Claims
- 1. A method for treating hypoxia comprising, administering to a host in need of said treatment a compound or salt thereof represented by formula (1), ##STR13## wherein R.sup.1 is a hydrogen atom, a lower alkyl group, a lower alkenyl group, a lower alkynyl group or a phenyl-lower alkyl group; Z is a group of the formula ##STR14## in which R.sup.2 is a hydrogen atom or a lower alkyl group; and the bond indicated as is a single or double bond, a group of the formula --(CH.sub.2).sub.3 --, a group of the formula --O--CH.sub.2 -- or a group of the formula --S--CH.sub.2 --; R.sup.3 is a pyridyl group, or a phenyl group which may have 1 to 3 substituents selected from the group consisting of a halogen atom, a lower alkyl group, a lower alkoxy group and a hydroxy group; and a group of the formula ##STR15## is a group of the formula ##STR16## and A is a lower alkylene group; provided that when a group of the formula ##STR17## is a group of the formula ##STR18## then Z is a group of the formula ##STR19## and at the same time R.sup.3 should be neither a pyridyl group nor a phenyl group having at least one hydroxy group as the substituent; or when R.sup.3 is a pyridyl group, then Z is a group of the formula ##STR20##
- 2. The method according to claim 1, wherein R.sup.3 in the general formula (1) is a phenyl group which may have 1 to 3 substituents selected from the group consisting of a halogen atom, a C.sub.1 -C.sub.6 alkyl group, a C.sub.1 -C.sub.6 alkoxy group and a hydroxy group.
- 3. The method according to claim 2, wherein R.sup.3 in the general formula (1) is a phenyl group which may have 1 to 2 substituents selected from the group consisting of a halogen atom, a C.sub.1 -C.sub.6 alkyl group, a C.sub.1 -C.sub.6 alkoxy group and a hydroxy group.
- 4. The method according to claim 3, wherein Z in the general formula (1) is a group of the formula ##STR21## (wherein R.sup.2 is a hydrogen atom or a C.sub.1 -C.sub.6 alkyl group; and the bond indicated as is the same defined above).
- 5. The method according to claim 4, wherein R.sup.2 in the general formula (1) is a hydrogen atom.
- 6. The method according to claim 3, wherein Z in the general formula (1) is a group of the formula --O--CH.sub.2 --.
- 7. The method according to claim 3, wherein Z in the general formula (1) is a group of the formula --(CH.sub.2).sub.3 -- or a group of the formula --S--CH.sub.2 --.
- 8. The method according to claims 5, 6 or 7, wherein R.sup.1 in the general formula (1) is a hydrogen atom or a C.sub.1 -C.sub.6 alkyl group.
- 9. The method according to claim 1, wherein R.sup.3 in the general formula (1) is a pyridyl group.
- 10. A method for treating hypoxia which comprises administering to a host in need thereof a 7-{3-[4-(4-Methylphenyl)-1-piperazinyl]propoxy}-3,4-dihydrocarbostyril or a salt thereof in an amount effective for said treatment.
- 11. A method for treating hypoxia which comprises administering to a host in need thereof a 6-{3-[4-(3-(Methylphenyl)-1-piperazinyl]propoxy}-2H-1,4-benzoxazin-3(4H)-one or a salt thereof in an amount effective for said treatment.
- 12. A method for treating hypoxia which comprises administering to a host in need thereof a 7-{3-[4-(3-Chlorophenyl)-1-piperazinyl]propoxy}-3,4-dihydrocarbostyril or a salt thereof in an amount effective for said treatment.
- 13. A method for treating hypoxia which comprises administering to a host in need thereof a 7-{3-[4-(3-Methylphenyl)-1,2,5,6-tetrahydro-1-pyridyl]propoxy}-3,4-dihydrocarbostyril or a salt thereof in an amount effective for said treatment.
- 14. A method for treating hypoxia which comprises administering to a host in need thereof a 6-{3-[4-(2,3-Dimethylphenyl)-1-piperazinyl]propoxy-}-2H-1,4-benzoazine-3(4H)-one or a salt thereof in an amount effective for said treatment.
- 15. A method for treating hypoxia which comprises administering to a host in need thereof a 7-{3-[4-(4-Chlorophenyl)-1-piperazinyl]propoxy}-3,4-dihydrocarbostyril or a salt thereof in an amount effective for said treatment.
Priority Claims (3)
Number |
Date |
Country |
Kind |
60-277632 |
Dec 1985 |
JPX |
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60-277633 |
Dec 1985 |
JPX |
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60-277634 |
Dec 1985 |
JPX |
|
Parent Case Info
This is a continuation of application Ser. No. 938,068, filed Dec. 4, 1986, now abandoned.
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
4154832 |
Silvestrini |
May 1979 |
|
4734416 |
Banno et al. |
Mar 1988 |
|
Foreign Referenced Citations (5)
Number |
Date |
Country |
55-124766 |
Sep 1980 |
JPX |
56-49361 |
May 1981 |
JPX |
57-145872 |
Sep 1982 |
JPX |
57-193461 |
Nov 1982 |
JPX |
59-7067565 |
Apr 1984 |
JPX |
Non-Patent Literature Citations (2)
Entry |
Tucker, Agents and Actions, vol. 10, No. 3, Jun. 1980, pp. 207-212. |
Larsson et al., Acta Paediatrica Scandinavica, vol. 71, No. 3, May 1982, pp. 399-402. |
Continuations (1)
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Number |
Date |
Country |
Parent |
938068 |
Dec 1986 |
|