Claims
- 1. A method for antagonizing LHRH in a mammal which comprises administering to a mammal in need thereof an effective amount of a pharmaceutical composition comprising a pharmaceutically acceptable diluent or carrier in association with a benzodiazepine of the following formula (I): ##STR10## wherein R.sup.1 is an amine function of the formula ##STR11## R.sup.2 is hydrogen, alkoxy having 1-6 carbons, alkyl having 1-6 carbons, trifluoromethyl, halogen, nitro, hydroxy or dialkylamino having 2-10 carbons;
- R.sup.6 is hydrogen, alkyl having 1-8 carbons, carboxy, alkoxycarbonyl wherein the alkoxy group has 1-6 carbons or phenyl; and
- R.sup.7 is hydrogen, alkyl having 1-8 carbons, alkoxycarbonyl wherein the alkoxy group has 1-6 carbons or alkyl having 1-8 carbons substituted by hydroxy, halogen, alkoxy having 1-6 carbons, phenoxy or alkoxycarbonyl wherein the alkoxy group has 1-6 carbons;
- and the pharmaceutically acceptable salts thereof.
- 2. The method of claim 1, wherein said benzodiazepine is selected from the group consisting of:
- 12-(4-methyl-1-piperazinyl)-6H-indolo[2,1-c][1,4]-benzodiazepine;
- 4-(6H-indolo[2,1-c][1,4]benzodiazepine-12-yl)piperazine-1-propanol;
- 12-(1-piperazinyl)-6H-indolo[2,1-c][1,4]-benzodiazepine;
- 12-(4-(ethoxycarbonyl)-1-piperazinyl)-6H-indolo[2,1-c][1,4]benzodiazepine; and
- 12-(4-n-butyl-1-piperazinyl)-6H-indolo[2,1-c][1,4]benzodiazepine.
- 3. The method of claim 2, wherein said benzodiazepine is 12-(4-methyl-1-piperazinyl)-6H-indolo[2,1-c][1,4]benzodiazepine.
- 4. The method of claim 1, wherein said method is for treating precocious puberty.
- 5. The method of claim 1, wherein said method is for treating endometriosis.
Parent Case Info
This is a continuation-in-part of application Ser. No. 599,095, now U.S. Pat. No. 4,547,497 filed Apr. 11, 1984 and Ser. No. 721,723 now U.S. Pat. No. 4,587,244 filed Apr. 10, 1985.
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
599095 |
Apr 1984 |
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