Claims
- 1. In a therapeutic method of treating a cardiac arrhythmia in an individual in whom such therapy is indicated by administration of an antiarrhytmic agent, the improvement comprising:
- administering to the individual an effective antiarrhythmic amount of a compound having the formula, ##STR15## or a pharmacologically acceptable, non-toxic salt thereof, in which: R.sup.1 is selected from the group consisting of 2-pyridyl, 3-pyridyl, or 4-pyridyl radicals; and
- R.sup.2 is selected from the group consisting of a hydrogen atom or a hydroxyl group.
- 2. The method as in claim 1, wherein the compound is 3-[3-(4-phenyl-1-piperidyl)propyl]-5-phenyl-5-(2-pyridyl)-hydantoin.
- 3. The method as in claim 1, wherein the compound is 3-[3-(4-phenyl-1-piperidyl)propyl]-5-phenyl-5-(2-pyridyl)-hydantoin maleate.
- 4. The method as in claim 1, wherein the compound is 3-[3-(4-hydroxy-4-phenyl-1-piperidyl)propyl]-5-phenyl-5-(2-pyridyl)hydantoin.
- 5. The method as in claim 1, wherein the compound is 3-[3-(4-hydroxy-4-phenyl-1-piperidyl)propyl]-5-phenyl-5-(2-pyridyl)hydantoin maleate.
- 6. The method as in claim 1, wherein the compound is 3-[3-(4-phenyl-1-piperidyl)propyl]-5-phenyl-5-(2-pyridyl)-hydantoin methiodide.
- 7. The method as in claim 1, wherein the compound is 3-[3-(4-phenyl-1-piperidyl)propyl]-5-phenyl-5-(3-pyridyl)-hydantoin.
- 8. The method as in claim 1, wherein the compound is 3-[3-(4-phenyl-1-piperidyl)propyl]-5-phenyl-5-(3-pyridyl)-hydantoin maleate.
- 9. The method as in claim 1, wherein the compound is 3-[3-(4-phenyl-1-piperidyl)propyl]-5-phenyl-5-(4-pyridyl)-hydantoin.
- 10. The method as in claim 1, wherein the compound is 3-[3-(4-phenyl-1-piperidyl)propyl]-5-phenyl5-(4-pyridyl)-hydantoin maleate.
Parent Case Info
This is a division of application Ser. No. 664,920, filed Mar. 8, 1976, now U.S. Pat. No. 3,994,904.
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
2526231 |
Henze |
Oct 1950 |
|
3892748 |
Hayao et al. |
Jul 1975 |
|
Non-Patent Literature Citations (1)
Entry |
Casagrande "Il Farmaco Ed. Sci." vol. 29, pp. 757-785 (1974). |
Divisions (1)
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Number |
Date |
Country |
Parent |
664920 |
Mar 1976 |
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