Claims
- 1. A method for the reduction of an oxygenated compound of rhenium or technetium with a reducing agent, wherein the reduction reaction is carried out in the presence of a macromolecular compound selected from the group consisting of cyclic oligosaccharides, crown ethers, and cryptands, wherein said macromolecular compound is effective to displace the equilibrium of the reduction reaction toward the formation of a reduced species of said oxygenated compound and the reducing agent is selected from the group consisting of Sn.sup.2+, Fe.sup.2+, and Cu.sup.1+ ions, and wherein the reducing agent is introduced into the reaction medium in the form of a halide, a phosphonate, or a salt of a polycarboxylic acid.
- 2. A method for the reduction of an oxygenated compound of rhenium or technetium with a reducing agent, wherein the reduction reaction is carried out in the presence of a macromolecular compound selected from the group consisting of crown ethers and cryptands, wherein said macromolecular compound is effective to displace the equilibrium of the reduction reaction toward the formation of a reduced species of said oxygenated compound.
- 3. The method according to claim 2 wherein the reduction is carried out in the presence of a ligand which can form a complex with the reduced species of the oxygenated compound of rhenium or technetium.
- 4. The method according to claim 2, in which the oxygenated compound is perrhenate ion or pertechnetate ion.
- 5. The method according to claim 2 wherein the reduction reaction is carried out in the presence of a secondary reducing agent comprising a polycarboxylic acid or metal salt thereof.
- 6. The method according to claim 2, in which the reducing agent is selected from the ions Sn.sup.2+, Fe.sup.2+, and Cu.sup.1+.
- 7. The method according to claim 1, in which the polycarboxylic acid salt is selected from the group consisting of tarrates, citrates, oxalates, gluconates, and glucoheptonates.
- 8. The method according to claim 2, in which the reducing agent is selected from the group consisting of phosphines, alkali metal thiosulphites, dithionites, alkali metal dithionites, and alkali metal borohydride.
- 9. The method according to claim 3, in which the ligand is selected from the group consisting of phosphines, arsines, thiols, thioethers, isonitriles, amines, cyclic amines, polyamines, dithiocarbamates, dithiocarboxylates, Schiff bases, diaminodithiols, bis(amino)thiols, oximes, sugars, borates, amino acids, polyamino acids, peptides, peptides modified with phosphine groups and ligands, and mixtures thereof.
- 10. The method according to claim 9, in which the reduction reaction is carried out in the presence of a first ligand able to promote the stabilisation of the reduced state of the metal to form a complex which can undergo substitution reactions with other ligands, and in the presence of a second ligand which can undergo said substitution reaction with the first ligand to form a stable complex of the second ligand.
- 11. A method for the reduction of an oxygenated compound of rhenium or technetium with a reducing agent, characterised in that the reduction reaction is carried out in the presence of a macromolecular compound selected from the group consisting of cyclic oligosaccharides, crown ethers, and cryptands, wherein said macromolecular compound is effective to displace the equilibrium of the reduction reaction toward the formation of a reduced species of said oxygenated compound, and wherein the reduction reaction is carried out in the presence of a first ligand able to promote stabilisation of the reduced state of the metal to form a complex which can undergo a substitution reaction with other ligands, and in the presence of a second ligand which can undergo said substitution reaction with the first ligand to form a stable complex of the second ligand, said first ligand being a polycarboxylate compound.
- 12. The method according to claim 11, wherein the polycarboxylate compound comprises an oxalate or a citrate.
- 13. The method according to claim 2, wherein the reduction reaction is carried out at a pH of from 5 to 8.
- 14. A method of reducing a reaction time in a reaction for a reduction of perrhenate ion or pertechnetate ion in the presence of a reducing agent comprising using a macromolecular compound selected from the group consisting of crown ethers and cryptands.
- 15. A method for the reduction of an oxygenated compound of rhenium or technetium with a reducing agent, characterised in that the reduction reaction is carried out in the presence of a macromolecular compound selected from the group consisting of cyclic oligosaccharides, crown ethers, and cryptands, wherein said macromolecular compound is effective to displace the equilibrium of the reduction reaction toward the formation of a reduced species of said oxygenated compound, and wherein the reduction is carried out in the presence of a ligand selected from the group consisting of dimercaptosuccinic acid, 3,6-diaza-1,8-octanedithiol, 3,7-diaza-1,9-nonanedithiol, and tris(2-sulphonatophenyl)phosphine sodium salt.
Priority Claims (1)
Number |
Date |
Country |
Kind |
T96A0805 |
Oct 1996 |
ITX |
|
Parent Case Info
This application is a 371 of PCT/EP97/05448 filed Oct. 3, 1997.
PCT Information
Filing Document |
Filing Date |
Country |
Kind |
102e Date |
371c Date |
PCT/EP97/05448 |
10/3/1997 |
|
|
6/4/1999 |
6/4/1999 |
Publishing Document |
Publishing Date |
Country |
Kind |
WO98/14219 |
4/9/1998 |
|
|
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
5300280 |
Derosch et al. |
Apr 1994 |
|
Foreign Referenced Citations (1)
Number |
Date |
Country |
0 311 891 |
Apr 1989 |
EPX |