Claims
- 1. A method of treating depression in a mammal identified as being in need of such treatment, comprising administration to said mammal of an effective depression treatment amount of a compound of formula (I) ##STR6## n is 0, 1 or 2; one of R.sup.1 and R.sup.2 is hydrogen and the other is selected from carbamoyl, N-C.sub.1-4 alkylcarbamoyl, N,N-di-C.sub.1-4 alkylcarbamoyl, carbamimidoyl, N.sup.1 -C.sub.1-4 alkylcarbamimidoyl, N.sup.2 -C.sub.1-4 alkylcarbamimidoyl, N.sup.1 -C.sub.1-4 alkyl-N.sup.2 -C.sub.1-4 alkylcarbamimidoyl, N.sup.1,N.sup.1 -di-C.sub.1-4 alkylcarbamimidoyl, N.sup.1,N.sup.1 -di-C.sub.1-4 alkyl-N.sup.2 -C.sub.1-4 alkylcarbimidoyl, and imidazolin-2-yl (optionally substituted by one or more C.sub.1-4 alkyl groups); and
- R.sup.3 is selected from hydrogen, saturated and unsaturated aliphatic hydrocarbon moieties containing from 1 to 4 carbon atoms, groups OR.sup.4 (where R.sup.4 is selected from hydrogen and saturated and unsaturated aliphatic hydrocarbon moieties containing from 1 to 4 carbon atoms), halo, groups of formula --NR.sup.5 R.sup.6 (where R.sup.5 and R.sup.6 are independently selected from hydrogen, C.sub.1-4 alkyl and hydroxy C.sub.1-4 alkyl, provided that the total number of carbon atoms in R.sup.5 and R.sup.6 does not exceed 4), amino-C.sub.1-4 alkylamino and morpholino; provided that when n is 2 and R.sup.2 is hydrogen, then R.sup.1 is not carbamoyl when R.sup.3 is hydrogen or methyl; and R.sup.1 is not N-methylcarbamoyl when R.sup.3 is hydrogen; or a physiologically acceptable salt thereof.
- 2. The method of claim 1 in which the compound 3-carboxythioxanthen-9-one 10,10-dioxide or a physiologically acceptable salt thereof is administered.
Priority Claims (1)
Number |
Date |
Country |
Kind |
8400203 |
May 1984 |
GBX |
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Parent Case Info
This application is a division of application Ser. No. 688,747, filed Jan. 4, 1985, now abandoned.
US Referenced Citations (3)
Number |
Name |
Date |
Kind |
3310553 |
Bloom et al. |
Mar 1967 |
|
3642997 |
Shen et al. |
Feb 1972 |
|
4177257 |
Hodson et al. |
Dec 1979 |
|
Foreign Referenced Citations (1)
Number |
Date |
Country |
1458185 |
Dec 1976 |
GBX |
Non-Patent Literature Citations (1)
Entry |
Sheehan, J. Psychiatry, 45, 1984, pp. 29-36. |
Divisions (1)
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Number |
Date |
Country |
Parent |
688747 |
Jan 1985 |
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