Claims
- 1. A method for tumor diagnosis which comprises:
(a) administering to a subject suspected of having a tumor, a compound of the formula I, I′ or I″ 5wherein
A represents OH, OR1, —O—(CH2)n—Y, —S—(CH2)n—Y, —NH—(CH2)n—Y, —O—(CH2)2—NH2, —O—(CH2)2—OH, —NH—(CH2)2—NH—BOC or —N—(CH2—CH═CH2)2 wherein R1 represents Na+, K+, (Ca2+)0.5, (Mg2+)0.5, Li+, NH4++NH3—C (CH2OH)3, +NH3—CH2—(CHOH)4—CH2OH, +NH2(CH3)—CH2—(CHOH)4—CH2OH or +N (Cn,H2n,+1)4; R2 represents H, OH or COOR4, wherein R4 is C1-C12 alkyl or C3-C12 cycloalkyl; R3 represents H, OH or C1-C12 alkyl or alkoxy; n is 1, 2, 3, 4, 5 or 6, Y is —NR′1R′2 or —+NR′1R′2R′3, X− wherein R′1, R′2 and R′3 independently from each other represent —CH3 or —C2H5; X is F, Cl, Br or I, n′ is 1, 2, 3 or 4, and wherein ★ denotes an asymmetric carbon and—represents a single saturated bond or a double unsaturated bond; and (b) irradiating the subject by standard procedures and measuring the fluorescence of the suspected area, wherein a higher fluorescence indicates tumor sites.
- 2. A method according to claim 1 which comprises administering a compound I of the formula and optical configuration as indicated below:
- 3. The method according to claim 2 which comprises administering the compound wherein A is OH, herein identified as Pd-Bacteriopheophorbide a (Pd-BPheid).
Priority Claims (1)
Number |
Date |
Country |
Kind |
133253 |
Sep 1999 |
IL |
|
CROSS-REFERENCE TO RELATED APPLICATIONS
[0001] The present application is a divisional application of U.S. application Ser. No. 09/857,772, filed Jun. 11, 2001, which is the national stage under 35 U.S.C. 371 of international application PCT/IL99/00673, filed Dec. 9, 1999 which designated the United States, and which international application was published under PCT Article 21(2) in the English language.
Divisions (1)
|
Number |
Date |
Country |
Parent |
09857772 |
Sep 2001 |
US |
Child |
10414007 |
Apr 2003 |
US |