAACAAGGA
TCTCATCAGCTTCAC	ATGATGGGCAGGATG	CCGCCCAACAAGGAC
CTCATCAGCTTCACC	TGATGGGCAGGATGC	CGCCCAACAAGGACG
TCATCAGCTTCACCG	GATGGGCAGGATGCC	GCCCAACAAGGACGT
CATCAGCTTCACCGT	ATGGGCAGGATGCCT	CCCAACAAGGACGTG
ATCAGCTTCACCGTT	TGGGCAGGATGCCTG	CCAACAAGGACGTGG
TCAGCTTCACCGTTT	GGGCAGGATGCCTGC	CAACAAGGACGTGGA
CAGCTTCACCGTTTA	GGCAGGATGCCTGCG	AACAAGGACGTGGAG
AGCTTCACCGTTTAC	GCAGGATGCCTGCGG	ACAAGGACGTGGAGC
GCTTCACCGTTTACT	CAGGATGCCTGCGGC	CAAGGACGTGGAGCC
CTTCACCGTTTACTA	AGGATGCCTGCGGCT	AAGGACGTGGAGCCC
TTCACCGTTTACTAC	GGATGCCTGCGGCTC	AGGACGTGGAGCCCG
TCACCGTTTACTACA	GATGCCTGCGGCTCC	GGACGTGGAGCCCGG
CACCGTTTACTACAA	ATGCCTGCGGCTCCA	GACGTGGAGCCCGGC
ACCGTTTACTACAAG	TGCCTGCGGCTCCAA	ACGTGGAGCCCGGCA
CCGTTTACTACAAGG	GCCTGCGGCTCCAAC	CGTGGAGCCCGGCAT
CGTTTACTACAAGGA	CCTGCGGCTCCAACA	GTGGAGCCCGGCATC
GTTTACTACAAGGAA	CTGCGGCTCCAACAG	TGGAGCCCGGCATCT
TTTACTACAAGGAAG	TGCGGCTCCAACAGC	GGAGCCCGGCATCTT
TTACTACAAGGAAGC	GCGGCTCCAACAGCT	GAGCCCGGCATCTTA
TACTACAAGGAAGCA	CGGCTCCAACAGCTG	AGCCCGGCATCTTAC
ACTACAAGGAAGCAC	GGCTCCAACAGCTGG	GCCCGGCATCTTACT
CTACAAGGAAGCACC	GCTCCAACAGCTGGA	CCCGGCATCTTACTA
TACAAGGAAGCACCC	CTCCAACAGCTGGAA	CCGGCATCTTACTAC
ACTAGGAAGCACCCT	TCCAACAGCTGGAAC	CGGCATCTTACTACA
CAAGGAAGCACCCTT	CCAACAGCTGGAACA	GGCATCTTACTACAT
AAGGAAGCACCCTTT	CAACAGCTGGAACAT	GCATCTTACTACATG
AGGAAGCACCCTTTA	AACAGCTGGAACATG	CATCTTACTACATGG
GGAAGCACCCTTTAA	ACAGCTGGAACATGG	ATCTTACTACATGGG
GAAGCACCCTTTAAG	CAGCTGGAACATGGT	TCTTACTACATGGGC
AAGCACCCTTTAAGA	AGCTGGAACATGGTG	CTTACTACATGGGCT
AGCACCCTTTAAGAA	GCTGGAACATGGTGG	TTACTACATGGGCTG
GCACCCTTTAAGAAT	CTGGAACATGGTGGA	TACTACATGGGCTGA
CACCCTTTAAGAATG	TGGAACATGGTGGAC	ACTACATGGGCTGAA
ACCCTTTAAGAATGT	GGAACATGGTGGACG	CTACATGGGCTGAAG
CCCTTTAAGAATGTC	GAACATGGTGGACGT	TACATGGGCTGAAGC
CCTTTAAGAATGTCA	AACATGGTGGACGTG	ACATGGGCTGAAGCC
CTTTAAGAATGTCAC	ACATGGTGGACGTGG	CATGGGCTGAAGCCC
TTTAAGAATGTCACA	CATGGTGGACGTGGA	ATGGGCTGAAGCCCT
TTAAGAATGTCACAG	ATGGTGGACGTGGAC	TGGGCTGAAGCCCTG
TAAGAATGTCACAGA	TGGTGGACGTGGACC	GGGCTGAAGCCCTGG
AAGAATGTCACAGAG	GGTGGACGTGGACCT	GGCTGAAGCCCTGGA
AGAATGTCACAGAGT	GTGGACGTGGACCTC	GCTGAAGCCCTGGAC
GAATGTCACAGAGTA	TGGACGTGGACCTCC	CTGAAGCCCTGGACT
AATGTCACAGAGTAT	GGACGTGGACCTCCC	TGAAGCCCTGGACTC
ATGTCACAGAGTATG	GACGTGGACCTCCCG	GAAGCCCTGGACTCA
TGTCACAGAGTATGA	ACGTGGACCTCCCGC	AAGCCCTGGACTCAG
GTCACAGAGTATGAT	CGTGGACCTCCCGCC	AGCCCTGGACTCAGT
TCACAGAGTATGATG	GTGGACCTCCCGCCC	GCCCTGGACTCAGTA
CCCTGGACTCAGTAC	CGACCATATCCGTGG	TTCCTTCCATTCCCT
CCTGGACTCAGTACG	GACCATATCCGTGGG	TCCTTCCATTCCCTT
CTGGACTCAGTACGC	ACCATATCCGTGGGG	CCTTCCATTCCCTTG
TGGACTCAGTACGCC	CCATATCCGTGGGGC	CTTCCATTCCCTTGG
GGACTCAGTACGCCG	CATATCCGTGGGGCC	TTCCATTCCCTTGGA
GACTCAGTACGCCGT	ATATCCGTGGGGCCA	TCCATTCCCTTGGAC
ACTCAGTACGCCGTT	TATCCGTGGGGCCAA	CCATTCCCTTGGACG
CTCAGTACGCCGTTT	ATCCGTGGGGCCAAG	CATTCCCTTGGACGT
TCAGTACGCCGTTTA	TCCGTGGGGCCAAGA	ATTCCCTTGGACGTT
CAGTACGCCGTTTAC	CCGTGGGGCCAAGAG	TTCCCTTGGACGTTC
AGTACGCCGTTTACG	CGTGGGGCCAAGAGT	TCCCTTGGACGTTCT
GTACGCCGTTTACGT	GTGGGGCCAAGAGTG	CCCTTGGACGTTCTT
TACGCCGTTTACGTC	TGGGGCCAAGAGTGA	CCTTGGACGTTCTTT
ACGCCGTTTACGTCA	GGGGCCAAGAGTGAG	CTTGGACGTTCTTTC
CGCCGTTTACGTCAA	GGGCCAAGAGTGAGA	TTGGACGTTCTTTCA
GCCGTTTACGTCAAG	GGCCAAGAGTGAGAT	TGGACGTTCTTTCAG
CCGTTTACGTCAAGG	GCCAAGAGTGAGATC	GGACGTTCTTTCAGC
CGTTTACGTCAAGGC	CCAAGAGTGAGATCT	GACGTTCTTTCAGCA
GTTTACGTCAAGGCT	CAAGAGTGAGATCTT	ACGTTCTTTCAGCAT
TTTACGTCAAGGCTG	AAGAGTGAGATCTTG	CGTTCTTTCAGCATC
TTACGTCAAGGCTGT	AGAGTGAGATCTTGT	GTTCTTTCAGCATCG
TACGTCAAGGCTGTG	GAGTGAGATCTTGTA	TTCTTTCAGCATCGA
ACGTCAAGGCTGTGA	AGTGAGATCTTGTAC	TCTTTCAGCATCGAA
CGTCAAGGCTGTGAC	GTGAGATCTTGTACA	CTTTCAGCATCGAAC
GTCAAGGCTGTGACC	TGAGATCTTGTACAT	TTTCAGCATCGAACT
TCAAGGCTGTGACCC	GAGATCTTGTACATT	TTCAGCATCGAACTC
CAAGGCTGTGACCCT	AGATCTTGTACATTC	TCAGCATCGAACTCC
AAGGCTGTGACCCTC	GATCTTGTACATTCG	CAGCATCGAACTCCT
AGGCTGTGACCCTCA	ATCTTGTACATTCGC	AGCATCGAACTCCTC
GGCTGTGACCCTCAC	TCTTGTACATTCGCA	GCATCGAACTCCTCT
GCTGTGACCCTCACC	CTTGTACATTCGCAC	CATCGAACTCCTCTT
CTGTGACCCTCACCA	TTGTACATTCGCACC	ATCGAACTCCTCTTC
TGTGACCCTCACCAT	TGTACATTCGCACCA	TCGAACTCCTCTTCT
GTGACCCTCACCATG	GTACATTCGCACCAA	CGAACTCCTCTTCTC
TGACCCTCACCATGG	TACATTCGCACCAAT	GAACTCCTCTTCTCA
GACCCTCACCATGGT	ACATTCGCACCAATG	AACTCCTCTTCTCAG
ACCCTCACCATGGTG	CATTCGCACCAATGC	ACTCCTCTTCTCAGT
CCCTCACCATGGTGG	ATTCGCACCAATGCT	CTCCTCTTCTCAGTT
CCTCACCATGGTGGA	TTCGCACCAATGCTT	TCCTCTTCTCAGTTA
CTCACCATGGTGGAG	TCGCACCAATGCTTC	CCTCTTCTCAGTTAA
TCACCATGGTGGAGA	CGCACCAATGCTTCA	CTCTTCTCAGTTAAT
CACCATGGTGGAGAA	GCACCAATGCTTCAG	TCTTCTCAGTTAATC
ACCATGGTGGAGAAC	CACCAATGCTTCAGT	CTTCTCAGTTAATCG
CCATGGTGGAGAACG	ACCAATGCTTCAGTT	TTCTCAGTTAATCGT
CATGGTGGAGAACGA	CCAATGCTTCAGTTC	TCTCAGTTAATCGTG
ATGGTGGAGAACGAC	CAATGCTTCAGTTCC	CTCAGTTAATCGTGA
TGGTGGAGAACGACC	AATGCTTCAGTTCCT	TCAGTTAATCGTGAA
GGTGGAGAACGACCA	ATGCTTCAGTTCCTT	CAGTTAATCGTGAAG
GTGGAGAACGACCAT	TGCTTCAGTTCCTTC	AGTTAATCGTGAAGT
TGGAGAACGACCATA	GCTTCAGTTCCTTCC	GTTAATCGTGAAGTG
GGAGAACGACCATAT	CTTCAGTTCCTTCCA	TTAATCGTGAAGTGG
GAGAACGACCATATC	TTCAGTTCCTTCCAT	TAATCGTGAAGTGGA
AGAACGACCATATCC	TCAGTTCCTTCCATT	AATCGTGAAGTGGAA
GAACGACCATATCCG	CAGTTCCTTCCATTC	ATCGTGAAGTGGAAC
AACGACCATATCCGT	AGTTCCTTCCATTCC	TCGTGAAGTGGAACC
ACGACCATATCCGTG	GTTCCTTCCATTCCC	CGTGAAGTGGAACCC
GTGAAGTGGAACCCT	CTGGCAGCGGCAGCC	ACAAAATCCCCATCA
TGAAGTGGAACCCTC	TGGCAGCGGCAGCCT	CAAAATCCCCATCAG
GAAGTGGAACCCTCC	GGCAGCGGCAGCCTC	AAAATCCCCATCAGG
AAGTGGAACCCTCCC	GCAGCGGCAGCCTCA	AAATCCCCATCAGGA
AGTGGAACCCTCCCT	CAGCGGCAGCCTCAG	AATCCCCATCAGGAA
GTGGAACCCTCCCTC	AGCGGCAGCCTCAGG	ATCCCCATCAGGAAG
TGGAACCCTCCCTCT	GCGGCAGCCTCAGGA	TCCCCATCAGGAAGT
GGAACCCTCCCTCTC	CGGCAGCCTCAGGAC	CCCCATCAGGAAGTA
GAACCCTCCCTCTCT	GGCAGCCTCAGGACG	CCCATCAGGAAGTAT
AACCCTCCCTCTCTG	GCAGCCTCAGGACGG	CCATCAGGAAGTATG
ACCCTCCCTCTCTGC	CAGCCTCAGGACGGC	CATCAGGAAGTATGC
CCCTCCCTCTCTGCC	AGCCTCAGGACGGCT	ATCAGGAAGTATGCC
CCTCCCTCTCTGCCC	GCCTCAGGACGGCTA	TCAGGAAGTATGCCG
CTCCCTCTCTGCCCA	CCTCAGGACGGCTAC	CAGGAAGTATGCCGA
TCCCTCTCTGCCCAA	CTCAGGACGGCTACC	AGGAAGTATGCCGAC
CCCTCTCTGCCCAAC	TCAGGACGGCTACCT	GGAAGTATGCCGACG
CCTCTCTGCCCAACG	CAGGACGGCTACCTT	GAAGTATGCCGACGG
CTCTCTGCCCAACGG	AGGACGGCTACCTTT	AAGTATGCCGACGGC
TCTCTGCCCAACGGC	GGACGGCTACCTTTA	AGTATGCCGACGGCA
CTCTGCCCAACGGCA	GACGGCTACCTTTAC	GTATGCCGACGGCAC
TCTGCCCAACGGCAA	ACGGCTACCTTTACC	TATGCCGACGGCACC
CTGCCCAACGGCAAC	CGGCTACCTTTACCG	ATGCCGACGGCACCA
TGCCCAACGGCAACC	GGCTACCTTTACCGG	TGCCGACGGCACCAT
GCCCAACGGCAACCT	GCTACCTTTACCGGC	GCCGACGGCACCATC
CCCAACGGCAACCTG	CTACCTTTACCGGCA	CCGACGGCACCATCG
CCAACGGCAACCTGA	TACCTTTACCGGCAC	CGACGGCACCATCGA
CAACGGCAACCTGAG	ACCTTTACCGGCACA	GACGGCACCATCGAC
AACGGCAACCTGAGT	CCTTTACCGGCACAA	ACGGCACCATCGACA
ACGGCAACCTGAGTT	CTTTACCGGCACAAT	CGGCACCATCGACAT
CGGCAACCTGAGTTA	TTTACCGGCACAATT	GGCACCATCGACATT
GGCAACCTGAGTTAC	TTACCGGCACAATTA	GCACCATCGACATTG
GCAACCTGAGTTACT	TACCGGCACAATTAC	CACCATCGACATTGA
CAACCTGAGTTACTA	ACCGGCACAATTACT	ACCATCGACATTGAG
AACCTGAGTTACTAC	CCGGCACAATTACTG	CCATCGACATTGAGG
ACCTGAGTTACTACA	CGGCACAATTACTGC	CATCGACATTGAGGA
CCTGAGTTACTACAT	GGCACAATTACTGCT	ATCGACATTGAGGAG
CTGAGTTACTACATT	GCACAATTACTGCTC	TCGACATTGAGGAGG
TGAGTTACTACATTG	CACAATTACTGCTCC	CGACATTGAGGAGGT
GAGTTACTACATTGT	ACAATTACTGCTCCA	GACATTGAGGAGGTC
AGTTACTACATTGTG	CAATTACTGCTCCAA	ACATTGAGGAGGTCA
GTTACTACATTGTGC	AATTACTGCTCCAAA	CATTGAGGAGGTCAC
TTACTACATTGTGCG	ATTACTGCTCCAAAG	ATTGAGGAGGTCACA
TACTACATTGTGCGC	TTACTGCTCCAAAGA	TTGAGGAGGTCACAG
ACTACATTGTGCGCT	TACTGCTCCAAAGAC	TGAGGAGGTCACAGA
CTACATTGTGCGCTG	ACTGCTCCAAAGACA	GAGGAGGTCACAGAG
TACATTGTGCGCTGG	CTGCTCCAAAGACAA	AGGAGGTCACAGAGA
ACATTGTGCGCTGGC	TGCTCCAAAGACAAA	GGAGGTCACAGAGAA
CATTGTGCGCTGGCA	GCTCCAAAGACAAAA	GAGGTCACAGAGAAC
ATTGTGCGCTGGCAG	CTCCAAAGACAAAAT	AGGTCACAGAGAACC
TTGTGCGCTGGCAGC	TCCAAAGACAAAATC	GGTCACAGAGAACCC
TGTGCGCTGGCAGCG	CCAAAGACAAAATCC	GTCACAGAGAACCCC
GTGCGCTGGCAGCGG	CAAAGACAAAATCCC	TCACAGAGAACCCCA
TGCGCTGGCAGCGGC	AAAGACAAAATCCCC	CACAGAGAACCCCAA
GCGCTGGCAGCGGCA	AAGACAAAATCCCCA	ACAGAGAACCCCAAG
CGCTGGCAGCGGCAG	AGACAAAATCCCCAT	CAGAGAACCCCAAGA
GCTGGCAGCGGCAGC	GACAAAATCCCCATC	AGAGAACCCCAAGAC
GAGAACCCCAAGACT	CAAAACTGAAGCCGA	TTGAGAATTTCCTGC
AGAACCCCAAGACTG	AAAACTGAAGCCGAG	TGAGAATTTCCTGCA
GAACCCCAAGACTGA	AAACTGAAGCCGAGA	GAGAATTTCCTGCAC
AACCCCAAGACTGAG	AACTGAAGCCGAGAA	AGAATTTCCTGCACA
ACCCCAAGACTGAGG	ACTGAAGCCGAGAAG	GAATTTCCTGCACAA
CCCCAAGACTGAGGT	CTGAAGCCGAGAAGC	AATTTCCTGCACAAC
CCCAAGACTGAGGTG	TGAAGCCGAGAAGCA	ATTTCCTGCACAACT
CCAAGACTGAGGTGT	GAAGCCGAGAAGCAG	TTTCCTGCACAACTC
CAAGACTGAGGTGTG	AAGCCGAGAAGCAGG	TTCCTGCACAACTCC
AAGACTGAGGTGTGT	AGCCGAGAAGCAGGC	TCCTGCACAACTCCA
AGACTGAGGTGTGTG	GCCGAGAAGCAGGCC	CCTGCACAACTCCAT
GACTGAGGTGTGTGG	CCGAGAAGCAGGCCG	CTGCACAACTCCATC
ACTGAGGTGTGTGGT	CGAGAAGCAGGCCGA	TGCACAACTCCATCT
CTGAGGTGTGTGGTG	GAGAAGCAGGCCGAG	GCACAACTCCATCTT
TGAGGTGTGTGGTGG	AGAAGCAGGCCGAGA	CACAACTCCATCTTC
GAGGTGTGTGGTGGG	GAAGCAGGCCGAGAA	ACAACTCCATCTTCG
AGGTGTGTGGTGGGG	AAGCAGGCCGAGAAG	CAACTCCATCTTCGT
GGTGTGTGGTGGGGA	AGCAGGCCGAGAAGG	AACTCCATCTTCGTG
GTGTGTGGTGGGGAG	GCAGGCCGAGAAGGA	ACTCCATCTTCGTGC
TGTGTGGTGGGGAGA	CAGGCCGAGAAGGAG	CTCCATCTTCGTGCC
GTGTGGTGGGGAGAA	AGGCCGAGAAGGAGG	TCCATCTTCGTGCCC
TGTGGTGGGGAGAAA	GGCCGAGAAGGAGGA	CCATCTTCGTGCCCA
GTGGTGGGGAGAAAG	GCCGAGAAGGAGGAG	CATCTTCGTGCCCAG
TGGTGGGGAGAAAGG	CCGAGAAGGAGGAGG	ATCTTCGTGCCCAGA
GGTGGGGAGAAAGGG	CGAGAAGGAGGAGGC	TCTTCGTGCCCAGAC
GTGGGGAGAAAGGGC	GAGAAGGAGGAGGCT	CTTCGTGCCCAGACC
TGGGGAGAAAGGGCC	AGAAGGAGGAGGCTG	TTCGTGCCCAGACCT
GGGGAGAAAGGGCCT	GAAGGAGGAGGCTGA	TCGTGCCCAGACCTG
GGGAGAAAGGGCCTT	AAGGAGGAGGCTGAA	CGTGCCCAGACCTGA
GGAGAAAGGGCCTTG	AGGAGGAGGCTGAAT	GTGCCCAGACCTGAA
GAGAAAGGGCCTTGC	GGAGGAGGCTGAATA	TGCCCAGACCTGAAA
AGAAAGGGCCTTGCT	GAGGAGGCTGAATAC	GCCCAGACCTGAAAG
GAAAGGGCCTTGCTG	AGGAGGCTGAATACC	CCCAGACCTGAAAGG
AAAGGGCCTTGCTGC	GGAGGCTGAATACCG	CCAGACCTGAAAGGA
AAGGGCCTTGCTGCG	GAGGCTGAATACCGC	CAGACCTGAAAGGAA
AGGGCCTTGCTGCGC	AGGCTGAATACCGCA	AGACCTGAAAGGAAG
GGGCCTTGCTGCGCC	GGCTGAATACCGCAA	GACCTGAAAGGAAGC
GGCCTTGCTGCGCCT	GCTGAATACCGCAAA	ACCTGAAAGGAAGCG
GCCTTGCTGCGCCTG	CTGAATACCGCAAAG	CCTGAAAGGAAGCGG
CCTTGCTGCGCCTGC	TGAATACCGCAAAGT	CTGAAAGGAAGCGGA
CTTGCTGCGCCTGCC	GAATACCGCAAAGTC	TGAAAGGAAGCGGAG
TTGCTGCGCCTGCCC	AATACCGCAAAGTCT	GAAAGGAAGCGGAGA
TGCTGCGCCTGCCCC	ATACCGCAAAGTCTT	AAAGGAAGCGGAGAG
GCTGCGCCTGCCCCA	TACCGCAAAGTCTTT	AAGGAAGCGGAGAGA
CTGCGCCTGCCCCAA	ACCGCAAAGTCTTTG	AGGAAGCGGAGAGAT
TGCGCCTGCCCCAAA	CCGCAAAGTCTTTGA	GGAAGCGGAGAGATG
GCGCCTGCCCCAAAA	CGCAAAGTCTTTGAG	GAAGCGGAGAGATGT
CGCCTGCCCCAAAAC	GCAAAGTCTTTGAGA	AAGCGGAGAGATGTC
GCCTGCCCCAAAACT	CAAAGTCTTTGAGAA	AGCGGAGAGATGTCA
CCTGCCCCAAAACTG	AAAGTCTTTGAGAAT	GCGGAGAGATGTCAT
CTGCCCCAAAACTGA	AAGTCTTTGAGAATT	CGGAGAGATGTCATG
TGCCCCAAAACTGAA	AGTCTTTGAGAATTT	GGAGAGATGTCATGC
GCCCCAAAACTGAAG	GTCTTTGAGAATTTC	GAGAGATGTCATGCA
CCCCAAAACTGAAGC	TCTTTGAGAATTTCC	AGAGATGTCATGCAA
CCCAAAACTGAAGCC	CTTTGAGAATTTCCT	GAGATGTCATGCAAG
CCAAAACTGAAGCCG	TTTGAGAATTTCCTG	AGATGTCATGCAAGT
GATGTCATGCAAGTG	CGCAGACACCTACAA	TTGAGAGCAGAGTGG
ATGTCATGCAAGTGG	GCAGACACCTACAAC	TGAGAGCAGAGTGGA
TGTCATGCAAGTGGC	CAGACACCTACAACA	GAGAGCAGAGTGGAT
GTCATGCAAGTGGCC	AGACACCTACAACAT	AGAGCAGAGTGGATA
TCATGCAAGTGGCCA	GACACCTACAACATC	GAGCAGAGTGGATAA
CATGCAAGTGGCCAA	ACACCTACAACATCA	AGCAGAGTGGATAAC
ATGCAAGTGGCCAAC	CACCTACAACATCAC	GCAGAGTGGATAACA
TGCAAGTGGCCAACA	ACCTACAACATCACC	CAGAGTGGATAACAA
GCAAGTGGCCAACAC	CCTACAACATCACCG	AGAGTGGATAACAAG
CAAGTGGCCAACACC	CTACAACATCACCGA	GAGTGGATAACAAGG
AAGTGGCCAACACCA	TACAACATCACCGAC	AGTGGATAACAAGGA
AGTGGCCAACACCAC	ACAACATCACCGACC	GTGGATAACAAGGAG
GTGGCCAACACCACC	CAACATCACCGACCC	TGGATAACAAGGAGA
TGGCCAACACCACCA	AACATCACCGACCCG	GGATAACAAGGAGAG
GGCCAACACCACCAT	ACATCACCGACCCGG	GATAACAAGGAGAGA
GCCAACACCACCATG	CATCACCGACCCGGA	ATAACAAGGAGAGAA
CCAACACCACCATGT	ATCACCGACCCGGAA	TAACAAGGAGAGAAC
CAACACCACCATGTC	TCACCGACCCGGAAG	AACAAGGAGAGAACT
AACACCACCATGTCC	CACCGACCCGGAAGA	ACAAGGAGAGAACTG
ACACCACCATGTCCA	ACCGACCCGGAAGAG	CAAGGAGAGAACTGT
CACCACCATGTCCAG	CCGACCCGGAAGAGC	AAGGAGAGAACTGTC
ACCACCATGTCCAGC	CGACCCGGAAGAGCT	AGGAGAGAACTGTCA
CCACCATGTCCAGCC	GACCCGGAAGAGCTG	GGAGAGAACTGTCAT
CACCATGTCCAGCCG	ACCCGGAAGAGCTGG	GAGAGAACTGTCATT
ACCATGTCCAGCCGA	CCCGGAAGAGCTGGA	AGAGAACTGTCATTT
CCATGTCCAGCCGAA	CCGGAAGAGCTGGAG	GAGAACTGTCATTTC
CATGTCCAGCCGAAG	CGGAAGAGCTGGAGA	AGAACTGTCATTTCT
ATGTCCAGCCGAAGC	GGAAGAGCTGGAGAC	GAACTGTCATTTCTA
TGTCCAGCCGAAGCA	GAAGAGCTGGAGACA	AACTGTCATTTCTAA
GTCCAGCCGAAGCAG	AAGAGCTGGAGACAG	ACTGTCATTTCTAAC
TCCAGCCGAAGCAGG	AGAGCTGGAGACAGA	CTGTCATTTCTAACC
CCAGCCGAAGCAGGA	GAGCTGGAGACAGAG	TGTCATTTCTAACCT
CAGCCGAAGCAGGAA	AGCTGGAGACAGAGT	GTCATTTCTAACCTT
AGCCGAAGCAGGAAC	GCTGGAGACAGAGTA	TCATTTCTAACCTTC
GCCGAAGCAGGAACA	CTGGAGACAGAGTAC	CATTTCTAACCTTCG
CCGAAGCAGGAACAC	TGGAGACAGAGTACC	ATTTCTAACCTTCGG
CGAAGCAGGAACACC	GGAGACAGAGTACCC	TTTCTAACCTTCGGC
GAAGCAGGAACACCA	GAGACAGAGTACCCT	TTCTAACCTTCGGCC
AAGCAGGAACACCAC	AGACAGAGTACCCTT	TCTAACCTTCGGCCT
AGCAGGAACACCACG	GACAGAGTACCCTTT	CTAACCTTCGGCCTT
GCAGGAACACCACGG	ACAGAGTACCCTTTC	TAACCTTCGGCCTTT
CAGGAACACCACGGC	CAGAGTACCCTTTCT	AACCTTCGGCCTTTC
AGGAACACCACGGCC	AGAGTACCCTTTCTT	ACCTTCGGCCTTTCA
GGAACACCACGGCCG	GAGTACCCTTTCTTT	CCTTCGGCCTTTCAC
GAACACCACGGCCGC	AGTACCCTTTCTTTG	CTTCGGCCTTTCACA
AACACCACGGCCGCA	GTACCCTTTCTTTGA	TTCGGCCTTTCACAT
ACACCACGGCCGCAG	TACCCTTTCTTTGAG	TCGGCCTTTCACATT
CACCACGGCCGCAGA	ACCCTTTCTTTGAGA	CGGCCTTTCACATTG
ACCACGGCCGCAGAC	CCCTTTCTTTGAGAG	GGCCTTTCACATTGT
CCACGGCCGCAGACA	CCTTTCTTTGAGAGC	GCCTTTCACATTGTA
CACGGCCGCAGACAC	CTTTCTTTGAGAGCA	CCTTTCACATTGTAC
ACGGCCGCAGACACC	TTTCTTTGAGAGCAG	CTTTCACATTGTACC
CGGCCGCAGACACCT	TTCTTTGAGAGCAGA	TTTCACATTGTACCG
GGCCGCAGACACCTA	TCTTTGAGAGCAGAG	TTCACATTGTACCGC
GCCGCAGACACCTAC	CTTTGAGAGCAGAGT	TCACATTGTACCGCA
CCGCAGACACCTACA	TTTGAGAGCAGAGTG	CACATTGTACCGCAT
ACATTGTACCGCATC	CAGCGCCTCCAACTT	TTCCTGGGCCAGTGA
CATTGTACCGCATCG	AGCGCCTCCAACTTC	TCCTGGGCCAGTGAC
ATTGTACCGCATCGA	GCGCCTCCAACTTCG	CCTGGGCCAGTGACC
TTGTACCGCATCGAT	CGCCTCCAACTTCGT	CTGGGCCAGTGACCT
TGTACCGCATCGATA	GCCTCCAACTTCGTC	TGGGCCAGTGACCTG
GTACCGCATCGATAT	CCTCCAACTTCGTCT	GGGCCAGTGACCTGG
TACCGCATCGATATC	CTCCAACTTCGTCTT	GGCCAGTGACCTGGG
ACCGCATCGATATCC	TCCAACTTCGTCTTT	GCCAGTGACCTGGGA
CCGCATCGATATCCA	CCAACTTCGTCTTTG	CCAGTGACCTGGGAG
CGCATCGATATCCAC	CAACTTCGTCTTTGC	CAGTGACCTGGGAGC
GCATCGATATCCACA	AACTTCGTCTTTGCA	AGTGACCTGGGAGCC
CATCGATATCCACAG	ACTTCGTCTTTGCAA	GTGACCTGGGAGCCA
ATCGATATCCACAGC	CTTCGTCTTTGCAAG	TGACCTGGGAGCCAA
TCGATATCCACAGCT	TTCGTCTTTGCAAGG	GACCTGGGAGCCAAG
CGATATCCACAGCTG	TCGTCTTTGCAAGGA	ACCTGGGAGCCAAGG
GATATCCACAGCTGC	CGTCTTTGCAAGGAC	CCTGGGAGCCAAGGC
ATATCCACAGCTGCA	GTCTTTGCAAGGACT	CTGGGAGCCAAGGCC
TATCCACAGCTGCAA	TCTTTGCAAGGACTA	TGGGAGCCAAGGCCT
ATCCACAGCTGCAAC	CTTTGCAAGGACTAT	GGGAGCCAAGGCCTG
TCCACAGCTGCAACC	TTTGCAAGGACTATG	GGAGCCAAGGCCTGA
CCACAGCTGCAACCA	TTGCAAGGACTATGC	GAGCCAAGGCCTGAA
CACAGCTGCAACCAC	TGCAAGGACTATGCC	AGCCAAGGCCTGAAA
ACAGCTGCAACCACG	GCAAGGACTATGCCC	GCCAAGGCCTGAAAA
CAGCTGCAACCACGA	CAAGGACTATGCCCG	CCAAGGCCTGAAAAC
AGCTGCAACCACGAG	AAGGACTATGCCCGC	CAAGGCCTGAAAACT
GCTGCAACCACGAGG	AGGACTATGCCCGCA	AAGGCCTGAAAACTC
CTGCAACCACGAGGC	GGACTATGCCCGCAG	AGGCCTGAAAACTCC
TGCAACCACGAGGCT	GACTATGCCCGCAGA	GGCCTGAAAACTCCA
GCAACCACGAGGCTG	ACTATGCCCGCAGAA	GCCTGAAAACTCCAT
CAACCACGAGGCTGA	CTATGCCCGCAGAAG	CCTGAAAACTCCATC
AACCACGAGGCTGAG	TATGCCCGCAGAAGG	CTGAAAACTCCATCT
ACCACGAGGCTGAGA	ATGCCCGCAGAAGGA	TGAAAACTCCATCTT
CCACGAGGCTGAGAA	TGCCCGCAGAAGGAG	GAAAACTCCATCTTT
CACGAGGCTGAGAAG	GCCCGCAGAAGGAGC	AAAACTCCATCTTTT
ACGAGGCTGAGAAGC	CCCGCAGAAGGAGCA	AAACTCCATCTTTTT
CGAGGCTGAGAAGCT	CCGCAGAAGGAGCAG	AACTCCATCTTTTTA
GAGGCTGAGAAGCTG	CGCAGAAGGAGCAGA	ACTCCATCTTTTTAA
AGGCTGAGAAGCTGG	GCAGAAGGAGCAGAT	CTCCATCTTTTTAAA
GGCTGAGAAGCTGGG	CAGAAGGAGCAGATG	TCCATCTTTTTAAAG
GCTGAGAAGCTGGGC	AGAAGGAGCAGATGA	CCATCTTTTTAAAGT
CTGAGAAGCTGGGCT	GAAGGAGCAGATGAC	CATCTTTTTAAAGTG
TGAGAAGCTGGGCTG	AAGGAGCAGATGACA	ATCTTTTTAAAGTGG
GAGAAGCTGGGCTGC	AGGAGCAGATGACAT	TCTTTTTAAAGTGGC
AGAAGCTGGGCTGCA	GGAGCAGATGACATT	CTTTTTAAAGTGGCC
GAAGCTGGGCTGCAG	GAGCAGATGACATTC	TTTTTAAAGTGGCCG
AAGCTGGGCTGCAGC	AGCAGATGACATTCC	TTTTAAAGTGGCCGG
AGCTGGGCTGCAGCG	GCAGATGACATTCCT	TTTAAAGTGGCCGGA
GCTGGGCTGCAGCGC	CAGATGACATTCCTG	TTAAAGTGGCCGGAA
CTGGGCTGCAGCGCC	AGATGACATTCCTGG	TAAAGTGGCCGGAAC
TGGGCTGCAGCGCCT	GATGACATTCCTGGG	AAAGTGGCCGGAACC
GGGCTGCAGCGCCTC	ATGACATTCCTGGGC	AAGTGGCCGGAACCT
GGCTGCAGCGCCTCC	TGACATTCCTGGGCC	AGTGGCCGGAACCTG
GCTGCAGCGCCTCCA	GACATTCCTGGGCCA	GTGGCCGGAACCTGA
CTGCAGCGCCTCCAA	ACATTCCTGGGCCAG	TGGCCGGAACCTGAG
TGCAGCGCCTCCAAC	CATTCCTGGGCCAGT	GGCCGGAACCTGAGA
GCAGCGCCTCCAACT	ATTCCTGGGCCAGTG	GCCGGAACCTGAGAA
CCGGAACCTGAGAAT	ACAAGTTGAGGATCA	GGGCCAAGCTAAACC
CGGAACCTGAGAATC	CAAGTTGAGGATCAG	GGCCAAGCTAAACCG
GGAACCTGAGAATCC	AAGTTGAGGATCAGC	GCCAAGCTAAACCGG
GAACCTGAGAATCCC	AGTTGAGGATCAGCG	CCAAGCTAAACCGGC
AACCTGAGAATCCCA	GTTGAGGATCAGCGA	CAAGCTAAACCGGCT
ACCTGAGAATCCCAA	TTGAGGATCAGCGAG	AAGCTAAACCGGCTA
CCTGAGAATCCCAAT	TGAGGATCAGCGAGA	AGCTAAACCGGCTAA
CTGAGAATCCCAATG	GAGGATCAGCGAGAA	GCTAAACCGGCTAAA
TGAGAATCCCAATGG	AGGATCAGCGAGAAT	CTAAACCGGCTAAAC
GAGAATCCCAATGGA	GGATCAGCGAGAATG	TAAACCGGCTAAACC
AGAATCCCAATGGAT	GATCAGCGAGAATGT	AAACCGGCTAAACCC
GAATCCCAATGGATT	ATCAGCGAGAATGTG	AACCGGCTAAACCCG
AATCCCAATGGATTG	TCAGCGAGAATGTGT	ACCGGCTAAACCCGG
ATCCCAATGGATTGA	CAGCGAGAATGTGTG	CCGGCTAAACCCGGG
TCCCAATGGATTGAT	AGCGAGAATGTGTGT	CGGCTAAACCCGGGG
CCCAATGGATTGATT	GCGAGAATGTGTGTC	GGCTAAACCCGGGGA
CCAATGGATTGATTC	CGAGAATGTGTGTCC	GCTAAACCCGGGGAA
CAATGGATTGATTCT	GAGAATGTGTGTCCA	CTAAACCCGGGGAAC
AATGGATTGATTCTA	AGAATGTGTGTCCAG	TAAACCCGGGGAACT
ATGGATTGATTCTAA	GAATGTGTGTCCAGA	AAACCCGGGGAACTA
TGGATTGATTCTAAT	AATGTGTGTCCAGAC	AACCCGGGGAACTAC
GGATTGATTCTAATG	ATGTGTGTCCAGACA	ACCCGGGGAACTACA
GATTGATTCTAATGT	TGTGTGTCCAGACAG	CCCGGGGAACTACAC
ATTGATTCTAATGTA	GTGTGTCCAGACAGG	CCGGGGAACTACACA
TTGATTCTAATGTAT	TGTGTCCAGACAGGA	CGGGGAACTACACAG
TGATTCTAATGTATG	GTGTCCAGACAGGAA	GGGGAACTACACAGC
GATTCTAATGTATGA	TGTCCAGACAGGAAT	GGGAACTACACAGCC
ATTCTAATGTATGAA	GTCCAGACAGGAATA	GGAACTACACAGCCC
TTCTAATGTATGAAA	TCCAGACAGGAATAC	GAACTACACAGCCCG
TCTAATGTATGAAAT	CCAGACAGGAATACA	AACTACACAGCCCGG
CTAATGTATGAAATA	CAGACAGGAATACAG	ACTACACAGCCCGGA
TAATGTATGAAATAA	AGACAGGAATACAGG	CTACACAGCCCGGAT
AATGTATGAAATAAA	GACAGGAATACAGGA	TACACAGCCCGGATT
ATGTATGAAATAAAA	ACAGGAATACAGGAA	ACACAGCCCGGATTC
TGTATGAAATAAAAT	CAGGAATACAGGAAG	CACAGCCCGGATTCA
GTATGAAATAAAATA	AGGAATACAGGAAGT	ACAGCCCGGATTCAG
TATGAAATAAAATAC	GGAATACAGGAAGTA	CAGCCCGGATTCAGG
ATGAAATAAAATACG	GAATACAGGAAGTAT	AGCCCGGATTCAGGC
TGAAATAAAATACGG	AATACAGGAAGTATG	GCCCGGATTCAGGCC
GAAATAAAATACGGA	ATACAGGAAGTATGG	CCCGGATTCAGGCCA
AAATAAAATACGGAT	TACAGGAAGTATGGA	CCGGATTCAGGCCAC
AATAAAATACGGATC	ACAGGAAGTATGGAG	CGGATTCAGGCCACA
ATAAAATACGGATCA	CAGGAAGTATGGAGG	GGATTCAGGCCACAT
TAAAATACGGATCAC	AGGAAGTATGGAGGG	GATTCAGGCCACATC
AAAATACGGATCACA	GGAAGTATGGAGGGG	ATTCAGGCCACATCT
AAATACGGATCACAA	GAAGTATGGAGGGGC	TTCAGGCCACATCTC
AATACGGATCACAAG	AAGTATGGAGGGGCC	TCAGGCCACATCTCT
ATACGGATCACAAGT	AGTATGGAGGGGCCA	CAGGCCACATCTCTC
TACGGATCACAAGTT	GTATGGAGGGGCCAA	AGGCCACATCTCTCT
ACGGATCACAAGTTG	TATGGAGGGGCCAAG	GGCCACATCTCTCTC
CGGATCACAAGTTGA	ATGGAGGGGCCAAGC	GCCACATCTCTCTCT
GGATCACAAGTTGAG	TGGAGGGGCCAAGCT	CCACATCTCTCTCTG
GATCACAAGTTGAGG	GGAGGGGCCAAGCTA	CACATCTCTCTCTGG
ATCACAAGTTGAGGA	GAGGGGCCAAGCTAA	ACATCTCTCTCTGGG
TCACAAGTTGAGGAT	AGGGGCCAAGCTAAA	CATCTCTCTCTGGGA
CACAAGTTGAGGATC	GGGGCCAAGCTAAAC	ATCTCTCTCTGGGAA
TCTCTCTCTGGGAAT	AACAGGATATGAAAA	TGATCGTGGGAGGGT
CTCTCTCTGGGAATG	ACAGGATATGAAAAC	GATCGTGGGAGGGTT
TCTCTCTGGGAATGG	CAGGATATGAAAACT	ATCGTGGGAGGGTTG
CTCTCTGGGAATGGG	AGGATATGAAAACTT	TCGTGGGAGGGTTGG
TCTCTGGGAATGGGT	GGATATGAAAACTTC	CGTGGGAGGGTTGGT
CTCTGGGAATGGGTC	GATATGAAAACTTCA	GTGGGAGGGTTGGTG
TCTGGGAATGGGTCG	ATATGAAAACTTCAT	TGGGAGGGTTGGTGA
CTGGGAATGGGTCGT	TATGAAAACTTCATC	GGGAGGGTTGGTGAT
TGGGAATGGGTCGTG	ATGAAAACTTCATCC	GGAGGGTTGGTGATT
GGGAATGGGTCGTGG	TGAAAACTTCATCCA	GAGGGTTGGTGATTA
GGAATGGGTCGTGGA	GAAAACTTCATCCAT	AGGGTTGGTGATTAT
GAATGGGTCGTGGAC	AAAACTTCATCCATC	GGGTTGGTGATTATG
AATGGGTCGTGGACA	AAACTTCATCCATCT	GGTTGGTGATTATGC
ATGGGTCGTGGACAG	AACTTCATCCATCTG	GTTGGTGATTATGCT
TGGGTCGTGGACAGA	ACTTCATCCATCTGA	TTGGTGATTATGCTG
GGGTCGTGGACAGAT	CTTCATCCATCTGAT	TGGTGATTATGCTGT
GGTCGTGGACAGATC	TTCATCCATCTGATC	GGTGATTATGCTGTA
GTCGTGGACAGATCC	TCATCCATCTGATCA	GTGATTATGCTGTAC
TCGTGGACAGATCCT	CATCCATCTGATCAT	TGATTATGCTGTACG
CGTGGACAGATCCTG	ATCCATCTGATCATC	GATTATGCTGTACGT
GTGGACAGATCCTGT	TCCATCTGATCATCG	ATTATGCTGTACGTC
TGGACAGATCCTGTG	CCATCTGATCATCGC	TTATGCTGTACGTCT
GGACAGATCCTGTGT	CATCTGATCATCGCT	TATGCTGTACGTCTT
GACAGATCCTGTGTT	ATCTGATCATCGCTC	ATGCTGTACGTCTTC
ACAGATCCTGTGTTC	TCTGATCATCGCTCT	TGCTGTACGTCTTCC
CAGATCCTGTGTTCT	CTGATCATCGCTCTG	GCTGTACGTCTTCCA
AGATCCTGTGTTCTT	TGATCATCGCTCTGC	CTGTACGTCTTCCAT
GATCCTGTGTTCTTC	GATCATCGCTCTGCC	TGTACGTCTTCCATA
ATCCTGTGTTCTTCT	ATCATCGCTCTGCCC	GTACGTCTTCCATAG
TCCTGTGTTCTTCTA	TCATCGCTCTGCCCG	TACGTCTTCCATAGA
CCTGTGTTCTTCTAT	CATCGCTCTGCCCGT	ACGTCTTCCATAGAA
CTGTGTTCTTCTATG	ATCGCTCTGCCCGTC	CGTCTTCCATAGAAA
TGTGTTCTTCTATGT	TCGCTCTGCCCGTCG	GTCTTCCATAGAAAG
GTGTTCTTCTATGTC	CGCTCTGCCCGTCGC	TCTTCCATAGAAAGA
TGTTCTTCTATGTCC	GCTCTGCCCGTCGCT	CTTCCATAGAAAGAG
GTTCTTCTATGTCCA	CTCTGCCCGTCGCTG	TTCCATAGAAAGAGA
TTCTTCTATGTCCAG	TCTGCCCGTCGCTGT	TCCATAGAAAGAGAA
TCTTCTATGTCCAGG	CTGCCCGTCGCTGTC	CCATAGAAAGAGAAA
CTTCTATGTCCAGGC	TGCCCGTCGCTGTCC	CATAGAAAGAGAAAT
TTCTATGTCCAGGCC	GCCCGTCGCTGTCCT	ATAGAAAGAGAAATA
TCTATGTCCAGGCCA	CCCGTCGCTGTCCTG	TAGAAAGAGAAATAA
CTATGTCCAGGCCAA	CCGTCGCTGTCCTGT	AGAAAGAGAAATAAC
TATGTCCAGGCCAAA	CGTCGCTGTCCTGTT	GAAAGAGAAATAACA
ATGTCCAGGCCAAAA	GTCGCTGTUCTGTTG	AAAGAGAAATAACAG
TGTCCAGGCCAAAAC	TCGCTGTCCTGTTGA	AAGAGAAATAACAGC
GTCCAGGCCAAAACA	CGCTGTCCTGTTGAT	AGAGAAATAACAGCA
TCCAGGCCAAAACAG	GCTGTCCTGTTGATC	GAGAAATAACAGCAG
CCAGGCCAAAACAGG	CTGTCCTGTTGATCG	AGAAATAACAGCAGG
CAGGCCAAAACAGGA	TGTCCTGTTGATCGT	GAAATAACAGCAGGC
AGGCCAAAACAGGAT	GTCCTGTTGATCGTG	AAATAACAGCAGGCT
GGCCAAAACAGGATA	TCCTGTTGATCGTGG	AATAACAGCAGGCTG
GCCAAAACAGGATAT	CCTGTTGATCGTGGG	ATAACAGCAGGCTGG
CCAAAACAGGATATG	CTGTTGATCGTGGGA	TAACAGCAGGCTGGG
CAAAACAGGATATGA	TGTTGATCGTGGGAG	AACAGCAGGCTGGGG
AAAACAGGATATGAA	GTTGATCGTGGGAGG	ACAGCAGGCTGGGGA
AAACAGGATATGAAA	TTGATCGTGGGAGGG	CAGCAGGCTGGGGAA
AGCAGGCTGGGGAAT	TGCTGATGTGTACGT	GCCGGGAACTTGGGC
GCAGGCTGGGGAATG	GCTGATGTGTACGTT	CCGGGAACTTGGGCA
CAGGCTGGGCAATGG	CTGATGTGTACGTTC	CGGGAACTTGGGCAG
AGGCTGGGGAATGGA	TGATGTGTACGTTCC	GGGAACTTGGGCAGG
GGCTGGGGAATGGAG	GATGTGTACGTTCCT	GGAACTTGGGCAGGG
GCTGGGGAATGGAGT	ATGTGTACGTTCCTG	GAACTTGGGCAGGGG
CTGGGGAATGGAGTG	TGTGTACGTTCCTGA	AACTTGGGCAGGGGT
TGGGGAATGGAGTGC	GTGTACGTTCCTGAT	ACTTGGGCAGGGGTC
GGGGAATGGAGTGCT	TGTACGTTCCTGATG	CTTGGGCAGGGGTCG
GGGAATGGAGTGCTG	GTACGTTCCTGATGA	TTGGGCAGGGGTCGT
GGAATGGAGTGCTGT	TACGTTCCTGATGAG	TGGGCAGGGGTCGTT
GAATGGAGTGCTGTA	ACGTTCCTGATGAGT	GGGCAGGGGTCGTTT
AATGGAGTGCTGTAT	CGTTCCTGATGAGTG	GGCAGGGGTCGTTTG
ATGGAGTGCTGTATG	GTTCCTGATGAGTGG	GCAGGGGTCGTTTGG
TGGAGTGCTGTATGC	TTCCTGATGAGTGGG	CAGGGGTCGTTTGGG
GGAGTGCTGTATGCC	TCCTGATGAGTGGGA	AGGGGTCGTTTGGGA
GAGTGCTGTATGCCT	CCTGATGAGTGGGAG	GGGGTCGTTTGGGAT
AGTGCTGTATGCCTC	CTGATGAGTGGGAGG	GGGTCGTTTGGGATG
GTGCTGTATGCCTCT	TGATGAGTGGGAGGT	GGTCGTTTGGGATGG
TGCTGTATGCCTCTG	GATGAGTGGGAGGTG	GTCGTTTGGGATGGT
GCTGTATGCCTCTGT	ATGAGTGGGAGGTGG	TCGTTTGGGATGGTC
CTGTATGCCTCTGTG	TGAGTGGGAGGTGGC	CGTTTGGGATGGTCT
TGTATGCCTCTGTGA	GAGTGGGAGGTGGCT	GTTTGGGATGGTCTA
GTATGCCTCTGTGAA	AGTGGGAGGTGGCTC	TTTGGGATGGTCTAT
TATGCCTCTGTGAAC	GTGGGAGGTGGCTCG	TTGGGATGGTCTATG
ATGCCTCTGTGAACC	TGGGAGGTGGCTCGG	TGGGATGGTCTATGA
TGCCTCTGTGAACCC	GGGAGGTGGCTCGGG	GGGATGGTCTATGAA
GCCTCTGTGAACCCG	GGAGGTGGCTCGGGA	GGATGGTCTATGAAG
CCTCTGTGAACCCGG	GAGGTGGCTCGGGAG	GATGGTCTATGAAGG
CTCTGTGAACCCGGA	AGGTGGCTCGGGAGA	ATGGTCTATGAAGGA
TCTGTGAACCCGGAG	GGTGGCTCGGGAGAA	TGGTCTATGAAGGAG
CTGTGAACCCGGAGT	GTGGCTCGGGAGAAG	GGTCTATGAAGGAGT
TGTGAACCCGGAGTA	TGGCTCGGGAGAAGA	GTCTATGAAGGAGTT
GTGAACCCGGAGTAC	GGCTCGGGAGAAGAT	TCTATGAAGGAGTTG
TGAACCCGGAGTACT	GCTCGGGAGAAGATC	CTATGAAGGAGTTGC
GAACCCGGAGTACTT	CTCGGGAGAAGATCA	TATGAAGGAGTTGCC
AACCCGGAGTACTTC	TCGGGAGAAGATCAC	ATGAAGGAGTTGCCA
ACCCGGAGTACTTCA	CGGGAGAAGATCACC	TGAAGGAGTTGCCAA
CCCGGAGTACTTCAG	GGGAGAAGATCACCA	GAAGGAGTTGCCAAG
CCGGAGTACTTCAGC	GGAGAAGATCACCAT	AAGGAGTTGCCAAGG
CGGAGTACTTCAGCG	GAGAAGATCACCATG	AGGAGTTGCCAAGGG
GGAGTACTTCAGCGC	AGAAGATCACCATGA	GGAGTTGCCAAGGGT
GAGTACTTCAGCGCT	GAAGATCACCATGAG	GAGTTGCCAAGGGTG
AGTACTTCAGCGCTG	AAGATCACCATGAGC	AGTTGCCAAGGGTGT
GTACTTCAGCGCTGC	AGATCACCATGAGCC	GTTGCCAAGGGTGTG
TACTTCAGCGCTGCT	GATCACCATGAGCCG	TTGCCAAGGGTGTGG
ACTTCAGCGCTGCTG	ATCACCATGAGCCGG	TGCCAAGGGTGTGGT
CTTCAGCGCTGCTGA	TCACCATGAGCCGGG	GCCAAGGGTGTGGTG
TTCAGCGCTGCTGAT	CACCATGAGCCGGGA	CCAAGGGTGTGGTGA
TCAGCGCTGCTGATG	ACCATGAGCCGGGAA	CAAGGGTGTGGTGAA
CAGCGCTGCTGATGT	CCATGAGCCGGGAAC	AAGGGTGTGGTGAAA
AGCGCTGCTGATGTG	CATGAGCCGGGAACT	AGGGTGTGGTGAAAG
GCGCTGCTGATGTGT	ATGAGCCGGGAACTT	GGGTGTGGTGAAAGA
CGCTGCTGATGTGTA	TGAGCCGGGAACTTG	GGTGTGGTGAAAGAT
GCTGCTGATGTGTAC	GAGCCGGGAACTTGG	GTGTGGTGAAAGATG
CTGCTGATGTGTACG	AGCCGGGAACTTGGG	TGTGGTGAAAGATGA
GTGGTGAAAGATCAA	AAGCATGCGTGAGAG	ATTGTCACCATGTGG
TGGTGAAAGATGAAC	AGCATGCGTGAGAGG	TTGTCACCATGTGGT
GGTGAAAGATGAACC	GCATGCGTGAGAGGA	TGTCACCATGTGGTG
GTGAAAGATGAACCT	CATGCGTGAGAGGAT	GTCACCATGTGGTGC
TGAAAGATGAACCTG	ATGCGTGAGAGGATT	TCACCATGTGGTGCG
GAAAGATGAACCTGA	TGCGTGAGAGGATTG	CACCATGTGGTGCGA
AAAGATGAACCTGAA	GCGTGAGAGGATTGA	ACCATGTGGTGCGAT
AAGATGAACCTGAAA	CGTGAGAGGATTGAG	CCATGTGGTGCGATT
AGATGAACCTGAAAC	GTGAGAGGATTGAGT	CATGTGGTGCGATTG
GATGAACCTGAAACC	TGAGAGGATTGAGTT	ATGTGGTGCGATTGC
ATGAACCTGAAACCA	GAGAGGATTGAGTTT	TGTGGTGCGATTGCT
TGAACCTGAAACCAG	AGAGGATTGAGTTTC	GTGGTGCGATTGCTG
GAACCTGAAACCAGA	GAGGATTGAGTTTCT	TGGTGCGATTGCTGG
AACCTGAAACCAGAG	AGGATTGAGTTTCTC	GGTGCGATTGCTGGG
ACCTGAAACCAGAGT	GGATTGAGTTTCTCA	GTGCGATTGCTGGGT
CCTGAAACCAGAGTG	GATTGAGTTTCTCAA	TGCGATTGCTGGGTG
CTGAAACCAGAGTGG	ATTGAGTTTCTCAAC	GCGATTGCTGGGTGT
TGAAACCAGAGTGGC	TTGAGTTTCTCAACG	CGATTGCTGGGTGTG
GAAACCAGAGTGGCC	TGAGTTTCTCAACGA	GATTGCTGGGTGTGG
AAACCAGAGTGGCCA	GAGTTTCTCAACGAA	ATTGCTGGGTGTGGT
AACCAGAGTGGCCAT	AGTTTCTCAACGAAG	TTGCTGGGTGTGGTG
ACCAGAGTGGCCATT	GTTTCTCAACGAAGC	TGCTGGGTGTGGTGT
CCAGAGTGGCCATTA	TTTCTCAACGAAGCT	GCTGGGTGTGGTGTC
CAGAGTGGCCATTAA	TTCTCAACGAAGCTT	CTGGGTGTGGTGTCC
AGAGTGGCCATTAAA	TCTCAACGAAGCTTC	TGGGTGTGGTGTCCC
GAGTGGCCATTAAAA	CTCAACGAAGCTTCT	GGGTGTGGTGTCCCA
AGTGGCCATTAAAAC	TCAACGAAGCTTCTG	GGTGTGGTGTCCCAA
GTGGCCATTAAAACA	CAACGAAGCTTCTGT	GTGTGGTGTCCCAAG
TGGCCATTAAAACAG	AACGAAGCTTCTGTG	TGTGGTGTCCCAAGG
GGCCATTAAAACAGT	ACGAAGCTTCTGTGA	GTGGTGTCCCAAGGC
GCCATTAAAACAGTG	CGAAGCTTCTGTGAT	TGGTGTCCCAAGGCC
CCATTAAAACAGTGA	GAAGCTTCTGTGATG	GGTGTCCCAAGGCCA
CATTAAAACAGTGAA	AAGCTTCTGTGATGA	GTGTCCCAAGGCCAG
ATTAAAACAGTGAAC	AGCTTCTGTGATGAA	TGTCCCAAGGCCAGC
TTAAAACAGTGAACG	GCTTCTGTGATGAAG	GTCCCAAGGCCAGCC
TAAAACAGTGAACGA	CTTCTGTGATGAAGG	TCCCAAGGCCAGCCA
AAAACAGTGAACGAG	TTCTGTGATGAAGGA	CCCAAGGCCAGCCAA
AAACAGTGAACGAGG	TCTGTGATGAAGGAG	CCAAGGCCAGCCAAC
AACAGTGAACGAGGC	CTGTGATGAAGGAGT	CAAGGCCAGCCAACA
ACAGTGAACGAGGCC	TGTGATGAAGGAGTT	AAGGCCAGCCAACAC
CAGTGAACGAGGCCG	GTGATGAAGGAGTTC	AGGCCAGCCAACACT
AGTGAACGAGGCCGC	TGATGAAGGAGTTCA	GGCCAGCCAACACTG
GTGAACGAGGCCGCA	GATGAAGGAGTTCAA	GCCAGCCAACACTGG
TGAACGAGGCCGCAA	ATGAAGGAGTTCAAT	CCAGCCAACACTGGT
GAACGAGGCCGCAAG	TGAAGGAGTTCAATT	CAGCCAACACTGGTC
AACGAGGCCGCAAGC	GAAGGAGTTCAATTG	AGCCAACACTGGTCA
ACGAGGCCGCAAGCA	AAGGAGTTCAATTGT	GCCAACACTGGTCAT
CGAGGCCGCAAGCAT	AGGAGTTCAATTGTC	CCAACACTGGTCATC
GAGGCCGCAAGCATG	GGAGTTCAATTGTCA	CAACACTGGTCATCA
AGGCCGCAAGCATGC	GAGTTCAATTGTCAC	AACACTGGTCATCAT
GGCCGCAAGCATGCG	AGTTCAATTGTCACC	ACACTGGTCATCATG
GCCGCAAGCATGCGT	GTTCAATTGTCACCA	CACTGGTCATCATGG
CCGCAAGCATGCGTG	TTCAATTGTCACCAT	ACTGGTCATCATGGA
CGCAAGCATGCGTGA	TCAATTGTCACCATG	CTGGTCATCATGGAA
GCAAGCATGCGTGAG	CAATTGTCACCATGT	TGGTCATCATGGAAC
CAAGCATGCGTGAGA	AATTGTCACCATGTG	GGTCATCATGGAACT
GTCATCATGGAACTG	GCCAGAAATGGAGAA	AGATGGCCGGAGAGA
TCATCATGGAACTGA	CCAGAAATGGAGAAT	GATGGCCGGAGAGAT
CATCATGGAACTGAT	CAGAAATGGAGAATA	ATGGCCGGAGAGATT
ATCATGGAACTGATG	AGAAATGGAGAATAA	TGGCCGGAGAGATTG
TCATGGAACTGATGA	GAAATGGAGAATAAT	GGCCGGAGAGATTGC
CATGGAACTGATGAC	AAATGGAGAATAATC	GCCGGAGAGATTGCA
ATGGAACTGATGACA	AATGGAGAATAATCC	CCGGAGAGATTGCAG
TGGAACTGATGACAC	ATGGAGAATAATCCA	CGGAGAGATTGCAGA
GGAACTGATGACACG	TGGAGAATAATCCAG	GGAGAGATTGCAGAC
GAACTGATGACACGG	GGAGAATAATCCAGT	GAGAGATTGCAGACG
AACTGATGACACGGG	GAGAATAATCCAGTC	AGAGATTGCAGACGG
ACTGATGACACGGGG	AGAATAATCCAGTCC	GAGATTGCAGACGGC
CTGATGACACGGGGC	GAATAATCCAGTCCT	AGATTGCAGACGGCA
TGATGACACGGGGCG	AATAATCCAGTCCTA	GATTGCAGACGGCAT
GATGACACGGGGCGA	ATAATCCAGTCCTAG	ATTGCAGACGGCATG
ATGACACGGGGCGAT	TAATCCAGTCCTAGC	TTGCAGACGGCATGG
TGACACGGGGCGATC	AATCCAGTCCTAGCA	TGCAGACGGCATGGC
GACACGGGGCGATCT	ATCCAGTCCTAGCAC	GCAGACGGCATGGCA
ACACGGGGCGATCTC	TCCAGTCCTAGCACC	CAGACGGCATGGCAT
CACGGGGCGATCTCA	CCAGTCCTAGCACCT	AGACGGCATGGCATA
ACGGGGCGATCTCAA	CAGTCCTAGCACCTC	GACGGCATGGCATAC
CGGGGCGATCTCAAA	AGTCCTAGCACCTCC	ACGGCATGGCATACC
GGGGCGATCTCAAAA	GTCCTAGCACCTCCA	CGGCATGGCATACCT
GGGCGATCTCAAAAG	TCCTAGCACCTCCAA	GGCATGGCATACCTC
GGCGATCTCAAAAGT	CCTAGCACCTCCAAG	GCATGGCATACCTCA
GCGATCTCAAAAGTT	CTAGCACCTCCAAGC	CATGGCATACCTCAA
CGATCTCAAAAGTTA	TAGCACCTCCAAGCC	ATGGCATACCTCAAC
GATCTCAAAAGTTAT	AGCACCTCCAAGCCT	TGGCATACCTCAACG
ATCTCAAAAGTTATC	GCACCTCCAAGCCTG	GGCATACCTCAACGC
TCTCAAAAGTTATCT	CACCTCCAAGCCTGA	GCATACCTCAACGCC
CTCAAAAGTTATCTC	ACCTCCAAGCCTGAG	CATACCTCAACGCCA
TCAAAAGTTATCTCC	CCTCCAAGCCTGAGC	ATACCTCAACGCCAA
CAAAAGTTATCTCCG	CTCCAAGCCTGAGCA	TACCTCAACGCCAAT
AAAAGTTATCTCCGG	TCCAAGCCTGAGCAA	ACCTCAACGCCAATA
AAAGTTATCTCCGGT	CCAAGCCTGAGCAAG	CCTCAACGCCAATAA
AAGTTATCTCCGGTC	CAAGCCTGAGCAAGA	CTCAACGCCAATAAG
AGTTATCTCCGGTCT	AAGCCTGAGCAAGAT	TCAACGCCAATAAGT
GTTATCTCCGGTCTC	AGCCTGAGCAAGATG	CAACGCCAATAAGTT
TTATCTCCGGTCTCT	GCCTGAGCAAGATGA	AACGCCAATAAGTTC
TATCTCCGGTCTCTG	CCTGAGCAAGATGAT	ACGCCAATAAGTTCG
ATCTCCGGTCTCTGA	CTGAGCAAGATGATT	CGCCAATAAGTTCGT
TCTCCGGTCTCTGAG	TGAGCAAGATGATTC	GCCAATAAGTTCGTC
CTCCGGTCTCTGAGG	GAGCAAGATGATTCA	CCAATAAGTTCGTCC
TCCGGTCTCTGAGGC	AGCAAGATGATTCAG	CAATAAGTTCGTCCA
CCGGTCTCTGAGGCC	GCAAGATGATTCAGA	AATAAGTTCGTCCAC
CGGTCTCTGAGGCCA	CAAGATGATTCAGAT	ATAAGTTCGTCCACA
GGTCTCTGAGGCCAG	AAGATGATTCAGATG	TAAGTTCGTCCACAG
GTCTCTGAGGCCAGA	AGATGATTCAGATGG	AAGTTCGTCCACAGA
TCTCTGAGGCCAGAA	GATGATTCAGATGGC	AGTTCGTCCACAGAG
CTCTGAGGCCAGAAA	ATGATTCAGATGGCC	GTTCGTCCACAGAGA
TCTGAGGCCAGAAAT	TGATTCAGATGGCCG	TTCGTCCACAGAGAC
CTGAGGCCAGAAATG	GATTCAGATGGCCGG	TCGTCCACAGAGACC
TGAGGCCAGAAATGG	ATTCAGATGGCCGGA	CGTCCACAGAGACCT
GAGGCCAGAAATGGA	TTCAGATGGCCGGAG	GTCCACAGAGACCTT
AGGCCAGAAATGGAG	TCAGATGGCCGGAGA	TCCACAGAGACCTTG
GGCCAGAAATGGAGA	CAGATGGCCGGAGAG	CCACAGAGACCTTGC
CACAGAGACCTTGCT	CGGAGATTTTGGTAT	GCAAAGGGCTGCTGC
ACAGAGACCTTGCTG	GGAGATTTTGGTATG	CAAAGGGCTGCTGCC
CAGAGACCTTGCTGC	GAGATTTTGGTATGA	AAAGGGCTGCTGCCC
AGAGACCTTGCTGCC	AGATTTTGGTATGAC	AAGGGCTGCTGCCCG
GAGACCTTGCTGCCC	GATTTTGGTATGACG	AGGGCTGCTGCCCGT
AGACCTTGCTGCCCG	ATTTTGGTATGACGC	GGGCTGCTGCCCGTG
GACCTTGCTGCCCGG	TTTTGGTATGACGCG	GGCTGCTGCCCGTGC
ACCTTGCTGCCCGGA	TTTGGTATGACGCGA	GCTGCTGCCCGTGCG
CCTTGCTGCCCGGAA	TTGGTATGACGCGAG	CTGCTGCCCGTGCGC
CTTGCTGCCCGGAAT	TGGTATGACGCGAGA	TGCTGCCCGTGCGCT
TTGCTGCCCGGAATT	GGTATGACGCGAGAT	GCTGCCCGTGCGCTG
TGCTGCCCGGAATTG	GTATGACGCGAGATA	CTGCCCGTGCGCTGG
GCTGCCCGGAATTGC	TATGACGCGAGATAT	TGCCCGTGCGCTGGA
CTGCCCGGAATTGCA	ATGACGCGAGATATC	GCCCGTGCGCTGGAT
TGCCCGGAATTGCAT	TGACGCGAGATATCT	CCCGTGCGCTGGATG
GCCCGGAATTGCATG	GACGCGAGATATCTA	CCGTGCGCTGGATGT
CCCGGAATTGCATGG	ACGCGAGATATCTAT	CGTGCGCTGGATGTC
CCGGAATTGCATGGT	CGCGAGATATCTATG	GTGCGCTGGATGTCT
CGGAATTGCATGGTA	GCGAGATATCTATGA	TGCGCTGGATGTCTC
GGAATTGCATGGTAG	CGAGATATCTATGAG	GCGCTGGATGTCTCC
GAATTGCATGGTAGC	GAGATATCTATGAGA	CGCTGGATGTCTCCT
AATTGCATGGTAGCC	AGATATCTATGAGAC	GCTGGATGTCTCCTG
ATTGCATGGTAGCCG	GATATCTATGAGACA	CTGGATGTCTCCTGA
TTGCATGGTAGCCGA	ATATCTATGAGACAG	TGGATGTCTCCTGAG
TGCATGGTAGCCGAA	TATCTATGAGACAGA	GGATGTCTCCTGAGT
GCATGGTAGCCGAAG	ATCTATGAGACAGAC	GATGTCTCCTGAGTC
CATGGTAGCCGAAGA	TCTATGAGACAGACT	ATGTCTCCTGAGTCC
ATGGTAGCCGAAGAT	CTATGAGACAGACTA	TGTCTCCTGAGTCCC
TGGTAGCCGAAGATT	TATGAGACAGACTAT	GTCTCCTGAGTCCCT
GGTAGCCGAAGATTT	ATGAGACAGACTATT	TCTCCTGAGTCCCTC
GTAGCCGAAGATTTC	TGAGACAGACTATTA	CTCCTGAGTCCCTCA
TAGCCGAAGATTTCA	GAGACAGACTATTAC	TCCTGAGTCCCTCAA
AGCCGAAGATTTCAC	AGACAGACTATTACC	CCTGAGTCCCTCAAG
GCCGAAGATTTCACA	GACAGACTATTACCG	CTGAGTCCCTCAAGG
CCGAAGATTTCACAG	ACAGACTATTACCGG	TGAGTCCCTCAAGGA
CGAAGATTTCACAGT	CAGACTATTACCGGA	GAGTCCCTCAAGGAT
GAAGATTTCACAGTC	AGACTATTACCGGAA	AGTCCCTCAAGGATG
AAGATTTCACAGTCA	GACTATTACCGGAAA	GTCCCTCAAGGATGG
AGATTTCACAGTCAA	ACTATTACCGGAAAG	TCCCTCAAGGATGGA
GATTTCACAGTCAAA	CTATTACCGGAAAGG	CCCTCAAGGATGGAG
ATTTCACAGTCAAAA	TATTACCGGAAAGGA	CCTCAAGGATGGAGT
TTTCACAGTCAAAAT	ATTACCGGAAAGGAG	CTCAAGGATGGAGTC
TTCACAGTCAAAATC	TTACCGGAAAGGAGG	TCAAGGATGGAGTCT
TCACAGTCAAAATCG	TACCGGAAAGGAGGC	CAAGGATGGAGTCTT
CACAGTCAAAATCGG	ACCGGAAAGGAGGCA	AAGGATGGAGTCTTC
ACAGTCAAAATCGGA	CCGGAAAGGAGGCAA	AGGATGGAGTCTTCA
CAGTCAAAATCGGAG	CGGAAAGGAGGCAAA	GGATGGAGTCTTCAC
AGTCAAAATCGGAGA	GGAAAGGAGGCAAAG	GATGGAGTCTTCACC
GTCAAAATCGGAGAT	GAAAGGAGGCAAAGG	ATGGAGTCTTCACCA
TCAAAATCGGAGATT	AAAGGAGGCAAAGGG	TGGAGTCTTCACCAC
CAAAATCGGAGATTT	AAGGAGGCAAAGGGC	GGAGTCTTCACCACT
AAAATCGGAGATTTT	AGGAGGCAAAGGGCT	GAGTCTTCACCACTT
AAATCGGAGATTTTG	GGAGGCAAAGGGCTG	AGTCTTCACCACTTA
AATCGGAGATTTTGG	GAGGCAAAGGGCTGC	GTCTTCACCACTTAC
ATCGGAGATTTTGGT	AGGCAAAGGGCTGCT	TCTTCACCACTTACT
TCGGAGATTTTGGTA	GGCAAAGGGCTGCTG	CTTCACCACTTACTC
TTCACCACTTACTCG	ACTGGCCGAGCAGCC	TGGAGGGCGGCCTTC
TCACCACTTACTCGG	CTGGCCGAGCAGCCC	GGAGGGCGGCCTTCT
CACCACTTACTCGGA	TGGCCGAGCAGCCCT	GAGGGCGGCCTTCTG
ACCACTTACTCGGAC	GGCCGAGCAGCCCTA	AGGGCGGCCTTCTGG
CCACTTACTCGGACG	GCCGAGCAGCCCTAC	GGGCGGCCTTCTGGA
CACTTACTCGGACGT	CCGAGCAGCCCTACC	GGCGGCCTTCTGGAC
ACTTACTCGGACGTC	CGAGCAGCCCTACCA	GCGGCCTTCTGGACA
CTTACTCGGACGTCT	GAGCAGCCCTACCAG	CGGCCTTCTGGACAA
TTACTCGGACGTCTG	AGCAGCCCTACCAGG	GGCCTTCTGGACAAG
TACTCGGACGTCTGG	GCAGCCCTACCAGGG	GCCTTCTGGACAAGC
ACTCGGACGTCTGGT	CAGCCCTACCAGGGC	CCTTCTGGACAAGCC
CTCGGACGTCTGGTC	AGCCCTACCAGGGCT	CTTCTGGACAAGCCA
TCGGACGTCTGGTCC	GCCCTACCAGGGCTT	TTCTGGACAAGCCAG
CGGACGTCTGGTCCT	CCCTACCAGGGCTTG	TCTGGACAAGCCAGA
GGACGTCTGGTCCTT	CCTACCAGGGCTTGT	CTGGACAAGCCAGAC
GACGTCTGGTCCTTC	CTACCAGGGCTTGTC	TGGACAAGCCAGACA
ACGTCTGGTCCTTCG	TACCAGGGCTTGTCC	GGACAAGCCAGACAA
CGTCTGGTCCTTCGG	ACCAGGGCTTGTCCA	GACAAGCCAGACAAC
GTCTGGTCCTTCGGG	CCAGGGCTTGTCCAA	ACAAGCCAGACAACT
TCTGGTCCTTCGCGG	CAGGGCTTGTCCAAC	CAAGCCAGACAACTG
CTGGTCCTTCGGGGT	AGGGCTTGTCCAACG	AAGCCAGACAACTGT
TGGTCCTTCGGGGTC	GGGCTTGTCCAACGA	AGCCAGACAACTGTC
GGTCCTTCGGGGTCG	GGCTTGTCCAACGAG	GCCAGACAACTGTCC
GTCCTTCGGGGTCGT	GCTTGTCCAACGAGC	CCAGACAACTGTCCT
TCCTTCGGGGTCGTC	CTTGTCCAACGAGCA	CAGACAACTGTCCTG
CCTTCGGGGTCGTCC	TTGTCCAACGAGCAA	ACACAACTGTCCTGA
CTTCGGGGTCGTCCT	TGTCCAACGAGCAAG	GACAACTGTCCTGAC
TTCGGGGTCGTCCTC	GTCCAACGAGCAAGT	ACAACTGTCCTGACA
TCGGGGTCGTCCTCT	TCCAACGAGCAAGTC	CAACTGTCCTGACAT
CGGGGTCGTCCTCTG	CCAACGAGCAAGTCC	AACTGTCCTGACATG
GGGGTCGTCCTCTGG	CAACGAGCAAGTCCT	ACTGTCCTGACATGC
GGGTCGTCCTCTGGG	AACGAGCAAGTCCTT	CTGTCCTGACATGCT
GGTCGTCCTCTGGGA	ACGAGCAAGTCCTTC	TGTCCTGACATGCTG
GTCGTCCTCTGGGAG	CGAGCAAGTCCTTCG	GTCCTGACATGCTGT
TCGTCCTCTGGGAGA	GAGCAAGTCCTTCGC	TCCTGACATGCTGTT
CGTCCTCTGGGAGAT	AGCAAGTCCTTCGCT	CCTGACATGCTGTTT
GTCCTCTGGGAGATC	GCAAGTCCTTCGCTT	CTGACATGCTGTTTG
TCCTCTGGGAGATCG	CAAGTCCTTCGCTTC	TGACATGCTGTTTGA
CCTCTGGGAGATCGC	AAGTCCTTCGCTTCG	GACATGCTGTTTGAA
CTCTGGGAGATCGCC	AGTCCTTCGCTTCGT	ACATGCTGTTTGAAC
TCTGGGAGATCGCCA	GTCCTTCGCTTCGTC	CATGCTGTTTGAACT
CTGGGAGATCGCCAC	TCCTTCGCTTCGTCA	ATGCTGTTTGAACTG
TGGGAGATCGCCACA	CCTTCGCTTCGTCAT	TGCTGTTTGAACTGA
GGGAGATCGCCACAC	CTTCGCTTCGTCATG	GCTGTTTGAACTGAT
GGAGATCGCCACACT	TTCGCTTCGTCATGG	CTGTTTGAACTGATG
GAGATCGCCACACTG	TCGCTTCGTCATGGA	TGTTTGAACTGATGC
AGATCGCCACACTGG	CGCTTCGTCATGGAG	GTTTGAACTGATGCG
GATCGCCACACTGGC	GCTTCGTCATGGAGG	TTTGAACTGATGCGC
ATCGCCACACTGGCC	CTTCGTCATGGAGGG	TTGAACTGATGCGCA
TCGCCACACTGGCCG	TTCGTCATGGAGGGC	TGAACTGATGCGCAT
CGCCACACTGGCCGA	TCGTCATGGAGGGCG	GAACTGATGCGCATG
GCCACACTGGCCGAG	CGTCATGGAGGGCGG	AACTGATGCGCATGT
CCACACTGGCCGAGC	GTCATGGAGGGCGGC	ACTGATGCGCATGTG
CACACTGGCCGAGCA	TCATGGAGGGCGGCC	CTGATGCGCATGTGC
ACACTGGCCGAGCAG	CATGGAGGGCGGCCT	TGATGCGCATGTGCT
CACTGGCCGAGCAGC	ATGGAGGGCGGCCTT	GATGCGCATGTGCTG
ATGCGCATGTGCTGG	CAGCAGCATCAAAGA	GCGAGGAGAACAAGC
TGCGCATGTGCTGGC	AGCAGCATCAAAGAG	CGAGGAGAACAAGCT
GCGCATGTGCTGGCA	GCAGCATCAAAGAGG	GAGGAGAACAAGCTG
CGCATGTGCTGGCAG	CAGCATCAAAGAGGA	AGGAGAACAAGCTGC
GCATGTGCTGGCAGT	AGCATCAAAGAGGAG	GGAGAACAAGCTGCC
CATGTGCTGGCAGTA	GCATCAAAGAGGAGA	GAGAACAAGCTGCCC
ATGTGCTGGCAGTAT	CATCAAAGAGGAGAT	AGAACAAGCTGCCCG
TGTGCTGGCAGTATA	ATCAAAGAGGAGATG	GAACAAGCTGCCCGA
GTGCTGGCAGTATAA	TCAAAGAGGAGATGG	AACAAGCTGCCCGAG
TGCTGGCAGTATAAC	CAAAGAGGAGATGGA	ACAAGCTGCCCGAGC
GCTGGCAGTATAACC	AAAGAGGAGATGGAG	CAAGCTGCCCGAGCC
CTGGCAGTATAACCC	AAGAGGAGATGGAGC	AAGCTGCCCGAGCCG
TGGCAGTATAACCCC	AGAGGAGATGGAGCC	AGCTGCCCGAGCCGG
GGCAGTATAACCCCA	GAGGAGATGGAGCCT	GCTGCCCGAGCCGGA
GCAGTATAACCCCAA	AGGAGATGGAGCCTG	CTGCCCGAGCCGGAG
CAGTATAACCCCAAG	GGAGATGGAGCCTGG	TGCCCGAGCCGGAGG
AGTATAACCCCAAGA	GAGATGGAGCCTGGC	GCCCGAGCCGGAGGA
GTATAACCCCAAGAT	AGATGGAGCCTGGCT	CCCGAGCCGGAGGAG
TATAACCCCAAGATG	GATGGAGCCTGGCTT	CCGAGCCGGAGGAGC
ATAACCCCAAGATGA	ATGGAGCCTGGCTTC	CGAGCCGGAGGAGCT
TAACCCCAAGATGAG	TGGAGCCTGGCTTCC	GAGCCGGAGGAGCTG
AACCCCAAGATGAGG	GGAGCCTGGCTTCCG	AGCCGGAGGAGCTGG
ACCCCAAGATGAGGC	GAGCCTGGCTTCCGG	GCCGGAGGAGCTGGA
CCCCAAGATGAGGCC	AGCCTGGCTTCCGGG	CCGGAGGAGCTGGAC
CCCAAGATGAGGCCT	GCCTGGCTTCCGGGA	CGGAGGAGCTGGACC
CCAAGATGAGGCCTT	CCTGGCTTCCGGGAG	GGAGGAGCTGGACCT
CAAGATGAGGCCTTC	CTGGCTTCCGGGAGG	GAGGAGCTGGACCTG
AAGATGAGGCCTTCC	TGGCTTCCGGGAGGT	AGGAGCTGGACCTGG
AGATGAGGCCTTCCT	GGCTTCCGGGAGGTC	GGAGCTGGACCTGGA
GATGAGGCCTTCCTT	GCTTCCGGGAGGTCT	GAGCTGGACCTGGAG
ATGAGGCCTTCCTTC	CTTCCGGGAGGTCTC	AGCTGGACCTGGAGC
TGAGGCCTTCCTTCC	TTCCGGGAGGTCTCC	GCTGGACCTGGAGCC
GAGGCCTTCCTTCCT	TCCGGGAGGTCTCCT	CTGGACCTGGAGCCA
AGGCCTTCCTTCCTG	CCGGGAGGTCTCCTT	TGGACCTGGAGCCAG
GGCCTTCCTTCCTGG	CGGGAGGTCTCCTTC	GGACCTGGAGCCAGA
GCCTTCCTTCCTGGA	GGGAGGTCTCCTTCT	GACCTGGAGCCAGAG
CCTTCCTTCCTGGAG	GGAGGTCTCCTTCTA	ACCTGGAGCCAGAGA
CTTCCTTCCTGGAGA	GAGGTCTCCTTCTAC	CCTGGAGCCAGAGAA
TTCCTTCCTGGAGAT	AGGTCTCCTTCTACT	CTGGAGCCAGAGAAC
TCCTTCCTGGAGATC	GGTCTCCTTCTACTA	TGGAGCCAGAGAACA
CCTTCCTGGAGATCA	GTCTCCTTCTACTAC	GGAGCCAGAGAACAT
CTTCCTGGAGATCAT	TCTCCTTCTACTACA	GAGCCAGAGAACATG
TTCCTGGAGATCATC	CTCCTTCTACTACAG	AGCCAGAGAACATGG
TCCTGGAGATCATCA	TCCTTCTACTACAGC	GCCAGAGAACATGGA
CCTGGAGATCATCAG	CCTTCTACTACAGCG	CCAGAGAACATGGAG
CTGGAGATCATCAGC	CTTCTACTACAGCGA	CAGAGAACATGGAGA
TGGAGATCATCAGCA	TTCTACTACAGCGAG	AGAGAACATGGAGAG
GGAGATCATCAGCAG	TCTACTACAGCGAGG	GAGAACATGGAGAGC
GAGATCATCAGCAGC	CTACTACAGCGAGGA	AGAACATGGAGAGCG
AGATCATCAGCAGCA	TACTACAGCGAGGAG	GAACATGGAGAGCGT
GATCATCAGCAGCAT	ACTACAGCGAGGAGA	AACATGGAGAGCGTC
ATCATCAGCAGCATC	CTACAGCGAGGAGAA	ACATGGAGAGCGTCC
TCATCAGCAGCATCA	TACAGCGAGGAGAAC	CATGGAGAGCGTCCC
CATCAGCAGCATCAA	ACAGCGAGGAGAACA	ATGGAGAGCGTCCCC
ATCAGCAGCATCAAA	CAGCGAGGAGAACAA	TGGAGAGCGTCCCCC
TCAGCAGCATCAAAG	AGCGAGGAGAACAAG	GGAGAGCGTCCCCCT
GAGAGCGTCCCCCTG	ACACTCAGGACACAA	CCAGCTTCGACGAGA
AGAGCGTCCCCCTGG	CACTCAGGACACAAG	CAGCTTCGACGAGAG
GAGCGTCCCCCTGGA	ACTCAGGACACAAGG	AGCTTCGACGAGAGA
AGCGTCCCCCTGGAC	CTCAGGACACAAGGC	GCTTCGACGAGAGAC
GCGTCCCCCTGGACC	TCAGGACACAAGGCC	CTTCGACGAGAGACA
CGTCCCCCTGGACCC	CAGGACACAAGGCCG	TTCGACGAGAGACAG
GTCCCCCTGGACCCC	AGGACACAAGGCCGA	TCGACGAGAGACAGC
TCCCCCTGGACCCCT	GGACACAAGGCCGAG	CGACGAGAGACAGCC
CCCCCTGGACCCCTC	GACACAAGGCCGAGA	GACGAGAGACAGCCT
CCCCTGGACCCCTCG	ACACAAGGCCGAGAA	ACGAGAGACAGCCTT
CCCTGGACCCCTCGG	CACAAGGCCGAGAAC	CGAGAGACAGCCTTA
CCTGGACCCCTCGGC	ACAAGGCCGAGAACG	GAGAGACAGCCTTAC
CTGGACCCCTCGGCC	CAAGGCCGAGAACGG	AGAGACAGCCTTACG
TGGACCCCTCGGCCT	AAGGCCGAGAACGGC	GAGACAGCCTTACGC
GGACCCCTCGGCCTC	AGGCCGAGAACGGCC	AGACAGCCTTACGCC
GACCCCTCGGCCTCC	GGCCGAGAACGGCCC	GACAGCCTTACGCCC
ACCCCTCGGCCTCCT	GCCGAGAACGGCCCC	ACAGCCTTACGCCCA
CCCCTCGGCCTCCTC	CCGAGAACGGCCCCG	CAGCCTTACGCCCAC
CCCTCGGCCTCCTCG	CGAGAACGGCCCCGG	AGCCTTACGCCCACA
CCTCGGCCTCCTCGT	GAGAACGGCCCCGGC	GCCTTACGCCCACAT
CTCGGCCTCCTCGTC	AGAACGGCCCCGGCC	CCTTACGCCCACATG
TCGGCCTCCTCGTCC	GAACGGCCCCGGCCC	CTTACGCCCACATGA
CGGCCTCCTCGTCCT	AACGGCCCCGGCCCT	TTACGCCCACATGAA
GGCCTCCTCGTCCTC	ACGGCCCCGGCCCTG	TACGCCCACATGAAC
GCCTCCTCGTCCTCC	CGGCCCCGGCCCTGG	ACGCCCACATGAACG
CCTCCTCGTCCTCCC	GGCCCCGGCCCTGGG	CGCCCACATGAACGG
CTCCTCGTCCTCCCT	GCCCCGGCCCTGGGG	GCCCACATGAACGGG
TCCTCGTCCTCCCTG	CCCCGGCCCTGGGGT	CCCACATGAACGGGG
CCTCGTCCTCCCTGC	CCCGGCCCTGGGGTG	CCACATGAACGGGGG
CTCGTCCTCCCTGCC	CCGGCCCTGGGGTGC	CACATGAACGGGGGC
TCGTCCTCCCTGCCA	CGGCCCTGGGGTGCT	ACATGAACGGGGGCC
CGTCCTCCCTGCCAC	GGCCCTGGGGTGCTG	CATGAACGGGGGCCG
GTCCTCCCTGCCACT	GCCCTGGGGTGCTGG	ATGAACGGGGGCCGC
TCCTCCCTGCCACTG	CCCTGGGGTGCTGGT	TGAACGGGGGCCGCA
CCTCCCTGCCACTGC	CCTGGGGTGCTGGTC	GAACGGGGGCCGCAA
CTCCCTGCCACTGCC	CTGGGGTGCTGGTCC	AACGGGGGCCGCAAG
TCCCTGCCACTGCCC	TGGGGTGCTGGTCCT	ACGGGGGCCGCAAGA
CCCTGCCACTGCCCG	GGGGTGCTGGTCCTC	CGGGGGCCGCAAGAA
CCTGCCACTGCCCGA	GGGTGCTGGTCCTCC	GGGGGCCGCAAGAAC
CTGCCACTGCCCGAC	GGTGCTGGTCCTCCG	GGGGCCGCAAGAACG
TGCCACTGCCCGACA	GTGCTGGTCCTCCGC	GGGCCGCAAGAACGA
GCCACTGCCCGACAG	TGCTGGTCCTCCGCG	GGCCGCAAGAACGAG
CCACTGCCCGACAGA	GCTGGTCCTCCGCGC	GCCGCAAGAACGAGC
CACTGCCCGACAGAC	CTGGTCCTCCGCGCC	CCGCAAGAACGAGCG
ACTGCCCGACAGACA	TGGTCCTCCGCGCCA	CGCAAGAACGAGCGG
CTGCCCGACAGACAC	GGTCCTCCGCGCCAG	GCAAGAACGAGCGGG
TGCCCGACAGACACT	GTCCTCCGCGCCAGC	CAAGAACGAGCGGGC
GCCCGACAGACACTC	TCCTCCGCGCCAGCT	AAGAACGAGCGGGCC
CCCGACAGACACTCA	CCTCCGCGCCAGCTT	AGAACGAGCGGGCCT
CCGACAGACACTCAG	CTCCGCGCCAGCTTC	GAACGAGCGGGCCTT
CGACAGACACTCAGG	TCCGCGCCAGCTTCG	AACGAGCGGGCCTTG
GACAGACACTCAGGA	CCGCGCCAGCTTCGA	ACGAGCGGGCCTTGC
ACAGACACTCAGGAC	CGCGCCAGCTTCGAC	CGAGCGGGCCTTGCC
CAGACACTCAGGACA	GCGCCAGCTTCGACG	GAGCGGGCCTTGCCG
AGACACTCAGGACAC	CGCCAGCTTCGACGA	AGCGGGCCTTGCCGC
GACACTCAGGACACA	GCCAGCTTCGACGAG	GCGGCCCTTGCCGCT
CGGGCCTTGCCGCTG	GCAAACAGTAACGTG	CAATCCATTCACAAG
GGGCCTTGCCGCTGC	CAAACAGTAACGTGT	AATCCATTCACAAGC
GGCCTTGCCGCTGCC	AAACAGTAACGTGTG	ATCCATTCACAAGCC
GCCTTGCCGCTGCCC	AACAGTAACGTGTGC	TCCATTCACAAGCCT
CCTTGCCGCTGCCCC	ACAGTAACGTGTGCG	CCATTCACAAGCCTC
CTTGCCGCTGCCCCA	CAGTAACGTGTGCGC	CATTCACAAGCCTCC
TTGCCGCTGCCCCAG	AGTAACGTGTGCGCA	ATTCACAAGCCTCCT
TGCCGCTGCCCCAGT	GTAACGTGTGCGCAC	TTCACAAGCCTCCTG
GCCGCTGCCCCAGTC	TAACGTGTGCGCACG	TCACAAGCCTCCTGT
CCGCTGCCCCAGTCT	AACGTGTGCGCACGC	CACAAGCCTCCTGTA
CGCTGCCCCAGTCTT	ACGTGTGCGCACGCG	ACAAGCCTCCTGTAC
GCTGCCCCAGTCTTC	CGTGTGCGCACGCGC	CAAGCCTCCTGTACC
CTGCCCCAGTCTTCG	GTGTGCGCACGCGCA	AAGCCTCCTGTACCT
TGCCCCAGTCTTCGA	TGTGCGCACGCGCAG	AGCCTCCTGTACCTC
GCCCCAGTCTTCGAC	GTGCGCACGCGCAGC	GCCTCCTGTACCTCA
CCCCAGTCTTCGACC	TGCGCACGCGCAGCG	CCTCCTGTACCTCAG
CCCAGTCTTCGACCT	GCGCACGCGCAGCGG	CTCCTGTACCTCAGT
CCAGTCTTCGACCTG	CGCACGCGCAGCGGG	TCCTGTACCTCAGTG
CAGTCTTCGACCTGC	GCACGCGCAGCGGGG	CCTGTACCTCAGTGG
AGTCTTCGACCTGCT	CACGCGCAGCGGGGT	CTGTACCTCAGTGGA
GTCTTCGACCTGCTG	ACGCGCAGCGGGGTG	TGTACCTCAGTGGAT
TCTTCGACCTGCTGA	CGCGCAGCGGGGTGG	GTACCTCAGTGGATC
CTTCGACCTGCTGAT	GCGCAGCGGGGTGGG	TACCTCAGTGGATCT
TTCGACCTGCTGATC	CGCAGCGGGGTGGGG	ACCTCAGTGGATCTT
TCGACCTGCTGATCC	GCAGCGGGGTGGGGG	CCTCAGTGGATCTTC
CGACCTGCTGATCCT	CAGCGGGGTGGGGGG	CTCAGTGGATCTTCA
GACCTGCTGATCCTT	AGCGGGGTGGGGGGG	TCAGTGGATCTTCAG
ACCTGCTGATCCTTG	GCGGGGTGGGGGGGG	CAGTGGATCTTCAGT
CCTGCTGATCCTTGG	CGGGGTGGGGGGGGA	AGTGGATCTTCAGTT
CTGCTGATCCTTGGA	GGGGTGGGGGGGGAG	GTGGATCTTCAGTTC
TGCTGATCCTTGGAT	GGGTGGGGGGGGAGA	TGGATCTTCAGTTCT
GCTGATCCTTGGATC	GGTGGGGGGGGAGAG	GGATCTTCAGTTCTG
CTGATCCTTGGATCC	GTGGGGGGGGAGAGA	GATCTTCAGTTCTGC
TGATCCTTGGATCCT	TGGGGGGGGAGAGAG	ATCTTCAGTTCTGCC
GATCCTTGGATCCTG	GGGGGGGGAGAGAGA	TCTTCAGTTCTGCCC
ATCCTTGGATCCTGA	GGGGGGGAGAGAGAG	CTTCAGTTCTGCCCT
TCCTTGGATCCTGAA	GGGGGGAGAGAGAGT	TTCAGTTCTGCCCTT
CCTTGGATCCTGAAT	GGGGGAGAGAGAGTT	TCAGTTCTGCCCTTG
CTTGGATCCTGAATC	GGGGAGAGAGAGTTT	CAGTTCTGCCCTTGC
TTGGATCCTGAATCT	GGGAGAGAGAGTTTT	AGTTCTGCCCTTGCT
TGGATCCTGAATCTG	GGAGAGAGAGTTTTA	GTTCTGCCCTTGCTG
GGATCCTGAATCTGT	GAGAGAGAGTTTTAA	TTCTGCCCTTGCTGC
GATCCTGAATCTGTG	AGAGAGAGTTTTAAC	TCTGCCCTTGCTGCC
ATCCTGAATCTGTGC	GAGAGAGTTTTAACA	CTGCCCTTGCTGCCC
TCCTGAATCTGTGCA	AGAGAGTTTTAACAA	TGCCCTTGCTGCCCG
CCTGAATCTGTGCAA	GAGAGTTTTAACAAT	GCCCTTGCTGCCCGC
CTGAATCTGTGCAAA	AGAGTTTTAACAATC	CCCTTGCTGCCCGCG
TGAATCTGTGCAAAC	GAGTTTTAACAATCC	CCTTGCTGCCCGCGG
GAATCTGTGCAAACA	AGTTTTAACAATCCA	CTTGCTGCCCGCGGG
AATCTGTGCAAACAG	GTTTTAACAATCCAT	TTGCTGCCCGCGGGA
ATCTGTGCAAACAGT	TTTTAACAATCCATT	TGCTGCCCGCGGGAG
TCTGTGCAAACAGTA	TTTAACAATCCATTC	GCTGCCCGCGGGAGA
CTGTGCAAACAGTAA	TTAACAATCCATTCA	CTGCCCGCGGGAGAC
TGTGCAAACAGTAAC	TAACAATCCATTCAC	TGCCCGCGGGAGACA
GTGCAAACAGTAACG	AACAATCCATTCACA	GCCCGCGGGAGACAG
TGCAAACAGTAACGT	ACAATCCATTCACAA	CCCGCGGGAGACAGC
CCGCGGGAGACAGCT	ATGCAAGCAGCTTTT	ACCTTAATGACAACA
CGCGGGAGACAGCTT	TGCAAGCAGCTTTTT	CCTTAATGACAACAC
GCGGGAGACAGCTTC	GCAAGCAGCTTTTTA	CTTAATGACAACACT
CGGGAGACAGCTTCT	CAAGCAGCTTTTTAT	TTAATGACAACACTT
GGGAGACAGCTTCTC	AAGCAGCTTTTTATT	TAATGACAACACTTA
GGAGACAGCTTCTCT	AGCAGCTTTTTATTC	AATGACAACACTTAA
GAGACAGCTTCTCTG	GCAGCTTTTTATTCC	ATGACAACACTTAAT
AGACAGCTTCTCTGC	CAGCTTTTTATTCCC	TGACAACACTTAATA
GACAGCTTCTCTGCA	AGCTTTTTATTCCCT	GACAACACTTAATAG
ACAGCTTCTCTGCAG	GCTTTTTATTCCCTG	ACAACACTTAATAGC
CAGCTTCTCTGCAGT	CTTTTTATTCCCTGC	CAACACTTAATAGCA
AGCTTCTCTGCAGTA	TTTTTATTCCCTGCC	AACACTTAATAGCAA
GCTTCTCTGCAGTAA	TTTTATTCCCTGCCC	ACACTTAATAGCAAC
CTTCTCTGCAGTAAA	TTTATTCCCTGCCCA	CACTTAATAGCAACA
TTCTCTGCAGTAAAA	TTATTCCCTGCCCAA	ACTTAATAGCAACAG
TCTCTGCAGTAAAAC	TATTCCCTGCCCAAA	CTTAATAGCAACAGA
CTCTGCAGTAAAACA	ATTCCCTGCCCAAAC	TTAATAGCAACAGAG
TCTGCAGTAAAACAC	TTCCCTGCCCAAACC	TAATAGCAACAGAGC
CTGCAGTAAAACACA	TCCCTGCCCAAACCC	AATAGCAACAGAGCA
TGCAGTAAAACACAT	CCCTGCCCAAACCCT	ATAGCAACAGAGCAC
GCAGTAAAACACATT	CCTGCCCAAACCCTT	TAGCAACAGAGCACT
CAGTAAAACACATTT	CTGCCCAAACCCTTA	AGCAACAGAGCACTT
AGTAAAACACATTTG	TGCCCAAACCCTTAA	GCAACAGAGCACTTG
GTAAAACACATTTGG	GCCCAAACCCTTAAC	CAACAGAGCACTTGA
TAAAACACATTTGGG	CCCAAACCCTTAACT	AACAGAGCACTTGAG
AAAACACATTTGGGA	CCAAACCCTTAACTG	ACAGAGCACTTGAGA
AAACACATTTGGGAT	CAAACCCTTAACTGA	CAGAGCACTTGAGAA
AACACATTTGGGATG	AAACCCTTAACTGAC	AGAGCACTTGAGAAC
ACACATTTGGGATGT	AACCCTTAACTGACA	GAGCACTTGAGAACC
CACATTTGGGATGTT	ACCCTTAACTGACAT	AGCACTTGAGAACCA
ACATTTGGGATGTTC	CCCTTAACTGACATG	GCACTTGAGAACCAG
CATTTGGGATGTTCC	CCTTAACTGACATGG	CACTTGAGAACCAGT
ATTTGGGATGTTCCT	CTTAACTGACATGGG	ACTTGAGAACCAGTC
TTTGGGATGTTCCTT	TTAACTGACATGGGC	CTTGAGAACCAGTCT
TTGGGATGTTCCTTT	TAACTGACATGGGCC	TTGAGAACCAGTCTC
TGGGATGTTCCTTTT	AACTGACATGGGCCT	TGAGAACCAGTCTCC
GGGATGTTCCTTTTT	ACTGACATGGGCCTT	GAGAACCAGTCTCCT
GGATGTTCCTTTTTT	CTGACATGGGCCTTT	AGAACCAGTCTCCTC
GATGTTCCTTTTTTC	TGACATGGGCCTTTA	GAACCAGTCTCCTCA
ATGTTCCTTTTTTCA	GACATGGGCCTTTAA	AACCAGTCTCCTCAC
TGTTCCTTTTTTCAA	ACATGGGCCTTTAAG	ACCAGTCTCCTCACT
GTTCCTTTTTTCAAT	CATGGGCCTTTAAGA	CCAGTCTCCTCACTC
TTCCTTTTTTCAATA	ATGGGCCTTTAAGAA	CAGTCTCCTCACTCT
TCCTTTTTTCAATAT	TGGGCCTTTAAGAAC	AGTCTCCTCACTCTG
CCTTTTTTCAATATG	GGGCCTTTAAGAACC	GTCTCCTCACTCTGT
CTTTTTTCAATATGC	GGCCTTTAAGAACCT	TCTCCTCACTCTGTC
TTTTTTCAATATGCA	GCCTTTAAGAACCTT	CTCCTCACTCTGTCC
TTTTTCAATATGCAA	CCTTTAAGAACCTTA	TCCTCACTCTGTCCC
TTTTCAATATGCAAG	CTTTAAGAACCTTAA	CCTCACTCTGTCCCT
TTTCAATATGCAAGC	TTTAAGAACCTTAAT	CTCACTCTGTCCCTG
TTCAATATGCAAGCA	TTAAGAACCTTAATG	TCACTCTGTCCCTGT
TCAATATGCAAGCAG	TAAGAACCTTAATGA	CACTCTGTCCCTGTC
CAATATGCAAGCAGC	AAGAACCTTAATGAC	ACTCTGTCCCTGTCC
AATATGCAAGCAGCT	AGAACCTTAATGACA	CTCTGTCCCTGTCCT
ATATGCAAGCAGCTT	GAACCTTAATGACAA	TCTGTCCCTGTCCTT
TATGCAAGCAGCTTT	AACCTTAATGACAAC	CTGTCCCTGTCCTTC
TGTCCCTGTCCTTCC	AATAATTGCCACAAG	GTCCCTGTGGCCCCA
GTCCCTGTCCTTCCC	ATAATTGCCACAAGT	TCCCTGTGGCCCCAT
TCCCTGTCCTTCCCT	TAATTGCCACAAGTC	CCCTGTGGCCCCATC
CCCTGTCCTTCCCTG	AATTGCCACAAGTCC	CCTGTGGCCCCATCC
CCTGTCCTTCCCTGT	ATTGCCACAAGTCCA	CTGTGGCCCCATCCA
CTGTCCTTCCCTGTT	TTGCCACAAGTCCAG	TGTGGCCCCATCCAA
TGTCCTTCCCTGTTC	TGCCACAAGTCCAGC	GTGGCCCCATCCAAC
GTCCTTCCCTGTTCT	GCCACAAGTCCAGCT	TGGCCCCATCCAACC
TCCTTCCCTGTTCTC	CCACAAGTCCAGCTG	GGCCCCATCCAACCA
CCTTCCCTGTTCTCC	CACAAGTCCAGCTGG	GCCCCATCCAACCAC
CTTCCCTGTTCTCCC	ACAAGTCCAGCTGGG	CCCCATCCAACCACT
TTCCCTGTTCTCCCT	CAAGTCCAGCTGGGA	CCCATCCAACCACTG
TCCCTGTTCTCCCTT	AAGTCCAGCTGGGAA	CCATCCAACCACTGT
CCCTGTTCTCCCTTT	AGTCCAGCTGGGAAG	CATCCAACCACTGTA
CCTGTTCTCCCTTTC	GTCCAGCTGGGAAGC	ATCCAACCACTGTAC
CTGTTCTCCCTTTCT	TCCAGCTGGGAAGCC	TCCAACCACTGTACA
TGTTCTCCCTTTCTC	CCAGCTGGGAAGCCC	CCAACCACTGTACAC
GTTCTCCCTTTCTCT	CAGCTGGGAAGCCCT	CAACCACTGTACACA
TTCTCCCTTTCTCTC	AGCTGGGAAGCCCTT	AACCACTGTACACAC
TCTCCCTTTCTCTCT	GCTGGGAAGCCCTTT	ACCACTGTACACACC
CTCCCTTTCTCTCTC	CTGGGAAGCCCTTTT	CCACTGTACACACCC
TCCCTTTCTCTCTCC	TGGGAAGCCCTTTTT	CACTGTACACACCCG
CCCTTTCTCTCTCCT	GGGAAGCCCTTTTTA	ACTGTACACACCCGC
CCTTTCTCTCTCCTC	GGAAGCCCTTTTTAT	CTGTACACACCCGCC
CTTTCTCTCTCCTCT	GAAGCCCTTTTTATC	TGTACACACCCGCCT
TTTCTCTCTCCTCTC	AAGCCCTTTTTATCA	GTACACACCCGCCTG
TTCTCTCTCCTCTCT	AGCCCTTTTTATCAG	TACACACCCGCCTGA
TCTCTCTCCTCTCTG	GCCCTTTTTATCAGT	ACACACCCGCCTGAC
CTCTCTCCTCTCTGC	CCCTTTTTATCAGTT	CACACCCGCCTGACA
TCTCTCCTCTCTGCT	CCTTTTTATCAGTTT	ACACCCGCCTGACAC
CTCTCCTCTCTGCTT	CTTTTTATCAGTTTG	CACCCGCCTGACACC
TCTCCTCTCTGCTTC	TTTTTATCAGTTTGA	ACCCGCCTGACACCG
CTCCTCTCTGCTTCA	TTTTATCAGTTTGAG	CCCGCCTGACACCGT
TCCTCTCTGCTTCAT	TTTATCAGTTTGAGG	CCGCCTGACACCGTG
CCTCTCTGCTTCATA	TTATCAGTTTGAGGA	CGCCTGACACCGTGG
CTCTCTGCTTCATAA	TATCAGTTTGAGGAA	GCCTGACACCGTGGG
TCTCTGCTTCATAAC	ATCAGTTTGAGGAAG	CCTGACACCGTGGGT
CTCTGCTTCATAACG	TCAGTTTGAGGAAGT	CTGACACCGTGGGTC
TCTGCTTCATAACGG	CAGTTTGAGGAAGTG	TGACACCGTGGGTCA
CTGCTTCATAACGGA	AGTTTGAGGAAGTGG	GACACCGTGGGTCAT
TGCTTCATAACGGAA	GTTTGAGGAAGTGGC	ACACCGTGGGTCATT
GCTTCATAACGGAAA	TTTGAGGAAGTGGCT	CACCGTGGGTCATTA
CTTCATAACGGAAAA	TTGAGGAAGTGGCTG	ACCGTGGGTCATTAC
TTCATAACGGAAAAA	TGAGGAAGTGGCTGT	CCGTGGGTCATTACA
TCATAACGGAAAAAT	GAGGAAGTGGCTGTC	CGTGGGTCATTACAA
CATAACGGAAAAATA	AGGAAGTGGCTGTCC	GTGGGTCATTACAAA
ATAACGGAAAAATAA	GGAAGTGGCTGTCCC	TGGGTCATTACAAAA
TAACGGAAAAATAAT	GAAGTGGCTGTCCCT	GGGTCATTACAAAAA
AACGGAAAAATAATT	AAGTGGCTGTCCCTG	GGTCATTACAAAAAA
ACGGAAAAATAATTG	AGTGGCTGTCCCTGT	GTCATTACAAAAAAA
CGGAAAAATAATTGC	GTGGCTGTCCCTGTG	TCATTACAAAAAAAC
GGAAAAATAATTGCC	TGGCTGTCCCTGTGG	CATTACAAAAAAACA
GAAAAATAATTGCCA	GGCTGTCCCTGTGGC	ATTACAAAAAAACAC
AAAAATAATTGCCAC	GCTGTCCCTGTGGCC	TTACAAAAAAACACG
AAAATAATTGCCACA	CTGTCCCTGTGGCCC	TACAAAAAAACACGT
AAATAATTGCCACAA	TGTCCCTGTGGCCCC	ACAAAAAAACACGTG
CAAAAAAACACGTGG	ATGAAATTTACAAAG	TAATTTTGCCAAAAT
AAAAAAACACGTGGA	TGAAATTTACAAAGG	AATTTTGCCAAAATC
AAAAAACACGTGGAG	GAAATTTACAAAGGG	ATTTTGCCAAAATCC
AAAAACACGTGGAGA	AAATTTACAAAGGGC	TTTTGCCAAAATCCT
AAAACACGTGGAGAT	AATTTACAAAGGGCC	TTTGCCAAAATCCTG
AAACACGTGGAGATG	ATTTACAAAGGGCCA	TTGCCAAAATCCTGA
AACACGTGGAGATGG	TTTACAAAGGGCCAT	TGCCAAAATCCTGAA
ACACGTGGAGATGGA	TTACAAAGGGCCATC	GCCAAAATCCTGAAC
CACGTGGAGATGGAA	TACAAAGGGCCATCG	CCAAAATCCTGAACT
ACGTGGAGATGGAAA	ACAAAGGGCCATCGT	CAAAATCCTGAACTT
CGTGGAGATGGAAAT	CAAAGGGCCATCGTT	AAAATCCTGAACTTT
GTGGAGATGGAAATT	AAAGGGCCATCGTTC	AAATCCTGAACTTTC
TGGAGATGGAAATTT	AAGGGCCATCGTTCA	AATCCTGAACTTTCT
GGAGATGGAAATTTT	AGGGCCATCGTTCAT	ATCCTGAACTTTCTC
GAGATGGAAATTTTT	GGGCCATCGTTCATC	TCCTGAACTTTCTCC
AGATGGAAATTTTTA	GGCCATCGTTCATCC	CCTGAACTTTCTCCC
GATGGAAATTTTTAC	GCCATCGTTCATCCA	CTGAACTTTCTCCCT
ATGGAAATTTTTACC	CCATCGTTCATCCAA	TGAACTTTCTCCCTC
TGGAAATTTTTACCT	CATCGTTCATCCAAG	GAACTTTCTCCCTCA
GGAAATTTTTACCTT	ATCGTTCATCCAAGG	AACTTTCTCCCTCAT
GAAATTTTTACCTTT	TCGTTCATCCAAGGC	ACTTTCTCCCTCATC
AAATTTTTACCTTTA	CGTTCATCCAAGGCT	CTTTCTCCCTCATCG
AATTTTTACCTTTAT	GTTCATCCAAGGCTG	TTTCTCCCTCATCGG
ATTTTTACCTTTATC	TTCATCCAAGGCTGT	TTCTCCCTCATCGGC
TTTTTACCTTTATCT	TCATCCAAGGCTGTT	TCTCCCTCATCGGCC
TTTTACCTTTATCTT	CATCCAAGGCTGTTA	CTCCCTCATCGGCCC
TTTACCTTTATCTTT	ATCCAAGGCTGTTAC	TCCCTCATCGGCCCG
TTACCTTTATCTTTC	TCCAAGGCTGTTACC	CCCTCATCGGCCCGG
TACCTTTATCTTTCA	CCAAGGCTGTTACCA	CCTCATCGGCCCGGC
ACCTTTATCTTTCAC	CAAGGCTGTTACCAT	CTCATCGGCCCGGCG
CCTTTATCTTTCACC	AAGGCTGTTACCATT	TCATCGGCCCGGCGC
CTTTATCTTTCACCT	AGGCTGTTACCATTT	CATCGGCCCGGCGCT
TTTATCTTTCACCTT	GGCTGTTACCATTTT	ATCGGCCCGGCGCTG
TTATCTTTCACCTTT	GCTGTTACCATTTTA	TCGGCCCGGCGCTGA
TATCTTTCACCTTTC	CTGTTACCATTTTAA	CGGCCCGGCGCTGAT
ATCTTTCACCTTTCT	TGTTACCATTTTAAC	GGCCCGGCGCTGATT
TCTTTCACCTTTCTA	GTTACCATTTTAACG	GCCCGGCGCTGATTC
CTTTCACCTTTCTAG	TTACCATTTTAACGC	CCCGGCGCTGATTCC
TTTCACCTTTCTAGG	TACCATTTTAACGCT	CCGGCGCTGATTCCT
TTCACCTTTCTAGGG	ACCATTTTAACGCTG	CGGCGCTGATTCCTC
TCACCTTTCTAGGGA	CCATTTTAACGCTGC	GGCGCTGATTCCTCG
CACCTTTCTAGGGAC	CATTTTAACGCTGCC	GCGCTGATTCCTCGT
ACCTTTCTAGGGACA	ATTTTAACGCTGCCT	CGCTGATTCCTCGTG
CCTTTCTAGGGACAT	TTTTAACGCTGCCTA	GCTGATTCCTCGTGT
CTTTCTAGGGACATG	TTTAACGCTGCCTAA	CTGATTCCTCGTGTC
TTTCTAGGGACATGA	TTAACGCTGCCTAAT	TGATTCCTCGTGTCC
TTCTAGGGACATGAA	TAACGCTGCCTAATT	GATTCCTCGTGTCCG
TCTAGGGACATGAAA	AACGCTGCCTAATTT	ATTCCTCGTGTCCGG
CTAGGGACATGAAAT	ACGCTGCCTAATTTT	TTCCTCGTGTCCGGA
TAGGGACATGAAATT	CCCTGCCTAATTTTG	TCCTCGTGTCCGGAG
AGGGACATGAAATTT	GCTGCCTAATTTTGC	CCTCGTGTCCGGAGG
GGGACATGAAATTTA	CTGCCTAATTTTGCC	CTCGTGTCCGGAGGC
GGACATGAAATTTAC	TGCCTAATTTTGCCA	TCGTGTCCGGAGGCA
GACATGAAATTTACA	GCCTAATTTTGCCAA	CGTGTCCGGAGGCAT
ACATGAAATTTACAA	CCTAATTTTGCCAAA	GTGTCCGGAGGCATG
CATGAAATTTACAAA	CTAATTTTGCCAAAA	TGTCCGGAGGCATGG
GTCCGGAGGCATGGG	CGACACACTCCGTCC	CAGGTCTCATTGCTT
TCCGGAGGCATGGGT	GACACACTCCGTCCA	AGGTCTCATTGCTTC
CCGGAGGCATGGGTG	ACACACTCCGTCCAT	GGTCTCATTGCTTCT
CGGAGGCATGGGTGA	CACACTCCGTCCATC	GTCTCATTGCTTCTG
GGAGGCATGGGTGAG	ACACTCCGTCCATCC	TCTCATTGCTTCTGA
GAGGCATGGGTGAGC	CACTCCGTCCATCCG	CTCATTGCTTCTGAC
AGGCATGGGTGAGCA	ACTCCGTCCATCCGA	TCATTGCTTCTGACT
GGCATGGGTGAGCAT	CTCCGTCCATCCGAC	CATTGCTTCTGACTA
GCATGGGTGAGCATG	TCCGTCCATCCGACT	ATTGCTTCTGACTAG
CATGGGTGAGCATGG	CCGTCCATCCGACTG	TTGCTTCTGACTAGA
ATGGGTGAGCATGGC	CGTCCATCCGACTGC	TGCTTCTGACTAGAT
TGGGTGAGCATGGCA	GTCCATCCGACTGCC	GCTTCTGACTAGATT
GGGTGAGCATGGCAG	TCCATCCGACTGCCC	CTTCTGACTAGATTA
GGTGAGCATGGCAGC	CCATCCGACTGCCCC	TTCTGACTAGATTAT
GTGAGCATGGCAGCT	CATCCGACTGCCCCT	TCTGACTAGATTATT
TGAGCATGGCAGCTG	ATCCGACTGCCCCTG	CTGACTAGATTATTA
GAGCATGGCAGCTGG	TCCGACTGCCCCTGC	TGACTAGATTATTAT
AGCATGGCAGCTGGT	CCGACTGCCCCTGCT	GACTAGATTATTATT
GCATGGCAGCTGGTT	CGACTGCCCCTGCTG	ACTAGATTATTATTT
CATGGCAGCTGGTTG	GACTGCCCCTGCTGT	CTAGATTATTATTTG
ATGGCAGCTGGTTGC	ACTGCCCCTGCTGTG	TAGATTATTATTTGG
TGGCAGCTGGTTGCT	CTGCCCCTGCTGTGC	AGATTATTATTTGGG
GGCAGCTGGTTGCTC	TGCCCCTGCTGTGCT	GATTATTATTTGGGG
GCAGCTGGTTGCTCC	GCCCCTGCTGTGCTG	ATTATTATTTGGGGG
CAGCTGGTTGCTCCA	CCCCTGCTGTGCTGC	TTATTATTTGGGGGA
AGCTGGTTGCTCCAT	CCCTGCTGTGCTGCT	TATTATTTGGGGGAA
GCTGGTTGCTCCATT	CCTGCTGTGCTGCTC	ATTATTTGGGGGAAC
CTGGTTGCTCCATTT	CTGCTGTGCTGCTCA	TTATTTGGGGGAACT
TGGTTGCTCCATTTG	TGCTGTGCTGCTCAA	TATTTGGGGGAACTG
GGTTGCTCCATTTGA	GCTGTGCTGCTCAAG	ATTTGGGGGAACTGG
GTTGCTCCATTTGAG	CTGTGCTGCTCAAGG	TTTGGGGGAACTGGA
TTGCTCCATTTGAGA	TGTGCTGCTCAAGGC	TTGGGGGAACTGGAC
TGCTCCATTTGAGAG	GTGCTGCTCAAGGCC	TGGGGGAACTGGACA
GCTCCATTTGAGAGA	TGCTGCTCAAGGCCA	GGGGGAACTGGACAC
CTCCATTTGAGAGAC	GCTGCTCAAGGCCAC	GGGGAACTGGACACA
TCCATTTGAGAGACA	CTGCTCAAGGCCACA	GGGAACTGGACACAA
CCATTTGAGAGACAC	TGCTCAAGGCCACAG	GGAACTGGACACAAT
CATTTGAGAGACACG	GCTCAAGGCCACAGG	GAACTGGACACAATA
ATTTGAGAGACACGC	CTCAAGGCCACAGGC	AACTGGACACAATAG
TTTGAGAGACACGCT	TCAAGGCCACAGGCA	ACTGGACACAATAGG
TTGAGAGACACGCTG	CAAGGCCACAGGCAC	CTGGACACAATAGGT
TGAGAGACACGCTGG	AAGGCCACAGGCACA	TGGACACAATAGGTC
GAGAGACACGCTGGC	AGGCCACAGGCACAC	GGACACAATAGGTCT
AGAGACACGCTGGCG	GGCCACAGGCACACA	GACACAATAGGTCTT
GAGACACGCTGGCGA	GCCACAGGCACACAG	ACACAATAGGTCTTT
AGACACGCTGGCGAC	CCACAGGCACACAGG	CACAATAGGTCTTTC
GACACGCTGGCGACA	CACAGGCACACAGGT	ACAATAGGTCTTTCT
ACACGCTGGCGACAC	ACAGGCACACAGGTC	CAATAGGTCTTTCTC
CACGCTGGCGACACA	CAGGCACACAGGTCT	AATAGGTCTTTCTCT
ACGCTGGCGACACAC	AGGCACACAGGTCTC	ATAGGTCTTTCTCTC
CGCTGGCGACACACT	GGCACACAGGTCTCA	TAGGTCTTTCTCTCA
GCTGGCGACACACTC	GCACACAGGTCTCAT	AGGTCTTTCTCTCAG
CTGGCGACACACTCC	CACACAGGTCTCATT	GGTCTTTCTCTCAGT
TGGCGACACACTCCG	ACACAGGTCTCATTG	GTCTTTCTCTCAGTG
GGCGACACACTCCGT	CACAGGTCTCATTGC	TCTTTCTCTCAGTGA
GCGACACACTCCGTC	ACAGGTCTCATTGCT	CTTTCTCTCAGTGAA
TTTCTCTCAGTGAAG
TTCTCTCAGTGAAGG
TCTCTCAGTGAAGGT
CTCTCAGTGAAGGTG
TCTCAGTGAAGGTGG
CTCAGTGAAGGTGGG
TCAGTGAAGGTGGGG
CAGTGAAGGTGGGGA
AGTGAAGGTGGGGAG
GTGAAGGTGGGGAGA
TGAAGGTGGGGAGAA
GAAGGTGGGGAGAAG
AAGGTGGGGAGAAGC
AGGTGGGGAGAAGCT
GGTGGGGAGAAGCTG
GTGGGGAGAAGCTGA
TGGGGAGAAGCTGAA
GGGGAGAAGCTGAAC
GGGAGAAGCTGAACC
GGAGAAGCTGAACCG
GAGAAGCTGAACCGG
AGAAGCTGAACCGGC

EXAMPLE 9

Inhibition of IGF-I Binding by Antisense Oligonucleotides to IGf-I Receptor

[0059] Sub-confluent HaCaT cells were treated as described above with phosphorothioate oligonucleotides IGFR.AS (antisense: 5′-ATCTCTCCGCTTCCTTT-3′; [SEQ ID NO. 10]; ref 13) and IGFR.S (sense control: 5′-GAAAGGAAGCGGAGAGAT-3′; [SEQ ID NO. 11]; Ref 13) IGF-I binding to the cell monolayers was then measured as 125I-IGF-I.

EXAMPLE 10

Inhibition of IGFBP-3 Production Using Antisense Oligonucleotides

[0060] The results of this experiment are shown in FIGS. 7 and 8.

[0061] HaCaT cells were initially plated in DMEM with 10% v/v serum, then AS oligo experiments were performed in complete “Keratinocyte-SFM” (Gibco) to exclude the influence of exogenous IGFBPs. Oligos were synthesised as phosphorothioate (nuclease-resistant) derivatives (Bresatec, South Australia) and were as follows: antisense: AS2, 5′-GCGCCCGCTGCATGACGCCTCAAC-3′ (IGFBP-3 start codon); control AS2NS, 5′-CGGAGATGCCGCATGCCAGCGCAGG-3′; AS4, 5′-AGGCGGCTGACGGCACTA-3′; AS4NS, 5′-GACAGCGTCGGAGCGATC-3′; IGFRAS, 5′-ATCTCTCCGCTTCCTTTC-3′; IGFRS, 5′-GAAAGGAAGCGGAGAGAT-3′. Oligos to IGFBP-3 were based on the published sequence of Spratt et al [12]. AS oligos were added to HaCaT monolayers in 0.5 ml medium in 24-well plates at the concentrations and addition frequencies indicated. IGFBP-3 measured in cell-conditioned medium using a dot-blot assay, adapted from the Western ligand blot method of Hossenlopp et al [11], in which 100 μl of conditioned medium was applied to nitrocellulose filters with a vacuum dot-blot apparatus. After drying the membranes at 37° C., relative amounts of IGFBP are determined by 125I-IGF-I-binding, autoradiography and computerised imaging densitometry. Triplicate wells (except in FIG. 7, where duplicate wells were measured as shown) were analysed and corrected for changes in cell number per well. Relative cell number per well was determined using an amido black dye method, developed specifically for cultured monolayers of HaCaT cells (14). Cell numbers differed by less than 10% after treatment. For oligos to the IGF receptor, receptor quantitation in intact HaCaT monolayers was by overnight incubation with 125I-IGF-I (30,000 cpm/well) at 4° C.

EXAMPLE11

Inhibition of IGFBP-2 Production Using Ribozymes

[0062] Experiments involving ribozymes are generally conducted as described in Internaitonal Patent Application No. WO 89/05852 and in Haselhoff and Gerlach [8]. Ribozymes are constructed with a hybridising region which is complementary in nucleotide sequence to at least part of a target RNA which, in this case, encodes IGFBP-2. Activity of ribozymes is measurable on, for example, Northern blots or using animal models such as in the nude mouse model (15; 16) or the “flaky skin” mouse model (17; 18).

EXAMPLE 12

Inhibition of IGFBP-3 Production Using Ribozymes

[0063] The methods described in Example 11 are used for the screening of ribozymes which inhibit IGFBP-3 production. The activity of the ribozymes is determined as in Example 11.

EXAMPLE 13

Inhibition of IGF-1 Production Using Ribozymes

[0064] The methods described in Example 11 are used for the screening of ribozymes which inhibit IGF-1 production. The activity of the ribozymes is determined as in Example 11.

EXAMPLE 14

Inhibition of IGF-1 Receptor Production Using Ribozymes

[0065] The methods described in Example 11 are used for the screening of ribozymes which inhibit IGF-1 production. The activity of the ribozymes is determined as in Example 11

[0066] Those skilled in the art will appreciate that the invention described herein is susceptible to variations and modifications other than those specifically described. It is to be understood that the invention includes all such variations and modifications. The invention also includes all of the steps, features, compositions and compounds referred to or indicated in this specification, individually or collectively, and any and all combinations of any two or more of said steps or features.

[0067] References:

[0068] 1. Sara V Physiological Reviews 70: 591-614, 1990.

[0069] 2. Rechler M M and Brown A L Growth Regulation 2: 55-68, 1992.

[0070] 3. Clemmons D R Growth Regn 2: 80, 1992.

[0071] 4. Oakes S R, K M Haynes, M J Waters, A C Herington and G A Werther J. Clin Endocrinol Metab 73: 1368-1373, 1992.

[0072] 5. Camacho-Hubner C et al. J Biol Chem 267: 11949-11956, 1992.

[0073] 6. Neely K E et al. J Inv Derm 96: 104, 1991.

[0074] 7. Ts'O POP; Aurelian L, Chang E and Miller P S. Nonionic oligonucleotide analogs (Matagen TM) as anticodic agents in duplex and triplex formation. in “Antisense Strategies”, Annals of the New York Academy of Sciences 660:159-177 (Baserga R and Denhardt D T, eds.), 1993.

[0075] 8. Haseloff J and Gerlach L Nature 334: 586-591, 1988.

[0076] 9. Boukamp P, Petrussevska R T, Breitkreuz D, Hornung J, Markham A, Fusenig N E. J Cell Biol 106: 761-771, 1988.

[0077] 10. Rheinwald and Green Cell 6: 331-344, 1975.

[0078] 11. Hossenlopp P, Seurin D, Segovia-Quinson B, Hardouin S, Binoux M. Anal Biochem 154: 138-143, 1986.

[0079] 12. Spratt S K, Tatsuno G P, Yamanaka M K, Ark B C, Detmer J, Mascarenhas D, Flynn J, Talkington-Verser C, Spencer E M. Growth Factors 3: 63-72, 1990.

[0080] 13. Pietrzkowski, Z, Sell C, Lammers R, Ullrich A and Baserga R. Mol. Cell. Biol. 12: 3883-3889, 1992.

[0081] 14. Schulz J, Dettlaff S, Fritzsche U, Harms U, Schiebel H, Derer W, Fusenig N E, Hulsen A and Bohm M. J. Immunol Meth. 167: 1-13, 1994.

[0082] 15. Baker B S, Brent L, Valdimarsson H, Powles A V, Al-Imara L, Walker M and Fry L. Brit. J Bermatol 126: 105-110, 1992.

[0083] 16. Nanney L B et al J Invest. Bermatol 98: 296-301, 1992.

[0084] 17. Sundberg J P et al Immunol. Investigations 22: 389401, 1993.

[0085] 18. Sundberg J P et al J Invest. Dermatol 102: 781-788, 1994.

Claims

1. A method for ameliorating the effects of a proliferative and/or inflammatory skin disorder in a mammal, said method comprising contacting the proliferating and/or inflamed skin or skin capable of proliferation and/or inflammation with an effective amount of a nucleic acid molecule or chemical analogue thereof capable of inhibiting or otherwise reducing growth factor mediated cell proliferation and/or inflammation.

2. A method according to claim 1 wherein cell proliferation and/or inflammation is mediated by at least one of insulin-like growth factor I (IGF-I ), keratinocyte growth factor (KGF), transforming growth factor-α (TGFα), tumour necrosis factor-α (TNFα), interleukin (IL)-1 (IL-1), IL-4, IL-6, IL-8 and/or basic fibroblast growth factor (bFGF).

3. A method according to claim 2 wherein cell proliferation and/or inflammation is mediated by IGF-I.

4. A method according to claim 1 wherein the nucleic acid molecule inhibits or otherwise reduces IGF-I mediated cell proliferation and/or inflammation.

5. A method according to claim 1 wherein the proliferative or inflammatory skin disorder is psoriasis, ichthyosis, pityriasis, rubra, pilaris, serborrhoea, keloids, keratosis, neoplasias, scleroderma, warts, benign growths or cancers of the skin.

6. A method according to claim 5 wherein the skin condition is psoriasis.

7. A method according to claim 1 or 4 or 6 wherein the mammal is a human.

8. A method according to claim 1 or 4 or 6 wherein the nucleic acid molecule is capable of inhibiting, reducing or otherwise interfering with IGF-I-interaction with its receptor.

9. A method according to claim 8 wherein the nucleic acid molecule is an antisense molecule capable of reducing expression of a gene encoding IGF-I, IGF-I-receptor or an IGF binding protein (IGFBP).

10. A method according to claim 9 wherein the nucleic acid molecule is an antisense molecule capable of reducing expression of a gene encoding IGFBP-2, -3, -4, -5 or -6.

11. A method according to claim 10 wherein the nucleic acid molecule is an antisense molecule capable of reducing expression of a gene encoding IGFBP-2 or IGFBP-3.

12. A method according to claim 11 wherein the antisense molecule is at least about 15 nucleotides in length and is capable of interacting with at least one sequence selected from the list set forth in Example 6 or Example 7.

13. A method according to claim 11 wherein the antisense molecule comprises the nucleotide sequence:

14. A nucleic acid molecule comprising at least about 10 nucleotides capable of hybridising to or forming a heteroduplex or otherwise interacting with an RNA molecule directed from a gene corresponding to a genomic form of SEQ ID NO: 1 and/or SEQ ID NO: 2 and which thereby reduces or inhibits translation of said RNA molecule.

15. A nucleic acid molecule according to claim 14 wherein said molecule comprises at least about 15 nucleotides.

16. A nucleic acid molecule according to claim 15 wherein said molecule is capable of interacting with at least one nucleotide sequence selected from the list set forth in Example 6 and Example 7.

17. A nucleic acid molecule according to claim 15 or 16 comprising the nucleotide sequence:

18. A method of ameliorating the effects of psoriasis, said method comprising contacting proliferating skin or skin capable of proliferation with an effective amount of one or more nucleic acid molecules or chemical analogues thereof capable of inhibiting or otherwise reducing IGF-I mediated cell proliferation wherein said one or more molecules comprises a polynucleotide capable of interacting with mRNA directed from an IGF-I gene, an IGF-I receptor gene or a gene encoding an IGFBP.

19. A method according to claim 18 wherein the IGFBP is IGFBP-2 or IGFBP-3.

20. A method according to claim 18 or 19 wherein the mammal is a human.

21. A method according to claim 20 wherein the nucleic acid molecule is capable of interacting with a nucleotide sequence selected from the list set forth in Example 6 or Example 7.

22. A method according to claim 18 wherein the nucleic acid molecule comprises the nucleotide sequence:

23. A pharmaceutical composition for topical administration said composition comprising a nucleic acid molecule capable of inhibiting or otherwise reducing IGF-I mediated cell proliferation said composition further comprising one or more pharmaceutically acceptable carriers and/or diluents.

24. A pharmaceutical composition according to claim 23 wherein the nucleic acid molecule is an antisense molecule to a gene encoding IGF-I, IGF-I-receptor or an IGFBP.

25. A pharmaceutical composition according to claim 24 wherein the nucleic acid molecule is capable of targeting a gene encoding IGFBP-2 and/or IGFBP-3.

26. A pharmaceutical composition according to claim 24 capable of interacting with at least one nucleotide sequence set forth in Example 6 or Example 7.

27. Use of a nucleic acid molecule in the manufacture of a medicament for the treatment of a proliferative and/or inflammatory skin disorder mediated by IGF-I.

28. Use according to claim 27 wherein the skin disorder is psoriasis.

29. A ribozyme comprising a hybridising region and a catalytic region wherein the hybridising region is capable of hybridising to at least part of a target mRNA sequence transcribed from a genomic gene corresponding to SEQ ID NO: 1or SEQ ID NO: 2 wherein said catalytic domain is capable of cleaving said target mRNA sequence to reduce or inhibit IGF-I mediated cell proliferation or inflammation.