Claims
- 1. A method of treating an acute attack of asthma, while reducing side effects associated with the acute administration of racemic albuterol, comprising administering to an individual suffering from an acute attack of asthma a quantity of an optically pure R(-) isomer of albuterol sufficient to result in bronchodilation while simultaneously reducing undesirable side effects, said R isomer being substantially free of its S(+) isomer.
- 2. A method of claim 1 wherein the amount of the R(-) isomer of albuterol is greater than approximately 90% by weight.
- 3. A method of claim 2 wherein the amount of the R(-) isomer of albuterol is greater than 99% by weight.
- 4. A method of claim 1 comprising administering to the individual by inhalation from approximately 30 mcg to approximately 90 mcg of the R(-) isomer of albuterol per dose.
- 5. A method of treating an acute attack of asthma, while reducing side effects associated with the acute administration of racemic albuterol, comprising administering to an individual suffering from an acute attack of asthma a quantity of an optically pure R(-) isomer of albuterol sufficient to result in bronchodilation while simultaneously reducing undesirable side effects, and at least one additional drug selected from the group consisting of bronchodilators, antihistamines and analgesics.
- 6. A method of claim 5 wherein the analgesic is selected from the group consisting of: aspirin, acetaminophen and ibuprofen.
CROSS REFERENCE TO RELATED APPLICATIONS
This application is a continuation of application Ser. No. 08/163,581, filed Dec. 7, 1993 and now U.S. Pat. No. 5,362,755, which was a continuation of application Ser. No. 07/896,725, filed Jun. 9, 1992, now abandoned, which was a continuation of application Ser. No. 07/461,262 filed Jan. 5, 1990, now abandoned.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
5362755 |
Barberich et al. |
Nov 1994 |
|
Foreign Referenced Citations (1)
Number |
Date |
Country |
2255503 |
Jul 1992 |
GBX |
Non-Patent Literature Citations (11)
Entry |
Tan et al. "Stereoselective Disposition of Salbutamol Enantiomers . . . " Clin. Chem. 33, 1026 (1987). |
Brittain et al. "Some observations on the .beta.-adrenoceptor agonist . . . " Br. J. Pharmac. 48, 144-147 (1973). |
Hartley et al. "Absolute Configuration of the Optical Isomers of Salbutamol" J. Med. Chem. 12, 995 (1971). |
Hawkins et al. "Relative Potency of (-)-and (.+-.)-Salbutamol on Guinea Pig . . . " J. Med. Chem. 16, 856.varies.857 (1973). |
Buckner et al. "Studies on the Effects of Enantiomers of Soterenol, Trimetoquinol . . . " J. Pharm. Exp. Ther. 189, 616-625 (1974). |
Passowicz-Muszynska E. "Effect on beta adrenergic receptors of tachyphylaxis . . . " Index Medicus 91:164287 (1990). |
Pauwels "Effect of corticosteroids on the action of sympathomimetics" Index Medicus 86:051970 (1985). |
Chapman et al. "An anomalous effect of salbutamol in sensitised guinea pigs" Brit. J. Pharmacol 99, 66P (1990). |
Morley et al. "Effects of (+) and racemic salbutamol on airway responses in the guinea pig" Brit. J. Pharmacol. 104, 295P (1991). |
Chapman et al. "Racemic mixtures at root of worsening symptoms? Active enantiomers . . . " Tips 13, 231-232 (1992). |
Muittari et al. "Comparison of acute bronchodilator effects of oral salbutamol, . . . " Chem. Abstr. 89: 123259m (1978). |
Continuations (3)
|
Number |
Date |
Country |
Parent |
163581 |
Dec 1993 |
|
Parent |
896725 |
Jun 1992 |
|
Parent |
461262 |
Jan 1990 |
|