Claims
- 1. A method of treating depression, an obsessive compulsive disorder or anxiety in a human in need thereof which comprises administering an effective amount of melatonin receptors (MT-3) agonists: 5-methoxy-carbonylamino-N-acetyltryptamine (5-MCA-NAT) or analogs thereof, the analogs having the following formula I:
- 2. The method of claim 1, wherein said MT-3 agonists are administered by the oral route.
- 3. The method of claim 1, wherein said MT-3 agonists are administered together with an acceptable carrier therefor.
- 4. The method of claim 1, wherein said MT-3 agonists are administered in the form of an orally ingestible capsule or tablet.
- 5. The method of claim 1, wherein said MT-3 agonists are administered in combination with a Ca++ antagonist.
- 6. The method of claim 6, wherein the Ca++ antagonist is nifedipine.
- 7. A pharmaceutical composition comprising an MT-3 agonist of the following formula I:
- 8. The pharmaceutical composition of claim 7, further comprising a Ca++ antagonist.
- 9. The pharmaceutical composition of claim 8, wherein the Ca++ antagonist is nifedipine.
- 10. The method of claim 1, further comprising administration of a serotonin reuptake inhibitor.
- 11. The method of claim 1, further comprising the administration of a tricyclic antidepressant.
- 12. The method of claim 11, wherein the tricyclic antidepressant is bupropion.
CROSS-REFERENCE OF RELATED APPLICATION
[0001] This application is a continuation-in-part of U.S. patent application Ser. No. 09/559,609 filed on Apr. 27, 2000, the content of which is relied upon and incorporated by reference in its entirety, and benefit of priority under 35 USC § 120 in hereby claimed, which claims the benefit of U.S. Provisional Application No. 60/134,573 filed May 17, 1999.
Provisional Applications (1)
|
Number |
Date |
Country |
|
60134573 |
May 1999 |
US |
Continuations (1)
|
Number |
Date |
Country |
Parent |
09834041 |
Apr 2001 |
US |
Child |
10390967 |
Mar 2003 |
US |
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
09559609 |
Apr 2000 |
US |
Child |
09834041 |
Apr 2001 |
US |