Claims
- 1. A method for the treatment of diseases which are due to defects in the immune system in mammals, which comprises administering to a mammal in need of such treatment an effective amount of a salt of an organic base and N,N'-diacetylcystine having the formula ##STR2## or a hydrate or a solvate thereof wherein the organic base, R.sup.30 or R.sup.2+, is selected from the group consisting of lysinium, ethylenediaminium N,N'-dibenzylethylenediaminium, N-benzy2-phenylethylaminium and 1-adamantanaminium and wherein the disease is selected from the group consisting of chronic bronchitis, rheumatoid arthritis, hepatitis, asthma, rhinitis, atherosclerosis, HIV infection and AIDS.
- 2. The method according to claim 1 wherein the effective amount of the salt is administered in solid form as a dried powder from a pressurized meter dose inhaler.
- 3. The method according to claim 1 wherein the salt is crystallized.
Priority Claims (1)
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9103572 |
Nov 1991 |
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Parent Case Info
This application is a divisional of application Ser. No. 08/335,941, filed on Nov. 8. 1994, now U.S. Pat. No. 5,693,858, which is a continuation of application Ser. No. 07/981,375, filed Nov. 25, 1992, issued as U.S. Pat. No. 5.383,904 on Jan. 31, 1995.
US Referenced Citations (11)
Foreign Referenced Citations (6)
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0300100 |
Jan 1989 |
EPX |
2503151 |
Apr 1981 |
FRX |
155298 |
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JPX |
62-195356 |
Aug 1987 |
JPX |
9118594 |
Dec 1991 |
WOX |
921362 |
Dec 1992 |
WOX |
Non-Patent Literature Citations (2)
Entry |
Marshall, et al. "Preparation and Properties of the Isomeric Forms of Crystine and S-Benzylpenicillamine," J. Amer. Chem. Soc. 79: 4538-4544, 1957. |
Greenstein, et al. "Ammonia Formation from Cystine Peptides and Dehydropeptides in Rat Liver Digests," Arch. of Biochem. 18: 377-82, 1948. |
Continuations (2)
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335941 |
Nov 1994 |
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Parent |
981373 |
Nov 1992 |
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