Claims
- 1. A method of treating leukemia in a subject in need of said treatment, comprising administering to said subject a compound of Formula IA or a physiologically acceptable salt thereof: ##STR11## wherein: R.sub.1 and R.sub.2 are each independently selected from the group consisting of H, lower alkyl, alkoxyalkyl, cycloalkyl, aryl, alkylaryl, hydroxyalkyl, aminoalkyl, or alkylaminoalkyl, or R.sub.1 and R.sub.2 together represent a C.sub.2 to C.sub.10 alkyl, hydroxyalkyl, or alkylene or R.sub.1 and R.sub.2 together are: ##STR12## wherein n is a number from 1 to 3, and R.sub.10 is H or --CONHR.sub.11 NR.sub.15 R.sub.16, wherein R.sub.11 is lower alkyl and R.sub.15 and R.sub.16 are each independently selected from the group consisting of H and lower alkyl; and
- R.sub.3 is H, hydroxy, lower alkyl, cycloalkyl, aryl, alkylaryl, alkoxyalkyl, hydroxycycloalkyl, alkoxycycloalkoxy, hydroxyalkyl, aminoalkyl or alkylaminoalkyl;
- R.sub.4 and R.sub.5 are each independently selected from the group consisting of H, lower alkyl, halogen, aryl, arylalkyl, aminoalkyl, aminoaryl, oxyalkyl, oxyaryl, or oxyarylalkyl; and
- R.sub.12 is hydrogen, lower alkyl, hydroxy, aminoalkyl or alkylaminoalkyl;
- or a physiologically effective salt thereof
- in an amount effective to treat leukemia.
- 2. The method according to claim 1 wherein R.sub.1 and R.sub.2 together represent a C.sub.2 to C.sub.4 alkylene, and R.sub.3 is H.
- 3. The method according to claim 2, wherein R.sub.1 and R.sub.2 together represent ##STR13##
- 4. The method according to claim 2, wherein R.sub.1 and R.sub.2 together represent ##STR14##
- 5. The method according to claim 2, wherein each of R.sub.1, R.sub.2 and R.sub.3 is H.
- 6. The method according to claim 2, wherein each of R.sub.1 and R.sub.3 is H and R.sub.2 is lower alkyl.
- 7. The method according to claim 1, wherein said compound is selected from the group consisting of:
- 2,5-bis(5-amidino-2-benzimidazolyl)pyrrole;
- 2,5-bis-�5-(2-imidazolinyl)-2-benzimidazolyl!pyrrole;
- 1-methyl-2,5-bis(5-amidino-2-benzimidazolyl)pyrrole;
- 1-methyl-2,5-bis�5-(2-imidazolyl)-2-benzimidazolyl!pyrrole; and
- 1-methyl-2,5-bis�5-(1,4,5,6-tetrahydro-2-pyrimidinyl)-2-benzimidazolyl!pyrrole;
- or a physiologically acceptable salt thereof.
Parent Case Info
This application is a divisional of application Ser. No. 08/472,996, filed Jun. 7, 1995, now U.S. Pat. No. 5,643,935.
Government Interests
The present invention was made with Government support under Grant Number 1UO1-AI3363 from the National Institutes of Health. The Government has certain rights to this invention.
Foreign Referenced Citations (1)
Number |
Date |
Country |
9640997 |
Dec 1996 |
WOX |
Divisions (1)
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Number |
Date |
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Parent |
472996 |
Jun 1995 |
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